KR20240011272A - Functional composition comprising herbal medicine as an active ingredient - Google Patents
Functional composition comprising herbal medicine as an active ingredient Download PDFInfo
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- KR20240011272A KR20240011272A KR1020220087926A KR20220087926A KR20240011272A KR 20240011272 A KR20240011272 A KR 20240011272A KR 1020220087926 A KR1020220087926 A KR 1020220087926A KR 20220087926 A KR20220087926 A KR 20220087926A KR 20240011272 A KR20240011272 A KR 20240011272A
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- composition
- present
- perilla
- oil
- acid
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Classifications
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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- A—HUMAN NECESSITIES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/30—Boraginaceae (Borage family), e.g. comfrey, lungwort or forget-me-not
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Abstract
본 발명은 한약재를 유효성분으로 포함하는 기능성 조성물에 관한 것으로, 더욱 구체적으로는 한약재인 자초(Lithospermi Radix), 당귀(Angelica gigas), 감초(Glycyrrhiza glabra), 백작약(Paeonia lactiflora), 자소엽(Perillae Folium), 금은화(Lonicerae Flos), 연교(Forsythiae Fructus), 유백피(Ulmi Cortex) 및 황련(Coptidis Rhizoma) 혼합 추출물을 이용한 기능성 조성물에 관한 것이다. 상기 조성물은 피부각질형성세포, 염증관련 대식세포 및 면역관련 비만세포에서 무독성을 가지며, 항산화 효과, 면역증강 효과, 항염증 효과, 항알러지 효과, 항균 효과, 여드름 치료 효과 및 보습과 피부장벽 강화 효과를 가지는 것을 확인하였다. 이는 화장료 조성물, 건강기능식품 조성물 또는 약학 조성물로 사용될 수 있다.The present invention relates to a functional composition containing herbal medicine as an active ingredient, and more specifically, to a functional composition containing herbal medicine as an active ingredient, such as Lithospermi Radix , Angelica gigas , G lycyrrhiza glabra , Paeonia lactiflora , and Perilla leaf ( It relates to a functional composition using mixed extracts of Perillae Folium , Lonicerae Flos , Forsythiae Fructus , Ulmi Cortex , and Coptidis Rhizoma . The composition is non-toxic to skin keratinocytes, inflammation-related macrophages, and immune-related mast cells, and has antioxidant, immune-boosting, anti-inflammatory, anti-allergic, antibacterial, acne treatment, moisturizing, and skin barrier strengthening effects. I confirmed that I have it. It can be used as a cosmetic composition, health functional food composition, or pharmaceutical composition.
Description
본 발명은 한약재를 유효성분으로 포함하는 기능성 조성물에 관한 것으로, 더욱 구체적으로는 한약재인 자초 (Lithospermi Radix), 당귀 (Angelica gigas), 감초 (Glycyrrhiza glabra), 백작약 (Paeonia lactiflora), 자소엽 (Perillae Folium), 금은화 (Lonicerae Flos), 연교 (Forsythiae Fructus), 유백피 (Ulmi Cortex) 및 황련 (Coptidis Rhizoma) 혼합 추출물을 이용한 기능성 조성물에 관한 것이다. 상기 조성물은 화장료 조성물, 건강기능식품 조성물 또는 약학 조성물로 사용될 수 있다.The present invention relates to a functional composition containing herbal medicine as an active ingredient, and more specifically, to a functional composition containing herbal medicine as an active ingredient, such as Lithospermi Radix , Angelica gigas , G lycyrrhiza glabra , Paeonia lactiflora , and Perilla leaf ( It relates to a functional composition using mixed extracts of Perillae Folium , Lonicerae Flos , Forsythiae Fructus , Ulmi Cortex , and Coptidis Rhizoma . The composition can be used as a cosmetic composition, health functional food composition, or pharmaceutical composition.
피부는 신체조직 중 가장 큰 기관으로 항상 외부와 접하고 있으면서 여러 가지 외부 자극이나 건조한 환경으로부터 생체를 보호하는 보호막 역할을 하고 있으며, 다른 기관에 비하여 새로운 세포의 생성과 소멸이 활발히 일어나는 기관이다. 또한 몸 안에 가지고 있는 수분의 손실을 막아주며 태양광선으로부터 나오는 해로운 자외선으로부터 보호해주는 중요한 역할을 담당하고 있다.The skin is the largest organ in the body and is always in contact with the outside world. It acts as a protective layer to protect the living body from various external stimuli or dry environments. Compared to other organs, the skin is an organ where the creation and extinction of new cells occurs more actively. It also plays an important role in preventing loss of moisture in the body and protecting against harmful ultraviolet rays from the sun.
또한, 우리 인체는 외부 환경과 밀접하게 접하고 있고 환경 오염, 유해 물질, 스트레스, 불규칙한 생활 습관 등에 의해 쉽게 민감화 된다. 이러한 외부환경에 의해 노출된 피부는 활성 산소 즉, 프리라디칼이 발생되고 발생된 활성 산소와 프리라디칼은 정상적인 세포 조직이나 세포막을 공격하여 세포가 파괴되고 피부는 결국 염증을 일으키게 된다. 염증화된 조직은 피부의 생리학적 메카니즘에 의해 단백질이나 유전자 물질 등을 파괴하여 피부 트러블뿐만 아니라 아토피 피부염, 피부노화 등을 일으키는 주요 원인이 되고 있다. 또한 피부가 자외선에 과다 노출되면 티로시나제의 작용으로 멜라노좀에서 멜라닌 합성이 촉진되어 피부노화가 빠르게 진행되고, 이때 생성된 프리라디칼이 지질, 단백질, 당 및 핵산을 손상시키고 세포막의 파괴에 관여함으로써 돌연변이를 유발시키고, 피부암을 발생시킨다.Additionally, our human body is in close contact with the external environment and is easily sensitized by environmental pollution, harmful substances, stress, and irregular lifestyle habits. The skin exposed to this external environment generates free radicals, and the generated free radicals attack normal cell tissue or cell membranes, destroying the cells and eventually causing inflammation in the skin. Inflamed tissue destroys proteins and genetic materials through the skin's physiological mechanism, becoming a major cause of not only skin troubles but also atopic dermatitis and skin aging. In addition, when the skin is overexposed to ultraviolet rays, melanin synthesis is promoted in melanosomes due to the action of tyrosinase, causing rapid skin aging. Free radicals generated at this time damage lipids, proteins, sugars, and nucleic acids and participate in the destruction of cell membranes, leading to mutations. and causes skin cancer.
이러한 피부상태의 문제점을 개선하기 위하여 우선적으로 주위 생활환경을 개선하는 것이 중요하지만, 부수적으로 기능을 상실한 피부를 정상화 시키기 위하여 다양한 방법이 필요하다. 이에 피부 상태를 개선하는데 도움을 주는 여러 가지의 한약재 성분들을 함유한 화장료가 개발되어 건강한 피부를 유지시키는데 이용되고 있다. 하지만 한약재가 함유된 화장료라도 효과가 정확하게 규명되지 않은 제품을 사용하는 것은 오히려 소비자들에게 악영향을 끼칠 수 있으므로 화장품에 적용하기 전에 이러한 한약재의 피부와 관련된 다양한 활성 검증이 필요하다.In order to improve these skin conditions, it is important to first improve the surrounding living environment, but various methods are necessary to normalize skin that has lost its function. Accordingly, cosmetics containing various herbal ingredients that help improve skin condition have been developed and are used to maintain healthy skin. However, even cosmetics containing herbal medicines, using products whose effects are not accurately identified can have a negative impact on consumers, so it is necessary to verify various skin-related activities of these herbal medicines before applying them to cosmetics.
따라서 본 발명은 한약재를 유효성분으로 포함하는 기능성 조성물에 관한 것으로, 더욱 구체적으로는 한약재인 자초, 당귀, 감초, 백작약, 자소엽, 금은화, 연교, 유백피 및 황련 혼합 추출물을 이용한 기능성 조성물에 관한 것이다. 상기 조성물은 피부각질형성세포, 염증관련세포 및 면역관련세포에서 무독성을 가지며, 항산화 효과, 면역증강 효과, 항염증 효과, 항알러지 효과, 항균 효과, 여드름 치료 효과 및 보습과 피부장벽 강화 효과를 가지는 것을 확인하였으므로 화장료 조성물, 건강기능식품 조성물 또는 약학 조성물로 사용될 수 있다.Therefore, the present invention relates to a functional composition containing herbal medicines as active ingredients, and more specifically, to a functional composition using mixed extracts of herbal medicines such as Poria chinensis, Angelica root, Licorice root, Peony chinensis, Perilla leaves, Honeysuckle, Lotus root, Milky bark and Yellow lotus. will be. The composition is non-toxic to skin keratinocytes, inflammation-related cells, and immune-related cells, and has antioxidant, immune-boosting, anti-inflammatory, anti-allergic, anti-bacterial, acne treatment, moisturizing, and skin barrier strengthening effects. Since it has been confirmed, it can be used as a cosmetic composition, health functional food composition, or pharmaceutical composition.
본 발명의 목적은 한약재를 유효성분으로 포함하는 기능성 화장료 조성물을 제공하는 데 있다.The purpose of the present invention is to provide a functional cosmetic composition containing herbal medicine as an active ingredient.
또한, 본 발명의 다른 목적은 한약재를 유효성분으로 포함하는 건강기능식품 조성물을 제공하는 데 있다.In addition, another object of the present invention is to provide a health functional food composition containing herbal medicine as an active ingredient.
마지막으로, 본 발명의 다른 목적은 한약재를 유효성분으로 포함하는 약학 조성물을 제공하는 데 있다.Lastly, another object of the present invention is to provide a pharmaceutical composition containing herbal medicine as an active ingredient.
상기와 같은 목적을 달성하기 위해, 본 발명은 자초, 당귀, 감초, 백작약, 자소엽, 금은화, 연교, 유백피 및 황련 혼합 추출물을 유효성분으로 포함하는 항산화, 면역증강, 항염증, 항알러지, 항균, 여드름 개선 및 보습과 피부장벽 강화용 기능성 화장료 조성물을 제공한다.In order to achieve the above object, the present invention provides antioxidant, immune-boosting, anti-inflammatory, anti-allergic, Provides functional cosmetic compositions for antibacterial, acne improvement, moisturizing, and skin barrier strengthening.
본 발명의 일 실시예에 있어서, 상기 조성물은 피부각질형성세포, 염증관련 대식세포 및 면역관련 비만세포에서 무독성을 가지는 것일 수 있다.In one embodiment of the present invention, the composition may be non-toxic to skin keratinocytes, inflammation-related macrophages, and immune-related mast cells.
본 발명의 일 실시예에 있어서, 상기 추출물은 오일로 추출된 것일 수 있으며, 상기 오일은 올리브오일, 카놀라오일, 해바라기씨오일 또는 포도씨오일을 추출용매로 사용한 것일 수 있으나 이에 한정되는 것은 아니다.In one embodiment of the present invention, the extract may be extracted with oil, and the oil may be one using olive oil, canola oil, sunflower seed oil, or grape seed oil as an extraction solvent, but is not limited thereto.
본 발명의 일 실시예에 있어서, 상기 조성물은 자초, 당귀, 감초, 백작약, 자소엽, 금은화, 연교, 유백피 및 황련을 포도씨오일에 침적한 후, 200 내지 300℃에서 추출하는 것일 수 있으나 이에 한정되는 것은 아니다.In one embodiment of the present invention, the composition may be prepared by immersing Japanese herb, angelica root, licorice, white peony, perilla leaves, honeysuckle, lotus root, milky white bark, and yellow lotus in grape seed oil, and then extracting them at 200 to 300°C. It is not limited.
본 발명의 일 실시예에 있어서, 상기 조성물은 DPPH 활성산소 소거능을 가지는 것일 수 있으나 이에 한정되는 것은 아니다.In one embodiment of the present invention, the composition may have DPPH oxygen radical scavenging ability, but is not limited thereto.
본 발명의 일 실시예에 있어서, 상기 조성물은 Nitric oxide (NO)를 증가시키는 것일 수 있으나 이에 한정되는 것은 아니다.In one embodiment of the present invention, the composition may increase nitric oxide (NO), but is not limited thereto.
본 발명의 일 실시예에 있어서, 상기 조성물은 COX-2, TNF-α 및 iNOS의 생성을 억제시키는 것일 수 있으나 이에 한정되는 것은 아니다.In one embodiment of the present invention, the composition may inhibit the production of COX-2, TNF-α, and iNOS, but is not limited thereto.
본 발명의 일 실시예에 있어서, 상기 조성물은 Fillagrin 및 Loricrin을 증가시키는 것일 수 있으나 이에 한정되는 것은 아니다.In one embodiment of the present invention, the composition may increase Fillagrin and Loricrin, but is not limited thereto.
본 발명의 일 실시예에 있어서, 상기 조성물은 히스타민 분비효소를 억제시키는 것일 수 있으나 이에 한정되는 것은 아니다.In one embodiment of the present invention, the composition may inhibit histamine secreting enzyme, but is not limited thereto.
본 발명의 일 실시예에 있어서, 상기 조성물은 여드름균 (Propionibacterium acnes), 황색포도상구균 (Staphylococcus aureus) 및 대장균 (Escherichia coli)의 증식을 억제시키는 것일 수 있으나 이에 한정되는 것은 아니다.In one embodiment of the present invention, the composition may inhibit the growth of Propionibacterium acnes , Staphylococcus aureus , and Escherichia coli , but is not limited thereto.
또한, 본 발명은 자초, 당귀, 감초, 백작약, 자소엽, 금은화, 연교, 유백피 및 황련 혼합 추출물을 유효성분으로 포함하는 항산화, 면역증강, 항염증, 항알러지, 항균, 여드름 개선 및 보습과 피부장벽 강화용 건강기능식품 조성물을 제공한다.In addition, the present invention provides anti-oxidation, immunity enhancement, anti-inflammatory, anti-allergy, anti-bacterial, acne improvement, moisturizing and skin treatment containing as active ingredients the extracts of herbacea, angelica root, licorice, white peony, perilla leaf, honeysuckle, perilla, milky bark and yellow lotus mixed extract. Provides a health functional food composition for strengthening the barrier.
마지막으로, 본 발명은 자초, 당귀, 감초, 백작약, 자소엽, 금은화, 연교, 유백피 및 황련 혼합 추출물을 유효성분으로 포함하는 여드름 예방 또는 치료용 약학 조성물을 제공한다.Finally, the present invention provides a pharmaceutical composition for preventing or treating acne containing mixed extracts of chinensis, angelica root, licorice, white peony, perilla leaf, honeysuckle, perilla, milky bark and yellow lotus mixed extract as active ingredients.
본 발명은 한약재를 유효성분으로 포함하는 기능성 조성물에 관한 것으로, 더욱 구체적으로는 한약재인 자초, 당귀, 감초, 백작약, 자소엽, 금은화, 연교, 유백피 및 황련 혼합 추출물을 이용한 기능성 조성물에 관한 것이다. 상기 조성물은 피부각질형성세포, 염증관련 대식세포 및 면역관련 비만세포에서 무독성을 가지며, 항산화 효과, 면역증강 효과, 항염증 효과, 항알러지 효과, 항균 효과, 여드름 치료 효과 및 보습과 피부장벽 강화 효과를 가지는 것을 확인하였다.The present invention relates to a functional composition containing herbal medicines as active ingredients, and more specifically, to a functional composition using mixed extracts of herbal medicines such as Japanese herb, Angelica root, licorice, Paeonia, perilla leaves, honeysuckle, lotus root, milky white bark, and yellow lotus. . The composition is non-toxic to skin keratinocytes, inflammation-related macrophages, and immune-related mast cells, and has antioxidant, immune-boosting, anti-inflammatory, anti-allergic, antibacterial, acne treatment, moisturizing, and skin barrier strengthening effects. I confirmed that I have it.
