KR20240055321A - A cosmetic composition comprising Curcuma longa extract and Senna alexandrina extract for blue light interception - Google Patents
A cosmetic composition comprising Curcuma longa extract and Senna alexandrina extract for blue light interception Download PDFInfo
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- KR20240055321A KR20240055321A KR1020220135463A KR20220135463A KR20240055321A KR 20240055321 A KR20240055321 A KR 20240055321A KR 1020220135463 A KR1020220135463 A KR 1020220135463A KR 20220135463 A KR20220135463 A KR 20220135463A KR 20240055321 A KR20240055321 A KR 20240055321A
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- extract
- senna
- blue light
- turmeric
- preventing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P17/16—Emollients or protectives, e.g. against radiation
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- A—HUMAN NECESSITIES
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/318—Foods, ingredients or supplements having a functional effect on health having an effect on skin health and hair or coat
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
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Abstract
본 발명은 강황 추출물과 센나 추출물을 유효성분으로 포함하는 피부 광손상의 예방, 개선 또는 치료용 약학적 조성물, 피부 광손상의 예방 또는 개선용 건강기능식품 조성물, 블루라이트 차단용 화장료 조성물 및 상기 강황 추출물과 센나 추출물의 제조방법에 관한 것이며, 상기 조성물들은 300~420 nm 파장의 블루라이트의 흡수시켜 피부 세포를 보호할 수 있다.The present invention provides a pharmaceutical composition for preventing, improving or treating skin photodamage containing turmeric extract and senna extract as active ingredients, a health functional food composition for preventing or improving skin photodamage, a cosmetic composition for blocking blue light, and the turmeric It relates to extracts and methods for producing senna extracts, and the compositions can protect skin cells by absorbing blue light with a wavelength of 300 to 420 nm.
Description
본 발명은 강황 추출물과 센나 추출물을 유효성분으로 함유하는 피부 광손상의 예방, 개선 또는 치료용 약학적 조성물, 강황 추출물과 센나 추출물을 유효성분으로 함유하는 블루라이트 차단용 화장료 조성물에 관한 것으로, 더욱 상세하게는 강황 추출물과 센나 추출물을 유효성분으로 함유하여 여러 광원으로부터 발산되는 블루라이트에 의한 피부 광손상을 사전에 차단하고 예방, 개선 또는 치료할 수 있는 블루라이트 차단용 조성물에 관한 것이다.The present invention relates to a pharmaceutical composition for preventing, improving or treating skin photodamage containing turmeric extract and senna extract as active ingredients, and a cosmetic composition for blocking blue light containing turmeric extract and senna extract as active ingredients. In detail, it relates to a blue light blocking composition that contains turmeric extract and senna extract as active ingredients and can prevent, improve, or treat skin photodamage caused by blue light emitted from various light sources.
피부는 우리 몸의 가장 큰 기관으로써 외부에 노출되어 있어 외부 자극으로부터 신체를 보호하는 역할을 한다. 여러 외부 자극 중 햇빛에 의한 광손상이 가장 잘 알려져 있다. 그러나 최근에는 TV, 컴퓨터, 스마트폰 등의 전자기기의 디스플레이와 LED 조명기기 등에 의한 블루라이트가 피부에 미치는 유해성에 대한 연구가 이루어지고 있다(Liebmann J., et al., J. Invest. Dermatol. 130(1), 259-269 (2010); Nakashima Y., et al., Free Radic. Bio. Med. 108, 300-310(2017)). 블루라이트란 가시광선 영역에서 푸른색 계열의 빛으로 높은 에너지를 갖는 300~500 nm 파장의 빛이다. 블루라이트는 태양의 자외선보다 더 깊은 피부 층에 침투하기 때문에 활성산소(ROS)를 생성하고, 세포의 미토콘드리아 DNA 손상, 세포 기능장애, 세포 노화를 야기한다고 알려져 있다 (Godley BF. et al., J. Biol. Chem. 280(22), 21061-21066 (2005)).The skin is the largest organ in our body and is exposed to the outside, so it plays a role in protecting the body from external stimuli. Among various external stimuli, photodamage caused by sunlight is the best known. However, recently, research has been conducted on the harmful effects of blue light on the skin caused by displays of electronic devices such as TVs, computers, smartphones, and LED lighting devices (Liebmann J., et al., J. Invest. Dermatol. 130(1), 259-269 (2010); Nakashima Y., Free Radic Bio. 108, 300-310 (2017). Blue light is blue light in the visible light range and has a wavelength of 300 to 500 nm with high energy. Because blue light penetrates deeper skin layers than the sun's ultraviolet rays, it is known to generate reactive oxygen species (ROS) and cause cell mitochondrial DNA damage, cell dysfunction, and cell aging (Godley BF. et al., J Biol. 280(22), 21061-21066 (2005).
