KR20230093538A - 크론병과 연관된 tnfsf15와 dcr3의 변이체 - Google Patents

크론병과 연관된 tnfsf15와 dcr3의 변이체 Download PDF

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KR20230093538A
KR20230093538A KR1020237020524A KR20237020524A KR20230093538A KR 20230093538 A KR20230093538 A KR 20230093538A KR 1020237020524 A KR1020237020524 A KR 1020237020524A KR 20237020524 A KR20237020524 A KR 20237020524A KR 20230093538 A KR20230093538 A KR 20230093538A
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seq
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tnfsf15
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crohn
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더모트 피. 맥거번
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세다르스-신나이 메디칼 센터
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    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
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    • C12Q2600/172—Haplotypes

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KR1020237020524A 2013-05-17 2014-05-16 크론병과 연관된 tnfsf15와 dcr3의 변이체 Ceased KR20230093538A (ko)

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KR1020257028341A KR20250130857A (ko) 2013-05-17 2014-05-16 크론병과 연관된 tnfsf15와 dcr3의 변이체

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361824932P 2013-05-17 2013-05-17
US61/824,932 2013-05-17
PCT/US2014/038468 WO2014186750A2 (en) 2013-05-17 2014-05-16 Variants of tnfsf15 and dcr3 associated with crohn's disease
KR1020217026836A KR20210107176A (ko) 2013-05-17 2014-05-16 크론병과 연관된 tnfsf15와 dcr3의 변이체

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KR1020237020524A Ceased KR20230093538A (ko) 2013-05-17 2014-05-16 크론병과 연관된 tnfsf15와 dcr3의 변이체
KR1020217026836A Ceased KR20210107176A (ko) 2013-05-17 2014-05-16 크론병과 연관된 tnfsf15와 dcr3의 변이체
KR1020157034355A Active KR102295125B1 (ko) 2013-05-17 2014-05-16 크론병과 연관된 tnfsf15와 dcr3의 변이체
KR1020257028341A Pending KR20250130857A (ko) 2013-05-17 2014-05-16 크론병과 연관된 tnfsf15와 dcr3의 변이체

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KR1020157034355A Active KR102295125B1 (ko) 2013-05-17 2014-05-16 크론병과 연관된 tnfsf15와 dcr3의 변이체
KR1020257028341A Pending KR20250130857A (ko) 2013-05-17 2014-05-16 크론병과 연관된 tnfsf15와 dcr3의 변이체

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US (4) US20160090629A1 (cg-RX-API-DMAC7.html)
EP (3) EP3498867B1 (cg-RX-API-DMAC7.html)
JP (5) JP6482533B2 (cg-RX-API-DMAC7.html)
KR (4) KR20230093538A (cg-RX-API-DMAC7.html)
CN (1) CN105358713B (cg-RX-API-DMAC7.html)
ES (1) ES2894963T3 (cg-RX-API-DMAC7.html)
WO (1) WO2014186750A2 (cg-RX-API-DMAC7.html)

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US20110229471A1 (en) 2008-11-26 2011-09-22 Cedars-Sinai Medical Center Methods of determining responsiveness to anti-tnf alpha therapy in inflammatory bowel disease
JP2014531210A (ja) 2011-09-30 2014-11-27 テバ・ファーマシューティカルズ・オーストラリア・ピーティワイ・リミテッド ＴＬ１ａに対する抗体およびその使用
WO2014160883A1 (en) 2013-03-27 2014-10-02 Cedars-Sinai Medical Center Treating fibrosis and inflammation by inhibiting tl1a
EP3498867B1 (en) 2013-05-17 2021-09-29 Cedars-Sinai Medical Center Variants of tnfsf15 and dcr3 associated with crohn's disease
US10316083B2 (en) 2013-07-19 2019-06-11 Cedars-Sinai Medical Center Signature of TL1A (TNFSF15) signaling pathway
EP3337465B1 (en) 2015-08-21 2021-11-24 The Children's Hospital of Philadelphia Compositions and methods for use in combination for the treatment and diagnosis of autoimmune diseases
TWI703158B (zh) 2015-09-18 2020-09-01 美商希佛隆公司 特異性結合tl1a之抗體
KR20240095481A (ko) 2016-03-17 2024-06-25 세다르스-신나이 메디칼 센터 Rnaset2를 통한 염증성 장 질환의 진단 방법
EP3458466B1 (en) * 2016-05-20 2024-08-07 Cedars-Sinai Medical Center Diagnosis of inflammatory bowel disease based on genes
EP3846851A4 (en) * 2018-09-07 2022-09-21 The Children's Hospital Of Philadelphia COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING DISORDERS OF THE LYMPHATIC SYSTEM
KR20220088529A (ko) 2019-05-14 2022-06-27 프로메테우스 바이오사이언시즈, 인크. Tl1a 환자 선택 방법, 시스템 및 장치
BR112022004590A2 (pt) * 2019-09-13 2022-06-14 Kyowa Kirin Co Ltd Variante dcr3
PH12023500011A1 (en) * 2020-11-13 2024-03-11 Cedars Sinai Medical Center Methods, systems, and kits for treatment of inflammatory diseases targeting tl1a
WO2025038473A1 (en) 2023-08-11 2025-02-20 Paragon Therapeutics, Inc. Tl1a binding antibodies and methods of use

