KR20230135855A - A cosmetic composition for improving skin trouble containing plant complex extract and synthetic peptide - Google Patents

Abstract

The present invention is a cosmetic composition for improving skin troubles containing a mixture of complex plant extracts and peptides, including 0.0500-1.3000% by weight of angelica root extract, 0.1000-1.300% by weight of root extract, 0.0500-1.0000% by weight of sesame extract, and 0.1000-1.5000% by weight of windbreak extract. , Injin mugwort extract 0.1000~1.300% by weight, goji berry extract 0.0500~1.5000% by weight, plant complex extract of licorice extract 0.0500~1.5000% by weight, palmitoyl pentapeptide-4 0.0002~0.0090% by weight, palmitoyl tetrapeptide-7 0.0050~0. 1500 It contains a peptide mixture of 0.0002 to 0.0090% by weight of palmitoyl tripeptide-1 as an active ingredient, and has whitening effect, skin wrinkle improvement, skin elasticity improvement, skin regeneration, skin soothing effect, skin trouble improvement, moisturizing and oxidation effect. Excellent.

Description

Cosmetic composition for improving skin trouble containing plant complex extract and peptide mixture {A cosmetic composition for improving skin trouble containing plant complex extract and synthetic peptide}

The present invention relates to a cosmetic composition for improving skin troubles containing a complex plant extract and a peptide mixture. More specifically, it relates to a cosmetic composition containing a complex plant extract and a peptide mixture for whitening effect, skin wrinkle improvement, skin elasticity enhancement, skin regeneration, and skin soothing. It relates to a cosmetic composition for improving skin troubles containing a mixture of complex plant extracts and peptides that have effects, skin trouble improvement, moisturizing and oxidation properties.

Recently, interest in skin beauty and skin care is increasing due to the improvement in living standards, and to meet the preferences of various consumers, lotions (skin), lotions, essences, moisture creams, oil creams, eye creams, neck creams, lip creams, Cosmetics manufactured in various formulations, such as face balm, are being sold on the market, and trends in the cosmetics industry are also rapidly changing every year.

A variety of cosmetic raw materials are being developed to improve skin moisturization and loss of skin elasticity. However, in the recent environment, the use of animal raw materials has drastically decreased due to the decline in consumer preference for animal raw materials and the spread of mad cow disease, and the use of natural plant-based raw materials has decreased rapidly. Raw materials, namely plant extracts, are in the spotlight.

Looking at the prior art regarding cosmetic compositions containing the above plant extracts, Republic of Korea Patent No. 10-0525994, Cosmetic Composition Containing Bokbang Herbal Medicine Extract (announced on November 8, 2005), contains pomegranate peel, fennel, fennel, fennel and white paper. Disclosed is a cosmetic composition containing a bokbang herbal extract composed of mixed herbal medicines, which has the effect of improving fine wrinkles on the skin, scavenging harmful oxygen radicals (SUPEROXIDE RADICAL), and inhibiting the synthesis of collagen degrading enzyme (MATRIX METALLOPROTEASE-1). , Republic of Korea Patent No. 10-0669361 Cosmetic composition containing Jeolgukdae extract (announced on January 16, 2007) is a cosmetic composition containing Jeolgukdae extract and is a functional cosmetic composition with skin whitening effect, wrinkle improvement effect, and irritation relief effect. is starting.

The above conventional technologies can be expected to have an effect of maintaining skin moisture and supplying nutrition when a certain amount is consistently applied to the skin to prevent skin aging, but the problem is that the effects of improving skin trouble, preventing skin aging, and improving wrinkles are insufficient. there is.

The present invention was devised to solve the problems of the prior art, and is a plant complex extract consisting of angelica root extract, root extract, sesin extract, windbreak extract, mugwort extract, goji berry extract, licorice extract, palmitoyl pentapeptide-4, and palmitoyl pentapeptide-4. Cosmetic that contains a peptide mixture of toyl tetrapeptide-7 and palmitoyl tripeptide-1 as an active ingredient and has whitening effects, skin wrinkle improvement, skin elasticity enhancement, skin regeneration, soothing effect, skin trouble improvement, moisturizing, and anti-oxidation effect. To provide a composition.

The cosmetic composition of the present invention contains plant complex extracts and peptide mixtures of angelica root, root root, sesin, windbreak, mugwort, goji berry, and licorice extract as active ingredients.

In addition, the plant complex extract of the present invention includes 0.0500-1.3000% by weight of angelica root extract, 0.1000-1.300% by weight of root extract, 0.0500-1.0000% by weight of sesame extract, 0.1000-1.5000% by weight of windpipe extract, 0.1000-1.300% by weight of mugwort extract, and Goji berry extract. Contains 0.0500~1.5000% by weight, licorice extract 0.0500~1.5000% by weight.

In addition, the teptide mixture of the present invention includes 0.0002 to 0.0090% by weight of palmitoyl pentapeptide-4, 0.0050 to 0.1500% by weight of palmitoyl tetrapeptide-7, and 0.0002 to 0.0090% by weight of palmitoyl tripeptide-1.

In addition, the plant complex extract and peptide mixture of the present invention has a whitening effect, skin wrinkle improvement, skin elasticity improvement, skin regeneration, skin soothing effect, skin trouble improvement, moisturizing, and oxidation.

