KR20240005720A - Adgre2 및/또는 clec12a를 표적으로 하는 키메라 수용체 및 이의 용도 - Google Patents

Adgre2 및/또는 clec12a를 표적으로 하는 키메라 수용체 및 이의 용도 Download PDF

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KR20240005720A
KR20240005720A KR1020237037607A KR20237037607A KR20240005720A KR 20240005720 A KR20240005720 A KR 20240005720A KR 1020237037607 A KR1020237037607 A KR 1020237037607A KR 20237037607 A KR20237037607 A KR 20237037607A KR 20240005720 A KR20240005720 A KR 20240005720A
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seq
amino acid
acid sequence
set forth
sequence set
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Korean (ko)
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마이클 사델라인
샤샤 피. 하우브너
조지 만실라-소토
게리 샤피로
싱위에 허
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메모리얼 슬로안 케터링 캔서 센터
슬로안-케테링인스티튜트퍼캔서리서치
메모리얼 하스피틀 포 캔서 앤드 얼라이드 디지즈스
밀레니엄 파머슈티컬스 인코퍼레이티드
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Publication of KR20240005720A publication Critical patent/KR20240005720A/ko
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KR1020237037607A 2021-04-26 2022-04-25 Adgre2 및/또는 clec12a를 표적으로 하는 키메라 수용체 및 이의 용도 Pending KR20240005720A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202163179799P 2021-04-26 2021-04-26
US63/179,799 2021-04-26
US202163287655P 2021-12-09 2021-12-09
US63/287,655 2021-12-09
PCT/US2022/026131 WO2022232016A2 (en) 2021-04-26 2022-04-25 Chimeric receptors targeting adgre2 and/or clec12a and uses thereof

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KR20240005720A true KR20240005720A (ko) 2024-01-12

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KR1020237037607A Pending KR20240005720A (ko) 2021-04-26 2022-04-25 Adgre2 및/또는 clec12a를 표적으로 하는 키메라 수용체 및 이의 용도

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US (2) US12331129B2 (https=)
EP (1) EP4330275A4 (https=)
JP (1) JP2024514974A (https=)
KR (1) KR20240005720A (https=)
AU (1) AU2022267219A1 (https=)
BR (1) BR112023022297A2 (https=)
CA (1) CA3212596A1 (https=)
CL (1) CL2023003185A1 (https=)
CO (1) CO2023015212A2 (https=)
EC (1) ECSP23081501A (https=)
IL (1) IL306141A (https=)
MX (1) MX2023012681A (https=)
PE (1) PE20250158A1 (https=)
TW (1) TW202305004A (https=)
WO (1) WO2022232016A2 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2023011712A (es) 2021-04-26 2023-10-12 Millennium Pharm Inc Anticuerpos anti receptor de adhesion acoplado a proteinas g e2 (adgre2) y usos de los mismos.
CA3216770A1 (en) * 2021-04-26 2022-11-03 Tomoki Yoshihara Anti-clec12a antibodies and uses thereof
CN120152735A (zh) * 2022-10-25 2025-06-13 武田药品工业株式会社 Adgre2嵌合受体nk细胞组合物和使用方法
WO2024238565A1 (en) * 2023-05-15 2024-11-21 Vor Biopharma Inc. Egf-like module containing mucin-like hormone-like 2 (erm2) binding agents and methods of use thereof
WO2025243243A1 (en) * 2024-05-24 2025-11-27 Janssen Biotech, Inc. Bispecific antibody targeting emr2 (cd312) and the t-cell receptor trbv19

