KR20230086663A - 대상체에서 생체분자를 발현하기 위한 시스템 및 방법 - Google Patents
대상체에서 생체분자를 발현하기 위한 시스템 및 방법 Download PDFInfo
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Abstract
본 발명은 대상체에서 적어도 하나의 치료 단백질 또는 생물학적 활성 핵산 분자를 발현하기 위한 조성물, 시스템, 키트 및 방법을 제공한다. 특정 구현양태에서, 대상체는 먼저 핵산 분자가 없거나 본질적으로 없는 다가양이온성 구조를 포함하는 조성물을 투여받고, 이어서(예를 들어, 1-30분 후) 적어도 하나의 치료 단백질(예를 들어, 적어도 하나의 항-SARS-CoV-2 항체, 다수의 상이한 항체, ACE2 단백질 또는 인간 성장 호르몬) 또는 생물학적 활성 핵산 분자를 암호화하는 다수의 하나 이상의 비-바이러스 발현 벡터를 포함하는 조성물을 투여받는다.
Description
본 출원은 2020년 9월 25일에 출원된 미국 가출원 일련 번호 63/083,625에 대한 우선권을 주장하며, 전체 내용이 참조로 본원에 포함된다.
서열 목록
2021년 9월 24일에 작성되고 파일 크기가 2,893,042바이트인 "38655-601_SEQUENCE_LISTING_ST25"라는 명칭으로 함께 제출된 컴퓨터 판독가능 서열 목록의 텍스트는 전체가 참조로 포함된다.
본 발명은 대상체에서 적어도 하나의 치료 단백질 또는 생물학적 활성 핵산 분자를 발현하기 위한 조성물, 시스템, 키트 및 방법을 제공한다. 특정 구현양태에서, 대상체는 먼저 핵산 분자가 없거나 또는 본질적으로 없는 다가양이온성 구조를 포함하는 조성물을 투여받고, 이어서(예를 들어, 1-30분 후) 적어도 하나의 치료 단백질(예를 들어, 적어도 하나의 항-SARS-CoV-2 항체, 다수의 상이한 항체, 하나의 항-SARS-CoV-2 재조합 ACE2 단백질, 적어도 하나의 사이토카인 또는 인간 성장 호르몬) 또는 생물학적 활성 핵산 분자를 암호화하는 다수의 하나 이상의 비-바이러스 발현 벡터를 포함하는 조성물을 투여받는다.
가장 단순한 비-바이러스 유전자 전달 시스템은 네이키드 발현 벡터 DNA를 사용한다. 유리 DNA를 특정 조직, 특히 근육에 직접 주입하면 높은 수준의 유전자 발현이 나타나는 것으로 나타났으며, 이 접근 방식의 단순성으로 인해 많은 임상 프로토콜에서 채택되었다. 특히, 이 접근법은 암 백신으로 기능할 수 있는 종양 항원을 발현하기 위해 DNA를 종양에 직접 주입하거나 근육 세포에 주입할 수 있는 암의 유전자 치료에 적용되었다.
플라스미드 DNA의 직접 주입이 유전자 발현을 유도하는 것으로 나타났지만, 전체적인 발현 수준은 바이러스 또는 리포좀 벡터를 사용하는 것보다 훨씬 낮다. 네이키드 DNA는 또한 일반적으로 혈청 뉴클레아제의 존재로 인해 전신 투여에 적합하지 않은 것으로 생각된다. 결과적으로, 플라스미드 DNA의 직접 주입은 피부 및 근육 세포와 같이 직접 주입이 쉽게 접근가능한 조직을 포함하는 소수의 적용에만 제한되는 것으로 보인다.
본 발명은 대상체에서 적어도 하나의 치료 단백질 또는 생물학적 활성 핵산 분자를 발현하기 위한 조성물, 시스템, 키트 및 방법을 제공한다. 특정 구현양태에서, 대상체는 먼저 핵산 분자가 없거나 또는 본질적으로 없는 다가양이온성 구조를 포함하는 조성물을 투여받고, 이어서(예를 들어, 1-30분 후), 적어도 하나의 치료 단백질(예를 들어, 적어도 하나의 항-SARS-CoV-2 항체, 다수의 상이한 항체, 또는 인간 성장 호르몬) 또는 생물학적 활성 핵산 분자를 암호화하는 다수의 하나 이상의 비-바이러스 발현 벡터를 포함하는 조성물을 투여받는다. 일부 구현양태에서, 대상체에게 발현 수준 및/또는 길이를 증가시키는 제제(예를 들어, EPA 또는 DHA)가 추가로 투여된다. 특정 구현양태에서, 제 1 및/또는 제 2 조성물은 대상체의 기도를 통해 투여된다.
일부 구현양태에서, 본원은 a) 다가양이온성 구조를 포함하고, 핵산 분자가 없거나 본질적으로 없는 제 1 조성물을 대상체에게 투여하는 단계; 및 b) 제 1 조성물을 투여한 후 대상체에게 적어도 하나의 항-SARS-CoV-2 항체 또는 이의 항원-결합 부분, 및/또는 재조합 ACE2를 암호화하는 다수의 하나 이상의 비-바이러스 발현 벡터를 포함하는 제 2 조성물을 투여하는 단계를 포함하는 방법을 제공하며, 여기서 제 1 및 제 2 조성물을 투여한 결과로서, 적어도 하나의 항-SARS-CoV-2 항체, 또는 이의 항원-결합 부분, 및/또는 상기 재조합 ACE2가 대상체에게 발현된다.
특정 구현양태에서, a) 제 1 용기; b) 제 1 용기 내부에 있고 다가양이온성 구조를 포함하고 핵산 분자가 없거나 본질적으로 없는 제 1 조성물; c) 제 2 용기; 및 d) 제 2 용기 내부에 있고 적어도 하나의 항-SARS-CoV-2 항체 또는 이의 항원-결합 부분, 또는 ACE2 단백질을 암호화하는 다수의 하나 이상의 비-바이러스 발현 벡터를 포함하는 제 2 조성물을 포함하는 시스템이 제공된다.
일부 구현양태에서 시스템은 제제가 대상체에게 투여될 때 투여되지 않은 경우와 비교하여 i) 대상체에게 적어도 하나의 항-SARS-CoV-2 항체 또는 이의 항원-결합 부분 또는 ACE2 단백질의 발현 수준, ii) 및/또는 발현의 시간의 길이를 증가시키는 제제를 추가로 포함한다. 추가 구현양태에서, 제제는 제 1 조성물 및/또는 제 2 조성물에 존재한다. 다른 구현양태에서, 시스템은 제 3 용기를 추가로 포함하고, 여기서 제제는 제 3 용기에 존재한다.
특정 구현양태에서, 시스템은 항바이러스제(예를 들어, 렘데시비르 또는 ACE2 수용체의 적어도 일부를 포함하는 단백질) 및/또는 항염증제 및/또는 항응고제를 추가로 포함한다.
특정 구현양태에서, A) 대상체는 SARS-CoV-2 바이러스에 감염되고, 적어도 하나의 항-SARS-CoV-2 항체, 또는 이의 항원 결합 부분, 또는 재조합 ACE2는 i) 대상체의 SARS-CoV-2 바이러스 부하, 및/또는 ii) SARS-CoV-2 감염으로 인한 대상체의 적어도 하나의 증상을 감소시키기에 충분한 발현 수준으로 대상체에서 발현되고; 또는 B) 대상체가 SARS-CoV-2 바이러스에 감염되지 않았으며, 여기서 적어도 하나의 항-SARS-CoV-2 항체, 또는 이의 항원-결합 부분, 또는 재조합 ACE2는 대상체가 SARS-CoV-2 바이러스에 감염되는 것을 방지하기에 충분한 발현 수준으로 대상체에서 발현된다.
특정 구현양태에서, 발현 수준은 i) 단계 a) 및 b)의 임의의 추가 또는 단지 1, 2 또는 3회의 추가 반복, 및 ii) 적어도 하나의 항-SARS-CoV-2 항체 또는 이의 항원-결합 부분을 암호화하는 벡터의 임의의 추가 투여 없이 적어도 2주 동안 대상체에서 유지된다. 다른 구현양태에서, 발현 수준은 i) 단계 a) 및 b)의 임의의 추가, 또는 단지 1, 2 또는 3회의 추가 반복, 및 ii) 적어도 하나의 항-SARS-CoV-2 항체 또는 이의 항원-결합 부분을 암호화하는 벡터의 임의의 추가 투여 없이 적어도 1개월 동안 대상체에서 유지된다. 다른 구현양태에서, 발현 수준은 i) 단계 a) 및 b)의 임의의 추가, 또는 단지 1, 2 또는 3회의 추가 반복, 및 ii) 적어도 하나의 항-SARS-CoV-2 항체 또는 이의 항원-결합 부분을 암호화하는 벡터의 임의의 추가 투여 없이 적어도 1년, 또는 2년 동안 또는 대상체의 평생 동안 대상체에서 유지된다. 일부 구현양태에서, 적어도 하나의 항-SARS-CoV-2 항체 또는 이의 항원-결합 부분은 i) 적어도 25일 동안 500 ng/ml 내지 50 ug/ml, 또는 10-20 ug/ml의 수준으로, 또는 ii) 적어도 25일 동안 적어도 250 ng/ml의 수준으로 대상체에서 발현된다.
일부 구현양태에서, a) 다가양이온성 구조를 포함하고, 핵산 분자가 없거나 본질적으로 없는 제 1 조성물을 대상체에게 투여하는 단계; 및 b) 제 1 조성물을 투여한 후 대상체에게 적어도 3개의 상이한 항체 또는 이의 항원-결합 부분을 암호화하는 다수의 하나 이상의 비-바이러스 발현 벡터를 포함하는 제 2 조성물을 투여하는 단계를 포함하여, 대상체에서 적어도 3개의 상이한 항체 또는 이의 항원-결합 부분을 동시에 발현시키는 방법이 본원에 제공되며, 제 1 및 제 2 조성물을 투여한 결과, 적어도 3개의 상이한 항체 또는 이의 항원-결합 부분이 대상체에서 동시에 발현된다. 특정 구현양태에서, 적어도 3개의 상이한 항체 또는 이의 항원-결합 부분은 SARS-CoV-2 및/또는 인플루엔자 A 및/또는 인플루엔자 B에 특이적이다. 일부 구현양태에서, 적어도 3개의 상이한 항체 또는 이의 항원-결합 부분은 각각 SARS-CoV-2에 대해 완전히 또는 실질적으로 중화한다. 다른 구현양태에서, 적어도 3개의 상이한 항체 또는 이의 항원-결합 부분은 각각 HIV, 인플루엔자 A, 인플루엔자 B 및 말라리아로 이루어진 군으로부터 선택된 바이러스에 대해 완전히 또는 실질적으로 중화한다.
특정 구현양태에서, a) 제 1 용기; b) 제 1 용기 내부에 있고 다가양이온성 구조를 포함하고 핵산 분자가 없거나 본질적으로 없는 제 1 조성물; c) 제 2 용기; 및 d) 제 2 용기 내부에 있고 적어도 3개의 상이한 항체 또는 이의 항원-결합 부분 을 암호화하는 다수의 하나 이상의 비-바이러스 발현 벡터를 포함하는 제 2 조성물을 포함하는 시스템이 제공된다. 특정 구현양태에서, 시스템은 제제가 대상체에게 투여되지 않은 경우와 비교하여 대상체에게 투여될 때 i) 적어도 3개의 상이한 항체 또는 이의 항원-결합 부분의 적어도 하나의 발현 수준을 증가시키고/시키거나, ii) 및/또는 발현 시간의 길이를 증가시키는 제제를 추가로 포함한다. 추가 구현양태에서, 제제는 제 1 조성물 및/또는 제 2 조성물에 존재한다. 다른 구현양태에서, 시스템은 제 3 용기를 추가로 포함하고, 여기서 제제는 제 3 용기에 존재한다.
특정 구현양태에서, 적어도 3개의 상이한 항체 또는 이의 항원-결합 부분은 각각 적어도 100 ng/ml(예를 들어, 적어도 100...500...900 ng/ml)의 수준으로 대상체에서 발현된다. 다른 구현양태에서, 적어도 3개의 상이한 항체 또는 이의 항원-결합 부분은 각각 적어도 25일 동안 적어도 100 ng/ml의 수준으로 대상체에서 발현된다. 다른 구현양태에서, 적어도 3개의 상이한 항체 또는 이의 항원-결합 부분은 적어도 200 ng/ml의 수준으로 대상체에서 발현된다.
추가 구현양태에서, 적어도 3개의 상이한 항체 또는 이의 항원-결합 부분은 적어도 25일 동안 적어도 200 ng/ml의 수준으로 대상체에서 발현된다. 다른 구현양태에서, 여기서: A) 3개의 상이한 항체 또는 이의 항원 결합 부분 각각에 대한 발현 수준은 i) 단계 a) 및 b)의 임의의 추가 또는 단지 1개의 추가 반복; 및 ii) 적어도 3개의 상이한 항체 또는 이의 항원-결합 부분을 암호화하는 벡터의 임의의 추가 투여 없이 적어도 2주 또는 적어도 3주 동안 대상체에서 유지되고, 및/또는 B) 단계 a) 및 b)를 적어도 1회 또는 적어도 2회 반복된다. 특정 구현양태에서, 발현 수준은 i) 단계 a) 및 b)의 임의의 추가 또는 단지 1회 또는 2회 추가 반복, 및 ii) 적어도 3개의 상이한 항체 또는 이의 항원 결합 부분을 암호화하는 벡터의 임의의 추가 투여 없이 적어도 2주 또는 적어도 3주 동안 대상체에서 유지된다.
