KR20240041964A - 입양 면역요법을 위해 기능을 향상시킨 cd3-발현 자연 킬러 세포 - Google Patents

입양 면역요법을 위해 기능을 향상시킨 cd3-발현 자연 킬러 세포 Download PDF

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KR20240041964A
KR20240041964A KR1020247006166A KR20247006166A KR20240041964A KR 20240041964 A KR20240041964 A KR 20240041964A KR 1020247006166 A KR1020247006166 A KR 1020247006166A KR 20247006166 A KR20247006166 A KR 20247006166A KR 20240041964 A KR20240041964 A KR 20240041964A
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seq
composition
cells
tcr
chain
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엔리 류
케이티 레즈바니
라페트 바사르
빈 류
코스타 데이비드 마린
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더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템
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    • A—HUMAN NECESSITIES
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • A61K40/00—Cellular immunotherapy
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    • A61K40/00—Cellular immunotherapy
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    • A61K40/35—Cytokines
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • C12N5/0602—Vertebrate cells
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    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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KR1020247006166A 2021-07-23 2022-07-22 입양 면역요법을 위해 기능을 향상시킨 cd3-발현 자연 킬러 세포 Pending KR20240041964A (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US202163225281P 2021-07-23 2021-07-23
US63/225,281 2021-07-23
US202263310526P 2022-02-15 2022-02-15
US63/310,526 2022-02-15
US202263344931P 2022-05-23 2022-05-23
US63/344,931 2022-05-23
PCT/US2022/074062 WO2023004425A2 (en) 2021-07-23 2022-07-22 Cd3-expressing natural killer cells with enhanced function for adoptive immunotherapy

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KR20240041964A true KR20240041964A (ko) 2024-04-01

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KR1020247006166A Pending KR20240041964A (ko) 2021-07-23 2022-07-22 입양 면역요법을 위해 기능을 향상시킨 cd3-발현 자연 킬러 세포

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Country Link
US (1) US20240325443A1 (https=)
EP (1) EP4373501A4 (https=)
JP (1) JP2024527879A (https=)
KR (1) KR20240041964A (https=)
AU (1) AU2022315301A1 (https=)
CA (1) CA3227317A1 (https=)
IL (1) IL310307A (https=)
MX (1) MX2024001073A (https=)
WO (1) WO2023004425A2 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2020232691B2 (en) 2019-03-05 2023-06-29 Nkarta, Inc. CD19-directed chimeric antigen receptors and uses thereof in immunotherapy
AU2024244976A1 (en) * 2023-03-24 2025-09-25 Board Of Regents, The University Of Texas System Engineered natural killer cells with enhanced antitumor memory responses
AU2024269870A1 (en) * 2023-05-05 2025-11-20 Board Of Regents, The University Of Texas System Multi-receptor natural killer cells
KR20260024372A (ko) * 2023-05-05 2026-02-20 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 다중-수용체 자연 살해 세포
WO2026077446A1 (en) * 2024-10-12 2026-04-16 Nanjing Legend Biotech Co., Ltd. Engineered il-15 constructs and uses thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2854233C (en) * 2011-11-04 2020-05-12 Zymeworks Inc. Stable heterodimeric antibody design with mutations in the fc domain
WO2016054520A2 (en) * 2014-10-03 2016-04-07 The California Institute For Biomedical Research Engineered cell surface proteins and uses thereof
EP3331913A1 (en) * 2015-08-07 2018-06-13 Novartis AG Treatment of cancer using chimeric cd3 receptor proteins
WO2017192536A1 (en) * 2016-05-02 2017-11-09 University Of Kansas Eliminating mhc restriction from the t cell receptor as a strategy for immunotherapy
US11752172B2 (en) * 2017-01-04 2023-09-12 Nova Southeastern University Natural killer (NK) cells expressing an antigen-specific functional T cell receptor (TCR) complex, methods for production thereof, and methods for therapeutic use thereof
WO2019071009A2 (en) * 2017-10-05 2019-04-11 Nantcell, Inc. LIPID ANTIGENS AND L-CELL RECEPTORS ON NK CELLS
CN109777778B (zh) * 2017-11-14 2023-07-18 中国科学院广州生物医药与健康研究院 一种基因改造的γδT细胞
WO2020205359A1 (en) * 2019-03-29 2020-10-08 Board Of Regents, The University Of Texas System Methods for production of car-nk cells and use thereof
EP3750547A1 (en) * 2019-06-13 2020-12-16 Universitätsmedizin der Johannes Gutenberg-Universität Mainz Modified nk-92 cells, and therapeutic and diagnostic uses thereof
EP4003374A4 (en) * 2019-07-23 2023-08-30 Wen Yang COMPOSITION AND METHODS OF ADOPTIVE IMMUNOTHERAPY

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MX2024001073A (es) 2024-05-15
AU2022315301A1 (en) 2024-02-29
WO2023004425A2 (en) 2023-01-26
WO2023004425A3 (en) 2023-03-02
US20240325443A1 (en) 2024-10-03
JP2024527879A (ja) 2024-07-26
EP4373501A4 (en) 2025-06-04
EP4373501A2 (en) 2024-05-29
CA3227317A1 (en) 2023-01-26
IL310307A (en) 2024-03-01

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