KR20230175245A - 변형된 항-tslp 항체 - Google Patents
변형된 항-tslp 항체 Download PDFInfo
- Publication number
- KR20230175245A KR20230175245A KR1020237039566A KR20237039566A KR20230175245A KR 20230175245 A KR20230175245 A KR 20230175245A KR 1020237039566 A KR1020237039566 A KR 1020237039566A KR 20237039566 A KR20237039566 A KR 20237039566A KR 20230175245 A KR20230175245 A KR 20230175245A
- Authority
- KR
- South Korea
- Prior art keywords
- seq
- fragment
- tslp
- antibody
- binding protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies from serum
- C07K16/065—Purification, fragmentation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/246—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163178915P | 2021-04-23 | 2021-04-23 | |
| US63/178,915 | 2021-04-23 | ||
| PCT/US2022/025999 WO2022226342A2 (en) | 2021-04-23 | 2022-04-22 | Modified anti-tslp antibodies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20230175245A true KR20230175245A (ko) | 2023-12-29 |
Family
ID=81597885
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020237039566A Pending KR20230175245A (ko) | 2021-04-23 | 2022-04-22 | 변형된 항-tslp 항체 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20240182558A1 (https=) |
| EP (1) | EP4326762A2 (https=) |
| JP (1) | JP2024516595A (https=) |
| KR (1) | KR20230175245A (https=) |
| CN (1) | CN117177992A (https=) |
| AR (1) | AR125404A1 (https=) |
| AU (1) | AU2022262006A1 (https=) |
| BR (1) | BR112023022041A2 (https=) |
| CA (1) | CA3216700A1 (https=) |
| CL (1) | CL2023003124A1 (https=) |
| IL (1) | IL307439A (https=) |
| MX (1) | MX2023012325A (https=) |
| TW (1) | TW202304980A (https=) |
| WO (1) | WO2022226342A2 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12110324B2 (en) | 2022-07-22 | 2024-10-08 | Flagship Pioneering Innovations Vi, Llc | Antigen binding molecules targeting thymic stromal lymphopoietin (TSLP) |
| WO2024118542A1 (en) * | 2022-11-28 | 2024-06-06 | Takeda Vaccines, Inc. | A method for the quantitative determination of human serum albumin monomer in virus-containing pharmaceutical compositions |
| CN120513100A (zh) * | 2023-01-06 | 2025-08-19 | 江苏恒瑞医药股份有限公司 | 一种tslp抗体治疗哮喘的方法 |
| TW202448501A (zh) | 2023-02-02 | 2024-12-16 | 美商麥迪紐有限責任公司 | 用抗ｔｓｌｐ抗體治療慢性鼻竇炎 |
| CN121443636A (zh) | 2023-05-18 | 2026-01-30 | 免疫医疗有限责任公司 | 用抗tslp抗体治疗皮质类固醇依赖性哮喘 |
| WO2025147632A1 (en) | 2024-01-05 | 2025-07-10 | Medimmune, Llc | Treatment of chronic obstructive pulmonary disease with anti-tslp antibody |
| WO2025221247A1 (en) | 2024-04-17 | 2025-10-23 | Amgen Inc. | Treatment of eosinophilic esophagitis with anti-tslp antibody |
| WO2025265071A1 (en) * | 2024-06-21 | 2025-12-26 | Paragon Therapeutics, Inc. | Antibodies that bind tslp and methods of use |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| ATE300615T1 (de) | 1990-08-29 | 2005-08-15 | Genpharm Int | Transgene mäuse fähig zur produktion heterologer antikörper |
| JP4986633B2 (ja) * | 2005-01-12 | 2012-07-25 | 協和発酵キリン株式会社 | 安定化されたヒトＩｇＧ２およびＩｇＧ３抗体 |
| US7982016B2 (en) | 2007-09-10 | 2011-07-19 | Amgen Inc. | Antigen binding proteins capable of binding thymic stromal lymphopoietin |
| US8359965B2 (en) | 2007-09-17 | 2013-01-29 | Oxford J Craig | Apparatus and method for broad spectrum radiation attenuation |
| CN101874042B9 (zh) * | 2007-09-26 | 2019-01-01 | 中外制药株式会社 | 利用cdr的氨基酸取代来改变抗体等电点的方法 |
| AR082163A1 (es) | 2010-07-15 | 2012-11-14 | Hoffmann La Roche | Anticuerpos especificamente ligantes del tslpr humano y metodos de utilizacion de los mismos |
| AT510032B1 (de) | 2010-11-30 | 2012-01-15 | Steiner Erwin Ing | Montageeinrichtung für fassadenelemente |
| US9100245B1 (en) | 2012-02-08 | 2015-08-04 | Amazon Technologies, Inc. | Identifying protected media files |
| WO2014031718A1 (en) * | 2012-08-23 | 2014-02-27 | Merck Sharp & Dohme Corp. | Stable formulations of antibodies to tslp |
| US9306926B2 (en) | 2013-03-15 | 2016-04-05 | Brian A. Truong | User authentication using unique hidden identifiers |
| BR112017019412A2 (pt) * | 2015-03-11 | 2018-05-02 | Glaxosmithkline Ip Dev Ltd | proteínas ligadoras de tslp |