다른 구현양태에서, 하나 이상의 비-바이러스 발현 벡터는 3개의 비-바이러스 발현 벡터를 포함한다. 추가 구현양태에서, 3개의 비-바이러스 발현 벡터 각각은 상이한 항체 또는 이의 항원 결합 단편을 암호화한다. 추가 구현양태에서, 하나 이상의 비-바이러스 발현 벡터는 6개의 비-바이러스 발현 벡터를 포함한다. 추가 구현양태에서, 6개의 비-바이러스 발현 벡터 각각은 상이한 항체 경쇄 가변 영역 또는 중쇄 가변 영역을 암호화한다. 추가 구현양태에서, 하나 이상의 비-바이러스 발현 벡터는 항체 경쇄 가변 영역을 각각 암호화하는 제 1, 제 2 및 제 3 핵산 서열, 및 항체 중쇄 가변 영역을 각각 암호화하는 제 4, 제 5 및 제 6 핵산 서열을 포함한다. 다른 구현양태에서, 이의 항원-결합 부분은 Fab', F(ab)2, Fab 및 미니바디로 이루어진 군으로부터 선택된다.
일부 구현양태에서, 적어도 3개의 상이한 항체 또는 이의 항원-결합 부분 중 적어도 하나는 항-SARS-CoV-2 항체 또는 이의 항원 결합 부분이다. 다른 구현양태에서, 적어도 3개의 상이한 항체 또는 이의 항원 결합 부분 중 적어도 하나는 표 4 및/또는 표 7로부터 선택된 항체 또는 이의 항원 결합 부분이다. 추가 구현양태에서, 적어도 3개의 상이한 항체 또는 이의 항원 결합 부분은 이의 항원 결합 부분은 적어도 4개, 5개, 6개, 7개 또는 8개의 상이한 항체 또는 이의 항원 결합 부분을 포함한다. 일부 구현양태에서, 투여는 정맥내 투여를 포함한다.
일부 구현양태에서, 본원은 a) 다가양이온성 구조를 포함하고, 핵산 분자가 없거나 본질적으로 없는 제 1 조성물을 대상체에게 투여하는 단계; 및 b) 제 1 조성물을 투여한 후 대상체에게 인간 성장 호르몬(hGH) 및/또는 반감기 연장 펩티드에 연결된 hGH(hGH-ext)를 암호화하는 다수의 비-바이러스성 발현 벡터를 포함하는 제 2 조성물을 투여하는 단계를 포함하는 방법을 제공하고, 여기서, 제 1 및 제 2 조성물을 투여한 결과, 대상체에서 hGH가 발현된다.
특정 구현양태에서, hGH 및/또는 hGH-ext는 적어도 1 ng/ml(예를 들어, 적어도 1...10...100...500 ng/ml)의 혈청 발현 수준으로 대상체에서 발현된다. 다른 구현양태에서, 발현 수준은 i) 단계 a) 및 b)의 임의의 추가 또는 단지 하나의 추가 반복, 및 ii) hGH 또는 hGH-ext를 암호화하는 벡터의 임의의 추가 투여 없이 적어도 2주 동안 대상체에서 유지된다. 다른 구현양태에서, 발현 수준은 i) 단계 a) 및 b)의 임의의 추가 또는 단지 하나의 추가 반복, 및 ii) hGH또는 hGH-ext를 암호화하는 벡터의 임의의 추가 투여 없이 적어도 1개월 동안 대상체에서 유지된다. 추가 구현양태에서, 발현 수준은 i) 단계 a) 및 b)의 임의의 추가 또는 단지 하나의 추가 반복, 및 ii) hGH또는 hGH-ext를 암호화하는 벡터의 임의의 추가 투여 없이 적어도 1년 동안 대상체에서 유지된다. 추가 구현양태에서, 다수의 비-바이러스 발현 벡터는 hGH-ext를 암호화하고, 여기서 반감기 연장 펩티드는 Fc 영역 펩티드, 혈청 알부민, 인간 융모성성선자극호르몬 b-서브유닛(CTP), 및 XTEN의 카복시 말단 펩티드로 이루어진 군으로부터 선택된다(Schellenberger et al., Nat Biotechnol. 2009 Dec;27(12):1186-90). 추가의 구현양태에서, 방법은 c) 제 1 및/또는 제 2 조성물에 존재하거나 제 3 조성물에 존재하는 제제를 투여하는 단계를 추가로 포함하며, 여기서 제제는 제제가 대상체에게 투여되지 않은 경우와 비교하여 i) hGH 및/또는 hGH-ext의 발현 수준을 증가시키고/시키거나 ii) 및/또는 발현 시간의 길이를 증가시킨다.
일부 구현양태에서, a) 제 1 용기; b) 제 1 용기 내부에 있고 다가양이온성 구조를 포함하고 핵산 분자가 없거나 본질적으로 없는 제 1 조성물; c) 제 2 용기; 및 d) 제 2 용기 내부에 있고 인간 성장 호르몬(hGH) 및/또는 반감기 연장 펩티드에 연결된 hGH(hGH-ext)를 암호화하는 다수의 비-바이러스성 발현 벡터를 포함하는 제 2 조성물을 포함하는 시스템이 제공된다. 특정 구현양태에서, 시스템은 제제가 대상체에게 투여되지 않은 경우와 비교하여 대상체에게 투여될 때 i) hGH 및/또는 hGH-ext의 발현 수준을 증가시키고/시키거나 ii) 및 또는 발현 시간의 길이를 증가시키는 제제를 추가로 포함한다. 다른 구현양태에서, 제제는 제 1 조성물 및/또는 제 2 조성물에 존재한다. 특정 구현양태에서, 시스템은 제 3 용기를 추가로 포함하고, 제제는 제 3 용기에 존재한다.
일부 구현양태에서, 본원은 a) 다가양이온성 구조를 포함하고 핵산 분자가 없거나 본질적으로 없는 제 1 조성물을 대상체에게 투여하는 단계; b) 제 1 조성물을 투여한 후 대상체에게 각각 제 1 단백질 및/또는 제 1 생물학적 활성 핵산 분자를 암호화하는 제 1 핵산 서열을 포함하는 다수의 발현 벡터를 포함하는 제 2 조성물을 투여하는 단계; 및 c) 제 1 및/또는 제 2 조성물에 있거나 제 3 조성물에 존재하는 제제를 투여하는 단계를 포함하는 방법이 제공되며, 여기서 제제는 제제가 대상체에게 투여되지 않은 경우와 비교하여 i) 제 1 단백질 또는 제 1 생물학적 활성 핵산 분자의 발현 수준을 증가시키고/시키거나; ii) 및/또는 발현 시간의 길이를 증가시키고; 및/또는 iii) 알라닌 아미노트랜스퍼라제(ALT) 수준에 의해 측정된 바와 같이 독성을 감소시키고; 여기서 제제는 도코사헥사에노산(DHA), 에이코사페나에노산(EPA), 알파 리놀렌산(ALA), 리폭신 A4(LA4), 15-데옥시-12,14-프로스타글란딘 J2(15d), 아라키돈산(AA), 코코사펜타에노산(DPA), 레티노산(RA), 디알릴 디설파이드(DADS), 올레산(OA), 알파 토코페롤(AT), 스핑고신-1-포스페이트(S-1-P), 팔미토일 스핑고미엘린(SPH), 항-TNFα 항체 또는 이의 항원 결합 단편, 헤파리노이드 및 N-아세틸-데-O-설페이트된 헤파린으로 이루어진 군으로부터 선택되고; 여기서, 제 1 및 제 2 조성물 및 제제를 대상체에게 투여한 결과, 제 1 단백질 또는 제1 생물학적 활성 핵산 분자가 대상체에서 발현된다.
다른 구현양태에서, 제 1 단백질 또는 제 1 생물학적 활성 핵산 분자는 적어도 10 ng/ml 또는 적어도 100 ng/ml의 혈청 발현 수준으로 대상체에서 발현된다. 추가 구현양태에서, 발현 수준은 i) 단계 a), b) 및 c)의 임의의 추가 또는 단 한 번의 추가 반복, 및 ii) 제 1 단백질 또는 제 1 생물학적 활성 핵산 분자를 암호화하는 벡터의 임의의 추가 투여 없이 적어도 2주 동안 대상체에서 유지된다. 추가 구현양태에서, 발현 수준은 i) 단계 a), b) 및 c)의 임의의 추가 또는 단 한 번의 추가 반복, 및 ii) 제 1 단백질 또는 제 1 생물학적 활성 핵산 분자를 암호화하는 벡터의 임의의 추가 투여 없이 적어도 1개월 동안 대상체에서 유지된다. 추가 구현양태에서, 발현 수준은 i) 단계 a), b) 및 c)의 임의의 추가 또는 단 한 번의 추가 반복, 및 ii) 제 1 단백질 또는 제 1 생물학적 활성 핵산 분자를 암호화하는 벡터의 임의의 추가 투여 없이 적어도 1년 동안 대상체에서 유지된다. 다른 구현양태에서, 제 1 핵산 서열은 제 1 단백질 또는 제 1 생물학적 활성 핵산 분자를 제공하고, 여기서 제 1 생물학적 활성 핵산 분자는 siRNA 또는 shRNA 서열, miRNA 서열, 안티센스 서열, CRISPR 다량체화 단일 가이드 및 CRISPR 단일 가이드 RNA 서열(sgRNA)로부터 선택된 서열을 포함한다. 다른 구현양태에서, 각각의 발현 벡터는 i) 제 2 치료 단백질, 및/또는 ii) 제 2 생물학적 활성 핵산 분자를 암호화하는 제 2 핵산 서열을 추가로 포함한다.
일부 구현양태에서, 제제는 제 1 조성물에 존재한다. 특정 구현양태에서, 제제는 제 3 조성물에 존재하고, 제 1 조성물보다 적어도 1시간 전에 투여된다. 추가 구현양태에서, 제제는 도코사헥사에노산(DHA)을 포함한다. 추가 구현양태에서, 제제는 에이코사페나에노산(EPA)을 포함한다.
추가 구현양태에서, a) 제 1 용기; b) 제 1 용기 내부에 있고 다가양이온성 구조를 포함하고 핵산 분자가 없거나 본질적으로 없는 제 1 조성물; c) 제 2 용기; d) 제 2 용기 내부에 있고 제 1 단백질 및/또는 제 1 생물학적 활성 핵산 분자를 암호화하는 제 1 핵산 서열을 포함하는 다수의 발현 벡터를 포함하는 제 2 조성물; 및 e) 제 1 및/또는 제 2 조성물에 존재하거나 제 3 용기에 제 3 조성물에 존재하는 제제를 포함하는 시스템이 제공되며, 여기서 제제는 도코사헥사에노산(DHA), 에이코사페나에노산(EPA), 알파 리놀렌산(ALA), 리폭신 A4(LA4), 15-데옥시-12,14-프로스타글란딘 J2(15d), 아라키돈산(AA), 코코사펜타에노산(DPA), 레티노산(RA), 디알릴 디설파이드(DADS), 올레산(OA), 알파 토코페롤(AT), 스핑고신-1-포스페이트(S-1-P), 팔미토일 스핑고미엘린(SPH), 항-TNFα 항체 또는 이의 항원 결합 단편, 헤파리노이드 및 N-아세틸-데-O-설페이트된 헤파린으로 이루어진 군으로부터 선택된다.
추가 구현양태에서, 제제는 제제가 대상체에게 투여되지 않은 경우와 비교하여 i) 제 1 단백질 또는 제 1 생물학적 활성 핵산 분자의 발현 수준을 증가시키고/시키거나, ii) 및/또는 발현 시간의 길이를 증가시키고 및/또는 iii) 알라닌 아미노트랜스퍼라제(ALT) 수준에 의해 측정된 바와 같이 독성을 감소시킨다. 다른 구현양태에서, 제제는 제 1 조성물 및/또는 제 2 조성물에 존재한다. 추가 구현양태에서, 시스템은 상기 제 3 용기를 추가로 포함하고, 제제는 제 3 용기에 존재한다.
일부 구현양태에서, 본원은 a) 대상체의 기도를 통해 대상체에게 제 1 조성물을 투여하는 단계, 여기서 제 1 조성물은 다가양이온성 구조를 포함하고, 핵산 분자가 없거나 본질적으로 없고; 및 b) 제 1 조성물을 투여한 후 대상체에게 제 2 조성물을 투여하는 단계를 포함하는 방법을 제공하며, 투여는 대상체의 기도를 통해 이루어지며, 제 2 조성물은 각각 제 1 단백질 또는 제 1 생물학적 활성 핵산 분자을 암호화하는 제 1 핵산 서열을 포함하는 다수의 발현 벡터를 포함하고; 여기서, 대상체에게 제 1 및 제 2 조성물을 투여한 결과, 제 1 단백질 또는 제 1 생물학적 활성 핵산 분자가 대상체에서 발현된다.
특정 구현양태에서, 제 1 단백질 또는 제 1 생물학적 활성 핵산 분자는 대상체의 폐에서 발현된다. 추가 실시 형태에서, 제 1 조성물은 수성 조성물 또는 동결-건조 조성물이다. 다른 구현양태에서, 제 2 조성물은 수성 조성물 또는 동결-건조 조성물이다. 추가의 구현양태에서, 다가양이온성 구조는 1,2-디올레오일-3-트리메틸암모늄-프로판(DOTAP); 1,2-디미리스토일-sn-글리세로-3-포스포콜린(DMPC); 1,2-디올레오일-sn-글리세로-3-포스포-L-세린(DOPS); 및 1-스테아로일-2-올레오일-sn-글리세로-3-포스포-L-세린으로 이루어진 군으로부터 선택된 지질을 포함한다. 다른 구현양태에서, 대상체는 폐 염증을 갖는다. 추가 구현양태에서, 대상체는 인공 호흡기를 착용하고 있다.
추가적인 구현양태에서, a) 제 1 용기; b) 제 1 용기 내부에 있고 다가양이온성 구조를 포함하고, 핵산 분자가 없거나 본질적으로 없는 제 1 조성물, 여기서다가양이온성 구조는 1,2-디올레오일-sn-글리세로-3-포스포-L-세린(DOPS); 및 1-스테아로일-2-올레오일-sn-글리세로-3-포스포-L-세린으로 이루어진 군으로부터 선택된 지질을 포함하고; c) 제 2 용기; 및 d) 제 2 용기 내부에 있고 제 1 단백질 및/또는 제 1 생물학적 활성 핵산 분자를 암호화하는 제 1 핵산 서열을 각각 포함하는 다수의 발현 벡터를 포함하는 제 2 조성물을 포함하는 시스템이 제공된다.
