KR20240051272A - Kras 발현을 조절하기 위한 조성물 및 방법 - Google Patents

Kras 발현을 조절하기 위한 조성물 및 방법 Download PDF

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Publication number
KR20240051272A
KR20240051272A KR1020247011068A KR20247011068A KR20240051272A KR 20240051272 A KR20240051272 A KR 20240051272A KR 1020247011068 A KR1020247011068 A KR 1020247011068A KR 20247011068 A KR20247011068 A KR 20247011068A KR 20240051272 A KR20240051272 A KR 20240051272A
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seq
nucleic acid
composition
oligonucleotide
antisense oligonucleotide
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Korean (ko)
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리샨 첸
보핸 진
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몰레큘라 악시옴, 엘엘씨
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N2310/323—Chemical structure of the sugar modified ring structure
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    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/34—Allele or polymorphism specific uses

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  • Chemical & Material Sciences (AREA)
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  • Genetics & Genomics (AREA)
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  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
KR1020247011068A 2021-09-02 2022-09-01 Kras 발현을 조절하기 위한 조성물 및 방법 Pending KR20240051272A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202163240226P 2021-09-02 2021-09-02
US63/240,226 2021-09-02
US202263315669P 2022-03-02 2022-03-02
US63/315,669 2022-03-02
PCT/US2022/042393 WO2023034537A1 (en) 2021-09-02 2022-09-01 Compositions and methods for modulating kras expression

Publications (1)

Publication Number Publication Date
KR20240051272A true KR20240051272A (ko) 2024-04-19

Family

ID=85411569

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020247011068A Pending KR20240051272A (ko) 2021-09-02 2022-09-01 Kras 발현을 조절하기 위한 조성물 및 방법

Country Status (5)

Country Link
US (1) US20240392293A1 (https=)
EP (1) EP4395901A4 (https=)
JP (1) JP2024532477A (https=)
KR (1) KR20240051272A (https=)
WO (1) WO2023034537A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119855910A (zh) 2022-07-06 2025-04-18 美国微哲默理有限责任公司 用于治疗胰腺癌的组合物和方法
EP4652279A2 (en) * 2023-01-18 2025-11-26 Molecular Axiom, LLC Compositions for modulating kras expression and uses thereof
CN119639745B (zh) * 2024-12-12 2025-11-25 制能(北京)生物科技有限公司 一种靶向kras基因的反义核酸及其药物制剂和应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5877309A (en) * 1997-08-13 1999-03-02 Isis Pharmaceuticals, Inc. Antisense oligonucleotides against JNK
JP2010538678A (ja) * 2007-09-18 2010-12-16 イントラドイグム コーポレーション Ｋ−ｒａｓｓｉＲＮＡ含有組成物及びそれらの使用法
WO2010115202A2 (en) * 2009-04-03 2010-10-07 Dicerna Pharmaceuticals, Inc. Methods and compositions for the specific inhibition of kras by blunt ended double-stranded rna
EA201492004A1 (ru) * 2012-05-02 2015-08-31 Новартис Аг Органические композиции для лечения kras-ассоциированных заболеваний
CN108513588A (zh) * 2015-09-24 2018-09-07 Ionis制药公司 Kras表达的调节剂
US11180759B2 (en) * 2016-01-19 2021-11-23 The University Of North Carolina At Chapel Hill Methods and compositions using RNA interference and antisense oligonucleotides for inhibition of KRAS
KR101997116B1 (ko) * 2016-10-14 2019-07-05 연세대학교 산학협력단 Kras 유전자에 상보적인 가이드 rna 및 이의 용도
WO2018146316A1 (en) * 2017-02-13 2018-08-16 Astrazeneca Ab Combination of a mapk pathway inhibitor and an antisense compound targeted to kras
US11512315B2 (en) * 2018-02-12 2022-11-29 Codiak Biosciences, Inc. Methods and compositions for macrophage polarization
CA3147701A1 (en) * 2019-08-14 2021-02-18 Codiak Biosciences, Inc. Extracellular vesicles with antisense oligonucleotides targeting kras
JP7427227B2 (ja) * 2020-01-21 2024-02-05 学校法人産業医科大学 腫瘍細胞の生存を低下させるｋｒａｓアンチセンスオリゴヌクレオチド及びその用途

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JP2024532477A (ja) 2024-09-05
US20240392293A1 (en) 2024-11-28
EP4395901A1 (en) 2024-07-10
EP4395901A4 (en) 2025-10-01
WO2023034537A1 (en) 2023-03-09

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