KR20240035502A - 신독성 경감제 - Google Patents
신독성 경감제 Download PDFInfo
- Publication number
- KR20240035502A KR20240035502A KR1020247003682A KR20247003682A KR20240035502A KR 20240035502 A KR20240035502 A KR 20240035502A KR 1020247003682 A KR1020247003682 A KR 1020247003682A KR 20247003682 A KR20247003682 A KR 20247003682A KR 20240035502 A KR20240035502 A KR 20240035502A
- Authority
- KR
- South Korea
- Prior art keywords
- nephrotoxicity
- antisense oligomer
- sugar
- pharmaceutical composition
- antisense
- Prior art date
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Classifications
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
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- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- C—CHEMISTRY; METALLURGY
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
Landscapes
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| PCT/JP2022/027104 WO2023282345A1 (ja) | 2021-07-08 | 2022-07-08 | 腎毒性軽減剤 |
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Citations (3)
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| WO2002036767A2 (en) | 2000-11-02 | 2002-05-10 | Inex Pharmaceuticals Corporation | Therapeutic oligonucleotides of reduced toxicity |
| WO2010009038A2 (en) | 2008-07-18 | 2010-01-21 | Oncogenex Technologies Inc. | Antisense formulation |
| JP2015091229A (ja) | 2013-10-04 | 2015-05-14 | 国立大学法人神戸大学 | 福山型筋ジストロフィー治療用アンチセンス核酸 |
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| EP0962463B1 (en) | 1989-12-20 | 2002-07-10 | Antivirals Inc. | Uncharged morpholino-based polymers having phosphorus-containing chiral intersubunit linkages |
| JPWO2006038608A1 (ja) | 2004-10-05 | 2008-05-15 | 日本新薬株式会社 | オリゴ二本鎖ｒｎａ及び医薬組成物 |
| EP1811960A2 (en) * | 2004-11-19 | 2007-08-01 | Novosom AG | Improvements in or relating to pharmaceutical compositions for local administration |
| WO2006129594A1 (ja) | 2005-05-30 | 2006-12-07 | Nippon Shinyaku Co., Ltd. | 核酸含有複合体製剤の製造方法 |
| ES2657400T3 (es) | 2006-05-10 | 2018-03-05 | Sarepta Therapeutics, Inc. | Análogos de oligonucleótidos que tienen enlaces intersubunitarios catiónicos |
| CN1868456A (zh) * | 2006-06-25 | 2006-11-29 | 沈阳药科大学 | 反义脱氧寡核苷酸isis23665脂质体制剂及制备方法 |
| WO2009005793A2 (en) | 2007-06-29 | 2009-01-08 | Avi Biopharma, Inc. | Tissue specific peptide conjugates and methods |
| CA2884340C (en) | 2007-11-15 | 2017-07-25 | Sarepta Therapeutics, Inc. | Method of synthesis of morpholino oligomers |
| CA2930393C (en) | 2007-12-04 | 2022-11-29 | Alnylam Pharmaceuticals, Inc. | Carbohydrate conjugates as delivery agents for oligonucleotides |
| CN103619356B (zh) | 2011-05-05 | 2017-09-12 | 萨勒普塔医疗公司 | 肽寡核苷酸缀合物 |
| CN102989007B (zh) * | 2011-06-29 | 2015-12-16 | 湖州市中心医院 | 大规模制备注射用中期因子反义寡核苷酸纳米脂质体的方法 |
| SG11201402392QA (en) | 2011-11-18 | 2014-06-27 | Alnylam Pharmaceuticals Inc | Rnai agents, compositions and methods of use thereof for treating transthyretin (ttr) associated diseases |
| RU2619184C2 (ru) | 2011-12-28 | 2017-05-12 | Ниппон Синяку Ко., Лтд. | Антисмысловые нуклеиновые кислоты |
| RU2019110030A (ru) | 2013-05-01 | 2019-05-06 | Ионис Фармасьютикалз, Инк. | Композиции и способы |
| CA2917161C (en) | 2013-07-11 | 2023-12-12 | Alnylam Pharmaceuticals, Inc. | Oligonucleotide-ligand conjugates and process for their preparation |
| US9856496B2 (en) | 2013-12-12 | 2018-01-02 | Life Technologies Corporation | Membrane-penetrating peptides to enhance transfection and compositions and methods for using same |
| JP6482475B2 (ja) | 2014-01-07 | 2019-03-13 | レナセラピューティクス株式会社 | アンチセンスオリゴヌクレオチド及び糖誘導体を含む二本鎖オリゴヌクレオチド |
| WO2016187425A1 (en) | 2015-05-19 | 2016-11-24 | Sarepta Therapeutics, Inc. | Peptide oligonucleotide conjugates |
| US20180193471A1 (en) | 2015-07-16 | 2018-07-12 | Kyowa Hakko Kirin Co., Ltd. | ß2GPI GENE EXPRESSION-SUPPRESSING NUCLEIC ACID CONJUGATE |
| SI3554554T1 (sl) | 2016-12-19 | 2023-02-28 | Sarepta Therapeutics, Inc. | Oligomerni konjugati, ki preskakujejo ekson za mišično distrofijo |
| WO2018118599A1 (en) | 2016-12-19 | 2018-06-28 | Sarepta Therapeutics, Inc. | Exon skipping oligomer conjugates for muscular dystrophy |
| HUE059905T2 (hu) | 2016-12-19 | 2023-01-28 | Sarepta Therapeutics Inc | Exonátugró oligomerkonjugátumok izomdisztrófiára |
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| WO2002036767A2 (en) | 2000-11-02 | 2002-05-10 | Inex Pharmaceuticals Corporation | Therapeutic oligonucleotides of reduced toxicity |
| WO2010009038A2 (en) | 2008-07-18 | 2010-01-21 | Oncogenex Technologies Inc. | Antisense formulation |
| JP2015091229A (ja) | 2013-10-04 | 2015-05-14 | 国立大学法人神戸大学 | 福山型筋ジストロフィー治療用アンチセンス核酸 |
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| EP4368186A1 (en) | 2024-05-15 |
| TW202337473A (zh) | 2023-10-01 |
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| IL310003A (en) | 2024-03-01 |
| WO2023282345A1 (ja) | 2023-01-12 |
| CA3225454A1 (en) | 2023-01-12 |
| JPWO2023282345A1 (pt) | 2023-01-12 |
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