일부 구현양태에서, a) 제 1 용기; b) 제 1 용기 내부에 있고 다가양이온성 구조를 포함하고, 핵산 분자가 없거나 본질적으로 없는 제 1 조성물; c) 제 2 용기; 및 d) 제 2 용기 내부에 있고 제 1 단백질 및/또는 제 1 생물학적 활성 핵산 분자를 암호화하는 제 1 핵산 서열을 각각 포함하는 다수의 발현 벡터를 포함하는 제 2 조성물을 포함하는 시스템이 제공되며, 여기서 제 1 및/또는 제 2 조성물은 동결-건조 조성물이다.
일부 구현양태에서, i) 에멀젼 및/또는 다수의 리포좀, 및 ii) 제제를 포함하는 조성물을 대상체에게 투여하는 것을 포함하여, 대상체를 치료하는 방법이 본원에 제공되며, 여기서 대상체는 염증, 자가면역 질병, 면역-결핍 질병, SARS-CoV-2 감염을 갖고/갖거나 관문 억제제를 투여받고 있으며, 여기서 제제는 덱사메타손, 덱사메타손 팔미테이트, 덱사메타손 지방산 에스테르, 도코사헥사에노산(DHA), 에이코사페나에노산(EPA), 알파 리놀렌산(ALA), 리폭신 A4(LA4), 15-데옥시-12,14-프로스타글란딘 J2(15d), 아라키돈산(AA), 코코사펜타에노산(DPA), 레티노산(RA), 디알릴 디설파이드(DADS), 올레산(OA), 알파 토코페롤(AT), 스핑고신-1-포스페이트(S-1-P), 팔미토일 스핑고미엘린(SPH), 항-TNFα 항체 또는 이의 항원 결합 단편, 헤파리노이드 및 N-아세틸-데-O-설페이트된 헤파린으로 이루어진 군으로부터 선택된다. 추가 구현양태에서, 투여는 기도 투여를 포함한다. 다른 구현양태에서, 투여는 전신 투여를 포함한다. 다른 구현양태에서, 조성물은 리포좀을 포함하고, 제제는 리포좀에 혼입된다. 다른 구현양태에서, 조성물은 리포좀에 없는 하나 이상의 제제를 추가로 포함한다. 추가 구현양태에서, 조성물은 핵산 분자가 없거나 본질적으로 없다. 다른 구현양태에서, 대상체는 SARS-CoV-2에 감염되고, 방법은 대상체에게 항바이러스제를 투여하는 것을 추가로 포함한다. 추가 구현양태에서, 항바이러스제는 렘데시비르 또는 ACE2 수용체의 적어도 일부를 포함하는 단백질을 포함한다. 다른 구현양태에서, 상기 방법은 대상체에게 항염증제 및/또는 항응고제를 투여하는 단계를 추가로 포함한다. 일부 구현양태에서, 조성물은 수성 조성물 또는 동결-건조 조성물이다. 추가 구현양태에서, 리포좀은 1,2-디올레오일-3-트리메틸암모늄-프로판(DOTAP); 1,2-디미리스토일-sn-글리세로-3-포스포콜린(DMPC); 1,2-디올레오일-sn-글리세로-3-포스포-L-세린(DOPS); 및 1-스테아로일-2-올레오일-sn-글리세로-3-포스포-L-세린으로 이루어진 군으로부터 선택된 지질을 포함한다.
특정 구현양태에서, 본원은 a) 다가양이온성 구조를 포함하고, 핵산 분자가 없거나 본질적으로 없는 제 1 조성물을 동물 모델에 투여하는 단계, 여기서 동물 모델은 SARS-CoV-2에 감염되었고; 및 b) 제 1 조성물을 투여한 후 동물 모델에 제 1 및 제 2 항-SARS-CoV-2 항체 또는 항원-결합을 암호화하는 다수의 하나 이상의 비-바이러스 발현 벡터를 포함는 제 2 조성물을 투여하는 단계, 상기 제 1 및 제 2 조성물을 투여한 결과, 상기 제 1 및 제 2 후보 항-SARS-CoV-2 항체 또는 이의 항원 결합 부분이 동물 모델에서 발현되고; 및 c) 제 1 및 제 2 후보 항-SARS-CoV-2 항체 또는 이의 항원 결합 부분의 발현이 i) 동물 모델에서 SARS-CoV-2 바이러스 부하를 감소시키고/시키거나, ii) SARS-CoV-2 감염으로 인한 동물 모델에서 하나 이상의 증상을 감소시키는 정도를 결정하는 단계를 포함하는 방법이 제공된다. 특정 구현양태에서, 다수의 하나 이상의 비-바이러스 발현 벡터는 제 3, 4, 5, 6, 7, 8, 9, 10 또는 11 후보 항-SARS-CoV-2 항체 또는 이의 항원 결합 단편을 추가로 암호화한다. 특정 구현양태에서, 동물 모델은 마우스, 래트, 햄스터, 기니피그, 영장류, 원숭이, 침팬지 또는 토끼로부터 선택된다. 추가 구현양태에서, 제 1 및 항-SARS-CoV2 항체 또는 이의 항원 결합 부분은 표 7 또는 표 5에 제시되어 있다. 추가 구현양태에서, 제 1 및 제 2 항-SARS-CoV2 항체 또는 이의 항원 결합 부분은 REGN10933, REGN10987; VIR-7831; LY-CoV1404; LY3853113; Zost 2355K; CV07-209K; C121L; Zost 2504L; CV38-183L; COVA215K; RBD215; CV07-250L; C144L; COVA118L; C135K; 및 B38로부터 선택된다. 특정 구현양태에서, 제 1 및 제 2 항-SARS-CoV2 항체 또는 이의 항원 결합 부분은 REGN10933 및 REGN10987이다.
추가의 구현양태에서, 다가양이온성 구조는 양이온성 지질을 포함한다. 일부 구현양태에서, 제 1 조성물은 다수의 리포좀을 포함하고, 상기 리포좀 중 적어도 일부는 상기 양이온성 지질을 포함한다. 다른 구현양태에서, 상기 리포좀의 적어도 일부는 중성 지질을 포함한다. 추가의 구체예에서, 상기 리포좀에서 상기 양이온성 지질 대 상기 중성 지질의 비율은 95:05-80:20 또는 약 1:1이다. 다른 구현양태에서, 양이온성 및 중성 지질은 디스테아로일 포스파티딜 콜린(DSPC); 수소화 또는 비수소화 대두 포스파티딜콜린(HSPC); 디스테아로일 포스파티딜에탄올아민(DSPE); 달걀 포스파티딜콜린(EPC); 1,2-디스테아로일-sn-글리세로-3-포스포-rac-글리세롤(DSPG); 디미리스토일 포스파티딜콜린(DMPC); 1,2-디미리스토일-sn-글리세로-3-포스포글리세롤(DMPG); 1,2-디팔미토일-sn-글리세로-3-포스페이트(DPPA); 트리메틸암모늄 프로판 지질; DOTIM(1-[2-9(2)-옥타데세노일옥시)에틸]-2-(8(2)-헵타데세닐)-3-(2-히드록시에틸)미디졸리늄 클로라이드) 지질; 및 이들 중 둘 이상의 혼합물로 이루어진 군으로부터 선택된다.
일부 구현양태에서, 하나 이상의 비-바이러스 발현 벡터는 플라스미드를 포함하며, 여기서 플라스미드는 임의의 전달제에 부착되거나 캡슐화되지 않는다. 추가 구현양태에서, 하나 이상의 비-바이러스 발현 벡터는 항체 경쇄 가변 영역을 암호화하는 제 1 핵산 서열, 및 항체 중쇄 가변 영역을 암호화하는 제 2 핵산 서열, 및 임의로, 항체 경쇄 가변 영역을 암호화하는 제 3 핵산 서열 및 항체 중쇄 가변 영역을 암호화하는 제 4 핵산 서열을 포함한다. 특정 구현양태에서, A) 이의 항원-결합 부분은 Fab', F(ab)2, Fab 및 미니바디로 이루어진 군으로부터 선택되고/되거나, B) 적어도 하나의 항-SARS-CoV-2 항체 또는 이의 항원 결합 부분은 상이한 SARS-CoV-2 항원에 대해 이중특이적이다. 다른 구현양태에서, 항-SARS-CoV-2 항체는 REGN10933, REGN10987; VIR-7831; LY-CoV1404; LY3853113; Zost 2355K; CV07-209K; C121L; Zost 2504L; CV38-183L; COVA215K; RBD215; CV07-250L; C144L; COVA118L; C135K; 및 B38로 이루어진 군으로부터 선택된 모노클로날 항체이다. 이들 항체는 각각 본원에 참조로 포함된 다음 참고 문헌에 설명되어 있다(Zost et al., Nature Medicine volume 26, pages1422-1427 (2020); Robbiani et al., Nature volume 584, pages437-442 (2020); and Wu et al., Science, 2020 Jun 12;368(6496):1274-1278; 및 표 7). 이들 항체의 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16 또는 17개 모두의 조합 또는 이들의 항원 결합 단편은 본원에 기술된 임의의 구현양태에서 사용될 수 있다. 일부 구현양태에서, 항-SARS-CoV-2 항체 또는 이의 항원-결합은 다음의 적어도 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 또는 그 이상의 조합을 포함한다: REGN10933, REGN10987; VIR-7831; LY-CoV1404; LY3853113; Zost 2355K; CV07-209K; C121L; Zost 2504L; CV38-183L; COVA215K; RBD215; CV07-250L; C144L; COVA118L; C135K; 및 B38(또는 표 7 또는 표 5에 나타낸 것 중 임의의 것). 추가 구현양태에서, 항-SARS-CoV-2 항체 또는 이의 항원 결합 부분은 표 7에 기술된 바와 같다.
일부 구현양태에서, 적어도 하나의 항-SARS-CoV-2 항체 또는 이의 항원 결합 부분은 적어도 2개의 항-SARS-CoV-2 항체 및/또는 이의 항원 결합 부분을 포함하며, 이는 i) 대상체에서 SARS-CoV-2 바이러스 부하, 및/또는 ii) SARS-CoV-2 감염으로 인한 대상체의 적어도 하나의 증상을 감소시키기에 충분한 발현 수준으로 대상체에서 발현된다. 다른 구현양태에서, 적어도 하나의 항-SARS-CoV-2 항체 또는 이의 항원 결합 부분은 적어도 4개, 또는 적어도 8개 또는 적어도 11개의 항-SARS-CoV-2 항체 및/또는 이의 항원-결합 부분을 포함한다. 추가 구현양태에서, 적어도 하나의 항-SARS-CoV-2 항체 또는 이의 항원 결합 부분은 적어도 4개, 또는 적어도 8개 또는 적어도 11개의 항-SARS-CoV-2 항체 및/또는 이의 항원 결합 부분을 포함하며, 이는 i) 대상체에서 SARS-CoV-2 바이러스 부하, 및/또는 ii) SARS-CoV-2 감염으로 인한 대상체의 적어도 하나의 증상을 감소시키기에 충분한 발현 수준으로 대상체에서 발현된다.
일부 구현양태에서, 투여는 정맥내 투여를 포함한다. 다른 구현양태에서, 제 2 조성물은 i) 제 1 조성물 후 0.5 내지 80분 사이에, 또는 제 1 조성물 후 약 1 내지 20분 사이에 투여된다. 특정 구현양태에서, 방법은 c) 제 1 및/또는 제 2 조성물에 존재하거나 제 3 조성물에 존재하는 제제를 투여하는 단계를 추가로 포함하며, 여기서 제제는 제제가 대상체에게 투여되지 않은 경우와 비교하여 i) 적어도 하나의 항-SARS-CoV-2 항체 또는 이의 항원 결합 부분의 발현 수준 및/또는 ii) 및/또는 발현 시간의 길이를 증가시킨다. 다른 구현양태에서, 제제는 제 1 조성물에 존재한다. 특정 구현양태에서, 제제는 제 3 조성물에 존재하고, 제 1 조성물보다 적어도 1시간 전에 투여된다. 일부 구현양태에서, 제제는 덱사메타손, 덱사메타손 팔미테이트, 덱사메타손 지방산 에스테르, 도코사헥사에노산(DHA), 에이코사페나에노산(EPA), 알파 리놀렌산(ALA), 리폭신 A4(LA4), 15-데옥시-12,14-프로스타글란딘 J2(15d), 아라키돈산(AA), 코코사펜타에노산(DPA), 레티노산(RA), 디알릴 디설파이드(DADS), 올레산(OA), 알파 토코페롤(AT), 스핑고신-1-포스페이트(S-1-P), 팔미토일 스핑고미엘린(SPH), 항-TNFα 항체 또는 이의 항원 결합 단편, 헤파리노이드 및 N-아세틸-데-O-설페이트된 헤파린으로 이루어진 군으로부터 선택된다. 특정 구현양태에서, 덱사메타손 지방산 에스테르는 하기 화학식을 갖는다:
특정 구현양태에서, 제제(예를 들어, 수용성 덱사메타손, 일명 덱사메타손 시클로덱스트린 포접 복합체; Sigma Sku D2915 참조)는 0.1-35 mg/ml 또는 0.001-1.0 mg/ml(예를 들어, 0.001 ... 0.005 ... 0.01 ... 0.05 ... 0.1 ... 0.5 ... 1.0 mg/ml)의 농도로 제 1, 제 2 또는 제 3 조성물에 존재한다. 다른 구현양태에서, 대상체는 폐, 심혈관 및/또는 다기관 염증을 갖는다. 특정 구현양태에서, 대상체는 인공 호흡기를 착용하고 있다.
일부 구현양태에서, 제 1 및/또는 제 2 조성물은 생리학적으로 허용되는 완충액 또는 정맥내 용액을 추가로 포함한다. 다른 구현양태에서, 제 1 및/또는 제 2 조성물은 락테이트 링거액 또는 식염수를 추가로 포함한다.