The cosmetic composition according to the present invention includes angelica root extract, root extract, sesin extract, windpipe extract, mugwort extract, goji berry extract, licorice extract and peptides of palmitoyl pentapeptide-4, palmitoyl tetrapeptide-7, and palmitoyl tripeptide-1. Containing the mixture as an active ingredient, it has excellent whitening effects, skin wrinkle improvement, skin elasticity enhancement, skin regeneration, skin soothing effect, skin trouble improvement, moisturizing, and oxidation effect.

In addition, the cosmetic composition according to the present invention has the effect of showing good medicinal efficacy by harmonizing the toxicity of the plant extract with licorice and eliminating it.

In addition, the present invention has the effect of not causing side effects even when applied to the skin due to the plant extract.

In general, cosmetics are products used to protect the skin, beautify and clean the skin, but in order to provide efficacy and effectiveness, they contain a number of ingredients that are different from the purpose of skin protection, such as fragrances, pigments, sunscreens, preservatives, and surfactants. inevitably included.

Many of the above ingredients are generally known to cause various skin problems such as inflammation, rashes, and edema. In addition, sebum and sweat discharged from the body, fatty acids, higher alcohols, and protein components in cosmetic ingredients are decomposed into highly toxic substances by skin flora existing on the skin, which may cause skin inflammation. It is well known that ultraviolet rays from the sun also cause skin inflammation. The inflammation is the body's immune response to wounds or diseases, and oxidative stress such as ultraviolet rays, active oxygen, and free radicals activate inflammatory factors, causing various diseases and skin aging.

Meanwhile, substances that act to eliminate inflammation by removing inflammatory sources and reducing biological reactions and symptoms are called anti-inflammatory agents. Substances currently used for anti-inflammatory purposes include non-steroids such as flufenamic acid, ibuprofen, benzydamine, and indomethacin, and steroids such as prednisolone. There are prednisolone and dexamethasone, but the amount of these substances is limited due to safety issues on the skin, so there is a limit to their use in cosmetics.

The cosmetic composition of the present invention can be prepared in the form of a general emulsified formulation and solubilized formulation. Cosmetics in emulsified formulations include nourishing lotions, creams, and essences, and cosmetics in solubilized formulations include flexible lotions.

The cosmetic composition of the present invention contains, in addition to the plant complex extract and peptide mixture, fatty substances, organic solvents, solubilizers, thickening and gelling agents, softeners, antioxidants, suspending agents, stabilizers, foaming agents, fragrances, surfactants, Commonly used in water, ionic or non-ionic emulsifiers, fillers, sequestering and chelating agents, preservatives, vitamins, blocking agents, wetting agents, essential oils, dyes, pigments, hydrophilic or lipophilic actives, lipid vesicles or in cosmetics. It may contain adjuvants such as any other ingredients.

The formulation of the cosmetic composition of the present invention is not limited, but includes skin lotion, skin softener, skin toner, astringent, lotion, milk lotion, moisture lotion, nutritional lotion, massage cream, nutritional cream, moisture cream, hand cream, essence, Any one formulation selected from the group consisting of packs including mask packs, soap, shampoo, cleansing foam, cleansing lotion, cleansing cream, cleansing oil, cleansing water, body lotion, body cleanser, emulsion, press powder, loose powder, and eye shadow. It can be applied.

According to China's oldest medicinal book, 'Shennong Herbal Medicine Classic' and the world-famous book on herbal medicine, 'Benchao Gangmu', written by Li Shi-jin, a famous pharmacist during the Ming Dynasty in China, Carefully selected plants were used as plant extracts of the present invention among medicinal herbs that are harmless and are said to be consumed by people who wish to achieve immortality, longevity, and lighten the body and add energy.

The present invention is a cosmetic composition used in cosmetics that is safe for use on the skin, is non-toxic, can improve skin troubles, provides anti-inflammatory properties, and is harmless to the human body by utilizing plant extracts existing in plants, that is, extracts of herbal medicine. It is a cosmetic composition that has no side effects on the skin. The plants, that is, herbal medicines, used in the cosmetic composition for improving skin troubles of the present invention are angelica root, wonji, sesin, bangpung, mugwort, goji berry, and licorice. The present invention contains a plant complex extract and a peptide mixture as active ingredients, and the plant complex extract includes angelica root extract, root extract, sesin extract, windpipe extract, mugwort extract, goji berry extract, and licorice extract as active ingredients.

The present invention utilizes the different efficacy and physical properties of angelica root, wonji, sesin, windbreak, mugwort, goji berry, licorice, and palmitoyl pentapeptide-4, palmitoyl tetrapeptide-7, and palmitoyl tripeptide-1 in an appropriate ratio. By mixing, it improves whitening effect, skin wrinkle improvement, skin elasticity improvement, skin regeneration, skin soothing effect, skin trouble improvement, moisturizing, and oxidation.

The angelica root extract consists of 0.0500 to 1.3000% by weight of the cosmetic composition. The angelica root is used in oriental medicine to treat blood pressure, blood pressure, and landscaping. It has effects such as anti-spasmodics, replenishes blood, clears heat, improves blood flow, and is used for diseases such as physical weakness, joint pain, headache, dizziness, abdominal pain, constipation, and bruises. Decursin, decursinol (decursinol), decusinol angelate, nodakenin, alpha-pinene, beta-sitosterol, umbelliferon, limonen, Contains elemol, etc.