도 1은 본 발명의 일 실시예에 있어서, 본 발명의 한약재 혼합 추출물(TB2)의 피부각질형성세포, 염증관련 대식세포 및 면역관련 비만세포에서 무독성을 나타낸 도이다.
도 2는 본 발명의 일 실시예에 있어서, 본 발명의 한약재 혼합 추출물(TB2)의 항산화 효과를 나타낸 도이다.
도 3은 본 발명의 일 실시예에 있어서, 본 발명의 한약재 혼합 추출물(TB2)의 면역증강 효과를 나타낸 도이다.
도 4는 본 발명의 일 실시예에 있어서, 본 발명의 한약재 혼합 추출물(TB2)의 항염증 효과를 나타낸 도이다.
도 5는 본 발명의 일 실시예에 있어서, 본 발명의 한약재 혼합 추출물(TB2)의 항알러지 효과를 나타낸 도이다.
도 6은 본 발명의 일 실시예에 있어서, 본 발명의 한약재 혼합 추출물(TB2)의 여드름균, 황색포도상구균 및 대장균에 대한 항여드름균 및 항균 효과를 나타낸 도이다.
도 7은 본 발명의 일 실시예에 있어서, 본 발명의 한약재 혼합 추출물(TB2)의 보습과 피부장벽 강화 효과를 나타낸 도이다.Figure 1 is a diagram showing the non-toxicity of the herbal medicine mixed extract (TB2) of the present invention on skin keratinocytes, inflammation-related macrophages, and immune-related mast cells, in one embodiment of the present invention.
Figure 2 is a diagram showing the antioxidant effect of the herbal medicine mixed extract (TB2) of the present invention in one embodiment of the present invention.
Figure 3 is a diagram showing the immune-enhancing effect of the herbal medicine mixed extract (TB2) of the present invention in one embodiment of the present invention.
Figure 4 is a diagram showing the anti-inflammatory effect of the herbal medicine mixed extract (TB2) of the present invention in one embodiment of the present invention.
Figure 5 is a diagram showing the anti-allergy effect of the herbal medicine mixed extract (TB2) of the present invention in one embodiment of the present invention.
Figure 6 is a diagram showing the anti-acne bacteria and antibacterial effects of the herbal medicine mixed extract (TB2) of the present invention on Acne acne, Staphylococcus aureus, and Escherichia coli in one embodiment of the present invention.
Figure 7 is a diagram showing the moisturizing and skin barrier strengthening effects of the herbal medicine mixed extract (TB2) of the present invention in one embodiment of the present invention.
이하, 첨부된 도면을 참조하여 본 발명의 실시예로 본 발명을 상세히 설명하기로 한다. 다만, 하기 실시예는 본 발명에 대한 예시로 제시되는 것으로, 당업자에게 주지 저명한 기술 또는 구성에 대한 구체적인 설명이 본 발명의 요지를 불필요하게 흐릴 수 있다고 판단되는 경우에는 그 상세한 설명을 생략할 수 있고, 이에 의해 본 발명이 제한되지는 않는다. 본 발명은 후술하는 특허 청구범위의 기재 및 그로부터 해석되는 균등 범주 내에서 다양한 변형 및 응용이 가능하다.Hereinafter, the present invention will be described in detail through embodiments of the present invention with reference to the attached drawings. However, the following examples are provided as examples of the present invention, and if it is judged that a detailed description of a technology or configuration well known to those skilled in the art may unnecessarily obscure the gist of the present invention, the detailed description may be omitted. , the present invention is not limited thereby. The present invention is capable of various modifications and applications within the description of the patent claims described below and the scope of equivalents interpreted therefrom.
또한, 본 명세서에서 사용되는 용어 (Terminology)들은 본 발명의 바람직한 실시 예를 적절히 표현하기 위해 사용된 용어들로서, 이는 사용자, 운용자의 의도 또는 본 발명이 속하는 분야의 관례 등에 따라 달라질 수 있다. 따라서 본 용어들에 대한 정의는 본 명세서 전반에 걸친 내용을 토대로 내려져야 할 것이다. 명세서 전체에서, 어떤 부분이 어떤 구성요소를 “포함”한다고 할 때, 이는 특별히 반대되는 기재가 없는 한 다른 구성요소를 제외하는 것이 아니라 다른 구성 요소를 더 포함할 수 있는 것을 의미한다.In addition, terminology used in this specification is a term used to appropriately express preferred embodiments of the present invention, and may vary depending on the intention of the user or operator or the customs of the field to which the present invention belongs. Therefore, definitions of these terms should be made based on the content throughout this specification. Throughout the specification, when it is said that a part “includes” a certain element, this means that it may further include other elements rather than excluding other elements, unless specifically stated to the contrary.
본 명세서 전체에 걸쳐, 특정 물질의 농도를 나타내기 위하여 사용되는 '%'는 별도의 언급이 없는 경우, 고체/고체는 (w/w) %, 고체/액체는 (w/v) %, 그리고 액체/액체는 (v/v) %이다.Throughout this specification, '%' used to indicate the concentration of a specific substance means (w/w) % for solid/solid, (w/v) % for solid/liquid, and Liquid/liquid is (v/v) %.
본 발명에 따른 추출물은 당업계에 공지된 추출 및 분리방법을 사용하여 천연으로부터 추출 및 분리하여 수득한 것을 사용할 수 있으며, 본 발명에서 정의된 "추출물"은 적절한 용매를 이용하여 자초, 당귀, 감초, 백작약, 자소엽, 금은화, 연교, 유백피 및 황련으로부터 추출한 것이며, 예를 들어, 조추출물, 극성용매 가용 추출물 또는 비극성용매 가용 추출물을 모두 포함한다. 상기 자초, 당귀, 감초, 백작약, 자소엽, 금은화, 연교, 유백피 및 황련으로부터 추출물을 추출하기 위한 적절한 용매로는 약학적으로 허용되는 유기용매라면 어느 것을 사용해도 무방하며, 물 또는 유기용매를 사용할 수 있으며, 이에 제한되지는 않으나, 예를 들어, 정제수, 메탄올 (methanol), 에탄올 (ethanol), 프로판올 (propanol), 이소프로판올 (isopropanol), 부탄올 (butanol) 등을 포함하는 탄소수 1 내지 4의 알코올, 아세톤 (acetone), 에테르 (ether), 벤젠 (benzene), 클로로포름 (chloroform), 에틸아세테이트 (ethyl acetate), 메틸렌클로라이드 (methylene chloride), 헥산 (hexane) 및 시클로헥산 (cyclohexane) 등의 각종 용매를 단독으로 혹은 혼합하여 사용할 수 있다. 추출 방법으로는 열수추출법, 냉침추출법, 환류냉각추출법, 용매추출법, 수증기증류법, 초음파추출법, 용출법, 압착법, 초임계추출법 등의 방법 중 어느 하나를 선택하여 사용할 수 있다. 또한, 목적하는 추출물은 추가로 통상의 분획 공정을 수행할 수도 있으며, 통상의 정제 방법을 이용하여 정제될 수도 있다.The extract according to the present invention can be obtained by extraction and separation from nature using extraction and separation methods known in the art. , peony, perilla leaf, honeysuckle, lotus root, milky white bark, and yellow lotus, and includes, for example, crude extract, polar solvent-soluble extract, or non-polar solvent-soluble extract. Any pharmaceutically acceptable organic solvent may be used as an appropriate solvent for extracting extracts from the above-mentioned herbacea, angelica root, licorice, peony, perilla leaves, honeysuckle, perilla, milky bark, and yellow lotus. Water or an organic solvent may be used as an appropriate solvent. It can be used, but is not limited thereto, for example, purified water, methanol, ethanol, propanol, isopropanol, butanol, and alcohol having 1 to 4 carbon atoms, including , acetone, ether, benzene, chloroform, ethyl acetate, methylene chloride, hexane, and cyclohexane. It can be used alone or in combination. As an extraction method, any one of the following methods can be selected and used: hot water extraction, cold needle extraction, reflux cooling extraction, solvent extraction, steam distillation, ultrasonic extraction, dissolution, compression, and supercritical extraction. In addition, the desired extract may be further subjected to a conventional fractionation process or may be purified using a conventional purification method.
본 발명의 추출물의 제조방법에는 제한이 없으며, 공지되어 있는 어떠한 방법도 이용될 수 있다. 예를 들면, 본 발명의 조성물에 포함되는 추출물은 상기한 열수 추출 또는 용매 추출법으로 추출된 1차 추출물을, 감압 증류 및 동결 건조 또는 분무 건조 등과 같은 추가적인 과정에 의해 분말상태로 제조할 수 있다. 또한 상기 1차 추출물을 실리카겔 컬럼 크로마토그래피 (silica gel column chromatography), 박층 크로마토그래피 (thin layer chromatography), 고성능 액체 크로마토그래피 (high performance liquid chromatography) 등과 같은 다양한 크로마토그래피를 이용하여 추가로 정제된 분획을 얻을 수도 있다. 따라서 본 발명에 있어서 추출물은 추출, 분획 또는 정제의 각 단계에서 얻어지는 모든 추출액, 분획 및 정제물, 그들의 희석액, 농축액 또는 건조물을 모두 포함하는 개념이다.There is no limitation to the method for producing the extract of the present invention, and any known method can be used. For example, the extract included in the composition of the present invention can be prepared in powder form from the primary extract extracted by the above-described hot water extraction or solvent extraction method by additional processes such as reduced pressure distillation and freeze-drying or spray drying. In addition, the primary extract was further purified into fractions using various chromatographies such as silica gel column chromatography, thin layer chromatography, and high performance liquid chromatography. You can also get it. Therefore, in the present invention, extract is a concept that includes all extracts, fractions, and purifications obtained at each stage of extraction, fractionation, or purification, as well as their dilutions, concentrates, or dried products.
바람직하게는 자초, 당귀, 감초, 백작약, 자소엽, 금은화, 연교, 유백피 및 황련 혼합 추출물을 유효성분으로 포함하는 항산화, 면역증강, 항염증, 항알러지, 항균, 여드름 개선 및 보습과 피부장벽 강화용 기능성 화장료 조성물을 제조 시 오일로 추출된 것일 수 있으며, 상기 오일은 올리브오일, 카놀라오일, 해바라기씨오일 또는 포도씨오일을 이용할 수 있다.Preferably, it contains as active ingredients extracts of Japanese herb, angelica root, licorice, white peony, perilla leaf, honeysuckle, lotus root, milky white bark, and yellow lotus mixed extract as active ingredients for antioxidant, immune-boosting, anti-inflammatory, anti-allergic, antibacterial, acne improvement, moisturizing, and skin barrier strengthening. When manufacturing a functional cosmetic composition for use, it may be extracted as oil, and the oil may be olive oil, canola oil, sunflower seed oil, or grape seed oil.
일 측면에서, 본 발명은 자초, 당귀, 감초, 백작약, 자소엽, 금은화, 연교, 유백피 및 황련 혼합 추출물을 유효성분으로 포함하는 항산화, 면역증강, 항염증, 항알러지, 항균, 여드름 개선 및 보습과 피부장벽 강화용 기능성 화장료 조성물을 제공한다.In one aspect, the present invention provides anti-oxidation, immunity enhancement, anti-inflammatory, anti-allergy, antibacterial, acne improvement and Provides a functional cosmetic composition for moisturizing and strengthening the skin barrier.
본 발명의 기능성 화장료 조성물은 항산화, 면역증강, 항염증, 항알러지, 항균, 여드름 개선 및 보습과 피부장벽 강화 등에 다양하게 이용될 수 있다. 본 조성물을 첨가할 수 있는 제품으로는, 예를 들어, 각종 크림, 로션, 스킨, 에센스 등과 같은 화장품류와 샴푸, 린스, 클렌징, 세안제, 비누, 트리트먼트, 팩, 미용액 등이 있다.The functional cosmetic composition of the present invention can be used in a variety of ways, such as antioxidant, immune-boosting, anti-inflammatory, anti-allergic, antibacterial, acne improvement, moisturizing, and skin barrier strengthening. Products to which this composition can be added include, for example, cosmetics such as various creams, lotions, skins, and essences, as well as shampoos, rinses, cleansers, face washes, soaps, treatments, packs, and beauty essences.
본 발명의 화장료 조성물은 수용성 비타민, 유용성 비타민, 고분자 펩티드, 고분자 다당, 스핑고 지질 및 해초 추출물로 이루어진 군에서 선택된 조성물을 포함한다.The cosmetic composition of the present invention includes a composition selected from the group consisting of water-soluble vitamins, oil-soluble vitamins, high molecular weight peptides, high molecular weight polysaccharides, sphingolipids, and seaweed extracts.
수용성 비타민으로서는 화장품에 배합 가능한 것이라면 어떠한 것이라도 되지만, 바람직하게는 비타민 B1, 비타민 B2, 비타민 B6, 피리독신, 염산피리독신, 비타민 B12, 판토텐산, 니코틴산, 니코틴산아미드, 엽산, 비타민 C, 비타민 H 등을 들 수 있으며, 그들의 염 (티아민염산염, 아스코르빈산나트륨염 등)이나 유도체 (아스코르빈산-2-인산나트륨염, 아스코르빈산-2-인산마그네슘염 등)도 본 발명에서 사용할 수 있는 수용성 비타민에 포함된다. 수용성 비타민은 미생물 변환법, 미생물의 배양물로부터의 정제법, 효소법 또는 화학 합성법 등의 통상의 방법에 의해 수득할 수 있다.Water-soluble vitamins may be any that can be mixed into cosmetics, but preferably include vitamin B1, vitamin B2, vitamin B6, pyridoxine, pyridoxine hydrochloride, vitamin B12, pantothenic acid, nicotinic acid, nicotinic acid amide, folic acid, vitamin C, and vitamin H. and their salts (thiamine hydrochloride, sodium ascorbate, etc.) or derivatives (sodium ascorbic acid-2-phosphate, magnesium ascorbic acid-2-phosphate, etc.) are also water-soluble vitamins that can be used in the present invention. Included. Water-soluble vitamins can be obtained by conventional methods such as microbial transformation, purification from microbial cultures, enzymatic methods, or chemical synthesis.
유용성 비타민으로서는 화장품에 배합 가능한 것이라면 어떠한 것이라도 되지만, 바람직하게는 비타민 A, 카로틴, 비타민 D2, 비타민 D3, 비타민 E (d1-알파 토코페롤, d-알파 토코페롤, d-알파 토코페롤) 등을 들 수 있으며, 그들의 유도체(팔미틴산아스코르빈, 스테아르산아스코르빈, 디팔미틴산아스코르빈, 아세트산dl-알파 토코페롤, 니코틴산dl-알파 토코페롤비타민 E, DL-판토테닐알코올, D-판토테닐알코올, 판토테닐에틸에테르 등) 등도 본 발명에서 사용되는 유용성 비타민에 포함된다. 유용성 비타민은 미생물 변환법, 미생물의 배양물로부터의 정제법, 효소 또는 화학 합성법 등의 통상의 방법에 의해 취득할 수 있다.Oil-soluble vitamins may be any that can be mixed into cosmetics, but preferably include vitamin A, carotene, vitamin D2, vitamin D3, vitamin E (d1-alpha tocopherol, d-alpha tocopherol, d-alpha tocopherol), etc. , their derivatives (ascorbic palmitate, ascorbic stearate, ascorbic acid dipalmitate, dl-alpha tocopherol acetate, dl-alpha tocopherol nicotinic acid, vitamin E, DL-pantothenyl alcohol, D-pantothenyl alcohol, pantothenyl ethyl ether, etc.) are also included in the oil-soluble vitamins used in the present invention. Oil-soluble vitamins can be obtained by conventional methods such as microbial transformation, purification from microbial cultures, enzymatic or chemical synthesis.