추가 구현양태에서, 제 1 조성물은 다가양이온성 구조를 포함하는 리포좀을 포함하고, 여기서 리포좀은 만노스 모이어티, 말레이미드 모이어티, 엽산 수용체 리간드, 엽산, 엽산 수용체 항체 또는 이의 단편, 포르밀 펩티드 수용체 리간드, N-포르밀-Met-Leu-Phe, 테트라펩티드 Thr-Lys-Pro-Arg, 갈락토스 및 락토비온산으로 이루어진 군으로부터 선택되는 하나 이상의 대식세포 표적화 모이어티를 추가로 포함한다. 다른 구현양태에서, 다수의 하나 이상의 비-바이러스성 발현 벡터는 임의의 전달제에 부착되거나 캡슐화되지 않는다.
특정 구현양태에서, 대상체는 인간이다. 특정 구현양태에서, 0.05-60 mg/mL의 발현 벡터가 제 2 조성물에 존재한다. 다른 구현양태에서, 다가양이온성 구조는 제 1 조성물에 0.5-100 mM의 농도로 존재하는 양이온성 리포좀을 포함한다. 추가 구현양태에서, 대상체는 인간이고, 여기서: i) 제 1 조성물의 양은 인간이 다가양이온성 구조의 2-50 mg/kg의 투여량을 받도록 투여되고/되거나 ii) 제 2 조성물의 양은 인간이 발현 벡터의 0.05-60 mg/kg의 투여량을 받도록 투여된다.
일부 구현양태에서, 다가양이온성 구조는 양이온성 리포좀을 포함하고, 여기서 양이온성 리포좀은 지질 이중층 통합 펩티드 및/또는 표적 펩티드를 추가로 포함한다. 특정 구현양태에서, 지질 이중층 통합 펩티드는 계면활성제 단백질 D(SPD), 계면활성제 단백질 C(SPC), 계면활성제 단백질 B(SPB) 및 계면활성제 단백질 A(SPA)로 이루어진 군으로부터 선택되고, ii) 표적 펩티드는 미세소관-연관 서열(MTAS), 핵 국소화 신호(NLS), ER 분비 펩티드, ER 보유 펩티드 및 퍼옥시좀 펩티드로 이루어진 군으로부터 선택된다.
다른 구현양태에서, 단계 a) 및 b)는 초기 단계 b) 후 1 내지 60일 사이에 반복된다. 일부 구현양태에서, 각각의 비-바이러스 발현 벡터는 5,500 내지 30,000개의 핵산 염기쌍을 포함한다. 특정 구현양태에서, 상기 방법은 대상체에게 항바이러스제를 투여하는 단계를 추가로 포함한다. 일부 구현양태에서, 항바이러스제는 렘데시비르 또는 ACE2 수용체의 적어도 일부를 포함하는 단백질을 포함한다. 추가 구현양태에서, 방법은 항염증제 및/또는 항응고제를 대상체에 투여하는 단계를 추가로 포함한다. 일부 구현양태에서, 하나 이상의 비-바이러스 발현 벡터는 CPG가 없거나 CPG가 감소된다.
일부 구현양태에서, 본원의 제제는 덱사메타손 지방산 에스테르(예를 들어, 화학식 I에 나타낸 바와 같은)를 포함한다. 예를 들어, 덱사메타손 팔미테이트는 하기 화학식(화학식 I)을 갖는다:
팔미테이트 기를 대체하는 또 다른 지방산 에스테르를 갖는 덱사메타손의 다른 지방산 에스테르도 사용될 수 있다. 일부 구현양태에서, 지방산 에스테르는 C6-C24 지방산 에스테르, 예컨대 헥사노에이트(카프로에이트), 헵타노에이트(에난테이트), 옥타노에이트(카프릴레이트), 노나노에이트(펠라고네이트), 데카노에이트(카프레이트), 운데카노에이트, 도데카노에이트(라우레이트), 테트라데카노에이트(미리스테이트), 옥타데세노에이트(스테아레이트), 이코사노에이트(아라키데이트), 도코사노에이트(베헤네이트) 및 테트라코사노에이트(리그노세레이트)이다. 따라서, 일부 구현양태에서, 화합물은 덱사메타손 카프로에이트, 덱사메타손 에난테이트, 덱사메타손 카프릴레이트, 덱사메타손 펠라고네이트, 덱사메타손 카프레이트, 덱사메타손 운데카노에이트, 덱사메타손 라우레이트, 덱사메타손 미리스테이트, 덱사메타손 팔미테이트, 덱사메타손 스테아레이트, 덱사메타손 아라키데이트, 덱사메타손 베헤네이트, 덱사메타손 리그노세레이트로부터 선택된다.
특정 구현양태에서, 제제는 화학식 I의 상기 덱사메타손 지방산 에스테르이고, 여기서 R1은 C5-C23 알킬이다. 다른 구체예에서, 제제는 화학식 I의 상기 덱사메타손 지방산 에스테르이고, 여기서 R1은 C5-C23 직쇄 알킬이다. 다른 구체예에서, 제제는 화학식 I의 상기 덱사메타손 지방산 에스테르이고, 여기서 R1은 C15 알킬이다.
특허 또는 출원 파일에는 컬러로 실행된 도면이 하나 이상 포함되어 있다. 컬러 도면이 포함된 이 특허 또는 특허 출원 공보의 사본은 요청 및 필요한 수수료 지불 시 특허청에서 제공한다.
도 1은 4개의 상이한 항체 또는 항체 단편(항-IL5; 5J8 항-플루; 항-SARS-CoV-2; 및 항-CD20)에 대한 36일에 걸쳐 발현 수준을 보여주는 실시예 1의 결과를 보여준다.
도 2는 항-SARS-CoV-2 항체에 대한 43일에 걸쳐 발현 수준과 항-IL5, 5J8 항-flu 및 항-Sars-Cov2에 대한 발현 데이터를 보여주는 실시예 2의 결과를 보여준다.
도 3a는 다수의 독특한 모노클로날 항체의 발현 수준을 보여주는 실시예 3의 결과를 보여준다. 도 3b는 초기 주입 후 29일에 걸쳐 다양한 시점에서 항체의 발현 수준을 보여주는 실시예 3의 결과를 보여준다.
도 4는 주입 후 특정 일자에 항체의 발현 수준을 보여주는 실시예 4의 결과를 보여준다.
도 5a는 15일에 걸쳐 다양한 단백질의 발현 수준을 보여주는 실시예 5의 결과를 보여준다. 도 5b는 22일에 걸쳐 다양한 단백질의 발현 수준을 보여주는 실시예 5의 결과를 보여준다.
도 6은 22일에 걸쳐 다양한 항체의 발현 수준을 보여주는 실시예 6의 결과를 보여준다.
도 7은 다양한 단백질의 발현 수준을 보여주는 실시예 7의 결과를 보여준다.
도 8a 및 8b는 9일에 걸쳐 cDNA-암호화된 재조합 ACE2 단백질의 발현 수준을 보여주는 실시예 8의 결과를 보여준다.
도 9는 인간 ACE2 및 이의 변이체의 발현 수준을 보여주는 실시예 9의 결과를 보여준다.
도 10은 플라스미드 070120 # 1 : B38-람다-BV3 (서열번호: 10)에 대한 핵산 서열을 보여준다.
도 11은 플라스미드 070120 # 11 : B38H-B38L-BV3: 이중 (서열번호: 11)에 대한 핵산 서열을 보여준다.
도 12은 플라스미드 070320 # 4 : B38-카파-BV3 (서열번호: 12)에 대한 핵산 서열을 보여준다.
도 13은 플라스미드 071320 # 3 : H4-카파-BV3 (서열번호: 13)에 대한 핵산 서열을 보여준다.
도 14은 플라스미드 080920 # 6 : H4-H4-카파-BV3 (서열번호: 14)에 대한 핵산 서열을 보여준다.
도 15은 플라스미드 072620 # 5A : 4A8-BV3 (서열번호: 15)에 대한 핵산 서열을 보여준다.
도 16은 플라스미드 081820 # 2 : 4A8-4A8-BV3 (서열번호: 16)에 대한 핵산 서열을 보여준다.
도 17은 플라스미드 081820 # 3 : 4A8-B38카파-BV3 (서열번호: 17)에 대한 핵산 서열을 보여준다.
도 18은 플라스미드 081820 # 4 : 4A8-H4-BV3 (서열번호: 18)에 대한 핵산 서열을 보여준다.
도 19은 플라스미드 081820 # 5 : 4A8-shACE2-BV3 (서열번호: 19)에 대한 핵산 서열을 보여준다.
도 20은 플라스미드 080420 # 3 : shACE2-BV3 (서열번호: 20)에 대한 핵산 서열을 보여준다.
도 21은 플라스미드 082020 # 1 : shACE2 TYLTNY-BV3 (서열번호: 21)에 대한 핵산 서열을 보여준다.
도 22은 플라스미드 081320 # 2A : shACE2-1xL-Fc-BV3(서열번호: 22)에 대한 핵산 서열을 보여준다.
도 23은 플라스미드 081320 # 4A : shACE2-1xL-FcLALA-BV3 (서열번호: 23)에 대한 핵산 서열을 보여준다.
도 24은 플라스미드 082620 # 5A : shACE2 TYLTNY-1xL-FcLALA-BV3 (서열번호: 24)에 대한 핵산 서열을 보여준다.
도 25은 플라스미드 080420 # 4 : shACE2-shACE2-BV3 (서열번호: 25)에 대한 핵산 서열을 보여준다.
도 26은 플라스미드 081120 # 1 : B38카파-shACE2-BV3 (서열번호: 26)에 대한 핵산 서열을 보여준다.
도 27은 플라스미드 081120 # 4 : shACE2-B38카파-BV3 (서열번호: 27)에 대한 핵산 서열을 보여준다.
도 28은 플라스미드 081120 # 2 : H4-shACE2-BV3 (서열번호: 28)에 대한 핵산 서열을 보여준다.
도 29은 플라스미드 081120 # 5 : shACE2-H4-BV3 (서열번호: 29)에 대한 핵산 서열을 보여준다.
도 30은 플라스미드 072320 # 2 : H4-aCD20-aIL5-5J8-BV2 (서열번호: 30)에 대한 핵산 서열을 보여준다.
도 31은 플라스미드 070620 # 2 : B38 람다-aCD20(Cys)-BV3(서열번호: 31)에 대한 핵산 서열을 보여준다.
도 32은 플라스미드 120717 # 1 : aCD20-aIL5-5J8-BV2 (서열번호: 32)에 대한 핵산 서열을 보여준다.
도 33은 플라스미드 122019 # 2A : GLA-1xL-hyFc (서열번호: 33)에 대한 핵산 서열을 보여준다.
도 34은 플라스미드 011215 # 7 : hGCSF-BV3 (서열번호: 34)에 대한 핵산 서열을 보여준다.
도 35은 플라스미드 071816 # 1 : (서열번호: 35)에 대한 핵산 서열을 보여준다.
도 36은 플라스미드 072520 # 4: aCD20-aCD20 (서열번호: 36)에 대한 핵산 서열을 보여준다.
도 37은 플라스미드 111517 # 1 : 5J8-5J8: 더블 2A (서열번호: 37)에 대한 핵산 서열을 보여준다.
도 38은 플라스미드111517 # 3 : aIL5-aIL5 : 더블 2A (서열번호: 38)에 대한 핵산 서열을 보여준다.
도 39은 플라스미드 111517 # 19A : 5J8-aIL5 : 이중 2A (서열번호: 39)에 대한 핵산 서열을 보여준다.
도 40은 A) 코돈 최적화 인간 성장 호르몬(hGH1) cDNA(서열번호: 40); B) hGH1-Fc(서열번호: 41); C) 링커 GGGGS(서열번호: 42), 1x링커: GGTGGAGGAGGTAGT(서열번호: 43), 2x링커: GGTGGAGGAGGTAGTGGGGGTGGAGGTTCA(서열번호: 44), 및 3x링커: GGAGGAGGTGGATCAGGTGGAGGAGGTAGTGGGGGTGGAGGTTCA (서열번호: 45); D) Fc(서열번호: 46); E) Fc 사슬A(서열번호: 47); 및 F) Fc 사슬B(서열번호: 48)의 핵산 서열을 보여준다.
도 41은 A) Fc 사슬AB(서열번호: 49); B) Fc-IgG4(서열번호: 50); C) hyFc(서열번호: 51); D) mFc(서열번호: 52); E) GAALIE(서열번호: 53); 및 F) GAALIE-LS(서열번호: 54)의 핵산 서열을 보여준다.
도 42는 A) hGH1-HSA(서열번호: 55); 및 B) HSA-K753P-링커-GH1:(서열번호: 56)의 핵산 서열을 보여준다.
도 43은 A) hGH1-CTP(서열번호: 57); B) CTP-hGH1-CTP(서열번호: 58); C) CTP-hGH1(서열번호: 59); 및 D) XTEN1-hGH1(서열번호: 60)의 핵산 서열을 보여준다.
도 44는 A) XTEN1-hGH1-XTEN2(서열번호: 61); 및 B) hGH1-XTEN2(서열번호: 62)의 핵산 서열을 보여준다.
도 45a는 Fc, 혈청 알부민 또는 Xten을 포함하는 단백질 반감기 연장 DNA 서열에 융합된 야생형 hGH cDNA의 발현이 면역적격 마우스에서 시간 경과에 따라 혈청 hGH 수준을 상당히 증가시킬 수 있음을 보여준다. 도 45b는 생성된 cDNA-암호화된 hGH 단백질이 hGH-조절된 내인성 마우스, IGF-1 단백질의 수준을 적절하게 증가시키기 때문에 완전히 생체활성임을 보여준다. 도 45c는 실시예 10 절차의 절차에서 DNA 벡터의 1회 주입이 야생형 hGH cDNA를 구동하지만 임의의 단백질 반감기 연장 DNA 서열이 결여되어 면역적격 마우스에서 치료 hGH 혈청 수준의 지속적인 생성을 생성할 수 있음을 보여준다.