If the angelica root extract is less than 0.0500% by weight, the effective ingredient causes little change in blood flow within the capillaries of the skin, reducing the effect of skin regeneration. If it exceeds 1.3000% by weight, the skin regeneration effect can no longer be expected, making it uneconomical. A problem arises. The Angelica uses the roots of Angelica, a 2-3 year old herbaceous plant belonging to the Apiaceae family and has a height of 60 to 90 cm. The flowers are white and bloom at the ends of the main stem and branches from August to September, and the fruits are flat, long oval shaped and have narrow wings on the edges.

The raw material extract constitutes 0.1000 to 1.300% by weight of the cosmetic composition. The above-mentioned root is a perennial herb belonging to the order Arborvitae. In oriental medicine, the root part is used for medicinal purposes, and has effects such as sedative, hypnotic, cardiotonic, phlegm-reducing, and hemolytic effects. If the base extract is less than 0.1000% by weight, the effective ingredient is so small that the effect of suppressing the formation of boils is reduced. If it exceeds 1.3000% by weight, the effect of inhibiting the formation of flakes is large, but uneconomical problems arise.

The leaves of the above-mentioned plant are alternate and needle-shaped, and the flowers are purple and grow sparsely in racemes at the ends of stems and branches from July to August. The petals are butterfly-shaped, the upper part is open and attached at the bottom, and the lower one is split at the end. . There are 8 stamens and the lower parts are combined. The fruit of the plant is a capsule that is flat and split into two, has many hairs on the seed, and its main ingredients include Saponin, Onjisaponin A-G, Tenuifolin, Xanthones, and 2,6,7,8-tetra. Methoxyxanthone (2,6,7,8-Tetramethoxyxanthone), 3-Hydroxy-2,6,7,8-Tetramethoxy polygalitol, etc. It contains this.

The sesin extract consists of 0.0500 to 1.0000% by weight of the cosmetic composition. The above-mentioned sesin is a herbal medicine made by drying the roots of the perennial plants belonging to the rattle vine family, such as the root of the plant and the plant of the chinensis. If the sesin extract is less than 0.0500% by weight, the effective ingredient is so small that the allergy suppressing effect is reduced, and if it exceeds 1.0000% by weight, the anti-allergy effect is great, but uneconomical problems arise.

The plant grows in shady wetlands deep in the mountains, and Seshin digs up the roots of the plant from spring to summer, washes them thoroughly in water, and dries them in the shade. The taste is spicy and the weakness is mild. The above-mentioned Sesin is effective in treating colds, cold, cold, headache, stuffy nose, fever, phlegm, cough, laryngitis, rhinitis, bronchitis, fever, anti-allergy, and germ inhibition.

The windbreak extract constitutes 0.1000 to 1.5000% by weight of the cosmetic composition. The root of the above windbreak has antipyretic properties. It has a pain-relieving pharmacological effect, so it is dried and used as a medicine. Its medicinal properties are mild and non-toxic, and its taste is spicy and sweet. The above windbreak is used when there is pain all over the body due to a cold, especially when there is severe pain in joints and muscles. It lowers fever and induces sweat to relieve pain, and is effective for people who have migraines and feel dizzy due to a weak constitution. It is effective in skin diseases such as eczema. If the amount of the windbreak extract is less than 0.1000% by weight, the effective ingredient is so small that the soothing effect on skin diseases and eczema is insufficient. If it exceeds 1.5000% by weight, the effect on eczema is great, but uneconomical problems arise.

The windbreak grows to a height of about 1 m in a dry sandy grass field, has many branches, blooms and withers three years after sprouting from the seed, produces many leaves from the roots, the leaves on the stem are alternate, and the petioles are upward. It gets shorter and shorter, and the lower part becomes a leaf sheath and splits into pinnate shapes three times. The flowers bloom in white from July to August, and the fruit is a meristematic fruit that is flat and wide oval-shaped and has protrusions when young.

The mugwort extract constitutes 0.1000 to 1.300% by weight of the cosmetic composition. The above Injin mugwort is Artemisia capillaris Thunb, which grows wild in various parts of Korea. Its young stems and leaves are called Injinho (茵陳蒿), and the young shoots are edible. In oriental medicine, it is also called Injinho (茵蔯蒿), and has diuretic, phlegm, and antipyretic properties. It is effective in treating jaundice, hepatitis, food poisoning, nephritis, etc. and has a whitening effect. Its ingredients include Scoparone, Chlorogenic acid, and Capillin.

If the mugwort extract is less than 0.1000% by weight, the active ingredient is so small that the whitening effect is reduced, and if it exceeds 1.300% by weight, no further whitening effect can be expected, resulting in an uneconomical problem. The above-mentioned mugwort is a perennial herb of the Campanula Asteraceae family. The lower part of the stem is lignified and becomes a semi-shrub. The stem on which flowers are hung is short, and the leaves on the upper part are clustered together to form a rosette. The stem on which flowers are hung is 0.3 to 1 m and is well branched. The leaves are all deeply split once or twice in the shape of pinnates, and the flowers bloom in large cone-shaped heads from August to September, becoming increasingly dense.

The goji berry extract consists of 0.0500 to 1.5000% by weight of the cosmetic composition. The wolfberry is a fruit of the wolfberry tree and contains various functional ingredients such as betaine, cholin, physalien, rutin, beta-sitosterol, and zeaxanthin. It has various physiological activities, including antioxidant effects, antibacterial and anticancer effects, immune-boosting effects, liver function improvement effects, and blood cholesterol-lowering effects. If the Goji berry extract is less than 0.0500% by weight, the active ingredient is so small that the sulfation and anti-inflammatory effects are reduced, and if it exceeds 1.5000% by weight, the sulfation and anti-inflammatory effects can no longer be expected, causing an uneconomical problem.