| KR20240070727A (ko) | 2017-04-12 | 2024-05-21 | 암젠 인크 | 항-tslp 항체를 이용한 천식의 치료 |
| MX2019014615A (es) | 2017-06-08 | 2020-02-07 | Amgen Inc | Dispositivo de administracion de farmacos accionado por par de torsion. |
| SG11202000727SA (en) * | 2017-08-01 | 2020-02-27 | Amgen Inc | Systems and methods for real time preparation of a polypeptide sample for analysis with mass spectrometry |
| CA3079665A1 (en) | 2017-11-10 | 2019-05-16 | Amgen Inc. | Plungers for drug delivery devices |
| ES3042632T3 (en) | 2018-03-13 | 2025-11-24 | Amgen Inc | Methods for the preparation of trypsin-resistant polypeptides for mass spectrometric analysis |
| EA202191038A1 (ru) | 2018-10-15 | 2021-07-06 | Эмджен Инк. | Способ платформенной сборки для устройства доставки лекарственного средства |
| MA53912A (fr) | 2018-10-15 | 2022-01-19 | Amgen Inc | Dispositif d'administration de médicament comprenant un mécanisme d'amortissement |
| MA56121A (fr) | 2019-06-05 | 2022-04-13 | Amgen Inc | Procédés d'identification d'attributs de protéines thérapeutiques |
| KR102809618B1 (ko) * | 2019-09-04 | 2025-05-16 | 바이오션, 인코포레이티드 | Tslp에 결합하는 항체 및 이의 용도 |
-
2022
- 2022-04-22 KR KR1020237039566A patent/KR20230175245A/ko active Pending
- 2022-04-22 AU AU2022262006A patent/AU2022262006A1/en active Pending
- 2022-04-22 US US18/287,597 patent/US20240182558A1/en active Pending
- 2022-04-22 AR ARP220101043A patent/AR125404A1/es unknown
- 2022-04-22 WO PCT/US2022/025999 patent/WO2022226342A2/en not_active Ceased
- 2022-04-22 MX MX2023012325A patent/MX2023012325A/es unknown
- 2022-04-22 EP EP22722641.2A patent/EP4326762A2/en active Pending
- 2022-04-22 BR BR112023022041A patent/BR112023022041A2/pt unknown
- 2022-04-22 IL IL307439A patent/IL307439A/en unknown
- 2022-04-22 JP JP2023563978A patent/JP2024516595A/ja active Pending
- 2022-04-22 CN CN202280030029.7A patent/CN117177992A/zh active Pending
- 2022-04-22 TW TW111115432A patent/TW202304980A/zh unknown
- 2022-04-22 CA CA3216700A patent/CA3216700A1/en active Pending
-
2023
- 2023-10-19 CL CL2023003124A patent/CL2023003124A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TW202304980A (zh) | 2023-02-01 |
| AR125404A1 (es) | 2023-07-12 |
| AU2022262006A1 (en) | 2023-10-19 |
| MX2023012325A (es) | 2023-10-30 |
| WO2022226342A3 (en) | 2022-12-01 |
| EP4326762A2 (en) | 2024-02-28 |
| WO2022226342A2 (en) | 2022-10-27 |
| CL2023003124A1 (es) | 2024-04-26 |
| IL307439A (en) | 2023-12-01 |
| US20240182558A1 (en) | 2024-06-06 |
| CN117177992A (zh) | 2023-12-05 |
| JP2024516595A (ja) | 2024-04-16 |
| BR112023022041A2 (pt) | 2023-12-26 |
| CA3216700A1 (en) | 2022-10-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR20230175245A (ko) | 변형된 항-tslp 항체 | |
| US20250032608A1 (en) | Treatment of asthma with anti-tsl p antibody | |
| JP2023052457A (ja) | Ｉｌ－４ｒアンタゴニストを投与することにより喘息を処置又は予防するための方法 | |
| EP3277722B1 (en) | Antibodies to canine interleukin-4 receptor alpha | |
| JP2021193121A (ja) | Ｉｌ−１７アンタゴニストを使用して汎発性膿疱性乾癬（ｇｐｐ）を処置する方法 | |
| AU2021221998A1 (en) | Formulations of human anti-TSLP antibodies and methods of using the same | |
| KR20240000537A (ko) | 항-tslp 항체 조성물 및 이의 용도 | |
| US20250340626A1 (en) | Caninized antibodies to human ngf | |
| TW201842933A (zh) | 使用il-17拮抗劑選擇性治療氣喘的方法 | |
| IL302445A (en) | Use of an IL-18 antagonist for the treatment and/or prevention of atopic dermatitis or a related condition | |
| JP7216157B2 (ja) | Ｉｌ－４ｒアンタゴニストを投与することにより喘息を処置又は予防するための方法 | |
| TW202532439A (zh) | 治療氣喘之方法 | |
| WO2025221995A1 (en) | Treatment of eosinophilic esophagitis with anti-tslp antibody | |
| CN118401549A (zh) | 人ngf的犬源化和猫源化抗体 | |
| WO2024092064A1 (en) | Anti-tslp antibody compositions and uses thereof | |
| KR20230123477A (ko) | 급성 호흡곤란 증후군의 치료 또는 예방 방법 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
Patent event date: 20231116 Patent event code: PA01051R01D Comment text: International Patent Application |
|
| PG1501 | Laying open of application | ||
| A201 | Request for examination | ||
| PA0201 | Request for examination |
Patent event code: PA02012R01D Patent event date: 20250422 Comment text: Request for Examination of Application |