도 46은 실시예 11의 절차가 Fc, 혈청 알부민 또는 Xten을 포함하는 단백질 반감기 연장 DNA 서열에 융합된 야생형 hGH cDNA를 발현하여 면역적격 마우스에서 시간 경과에 따라 혈청 hGH 수준을 상당히 증가시키는 데 사용될 수 있음을 보여준다.
도 47은 실시예 12의 절차를 사용하여 완전히 면역적격 마우스에 야생형 hGH cDNA를 구동하는 DNA 벡터의 1회 재주입이 초기 HEDGES hGH DNA 벡터 주입에 의해 생성된 혈청 hGH 수준을 상당히 그리고 지속적으로 추가로 증가시킬 수 있음을 보여준다.
도 48은 Fc 영역 단백질에 융합된 hGH의 발현 수준이 hGH의 반감기를 마우스에서 단일 DNA 주입 후 및 적어도 225일까지 연장함을 보여준다.
도 49는 처리로부터 64일까지 Fc 영역 단백질에 융합된 hGH의 발현 수준을 보여준다.
도 50a는 Fc 단백질 반감기 연장 DNA 서열에 융합된 야생형 hGH cDNA를 구동하는 DNA 벡터의 Fc 영역의 선택적 부위-지정 돌연변이유발이 면역적격 마우스에서 생성된 혈청 hGH 수준을 선택적으로 증가시키거나 감소시킬 수 있음을 보여준다. 도 50b는 Fc 단백질 반감기 연장 DNA 서열에 융합된 야생형 hGH cDNA를 구동하는 DNA 벡터의 Fc 영역의 선택적 부위-지정 돌연변이유발이 면역적격 마우스에서 시간 경과에 따라 생성된 혈청 hGH 수준을 선택적으로 증가시킬 수 있음을 보여준다.
도 51은 최적화된 몰 백분율의 덱사메타손 팔미테이트(DexPalm)를 양이온성 리포좀에 혼입시키는 것이 유전자 발현을 추가로 증가시키고 독성을 추가로 감소시킬 수 있음을 보여준다.
도 52는 최적화된 몰 백분율의 덱사메타손 팔미테이트를 양이온성 리포좀에 혼입시키는 것이 유전자 발현을 추가로 증가시키고 독성을 추가로 감소시킬 수 있음을 보여준다.
도 53은 양이온성 리포좀을 주입하기 전에 리포좀에 덱사메타손 팔미테이트의 최적화된 몰 백분율을 사전 주입하면 유전자 발현을 추가로 증가시키고 독성을 추가로 감소시킬 수 있음을 보여준다.
도 54는 양이온성 리포좀에 혼입된 일부 AIL을 주입하면 유전자 발현을 추가로 증가시키고 독성(ALT 수준)을 추가로 감소시킬 수 있음을 보여준다.
도 55는 양이온성 리포좀에 혼입된 특정 AIL을 주입하면 유전자 발현을 추가로 증가시키고 독성(ALT 수준)을 추가로 감소시킬 수 있음을 보여준다.
도 56은 최적화된 몰 백분율의 덱사메타손 팔미테이트를 양이온성 리포좀에 혼입시키는 것이 그렇지 않으면 비효과적인 hG-CSF-DNA 용량 이후에 유전자 발현의 최고 수준을 추가로 증가시킬 수 있음을 보여준다.
도 57은 비강내로 투여된 리포좀의 지질 조성을 선택적으로 변형함으로써 이들 리포좀이 상이한 정도로 폐내 단핵구 및 대식세포를 선택적으로 표적화하여 폐를 선택적으로 면역-조절할 수 있음을 보여준다.
도 58은 비경구 수용성 예비-투여량 및/또는 후속 투여된 리포좀에 혼입된 덱사메타손 팔미테이트의 몰 백분율을 선택적으로 변형함으로써, 폐 및 혈액 모두에서 T 림프구 활성화 수준이 선택적으로 면역-조절될 수 있음을 보여준다.
도 59는 비경구 수용성 예비-투여량 및/또는 후속 투여된 리포좀에 혼입된 덱사메타손 팔미테이트의 몰 백분율을 선택적으로 변형함으로써, 폐 및 혈액 모두에서 T 림프구 활성화 수준이 선택적으로 면역-조절될 수 있음을 보여준다.
도 60은 항-TNF 모노클로날 항체의 사전투여가 유전자 발현을 추가로 증가시키면서 독성을 추가로 감소시킬 수 있음을 보여준다.
도 61은 NSH의 사전 또는 사후 투여가 독성을 감소시킬 수 있음을 보여준다.
도 62는 NSH의 사전 또는 사후 투여가 독성을 감소시킬 수 있음을 보여준다.
도 63은 NSH의 사전 투여가 독성을 추가로 줄이면서 유전자 발현을 추가로 증가시킬 수 있음을 보여준다.
도 64는 덱사메타손 팔미테이트를 함유하는 리포좀의 다양한 제형의 투여가 덱사메타손 단독의 전신 투여와 비교하여 혈중 림프구 수를 감소시킨다는 것을 보여준다.
도 65는 덱사메타손 팔미테이트를 함유하는 리포좀의 다양한 제형의 투여가 덱사메타손 단독의 전신 투여와 비교하여 혈중 단핵구 수를 감소시킨다는 것을 보여준다.
도 66은 실시예 22의 결과를 보여주며, 이는 5개의 상이한 SARS-CoV2 특이적 mAb(C135, C215, COV2-2355, CV07-209 및 C121) 중 하나를 각각 암호화하는 상이한 단일 DNA 발현 플라스미드의 1회 주입이 투여 후 적어도 134일의 전체 실험 과정 동안 각 SARS-CoV2 특이 mAb의 완전 중화 혈청 수준을 생성하고 이러한 진행 중인 혈청 mAb 수준이 기능적으로 지속적으로 SARS-CoV2 스파이크 - 인간 ACE2 결합을 적어도 120일 동안 차단함을 보여준다.
도 67은 실시예 23의 결과를 보여주며, 단일 주입으로 이 절차 후 적어도 134일 동안 단일 플라스미드로부터 2개의 SARS-CoV2 특이적 mAb가 발현되고 이러한 혈청 발현 mAb 혈청이 적어도 134일 동안 SARS-CoV2 스파이크 - 인간 ACE2 상호작용을 기능적으로 차단할 수 있음을 보여준다.
도 68은 실시예 24의 결과를 보여주며, 3가지 접근 방식을 성공적으로 사용하여 시도된 3가지 접근법에 의해 2개의 항-SARS-CoV2 mAb가 동시에 발현되었음을 보여준다. 3가지 접근법 모두 SARS-CoV2/ACE2 상호작용의 중화를 허용하는 수준(도 68b는 발현 수준을 보여준다)에서 동물의 혈청에서 2개의 mAb의 발현을 성공적으로 허용한다(도 68b는 중화 능력을 보여준다).
도 69는 실시예 25의 결과를 보여주며, 총 3개의 서로 상이한 개별 SARS-CoV2 특이적 mAb를 암호화하는 1개 또는 2개의 DNA 발현 플라스미드를 매주 2회 주입하면 투여 후 적어도 70일의 과정 동안 3개의 상이한 SARS-CoV 2-특이적 mAb의 완전 중화 혈청 수준을 생성하고 이러한 진행 중인 혈청 mAb 수준이 기능적으로 지속적으로 SARS-CoV2 스파이크 - 인간 ACE2를 적어도 70일 동안 차단함을 보여준다.
도 70은 실시예 26의 결과를 보여주며, 이는 마우스에서 발현된 4개의 항-SARS-CoV-2 항체의 발현 수준 및 중화 능력을 보여준다.
도 71은 실시예 27의 결과를 보여주며, 이는 마우스에서 발현된 4개의 항-SARS-CoV-2 항체의 발현 수준 및 중화 능력을 보여준다.
도 72은 실시예 28의 결과를 보여주며, 이는 마우스에서 발현된 4개의 항-SARS-CoV-2 항체의 발현 수준 및 중화 능력을 보여준다.
도 73은 실시예 29의 결과를 보여주며, 이는 마우스에서 발현된 4개의 항-SARS-CoV-2 항체의 발현 수준 및 중화 능력을 보여준다.
도 74은 실시예 30의 결과를 보여주며, 이는 마우스에서 발현된 4개의 항-SARS-CoV-2 항체의 발현 수준 및 중화 능력을 보여준다.
도 75은 실시예 31의 결과를 보여주며, 이는 마우스에서 발현된 5개의 항-SARS-CoV-2 항체의 발현 수준 및 중화 능력을 보여준다.
도 76은 실시예 32의 결과를 보여주며, 이는 마우스에서 발현된 6개의 항-SARS-CoV-2 항체의 발현 수준 및 중화 능력을 보여준다.
도 77은 실시예 33의 결과를 보여주며, 이는 마우스에서 발현된 6개의 항-SARS-CoV-2 항체의 발현 수준 및 중화 능력을 보여준다.
도 78은 실시예 34의 결과를 보여주며, 이는 마우스에서 발현된 6개의 항-SARS-CoV-2 항체의 발현 수준 및 중화 능력을 보여준다.
도 79은 실시예 35의 결과를 보여주며, 이는 마우스에서 발현된 8개의 항-SARS-CoV-2 항체의 발현 수준 및 중화 능력을 보여준다.
도 80은 실시예 36의 결과를 보여주며, 이는 마우스에서 발현된 8개의 항-SARS-CoV-2 항체의 발현 수준 및 중화 능력을 보여준다.
도 81은 실시예 37의 결과를 보여주며, 이는 마우스에서 발현된 8개의 항-SARS-CoV-2 항체의 발현 수준 및 중화 능력을 보여준다.
도 82은 실시예 38의 결과를 보여주며, 이는 마우스에서 발현된 8개의 항-SARS-CoV-2 항체의 발현 수준 및 중화 능력을 보여준다.
도 83은 실시예 39의 결과를 보여주며, 이는 마우스에서 발현된 10개의 항-SARS-CoV-2 항체의 발현 수준 및 중화 능력 뿐만 아니라 다른 비-Sars-CoV-2 항체 및 다양한 치료 단백질의 발현 수준을 보여준다.
도 84은 실시예 40의 결과를 보여주며, 이는 마우스에서 발현된 11개의 항-SARS-CoV-2 항체의 발현 수준 및 중화 능력 뿐만 아니라 다른 비-Sars-CoV-2 항체 및 다양한 치료 단백질의 발현 수준을 보여준다.
도 85은 실시예 41의 결과를 보여주며, 이는 마우스에서 발현된 10개의 항-SARS-CoV-2 항체의 발현 수준 및 중화 능력 뿐만 아니라 다른 비-Sars-CoV-2 항체 의 발현 수준을 보여준다.
도 86a는 실시예 42로부터의 결과를 나타내며, 이는 1-48시간에 걸쳐 지시된 mAb의 발현 수준을 보여준다. 도 86b는 1-48시간의 기간에 걸쳐 지시된 mAb의 중화 능력을 보여준다.
도 87은 실시예 43의 결과를 나타내며, 단일 주입을 사용한 6개의 상이한 mAb 및 유전자의 동시 발현을 기술한다.
도 88은 실시예 44의 결과를 나타내며, 120일에 걸쳐 표적 유전자(인간 성장 호르몬)를 발현하기 위한 다양한 진핵 프로모터의 사용을 기술한다.
도 89는 실시예 45의 결과를 나타내며, 11개의 상이한 hGLA DNA 벡터를 동시에 테스트하는 것을 설명하며, 시간 경과에 따라 다양한 혈청 수준을 생성함을 보여준다.
도 90은 실시예 46의 결과를 나타내며, Fc-변형된 GLA가 벡터 주입 후 104일에 심장 조직에서 치료 수준으로 발현될 수 있음을 보여준다.
도 91은 실시예 47의 결과를 나타내며, GLA-Fc 발현에 대한 다양한 돌연변이 Fc 영역의 발현을 비교한다.
도 92는 실시예 48의 결과를 나타내며, 저용량 덱사메타손 전처리의 사용이 단백질 발현 내구성의 지속성을 방해하지 않는다는 것을 설명한다(급성 발현이 증가될 수 있다).
도 1은 4개의 상이한 항체 또는 항체 단편(항-IL5; 5J8 항-플루; 항-SARS-CoV-2; 및 항-CD20)에 대한 36일에 걸쳐 발현 수준을 보여주는 실시예 1의 결과를 보여준다.
도 2는 항-SARS-CoV-2 항체에 대한 43일에 걸쳐 발현 수준과 항-IL5, 5J8 항-flu 및 항-Sars-Cov2에 대한 발현 데이터를 보여주는 실시예 2의 결과를 보여준다.
도 3a는 다수의 독특한 모노클로날 항체의 발현 수준을 보여주는 실시예 3의 결과를 보여준다. 도 3b는 초기 주입 후 29일에 걸쳐 다양한 시점에서 항체의 발현 수준을 보여주는 실시예 3의 결과를 보여준다.
도 4는 주입 후 특정 일자에 항체의 발현 수준을 보여주는 실시예 4의 결과를 보여준다.
도 5a는 15일에 걸쳐 다양한 단백질의 발현 수준을 보여주는 실시예 5의 결과를 보여준다. 도 5b는 22일에 걸쳐 다양한 단백질의 발현 수준을 보여주는 실시예 5의 결과를 보여준다.
도 6은 22일에 걸쳐 다양한 항체의 발현 수준을 보여주는 실시예 6의 결과를 보여준다.
도 7은 다양한 단백질의 발현 수준을 보여주는 실시예 7의 결과를 보여준다.
도 8a 및 8b는 9일에 걸쳐 cDNA-암호화된 재조합 ACE2 단백질의 발현 수준을 보여주는 실시예 8의 결과를 보여준다.
도 9는 인간 ACE2 및 이의 변이체의 발현 수준을 보여주는 실시예 9의 결과를 보여준다.