세포 내부에 직·간접적으로 생성된 자유 라디칼은 피부 세포의 단백질, 지질 등을 산화시키거나 DNA를 파괴시켜 세포사멸 또는 피부암을 유발하게 한다(Kang, S., et al., Am. J. Pathol., 166, 1691-1699(2005); Matsumura, Y., at al., Toxicol. Appl. Pharmacol., 195(3), 298-308(2004)).Free radicals generated directly or indirectly inside cells oxidize proteins and lipids in skin cells or destroy DNA, causing apoptosis or skin cancer (Kang, S., et al., Am. J. Pathol ., 166, 1691-1699 (2005); Matsumura, Y., Toxicol. Appl., 195(3), 298-308 (2004).
일반적으로, 세포 내 항산화 효소들은 산화적 손상으로부터 보호하기 위하여 서로 상호작용을 형성한다. 산화적 스트레스는 자유 라디칼이 세포 내의 항산화 효소간 상호작용하는 능력을 초과할 때 형성된다. 산화적 스트레스는 염증 및 광손상의 병리과정에서 중요한 역할을 하는 것으로 보고된 바 있다(Simon R. et al., Free Radic. Biol. Med., 49, 1603-1616(2010); Afaq F., et al., Experimentla Dematology, 15, 678-684(2006)). 따라서 블루라이트 파장 흡수력 및 항산화력은 피부세포 손상에 대한 예방효과를 가질 수 있다.Generally, intracellular antioxidant enzymes interact with each other to protect against oxidative damage. Oxidative stress forms when free radicals exceed the ability of antioxidant enzymes within cells to interact. Oxidative stress has been reported to play an important role in the pathological process of inflammation and photodamage (Simon R. et al., Free Radic. Biol. Med., 49, 1603-1616 (2010); Afaq F., et al., Experimental Dematology, 15, 678-684 (2006)). Therefore, blue light wavelength absorption and antioxidant power can have a preventive effect on skin cell damage.
강황(Curcuma longa)은 생강과(Zingiberaceae)에 속하는 다년생식품으로 인도가 원산지이고 식품에 노란색을 부여하는 천연향신료로 알려져 있다. 주요성분은 탄수화물 약 70%와 Curcuminoids로 구성되어 있으며 그 중 폴리페놀 성분인 Curcumin이 약 90%를 차지하고 있다(Anandakumar S et al., J. Korean Soc Food Sci Nutr 43(4), 612-617(2014)).Turmeric ( Curcuma longa ) is a perennial food belonging to the Zingiberaceae family, is native to India, and is known as a natural spice that gives food a yellow color. The main ingredients consist of about 70% carbohydrates and curcuminoids, of which curcumin, a polyphenol component, accounts for about 90% (Anandakumar S et al., J. Korean Soc Food Sci Nutr 43(4), 612-617( 2014)).
