KR20230116865A - 우울증의 치료를 위한 nr2b-nmda 수용체 nam의 투여요법 - Google Patents

우울증의 치료를 위한 nr2b-nmda 수용체 nam의 투여요법 Download PDF

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Publication number
KR20230116865A
KR20230116865A KR1020237021993A KR20237021993A KR20230116865A KR 20230116865 A KR20230116865 A KR 20230116865A KR 1020237021993 A KR1020237021993 A KR 1020237021993A KR 20237021993 A KR20237021993 A KR 20237021993A KR 20230116865 A KR20230116865 A KR 20230116865A
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KR
South Korea
Prior art keywords
compound
pharmaceutically acceptable
acceptable salt
treatment
patient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
KR1020237021993A
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English (en)
Korean (ko)
Inventor
장-호 차
토마스 폴러
발타자르 고메즈-만실라
디미트리스 파파니콜로
카르멘-가브리엘라 세르반
플로리앙 봉 레종
Original Assignee
노파르티스 아게
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 노파르티스 아게 filed Critical 노파르티스 아게
Publication of KR20230116865A publication Critical patent/KR20230116865A/ko
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020237021993A 2020-12-04 2021-12-03 우울증의 치료를 위한 nr2b-nmda 수용체 nam의 투여요법 Pending KR20230116865A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063121508P 2020-12-04 2020-12-04
US202063121513P 2020-12-04 2020-12-04
US63/121,513 2020-12-04
US63/121,508 2020-12-04
PCT/IB2021/061268 WO2022118264A1 (en) 2020-12-04 2021-12-03 Dosage regimen for a nr2b-nmda receptor nam for the treatment of depression

Publications (1)

Publication Number Publication Date
KR20230116865A true KR20230116865A (ko) 2023-08-04

Family

ID=78844691

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020237021993A Pending KR20230116865A (ko) 2020-12-04 2021-12-03 우울증의 치료를 위한 nr2b-nmda 수용체 nam의 투여요법

Country Status (10)

Country Link
US (1) US20240041853A1 (enExample)
EP (1) EP4255419A1 (enExample)
JP (1) JP2023551943A (enExample)
KR (1) KR20230116865A (enExample)
AU (1) AU2021390209A1 (enExample)
CA (1) CA3203144A1 (enExample)
IL (1) IL303357A (enExample)
MX (1) MX2023006567A (enExample)
TW (1) TW202237103A (enExample)
WO (1) WO2022118264A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119654149A (zh) * 2022-06-02 2025-03-18 诺华股份有限公司 用于在治疗抑郁障碍中使用的奥法地尔的皮下施用和给药方法
WO2025120013A1 (en) * 2023-12-06 2025-06-12 Novartis Ag Compositions and methods for treating depression disorders

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL145584A0 (en) * 2000-10-02 2002-06-30 Pfizer Prod Inc Nmda nr2b antagonists for treatment
US9540324B2 (en) * 2013-09-26 2017-01-10 Luc Therapeutics, Inc. Selective octahydro-cyclopenta[C] pyrrole negative modulators of NR2B
JO3579B1 (ar) * 2014-09-26 2020-07-05 Luc Therapeutics Inc مُعدِلات تفاغرية سالبة لمستقبل nr2b من المركب n-ألكيل أريل-5-أوكسي أريل-ثامن هيدرو-خماسي الحلقة [c] بيرول
CA2970958A1 (en) * 2014-12-23 2016-06-30 Cerecor, Inc. Compounds, compositions and methods
MX2018004256A (es) * 2015-10-14 2018-05-16 Squibb Bristol Myers Co Antagonistas de receptor de n-metil-d-aspartato subtipo 2b (nr2b) selectivos.
CA3001894A1 (en) * 2015-10-14 2017-04-20 Bristol-Myers Squibb Company Selective nr2b antagonists

Also Published As

Publication number Publication date
AU2021390209A1 (en) 2023-06-22
WO2022118264A1 (en) 2022-06-09
CA3203144A1 (en) 2022-06-09
US20240041853A1 (en) 2024-02-08
AU2021390209A9 (en) 2024-10-31
IL303357A (en) 2023-08-01
JP2023551943A (ja) 2023-12-13
MX2023006567A (es) 2023-06-16
EP4255419A1 (en) 2023-10-11
TW202237103A (zh) 2022-10-01

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Patent event date: 20230629

Patent event code: PA01051R01D

Comment text: International Patent Application

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Patent event code: PA02012R01D

Patent event date: 20241202

Comment text: Request for Examination of Application