도 10은 플라스미드 070120 # 1 : B38-람다-BV3 (서열번호: 10)에 대한 핵산 서열을 보여준다.
도 11은 플라스미드 070120 # 11 : B38H-B38L-BV3: 이중 (서열번호: 11)에 대한 핵산 서열을 보여준다.
도 12은 플라스미드 070320 # 4 : B38-카파-BV3 (서열번호: 12)에 대한 핵산 서열을 보여준다.
도 13은 플라스미드 071320 # 3 : H4-카파-BV3 (서열번호: 13)에 대한 핵산 서열을 보여준다.
도 14은 플라스미드 080920 # 6 : H4-H4-카파-BV3 (서열번호: 14)에 대한 핵산 서열을 보여준다.
도 15은 플라스미드 072620 # 5A : 4A8-BV3 (서열번호: 15)에 대한 핵산 서열을 보여준다.
도 16은 플라스미드 081820 # 2 : 4A8-4A8-BV3 (서열번호: 16)에 대한 핵산 서열을 보여준다.
도 17은 플라스미드 081820 # 3 : 4A8-B38카파-BV3 (서열번호: 17)에 대한 핵산 서열을 보여준다.
도 18은 플라스미드 081820 # 4 : 4A8-H4-BV3 (서열번호: 18)에 대한 핵산 서열을 보여준다.
도 19은 플라스미드 081820 # 5 : 4A8-shACE2-BV3 (서열번호: 19)에 대한 핵산 서열을 보여준다.
도 20은 플라스미드 080420 # 3 : shACE2-BV3 (서열번호: 20)에 대한 핵산 서열을 보여준다.
도 21은 플라스미드 082020 # 1 : shACE2 TYLTNY-BV3 (서열번호: 21)에 대한 핵산 서열을 보여준다.
도 22은 플라스미드 081320 # 2A : shACE2-1xL-Fc-BV3(서열번호: 22)에 대한 핵산 서열을 보여준다.
도 23은 플라스미드 081320 # 4A : shACE2-1xL-FcLALA-BV3 (서열번호: 23)에 대한 핵산 서열을 보여준다.
도 24은 플라스미드 082620 # 5A : shACE2 TYLTNY-1xL-FcLALA-BV3 (서열번호: 24)에 대한 핵산 서열을 보여준다.
도 25은 플라스미드 080420 # 4 : shACE2-shACE2-BV3 (서열번호: 25)에 대한 핵산 서열을 보여준다.
도 26은 플라스미드 081120 # 1 : B38카파-shACE2-BV3 (서열번호: 26)에 대한 핵산 서열을 보여준다.
도 27은 플라스미드 081120 # 4 : shACE2-B38카파-BV3 (서열번호: 27)에 대한 핵산 서열을 보여준다.
도 28은 플라스미드 081120 # 2 : H4-shACE2-BV3 (서열번호: 28)에 대한 핵산 서열을 보여준다.
도 29은 플라스미드 081120 # 5 : shACE2-H4-BV3 (서열번호: 29)에 대한 핵산 서열을 보여준다.
도 30은 플라스미드 072320 # 2 : H4-aCD20-aIL5-5J8-BV2 (서열번호: 30)에 대한 핵산 서열을 보여준다.
도 31은 플라스미드 070620 # 2 : B38 람다-aCD20(Cys)-BV3(서열번호: 31)에 대한 핵산 서열을 보여준다.
도 32은 플라스미드 120717 # 1 : aCD20-aIL5-5J8-BV2 (서열번호: 32)에 대한 핵산 서열을 보여준다.
도 33은 플라스미드 122019 # 2A : GLA-1xL-hyFc (서열번호: 33)에 대한 핵산 서열을 보여준다.
도 34은 플라스미드 011215 # 7 : hGCSF-BV3 (서열번호: 34)에 대한 핵산 서열을 보여준다.
도 35은 플라스미드 071816 # 1 : (서열번호: 35)에 대한 핵산 서열을 보여준다.
도 36은 플라스미드 072520 # 4: aCD20-aCD20 (서열번호: 36)에 대한 핵산 서열을 보여준다.
도 37은 플라스미드 111517 # 1 : 5J8-5J8: 더블 2A (서열번호: 37)에 대한 핵산 서열을 보여준다.
도 38은 플라스미드111517 # 3 : aIL5-aIL5 : 더블 2A (서열번호: 38)에 대한 핵산 서열을 보여준다.
도 39은 플라스미드 111517 # 19A : 5J8-aIL5 : 이중 2A (서열번호: 39)에 대한 핵산 서열을 보여준다.
도 40은 A) 코돈 최적화 인간 성장 호르몬(hGH1) cDNA(서열번호: 40); B) hGH1-Fc(서열번호: 41); C) 링커 GGGGS(서열번호: 42), 1x링커: GGTGGAGGAGGTAGT(서열번호: 43), 2x링커: GGTGGAGGAGGTAGTGGGGGTGGAGGTTCA(서열번호: 44), 및 3x링커: GGAGGAGGTGGATCAGGTGGAGGAGGTAGTGGGGGTGGAGGTTCA (서열번호: 45); D) Fc(서열번호: 46); E) Fc 사슬A(서열번호: 47); 및 F) Fc 사슬B(서열번호: 48)의 핵산 서열을 보여준다.
도 41은 A) Fc 사슬AB(서열번호: 49); B) Fc-IgG4(서열번호: 50); C) hyFc(서열번호: 51); D) mFc(서열번호: 52); E) GAALIE(서열번호: 53); 및 F) GAALIE-LS(서열번호: 54)의 핵산 서열을 보여준다.
도 42는 A) hGH1-HSA(서열번호: 55); 및 B) HSA-K753P-링커-GH1:(서열번호: 56)의 핵산 서열을 보여준다.
도 43은 A) hGH1-CTP(서열번호: 57); B) CTP-hGH1-CTP(서열번호: 58); C) CTP-hGH1(서열번호: 59); 및 D) XTEN1-hGH1(서열번호: 60)의 핵산 서열을 보여준다.
도 44는 A) XTEN1-hGH1-XTEN2(서열번호: 61); 및 B) hGH1-XTEN2(서열번호: 62)의 핵산 서열을 보여준다.
도 45a는 Fc, 혈청 알부민 또는 Xten을 포함하는 단백질 반감기 연장 DNA 서열에 융합된 야생형 hGH cDNA의 발현이 면역적격 마우스에서 시간 경과에 따라 혈청 hGH 수준을 상당히 증가시킬 수 있음을 보여준다. 도 45b는 생성된 cDNA-암호화된 hGH 단백질이 hGH-조절된 내인성 마우스, IGF-1 단백질의 수준을 적절하게 증가시키기 때문에 완전히 생체활성임을 보여준다. 도 45c는 실시예 10 절차의 절차에서 DNA 벡터의 1회 주입이 야생형 hGH cDNA를 구동하지만 임의의 단백질 반감기 연장 DNA 서열이 결여되어 면역적격 마우스에서 치료 hGH 혈청 수준의 지속적인 생성을 생성할 수 있음을 보여준다.
도 46은 실시예 11의 절차가 Fc, 혈청 알부민 또는 Xten을 포함하는 단백질 반감기 연장 DNA 서열에 융합된 야생형 hGH cDNA를 발현하여 면역적격 마우스에서 시간 경과에 따라 혈청 hGH 수준을 상당히 증가시키는 데 사용될 수 있음을 보여준다.
도 47은 실시예 12의 절차를 사용하여 완전히 면역적격 마우스에 야생형 hGH cDNA를 구동하는 DNA 벡터의 1회 재주입이 초기 HEDGES hGH DNA 벡터 주입에 의해 생성된 혈청 hGH 수준을 상당히 그리고 지속적으로 추가로 증가시킬 수 있음을 보여준다.
도 48은 Fc 영역 단백질에 융합된 hGH의 발현 수준이 hGH의 반감기를 마우스에서 단일 DNA 주입 후 및 적어도 225일까지 연장함을 보여준다.
도 49는 처리로부터 64일까지 Fc 영역 단백질에 융합된 hGH의 발현 수준을 보여준다.
도 50a는 Fc 단백질 반감기 연장 DNA 서열에 융합된 야생형 hGH cDNA를 구동하는 DNA 벡터의 Fc 영역의 선택적 부위-지정 돌연변이유발이 면역적격 마우스에서 생성된 혈청 hGH 수준을 선택적으로 증가시키거나 감소시킬 수 있음을 보여준다. 도 50b는 Fc 단백질 반감기 연장 DNA 서열에 융합된 야생형 hGH cDNA를 구동하는 DNA 벡터의 Fc 영역의 선택적 부위-지정 돌연변이유발이 면역적격 마우스에서 시간 경과에 따라 생성된 혈청 hGH 수준을 선택적으로 증가시킬 수 있음을 보여준다.
도 51은 최적화된 몰 백분율의 덱사메타손 팔미테이트(DexPalm)를 양이온성 리포좀에 혼입시키는 것이 유전자 발현을 추가로 증가시키고 독성을 추가로 감소시킬 수 있음을 보여준다.
도 52는 최적화된 몰 백분율의 덱사메타손 팔미테이트를 양이온성 리포좀에 혼입시키는 것이 유전자 발현을 추가로 증가시키고 독성을 추가로 감소시킬 수 있음을 보여준다.
도 53은 양이온성 리포좀을 주입하기 전에 리포좀에 덱사메타손 팔미테이트의 최적화된 몰 백분율을 사전 주입하면 유전자 발현을 추가로 증가시키고 독성을 추가로 감소시킬 수 있음을 보여준다.
도 54는 양이온성 리포좀에 혼입된 일부 AIL을 주입하면 유전자 발현을 추가로 증가시키고 독성(ALT 수준)을 추가로 감소시킬 수 있음을 보여준다.
도 55는 양이온성 리포좀에 혼입된 특정 AIL을 주입하면 유전자 발현을 추가로 증가시키고 독성(ALT 수준)을 추가로 감소시킬 수 있음을 보여준다.
도 56은 최적화된 몰 백분율의 덱사메타손 팔미테이트를 양이온성 리포좀에 혼입시키는 것이 그렇지 않으면 비효과적인 hG-CSF-DNA 용량 이후에 유전자 발현의 최고 수준을 추가로 증가시킬 수 있음을 보여준다.
도 57은 비강내로 투여된 리포좀의 지질 조성을 선택적으로 변형함으로써 이들 리포좀이 상이한 정도로 폐내 단핵구 및 대식세포를 선택적으로 표적화하여 폐를 선택적으로 면역-조절할 수 있음을 보여준다.
도 58은 비경구 수용성 예비-투여량 및/또는 후속 투여된 리포좀에 혼입된 덱사메타손 팔미테이트의 몰 백분율을 선택적으로 변형함으로써, 폐 및 혈액 모두에서 T 림프구 활성화 수준이 선택적으로 면역-조절될 수 있음을 보여준다.
도 59는 비경구 수용성 예비-투여량 및/또는 후속 투여된 리포좀에 혼입된 덱사메타손 팔미테이트의 몰 백분율을 선택적으로 변형함으로써, 폐 및 혈액 모두에서 T 림프구 활성화 수준이 선택적으로 면역-조절될 수 있음을 보여준다.
도 60은 항-TNF 모노클로날 항체의 사전투여가 유전자 발현을 추가로 증가시키면서 독성을 추가로 감소시킬 수 있음을 보여준다.
도 61은 NSH의 사전 또는 사후 투여가 독성을 감소시킬 수 있음을 보여준다.
도 62는 NSH의 사전 또는 사후 투여가 독성을 감소시킬 수 있음을 보여준다.
도 63은 NSH의 사전 투여가 독성을 추가로 줄이면서 유전자 발현을 추가로 증가시킬 수 있음을 보여준다.
도 64는 덱사메타손 팔미테이트를 함유하는 리포좀의 다양한 제형의 투여가 덱사메타손 단독의 전신 투여와 비교하여 혈중 림프구 수를 감소시킨다는 것을 보여준다.
도 65는 덱사메타손 팔미테이트를 함유하는 리포좀의 다양한 제형의 투여가 덱사메타손 단독의 전신 투여와 비교하여 혈중 단핵구 수를 감소시킨다는 것을 보여준다.
도 66은 실시예 22의 결과를 보여주며, 이는 5개의 상이한 SARS-CoV2 특이적 mAb(C135, C215, COV2-2355, CV07-209 및 C121) 중 하나를 각각 암호화하는 상이한 단일 DNA 발현 플라스미드의 1회 주입이 투여 후 적어도 134일의 전체 실험 과정 동안 각 SARS-CoV2 특이 mAb의 완전 중화 혈청 수준을 생성하고 이러한 진행 중인 혈청 mAb 수준이 기능적으로 지속적으로 SARS-CoV2 스파이크 - 인간 ACE2 결합을 적어도 120일 동안 차단함을 보여준다.
도 67은 실시예 23의 결과를 보여주며, 단일 주입으로 이 절차 후 적어도 134일 동안 단일 플라스미드로부터 2개의 SARS-CoV2 특이적 mAb가 발현되고 이러한 혈청 발현 mAb 혈청이 적어도 134일 동안 SARS-CoV2 스파이크 - 인간 ACE2 상호작용을 기능적으로 차단할 수 있음을 보여준다.
도 68은 실시예 24의 결과를 보여주며, 3가지 접근 방식을 성공적으로 사용하여 시도된 3가지 접근법에 의해 2개의 항-SARS-CoV2 mAb가 동시에 발현되었음을 보여준다. 3가지 접근법 모두 SARS-CoV2/ACE2 상호작용의 중화를 허용하는 수준(도 68b는 발현 수준을 보여준다)에서 동물의 혈청에서 2개의 mAb의 발현을 성공적으로 허용한다(도 68b는 중화 능력을 보여준다).