센나 (Senna alexandrina Mill)는 콩과(Fabaceae)의 관목으로 아프리카와 인도가 원산지이다. 높이는 1 m까지 자라는 야관목이다. 줄기는 녹색이며 잎은 깃꼴 ?잎으로 둥근 타원형으로 가장자리는 톱니가 없이 밋밋하고, 두꺼운 편이다. 꽃은 3~4월에 황색으로 산방화서로 달린다. 열매는 협과로 초여름에 녹색이나 마르면 갈색이 된다.Senna (Senna alexandrina Mill) is a shrub of the legume family (Fabaceae) and is native to Africa and India. It is a night shrub that grows up to 1 m in height. The stem is green and the leaves are pinnate, round-oval in shape, with smooth, thick edges without serrated edges. Flowers grow in yellow corymbs from March to April. The fruit is green in early summer, but turns brown when it dries.
한국 등록특허공보 제10-1121008호는 식물추출물을 활용한 보습 및 진피 강화 효과가 우수한 화장료 조성물을 개시하고 있고, 대한민국 특허공개 제10-1587443호는 센나 추출물, 티네블린글루코사이드를 함유하는 피부노화 방지 및 주름개선용 화장료 조성물을 개시한 바 있다.Korean Patent Publication No. 10-1121008 discloses a cosmetic composition with excellent moisturizing and dermal strengthening effects using plant extracts, and Korean Patent Publication No. 10-1587443 discloses an anti-skin aging product containing senna extract and tineblin glucoside. and a cosmetic composition for improving wrinkles.
한국 공개특허공보 제10-2018-0137151호는 강황 잎 및 황촉규의 혼합추출물을 유효성분으로 포함하는 광노화 억제용 화장료 조성물을 개시하고 있고, 한국 등록특허공보 제10-143587호는 강황 잎 추출물을 함유하는 화장료 조성물 및 그 제조방법을 개시하고, 한국 공개특허공보 제10-2016-0094690호에서는 강황을 자외선 차단제로 적용한 기술이 제안되어 있다.Korean Patent Publication No. 10-2018-0137151 discloses a cosmetic composition for suppressing photoaging containing mixed extracts of turmeric leaves and Hwang Sok-gyu as active ingredients, and Korean Patent Publication No. 10-143587 contains turmeric leaf extract. A cosmetic composition and a method for manufacturing the same are disclosed, and Korean Patent Publication No. 10-2016-0094690 proposes a technology for applying turmeric as a sunscreen.
그러나 지금까지 알려진 강황 추출물과 센나 추출물 복합을 이용한 블루라이트 차단용 화장료 조성물에 대해서는 알려진 바가 없다. 따라서 발명자들은 강황 추출물과 센나 추출물 복합이 300~420 nm의 블루라이트파장 흡광도를 통하여 블루라이트 차단 효과를 확인하였다.However, there is no known cosmetic composition for blocking blue light using a combination of turmeric extract and senna extract. Therefore, the inventors confirmed the blue light blocking effect of the turmeric extract and senna extract combination through the blue light wavelength absorbance of 300 to 420 nm.
따라서, 상기와 같은 문제점을 해결하기 위해 본 발명은 강황 추출물과 센나 추출물을 이용하여 피부 광손상의 예방, 개선 또는 치료용 약학적 조성물 또는 블루라이트 차단용 화장료 조성물을 제공하고자 한다.Therefore, in order to solve the above problems, the present invention seeks to provide a pharmaceutical composition for preventing, improving, or treating skin photodamage or a cosmetic composition for blocking blue light using turmeric extract and senna extract.
상기 목적을 달성하기 위해 본 발명은 강황 추출물과 센나 추출물을 유효성분으로 블루라이트 차단용 화장료 조성물을 제공한다.To achieve the above object, the present invention provides a cosmetic composition for blocking blue light using turmeric extract and senna extract as active ingredients.
또한, 상기 강황 추출물과 센나 추출물의 제조방법을 제공한다. Additionally, a method for producing the turmeric extract and senna extract is provided.
