KR20240007137A - 소르틸린 활성 조절제 - Google Patents
소르틸린 활성 조절제 Download PDFInfo
- Publication number
- KR20240007137A KR20240007137A KR1020237037614A KR20237037614A KR20240007137A KR 20240007137 A KR20240007137 A KR 20240007137A KR 1020237037614 A KR1020237037614 A KR 1020237037614A KR 20237037614 A KR20237037614 A KR 20237037614A KR 20240007137 A KR20240007137 A KR 20240007137A
- Authority
- KR
- South Korea
- Prior art keywords
- formamido
- alkyl
- hydroxyphenyl
- halo
- propanamido
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 235000020357 syrup Nutrition 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 229960001367 tartaric acid Drugs 0.000 description 1
- 125000004213 tert-butoxy group Chemical group [H]C([H])([H])C(O*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- CZDYPVPMEAXLPK-UHFFFAOYSA-N tetramethylsilane Chemical compound C[Si](C)(C)C CZDYPVPMEAXLPK-UHFFFAOYSA-N 0.000 description 1
- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 230000005945 translocation Effects 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
- 238000001665 trituration Methods 0.000 description 1
- 108010038745 tryptophylglycine Proteins 0.000 description 1
- 238000001946 ultra-performance liquid chromatography-mass spectrometry Methods 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 108010009962 valyltyrosine Proteins 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 108010027345 wheylin-1 peptide Proteins 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1027—Tetrapeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Sawing (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Secondary Cells (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP21173972.7A EP4089102A1 (en) | 2021-05-14 | 2021-05-14 | Modulators of sortilin activity |
| EP21173972.7 | 2021-05-14 | ||
| PCT/EP2022/063049 WO2022238565A2 (en) | 2021-05-14 | 2022-05-13 | Compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20240007137A true KR20240007137A (ko) | 2024-01-16 |
Family
ID=75936805
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020237037614A Pending KR20240007137A (ko) | 2021-05-14 | 2022-05-13 | 소르틸린 활성 조절제 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20240294569A1 (https=) |
| EP (2) | EP4089102A1 (https=) |
| JP (1) | JP2024517498A (https=) |
| KR (1) | KR20240007137A (https=) |
| CN (1) | CN117642416A (https=) |
| AU (1) | AU2022275011A1 (https=) |
| CA (1) | CA3217317A1 (https=) |
| WO (1) | WO2022238565A2 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4361165A1 (en) * | 2022-10-24 | 2024-05-01 | Insusense ApS | Modulators of sortilin activity |
| EP4471047A1 (en) * | 2023-05-31 | 2024-12-04 | Insusense ApS | Modulators of sortilin activity |
| JP2026509275A (ja) * | 2023-03-07 | 2026-03-17 | ベスパー バイオ アーペーエス | ソルチリン修飾剤 |
| EP4428121A1 (en) * | 2023-03-07 | 2024-09-11 | Vesper Bio Aps | Modulators of sortilin activity |
| EP4428122A1 (en) * | 2023-03-07 | 2024-09-11 | Vesper Bio Aps | Sortiline modulators |
| EP4428124A1 (en) * | 2023-03-07 | 2024-09-11 | Vesper Bio Aps | Modulators of sortilin activity |
| EP4719366A1 (en) | 2023-05-26 | 2026-04-08 | Bertram Wiedenmann | Sortilin inhibitors for treatment of patients with functional neuroendocrine tumors |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW217417B (https=) * | 1991-12-04 | 1993-12-11 | Manyu Seiyaku Kk | |
| HUE030465T2 (hu) | 2009-05-13 | 2017-05-29 | Antivirális vegyületek | |
| EP2948147B1 (en) * | 2013-01-28 | 2019-03-13 | H. Lundbeck A/S | N-substituted-5-substituted phthalamic acids as sortilin inhibitors |
| WO2015131100A1 (en) | 2014-02-28 | 2015-09-03 | The Scripps Research Institute | Ligand-controlled c(sp3)-h arylation and olefination in synthesis of unnatural chiral alpha amino acids |
| US20160331746A1 (en) | 2015-05-12 | 2016-11-17 | University Of South Florida | Sortilin-Binding Small Molecules for Increasing Glucose Uptake |
| AU2017361155B2 (en) * | 2016-11-15 | 2023-03-30 | Tokyo University Of Science Foundation | Ras protein degradation inducing molecule and pharmaceutical composition |
| CN109280075B (zh) * | 2017-07-21 | 2022-05-20 | 四川海思科制药有限公司 | 肽酰胺类化合物及其制备方法和在医药上的用途 |
-
2021
- 2021-05-14 EP EP21173972.7A patent/EP4089102A1/en not_active Withdrawn
-
2022
- 2022-05-13 CN CN202280032903.0A patent/CN117642416A/zh active Pending
- 2022-05-13 AU AU2022275011A patent/AU2022275011A1/en not_active Abandoned
- 2022-05-13 US US18/559,672 patent/US20240294569A1/en active Pending
- 2022-05-13 EP EP22728903.0A patent/EP4337674A2/en active Pending
- 2022-05-13 CA CA3217317A patent/CA3217317A1/en active Pending
- 2022-05-13 KR KR1020237037614A patent/KR20240007137A/ko active Pending
- 2022-05-13 WO PCT/EP2022/063049 patent/WO2022238565A2/en not_active Ceased
- 2022-05-13 JP JP2023570456A patent/JP2024517498A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN117642416A (zh) | 2024-03-01 |
| US20240294569A1 (en) | 2024-09-05 |
| EP4089102A1 (en) | 2022-11-16 |
| WO2022238565A3 (en) | 2023-02-23 |
| AU2022275011A1 (en) | 2023-11-23 |
| EP4337674A2 (en) | 2024-03-20 |
| AU2022275011A9 (en) | 2023-11-30 |
| JP2024517498A (ja) | 2024-04-22 |
| CA3217317A1 (en) | 2022-11-17 |
| WO2022238565A2 (en) | 2022-11-17 |
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Patent event date: 20231031 Patent event code: PA01051R01D Comment text: International Patent Application |
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