KR20230127254A - 치환된 거대고리 화합물 및 관련 치료방법 - Google Patents

치환된 거대고리 화합물 및 관련 치료방법 Download PDF

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Publication number
KR20230127254A
KR20230127254A KR1020237024587A KR20237024587A KR20230127254A KR 20230127254 A KR20230127254 A KR 20230127254A KR 1020237024587 A KR1020237024587 A KR 1020237024587A KR 20237024587 A KR20237024587 A KR 20237024587A KR 20230127254 A KR20230127254 A KR 20230127254A
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South Korea
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formula
another embodiment
ring
alkyl
alkylene
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English (en)
Korean (ko)
Inventor
루이스 디. 페닝턴
최영기
호안 형
브라이언 엠. 아퀼라
잉고 머그
위안 후
제임스 알. 우즈
브라이언 케네스 레이머
요르그 마틴 벤지엔
조나단 워드 레만
마이클 알. 헤일
시리니바사 카라
로만 에이. 발리울린
달지트 마타루
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알케르메스,인코포레이티드
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Publication of KR20230127254A publication Critical patent/KR20230127254A/ko
Pending legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • A61P25/10Antiepileptics; Anticonvulsants for petit-mal
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
KR1020237024587A 2020-12-21 2021-12-21 치환된 거대고리 화합물 및 관련 치료방법 Pending KR20230127254A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063128404P 2020-12-21 2020-12-21
US63/128,404 2020-12-21
US202163190937P 2021-05-20 2021-05-20
US63/190,937 2021-05-20
PCT/US2021/064483 WO2022140316A1 (en) 2020-12-21 2021-12-21 Substituted macrocyclic compounds and related methods of treatment

Publications (1)

Publication Number Publication Date
KR20230127254A true KR20230127254A (ko) 2023-08-31

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KR1020237024587A Pending KR20230127254A (ko) 2020-12-21 2021-12-21 치환된 거대고리 화합물 및 관련 치료방법

Country Status (10)

Country Link
US (2) US12006330B2 (https=)
EP (1) EP4263555A1 (https=)
JP (1) JP2024501641A (https=)
KR (1) KR20230127254A (https=)
CN (1) CN116615427B (https=)
AU (1) AU2021409403A1 (https=)
CA (1) CA3172841A1 (https=)
IL (1) IL303848A (https=)
MX (1) MX2023005338A (https=)
WO (1) WO2022140316A1 (https=)

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Also Published As

Publication number Publication date
JP2024501641A (ja) 2024-01-15
US20240368182A1 (en) 2024-11-07
MX2023005338A (es) 2023-05-22
CN116615427A (zh) 2023-08-18
US12006330B2 (en) 2024-06-11
EP4263555A1 (en) 2023-10-25
CN116615427B (zh) 2025-07-04
IL303848A (en) 2023-08-01
AU2021409403A9 (en) 2025-03-20
US20220194958A1 (en) 2022-06-23
WO2022140316A1 (en) 2022-06-30
AU2021409403A1 (en) 2023-05-25
CA3172841A1 (en) 2022-06-30

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