본 발명에서의 블루라이트(Blue light)는 300~500㎚의 짧은 파장을 내는 가시광선의 한 종류로, 컴퓨터 모니터·스마트폰·TV 등에서 나오는 파란색 계열의 광원을 의미한다.Blue light in the present invention is a type of visible light that emits a short wavelength of 300 to 500 nm, and refers to a blue light source emitted from computer monitors, smartphones, TVs, etc.
본 발명에서의 피부 광손상은 일광 노출로 인해 피부가 손상된 것을 의미하며, 상기 광손상은 자외선, 적외선, 블루라이트 등을 포함하는 가시광선, UV 등에 의한 손상일 수 있으나, 바람직하게는 블루라이트에 의한 손상일 수 있다. In the present invention, skin photodamage means damage to the skin due to exposure to sunlight. The photodamage may be damage caused by visible light, UV, etc., including ultraviolet rays, infrared, blue light, etc., but is preferably caused by blue light. It could be damage.
상기 피부 광손상은 피부의 비박화(thinning of the skin), 피부 위축증(skin atrophy), 콜라겐 섬유(collagen fiber)와 탄성 섬유(elastic fiber)의 감소, 탄력섬유증(elastosis), 피부 탄력성의 손실(loss of skin elasticity), 건조(dryness), 주름 형성(wrinkle formation), 염증세포 침윤(inflammatory cells infiltration), 조기 피부 노화(premature skin aging), 혈관 변화(vascular change), 색소 변화(pigmentary change), 면포(comedone), 낭종(cyst) 및 피부 병리적 변화(skin pathologic change)를 포함하나, 이에 제한되는 것은 아니다.The skin photodamage includes thinning of the skin, skin atrophy, reduction of collagen fibers and elastic fibers, elastosis, and loss of skin elasticity ( loss of skin elasticity, dryness, wrinkle formation, inflammatory cell infiltration, premature skin aging, vascular change, pigmentary change, Includes, but is not limited to, comedones, cysts, and skin pathologic changes.
본 발명의 바람직한 구현예에 따르면, 강황과 센나 추출물은 극성 용매, 예컨대 물이나 탄소수 1 내지 4의 저급알코올 또는 알코올 수용액을 이용하여 추출하는 제조방법에 의해 제조된 것을 바람직하게 사용할 수 있다. 더욱 바람직하게는 탄소수 1-4의 저급알코올 추출물을 사용할 수 있다.According to a preferred embodiment of the present invention, turmeric and senna extracts can be preferably used by extraction using a polar solvent, such as water, a lower alcohol having 1 to 4 carbon atoms, or an aqueous alcohol solution. More preferably, a lower alcohol extract having 1-4 carbon atoms can be used.
강황 추출물과 센나 추출물의 블루라이트 차단 효과 또는 피부 광손상의 예방, 개선, 또는 치료 효과를 증대시키는 상기 제조방법은 강황과 센나를 에탄올 수용액, 메탄올 수용액, 이소프로판올 수용액, 부탄올수 용액 등의 탄소수 1 내지 4의 알코올 또는 알코올 수용액을 이용하여 추출하는 단계이다.The manufacturing method for increasing the blue light blocking effect of turmeric extract and senna extract or the prevention, improvement, or treatment effect of skin photodamage is to mix turmeric and senna with 1 to 1 carbon atoms such as ethanol aqueous solution, methanol aqueous solution, isopropanol aqueous solution, or butanol aqueous solution. This is the extraction step using alcohol or alcohol aqueous solution in step 4.
또한 상기 알코올 수용액의 알코올 함량은 약 50 중량% 내지 약 100 중량%가 바람직하며, 약 75 중량% 내지 약 95 중량%가 더욱 바람직하다.Additionally, the alcohol content of the alcohol aqueous solution is preferably about 50% by weight to about 100% by weight, and more preferably about 75% by weight to about 95% by weight.