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US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US20090186034A1 (en) * 2006-12-19 2009-07-23 Genetech, Inc. Gene expression markers for inflammatory bowel disease
US20100190162A1 (en) 2007-02-26 2010-07-29 Cedars-Sinai Medical Center Methods of using single nucleotide polymorphisms in the tl1a gene to predict or diagnose inflammatory bowel disease
WO2009052512A2 (en) 2007-10-19 2009-04-23 Cedars-Sinai Medical Center Methods of using genetic variants to diagnose and predict inflammatory bowel disease
SI2257643T1 (sl) 2008-02-19 2018-12-31 The Children's Hospital Of Philadelphia Identifikacija predelov vnetne črevesne bolezni z začetkom v otroštvu in metode za njeno uporabo za diagnozo in zdravljenje te bolezni
WO2010118210A1 (en) * 2009-04-08 2010-10-14 Cedars-Sinai Medical Center Methods of predicting complication and surgery in crohn's disease
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DK2676137T3 (en) 2011-02-17 2015-01-19 Nestec Sa TESTS TO DETECT AUTO ANTIBODIES FOR ANTI-TNF PHARMACEUTICALS
WO2012161856A1 (en) * 2011-05-20 2012-11-29 Government Of The United States, As Represented By The Secretary, Department Of Health And Human Services Blockade of tl1a-dr3 interactions to ameliorate t cell mediated disease pathology and antibodies thereof
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EP3498867B1 (en) 2013-05-17 2021-09-29 Cedars-Sinai Medical Center Variants of tnfsf15 and dcr3 associated with crohn's disease
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KR20240095481A (ko) 2016-03-17 2024-06-25 세다르스-신나이 메디칼 센터 Rnaset2를 통한 염증성 장 질환의 진단 방법

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WO2014186750A3 (en) 2015-01-08
US20180230543A1 (en) 2018-08-16
EP2997165A4 (en) 2017-03-08
EP3988673A2 (en) 2022-04-27
KR20160009582A (ko) 2016-01-26
JP2022111329A (ja) 2022-07-29
US20250243548A1 (en) 2025-07-31
JP6482533B2 (ja) 2019-03-13
EP3498867B1 (en) 2021-09-29
KR20210107176A (ko) 2021-08-31
WO2014186750A2 (en) 2014-11-20
ES2894963T3 (es) 2022-02-16
EP3498867A1 (en) 2019-06-19
US20160090629A1 (en) 2016-03-31
JP2016526875A (ja) 2016-09-08
JP2018148931A (ja) 2018-09-27
ES2894963T8 (es) 2022-02-24
US12281359B2 (en) 2025-04-22
JP2025023316A (ja) 2025-02-14
EP3988673A3 (en) 2022-08-03
KR102295125B1 (ko) 2021-08-31
KR20250130857A (ko) 2025-09-02
JP2020127437A (ja) 2020-08-27
US20210371931A1 (en) 2021-12-02
EP2997165A2 (en) 2016-03-23
CN105358713A (zh) 2016-02-24
CN105358713B (zh) 2020-02-28

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