KR20240044409A - Wee1 키나아제 저해제로서 유용한 피리도피리미딘 유도체 - Google Patents

Wee1 키나아제 저해제로서 유용한 피리도피리미딘 유도체 Download PDF

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Publication number
KR20240044409A
KR20240044409A KR1020247000364A KR20247000364A KR20240044409A KR 20240044409 A KR20240044409 A KR 20240044409A KR 1020247000364 A KR1020247000364 A KR 1020247000364A KR 20247000364 A KR20247000364 A KR 20247000364A KR 20240044409 A KR20240044409 A KR 20240044409A
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KR
South Korea
Prior art keywords
cancer
tumor
compound
lymphoma
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
KR1020247000364A
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English (en)
Korean (ko)
Inventor
오렌 길라드
조셉 바카
Original Assignee
아프레아 테라퓨틱스, 인크.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 아프레아 테라퓨틱스, 인크. filed Critical 아프레아 테라퓨틱스, 인크.
Publication of KR20240044409A publication Critical patent/KR20240044409A/ko
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020247000364A 2021-06-04 2022-06-03 Wee1 키나아제 저해제로서 유용한 피리도피리미딘 유도체 Pending KR20240044409A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163196744P 2021-06-04 2021-06-04
US63/196,744 2021-06-04
PCT/US2022/032203 WO2022256680A1 (en) 2021-06-04 2022-06-03 Pyridopyrimidine derivatives useful as wee1 kinase inhibitors

Publications (1)

Publication Number Publication Date
KR20240044409A true KR20240044409A (ko) 2024-04-04

Family

ID=82321319

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020247000364A Pending KR20240044409A (ko) 2021-06-04 2022-06-03 Wee1 키나아제 저해제로서 유용한 피리도피리미딘 유도체

Country Status (10)

Country Link
US (1) US20240254123A1 (enExample)
EP (1) EP4347592A1 (enExample)
JP (1) JP2024522304A (enExample)
KR (1) KR20240044409A (enExample)
CN (1) CN117794932A (enExample)
AU (2) AU2022287033B2 (enExample)
CA (1) CA3225152A1 (enExample)
IL (1) IL309037A (enExample)
MX (1) MX2023014466A (enExample)
WO (1) WO2022256680A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3253688A1 (en) 2022-03-07 2023-09-14 Debiopharm International S.A. TREATMENT METHODS FOR SMALL CELL LUNG CANCER
WO2025056747A1 (en) 2023-09-14 2025-03-20 Debiopharm International S.A. Combination of a wee1 inhibitor and a pkmyt1 inhibitor
CN120189510A (zh) * 2023-12-21 2025-06-24 北京哲源科技有限责任公司 一种并环化合物的应用
TW202541810A (zh) 2023-12-22 2025-11-01 瑞士商德彪製藥國際公司 治療實體腫瘤之方法
WO2025186213A1 (en) 2024-03-04 2025-09-12 Debiopharm International S.A. Combination of a wee1 inhibitor and a topoisomerase 1 inhibitor

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002250236A1 (en) 2001-03-02 2002-09-19 Medimmune, Inc. Cd2 antagonists for treatment of autoimmune or inflammatory disease
PE20080695A1 (es) * 2006-04-27 2008-06-28 Banyu Pharma Co Ltd Derivados de dihidropirazolopirimidinona como inhibidores de quinasa weel
MX2014010176A (es) * 2012-02-23 2014-11-10 Abbvie Inc Inhibidores de cinasas de piridopirimidinona.
GB201306610D0 (en) * 2013-04-11 2013-05-29 Almac Discovery Ltd Pharmaceutical compounds
GB201612095D0 (en) * 2016-07-12 2016-08-24 Almac Discovery Ltd Pharmaceutical compounds
MX2020001235A (es) * 2017-08-01 2020-07-20 Recurium Ip Holdings Llc Análogos de 1,2-dihidro-3h-pirazolo[3,4-d]pirimidin-3-ona.
GB201800378D0 (en) * 2018-01-10 2018-02-21 Almac Discovery Ltd Pharmaceutical compounds

Also Published As

Publication number Publication date
MX2023014466A (es) 2024-05-02
US20240254123A1 (en) 2024-08-01
EP4347592A1 (en) 2024-04-10
JP2024522304A (ja) 2024-06-13
IL309037A (en) 2024-02-01
AU2022287033A1 (en) 2024-01-18
AU2022287033B2 (en) 2025-04-17
CN117794932A (zh) 2024-03-29
WO2022256680A1 (en) 2022-12-08
CA3225152A1 (en) 2022-12-08
AU2025204724A1 (en) 2025-07-10

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