상기 추출 단계에서, 추출은 40-80℃에서 수행되는 것이 바람직하고, 온도가 너무 낮을 경우 추출 수율이 떨어지고, 추출 시간이 길어지며, 너무 높은 온도에서 추출할 경우 유효 성분들의 변성이 있을 수 있다.In the extraction step, the extraction is preferably performed at 40-80°C. If the temperature is too low, the extraction yield decreases, the extraction time becomes long, and if the temperature is too high, the active ingredients may be denatured.
본 발명에 따른 강황 추출물과 센나 추출물을 함유하는 약학적 조성물은 상기 강황 추출물, 센나 추출물을 각각 또는 혼합하여 포함하는 경우, 약학조성물 전체 중량의 0.1 내지 99 중량%, 바람직하게는 0.1 내지 5 중량%로 포함할 수 있다. 상기 범위 미만이면, 피부 광손상의 예방, 개선, 또는 치료 효과가 미미하고, 상기 범위를 초과하면 독성이 유발될 수 있다.When the pharmaceutical composition containing the turmeric extract and the senna extract according to the present invention contains the turmeric extract and the senna extract individually or in combination, the amount is 0.1 to 99% by weight, preferably 0.1 to 5% by weight, of the total weight of the pharmaceutical composition. It can be included as . If it is less than the above range, the effect of preventing, improving, or treating skin photodamage is minimal, and if it exceeds the above range, toxicity may occur.
또한, 상기 강황 추출물과 센나 추출물을 혼합하여 포함할 경우, 강황 추출물 : 센나 추출물은 1:1, 바람직하게는 1:1~3의 비율로 포함될 수 있다. 상기 비율을 벗어나는 경우, 효과가 낮아질 수 있다. 상기 범위를 벗어나면 효과가 낮아질 수 있다.In addition, when the turmeric extract and senna extract are mixed, the turmeric extract and senna extract may be included in a ratio of 1:1, preferably 1:1 to 3. If it deviates from the above ratio, the effectiveness may be lowered. If it is outside the above range, the effectiveness may be reduced.
본 발명의 약학적 조성물은 경구 또는 비경구 투여할 수 있으며, 비경구 투여인 경우에는 정맥내 주입, 피하 주입, 근육 주입, 복강 주입, 경피 투여, 점막 투여 및 점안 투여, 국소투여 등의 방식으로 투여할 수 있으나, 이에 제한되는 것은 아니다.The pharmaceutical composition of the present invention can be administered orally or parenterally, and in case of parenteral administration, it can be administered through methods such as intravenous injection, subcutaneous injection, intramuscular injection, intraperitoneal injection, transdermal administration, mucosal administration, eye drop administration, and local administration. It can be administered, but is not limited to this.
본 발명의 약학적 조성물의 적합한 투여량은 제제화 방법, 투여 방식, 환자의 연령, 체중, 성, 병적 상태, 섭취 음식, 투여 시간, 투여 경로, 배설 속도 및 반응 감응성과 같은 요인들에 의해 다양하게 처방될 수 있다. 본 발명의 약학적 조성물의 투여량은 성인 기준으로 0.0001-100 ㎎/kg(체중)일 수 있으나 이에 제한되는 것은 아니다.The appropriate dosage of the pharmaceutical composition of the present invention varies depending on factors such as formulation method, administration method, patient's age, weight, sex, pathological condition, ingested food, administration time, administration route, excretion rate, and reaction sensitivity. may be prescribed. The dosage of the pharmaceutical composition of the present invention may be 0.0001-100 mg/kg (body weight) for adults, but is not limited thereto.
상기 약학적 조성물은 당 업계에서 제조에 통상적으로 사용되는 적절한 담체, 부형제 및 희석제를 더 포함할 수 있다. The pharmaceutical composition may further include appropriate carriers, excipients, and diluents commonly used in manufacturing in the art.