도 69는 실시예 25의 결과를 보여주며, 총 3개의 서로 상이한 개별 SARS-CoV2 특이적 mAb를 암호화하는 1개 또는 2개의 DNA 발현 플라스미드를 매주 2회 주입하면 투여 후 적어도 70일의 과정 동안 3개의 상이한 SARS-CoV 2-특이적 mAb의 완전 중화 혈청 수준을 생성하고 이러한 진행 중인 혈청 mAb 수준이 기능적으로 지속적으로 SARS-CoV2 스파이크 - 인간 ACE2를 적어도 70일 동안 차단함을 보여준다.
도 70은 실시예 26의 결과를 보여주며, 이는 마우스에서 발현된 4개의 항-SARS-CoV-2 항체의 발현 수준 및 중화 능력을 보여준다.
도 71은 실시예 27의 결과를 보여주며, 이는 마우스에서 발현된 4개의 항-SARS-CoV-2 항체의 발현 수준 및 중화 능력을 보여준다.
도 72은 실시예 28의 결과를 보여주며, 이는 마우스에서 발현된 4개의 항-SARS-CoV-2 항체의 발현 수준 및 중화 능력을 보여준다.
도 73은 실시예 29의 결과를 보여주며, 이는 마우스에서 발현된 4개의 항-SARS-CoV-2 항체의 발현 수준 및 중화 능력을 보여준다.
도 74은 실시예 30의 결과를 보여주며, 이는 마우스에서 발현된 4개의 항-SARS-CoV-2 항체의 발현 수준 및 중화 능력을 보여준다.
도 75은 실시예 31의 결과를 보여주며, 이는 마우스에서 발현된 5개의 항-SARS-CoV-2 항체의 발현 수준 및 중화 능력을 보여준다.
도 76은 실시예 32의 결과를 보여주며, 이는 마우스에서 발현된 6개의 항-SARS-CoV-2 항체의 발현 수준 및 중화 능력을 보여준다.
도 77은 실시예 33의 결과를 보여주며, 이는 마우스에서 발현된 6개의 항-SARS-CoV-2 항체의 발현 수준 및 중화 능력을 보여준다.
도 78은 실시예 34의 결과를 보여주며, 이는 마우스에서 발현된 6개의 항-SARS-CoV-2 항체의 발현 수준 및 중화 능력을 보여준다.
도 79은 실시예 35의 결과를 보여주며, 이는 마우스에서 발현된 8개의 항-SARS-CoV-2 항체의 발현 수준 및 중화 능력을 보여준다.
도 80은 실시예 36의 결과를 보여주며, 이는 마우스에서 발현된 8개의 항-SARS-CoV-2 항체의 발현 수준 및 중화 능력을 보여준다.
도 81은 실시예 37의 결과를 보여주며, 이는 마우스에서 발현된 8개의 항-SARS-CoV-2 항체의 발현 수준 및 중화 능력을 보여준다.
도 82은 실시예 38의 결과를 보여주며, 이는 마우스에서 발현된 8개의 항-SARS-CoV-2 항체의 발현 수준 및 중화 능력을 보여준다.
도 83은 실시예 39의 결과를 보여주며, 이는 마우스에서 발현된 10개의 항-SARS-CoV-2 항체의 발현 수준 및 중화 능력 뿐만 아니라 다른 비-Sars-CoV-2 항체 및 다양한 치료 단백질의 발현 수준을 보여준다.
도 84은 실시예 40의 결과를 보여주며, 이는 마우스에서 발현된 11개의 항-SARS-CoV-2 항체의 발현 수준 및 중화 능력 뿐만 아니라 다른 비-Sars-CoV-2 항체 및 다양한 치료 단백질의 발현 수준을 보여준다.
도 85은 실시예 41의 결과를 보여주며, 이는 마우스에서 발현된 10개의 항-SARS-CoV-2 항체의 발현 수준 및 중화 능력 뿐만 아니라 다른 비-Sars-CoV-2 항체 의 발현 수준을 보여준다.
도 86a는 실시예 42로부터의 결과를 나타내며, 이는 1-48시간에 걸쳐 지시된 mAb의 발현 수준을 보여준다. 도 86b는 1-48시간의 기간에 걸쳐 지시된 mAb의 중화 능력을 보여준다.
도 87은 실시예 43의 결과를 나타내며, 단일 주입을 사용한 6개의 상이한 mAb 및 유전자의 동시 발현을 기술한다.
도 88은 실시예 44의 결과를 나타내며, 120일에 걸쳐 표적 유전자(인간 성장 호르몬)를 발현하기 위한 다양한 진핵 프로모터의 사용을 기술한다.
도 89는 실시예 45의 결과를 나타내며, 11개의 상이한 hGLA DNA 벡터를 동시에 테스트하는 것을 설명하며, 시간 경과에 따라 다양한 혈청 수준을 생성함을 보여준다.
도 90은 실시예 46의 결과를 나타내며, Fc-변형된 GLA가 벡터 주입 후 104일에 심장 조직에서 치료 수준으로 발현될 수 있음을 보여준다.
도 91은 실시예 47의 결과를 나타내며, GLA-Fc 발현에 대한 다양한 돌연변이 Fc 영역의 발현을 비교한다.
도 92는 실시예 48의 결과를 나타내며, 저용량 덱사메타손 전처리의 사용이 단백질 발현 내구성의 지속성을 방해하지 않는다는 것을 설명한다(급성 발현이 증가될 수 있다).
정의
본원에서 사용되는 "CpG-감소된"이라는 어구는 서열 또는 벡터의 야생형 버전에 존재하는 것보다 더 적은 CpG 디뉴클레오티드를 갖는 핵산 서열 또는 발현 벡터를 지칭한다. "CpG-무함유"는 해당 핵산 서열 또는 벡터에 CpG 디뉴클레오티드가 없음을 의미한다. CpG 디뉴클레오티드(예를 들어, 항-SARS-CoV-2 항체의 야생형 버전)를 함유하는 초기 서열은 핵산 서열을 변경하여 CpG 디뉴클레오티드를 제거하도록 변형될 수 있다. 이러한 CpG 디뉴클레오티드는 코딩 서열 뿐만 아니라 예를 들어 5' 및 3' 비번역 영역(UTR), 프로모터, 인핸서, 폴리A, ITR, 인트론 및 핵산 분자 또는 벡터에 존재하는 다른 서열을 포함하는 비-코당 서열에서 적절하게 감소되거나 제거될 수 있다. 특정 구현양태에서, 본원에 사용된 핵산 서열은 CpG-감소되거나 CpG-무함유이다.
본원에서 사용되는 바와 같이, "빈 리포좀"은 핵산 분자를 함유하지 않지만 다른 생리활성 분자를 함유 수 있는 리포좀을 의미한다(예를 들어, 지질 분자 자체로만 구성된 리포좀, 또는 지질 분자 및 소분자 약물만으로 구성된 리포좀). 특정 구현양태에서, 빈 리포좀은 본원에 개시된 임의의 방법 또는 조성물과 함께 사용된다.
본원에서 사용된 바와 같이, "빈 양이온성 미셀"은 핵산 분자를 함유하지 않지만 다른 생체활성 분자를 포함할 수 있는 양이온성 미셀(예를 들어, 지질 및 계면활성제 분자 자체로만 구성된 미셀 또는 지질 및 계면활성제 분자와 저분자 약물로만 구성된 미셀). 특정 구현양태에서, 빈 양이온성 미셀은 본원에 개시된 임의의 방법 또는 조성물과 함께 사용된다.
본원에서 사용되는 "빈 양이온성 에멀젼"은 핵산 분자를 함유하지 않지만 다른 생체활성 분자를 함유할 수 있는 양이온성 에멀젼 또는 마이크로-에멀젼을 의미한다. 특정 구현양태에서, 빈 양이온성 에멀젼은 본원에 개시된 임의의 방법 또는 조성물과 함께 사용된다.
본원에 사용된 용어 "알킬"은 1 내지 30개의 탄소 원자, 예를 들어 1 내지 16개의 탄소 원자(C1-C16 알킬), 1 내지 14개의 탄소 원자(C1-C14 알킬), 1 내지 12개의 탄소 원자(C1-C12 알킬), 1 내지 10개의 탄소 원자(C1-C10 알킬), 1 내지 8개의 탄소 원자(C1-C8 알킬), 1 내지 6개의 탄소 원자(C1-C6 알킬), 1 내지 4개의 탄소 원자(C1-C4 알킬) 또는 5 내지 23개의 탄소 원자(C5-C23 알킬)를 함유하는 직쇄 또는 분지쇄 포화 탄화수소를 의미한다. 알킬의 대표적인 예는 메틸, 에틸, n-프로필, 이소-프로필, n-부틸, sec-부틸, 이소-부틸, tert-부틸, n-펜틸, 이소펜틸, 네오펜틸, n-헥실, 3-메틸헥실, 2,2-디메틸펜틸, 2,3-디메틸펜틸, n-헵틸, n-옥틸, n-노닐, n-데실, n-운데실 및 n-도데실을 포함하지만 이에 제한되지 않는다.
본원에 사용된 용어 "알케닐"은 2 내지 30개의 탄소 원자를 함유하고 적어도 하나의 탄소-탄소 이중 결합, 예를 들어 2 내지 16개의 탄소 원자(C2-C16 알킬), 2 내지 14개의 탄소 원자(C2-C14 알킬), 2 내지 12개의 탄소 원자(C2-C12 알킬), 2 내지 10개의 탄소 원자(C2-C10 알킬), 2 내지 8개의 탄소 원자(C2-C8 알킬), 2 내지 6개의 탄소 원자(C2-C6 알킬), 2 내지 4개의 탄소 원자(C2-C4 알킬), 또는 5 내지 23개의 탄소 원자(C5-C23 알킬) 함유하는 직쇄 또는 분지쇄 탄화수소 사슬을 지칭한다. 알케닐의 대표적인 예는 에테닐, 2-프로페닐, 2-메틸-2-프로페닐, 3-부테닐, 4-펜테닐, 5-헥세닐, 2-헵테닐, 2-메틸-1-헵테닐, 및 3-데세닐을 포함하지만 이에 제한되지 않는다.
본 명세서에서 "대상체" 및 "환자"라는 용어는 개, 고양이, 새, 가축과 같은 포유동물, 바람직하게는 인간과 같은 모든 동물을 의미한다.
본원에서 사용되는 바와 같이, 용어 "투여"는 본원에 기술된 바와 같은 조성물을 대상체에게 제공하는 행위를 의미한다. 인체에 대한 예시적인 투여 경로는 입(경구), 피부(경피, 국소), 코(비강), 폐(흡입제), 구강 점막(구강), 주입(예를 들어, 정맥내, 피하, 종양내, 안구 내, 복강 내 등) 등 일 수 있다.
본 발명은 대상체에서 적어도 하나의 치료 단백질 또는 생물학적 활성 핵산 분자를 발현하기 위한 조성물, 시스템, 키트 및 방법을 제공한다. 특정 구현양태에서, 대상체는 먼저 핵산 분자가 없거나 또는 본질적으로 없는 다가양이온성 구조를 포함하는 조성물을 투여받은 다음(예를 들어, 1-30분 후) 적어도 하나의 치료 단백질(예를 들어, 적어도 하나의 항-SARS-CoV-2 항체, 다중 상이한 항체, 적어도 하나의 재조합 ACE2 또는 인간 성장 호르몬)을 암호화하는 다수의 하나 이상의 비-바이러스 발현 벡터를 포함하는 조성물 또는 생물학적 활성 핵산 분자를 포함하는 조성물을 투여받는다. 일부 구현양태에서, 대상체에서 발현 수준 및/또는 길이를 증가시키는 제제(예를 들어, EPA 또는 DHA)가 추가로 투여된다. 특정 구현양태에서, 제 1 및/또는 제 2 조성물은 대상체의 기도를 통해 투여된다.
본 개시내용은 양이온성 리포좀의 단일 주입(예를 들어, 정맥내 주입), 그 직후 적어도 하나의 단백질 또는 생물학적 활성 핵산 분자를 암호화하는 벡터의 주입(예를 들어, 정맥내 주입)하여, 다른 접근 방식보다 순환 단백질 수준(예를 들어, 190일 또는 500일 이상의 장기간 발현 가능)을 여러 배(예를 들어, 2-20배 더 높음) 생산하게 하는 하는 방법, 시스템 및 조성물을 제공한다.