고분자 펩티드로서는 화장품에 배합 가능한 것이라면 어떠한 것이라도 되지만, 바람직하게는 콜라겐, 가수 분해 콜라겐, 젤라틴, 엘라스틴, 가수 분해 엘라스틴, 케라틴 등을 들 수 있다. 고분자 펩티드는 미생물의 배양액으로부터의 정제법, 효소법 또는 화학 합성법 등의 통상의 방법에 의해 정제 취득할 수 있으며, 또는 통상 돼지나 소 등의 진피, 누에의 견섬유 등의 천연물로부터 정제하여 사용할 수 있다.The polymer peptide may be any peptide that can be blended into cosmetics, but preferably includes collagen, hydrolyzed collagen, gelatin, elastin, hydrolyzed elastin, and keratin. High molecular weight peptides can be purified and obtained by conventional methods such as purification from microbial culture media, enzymatic methods, or chemical synthesis, or they can usually be purified and used from natural products such as dermis of pigs or cows or silk fiber of silkworms.
고분자 다당으로서는 화장품에 배합 가능한 것이라면 어떠한 것이라도 되지만, 바람직하게는 히드록시에틸셀룰로오스, 크산탄검, 히알루론산나트륨, 콘드로이틴 황산 또는 그 염 (나트륨염 등) 등을 들 수 있다. 예를 들어, 콘드로이틴 황산 또는 그 염 등은 통상 포유 동물이나 어류로부터 정제하여 사용할 수 있다.The high molecular polysaccharide may be any one that can be blended into cosmetics, but preferably includes hydroxyethyl cellulose, xanthan gum, sodium hyaluronate, chondroitin sulfate or its salts (sodium salt, etc.). For example, chondroitin sulfate or its salt can usually be purified and used from mammals or fish.
스핑고 지질로서는 화장품에 배합 가능한 것이라면 어떠한 것이라도 되지만, 바람직하게는 세라미드, 피토스핑고신, 스핑고당지질 등을 들 수 있다. 스핑고 지질은 통상 포유류, 어류, 패류, 효모 또는 식물 등으로부터 통상의 방법에 의해 정제하거나 화학 합성법에 의해 취득할 수 있다.The sphingolipid may be any one that can be incorporated into cosmetics, but preferably includes ceramide, phytosphingosine, and sphingolipid. Sphingolipids can usually be purified by conventional methods from mammals, fish, shellfish, yeast, or plants, or obtained by chemical synthesis.
해초 추출물로는 화장품에 배합 가능한 것이라면 어떠한 것이라도 되지만, 바람직하게는 갈조 엑기스, 홍조 엑기스, 녹조 엑기스 등을 들 수 있으며, 또, 이들의 해초 엑기스로부터 정제된 칼라기난, 아르긴산, 아르긴산나트륨, 아르긴산칼륨 등도 본 발명에서 사용되는 해초 엑기스에 포함된다. 해초 엑기스는 해초로부터 통상의 방법에 의해 정제하여 취득할 수 있다.The seaweed extract may be any one that can be blended into cosmetics, but preferably includes brown algae extract, red algae extract, green algae extract, etc. Also, calrageenan, arginic acid, sodium alginate, etc. purified from these seaweed extracts. Potassium arginate and the like are also included in the seaweed extract used in the present invention. Seaweed extract can be obtained by purifying seaweed by a conventional method.
본 발명의 화장료에는 상기 필수 성분과 더불어 필요에 따라 통상 화장료에 배합되는 다른 성분을 배합해도 된다. 이외에 첨가해도 되는 배합 성분으로서는 유지성분, 보습제, 에몰리엔트제, 계면 활성제, 유기 및 무기안료, 유기 분체, 자외선 흡수제, 방부제, 살균제, 산화 방지제, 식물 추출물, pH 조정제, 알콜, 색소, 향료, 혈행 촉진제, 냉감제, 제한(制汗)제, 정제수 등을 들 수 있다. 유지 성분으로서는 에스테르계 유지, 탄화수소계 유지, 실리콘계 유지, 불소계 유지, 동물 유지, 식물 유지 등을 들 수 있다.In addition to the above-mentioned essential ingredients, the cosmetic of the present invention may contain other ingredients usually blended in cosmetics as needed. Other ingredients that may be added include oils and fats, moisturizers, emollients, surfactants, organic and inorganic pigments, organic powders, ultraviolet absorbers, preservatives, disinfectants, antioxidants, plant extracts, pH adjusters, alcohol, colorants, fragrances, Examples include blood circulation promoters, cooling agents, antiperspirants, and purified water. Examples of oil and fat components include ester-based fats and oils, hydrocarbon-based fats and oils, silicone-based fats and oils, fluorine-based fats and oils, animal fats and oils, and vegetable fats and oils.
에스테르계 유지로서는 트리2-에틸헥산산글리세릴, 2-에틸헥산산세틸, 미리스틴산이소프로필, 미리스틴산 부틸, 팔미틴산이소프로필, 스테아르산에틸, 팔미틴산옥틸, 이소스테아르산이소세틸, 스테아르산부틸, 리놀레산 에틸,리놀레산이소프로필, 올레인산에틸, 미리스틴산이소세틸, 미리스틴산이소스테아릴, 팔미틴산이소스테아릴, 미리스틴산옥틸도데실, 이소스테아르산이소세틸, 세바신산디에틸, 아디핀산디이소프로필, 네오펜탄산이소알킬, 트리(카프릴, 카프린산)글리세릴, 트리2-에틸헥산산트리메틸롤프로판, 트리이소스테아르산 트리메틸롤프로판, 테트라2-에틸헥산산펜타엘리슬리톨, 카프릴산세틸, 라우린산데실, 라우린산헥실, 미리스틴산데실, 미리스틴산미리스틸, 미리스틴산세틸, 스테아르산스테아릴, 올레인산데실, 리시노올레인산세틸, 라우린산이소스테아릴, 미리스틴산이소트리데실, 팔미틴산이소세틸, 스테아르산옥틸, 스테아르산 이소세틸, 올레인산이소데실, 올레인산옥틸도데실, 리놀레산옥틸도데실, 이소스테아르산이소프로필, 2-에틸헥산산세토스테아릴, 2-에틸헥산산스테아릴, 이소스테아르산헥실, 디옥탄산에틸렌글리콜, 디올레인산에틸렌글리콜, 디카프린산프로필렌글리콜, 디(카프릴, 카프린산)프로필렌글리콜, 디카프릴산프로필렌글리콜, 디카프린산네오펜 틸글리콜, 디옥탄산네오펜틸글리콜, 트리카프릴산글리세릴, 트리운데실산글리세릴, 트리이소팔미틴산글리세릴, 트리이소스테아르산글리세릴, 네오펜탄산옥틸도데실, 옥탄산이소스테아릴, 이소노난산옥틸, 네오데칸산헥실데실, 네오데칸산옥틸도데실, 이소스테아르산이소세틸, 이소스테아르산이소스테아릴, 이소스테아르산옥틸데실, 폴리글리세린올레인산에스테르, 폴리글리세린이소스테아르산에스테르, 시트르산트리이소세틸, 시트르산트리이소알킬, 시트르산트리이소옥틸, 락트산라우릴, 락트산미리스틸, 락트산세틸, 락트산옥틸데실, 시트르산트리에틸, 시트르산아세틸트리에틸, 시트르산아세틸트리부틸, 시트르산트리옥틸, 말산디이소스테아릴, 히드록시스테아르산 2-에틸헥실, 숙신산디2-에틸헥실, 아디핀산디이소부틸, 세바신산디이소프로필, 세바신산디옥틸, 스테아르산콜레스테릴, 이소스테아르산콜레스테릴, 히드록시스테아르산콜레스테릴, 올레인산콜레스테릴, 올레인 산디히드로콜레스테릴, 이소스테아르산피트스테릴, 올레인산피트스테릴, 12-스테알로일히드록시스테아르산이소세틸, 12-스테알로일히드록시스테아르산스테아릴, 12-스테알로일히드록시스테아르산이소스테아릴 등의 에스테르 계 등을 들 수 있다.Ester-based oils include glyceryl tri2-ethylhexanoate, cetyl 2-ethylhexanoate, isopropyl myristate, butyl myristate, isopropyl palmitate, ethyl stearate, octyl palmitate, isocetyl isostearate, and stearic acid. Butyl, ethyl linoleate, isopropyl linoleate, ethyl oleate, isocetyl myristate, isostearyl myristate, isostearyl palmitate, octyldodecyl myristate, isocetyl isostearate, diethyl sebacate, adipine. Diisopropyl acid, isoalkyl neopentanoate, tri(caprylic, capric acid)glyceryl, trimethylolpropane tri2-ethylhexanoate, trimethylolpropane triisostearate, pentaelislitol tetra2-ethylhexanoate , cetyl caprylate, decyl laurate, hexyl laurate, decyl myristate, myristyl myristate, cetyl myristate, stearyl stearate, decyl oleate, cetyl ricinooleate, isostear laurate. Reyl, isotridecyl myristate, isocetyl palmitate, octyl stearate, isocetyl stearate, isodecyl oleate, octyldodecyl oleate, octyldodecyl linoleate, isopropyl isostearate, cetoester 2-ethylhexanoate Aryl, 2-ethylhexanoate stearyl, hexyl isostearate, ethylene glycol dioctanate, ethylene glycol dioleate, propylene glycol dicapric acid, di(capryl, capric acid) propylene glycol, propylene glycol dicaprylate, dicapric acid Neopentyl glycol prinate, neopentyl glycol dioctanate, glyceryl tricaprylate, glyceryl triundecylate, glyceryl triisopalmitate, glyceryl triisostearate, octyldodecyl neopentanoate, isostear octanoate. Reyl, octyl isononanoate, hexyldecyl neodecanoate, octyldodecyl neodecanoate, isocetyl isostearate, isostearyl isostearate, octyldecyl isostearate, polyglycerol oleic acid ester, polyglycerol isostearic acid ester. , Triisocetyl citrate, Triisoalkyl citrate, Triisooctyl citrate, Lauryl lactate, Myristyl lactate, Cetyl lactate, Octyldecyl lactate, Triethyl citrate, Acetyltriethyl citrate, Acetyltributyl citrate, Trioctyl citrate, Mal. Diisostearyl acid, 2-ethylhexyl hydroxystearate, di2-ethylhexyl succinate, diisobutyl adipate, diisopropyl sebacate, dioctyl sebacate, cholesteryl stearate, cholesteryl isostearate. , cholesteryl hydroxystearate, cholesteryl oleate, dihydrocholesteryl oleate, phytsteryl isostearate, phytsteryl oleate, 12-stealoyl hydroxystearate isocetyl, 12-stealoyl Ester systems such as stearyl monohydroxystearate and isostearyl 12-stealoylhydroxystearate can be mentioned.
탄화 수소계 유지로서는 스쿠알렌, 유동 파라핀, 알파-올레핀올리고머, 이소파라핀, 세레신, 파라핀, 유동 이소파라핀, 폴리부덴, 마이크로크리스탈린왁스, 와셀린 등의 탄화수소계 유지 등을 들 수 있다.Hydrocarbon-based fats and oils include squalene, liquid paraffin, alpha-olefin oligomer, isoparaffin, ceresin, paraffin, liquid isoparaffin, polybudene, microcrystalline wax, and petroleum jelly.
실리콘계 유지로서는 폴리메틸실리콘, 메틸페닐실리콘, 메틸시클로폴리실록산, 옥타메틸폴리실록산, 데카메틸폴리실록산, 도데카메틸시클로실록산, 디메틸실록산 및 메틸세틸옥시실록산 공중합체, 디메틸실록산 및 메틸스테알록시실록산 공중합체, 알킬 변성 실리콘유, 아미노 변성 실리콘유 등을 들 수 있다.Silicone oils include polymethyl silicone, methylphenyl silicone, methylcyclopolysiloxane, octamethylpolysiloxane, decamethylpolysiloxane, dodecamethylcyclosiloxane, dimethylsiloxane and methylcetyloxysiloxane copolymer, dimethylsiloxane and methylstealoxysiloxane copolymer, and alkyl. Modified silicone oil, amino-modified silicone oil, etc. can be mentioned.
불소계 유지로서는 퍼플루오로폴리에테르 등을 들 수 있다.Examples of fluorine-based fats and oils include perfluoropolyether.
동물 또는 식물 유지로서는 아보카도유, 아르몬드유, 올리브유, 참깨유, 쌀겨유, 새플라워유, 대두유, 옥수수유, 유채유, 행인(杏仁)유, 팜핵유, 팜유, 피마자유, 해바라기유, 포도종자유, 면실유, 야자유, 쿠쿠이너트유, 소맥배아유, 쌀 배아유, 시아버터, 월견초유, 마커데이미아너트유, 메도홈유, 난황유, 우지(牛脂), 마유, 밍크유, 오렌지라피유, 호호바유, 캔데리러왁스, 카르나바왁스, 액상 라놀린, 경화피마자유 등의 동물 또는 식물 유지를 들 수 있다.Animal or plant oils include avocado oil, almond oil, olive oil, sesame oil, rice bran oil, birdflower oil, soybean oil, corn oil, rapeseed oil, apricot oil, palm kernel oil, palm oil, castor oil, sunflower oil, and grape seed oil. , cottonseed oil, palm oil, cucumber nut oil, wheat germ oil, rice germ oil, shea butter, walnut colostrum oil, marker damia nut oil, meadow oil, egg yolk oil, beef tallow, horse oil, mink oil, orange rape oil, jojoba oil. , animal or plant oils such as candelier wax, carnaba wax, liquid lanolin, and hydrogenated castor oil.
보습제로서는 수용성 저분자 보습제, 지용성 분자 보습제, 수용성 고분자, 지용성 고분자 등을 들 수 있다.Moisturizers include water-soluble low-molecular-weight moisturizers, oil-soluble molecular moisturizers, water-soluble polymers, and fat-soluble polymers.
수용성 저분자 보습제로서는 세린, 글루타민, 솔비톨, 만니톨, 피롤리돈-카르복실산나트륨, 글리세린, 프로필렌글리콜, 1,3-부틸렌글리콜, 에틸렌글리콜, 폴리에틸렌글리콜B(중합도 n = 2 이상), 폴리프로필렌글리콜 (중합도 n = 2 이상), 폴리글리세린B(중합도 n = 2 이상), 락트산, 락트산염 등을 들 수 있다.Water-soluble low-molecular-weight moisturizers include serine, glutamine, sorbitol, mannitol, sodium pyrrolidone-carboxylate, glycerin, propylene glycol, 1,3-butylene glycol, ethylene glycol, polyethylene glycol B (degree of polymerization n = 2 or more), and polypropylene. Examples include glycol (degree of polymerization n = 2 or more), polyglycerin B (degree of polymerization n = 2 or more), lactic acid, lactate, etc.
지용성 저분자 보습제로서는 콜레스테롤, 콜레스테롤에스테르 등을 들 수 있다.Examples of fat-soluble low-molecular-weight moisturizers include cholesterol and cholesterol esters.
수용성 고분자로서는 카르복시비닐폴리머, 폴리아스파라긴산염, 트라가칸트, 크산탄검, 메틸셀룰로오스, 히드록시메틸셀룰로오스, 히드록시에틸셀룰로오스, 히드록시프로필셀룰로오스, 카르복시메틸셀룰로오스, 수용성키틴, 키토산, 덱스트린 등을 들 수 있다.Water-soluble polymers include carboxyvinyl polymer, polyaspartate, tragacanth, xanthan gum, methylcellulose, hydroxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, carboxymethylcellulose, water-soluble chitin, chitosan, dextrin, etc. You can.