본 발명의 일 실시예에 따른 약학적 조성물에 포함될 수 있는 약학적으로 허용 가능한 담체, 부형제 및 희석제는 락토오스, 덱스트로오스, 수크로오스, 칼슘 실리케이트, 셀룰로오스, 메틸셀룰로오스, 미정질 셀룰로오스, 폴리비닐피롤리돈, 물, 메틸히드록시벤조에이트, 프로필히드록시벤조에이트, 활석, 마그네슘 스테아레이트 및 광물유를 포함하나, 이에 한정되지 않는다.Pharmaceutically acceptable carriers, excipients, and diluents that may be included in the pharmaceutical composition according to an embodiment of the present invention include lactose, dextrose, sucrose, calcium silicate, cellulose, methylcellulose, microcrystalline cellulose, and polyvinylpyrroli. Including, but not limited to, money, water, methyl hydroxybenzoate, propyl hydroxybenzoate, talc, magnesium stearate, and mineral oil.
본 발명에 따른 약학적 조성물은 본 발명이 속하는 기술분야에서 공지된 통상의 방법에 따라 겔, 정제, 캡슐,과립제, 현탁액, 시럽 등의 다양한 제형으로 제형화되어 사용될 수 있다.The pharmaceutical composition according to the present invention can be formulated and used in various dosage forms such as gels, tablets, capsules, granules, suspensions, syrups, etc. according to conventional methods known in the technical field to which the present invention pertains.
본 발명에 따른 강황 추출물과 센나 추출물을 함유하는 화장료 조성물은 상기 강황 추출물, 센나 추출물을 각각 또는 혼합하여 포함하는 경우, 화장료 조성물 전체 중량의 0.1 내지 99 중량%, 바람직하게는 0.1 내지 5중량%로 포함할 수 있다. 상기 범위 미만이면, 피부 광손상의 예방, 개선, 또는 치료 효과가 미미하고, 상기 범위를 초과하면 독성이 유발될 수 있다.When the cosmetic composition containing the turmeric extract and the senna extract according to the present invention contains the turmeric extract and the senna extract individually or in combination, the amount is 0.1 to 99% by weight, preferably 0.1 to 5% by weight, of the total weight of the cosmetic composition. It can be included. If it is less than the above range, the effect of preventing, improving, or treating skin photodamage is minimal, and if it exceeds the above range, toxicity may occur.
또한, 상기 화장료 조성물은 화장료 제조시 통상적으로 사용되는 포함되는 항산화제, 안정화제, 용해화제, 비타민, 안료 및 향료와 같은 통상적인 보조제, 그리고 담체를 추가적으로 포함할 수 있다. 또한, 화장수류, 에센스류, 크림류, 팩류, 파운데이션류, 메이크업베이스류 등과 같은 기초제품, 색조제품 및 두발제품의 다양한 제형으로 제조될 수 있다. 구체적으로 액상, 크림상, 페이스트상 및 고체상 등 다양한 성상으로 적용이 가능하며, 통상적인 화장료 제조법에 의해 제조될 수 있다.In addition, the cosmetic composition may additionally include conventional auxiliaries such as antioxidants, stabilizers, solubilizers, vitamins, pigments and fragrances, and carriers commonly used in the manufacture of cosmetics. In addition, it can be manufactured into various formulations such as basic products such as cosmetics, essences, creams, packs, foundations, makeup bases, etc., color products, and hair products. Specifically, it can be applied in various forms such as liquid, cream, paste, and solid, and can be manufactured by a conventional cosmetic manufacturing method.
