CN117642416A - 分拣蛋白活性调节剂 - Google Patents
分拣蛋白活性调节剂 Download PDFInfo
- Publication number
- CN117642416A CN117642416A CN202280032903.0A CN202280032903A CN117642416A CN 117642416 A CN117642416 A CN 117642416A CN 202280032903 A CN202280032903 A CN 202280032903A CN 117642416 A CN117642416 A CN 117642416A
- Authority
- CN
- China
- Prior art keywords
- propionylamino
- hydroxyphenyl
- alkyl
- acid
- ser
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1027—Tetrapeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Sawing (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Secondary Cells (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP21173972.7A EP4089102A1 (en) | 2021-05-14 | 2021-05-14 | Modulators of sortilin activity |
| EP21173972.7 | 2021-05-14 | ||
| PCT/EP2022/063049 WO2022238565A2 (en) | 2021-05-14 | 2022-05-13 | Compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN117642416A true CN117642416A (zh) | 2024-03-01 |
Family
ID=75936805
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202280032903.0A Pending CN117642416A (zh) | 2021-05-14 | 2022-05-13 | 分拣蛋白活性调节剂 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20240294569A1 (https=) |
| EP (2) | EP4089102A1 (https=) |
| JP (1) | JP2024517498A (https=) |
| KR (1) | KR20240007137A (https=) |
| CN (1) | CN117642416A (https=) |
| AU (1) | AU2022275011A1 (https=) |
| CA (1) | CA3217317A1 (https=) |
| WO (1) | WO2022238565A2 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4361165A1 (en) * | 2022-10-24 | 2024-05-01 | Insusense ApS | Modulators of sortilin activity |
| EP4471047A1 (en) * | 2023-05-31 | 2024-12-04 | Insusense ApS | Modulators of sortilin activity |
| JP2026509275A (ja) * | 2023-03-07 | 2026-03-17 | ベスパー バイオ アーペーエス | ソルチリン修飾剤 |
| EP4428121A1 (en) * | 2023-03-07 | 2024-09-11 | Vesper Bio Aps | Modulators of sortilin activity |
| EP4428122A1 (en) * | 2023-03-07 | 2024-09-11 | Vesper Bio Aps | Sortiline modulators |
| EP4428124A1 (en) * | 2023-03-07 | 2024-09-11 | Vesper Bio Aps | Modulators of sortilin activity |
| EP4719366A1 (en) | 2023-05-26 | 2026-04-08 | Bertram Wiedenmann | Sortilin inhibitors for treatment of patients with functional neuroendocrine tumors |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW217417B (https=) * | 1991-12-04 | 1993-12-11 | Manyu Seiyaku Kk | |
| HUE030465T2 (hu) | 2009-05-13 | 2017-05-29 | Antivirális vegyületek | |
| EP2948147B1 (en) * | 2013-01-28 | 2019-03-13 | H. Lundbeck A/S | N-substituted-5-substituted phthalamic acids as sortilin inhibitors |
| WO2015131100A1 (en) | 2014-02-28 | 2015-09-03 | The Scripps Research Institute | Ligand-controlled c(sp3)-h arylation and olefination in synthesis of unnatural chiral alpha amino acids |
| US20160331746A1 (en) | 2015-05-12 | 2016-11-17 | University Of South Florida | Sortilin-Binding Small Molecules for Increasing Glucose Uptake |
| AU2017361155B2 (en) * | 2016-11-15 | 2023-03-30 | Tokyo University Of Science Foundation | Ras protein degradation inducing molecule and pharmaceutical composition |
| CN109280075B (zh) * | 2017-07-21 | 2022-05-20 | 四川海思科制药有限公司 | 肽酰胺类化合物及其制备方法和在医药上的用途 |
-
2021
- 2021-05-14 EP EP21173972.7A patent/EP4089102A1/en not_active Withdrawn
-
2022
- 2022-05-13 CN CN202280032903.0A patent/CN117642416A/zh active Pending
- 2022-05-13 AU AU2022275011A patent/AU2022275011A1/en not_active Abandoned
- 2022-05-13 US US18/559,672 patent/US20240294569A1/en active Pending
- 2022-05-13 EP EP22728903.0A patent/EP4337674A2/en active Pending
- 2022-05-13 CA CA3217317A patent/CA3217317A1/en active Pending
- 2022-05-13 KR KR1020237037614A patent/KR20240007137A/ko active Pending
- 2022-05-13 WO PCT/EP2022/063049 patent/WO2022238565A2/en not_active Ceased
- 2022-05-13 JP JP2023570456A patent/JP2024517498A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| KR20240007137A (ko) | 2024-01-16 |
| US20240294569A1 (en) | 2024-09-05 |
| EP4089102A1 (en) | 2022-11-16 |
| WO2022238565A3 (en) | 2023-02-23 |
| AU2022275011A1 (en) | 2023-11-23 |
| EP4337674A2 (en) | 2024-03-20 |
| AU2022275011A9 (en) | 2023-11-30 |
| JP2024517498A (ja) | 2024-04-22 |
| CA3217317A1 (en) | 2022-11-17 |
| WO2022238565A2 (en) | 2022-11-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN117642416A (zh) | 分拣蛋白活性调节剂 | |
| US20240217922A1 (en) | Modulators of sortilin activity | |
| WO2022074119A1 (en) | A sortilin antagonist for use in the prevention or treatment of hearing loss | |
| JP2024537619A (ja) | 中枢神経系の疾患の処置における使用のためのソルチリンモジュレーターとしての２－アミノ－５，５－ジメチルヘキサン酸誘導体 | |
| JP2025508927A (ja) | ソルチリン依存性疾患を治療するためのアミノ酸ベースのカルバメート及び／又は尿素 | |
| US20240132514A1 (en) | Pyridine derivatives as modulators of sortilin activity | |
| EP4428121A1 (en) | Modulators of sortilin activity | |
| EP4428124A1 (en) | Modulators of sortilin activity |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB02 | Change of applicant information |
Country or region after: Denmark Address after: Tanba Goro haro Applicant after: Wisper Biological Applications Co.,Ltd. Address before: Tanba Goro haro Applicant before: Innocence Ltd. Country or region before: Denmark |
|
| CB02 | Change of applicant information | ||
| CB02 | Change of applicant information |
Country or region after: Denmark Address after: Room 4, 10 Hauser Street, Copenhagen, Denmark Applicant after: Wisper Biological Applications Co.,Ltd. Address before: Tanba Goro haro Applicant before: Wisper Biological Applications Co.,Ltd. Country or region before: Denmark |
|
| CB02 | Change of applicant information |