KR20230152095A - 갑상선 호르몬 수용체 베타 작용제 화합물 - Google Patents
갑상선 호르몬 수용체 베타 작용제 화합물 Download PDFInfo
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- KR20230152095A KR20230152095A KR1020237032893A KR20237032893A KR20230152095A KR 20230152095 A KR20230152095 A KR 20230152095A KR 1020237032893 A KR1020237032893 A KR 1020237032893A KR 20237032893 A KR20237032893 A KR 20237032893A KR 20230152095 A KR20230152095 A KR 20230152095A
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- KR
- South Korea
- Prior art keywords
- compound
- pharmaceutically acceptable
- stereoisomer
- tautomer
- acceptable salt
- Prior art date
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- 150000001875 compounds Chemical class 0.000 title claims abstract description 291
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- 238000000034 method Methods 0.000 claims abstract description 106
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- 125000003118 aryl group Chemical group 0.000 claims description 35
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 19
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- 239000012047 saturated solution Substances 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000010898 silica gel chromatography Methods 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- OKODKVMXHLUQSW-JITBQSAISA-M sodium;(e)-4-hydroxy-4-oxobut-2-enoate;octadecanoic acid Chemical compound [Na+].OC(=O)\C=C\C([O-])=O.CCCCCCCCCCCCCCCCCC(O)=O OKODKVMXHLUQSW-JITBQSAISA-M 0.000 description 1
- 239000007905 soft elastic gelatin capsule Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 125000003003 spiro group Chemical group 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 229940032147 starch Drugs 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 150000003460 sulfonic acids Chemical class 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 238000001308 synthesis method Methods 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 description 1
- GZCRRIHWUXGPOV-UHFFFAOYSA-N terbium atom Chemical compound [Tb] GZCRRIHWUXGPOV-UHFFFAOYSA-N 0.000 description 1
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 150000003536 tetrazoles Chemical class 0.000 description 1
- 229940034208 thyroxine Drugs 0.000 description 1
- XUIIKFGFIJCVMT-UHFFFAOYSA-N thyroxine-binding globulin Natural products IC1=CC(CC([NH3+])C([O-])=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-UHFFFAOYSA-N 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
- 150000003852 triazoles Chemical class 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163156227P | 2021-03-03 | 2021-03-03 | |
| US63/156,227 | 2021-03-03 | ||
| PCT/US2022/018575 WO2022187403A1 (fr) | 2021-03-03 | 2022-03-02 | Composés agonistes bêta du récepteur de l'hormone thyroïdienne |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20230152095A true KR20230152095A (ko) | 2023-11-02 |
Family
ID=83154837
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020237032893A KR20230152095A (ko) | 2021-03-03 | 2022-03-02 | 갑상선 호르몬 수용체 베타 작용제 화합물 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20240059682A1 (fr) |
| EP (1) | EP4301357A1 (fr) |
| JP (1) | JP2024510935A (fr) |
| KR (1) | KR20230152095A (fr) |
| CN (1) | CN117120051A (fr) |
| AU (1) | AU2022228569A1 (fr) |
| BR (1) | BR112023017612A2 (fr) |
| CA (1) | CA3212130A1 (fr) |
| CL (1) | CL2023002601A1 (fr) |
| CO (1) | CO2023012684A2 (fr) |
| IL (1) | IL305495A (fr) |
| MX (1) | MX2023010324A (fr) |
| PE (1) | PE20240097A1 (fr) |
| WO (1) | WO2022187403A1 (fr) |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL54474A (en) * | 1977-04-12 | 1982-04-30 | Ciba Geigy Ag | Benzimidazole derivatives,their preparation and anthelmintic compositions containing them |
| CN105477636B (zh) * | 2015-10-16 | 2019-09-17 | 厦门大学 | 使用阿维菌素及其衍生物治疗代谢疾病的方法 |
| TW202220968A (zh) * | 2016-01-29 | 2022-06-01 | 美商維它藥物有限責任公司 | ＲＯＲ－γ調節劑 |
| JP2021535207A (ja) * | 2018-08-24 | 2021-12-16 | ターンズ・インコーポレイテッドTerns, Inc. | 甲状腺ホルモン受容体ベータアゴニスト化合物 |
| WO2020061086A2 (fr) * | 2018-09-18 | 2020-03-26 | Terns, Inc. | Composés destinés au traitement de certaines leucémies |
| WO2020077123A1 (fr) * | 2018-10-12 | 2020-04-16 | Terns, Inc. | Composés agonistes du récepteur bêta des hormones thyroïdiennes |
| CN111320609A (zh) * | 2018-12-13 | 2020-06-23 | 拓臻股份有限公司 | 一种THRβ受体激动剂化合物及其制备方法和用途 |
| PE20220255A1 (es) * | 2019-05-08 | 2022-02-16 | Aligos Therapeutics Inc | Moduladores de thr y metodos de uso de estos |
-
2022
- 2022-03-02 US US18/548,650 patent/US20240059682A1/en active Pending
- 2022-03-02 CA CA3212130A patent/CA3212130A1/fr active Pending
- 2022-03-02 EP EP22764006.7A patent/EP4301357A1/fr active Pending
- 2022-03-02 JP JP2023553065A patent/JP2024510935A/ja active Pending
- 2022-03-02 IL IL305495A patent/IL305495A/en unknown
- 2022-03-02 KR KR1020237032893A patent/KR20230152095A/ko unknown
- 2022-03-02 CN CN202280027156.1A patent/CN117120051A/zh active Pending
- 2022-03-02 AU AU2022228569A patent/AU2022228569A1/en active Pending
- 2022-03-02 BR BR112023017612A patent/BR112023017612A2/pt unknown
- 2022-03-02 WO PCT/US2022/018575 patent/WO2022187403A1/fr active Application Filing
- 2022-03-02 PE PE2023002483A patent/PE20240097A1/es unknown
- 2022-03-02 MX MX2023010324A patent/MX2023010324A/es unknown
-
2023
- 2023-09-01 CL CL2023002601A patent/CL2023002601A1/es unknown
- 2023-09-26 CO CONC2023/0012684A patent/CO2023012684A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CO2023012684A2 (es) | 2023-10-19 |
| EP4301357A1 (fr) | 2024-01-10 |
| AU2022228569A1 (en) | 2023-10-12 |
| CN117120051A (zh) | 2023-11-24 |
| IL305495A (en) | 2023-10-01 |
| CA3212130A1 (fr) | 2022-09-09 |
| PE20240097A1 (es) | 2024-01-18 |
| MX2023010324A (es) | 2023-11-09 |
| CL2023002601A1 (es) | 2024-03-22 |
| US20240059682A1 (en) | 2024-02-22 |
| BR112023017612A2 (pt) | 2023-12-05 |
| WO2022187403A1 (fr) | 2022-09-09 |
| JP2024510935A (ja) | 2024-03-12 |
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