본 발명에 따른 강황 추출물과 센나 추출물을 함유하는 식품 조성물은 상기 강황 추출물, 센나 추출물을 각각 또는 혼합하여 포함하는 경우, 식품조성물 전체 중량의 0.1 내지 99 중량%, 바람직하게는 0.1내지 5중량%로 포함할 수 있다. 상기 범위 미만이면, 피부 광손상의 예방, 개선, 또는 치료 효과가 미미하고, 상기 범위를 초과하면 독성이 유발될 수 있다.When the food composition containing the turmeric extract and the senna extract according to the present invention contains the turmeric extract and the senna extract individually or in combination, the amount is 0.1 to 99% by weight, preferably 0.1 to 5% by weight, of the total weight of the food composition. It can be included. If it is less than the above range, the effect of preventing, improving, or treating skin photodamage is minimal, and if it exceeds the above range, toxicity may occur.
본 발명의 강황 추출물과 센나 추출물을 함유하는 식품 조성물은 음료, 껌, 차, 비타민 복합제, 분말, 과립, 정제, 캡슐, 과자 등의 다양한 형태로 제조될 수 있다. 또한 상기 식품 조성물은 본 발명이 속하는 기술분야에서 통상적으로 사용되는 증점제, 안정화제, 향료, pH 조절제, 색소와 같은 첨가제를 추가적으로 더 포함할 수 있다.The food composition containing the turmeric extract and senna extract of the present invention can be manufactured in various forms such as beverages, gum, tea, vitamin complex, powder, granules, tablets, capsules, and confectionery. In addition, the food composition may further include additives commonly used in the technical field to which the present invention pertains, such as thickeners, stabilizers, flavorings, pH adjusters, and colorants.
본 발명에 따른 강황 추출물과 센나 추출물로 이루어진 블루라이트 차단용 화장료 조성물은 블루라이트를 흡수하여 차단하는 효과를 가진다. 따라서, 본 발명의 강황 추출물과 센나 추출물 복합은 블루라이트에 의한 피부의 광손상 치료 및 예방용 약학적 조성물과 광손상 회복 및 예방용 화장료 조성물의 원료로 유용하게 사용될 수 있을 것이다. The cosmetic composition for blocking blue light consisting of turmeric extract and senna extract according to the present invention has the effect of absorbing and blocking blue light. Therefore, the combination of turmeric extract and senna extract of the present invention can be usefully used as a raw material for a pharmaceutical composition for treating and preventing photodamage to the skin caused by blue light and a cosmetic composition for recovering and preventing photodamage.
도 1은 본 발명의 실시예에 따른 추출물이 블루라이트 범위인 300~420nm의 파장에서의 흡광도를 보여준다.
도 2는 본 발명의 실시예에 따른 추출물이 블루라이트 범위인 300~420nm의 파장에서의 흡광도를 Area Under Curve (AUC)로 환산한 수치를 나타낸다.Figure 1 shows the absorbance of an extract according to an example of the present invention at a wavelength of 300 to 420 nm, which is the blue light range.
Figure 2 shows the absorbance of the extract according to an example of the present invention at a wavelength of 300 to 420 nm, which is the blue light range, converted to Area Under Curve (AUC).
이하, 본 발명을 구체적으로 설명하기 위해 실시예, 실험예 등의 구체적인 예를 들어 설명하기로 한다. 그러나, 본 발명에 따른 실시예 또는 실험예들은 여러 가지 다른 형태로 변형될 수 있으며, 본 발명의 범위가 아래에서 상술하는 예들에 한정되는 것으로 해석되어지지 않아야 한다. 본 발명에 따른 실시예 및 실험예들은 당 업계에서 평균적인 지식을 가진 자에게 본 발명을 보다 완전하게 설명하기 위해서 제공 되어지는 것에 불과하므로, 본 출원 시점에 있어서 이들을 대체할 수 있는 다양한 균등물과 변형예들이 있을 수 있음을 이해하여야 한다.Hereinafter, in order to explain the present invention in detail, specific examples such as examples and experimental examples will be described. However, the embodiments or experimental examples according to the present invention may be modified into various other forms, and the scope of the present invention should not be construed as being limited to the examples detailed below. Since the embodiments and experimental examples according to the present invention are merely provided to more completely explain the present invention to those with average knowledge in the art, various equivalents and experimental examples that can replace them at the time of filing the present application are provided. It should be understood that variations may exist.