지용성 고분자로서는 폴리비닐피롤리돈 및 에이코센 공중합체, 폴리비닐피롤리돈 및 헥사데센 공중합체, 니트로셀룰로오스, 덱스트린지방산에스테르, 고분자 실리콘 등을 들수 있다. 에몰리엔트제로서는 장쇄아실글루타민산 콜레스테릴에스테르, 히드록시스테아르산콜레스테릴, 12-히드록시스테아르산, 스테아르산, 로진산, 라놀린지방산콜레스테릴에스테르 등을 들 수 있다.Examples of oil-soluble polymers include polyvinylpyrrolidone and eicosene copolymers, polyvinylpyrrolidone and hexadecene copolymers, nitrocellulose, dextrin fatty acid ester, and polymer silicone. Examples of emollients include long-chain acyl glutamic acid cholesteryl ester, hydroxystearic acid cholesteryl, 12-hydroxystearic acid, stearic acid, rosin acid, and lanolin fatty acid cholesteryl ester.
계면 활성제로서는 비이온성 계면 활성제, 음이온성 계면 활성제, 양이온성 계면 활성제, 양성 계면 활성제 등을 들 수 있다.Examples of surfactants include nonionic surfactants, anionic surfactants, cationic surfactants, and amphoteric surfactants.
비이온성 계면 활성제로서는 자기 유화형 모노스테아르산글리세린, 프로필렌글리콜지방산에스테르, 글리세린 지방산에스테르, 폴리글리세린지방산에스테르, 솔비탄지방산에스테르, POE(폴리옥시에틸렌)솔비탄지방산에스테르, POE 솔비트지방산에스테르, POE 글리세린지방산에스테르, POE 알킬에테르, POE 지방산에스테르, POE 경화피마자유, POE 피마자유, POE 및 POP (폴리옥시에틸렌 및 폴리옥시프로필렌) 공중합체, POE 및 POP 알킬에테르, 폴리에테르변성실리콘, 라우린산알카놀아미드, 알킬아민옥시드, 수소첨가대두인지질 등을 들 수 있다.Nonionic surfactants include self-emulsifying glycerin monostearate, propylene glycol fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, sorbitan fatty acid ester, POE (polyoxyethylene) sorbitan fatty acid ester, POE sorbitan fatty acid ester, POE. Glycerin fatty acid ester, POE alkyl ether, POE fatty acid ester, POE hydrogenated castor oil, POE castor oil, POE and POP (polyoxyethylene and polyoxypropylene) copolymer, POE and POP alkyl ether, polyether modified silicone, lauric acid. Examples include alkanolamide, alkylamine oxide, and hydrogenated soybean phospholipid.
음이온성 계면 활성제로서는 지방산비누, 알파-아실술폰산염, 알킬술폰산염, 알킬알릴술폰산염, 알킬나프탈렌술폰산염, 알킬황산염, POE 알킬에테르황산염, 알킬아미드황산염, 알킬인산염, POE 알킬인산업, 알킬아미드 인산염, 알킬로일알킬타우린염, N-아실아미노산염, POE 알킬에테르카르복실산염, 알킬술포숙신산염, 알킬술포아세트산나트륨, 아실화 가수분해 콜라겐펩티드염, 퍼플루오로알킬인산에스테르 등을 들 수 있다.Anionic surfactants include fatty acid soap, alpha-acyl sulfonate, alkyl sulfonate, alkyl allyl sulfonate, alkyl naphthalene sulfonate, alkyl sulfate, POE alkyl ether sulfate, alkyl amide sulfate, alkyl phosphate, POE alkyl phosphate industry, alkyl amide. Phosphate, alkyloyl alkyl taurine salt, N-acylamino acid salt, POE alkyl ether carboxylate, alkyl sulfosuccinate, sodium alkyl sulfoacetate, acylated hydrolyzed collagen peptide salt, perfluoroalkyl phosphate ester, etc. there is.
양이온성 계면 활성제로서는 염화알킬트리메틸암모늄, 염화스테아릴트리메틸암모늄, 브롬화스테아릴트리메틸암모늄, 염화세토스테아릴트리메틸암모늄, 염화디스테아릴디메틸암모늄, 염화스테아릴디메틸벤질암모늄, 브롬화베헤닐트리메틸암모늄, 염화벤잘코늄, 스테아르산 디에틸아미노에틸아미드, 스테아르산디메틸아미노프로필아 미드, 라놀린 유도체 제 4급 암모늄염 등을 들 수 있다. 양성 계면 활성제로서는 카르복시베타인형, 아미드베타인형, 술포베타인형, 히드록시술포베타인형, 아미드 술포 베타인형, 포스포베타인형, 아미노카르복실산염형, 이미다졸린 유도체형, 아미드아민형 등의 양성 계면 활성제 등을 들 수 있다.Cationic surfactants include alkyltrimethylammonium chloride, stearyltrimethylammonium chloride, stearyltrimethylammonium bromide, cetostearyltrimethylammonium chloride, distearyldimethylammonium chloride, stearyldimethylbenzylammonium chloride, behenyltrimethylammonium bromide, and cationic surfactant. Examples include benzalkonium, diethylaminoethylamide stearate, dimethylaminopropyl stearate, and quaternary ammonium salts of lanolin derivatives. Amphoteric surfactants include carboxy beta type, amide beta type, sulfo beta type, hydroxy sulfo beta type, amide sulfo betaine type, phosphobetain type, aminocarboxylate type, imidazoline derivative type, and amidamine type. Amphoteric surfactants, etc. can be mentioned.
유기 및 무기 안료로서는 규산, 무수규산, 규산마그네슘, 탤크, 세리사이트, 마이카, 카올린, 벵갈라, 클레이, 벤토나이트, 티탄피막운모, 옥시염화비스무트, 산화지르코늄, 산화마그네슘, 산화아연, 산화티탄, 산화알루미늄, 황산칼슘, 황산바륨, 황산마그네슘, 탄산칼슘, 탄산마그네슘, 산화철, 군청, 산화크롬, 수산화크롬, 칼라민 및 이들의 복합체등의 무기 안료; 폴리아미드, 폴리에스테르, 폴리프로필렌, 폴리스티렌, 폴리우레탄, 비닐수지, 요소수지, 페놀수지, 불소수지, 규소수지, 아크릴수지, 멜라민수지, 에폭시수지, 폴리카보네이트 수지,디비닐벤젠 및 스티렌 공중합체, 실크파우더, 셀룰로오스, CI 피그먼트옐로우, CI 피그먼트오렌지 등의 유기 안료 및 이들의 무기 안료와 유기 안료의 복합 안료 등을 들 수 있다.Organic and inorganic pigments include silicic acid, anhydrous silicic acid, magnesium silicate, talc, sericite, mica, kaolin, bengala, clay, bentonite, titanium-coated mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide, titanium oxide, and aluminum oxide. Inorganic pigments such as calcium sulfate, barium sulfate, magnesium sulfate, calcium carbonate, magnesium carbonate, iron oxide, ultramarine blue, chromium oxide, chromium hydroxide, calamine and complexes thereof; Polyamide, polyester, polypropylene, polystyrene, polyurethane, vinyl resin, urea resin, phenol resin, fluorine resin, silicon resin, acrylic resin, melamine resin, epoxy resin, polycarbonate resin, divinylbenzene and styrene copolymer, Examples include organic pigments such as silk powder, cellulose, CI pigment yellow, and CI pigment orange, and complex pigments of these inorganic pigments and organic pigments.
유기 분체로서는 스테아르산칼슘 등의 금속비누; 세틸린산아연나트륨, 라우릴린산아연, 라우릴린산칼슘 등의 알킬인산금속염 ; N-라우로일-베타-알라닌칼슘, N-라우로일-베타-알라닌아연, N-라우로일글리신칼슘 등의 아실아미노산 다가금속염 ; N-라우로일-타우린칼슘, N-팔미토일-타우린칼슘 등의 아미드술폰산 다가금속염 ; N-엡실론-라우로일-L-리진, N-엡실론-팔미토일리진, N-알파-파리토일올니틴, N-알파-라우로일아르기닌, N-알파-경화우지지방산아실아르기닌 등의 N-아실염기성아미노산 ; N-라우로일글리실글리신 등의 N-아실폴리펩티드 ; 알파-아미노카프릴산, 알파-아미노라우린산 등의 알파-아미노지방산 ; 폴리에틸렌, 폴리프로필렌, 나일론, 폴리메틸메타크릴레이트, 폴리스티렌, 디비닐벤젠 및 스티렌 공중합체, 사불화에틸렌 등을 들 수 있다.Examples of organic powder include metal soap such as calcium stearate; Alkyl phosphate metal salts such as sodium zinc cetilate, zinc laurylate, and calcium laurylate; Acyl amino acid polyvalent metal salts such as N-lauroyl-beta-alanine calcium, N-lauroyl-beta-alanine zinc, and N-lauroyl glycine calcium; Amidesulfonic acid polyvalent metal salts such as N-lauroyl-taurine calcium and N-palmitoyl-taurine calcium; N such as N-epsilon-lauroyl-L-lysine, N-epsilon-palmitoylizine, N-alpha-paritoylolnithine, N-alpha-lauroylarginine, N-alpha-hydrogenated beef tallow fatty acid acylarginine, etc. -Acyl basic amino acid; N-acyl polypeptides such as N-lauroylglycylglycine; Alpha-amino fatty acids such as alpha-aminocaprylic acid and alpha-aminolauric acid; Examples include polyethylene, polypropylene, nylon, polymethyl methacrylate, polystyrene, divinylbenzene and styrene copolymers, and ethylene tetrafluoride.
자외선 흡수제로서는 파라아미노벤조산, 파라아미노벤조산에틸, 파라아미노벤조산아밀, 파라아미노벤조산옥틸, 살리실산에틸렌글리콜, 살리신산페닐, 살리신산옥틸, 살리신산벤질, 살리신산부틸페닐,살리신산호모멘틸, 계피산벤질, 파라메톡시계피산-2-에톡시에틸, 파라메톡시계피산옥틸, 디파라메톡시계피산모 노-2-에틸헥산글리세릴, 파라메톡시 계피산 이소프로필, 디이소프로필 및 디이소프로필계피산에스테르 혼합물, 우로카닌산, 우로카닌산에틸, 히드록시메톡시벤조페논, 히드록시메톡시벤조페논술폰산 및 그 염, 디히드록시메톡시벤조페논, 디히드록시메톡시벤조페논디술폰산나트륨, 디히드록시벤조페논, 테트라히드록시벤조페논, 4-tert-부틸-4'-메톡시디벤조일메탄, 2,4,6-트리아닐리노-p-(카르보-2'-에틸헥실-1'-옥시)-1,3,5-트리아진, 2-(2-히드록시-5-메틸페닐)벤조트리아졸 등을 들 수 있다.UV absorbers include para-aminobenzoic acid, ethyl para-aminobenzoate, amyl para-aminobenzoate, octyl para-aminobenzoate, ethylene glycol salicylate, phenyl salicylate, octyl salicylate, benzyl salicylate, butylphenyl salicylate, homomenthyl salicylate, and benzyl cinnamate. , paramethoxycinnamic acid-2-ethoxyethyl, octyl paramethoxycinnamic acid, mono-2-ethylhexane glyceryl diparamethoxycinnamic acid, isopropyl paramethoxycinnamic acid, diisopropyl and diisopropylcinnamic acid ester mixture, Urocanic acid, ethyl urocanic acid, hydroxymethoxybenzophenone, hydroxymethoxybenzophenone sulfonic acid and its salts, dihydroxymethoxybenzophenone, dihydroxymethoxybenzophenone disulfonate sodium, dihydroxybenzoate Phenone, tetrahydroxybenzophenone, 4-tert-butyl-4'-methoxydibenzoylmethane, 2,4,6-trianilino-p-(carbo-2'-ethylhexyl-1'-oxy)- 1,3,5-triazine, 2-(2-hydroxy-5-methylphenyl)benzotriazole, etc.
살균제로서는 히노키티올, 트리클로산, 트리클로로히드록시디페닐에테르, 크로르헥시딘글루콘산염, 페녹시에탄올, 레조르신, 이소프로필메틸페놀, 아줄렌, 살리칠산, 진크필리티온, 염화벤잘코늄, 감광소 301 호, 모노니트로과이어콜나트륨, 운데시렌산 등을 들 수 있다.Disinfectants include hinokitiol, triclosan, trichlorohydroxydiphenyl ether, chlorhexidine gluconate, phenoxyethanol, resorcin, isopropylmethylphenol, azulene, salicylic acid, zincphyllithione, benzalkonium chloride, and photosensitive. Sub-No. 301, mononitroguaiacol sodium, undecirenic acid, etc. can be mentioned.
산화 방지제로서는 부틸히드록시아니솔, 갈릭산프로필, 엘리소르빈산 등을 들 수 있다.Antioxidants include butylhydroxyanisole, propyl gallate, and elisorbic acid.
pH 조정제로서는 시트르산, 시트르산나트륨, 말산, 말산나트륨, 프말산, 프말산나트륨, 숙신산, 숙신산나트륨, 수산화나트륨, 인산일수소나트륨 등을 들 수 있다.Examples of pH adjusters include citric acid, sodium citrate, malic acid, sodium malate, fumal acid, sodium fumalate, succinic acid, sodium succinate, sodium hydroxide, and sodium monohydrogen phosphate.
알코올로서는 세틸알코올 등의 고급 알코올을 들 수 있다.Examples of alcohol include higher alcohols such as cetyl alcohol.
또한, 이외에 첨가해도 되는 배합 성분은 이에 한정되는 것은 아니며, 또, 상기 어느 성분도 본 발명의 목적 및 효과를 손상시키지 않는 범위 내에서 배합 가능하다.Additionally, the ingredients that may be added are not limited to this, and any of the above ingredients can be blended within the range that does not impair the purpose and effect of the present invention.
본 발명의 화장료는 용액, 유화물, 점성형 혼합물 등의 형상을 취할 수 있다.The cosmetic of the present invention may take the form of a solution, emulsion, viscous mixture, etc.
본 발명의 화장료 조성물에 포함되는 성분은 유효성분으로서 화장료 조성물에 통상적으로 이용되는 성분들을 포함할 수 있으며, 예를 들면, 안정화제, 용해화제, 비타민, 안료 및 향료와 같은 통상적인 보조제 및 담체를 포함한다.The ingredients included in the cosmetic composition of the present invention may include ingredients commonly used in cosmetic compositions as active ingredients, for example, conventional auxiliaries and carriers such as stabilizers, solubilizers, vitamins, pigments, and fragrances. Includes.
본 발명의 자초, 당귀, 감초, 백작약, 자소엽, 금은화, 연교, 유백피 및 황련 혼합 추출물을 유효성분으로 포함하는 항산화, 면역증강, 항염증, 항알러지, 항균, 여드름 개선 및 보습과 피부장벽 강화용 기능성 화장료 조성물은 당업계에서 통상적으로 제조되는 어떠한 제형으로도 제조될 수 있으며, 예를 들어 유액, 크림, 화장수, 팩, 파운데이션, 로션, 미용액, 모발화장료 등을 들 수 있다.Antioxidant, immune-enhancing, anti-inflammatory, anti-allergic, antibacterial, acne improvement, moisturizing, and skin barrier strengthening containing the mixed extract of the present invention of the present invention, including prickly pear, angelica root, licorice, white peony, perilla leaf, honeysuckle, perilla, milky bark, and yellow lotus mixed extract as active ingredients. Functional cosmetic compositions can be manufactured in any formulation commonly manufactured in the art, and examples include emulsions, creams, lotions, packs, foundations, lotions, beauty essences, hair cosmetics, etc.