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5091513A (en) 1987-05-21 1992-02-25 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
US5132405A (en) 1987-05-21 1992-07-21 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
JPS6412935A (en) 1987-07-02 1989-01-17 Mitsubishi Electric Corp Constant-speed travel device for vehicle
US5399346A (en) 1989-06-14 1995-03-21 The United States Of America As Represented By The Department Of Health And Human Services Gene therapy
US20020018783A1 (en) 1997-03-20 2002-02-14 Michel Sadelain Fusion proteins of a single chain antibody and cd28 and uses thereof
US6436703B1 (en) 2000-03-31 2002-08-20 Hyseq, Inc. Nucleic acids and polypeptides
US9260525B2 (en) * 2008-02-04 2016-02-16 Xiao-Jia Chang Antibody molecules to oncogenic isoforms of fibroblast growth factor receptor-2 and uses thereof
WO2014087010A1 (en) 2012-12-07 2014-06-12 Ablynx N.V. IMPROVED POLYPEPTIDES DIRECTED AGAINST IgE
BR112018010279A2 (pt) 2015-11-19 2019-02-05 Abbvie Stemcentrx Llc novos anticorpos anti-emr2 e métodos de uso
WO2018027197A1 (en) 2016-08-04 2018-02-08 Memorial Sloan-Kettering Cancer Center Cancer antigen targets and uses thereof
JOP20190187A1 (ar) * 2017-02-03 2019-08-01 Novartis Ag مترافقات عقار جسم مضاد لـ ccr7
JP7416695B2 (ja) * 2017-12-29 2024-01-17 メモリアル スローン-ケタリング キャンサー センター 増強されたキメラ抗原受容体およびその使用
MX2020007338A (es) 2018-01-09 2020-11-06 H Lee Moffitt Cancer Ct & Res Composiciones y métodos para el direccionamiento a tipos de cáncer que expresan clec12a.
WO2019157454A1 (en) 2018-02-11 2019-08-15 Memorial Sloan-Kettering Cancer Center Non-hla restricted t cell receptors and uses thereof
WO2020020281A1 (zh) * 2018-07-25 2020-01-30 信达生物制药(苏州)有限公司 抗tigit抗体及其用途
JP7575100B2 (ja) 2018-11-13 2024-10-29 ジェイエヌ バイオサイエンシーズ エルエルシー 免疫細胞活性化のための二重特異性抗体
TW202110873A (zh) * 2019-04-30 2021-03-16 美商聖堤生物科技股份有限公司 嵌合受體及其使用方法
BR112021020999A2 (pt) 2019-05-04 2021-12-14 Inhibrx Inc Polipeptídeos de ligação à clec12a e usos dos mesmos
WO2020232165A1 (en) * 2019-05-14 2020-11-19 Qlb Biotherapeutics Bispecific anti-cd3 x cd20 antibodies and uses thereof
CN114450395A (zh) 2019-05-16 2022-05-06 华盛顿大学 Lockr介导的car t细胞募集
JP7512394B2 (ja) 2020-05-06 2024-07-08 ドラゴンフライ セラピューティクス, インコーポレイテッド Nkg2d、cd16及びclec12aに結合するタンパク質
MX2023011712A (es) 2021-04-26 2023-10-12 Millennium Pharm Inc Anticuerpos anti receptor de adhesion acoplado a proteinas g e2 (adgre2) y usos de los mismos.
CA3216770A1 (en) 2021-04-26 2022-11-03 Tomoki Yoshihara Anti-clec12a antibodies and uses thereof

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CL2023003185A1 (es) 2024-04-26
CA3212596A1 (en) 2022-11-03
EP4330275A2 (en) 2024-03-06
AU2022267219A1 (en) 2023-10-05
US20220363775A1 (en) 2022-11-17
PE20250158A1 (es) 2025-01-22
CO2023015212A2 (es) 2023-11-20
EP4330275A4 (en) 2026-04-08
JP2024514974A (ja) 2024-04-03
US12331129B2 (en) 2025-06-17
US20250250356A1 (en) 2025-08-07
WO2022232016A3 (en) 2023-01-05
ECSP23081501A (es) 2023-11-30
WO2022232016A2 (en) 2022-11-03
TW202305004A (zh) 2023-02-01
BR112023022297A2 (pt) 2023-12-26
MX2023012681A (es) 2023-11-07

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