The Goji berry is a deciduous broad-leaved shrub whose stem is usually about 1 to 1.5 m long, has thorns at the leaf axils and ends of branches, has hairless leaves that are alternate, and grows in clusters, and purple flowers bloom in the axils of the leaves from June to September. 1 to 4 bloom. The goji berry fruit is round or oval in shape, has flesh, a lot of water, seeds, and ripens red. The length is 10 mm and the diameter is about 5 mm. It is sweet at first, but later tastes bitter. When dried, the outside is wrinkled, and the inside contains many seeds. It is cold (sometimes called flat) and has a bitter (sometimes sweet) taste. ) There is no poison.

In Oriental medicine, there are innate and acquired qualities, and among acquired qualities, there are yang and yin. Yang is in the form of energy, and yin represents blood and essence in the form of blood. It is known that when the balance of yang and yin is lost, the posterior qi is depleted and the innate qi is destroyed, causing disease or aging. Therefore, medicinal herbs with yang and yin energy corresponding to the acquired qi should be appropriately mixed in the skin. I do not want to take a scientific approach to the efficacy of medicinal herbs that maintain the balance of yang and yin.

The angelica root, root root, sesin, bangpung, mugwort, and wolfberry have their own properties as herbal medicines, but when used as a mixed extract rather than as a single extract, the efficacy increases and the overall efficacy can be achieved. However, due to their respective properties, herbal medicines have a mutualistic herbal composition that maximizes efficacy and reduces toxicity when used mixed, while herbal medicines have opposing compositions that reduce efficacy and increase toxicity when used mixed. Due to its composition, great caution is required when using herbal medicines with high medicinal efficacy.

The licorice extract neutralizes and harmonizes the respective effects of Angelica root, Angelica root, Sesin, Bangpung, Injin mugwort, and Goji berry, which are extracted from complex plant extracts, and provides a detoxifying effect while providing a soothing effect on skin diseases and eczema. The licorice extract constitutes 0.0500 to 1.5000% by weight of the cosmetic composition. The licorice harmonizes the toxicity of all medicines to ensure effective medicine, controls heat and morale in the intestines, improves communication in all blood vessels, strengthens muscles and bones, and has pharmacological effects such as detoxification, hepatitis, urticaria, eczema, anti-inflammatory, It has excellent pharmacological effects such as anti-allergy and antibacterial properties, and the physiologically active components of licorice include triterpene saponin, glycyrrhizin, which has a growth-inhibiting effect on bacteria and fungi, and flavonoid and manikin, which have antibacterial properties. Contains ingredients such as mannitol.

If the licorice extract is less than 0.0500% by weight, the active ingredient is so small that the detoxification and whitening effect and soothing effect on skin diseases and eczema are insufficient. If it exceeds 1.5000% by weight, the extract no longer has a detoxifying and whitening effect and soothing effect on skin diseases and eczema. Uneconomical problems arise as effects cannot be expected.

The licorice is a perennial herbaceous plant belonging to the legume family and is used by drying the leaves, roots, or stems. The outer skin is reddish brown or dark brown, has vertical wrinkles, and sometimes has sheaths, buds, and scale leaves attached. Peeled licorice has a light yellow outer surface and has a skin whitening function as it has an excellent effect in suppressing the deposition of melanin, a skin pigment that causes skin darkening, freckles, and freckles.

The licorice plant has reddish-brown roots that go deep into the ground, stems that are angular, and grow straight up to about 1m. It has dense white hairs, looks grayish-white, and has scattered glandular spots. Purple flowers bloom in July and August, and pods are thin like lines. It is long, curved like a bow, and contains 6 to 8 kidney-shaped seeds. The roots are sweet, so they are used as a sweetener and herbal medicine.

Peptides are polymers of amino acids, in which a small number of amino acids are linked together. They play a role in building a protein layer and help prevent skin aging and improve wrinkles. There are two types: natural and synthetic. The peptide mixture consists of 0.0054 to 0.0090% by weight of the composition. Among the peptides, when used in skin care, palmitoyl penta improves skin wrinkles, improves skin elasticity, skin regeneration, relieves skin irritation and has a soothing effect, has a great moisturizing effect, and has antioxidant activity. Includes Palmitoyl Pentapeptide-4, Palmitoyl Tetrapeptide-7, and Palmitoyl Tripeptide-1.

The palmitoyl pentapeptide-4 constitutes 0.0002 to 0.0090% by weight of the cosmetic composition. If the palmitoyl pentapeptide-4 is less than 0.0002% by weight, the active ingredient is minimal and recovery of damaged skin is not good. If it exceeds 0.0090% by weight, moisturizing and recovery of damaged skin are good, but the active ingredient is more than necessary, making it uneconomical. A problem arises.

The Palmitoyl Pentapeptide-4 is a peptide ingredient commercialized as Matrixyl derived from Matrikine, which is naturally produced to induce tissue regeneration when the skin is damaged. It improves skin elasticity by inducing the biosynthesis of collagen type I, restores skin damaged by external irritants including ultraviolet rays, and has an excellent moisturizing effect due to its good affinity for moisture.