구체적으로, 본 발명의 화장료 조성물은 스킨로션, 스킨소프너, 스킨토너, 밀크 로션, 아스트린젠트, 로션, 모이스쳐 로션, 영양로션, 맛사지크림, 영양크림, 모이스처크림, 핸드크림, 파운데이션, 에센스, 영양에센스, 팩, 비누, 클렌징폼, 클렌징로션, 클렌징크림, 헤어로션, 헤어토닉, 헤어에센스, 헤어샴푸, 헤어린스, 헤어트리트먼트, 바디로션 및 바디클린저의 제형을 포함한다.Specifically, the cosmetic composition of the present invention includes skin lotion, skin softener, skin toner, milk lotion, astringent, lotion, moisture lotion, nutritional lotion, massage cream, nutritional cream, moisture cream, hand cream, foundation, essence, nutritional essence, It includes formulations of packs, soaps, cleansing foams, cleansing lotions, cleansing creams, hair lotions, hair tonics, hair essences, hair shampoos, hair rinses, hair treatments, body lotions, and body cleansers.
본 발명의 제형이 페이스트, 크림 또는 겔인 경우에는 담체 성분으로서 동물섬유, 식물섬유, 왁스, 파라핀, 전분, 트라칸트, 셀룰로오스 유도체, 폴리에틸렌글리콜, 실리콘, 벤토나이트, 실리카, 탈크 또는 산화 아연 등이 이용될 수 있다.When the formulation of the present invention is a paste, cream or gel, animal fiber, plant fiber, wax, paraffin, starch, tracant, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide may be used as the carrier ingredient. You can.
본 발명의 제형이 파우더 또는 스프레이인 경우에는 담체 성분으로서 락토스, 탈크, 실리카, 알루미늄 히드록시드, 칼슘 실리케이트 또는 폴리아미드 파우더가 이용될 수 있고, 특히 스프레이인 경우에는 추가적으로 클로로플루오로히드로카본, 프로판/부탄 또는 디메틸 에테르와 같은 추진체를 포함할 수 있다.When the formulation of the present invention is a powder or spray, lactose, talc, silica, aluminum hydroxide, calcium silicate, or polyamide powder can be used as the carrier ingredient. In particular, when the formulation is a spray, chlorofluorohydrocarbon and propane may be used as carrier ingredients. /May contain propellants such as butane or dimethyl ether.
본 발명의 제형이 용액 또는 유탁액의 경우에는 담체 성분으로서 용매, 용매화제 또는 유탁화제가 이용되고, 예컨대 물, 에탄올, 이소프로판올, 에틸 카보네이트, 에틸 아세테이트, 벤질 알코올, 벤질 벤조에이트, 프로필렌글리콜, 1,3-부틸글리콜 오일, 글리세롤 지방족 에스테르, 폴리에틸렌 글리콜 또는 소르비탄의 지방산 에스테르가 있다.When the formulation of the present invention is a solution or emulsion, a solvent, solvating agent or emulsifying agent is used as a carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1 , 3-butyl glycol oil, glycerol aliphatic esters, polyethylene glycol or fatty acid esters of sorbitan.
본 발명의 제형이 현탁액인 경우에는 담체 성분으로서 물, 에탄올 또는 프로필렌 글리콜과 같은 액상 희석제, 에톡실화 이소스테아릴 알코올, 폴리옥시에틸렌 소르비톨 에스테르 및 폴리옥시에틸렌 소르비탄 에스테르와 같은 현탁제, 미소결정성 셀룰로오스, 알루미늄 메타히드록시드, 벤토나이트, 아가 또는 트라칸트 등이 이용될 수 있다.When the formulation of the present invention is a suspension, the carrier ingredients include water, a liquid diluent such as ethanol or propylene glycol, a suspending agent such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester, and polyoxyethylene sorbitan ester, and microcrystalline Cellulose, aluminum metahydroxide, bentonite, agar, or tracant may be used.
본 발명의 제형이 계면-활성제 함유 클린징인 경우에는 담체 성분으로서 지방족 알코올 설페이트, 지방족 알코올 에테르 설페이트, 설포숙신산 모노에스테르, 이세티오네이트, 이미다졸리늄 유도체, 메틸타우레이트, 사르코시네이트, 지방산 아미드 에테르 설페이트, 알킬아미도베타인, 지방족 알코올, 지방산 글리세리드, 지방산디에탄올아미드, 식물성 유, 리놀린 유도체 또는 에톡실화 글리세롤 지방산 에스테르 등이 이용될 수 있다.When the formulation of the present invention is a surfactant-containing cleansing agent, the carrier ingredients include aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, methyl taurate, sarcosinate, and fatty acid amide. Ether sulfate, alkylamidobetaine, fatty alcohol, fatty acid glyceride, fatty acid diethanolamide, vegetable oil, linoline derivative, or ethoxylated glycerol fatty acid ester can be used.
일 측면에서, 본 발명은 자초, 당귀, 감초, 백작약, 자소엽, 금은화, 연교, 유백피 및 황련 혼합 추출물을 유효성분으로 포함하는 항산화, 면역증강, 항염증, 항알러지, 항균, 여드름 개선 및 보습과 피부장벽 강화용 건강기능식품 조성물을 제공한다.In one aspect, the present invention provides anti-oxidation, immunity enhancement, anti-inflammatory, anti-allergy, antibacterial, acne improvement and Provides health functional food compositions for moisturizing and strengthening the skin barrier.
본 발명의 식품 조성물은 유효성분인 자초, 당귀, 감초, 백작약, 자소엽, 금은화, 연교, 유백피 및 황련을 함유하는 것 외에 통상의 식품 조성물과 같이 여러 가지 향미제 또는 천연 탄수화물 등을 추가 성분으로서 함유할 수 있다.The food composition of the present invention, in addition to containing the active ingredients such as Japanese herbacea, angelica root, licorice root, white peony, perilla leaves, honeysuckle, perilla, milky white bark and yellow lotus, contains additional ingredients such as various flavoring agents or natural carbohydrates like ordinary food compositions. It can be contained as.
상술한 천연 탄수화물의 예는 모노사카라이드, 예를 들어, 포도당, 과당 등; 디사카라이드, 예를 들어 말토스, 슈크로스 등; 및 폴리사카라이드, 예를 들어 덱스트린, 시클로덱스트린 등과 같은 통상적인 당, 및 자일리톨, 소르비톨, 에리트리톨 등의 당알콜이다. 상술한 향미제는 천연 향미제(타우마틴), 스테비아 추출물(예를 들어 레바우디오시드 A, 글리시르히진 등) 및 합성 향미제(사카린, 아스파르탐 등)를 유리하게 사용할 수 있다. 본 발명의 식품 조성물은 상기 약학적 조성물과 동일한 방식으로 제제화되어 기능성 식품으로 이용하거나, 각종 식품에 첨가할 수 있다. 본 발명의 조성물을 첨가할 수 있는 식품으로는 예를 들어, 음료류, 육류, 초코렛, 식품류, 과자류, 피자, 라면, 기타 면류, 껌류, 사탕류, 아이스크림류, 알코올 음료류, 비타민 복합제 및 건강보조식품류 등이 있다.Examples of the above-mentioned natural carbohydrates include monosaccharides such as glucose, fructose, etc.; Disaccharides such as maltose, sucrose, etc.; and polysaccharides, such as common sugars such as dextrin and cyclodextrin, and sugar alcohols such as xylitol, sorbitol, and erythritol. The above-described flavoring agents include natural flavoring agents (thaumatin), stevia extracts (e.g., rebaudioside A, glycyrrhizin, etc.), and synthetic flavoring agents (saccharin, aspartame, etc.). The food composition of the present invention can be formulated in the same way as the pharmaceutical composition and used as a functional food or added to various foods. Foods to which the composition of the present invention can be added include, for example, beverages, meat, chocolate, foods, confectionery, pizza, ramen, other noodles, gum, candy, ice cream, alcoholic beverages, vitamin complexes, health supplements, etc. There is.
또한 상기 식품 조성물은 유효성분인 추출물 외에 여러 가지 영양제, 비타민, 광물(전해질), 합성 풍미제 및 천연 풍미제 등의 풍미제, 착색제 및 중진제(치즈, 초콜릿 등), 펙트산 및 그의 염, 알긴산 및 그의 염, 유기산, 보호성 콜로이드 증점제, pH 조절제, 안정화제, 방부제, 글리세린, 알콜, 탄산음료에 사용되는 탄산화제 등을 함유할 수 있다. 그밖에 본 발명의 식품 조성물은 천연 과일 쥬스 및 과일 쥬스 음료 및 야채 음료의 제조를 위한 과육을 함유할 수 있다.In addition, the food composition contains, in addition to the extract as an active ingredient, various nutrients, vitamins, minerals (electrolytes), flavoring agents such as synthetic and natural flavors, colorants and thickening agents (cheese, chocolate, etc.), pectic acid and its salts, It may contain alginic acid and its salts, organic acids, protective colloidal thickeners, pH adjusters, stabilizers, preservatives, glycerin, alcohol, carbonating agents used in carbonated beverages, etc. In addition, the food composition of the present invention may contain pulp for the production of natural fruit juice, fruit juice beverages, and vegetable beverages.
본 발명의 건강기능식품 조성물은, 정제, 캅셀, 분말, 과립, 액상, 환 등의 형태로 제조 및 가공될 수 있다. 본 발명에서 "건강기능식품 조성물"이라 함은 건강기능식품에 관한 법률 제6727호에 따른 인체에 유용한 기능성을 가진 원료나 성분을 사용하여 제조 및 가공한 식품을 말하며, 인체의 구조 및 기능에 대하여 영양소를 조절하거나 생리학적 작용 등과 같은 보건용도에 유용한 효과를 얻을 목적으로 섭취하는 것을 의미한다. 본 발명의 건강기능식품은 통상의 식품 첨가물을 포함할 수 있으며, 식품 첨가물로서의 적합 여부는 다른 규정이 없는 한, 식품의약품안전청에 승인된 식품 첨가물 공전의 총칙 및 일반시험법 등에 따라 해당 품목에 관한 규격 및 기준에 의하여 판정한다. 상기 '식품 첨가물 공전'에 수재된 품목으로는 예를 들어, 케톤류, 글리신, 구연산칼슘, 니코틴산, 계피산 등의 화학적 합성물; 감색소, 감초추출물, 결정셀룰로오스, 고량색소, 구아검 등의 천연첨가물; L-글루타민산나트륨 제제, 면류첨가알칼리제, 보존료 제제, 타르색소제제 등의 혼합제제류 등을 들 수 있다. 예를 들어, 정제 형태의 건강기능식품은 본 발명의 유효성분을 부형제, 결합제, 붕해제 및 다른 첨가제와 혼합한 혼합물을 통상의 방법으로 과립화한 다음, 활택제 등을 넣어 압축성형하거나, 상기 혼합물을 직접 압축 성형할 수 있다. 또한 상기 정제 형태의 건강기능식품은 필요에 따라 교미제 등을 함유할 수도 있다. 캅셀 형태의 건강기능식품 중 경질 캅셀제는 통상의 경질 캅셀에 본 발명의 유효성분을 부형제 등의 첨가제와 혼합한 혼합물을 충진하여 제조할 수 있으며, 연질 캅셀제는 본 발명의 유효성분을 부형제 등의 첨가제와 혼합한 혼합물을 젤라틴과 같은 캅셀기제에 충진하여 제조할 수 있다. 상기 연질 캅셀제는 필요에 따라 글리세린 또는 소르비톨 등의 가소제, 착색제, 보존제 등을 함유할 수 있다. 환 형태의 건강기능식품은 본 발명의 유효성분과 부형제, 결합제, 붕해제 등을 혼합한 혼합물을 기존에 공지된 방법으로 성형하여 조제할 수 있으며, 필요에 따라 백당이나 다른 제피제로 제피할 수 있으며, 또는 전분, 탈크와 같은 물질로 표면을 코팅할 수도 있다. 과립 형태의 건강기능식품은 본 발명의 유효성분의 부형제, 결합제, 붕해제 등을 혼합한 혼합물을 기존에 공지된 방법으로 입상으로 제조할 수 있으며, 필요에 따라 착향제, 교미제 등을 함유할 수 있다.The health functional food composition of the present invention can be manufactured and processed in the form of tablets, capsules, powders, granules, liquids, pills, etc. In the present invention, “health functional food composition” refers to a food manufactured and processed using raw materials or ingredients with functionality useful to the human body pursuant to Act No. 6727 on Health Functional Foods, and refers to a food product that is related to the structure and function of the human body. It means taking it for the purpose of controlling nutrients or obtaining useful health effects such as physiological effects. The health functional food of the present invention may contain common food additives, and its suitability as a food additive is determined in accordance with the general provisions and general test methods of the food additive code approved by the Food and Drug Administration, unless otherwise specified. Judgment is made according to specifications and standards. Items listed in the 'Food Additive Code' include, for example, chemical compounds such as ketones, glycine, calcium citrate, nicotinic acid, and cinnamic acid; Natural additives such as dark pigment, licorice extract, crystalline cellulose, high-quality pigment, and guar gum; Examples include mixed preparations such as sodium L-glutamate preparations, noodle additive alkaline preparations, preservative preparations, and tar coloring preparations. For example, the health functional food in the form of a tablet is made by granulating a mixture of the active ingredient of the present invention with excipients, binders, disintegrants and other additives in a conventional manner, and then adding a lubricant and compression molding, or The mixture can be directly compression molded. In addition, the health functional food in the form of tablets may contain flavoring agents, etc., if necessary. Among capsule-type health functional foods, hard capsules can be manufactured by filling a regular hard capsule with a mixture of the active ingredient of the present invention mixed with additives such as excipients, and soft capsules can be prepared by mixing the active ingredient of the present invention with additives such as excipients. It can be manufactured by filling the mixture with a capsule base such as gelatin. The soft capsule may contain plasticizers such as glycerin or sorbitol, colorants, preservatives, etc., if necessary. The health functional food in the form of a pill can be prepared by molding a mixture of the active ingredient of the present invention and excipients, binders, disintegrants, etc., using a known method. If necessary, it can be coated with white sugar or other coating agent. Alternatively, the surface can be coated with substances such as starch or talc. Health functional food in the form of granules can be manufactured into granules by mixing a mixture of excipients, binders, disintegrants, etc. of the active ingredients of the present invention by a known method, and may contain flavoring agents, flavoring agents, etc., if necessary. You can.
일 측면에서, 본 발명은 자초, 당귀, 감초, 백작약, 자소엽, 금은화, 연교, 유백피 및 황련 혼합 추출물을 유효성분으로 포함하는 여드름 예방 또는 치료용 약학 조성물을 제공한다.In one aspect, the present invention provides a pharmaceutical composition for preventing or treating acne containing a mixed extract of chinensis, angelica root, licorice, white peony, perilla leaf, honeysuckle, perilla, milky white bark and yellow lotus mixed extract as active ingredients.
본 발명의 약학 조성물에는 유효성분 이외에 보조제(adjuvant)를 추가로 포함할 수 있다. 상기 보조제는 당해 기술분야에 알려진 것이라면 어느 것이나 제한 없이 사용할 수 있으나, 예를 들어 프로인트(Freund)의 완전 보조제 또는 불완전 보조제를 더 포함하여 그 면역성을 증가시킬 수 있다.The pharmaceutical composition of the present invention may further include adjuvants in addition to the active ingredients. Any adjuvant known in the art may be used without limitation, but, for example, Freund's complete adjuvant or incomplete adjuvant may be further included to increase immunity.
