KR20240058157A - 희토류 원소 및/또는 s-, p-, d- 블록 금속의 착물 형성을 위한 화합물, 이의 배위 화합물, 펩타이드 접합체, 이의 제조 방법 및 그 용도 - Google Patents

희토류 원소 및/또는 s-, p-, d- 블록 금속의 착물 형성을 위한 화합물, 이의 배위 화합물, 펩타이드 접합체, 이의 제조 방법 및 그 용도 Download PDF

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KR20240058157A
KR20240058157A KR1020247011923A KR20247011923A KR20240058157A KR 20240058157 A KR20240058157 A KR 20240058157A KR 1020247011923 A KR1020247011923 A KR 1020247011923A KR 20247011923 A KR20247011923 A KR 20247011923A KR 20240058157 A KR20240058157 A KR 20240058157A
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group
cooh
arom
dcm
evaporated
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Korean (ko)
Inventor
밀로슬라프 폴라세크
토마스 다비드
미칼 스트라카
아담 자로스
Original Assignee
우스타브 오르가니케 케미에 아 비오케미에 아베 쩨에르, 베.베.이
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Publication of KR20240058157A publication Critical patent/KR20240058157A/ko
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    • G—PHYSICS
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
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    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
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    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
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    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
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    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
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    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
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    • C07—ORGANIC CHEMISTRY
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
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    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
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    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
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    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
KR1020247011923A 2021-09-10 2022-09-09 희토류 원소 및/또는 s-, p-, d- 블록 금속의 착물 형성을 위한 화합물, 이의 배위 화합물, 펩타이드 접합체, 이의 제조 방법 및 그 용도 Pending KR20240058157A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP21196175.0A EP4148051A1 (en) 2021-09-10 2021-09-10 Compounds for complexation of rare earth elements and/or s-, p-, d- block metals, their coordination compounds, peptide conjugates, method of their preparation and use thereof
EP21196175.0 2021-09-10
PCT/CZ2022/050087 WO2023036350A1 (en) 2021-09-10 2022-09-09 Compounds for complexation of rare earth elements and/or s-, p-, d- block metals, their coordination compounds, peptide conjugates, method of their preparation and use thereof

Publications (1)

Publication Number Publication Date
KR20240058157A true KR20240058157A (ko) 2024-05-03

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Application Number Title Priority Date Filing Date
KR1020247011923A Pending KR20240058157A (ko) 2021-09-10 2022-09-09 희토류 원소 및/또는 s-, p-, d- 블록 금속의 착물 형성을 위한 화합물, 이의 배위 화합물, 펩타이드 접합체, 이의 제조 방법 및 그 용도

Country Status (9)

Country Link
US (1) US20250147039A1 (https=)
EP (2) EP4148051A1 (https=)
JP (1) JP2024533430A (https=)
KR (1) KR20240058157A (https=)
CN (1) CN118215658A (https=)
AU (1) AU2022343785B9 (https=)
CA (1) CA3229808A1 (https=)
IL (1) IL310752B2 (https=)
WO (1) WO2023036350A1 (https=)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1694895A (en) * 1994-01-28 1995-08-15 Mallinckrodt Medical, Inc. Functionalized aza-bimacrocyclic ligands for imaging applications
KR101199570B1 (ko) * 2009-09-09 2012-11-13 경북대학교 산학협력단 신규한 테트라아자 거대고리 화합물, 제조방법 및 그 용도
EP2604281B1 (en) * 2011-12-14 2014-07-30 Centre National de la Recherche Scientifique (CNRS) Clicked somatostatin conjugated analogs for biological applications
EP3757098A1 (en) * 2019-06-25 2020-12-30 Ustav Organicke Chemie a Biochemie AV CR, v.v.i. Cyclen based compounds, coordination compounds, peptides, pharmaceutical preparation, and use thereof

Also Published As

Publication number Publication date
EP4377308A1 (en) 2024-06-05
EP4148051A1 (en) 2023-03-15
AU2022343785A1 (en) 2024-02-29
IL310752B2 (en) 2024-10-01
JP2024533430A (ja) 2024-09-12
EP4377308C0 (en) 2024-11-20
IL310752B1 (en) 2024-06-01
WO2023036350A1 (en) 2023-03-16
CN118215658A (zh) 2024-06-18
IL310752A (en) 2024-04-01
US20250147039A1 (en) 2025-05-08
CA3229808A1 (en) 2023-03-16
EP4377308B1 (en) 2024-11-20
AU2022343785A9 (en) 2025-03-20
AU2022343785B9 (en) 2025-03-20

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