The palmitoyl pentapeptide-4 is an epithelial cell growth factor that stimulates the synthesis of collagen and glycosaminoglycan, thereby increasing the activity of skin cells, which can be of great help in removing and preventing roughness and wrinkles in the skin and reducing the thickness of the skin. It is an ingredient that increases. In addition, it promotes the synthesis of hyaluronic acid in the skin to control moisture and prevent skin drying. It has an efficient ability to restore skin damaged by ultraviolet rays and external stimuli, and has no skin irritation or side effects.

The palmitoyl tetrapeptide-7 constitutes 0.0050 to 0.1500% by weight of the cosmetic composition. If the palmitoyl tetrapeptide-7 is less than 0.0050% by weight, the active ingredient is so small that recovery of damaged skin is not good. If it exceeds 0.1500% by weight, recovery of damaged skin is good, but the active ingredient is more than necessary, making it uneconomical. occurs.

The Palmitoyl Tetrapeptide-7 is a reaction product of palmitic acid and is a peptide containing glycine, glutamine, proline, and arginine. . The palmitoyl tetrapeptide-7 protects the skin from dryness and external stimulation, reduces the production of interleukin-6 (IL-6) by skin cells, keratinocytes and fibroblasts, and reduces skin aging and skin elasticity. It reduces substances that cause skin irritation and helps promote skin regeneration, improving fine wrinkles and increasing skin elasticity.

The palmitoyl tripeptide-1 constitutes 0.0002 to 0.0090% by weight of the cosmetic composition. If the palmitoyl tripeptide-1 is less than 0.0002% by weight, the active ingredient is so small that the improvement of wrinkles and skin elasticity is not good. If it exceeds 0.0090% by weight, the improvement of wrinkles and skin elasticity is good, but the active ingredient is used more than necessary. In many cases, non-economic problems arise.

Palmitoyl Tripeptide-1 is a neurotransmitter peptide component that maintains skin homeostasis and inhibits the activity of neurotransmitters released due to stimulation from various mechanical stresses, including ultraviolet rays, thereby reducing neurogenic inflammation. It relieves redness, swelling, and pain, which are reactions, and strengthens the skin's self-protection and recovery functions.

The palmitoyl tripeptide-1 is an amino acid sequence attached to palmitic acid and is absorbed deep into the skin. When used in cosmetics, it helps collagen synthesis, protects the skin from dryness and external stimulation, and improves skin texture. It helps increase skin elasticity and reduce wrinkles, and is an ingredient that has been certified as safe as EWG grade 1 (green grade). It is a good ingredient for skin care through mastication.

The peptide mixture may further include Copper Tripeptide-1 and Acetyl Hexapeptide-8. The copper tripeptide-1 consists of 0.0150 to 0.1100% by weight of the cosmetic composition, and acetylhexapeptide-8 consists of 0.0002 to 0.0100% by weight of the cosmetic composition.

If the copper tripeptide-1 is less than 0.01500% by weight, the active ingredient is so small that wrinkle improvement and moisture retention of the skin are not good, and if it exceeds 0.1100% by weight, further anti-inflammatory and antioxidant phenomena occur.

Copper Tripeptide-1 is a signal peptide that stimulates the synthesis of collagen III and promotes the synthesis and decomposition of glycosaminoglycan (GAG), a component naturally present in the body. It is a signal peptide that stimulates the synthesis and decomposition of glycosaminoglycan (GAG). It exerts immediate regenerative and anti-inflammatory effects on damage and wounds.

The copper tripeptide-1 acts as a growth factor for skin cells and stimulates the production of dermal components such as collagen synthesis and wound healing. In addition, it has an antioxidant function by suppressing free radicals that reduce skin elasticity and promote wrinkle formation, so it acts as a skin conditioning agent in cosmetics, improving skin wrinkles and promoting the synthesis of collagen, elastin, proteoglycan, glycosaminoglycan, etc. Prevents skin aging and skin moisture loss.

If the acetylhexapeptide-8 is less than 0.0002% by weight, the active ingredient is so small that the wrinkle improvement and anti-aging of the skin are not good, and if it exceeds 0.0100% by weight, skin elasticity increases more than necessary.

Acetyl Hexapeptide-8 is a cosmeceutical ingredient that has a low molecular structure, has excellent skin penetration, is quickly absorbed into the skin, has high stability, and does not cause toxic irritation to the skin, so it can replace or supplement Botox treatment. It is in the spotlight and is a non-toxic substance commonly called Botox peptide because the mechanism that regulates nerve transmission is similar to Botox protein. It is used as an alternative to cosmetics because there is no concern about side effects (allergic reaction, facial muscle paralysis, drooping eyelids) caused by other types of Botox ingredients. It is a substance that attracts attention.

The acetylhexapeptide-8 has structurally similar properties to a protein (SNAP-25) that stimulates muscles to release a neurotransmitter that creates wrinkles, and delays the formation of wrinkles and improves skin elasticity by regulating nerve responses to muscles. It has anti-wrinkle and anti-aging functions by increasing skin tone, and because it is a low-molecular peptide, it is easy to penetrate the skin.