본 발명에 따른 약학 조성물은 유효성분을 약학적으로 허용된 담체에 혼입시킨 형태로 제조될 수 있다. 여기서, 약학적으로 허용된 담체는 제약 분야에서 통상 사용되는 담체, 부형제 및 희석제를 포함한다. 본 발명의 약학 조성물에 이용할 수 있는 약학적으로 허용된 담체는 이들로 제한되는 것은 아니지만, 락토스, 덱스트로스, 수크로스, 솔비톨, 만니톨, 자일리톨, 에리스리톨, 말티톨, 전분, 아카시아 고무, 알지네이트, 젤라틴, 칼슘 포스페이트, 칼슘 실리케이트, 셀룰로스, 메틸 셀룰로스, 폴리비닐 피롤리돈, 물, 메틸히드록시벤조에이트, 프로필히드록시벤조에이트, 탈크, 마그네슘 스테아레이트 및 광물유를 들 수 있다.The pharmaceutical composition according to the present invention can be prepared by incorporating the active ingredient into a pharmaceutically acceptable carrier. Here, pharmaceutically acceptable carriers include carriers, excipients, and diluents commonly used in the pharmaceutical field. Pharmaceutically acceptable carriers that can be used in the pharmaceutical composition of the present invention include, but are not limited to, lactose, dextrose, sucrose, sorbitol, mannitol, xylitol, erythritol, maltitol, starch, gum acacia, alginate, gelatin, Examples include calcium phosphate, calcium silicate, cellulose, methyl cellulose, polyvinyl pyrrolidone, water, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate and mineral oil.
본 발명의 약학 조성물은 각각 통상의 방법에 따라 산제, 과립제, 정제, 캡슐제, 현탁액, 에멀전, 시럽, 에어로졸 등의 경구형 제형, 외용제, 좌제 또는 멸균 주사용액의 형태로 제형화하여 사용될 수 있다.The pharmaceutical composition of the present invention can be formulated and used in the form of oral dosage forms such as powders, granules, tablets, capsules, suspensions, emulsions, syrups, aerosols, external preparations, suppositories, or sterile injection solutions according to conventional methods. .
제제화할 경우에는 통상 사용하는 충진제, 증량제, 결합제, 습윤제, 붕해제, 계면활성제 등의 희석제 또는 부형제를 사용하여 조제될 수 있다. 경구투여를 위한 고형제제에는 정제, 환제, 산제, 과립제, 캡슐제 등이 포함되며, 그러한 고형 제제는 유효성분에 적어도 하나 이상의 부형제, 예를 들면 전분, 칼슘 카르보네이트, 수크로스, 락토오스, 젤라틴 등을 섞어 조제될 수 있다. 또한, 단순한 부형제 이외에 마그네슘 스테아레이트, 탈크 같은 윤활제들도 사용될 수 있다. 경구투여를 위한 액상 제제로는 현탁제, 내용액제, 유제, 시럽제 등이 해당되는데, 일반적으로 사용되는 희석제인 물, 리퀴드 파라핀 이외에 여러 가지 부형제, 예를 들면 습윤제, 감미제, 방향제, 보존제 등이 포함될 수 있다. 비경구 투여를 위한 제제에는 멸균된 수용액, 비수용성용제, 현탁제, 유제, 동결건조 제제 및 좌제가 포함된다. 비수용성용제, 현탁제로는 프로필렌 글리콜, 폴리에틸렌 글리콜, 올리브유와 같은 식물성 기름, 에틸올레이트와 같은 주사 가능한 에스테르 등이 사용될 수 있다. 좌제의 기제로는 위텝솔(witepsol), 트윈(tween) 61, 카카오지, 라우린지, 글리세로젤라틴 등이 사용될 수 있다.When formulated, it can be prepared using diluents or excipients such as commonly used fillers, extenders, binders, wetting agents, disintegrants, and surfactants. Solid preparations for oral administration include tablets, pills, powders, granules, capsules, etc., and such solid preparations contain the active ingredient plus at least one excipient, such as starch, calcium carbonate, sucrose, lactose, and gelatin. It can be prepared by mixing etc. Additionally, in addition to simple excipients, lubricants such as magnesium stearate and talc can also be used. Liquid preparations for oral administration include suspensions, oral solutions, emulsions, and syrups. In addition to the commonly used diluents such as water and liquid paraffin, they contain various excipients such as wetting agents, sweeteners, fragrances, and preservatives. You can. Preparations for parenteral administration include sterile aqueous solutions, non-aqueous solutions, suspensions, emulsions, lyophilized preparations, and suppositories. Non-aqueous solvents and suspensions include propylene glycol, polyethylene glycol, vegetable oil such as olive oil, and injectable ester such as ethyl oleate. As a base for suppositories, witepsol, tween 61, cacao, laurel, glycerogelatin, etc. can be used.
본 발명에 따른 약학 조성물은 개체에 다양한 경로로 투여될 수 있다. 투여의 모든 방식이 예상될 수 있는데, 예를 들면 경구, 정맥, 근육, 피하, 복강내 주사에 의해 투여될 수 있다.The pharmaceutical composition according to the present invention can be administered to an individual through various routes. All modes of administration are contemplated, for example, by oral, intravenous, intramuscular, subcutaneous, or intraperitoneal injection.
본 발명에 따른 약학 조성물의 투여량은 개체의 연령, 체중, 성별, 신체 상태 등을 고려하여 선택된다. 상기 약학 조성물 중 포함되는 유효성분의 농도는 대상에 따라 다양하게 선택할 수 있음은 자명하며, 바람직하게는 약학 조성물에 0.01 ~ 5,000 ㎍/ml의 농도로 포함되는 것이다. 그 농도가 0.01 ㎍/ml 미만일 경우에는 약학 활성이 나타나지 않을 수 있고, 5,000 ㎍/ml를 초과할 경우에는 인체에 독성을 나타낼 수 있다.The dosage of the pharmaceutical composition according to the present invention is selected taking into account the age, weight, gender, physical condition, etc. of the individual. It is obvious that the concentration of the active ingredient included in the pharmaceutical composition can be selected in various ways depending on the target, and is preferably included in the pharmaceutical composition at a concentration of 0.01 to 5,000 μg/ml. If the concentration is less than 0.01 ㎍/ml, pharmaceutical activity may not appear, and if it exceeds 5,000 ㎍/ml, it may be toxic to the human body.
상기 약학 조성물은 다양한 경구 또는 비경구 투여 형태로 제형화될 수 있다.The pharmaceutical composition may be formulated into various oral or parenteral dosage forms.
경구 투여용 제형으로는 예를 들면 정제, 환제, 경질, 연질 캅셀제, 액제, 현탁제, 유화제, 시럽제, 과립제 등이 있는데, 이들 제형은 유효성분 이외에 희석제(예: 락토즈, 덱스트로즈, 수크로즈, 만니톨, 솔비톨, 셀룰로즈 및/또는 글리신), 활택제(예: 실리카, 탈크, 스테아르산 및 그의 마그네슘 또는 칼슘염 및/ 또는 폴리에틸렌 글리콜)를 추가로 포함할 수 있다. 또한, 상기 정제는 마그네슘 알루미늄 실리케이트, 전분 페이스트, 젤라틴, 트라가칸스, 메틸셀룰로즈, 나트륨 카복시메틸셀룰로즈 및/또는 폴리비닐피롤리딘과 같은 결합제를 함유할 수 있으며, 경우에 따라 전분, 한천, 알긴산 또는 그의 나트륨 염과 같은 붕해제 또는 비등 혼합물 및/또는 흡수제, 착색제, 향미제 및 감미제를 함유할 수 있다. 상기 제형은 통상적인 혼합, 과립화 또는 코팅 방법에 의해 제조될 수 있다.Dosage forms for oral administration include, for example, tablets, pills, hard and soft capsules, solutions, suspensions, emulsifiers, syrups, granules, etc. These dosage forms contain diluents (e.g. lactose, dextrose, water) in addition to the active ingredient. crose, mannitol, sorbitol, cellulose and/or glycine), lubricants (e.g. silica, talc, stearic acid and its magnesium or calcium salts and/or polyethylene glycol). Additionally, the tablets may contain binders such as magnesium aluminum silicate, starch paste, gelatin, tragacanth, methylcellulose, sodium carboxymethylcellulose and/or polyvinylpyrrolidine, and in some cases starch, agar, alginic acid. or disintegrants such as sodium salts thereof or effervescent mixtures and/or absorbents, colorants, flavoring and sweetening agents. The formulation can be prepared by conventional mixing, granulating or coating methods.
또한, 비경구 투여용 제형의 대표적인 것은 주사용 제제이며, 주사용 제제의 용매로서 물, 링거액, 등장성 생리식염수 또는 현탁액을 들 수 있다. 상기 주사용 제제의 멸균 고정 오일은 용매 또는 현탁 매질로서 사용할 수있으며 모노-, 디-글리세라이드를 포함하여 어떠한 무자극성 고정오일도 이러한 목적으로 사용될 수 있다.In addition, representative formulations for parenteral administration are injectable formulations, and solvents for injectable formulations include water, Ringer's solution, isotonic saline solution, or suspension. The sterile fixed oil of the injectable preparation can be used as a solvent or suspending medium, and any non-irritating fixed oil, including mono- and di-glycerides, can be used for this purpose.
또한, 상기 주사용 제제는 올레산과 같은 지방산을 사용할 수 있다.Additionally, the injectable preparation may use fatty acids such as oleic acid.
이하, 실시예를 통하여 본 발명을 보다 자세히 설명한다. 다만, 상기 실시예 및 실험예는 본 발명에 대한 예시로 제시되는 것으로, 당업자에게 주지 저명한 기술 또는 구성에 대한 구체적인 설명이 본 발명의 요지를 불필요하게 흐릴 수 있다고 판단되는 경우에는 그 상세한 설명을 생략할 수 있고, 이에 의해 본 발명이 제한되지는 않는다. 본 발명은 후술하는 특허청구범위의 기재 및 그로부터 해석되는 균등 범주 내에서 다양한 변형 및 응용이 가능하다.Hereinafter, the present invention will be described in more detail through examples. However, the above examples and experimental examples are presented as examples of the present invention, and if a detailed description of a technique or configuration well known to those skilled in the art is judged to unnecessarily obscure the gist of the present invention, the detailed description is omitted. It can be done, and the present invention is not limited thereby. The present invention is capable of various modifications and applications within the description of the claims described below and the scope of equivalents interpreted therefrom.
<준비예 1> 시료의 제조<Preparation Example 1> Preparation of sample
상기 국내산 한약재들은 세모산3399 (경기 평택시 팽성읍 팽성북로 417)에서 구입하여 사용하였다. 구입한 한약재들은 2~3회 세척하여 건조하였다. 한방원료를 추출하기 위해 자초, 당귀, 감초, 백작약, 자소엽, 금은화, 연교, 유백피, 황련을 서로 배합하여 유용성 성분인 포도씨오일에 침적한다. 이후, 200 내지 300 ℃로 가열 유지하면서 35분간 교반한후에 100 ℃까지 냉각하여, 200 mesh 여과망에 여과된 여과물을 냉장보관 하였다.The domestic herbal medicines were purchased and used at Semosan 3399 (417 Paengseongbuk-ro, Paengseong-eup, Pyeongtaek-si, Gyeonggi-do). The purchased herbal medicines were washed 2-3 times and dried. In order to extract oriental medicinal ingredients, weeds, angelica root, licorice root, white peony, perilla leaf, honeysuckle, lotus root, milky white bark, and yellow lotus are mixed together and soaked in grape seed oil, which is an oil-soluble ingredient. Afterwards, the mixture was stirred for 35 minutes while maintaining heating at 200 to 300°C, then cooled to 100°C, and the filtrate filtered through a 200 mesh filter was stored in the refrigerator.
<준비예 2> 시약 및 재료<Preparation Example 2> Reagents and materials
본 실험에 사용한 Dulbecco’s modified Eagle’s medium (DMEM)과 phosphate buffer saline (PBS)는 Welgene Inc. (Daegu, Korea)에서, fetal bovine serum (FBS)과 penicillin/streptomycin은 각각 GenDEPOT (Katy, TX, USA)과 Gibco (Grand Island, NY, USA)에서 구입하여 사용하였다. Dimethylsulfoxide (DMSO), ursolic acid, elastase, N-succinyl-tri-alanyl-p-nitroanilide (STANA), 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenylte -trazolium bromide (MTT)는 Sigma-Aldrich (St. Louis, MO, USA)에서 구입하여 사용하였다. 그 외 언급하지 않은 시약들은 모두 Sigma-Aldrich (St. Louis, MO, USA)에서 구입하여 사용하였다. Dulbecco’s modified Eagle’s medium (DMEM) and phosphate buffer saline (PBS) used in this experiment were purchased from Welgene Inc. (Daegu, Korea), fetal bovine serum (FBS) and penicillin/streptomycin were purchased from GenDEPOT (Katy, TX, USA) and Gibco (Grand Island, NY, USA), respectively. Dimethylsulfoxide (DMSO), ursolic acid, elastase, N-succinyl-tri-alanyl-p-nitroanilide (STANA), 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenylte-trazolium bromide (MTT) was purchased and used from Sigma-Aldrich (St. Louis, MO, USA). All other reagents not mentioned were purchased from Sigma-Aldrich (St. Louis, MO, USA).
[실험방법][Experimental method]
1. 독성평가 : 세포 생존율 측정 (MTT assay)1. Toxicity evaluation: Measurement of cell viability (MTT assay)
본 발명의 혼합 추출물 TB2 시료의 세포 독성을 각질형성세포 HaCaT, 대식세포 RAW264.7 및 비만세포주 RBL-2H3에서 각각 확인하였다. 구체적으로, HaCaT, RAW264.7 및 RBL-2H3 세포주를 배양접시의 바닥에 접종한 후 페니실린 (100 IU/ml), 스트렙토마이신 (100 μg/ml), 10 % FBS (fetal bovine serum)를 함유하는 DMEM (Dulbecco' Modifide Eagle' Medium) 배지를 넣고 37 ℃를 유지하여 5 % 이산화탄소 배양기에서 배양하였다. 각 세포는 96-웰 플레이트에 1×104 cells/well의 세포수를 부착한 후, 각 well에 농도별로 TB2 시료를 첨가한 후 24시간 후 MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) 시약(5 mg/ml)을 넣고, 4시간 동안 반응한 후 상등액을 제거하였다. 각 well에 형성된 formazan은 DMSO 200 μl를 첨가하여 녹이고, Epoch Microplate Spectrophotometer (BioTek, Winooski Vermont, USA)를 이용하여 540 nm에서 흡광도를 측정하였다. 세포 생존율은 대조군과 비교하여 흡광도의 백분율로 나타내었다. 결과를 도 1에 나타내었다.The cytotoxicity of the mixed extract TB2 sample of the present invention was confirmed in keratinocyte HaCaT, macrophage RAW264.7, and mast cell line RBL-2H3, respectively. Specifically, HaCaT, RAW264.7, and RBL-2H3 cell lines were inoculated on the bottom of a culture dish and then added to the culture dish containing penicillin (100 IU/ml), streptomycin (100 μg/ml), and 10% FBS (fetal bovine serum). DMEM (Dulbecco' Modifide Eagle' Medium) medium was added and the culture was maintained at 37°C in a 5% carbon dioxide incubator. Each cell was attached to a 96 -well plate at a cell number of 1 yl)-2,5-diphenyltetrazolium bromide) reagent (5 mg/ml) was added, reacted for 4 hours, and then the supernatant was removed. The formazan formed in each well was dissolved by adding 200 μl of DMSO, and the absorbance was measured at 540 nm using an Epoch Microplate Spectrophotometer (BioTek, Winooski Vermont, USA). Cell viability was expressed as a percentage of absorbance compared to control. The results are shown in Figure 1.