실시예 1. 추출물의 제조Example 1. Preparation of extract
건조된 강황 50 g, 센나 50 g을 분쇄한 후, 95% 에탄올 500 ml을 가하여 40~80℃에서 2시간 동안 가열추출하고 여과하였다. 이 추출과정을 2회 반복하고 농축하여 각각의 추출물을 얻었다. 상기 추출물들을 DMSO (dimethyl sulfoxide)에 100 mg/ml로 용해시켜 스톡 용액을 제조하여 이용하였다.After pulverizing 50 g of dried turmeric and 50 g of senna, 500 ml of 95% ethanol was added, heat-extracted at 40-80°C for 2 hours, and filtered. This extraction process was repeated twice and concentrated to obtain each extract. The extracts were dissolved in DMSO (dimethyl sulfoxide) at 100 mg/ml to prepare a stock solution.
두 추출물을 1:1 비율로 섞어, 복합추출물을 제조하였다.The two extracts were mixed in a 1:1 ratio to prepare a composite extract.
실험예 1. 각 추출물과 혼합물의 블루라이트 흡수도 평가Experimental Example 1. Evaluation of blue light absorption of each extract and mixture
추출물의 블루라이트 흡광 및 투과 변화를 알아보기 위해 블루라이트 파장인 300nm~420nm에서 측정하였고, 그 결과는 도 1, 도 2에 나타내었다.To determine changes in blue light absorption and transmission of the extract, measurements were made at blue light wavelengths of 300 nm to 420 nm, and the results are shown in Figures 1 and 2.
측정결과, 본 발명의 실시예에 따른 추출물이 블루라이트 범위인 300~420nm의 파장을 흡수하는 것을 보여준다. 강황 추출물과 센나 추출물, 그리고 강황과 센나의 복합물 중 강황과 센나의 복합물이 300~420nm에서 가장 큰 흡광도를 나타내었다(도 1).The measurement results show that the extract according to the embodiment of the present invention absorbs a wavelength of 300 to 420 nm, which is the blue light range. Among the turmeric extract, senna extract, and complex of turmeric and senna, the complex of turmeric and senna showed the highest absorbance at 300-420 nm (Figure 1).
도 1의 결과를 보다 객관적으로 확인하기 위하여, 각 추출물의 300~420nm 흡광도를 Area Under Curve (AUC)로 나타내었다.In order to more objectively confirm the results in Figure 1, the absorbance of each extract from 300 to 420 nm was expressed as Area Under Curve (AUC).
도 2에 따르면, 복합 추출물의 AUC 수치가 가장 높으며, 그 뒤로 강황 추출물, 센나 추출물 순으로 나타났다.According to Figure 2, the AUC value of the composite extract was the highest, followed by turmeric extract and senna extract.
도 1 및 도 2에 따르면, 강황과 센나의 복합 추출물이 각 단일 추출물보다 블루라이트 영역인 300~420nm에서 더 큰 흡광도를 갖는다는 것을 알 수 있다.According to Figures 1 and 2, it can be seen that the complex extract of turmeric and senna has greater absorbance in the blue light range of 300-420 nm than each single extract.
이상 설명한 바와 같이 본 발명은 강황 추출물과 센나 추출물을 유효성분으로 함유한 블루라이트 차단 효과가 뛰어난 천연소재 조성물을 제공하기 때문에, 생명바이오 식품, 화장품, 의약 산업상 매우 유용한 발명인 것이다.As described above, the present invention is a very useful invention in the bio-food, cosmetics, and pharmaceutical industries because it provides a natural material composition with excellent blue light blocking effect containing turmeric extract and senna extract as active ingredients.
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