The cosmetic composition contains 0.0500-1.3000% by weight of angelica root extract, 0.1000-1.300% by weight of root extract, 0.0500-1.0000% by weight of sesame extract, 0.1000-1.5000% by weight of windpipe extract, 0.1000-1.300% by weight of mugwort extract, and 0.0500-% of goji berry extract. 1.5000 weight %, 0.0500~1.5000% by weight of plant complex extract of licorice extract, 0.0002~0.0090% by weight of palmitoyl pentapeptide-4, 0.0050~0.1500% by weight of palmitoyl tetrapeptide-7, and 0.0002~0.0090% by weight of palmitoyl tripeptide-1. It is mixed with peptides and has the best whitening effect, skin wrinkle improvement, skin elasticity improvement, skin regeneration, skin soothing effect, skin trouble improvement, moisturizing and oxidation effect. Copper tripeptide-1 0.0150~0.1100% by weight, acetyl hexapeptide-1 8 If an additional 0.0002 to 0.0100% by weight is included, the wrinkle improvement and antioxidant effects become even better.

1. Preparation of plant complex extract

The Angelica root extract was obtained by adding 2,500g of purified water as an extraction solvent per 100g of dried Angelica root, boiling it in a bath at 65-80°C for 5-10 hours, extracting hot water, and then filtering it using filter paper in a filtration device. The raw paper extract was obtained by extracting 100g of the dried raw paper. Add 2,500 g of purified water as a sugar extraction solvent, heat water extract by boiling in a bath at 65-80°C for 5-10 hours, and then filter it using filter paper in a filtration device. The sesame extract is obtained by using 2,500 g of purified water as an extraction solvent per 100 g of dried sesin. After hot water extraction by boiling at 65-80°C for 5-15 hours, the extract is obtained by filtration using filter paper in a filtration device. The extract is obtained by adding 2,500 g of purified water as an extraction solvent per 100 g of dried bangpung, extracting it by cold immersion for 3 days, and then filtering. It is obtained by filtration using a filter paper in a device, and the mugwort extract is obtained by adding 7,000 g of purified water as an extraction solvent per 100 g of dried mugwort, boiling it in a bath at 65-80°C for 5-10 hours for hot water extraction, and then filtering it using filter paper in a filtration device. Goji berry extract was obtained by washing and chopping goji berry fruits, adding 5,000 g of purified water as an extraction solvent per 100 g of pulp, soaking and extracting for 5 days, maturing for 4 days, and filtering using filter paper in a filtration device, and the licorice extract was dried. After cutting the licorice into small pieces, 3,000 g of purified water was added as an extraction solvent per 100 g of licorice, immersion extracted for 7 days, aged for 4 days, and filtered using filter paper in a filtration device. The peptide component used in the peptide mixture was palmitoyl pentapeptide- 4 was purchased from Sederma, Inc., France, and palmitoyltetrapeptide-7 was purchased from Pentapharm, Inc., Switzerland. and palmitoyl tripeptide-1 from DSM, Inc. of Switzerland, copper tripeptide-1 from INKOS C0, Ltd. of Korea, and acetylhexapeptide-8 from Lipotec, Inc. of Spain.

2. Preparation of cosmetic composition

Cosmetic compositions according to Examples and Comparative Examples were prepared with the compositions shown in Table 1.

ingredient Content (% by weight) INCI Name(Korean) INCI Name (English) Example 1 Example 2 Example 3 Comparative example Butylene glycol Butylene Glycol 2.0000 2.0000 2.0000 2.0000 1,2-hexanediol 1,2-Hexanediol 1.0200 1.0200 1.0200 1.0200 Dipropylene glycol Dipropylene Glycol 2.5000 2.5000 2.5000 2.5000 glycerin Glycerin 0.2000 0.2000 0.2000 0.2000 Tromethamine Tromethamine 0.2000 0.2000 0.2000 0.2000 Adenosine Adenosine O.010O O.010O O.010O O.010O Sodium Hyaluronate Sodium Hyaluronate 0.0500 0.0500 0.0500 0.0500 caprylyl glycol Caprylyl Glycol 0.1000 0.1000 0.1000 0.1000 Ethylhexylglycerin Ethylhexylglycerin 0.0500 0.0500 0.0500 0.0500 Angelica root extract Angelica Gigas Root Extract 0.2500 0.7000 1.1000 - root extract Polygala Tenuifolia Root Extract 0.3000 0.7000 1.1000 - sesin extract Asarum Sieboldii Root Extract 0.2000 0.5500 0.9000 - windbreak extract Saposhnikovia Divaricata Root Extract 0.3000 0.8000 1.3000 - Injin mugwort extract Artemisia Capillaris Extract 0.3000 0.7000 1.1000 - Goji berry extract Lycium Chinense Fruit Extract 0.3000 0.8000 1.3000 - Licorice Extract Glycyrrhiza Uralensis (Licorice) Root Extract 0.3000 0.8000 1.3000 - Palmitoyl Pentapeptide-4 Palmitoyl Pentapeptide-4 0.0003 0.0045 0.0080 - Palmitoyl tetrapeptide-7 Palmitoyl Tetrapeptide-7 0.0060 0.0775 0.1300 - Palmitoyl Tripeptide-1 Palmitoyl Tripeptide-1 0.0003 0.0045 0.0080 - Copper Tripeptide-1 Copper Tripeptide-1 0.0300 0.0625 0.0900 0.0625 Acetylhexapeptide-8 Acetyl Hexapeptide-8 0.0003 0.0050 0.0090 0.0050 Purified water Water Remaining amount Remaining amount Remaining amount Remaining amount

Experiment 1: Whitening effect

The whitening effect of the plant complex extract of the present invention was measured on 70 women aged 25 to 60 (average age 38). First, divide into 7 groups of 10 people per group (2 groups for each example and comparative example), attach an opaque tape with 5 holes with a diameter of 1.5 cm to the lower part of each arm, and apply approximately twice the minimum amount of erythema for each subject. After inducing darkening of the skin by irradiating ultraviolet rays (UVB), the Examples were applied twice a day, 7 days a week, for 4 weeks. The L*a*b* colorimetric system is used to display color, and in this experiment, the L* (brightness) value was mainly used as an indicator. The whitening effect was measured by calculating the difference in skin color (ΔL*) between the start of applying each composition and the completion of each composition one month later using the following equation, and a commercially available mud pack was used as a comparative example. The results of the whitening effect of the cosmetic composition of the present invention are shown in Table 2.