2. 항산화 효과 : DPPH 라디칼 소거능 측정2. Antioxidant effect: Measurement of DPPH radical scavenging ability
DPPH 라디칼 소거능은 시료의 free radical 소거 능력이나 수소 공여능력을 평가하는 방법으로 다양한 천연소재로부터 항산화 능력을 알아 보기 위한 측정법으로 가장 쉽고 널리 알려진 방법이다. 본 발명의 한약재 혼합 추출물 (TB2)의 항산화 효과를 측정하기 위하여 DPPH 라디칼 소거능을 측정하였다. 구체적으로, 96-웰 플레이트에 농도별로 DMSO를 이용하여 희석한 TB2 시료를 각각 100 μl를 넣고 99 % 에틸알코올 100 μl 및 99 % 에틸알코올로 희석한 0.4 mM DPPH (2,2-diphenyl-1-picrylhydrazyl) 용액 100 μl를 넣은 후 암실에서 30분 동안 반응시킨 후 517 ㎚에서 Molecular Devices microplate reader (PerkinElmer, USA)를 이용하여 흡광도를 측정하였으며, 하기의 수학식 1을 이용하여 그래프를 나타내었다. 결과를 도 2에 나타내었다.DPPH radical scavenging ability is a method of evaluating the free radical scavenging ability or hydrogen donating ability of a sample and is the easiest and most widely known measurement method to determine the antioxidant ability of various natural materials. To measure the antioxidant effect of the herbal medicine mixed extract (TB2) of the present invention, the DPPH radical scavenging ability was measured. Specifically, 100 μl of each TB2 sample diluted with DMSO for each concentration was added to a 96-well plate, followed by 100 μl of 99% ethyl alcohol and 0.4 mM DPPH (2,2-diphenyl-1-) diluted with 99% ethyl alcohol. After adding 100 μl of picrylhydrazyl) solution and reacting in the dark for 30 minutes, the absorbance was measured at 517 nm using a Molecular Devices microplate reader (PerkinElmer, USA), and a graph was shown using Equation 1 below. The results are shown in Figure 2.
[수학식 1][Equation 1]
DPPH radical 소거활성 (%) = (1-대조군 흡광도/실험군 흡광도) × 100DPPH radical scavenging activity (%) = (1-control group absorbance/experimental group absorbance) × 100
3. 면역증강 효과 : Nitirc oxide 분비량 측정3. Immune-enhancing effect: Measurement of nitirc oxide secretion amount
인체 적응면역이 작동하기 전에 외부자극에 대해 신속하게 대응할 수 있는 선천성 면역기능을 담당하는 대식세포는 다양한 활성인자를 분비하여 면역을 증강하여 외부자극으로부터 보호한다. 병원체 침입 등의 외부자극에 대해 활성화된 대식세포가 분비하는 nitric oxide (NO)는 혈관이완, 신경전달, 혈소판 응집억제, 평활근이완, 암세포 독성작용 등의 면역증강 및 면역조절인자로 알려져 있다.Macrophages, which are responsible for the innate immune function that can quickly respond to external stimuli before the body's adaptive immunity operates, secrete various activating factors to strengthen immunity and protect against external stimuli. Nitric oxide (NO), which is secreted by macrophages activated in response to external stimuli such as invading pathogens, is known to be an immune-enhancing and immune-regulating factor, such as vascular relaxation, nerve transmission, inhibition of platelet aggregation, smooth muscle relaxation, and cancer cell toxicity.
본 발명에 따른 한약재 혼합 추출물 (TB2)의 면역증강 효과를 확인하기 위해 대식세포주 RAW264.7을 이용하였다. 구체적으로 RAW264.7 세포를 96-웰 플레이트에 2×104 cells/well로 분주하고 세포가 부착되면 TB2 시료를 농도별로 처리한 후, 18시간 더 배양하였다. 배양 후 상층액 100 μl를 수득하여 Griess reagent (1% sulfonamide, N-(1-naphthyl)-ethylene-diamine dihydrochloride in 2.5 % phosphoric acid solution)를 넣고 10분간 실온에서 반응시킨 후 550 ㎚에서 흡광도를 측정하였다. 세포 상층액으로 분비된 nitir coxide의 농도는 sodium nitrite (NaNO2)의 표준곡선과 비교하여 산출하였다. 결과를 도 3에 나타내었다.To confirm the immune enhancing effect of the herbal medicine mixed extract (TB2) according to the present invention, the macrophage cell line RAW264.7 was used. Specifically, RAW264.7 cells were distributed at 2×10 4 cells/well in a 96-well plate, and when the cells attached, TB2 samples were treated at different concentrations and cultured for an additional 18 hours. After incubation, obtain 100 μl of the supernatant, add Griess reagent (1% sulfonamide, N-(1-naphthyl)-ethylene-diamine dihydrochloride in 2.5 % phosphoric acid solution), react at room temperature for 10 minutes, and measure absorbance at 550 nm. did. The concentration of nitir coxide secreted into the cell supernatant was calculated by comparing it with the standard curve of sodium nitrite (NaNO 2 ). The results are shown in Figure 3.
4. 항염증 효과 : qRT-PCR 방법으로 mRNA 발현측정4. Anti-inflammatory effect: Measurement of mRNA expression using qRT-PCR method
본 발명에 따른 한약재 혼합 추출물 (TB2)의 염증 억제 효과를 확인하기 위해 염증관련 대식세포주를 이용하여 LPS (lipopolysaccharide)로 염증환경을 유도하였다. 이때, TB2 시료를 첨가하여 LPS 자극으로 증가된 COX-2 (cyclooxygenase-2), Tumor Necrosis Factor-α human (TNF-α), Inducible nitric oxide synthase (iNOS) 염증유발인자의 mRNA 발현 억제 효과를 확인하였다. 구체적으로 RAW264.7 세포를 6-웰 플레이트에 2×104 cells/well로 분주하고 세포가 부착되면 TB2 시료를 농도별로 Lipopolysaccharides (LPS) 1 μg/ml와 함께 처리하여, 18시간 더 배양하였다. 양성대조군으로는 Celecoxib (5 μM)와 Dexmedetomidine (100 μM)를 처리하였다. 배양 후 TrizolTM (Ambion, Thermo, USA)로 total RNA를 추출하고 cDNA 합성 키트 (ECDNA100, NanoHelix, Daejeon, Korea)를 이용하여 cDNA를 합성하였다. 이후 프리미어 qPCR 키트 (PQL-S500, NanoHelix, Daejeon, Korea)를 사용하여 Real-Time PCR (polymerase chain reaction) (CFX Connect, Biorad) 기계로 하기 표 1의 프라이머 세트를 이용하여 mRNA 발현량을 측정하였으며, 결과를 도 4에 나타내었다.To confirm the anti-inflammatory effect of the herbal medicine mixed extract (TB2) according to the present invention, an inflammatory environment was induced with lipopolysaccharide (LPS) using an inflammation-related macrophage cell line. At this time, TB2 samples were added to confirm the effect of suppressing mRNA expression of inflammatory factors such as COX-2 (cyclooxygenase-2), Tumor Necrosis Factor-α human (TNF-α), and Inducible nitric oxide synthase (iNOS), which were increased by LPS stimulation. did. Specifically, RAW264.7 cells were distributed in a 6-well plate at 2×10 4 cells/well, and when the cells attached, the TB2 sample was treated with 1 μg/ml of Lipopolysaccharides (LPS) at each concentration and cultured for an additional 18 hours. As a positive control group, Celecoxib (5 μM) and Dexmedetomidine (100 μM) were treated. After culturing, total RNA was extracted with TrizolTM (Ambion, Thermo, USA), and cDNA was synthesized using a cDNA synthesis kit (ECDNA100, NanoHelix, Daejeon, Korea). Afterwards, the mRNA expression level was measured using the primer set in Table 1 below using a Real-Time PCR (polymerase chain reaction) (CFX Connect, Biorad) machine using a Premier qPCR kit (PQL-S500, NanoHelix, Daejeon, Korea). , the results are shown in Figure 4.
5. 항알러지 효과 : β-Hexosaminidase release assay 5. Anti-allergic effect: β-Hexosaminidase release assay
β-Hexosaminidase 분비는 천식이나 알러지 반응에 의해 비만세포나 호염구의 과립 안에 저장되어 있던 히스타민 (histamine)이 세포 밖으로 분비될 때 함께 분비되는 효소로 세포 탈과립 반응의 측정 지표로 많이 사용되고 있으며, 알러지 억제 물질을 탐색하고 생리활성을 측정하는데 유용하게 이용되고 있다. 본 발명에 따른 한약재 혼합 추출물 (TB2)의 항알러지 효과를 확인하기 위해 비만세포주인 RBL-2H3 세포를 이용하였다. 구체적으로, RBL-2H3 세포를 24-웰 플레이트에 5×105 cells/well 농도로 분주하였으며, 16시간 후 DNP-bovine serum albumin (DNP-BSA)-specific IgE로 37 °C에서 4시간 동안 반응시켰다. 활성화된 세포에 농도별로 TB2 시료를 처리하였으며, 30분 후 antigen (DNP-BSA)의 최종농도를 100 ng/ml로 처리하였다. 30분 후 ice에 10분간 보관하여 반응을 정지시켰으며, 상층액을 채취하여 4-Nitrophenyl N-acetyl-β-D-glucosaminide (substrate PNAG)를 같은 양으로 처리하고, 37 °C에서 1시간 동안 반응시켰다. 탈과립억제 평가는 histamine과 같이 분비되는 β-hexosaminidase의 양을 405 nm에서 측정하였으며, 대조군에 대한 처리군의 억제율(%)로 나타내었다. 양성대조군으로는 Ketotifen (KF; 50 μM)을 사용하였다. 결과를 도 5에 나타내었다.β-Hexosaminidase secretion is an enzyme secreted together when histamine stored in the granules of mast cells or basophils is secreted out of the cell due to asthma or allergic reactions. It is widely used as an indicator of cell degranulation reaction and is an allergy suppressant. It is usefully used to explore and measure physiological activity. To confirm the anti-allergy effect of the herbal medicine mixed extract (TB2) according to the present invention, RBL-2H3 cells, a mast cell line, were used. Specifically, RBL-2H3 cells were distributed in a 24-well plate at a concentration of 5 × 10 5 cells/well, and after 16 hours, reacted with DNP-bovine serum albumin (DNP-BSA)-specific IgE at 37 °C for 4 hours. I ordered it. The activated cells were treated with TB2 samples at different concentrations, and after 30 minutes, the final concentration of antigen (DNP-BSA) was treated at 100 ng/ml. After 30 minutes, the reaction was stopped by storing on ice for 10 minutes. The supernatant was collected, treated with the same amount of 4-Nitrophenyl N-acetyl-β-D-glucosaminide (substrate PNAG), and incubated at 37 °C for 1 hour. reacted. In the evaluation of degranulation inhibition, the amount of β-hexosaminidase secreted together with histamine was measured at 405 nm and expressed as the inhibition rate (%) of the treatment group relative to the control group. Ketotifen (KF; 50 μM) was used as a positive control. The results are shown in Figure 5.
6. 항균 효과 6. Antibacterial effect
6-1. 균 배양6-1. bacterial culture
본 연구에 사용된 균은 Escherichia coli (KCTC 2441), Staphylococcus aureus (KCTC 1621)은 미생물자원센터 (KCTC)에서 구입하여 사용하였으며, Propionibacterium acnes (KCCM 42791)는 한국미생물보존센터 (Korean Culture Center of Microorganisms, KCCM, Seoul, Korea)에서 분양받았다. 본 발명에 따른 TB2의 여드름균을 포함한 항균효과를 확인하기 위해 디스크확산법 (Disc diffusion assay)와 항균활성의 최소저해농도 (Minimum inhibitory concentration)를 측정하였다. 실험에 사용한 각 미생물 균주, 배지 및 배양조건은 하기 표 2에 정리하였다.The bacteria used in this study were Escherichia coli (KCTC 2441) and Staphylococcus aureus (KCTC 1621) purchased from the Microorganism Resource Center (KCTC), and Propionibacterium acnes (KCCM 42791) was purchased from the Korean Culture Center of Microorganisms. , KCCM, Seoul, Korea). To confirm the antibacterial effect of TB2 according to the present invention, including acne bacteria, disc diffusion assay and minimum inhibitory concentration of antibacterial activity were measured. Each microbial strain, medium, and culture conditions used in the experiment are summarized in Table 2 below.
6-2. 항균효과 확인 : 디스크확산법 (Disc diffusion assay)6-2. Confirmation of antibacterial effect: Disc diffusion assay
Paper disc에 의한 항균활성 측정은 disc diffusion assay로 측정 하였다. 순수 분리된 각 균을 취해 10 ml의 액체배지(Tryptic Soy Broth)에 접종하여 각각 균의 생육적온에서 24시간씩 3회 배양 후 항균활성 시험 균으로 사용하였다. 각각의 시험 균 농도를 600 nm에서 opticaldensity (O.D)값이 0.5 (1 x 106 CFU/ml)가 되게 한 후 0.7 % 한천이 첨가된 고체배지 (Tryptic Soy Broth)에 균을 도말한다. 멸균된 paper disc 8 mm (Advantec, Tokyo, Japan)를 배지 표면에 올려놓고, DMSO로 희석한 TB2 시료를 농도별로 흡수시킨 다음 37 ℃에서 24h 동안 배양 후 disc 주위의 clear zone을 측정하였다. Clear zone은 paper disc의 직경을 포함하지 않았다. 결과를 도 6(A)에 나타내었다.Antibacterial activity was measured using paper discs using disc diffusion assay. Each pure isolated bacterium was taken, inoculated into 10 ml of liquid medium (Tryptic Soy Broth), and cultured three times for 24 hours each at the optimal growth temperature for each bacterium, and then used as an antibacterial activity test bacterium. After adjusting the concentration of each test bacteria to an optical density (OD) value of 0.5 (1 A sterilized paper disc of 8 mm (Advantec, Tokyo, Japan) was placed on the surface of the medium, TB2 samples diluted with DMSO were absorbed at each concentration, and the clear zone around the disc was measured after incubation at 37°C for 24 h. Clear zone did not include the diameter of the paper disc. The results are shown in Figure 6(A).
6-3. 항균 확인 : 최소저해농도(Minimum inhibitory concentration, MIC)6-3. Antibacterial confirmation: Minimum inhibitory concentration (MIC)
한약재 혼합 추출물(TB2)을 micro-well dilution법를 참고하여, 병원성 미생물에 대한 최소저해농도를 확인하였다. 구체적으로, 액체배지(Tryptic Soy Broth)에 배양된 각 균주를 96-웰 플레이트에 1 x 106 CFU/ml로 100 μl씩 분주하였고, TB2 시료는 2배 희석법을 이용하여 DMSO로 농도를 희석한 후에 100 μl씩 분주하였다. 그후, Epoch Microplate Spectrophotometer(BioTek, Winooski Vermont, USA)를 이용하여 600 nm에서 흡광도를 측정하였다. 흡광도를 측정한 96-well plate를 37℃에서 24시간 배양한 후 동일한 파장에서 흡광도를 측정하여 흡광도의 증가가 나타나지 않는 최소 농도를 확인하였다. 결과를 도 6(B)에 나타내었다.The minimum inhibitory concentration of the herbal medicine mixed extract (TB2) against pathogenic microorganisms was confirmed by referring to the micro-well dilution method. Specifically, 100 μl of each strain cultured in tryptic soy broth was dispensed into 96-well plates at 1 x 10 6 CFU/ml, and the TB2 sample was diluted with DMSO using a 2-fold dilution method. Afterwards, 100 μl was dispensed. Afterwards, absorbance was measured at 600 nm using an Epoch Microplate Spectrophotometer (BioTek, Winooski Vermont, USA). The 96-well plate whose absorbance was measured was incubated at 37°C for 24 hours, and then the absorbance was measured at the same wavelength to confirm the minimum concentration at which no increase in absorbance occurred. The results are shown in Figure 6(B).