(ΔL* = L* value after application - L* value at start of application)

division ΔL* Example 1 group 1 1.53 group 2 1.60 Example 2 group 3 1.72 group 4 1.83 Example 3 group 5 1.88 group 6 1.81 Comparative example 0.87

It can be confirmed that the cosmetic composition of the plant complex extract of the present invention reduces skin pigmentation and has an excellent whitening effect compared to the comparative example.

Experiment 2: Skin wrinkle improvement effect

The skin wrinkle improvement effect of the cosmetic composition of the present invention was measured on 70 healthy women aged 35 to 50 (average age 42 years). First, 10 people per group were divided into 7 groups (2 groups for each example and comparative example), and the cosmetic compositions of each example and comparative example were applied to the face twice a day (morning/evening) for 3 months to improve wrinkles after 3 months. The degree was evaluated through subject questionnaires and image analysis of wrinkles.

The subject's questionnaire was judged into four levels: no improvement, slight improvement, moderate improvement, and significant improvement compared to before use. The experimental results of the skin wrinkle improvement effect of the cosmetic composition of the present invention are shown in Table 3.

division no improvement slight improvement Moderate improvement significant improvement Example 1 group 1 2 4 3 One group 2 2 3 4 One Example 2 group 3 2 2 3 3 group 4 One 4 3 2 Example 3 group 5 0 2 4 4 group 6 0 2 6 2 Comparative example 5 5 - -

It can be confirmed that the cosmetic composition of the present invention has an excellent skin wrinkle improvement effect compared to the comparative example.

Experiment 3: Skin elasticity improvement effect

The skin elasticity improvement effect of the cosmetic composition of the present invention was measured on 70 healthy women aged 25 to 60 (average age 35). First, 10 people per group were divided into 7 groups (2 groups for each example and comparative example), and the cosmetic compositions of each example and comparative example were applied around the eyes twice a day (in the morning) under conditions of 24-26°C and 75% humidity. /evening) After application for 3 months, skin elasticity was measured using a skin elasticity meter (Cutometer MPA580, Conrage + Khazaka, Germany). The test results were reported as the R5 (R5 (12 weeks) - R5 (0 weeks)) value of the Cutometer MPA580. The R5 value represents the net elasticity of the skin, and the closer it is to 1, the better the elasticity. The experimental results of the skin elasticity improvement effect of the cosmetic composition of the present invention are shown in Table 4.

division Skin elasticity improvement effect Increase rate (%) Example 1 group 1 0.081 252 group 2 0.084 265 Example 2 group 3 0.090 291 group 4 0.085 269 Example 3 group 5 0.077 234 group 6 0.071 208 Comparative example 0.023 -

It can be confirmed that the cosmetic composition of the present invention has an excellent skin elasticity improvement effect compared to the comparative example.

Experiment 4: Cell regeneration effect

The cell regenerative effect of the plant complex extract of the present invention was confirmed by performing a wound healing assay, and keratinocytes (HaCaT cells) were grown at 5 × 10 ⁵ cells/well using DMEM medium supplemented with 10% FBS. After adjustment, it was inoculated into a 6 well plate and cultured for 18 hours. The cells grown in a 6-well plate were scratched to cause some of the cells to fall off the bottom of the 6-well plate, and then the sample of the example was treated and cultured for 18 hours. The cell regeneration rate was calculated using the formula below, and no samples were treated in the control group. The results of the cell regeneration effect of the cosmetic composition of the present invention are shown in Table 5.

Cell renewal rate (%) = (sample cell renewal rate/control cell renewal rate) × 100

division Treatment concentration (W/V, %) Cell renewal rate (%) Example 1 0.5 82.7 Example 2 0.5 83.2 Example 3 0.5 88.5 Untreated control group - 48.4

It can be confirmed that the cosmetic composition of the present invention has an excellent cell regeneration effect compared to the untreated control group.

Experiment 5: Anti-inflammatory effect (skin trouble improvement effect)

The anti-inflammatory effect of the plant complex extract of the present invention was tested using carrageenan foot edema. In each example, 10-100 mg/kg was administered intraperitoneally to mice, and 1 hour later, 0.5 ml of 0.1% carrageenan solution was injected into the hind paws of experimental white mice to induce inflammation. The change in paw volume of the rat was measured immediately and 4 hours after the carrageenan injection, and the inhibition rate was calculated using the following formula. The results of the inhibition rate against inflammation of the cosmetic composition of the present invention are shown in Table 6.

Inhibition rate (%) = (1-ΔV treatment group/ΔV control group) × 100

ΔV: Change in foot volume

Dosage (mg) Inhibition rate (%) Example 1 Example 2 Example 3 Comparative example 10 21.4 26.0 31.8 16.0 50 36.7 31.5 48.9 27.2 100 43.7 51.6 54.4 33.8

It can be confirmed that the cosmetic composition of the present invention has an excellent anti-inflammatory effect (skin trouble improvement effect) compared to the comparative example.

Experiment 6: Moisturizing effect

The moisturizing effect of the cosmetic composition of the present invention was measured through a survey on 70 healthy women aged 35 to 60 (average age 48) who felt their skin was dry. First, 10 people per group were divided into 7 groups (2 groups for each example and comparative example), and the cosmetic compositions of each example and comparative example were applied to the face twice a day for 2 weeks, every 1 week from the start of the actual use test. And the improvement effect after completion was evaluated using Corneometer CM 820 (Corage +Khazaka, Germany). The experimental results of the moisturizing effect of the cosmetic composition of the present invention are shown in Table 7.

division Before use After 2 weeks of use After 4 weeks of use Example 1 group 1 22.6 36.0 46.7 group 2 22.5 38.8 45.3 Example 2 group 3 22.9 36.5 49.5 group 4 23.2 41.0 53.6 Example 3 group 5 22.9 35.7 51.4 group 6 24.4 44.2 55.8 Comparative example 22.6 26.4 30.1

It can be confirmed that the cosmetic composition of the present invention has an excellent moisturizing effect compared to the comparative example.

Experiment 7: Effect of sulfation

A free radical scavenging activity test was conducted to determine the antioxidant effect of the cosmetic composition of the present invention using a free radical reagent, DPPH (1,1-diphenyl-2-picryhydrazyl, Sigma). An experimental group was set up by adding and mixing 150 ㎕ of the example of the plant complex extract and peptide mixture composition to 150 ㎕ of 0.2mM DPPH solution (Blank is ethanol), leaving it at room temperature for 30 minutes, and measuring the absorbance at 517 nm. As a control group, purified water was used. After measuring the absorbance of the experimental group and the control group, it was substituted into "Free radical scavenging effect (%) = 100 - [(Experimental group absorbance - Blank absorbance) / Control group absorbance] × 100", and the free radical scavenging activity effect of the cosmetic composition of the present invention was calculated. The experimental results are shown in Table 8.

division Free radical scavenging effect (%) Example 1 36.7 Example 2 44.6 Example 3 66,4 Comparative example 21.9

It can be confirmed that the cosmetic composition of the present invention has excellent free radical scavenging ability compared to the comparative example.

The terms and words used in the specification and claims of the present invention are not to be construed as limited to their usual or dictionary meanings, and the inventor may appropriately define the concept of terms in order to explain his or her invention in the best way. Based on this, it should be interpreted as meaning and concept consistent with the technical idea of the present invention.

Therefore, the embodiments described in the detailed description of the present invention and the configuration shown in the drawings are only the most preferred embodiments of the present invention, so the scope of the present invention should not be limited to the described embodiments and should not be limited to the present invention at the time of filing. It should be understood that variations are possible or may exist and should be determined by the scope of the patent claims and their equivalents.

Claims (8)

A cosmetic composition for improving skin troubles containing a plant complex extract and a peptide mixture, characterized in that it contains a plant complex extract and a peptide mixture consisting of angelica root, wonji, sesin, bangpung, mugwort, goji berry, and licorice extracts as active ingredients.
According to paragraph 1,
The plant complex extract includes 0.0500-1.3000% by weight of angelica root extract, 0.1000-1.300% by weight of root extract, 0.0500-1.0000% by weight of sesame extract, 0.1000-1.5000% by weight of windpipe extract, 0.1000-1.300% by weight of mugwort extract, and 0.0500% by weight of goji berry extract. ~1.5000 A cosmetic composition for improving skin troubles containing a mixture of plant complex extracts and peptides, characterized in that it contains 0.0500 to 1.5000% by weight of licorice extract.
According to paragraph 2,
The teptide mixture is a plant complex extract comprising 0.0002 to 0.0090% by weight of palmitoyl pentapeptide-4, 0.0050 to 0.1500% by weight of palmitoyl tetrapeptide-7, and 0.0002 to 0.0090% by weight of palmitoyl tripeptide-1. A cosmetic composition for improving skin troubles containing a mixture of and peptides.
According to paragraph 3,
The cosmetic composition for improving skin troubles containing a mixture of plant complex extracts and peptides is a cosmetic composition for improving skin troubles containing a mixture of plant complex extracts and peptides, characterized in that it regenerates the skin.
According to paragraph 3,
A cosmetic composition for improving skin troubles containing a mixture of plant complex extracts and peptides, characterized in that the cosmetic composition for improving skin troubles has a whitening effect, improves skin elasticity, and improves skin wrinkles.
According to paragraph 3,
A cosmetic composition for improving skin troubles containing a complex plant extract and a peptide mixture, characterized in that the cosmetic composition for improving skin troubles containing a mixture of plant complex extracts and peptides is for improving skin troubles.
According to paragraph 3,
A cosmetic composition for improving skin troubles containing a complex plant extract and a peptide mixture, characterized in that the cosmetic composition for improving skin troubles containing a mixture of plant complex extracts and peptides is for moisturizing purposes.
According to paragraph 3,
A cosmetic composition for improving skin troubles containing a complex plant extract and a peptide mixture, characterized in that the cosmetic composition for improving skin troubles containing a mixture of plant complex extracts and peptides is for oxidation.