7. 보습과 피부장벽 강화 효과 : qRT-PCR 방법으로 mRNA 발현측정7. Moisturizing and skin barrier strengthening effect: mRNA expression measurement using qRT-PCR method
피부장벽은 각질형성세포의 분화 말기과정에서 분비되는 분화 인자들에 의해 각질세포 외막을 형성함으로써 물리적 장벽의 구조적 지지대를 만들고 보습과 관련된 정상적인 기능을 유지하게 된다. 한약재 혼합 추출물 (TB2)이 보습과 피부장벽 기능에 미치는 영향을 알아보기 위하여 각질형성세포 분화관련 인자의 mRNA 발현 증가를 확인하였다.The skin barrier forms a keratinocyte outer membrane by differentiation factors secreted during the final stage of keratinocyte differentiation, thereby creating a structural support for the physical barrier and maintaining normal functions related to moisturizing. To investigate the effect of mixed extract of herbal medicine (TB2) on moisturizing and skin barrier function, an increase in mRNA expression of factors related to keratinocyte differentiation was confirmed.
구체적으로 각질형성세포인 HaCaT 세포를 6-웰 플레이트에 2×104 cells/well로 분주하고 세포가 부착되면 TB2 시료를 농도별로 처리하여, 24시간 더 배양하였다. 양성대조군으로는 CaCl2 (1.5 nM)를 처리하였다. 배양 후 TrizolTM (Ambion, Thermo, USA)로 total RNA를 추출하고 cDNA 합성 키트 (ECDNA100, NanoHelix, Daejeon, Korea)를 이용하여 cDNA를 합성하였다. 이후 프리미어 qPCR 키트 (PQL-S500, NanoHelix, Daejeon, Korea)를 사용하여 Real-Time PCR (polymerase chain reaction) (CFX Connect, Biorad) 기계로 하기 표 3의 프라이머 세트를 이용하여 mRNA 발현량을 측정하였으며, 결과를 도 7에 나타내었다.Specifically, HaCaT cells, which are keratinocytes, were distributed in a 6-well plate at 2×10 4 cells/well, and when the cells attached, TB2 samples were treated at different concentrations and cultured for an additional 24 hours. As a positive control group, CaCl 2 (1.5 nM) was treated. After culturing, total RNA was extracted with TrizolTM (Ambion, Thermo, USA), and cDNA was synthesized using a cDNA synthesis kit (ECDNA100, NanoHelix, Daejeon, Korea). Afterwards, the mRNA expression level was measured using the primer set in Table 3 below using a Real-Time PCR (polymerase chain reaction) (CFX Connect, Biorad) machine using a Premier qPCR kit (PQL-S500, NanoHelix, Daejeon, Korea). , the results are shown in Figure 7.
8. 통계처리8. Statistical processing
실험은 3회 이상 반복한 값을 평균±표준오차(mean±SEM)로 나타내었다. 각 평균치 차이에 대한 유의성은 SPSS 26.0 version(SPSS Inc., Chicago, IL, USA) 프로그램을 이용하여 one-way analysis of variance(ANOVA)로 Tukey HSD 다중분석법으로 사후검증하거나t-test를 사용하였으며, p 값은 <0.05 미만일 때 통계적으로 유의성이 있다고 판정하였다.The experiment was repeated three or more times and was expressed as mean ± standard error (mean ± SEM). The significance of each mean difference was post hoc tested using one-way analysis of variance (ANOVA) using the SPSS 26.0 version (SPSS Inc., Chicago, IL, USA) program, Tukey HSD multiple analysis, or t-test. The p value was judged to be statistically significant when it was less than <0.05.
[실험결과][Experiment result]
1. 독성평가1. Toxicity evaluation
도 1에서 확인할 수 있는 것처럼, 본 발명의 한약재 혼합 추출물 (TB2)은 인간피부각질형성세포 (HaCaT)에서 4 % (w/v)까지, 면역관련 비만세포 (RBL-2H3)에서는 TB2 2 % (w/v)까지 세포독성이 없는 것을 확인하였다. 염증관련 대식세포 (RAW246.7)에서는 4 % (w/v)에서 90% 이상의 세포 생존률을 나타냄으로써 세포독성이 없는 것으로 판단하였다. As can be seen in Figure 1, the herbal medicine mixed extract (TB2) of the present invention increases up to 4% (w/v) in human skin keratinocytes (HaCaT) and up to 2% (w/v) of TB2 in immune-related mast cells (RBL-2H3). w/v), it was confirmed that there was no cytotoxicity. Inflammation-related macrophages (RAW246.7) showed a cell survival rate of more than 90% at 4% (w/v), indicating no cytotoxicity.
2. 항산화 효과2. Antioxidant effect
도 2에서 확인할 수 있는 것처럼, 본 발명의 한약재 혼합 추출물 (TB2)은 0.625 % (w/v)부터 유의적으로 DPPH 활성산소 소거율이 증가하였다. 또한, 본 발명의 한약재 혼합 추출물(TB2)은 용량 의존적으로 DPPH 활성산소 소거율이 증가하는 것을 확인할 수 있었으며, 이는 양성 대조군인 아스코르빈산 (AA) 수준인 것으로 높은 항상화 효과를 가진다.As can be seen in Figure 2, the herbal medicine mixed extract (TB2) of the present invention significantly increased the DPPH oxygen radical scavenging rate starting from 0.625% (w/v). In addition, the herbal medicine mixed extract (TB2) of the present invention was confirmed to increase the DPPH oxygen radical scavenging rate in a dose-dependent manner, which is at the level of ascorbic acid (AA), a positive control, and has a high antioxidant effect.
3. 면역증강 효과3. Immune strengthening effect
도 3에서 확인할 수 있는 것처럼, 본 발명의 한약재 혼합 추출물(TB2)은 면역증강 물질인 Nitric oxide (NO)가 0.5% (w/v) 이상부터 높은 유의성 (p<0.01)으로 분비가 증가하는 것을 확인할 수 있었다.As can be seen in Figure 3, the herbal medicine mixed extract (TB2) of the present invention shows a significant (p<0.01) increase in secretion of Nitric oxide (NO), an immune-boosting substance, from 0.5% (w/v) or more. I was able to confirm.
4. 항염증 효과4. Anti-inflammatory effect
도 4에서 확인할 수 있는 것처럼, 본 발명의 한약재 혼합 추출물 (TB2)은 염증 유발물질인 COX-2, TNF-α 및 iNOS의 생성을 억제하는 것을 확인할 수 있었다.As can be seen in Figure 4, it was confirmed that the herbal medicine mixed extract (TB2) of the present invention inhibits the production of inflammatory substances COX-2, TNF-α, and iNOS.
도 4(A)의 COX-2는 염증유발물질 프로스타글란딘 (PG: prostaglandin) 생합성의 주요 효소이며, 특히, COX-2 억제 효과는 최근 ㈜화이자社가 상용화에 성공한 Celebrex® 항염증 치료제의 주요 작용 기전으로 알려져 있다. 측정 결과 TB2는 LPS에 의해 증가된 COX-2의 발현을 모두 유의적으로 감소시켰다. TB2 1 % (w/v) 처리군에서는 양성대조군 수준으로 낮추는 효과를 나타내었다. COX-2 in Figure 4(A) is a major enzyme in the biosynthesis of the inflammatory substance prostaglandin (PG: prostaglandin), and in particular, the COX-2 inhibitory effect is the main mechanism of action of Celebrex ® anti-inflammatory treatment, which was recently commercialized successfully by Pfizer. It is known as As a result of the measurement, TB2 significantly reduced the expression of COX-2 increased by LPS. In the TB2 1% (w/v) treatment group, the effect was lowered to the level of the positive control group.
도 4(B)의 TNF-α는 면역세포가 분비하는 주요한 만성염증 유발 사이토카인 (cytokine)이다. 피부염증, 류마티스관절염 등을 포함하여 대부분의 염증 질환에서 증가되어 있는 인자이며 대표적인 염증반응 유발인자로 알려져 있다. 측정 결과 TB2는 LPS에 의해 증가된 TNF-α의 발현을 모두 유의적으로 감소시켰다.TNF-α, shown in Figure 4(B), is a major chronic inflammation-inducing cytokine secreted by immune cells. It is a factor that is increased in most inflammatory diseases, including skin inflammation and rheumatoid arthritis, and is known to be a representative inflammatory response trigger. As a result of the measurement, TB2 significantly reduced the expression of TNF-α increased by LPS.
도 4(C)의 iNOS는 lipopolysaccharide (LPS) 또는 염증성 cytokine 등에 의해 발현이 증가하여 과도한 NO를 생성하게 하는 유도성(inducible) 염증관련 효소이다. iNOS의 증가는 염증 반응을 심화시켜 조직의 손상, 유전자 변이 및 신경손상 등을 일으키는 것으로 알려져있다. 측정 결과 TB2 처리는 0.05 % (w/v)부터 유의적으로 LPS에 의해 증가된 iNOS의 발현을 감소시켰다. iNOS, shown in Figure 4(C), is an inducible inflammation-related enzyme whose expression increases due to lipopolysaccharide (LPS) or inflammatory cytokines, resulting in excessive NO production. It is known that an increase in iNOS intensifies the inflammatory response, causing tissue damage, genetic mutation, and nerve damage. As a result, TB2 treatment significantly reduced the expression of iNOS, which was increased by LPS, starting from 0.05% (w/v).
5. 항알러지 효과5. Anti-allergy effect
도 5에서 확인할 수 있는 것처럼, 본 발명의 한약재 혼합 추출물(TB2)은 처리된 모든 농도에서 알러젠 감작에 의해 증가된 β-hexosaminidase 분비를 유의적으로 감소시켰다. 이는 알러젠 자극에 의한 히스타민 (histamine) 분비 억제 효과로 항히스타민 효과가 있음을 의미한다.As can be seen in Figure 5, the herbal medicine mixed extract (TB2) of the present invention significantly reduced the secretion of β-hexosaminidase increased by allergen sensitization at all treated concentrations. This means that it has an antihistamine effect by suppressing histamine secretion caused by allergen stimulation.
6. 항균 및 여드름 치료 효과6. Antibacterial and acne treatment effect
도 6(A)에서 확인할 수 있는 것처럼, 본 발명의 한약재 혼합 추출물 (TB2)은 여드름균 (Propionibacterium acnes)에서 0.5 % (w/v) 부터, 황색포도상구균 (Staphylococcus aureus)에서 0.5 % (w/v) 부터, 대장균 (Escherichia coli)에서 0.1 % (w/v) 부터 육안으로 확인될 수 있는 clear zone의 항균활성을 나타내었다.As can be seen in Figure 6(A), the herbal medicine mixed extract (TB2) of the present invention has an amount ranging from 0.5% (w/v) in Propionibacterium acnes and 0.5% (w/v) in Staphylococcus aureus . From v), Escherichia coli showed antibacterial activity in a clear zone that could be confirmed with the naked eye starting from 0.1% (w/v).
도 6(B)에서 확인할 수 있는 것처럼, 항균활성에 있어서 그 최소저해농도를 확인해본 결과 본 발명의 한약재 혼합 추출물 (TB2)은 여드름균 (Propionibacterium acnes)에서 0.3 % (w/v), 황색포도상구균 (Staphylococcus aureus)에서 0.3 % (w/v), 대장균 (Escherichia coli)에서 0.1 % (w/v)에서 균이 성장하지 않는 최소저해농도임을 확인하였다.As can be seen in Figure 6(B), the minimum inhibitory concentration in terms of antibacterial activity was confirmed, and as a result, the mixed extract of herbal medicine (TB2) of the present invention was 0.3% (w/v) in Propionibacterium acnes and yellow grapes. It was confirmed that the minimum inhibitory concentration at which bacteria do not grow was 0.3% (w/v) for Staphylococcus aureus and 0.1% (w/v) for Escherichia coli .
7. 보습과 피부장벽 강화 효과7. Moisturizing and skin barrier strengthening effect
도 7에서 확인할 수 있는 것처럼, 본 발명에서 TB2 처리는 피부장벽을 구성하는 구조단백질과 보습인자인 Filaggrin의 mRNA 발현을 TB2 시료 1 % (w/v)에서 유의성 있게 증가시켰고, Loricrin의 mRNA 발현은 TB2 시료 0.1 % (w/v) 처리군 부터 유의적으로 증가시켰다.As can be seen in Figure 7, in the present invention, TB2 treatment significantly increased the mRNA expression of Filaggrin, a structural protein constituting the skin barrier and a moisturizing factor, in 1% (w/v) of TB2 samples, and the mRNA expression of Loricrin was TB2 samples significantly increased starting from the 0.1% (w/v) treatment group.
이상에서 살펴본 바와 같이, 본 발명은 상기에 언급된 바람직한 실시예로서 설명되었으나, 본 발명 분야의 통상의 기술자들은 동일한 기술적 범위 내에서 다른 구성요소를 추가, 변경, 삭제 등을 통하여, 퇴보적인 다른 발명이나 본 발명 사상의 범위 내에 포함되는 다른 실시예를 용이하게 제안할 수 있을 것이다. 그러므로 이상에서 기술한 실시예들은 모든 면에서 예시적인 것이며 본 발명의 범위를 한정하는 것이 아니다.As seen above, the present invention has been described as the preferred embodiment mentioned above, but those skilled in the art will find that other regressive inventions can be found by adding, changing, deleting, etc. other components within the same technical scope. However, other embodiments that are included within the scope of the present invention can be easily proposed. Therefore, the embodiments described above are illustrative in all respects and do not limit the scope of the present invention.
Claims (8)
A functional cosmetic for antioxidant, immune-boosting, anti-inflammatory, anti-allergic, anti-bacterial, acne improvement, moisturizing, and skin barrier strengthening containing as active ingredients the extracts of herbacea, angelica root, licorice, white peony, perilla leaf, honeysuckle, perilla, milky white bark, and yellow lotus mixed extract. Composition.
상기 조성물은 COX-2, TNF-α 및 iNOS의 생성을 억제시키는 것인, 기능성 화장료 조성물.
According to paragraph 1,
The composition is a functional cosmetic composition that inhibits the production of COX-2, TNF-α and iNOS.
상기 조성물은 Fillagrin 및 Loricrin을 증가시키는 것인, 기능성 화장료 조성물.
According to paragraph 1,
The composition is a functional cosmetic composition that increases Fillagrin and Loricrin.
상기 조성물은 히스타민 분비효소를 억제시키는 것인, 기능성 화장료 조성물.
According to paragraph 1,
The composition is a functional cosmetic composition that inhibits histamine secreting enzyme.
상기 조성물은 여드름균 (Propionibacterium acnes), 황색포도상구균 (Staphylococcus aureus) 및 대장균 (Escherichia coli)의 증식을 억제시키는 것인, 기능성 화장료 조성물.
According to paragraph 1,
The composition is a functional cosmetic composition that inhibits the growth of Propionibacterium acnes, Staphylococcus aureus , and Escherichia coli .
A cosmetic composition for preventing or improving atopy containing as active ingredients a mixed extract of Japanese herb, angelica root, licorice, white peony, perilla leaves, honeysuckle, perilla, milky bark, and yellow lotus.
Antioxidant, immune-boosting, anti-inflammatory, anti-allergic, anti-bacterial, acne improvement, moisturizing and skin barrier strengthening health functions, including extracts of Japanese herb, angelica root, licorice, white peony, perilla leaf, honeysuckle, perilla leaf, milky white bark and yellow lotus mixed extract as active ingredients. Food composition.
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