특정 구현양태에서, 본 개시내용은 벡터 투여 전에 대상체에게 투여되는 벡터 DNA를 함유하지 않는 다가양이온성 구조(예를 들어, 빈 양이온성 리포좀, 빈 양이온성 미셀 또는 빈 양이온성 에멀젼)를 사용한다. 특정 구현양태에서, 다가양이온성 구조는 양이온성 지질이고/이거나 에멀젼으로서 제공된다. 본 개시내용은 사용된 양이온성 지질에 제한되지 않으며, 이는 일부 구현양태에서 하기 중 하나 이상으로 구성될 수 있다: DDAB, 디메틸디옥타데실 암모늄 브로마이드; DPTAP(1,2-디팔미토일 3-트리메틸암모늄 프로판); DHA; 프로스타글란딘, N-[1-(2,3-디올로일옥시)프로필]-N,N,N--트리메틸암모늄 메틸설페이트; 1,2-디아실-3-트리메틸암모늄-프로판(디올레오일(DOTAP), 디미리스토일, 디팔미토일, 디세아로일을 포함하나 이에 제한되지 않는); 1,2-디아실-3-디메틸암모늄-프로판(디올레오일, 디미리스토일, 디팔미토일, 디세아로일을 포함하나 이에 제한되지 않는) DOTMA, N-[1-[2,3-비스(올레오일옥시)]프로필]-N,N,N-트리메틸암모늄-m 클로라이드; DOGS, 디옥타데실아미도글리실스페민; DC-콜레스테롤, 3.베타.-[N-(N',N'-디메틸아미노에탄)카바모일]콜레스테롤; DOSPA, 2,3-디올레오일옥시-N-(2(스페르민카복스아미도)-에틸)-N,N-디메틸-1-프로파나미늄 트리플루오로아세테이트; 1,2-디아실-sn-글리세로-3-에틸포스포콜린(디올레오일(DOEPC), 디라우로일, 디미리스토일, 디팔미토일, 디스테아로일, 팔미토일-올레오일을 포함하나 이에 제한되지 않는); 베타-알라닐 콜레스테롤; CTAB, 세틸 트리메틸 암모늄 브로마이드; 디C14-아미딘, N-t-부틸-N'-테트라데실-3-테트라데실아미노프로피온아미딘; 14Dea2, O,O'-디테트라데카놀릴-N-(트리메틸암모니오아세틸)디에탄올아민 클로라이드; DOSPER, 1,3-디올레오일옥시-2-(6-카복시-스페르밀)-프로필아미드; N,N,N',N'-테트라메틸-N,N'-비스(2-히드록실에틸)-2,3-디올레오일옥시-1,4-부탄디암모늄 요오다이드; 1-[2-아실옥시)에틸]2-알킬(알케닐)-3-(2-히드록시에틸-)이미다졸리늄 클로라이드 유도체, 예컨대 1-[2-(9(Z)-옥타데세노일옥시)에틸]-2-(8(Z)-헵타데세닐-3-(2-히드록시에틸)이미다졸리늄 클로라이드(DOTIM), 1-[2-(헥사데카노일옥시)에틸]-2-펜타데실-3-(2-히드록시에틸)이미다졸리늄 클로라이드(DPTIM); 1-[2-테트라데카노일옥시)에틸]-2-트리데실-3-(2-히드록시에틸)이미다졸륨 클로라이드(DMTIM)(Solodin et al. (1995) Biochem. 43:13537-13544, 본원에 참조로 포함); 1,2-디올레오일-3-디메틸-히드록시에틸 암모늄 브로마이드(DORI)와 같은 4급 아민 상에 히드록시알킬 모이어티를 함유하는 2,3-디알킬옥시프로필 4급 암모늄 화합물 유도체; 1,2-디올레일옥시프로필-3-디메틸-히드록시에틸 암모늄 브로마이드(DORIE); 1,2-디올레일옥시프로필-3-디메틸-히드록시프로필 암모늄 브로마이드(DORIE-HP), 1,2-디올레일옥시프로필-3-디메틸-히드록시부틸 암모늄 브로마이드(DORIE-HB); 1,2-디올레일옥시프로필-3-디메틸-히드록시펜틸 암모늄 브로마이드(DORIE-HPe); 1,2-디미리스틸옥시프로필-3-디메틸-히드록실에틸 암모늄 브로마이드(DMRIE); 1,2-디팔미틸옥시프로필-3-디메틸-히드록시에틸 암모늄 브로마이드(DPRIE); 1,2-디스테릴옥시프로필-3-디메틸-히드록시에틸 암모늄 브로마이드(DSRIE)(Felgner et al.(1994) J. Biol. Chem. 269:2550-2561, 그 전체 내용이 참조로 본원에 포함). 상기 언급된 많은 지질은 상업적으로 구입가능하다(Avanti Polar Lipids, Inc.; Sigma Chemical Co.; Molecular Probes, Inc.; Northern Lipids, Inc.; Roche Molecular Biochemicals; and Promega Corp).
특정 구현양태에서, 방법, 조성물, 시스템 및 키트와 함께 사용되는 중성 지질은 디아실글리세로포스포릴콜린을 포함하며, 여기서 아실 사슬은 일반적으로 길이가 적어도 12개 탄소(예를 들어, 12...14...20...24...또는 그 이상의 탄소 길이)이며, 하나 이상의 시스 또는 트랜스 이중 결합을 포함할 수 있다. 상기 화합물의 예는 디스테아로일 포스파티딜 콜린(DSPC), 디미리스토일 포스파티딜콜린(DMPC), 디팔미토일 포스파티딜콜린(DPPC), 팔미토일 올레오일 포스파티딜콜린(POPC), 팔미토일 스테아로일 포스파티딜콜린(PSPC), 계란 포스파티딜콜린(EPC), 수소화 또는 비수소화 대두 포스파티딜콜린(HSPC) 또는 해바라기 포스파티딜콜린을 포함하나 이에 제한되지 않는다.
특정 구현양태에서, 중성 지질은, 예를 들어 최대 70 mol 디아실글리세로포스포릴에탄올아민/100 mol 인지질(예를 들어, 10/100 mol … 25/100 mol … 50/100 … 70/100 mol)을 포함한다. 일부 구현양태에서, 디아실글리세로포스포릴에탄올아민은 일반적으로 탄소 길이가 적어도 12개(예를 들어, 탄소 길이가 12...14...20...24...또는 그 이상)인 아실 사슬을 갖고, 하나 이상의 시스 또는 트랜스 이중 결합을 함유할 수 있다. 이러한 화합물의 예는 디스테아로일포스파티딜에탄올아민(DSPE), 디미리스토일포스파티딜에탄올아민(DMPE), 디팔미토일포스파티딜에탄올아민(DPPE), 팔미토일올레오일포스파티딜에탄올아민(POPE), 계란 포스파티딜에탄올아민(EPE) 및 트랜스포스파티딜화 포스파티딜에탄올아민(t-EPE)을 포함하지만 이에 제한되지 않고, 포스포리파제 D를 사용하여 다양한 천연 또는 반합성 포스파티딜콜린으로부터 생성될 수 있다.
특정 구현양태에서, 본 개시내용은 CpG-감소된 또는 CpG-무함유 발현 벡터를 사용한다. CpG 디뉴클레오티드(예를 들어, 항-SARS-CoV-2 항체의 야생형 버전)를 포함하는 초기 서열은 핵산 서열을 변경하여 CpG 디뉴클레오티드를 제거하도록 변형될 수 있다. 이러한 CpG 디뉴클레오티드는 코딩 서열 뿐만 아니라 예를 들어 5' 및 3' 비번역 영역(UTR), 프로모터, 인핸서, 폴리A, ITR, 인트론 및 핵산 분자 또는 벡터에 존재하는 다른 서열에서 적절하게 감소되거나 제거될 수 있다. CpG 디-뉴클레오티드는 선택된 아미노산에 대한 코돈 삼중항 내에 위치할 수 있다. CpG 디뉴클레오티드를 함유하는 하나 이상의 코돈 삼중항을 갖는 5개의 아미노산(세린, 프롤린, 트레오닌, 알라닌 및 아르기닌)이 있다. 이들 5개의 아미노산 모두는 CpG를 피하기 위해 변경될 수 있는 CpG 디뉴클레오티드를 함유하지 않는 대체 코돈을 갖지만 여전히 하기 표 1에 나타낸 바와 같은 동일한 아미노산을 암호화한다. 따라서, 선택된 아미노산에 대한 코돈 삼중항 내에 할당된 CpG 디뉴클레오티드는 CpG 디뉴클레오티드가 결여된 동일한 아미노산에 대한 코돈 삼중항으로 변경될 수 있다.
표 1
또한 코딩 영역 내에서 삼중항 간의 인터페이스를 고려해야 한다. 예를 들어, 아미노산 삼중항이 C-뉴클레오티드로 끝난 다음 G-뉴클레오티드로만 시작할 수 있는 아미노산 삼중항(예를 들어, 발린, 글리신, 글루타민산, 알라닌, 아스파르트산)이 뒤따른다면, 첫 번째 아미노산 삼중항에 대한 삼중항은 C-뉴클레오티드로 끝나지 않는 것으로 변경된다. CpG 없는 서열을 만드는 방법은, 예를 들어 본원에 참조로 포함되는 U.S. 특허 7,244,609에 기재되어 있다. 인비보젠(INVIVOGEN)에서 제공하는 상용 서비스를 통해 CpG가 없는(또는 감소된) 핵산 서열/벡터(플라스미드)를 생산할 수도 있다. 써모사이언티픽(ThermoScientific)에서 제공하는 상용 서비스는 CpG가 없는 뉴클레오티드를 생산한다.
본원에 기재된 벡터에 사용될 수 있는 예시적인 프로모터 및 인핸서가 하기 표 2에 제공된다. 이러한 프로모터 및 당업계에 공지된 다른 프로모터는 단독으로 또는 당업계에 공지된 임의의 인핸서 또는 인핸서와 함께 사용될 수 있다. 추가로, 다중 단백질 또는 생물학적 활성 핵산 분자(예를 들어, 2개, 3개, 4개 또는 그 이상)가 동일한 벡터로부터 발현되는 경우, 대상 핵산 서열과 함께 동일하거나 상이한 프로모터가 사용될 수 있다. 일부 구현양태에서, 하기 목록으로부터 선택된 프로모터는 단백질 또는 핵산의 발현 수준을 제어하기 위해 사용된다: FerL, FerH, Grp78, hREG1B 및 cBOX1. 이러한 프로모터는 예를 들어, 넓은 시간 범위에 걸쳐(예를 들어, 유전자 스위치를 포함하는 임의의 다른 변형을 사용하지 않고) 단백질 생산(예를 들어, HGH)을 제어하기 위해 사용될 수 있다.
표 2
일부 구현양태에서, 본원의 조성물 및 시스템은 적절한 대상체(예를 들어, 마우스, 인간 등)에서 치료 및/또는 예방 효과를 도출하도록 선택된 용량으로 제공 및/또는 투여된다. 일부 구현양태에서, 치료 용량이 제공된다. 일부 구현양태에서, 예방 용량이 제공된다. 용량 및 투여 요법은 원하는 약리 효과 수준, 얻을 수 있는 실제 약리 효과 수준, 독성을 포함하되 이에 제한되지 않는 잘 알려진 약리학적 및 치료적/예방적 고려 사항에 기초하여 임상의 또는 약리학 분야의 다른 숙련가에 의해 조정된다. 일반적으로 약제를 투여하기 위해 잘 알려진 약리학적 원칙을 따르는 것이 바람직하다(예를 들어, 일반적으로 한 번에 50% 이상 용량을 변경하지 않고 매 3-4 제제 반감기를 초과하지 않는 것이 좋다). 용량-관련 독성 고려 사항이 상대적으로 거의 없거나 전혀 없고 최대 효능이 요구되는 조성물의 경우, 필요한 평균 용량을 초과하는 용량이 드문 일이 아니다. 투여량에 대한 이러한 접근법은 일반적으로 "최대 투여량" 전략이라고 한다. 특정 구현양태에서, 용량(예를 들어, 예방적 또는 치료적)은 약 0.01 mg/kg 내지 약 200 mg/kg(예를 들어, 0.01 mg/kg, 0.02 mg/kg, 0.05 mg/kg, 0.1 mg/kg, 0.2 mg/kg, 0.5 mg/kg, 1.0 mg/kg, 2.0 mg/kg, 5.0 mg/kg, 10 mg/kg, 20 mg/kg, 50 mg/kg, 100 mg/kg, 200 mg/kg, 또는 임의의 사이의 범위(예를 들어, 5.0 mg/kg 내지 100 mg/kg))이다. 일부 구현양태에서, 대상체는 0.1 kg(예를 들어, 마우스) 내지 150 kg(예를 들어, 인간), 예를 들어, 0.1 kg, 0.2 kg, 0.5 kg, 1.0 kg, 2.0 kg, 5.0 kg, 10 kg, 20 kg, 50 kg, 100 kg, 200 kg 또는 이들 사이의 임의의 범위(예를 들어, 40-125 kg)이다. 일부 구현양태에서, 용량은 0.001 mg 내지 40,000 mg(예를 들어, 0.001 mg, 0.002 mg, 0.005 mg, 0.01 mg, 0.02 mg, 0.05 mg, 0.1 kg, 0.2 mg, 0.5 mg, 1.0 mg, 2.0 mg, 5.0 mg, 10 mg, 20 mg, 50 mg, 100 mg, 200 mg, 500 mg, 1,000 mg, 2,000 mg, 5,000 mg, 10,000 mg, 20,000 mg, 40,000 mg, 또는 이들 사이의 범위)이다.
특정 구현양태에서, 표적 펩티드는 본원의 조성물에서 양이온성 또는 중성 리포좀과 함께 사용된다. 예시적인 표적 펩티드는 하기 표 3에 제시되어 있다. 표 3에서 "[n]" 접두사는 N-말단을 나타내고 "[c]" 접미사는 C-말단을 나타낸다. 둘 중 하나가 부족한 서열은 단백질 중간에서 발견된다.
표 3
특정 구현양태에서, 하나 이상(예를 들어, 적어도 3개 또는 적어도 8개의 항체)이 본원의 시스템 및 방법으로 발현된다. 일부 구현양태에서, 이는 아래 표 4에 제시된 치료용 모노클로날 항체(mAb), Fab, F(ab)2 및 scFv 뿐만 아니라 본원에 참조로 포함된 표 5 및 표 7에서 제공된 항-SARS-CoV2 항체 및 항원 결합 단편을 포함한다.
표 4
표 5
특정 구현양태에서, 항염증제 또는 생물활성 지질과 같은 제제는 본원의 방법에서 비-바이러스 벡터로부터 발현되는 임의의 치료 단백질(또는 생물학적 활성 핵산 분자)의 발현 수준 및/또는 지속 시간을 증가시키기 위해 사용된다. 구현양태의 개발 중에 수행된 작업에서, 아래 표 6의 항염증제(AIL) 및 생리활성 지질이 테스트되었고, 검은색의 것이 성공적인 제제인 것으로 밝혀졌다.
표 6
실시예
하기 실시예에서, 덱사메타손은 수용성 덱사메타손이며, 가용성이 되도록 시클로덱스트린에 착물화된 덱사메타손을 함유한다. 덱사메타손 팔미테이트는 덱사메타손 21-팔미테이트이다.
실시예 1
다중-MAb 발현
이 실시예는 4주 처리 과정에 걸쳐 마우스에서 일련의 처리 후 다수의 독특한 모노클로날 항체의 생체내 발현을 기술한다.
실험 방법: 0일째, 군당 3마리의 마우스에게 지질(2.5 mol% 덱사메타손 팔미테이트를 갖는 1000 nmol DOTAP SUV 및 5 mol% 덱사메타손 팔미테이트를 갖는 1000 nmol DMPC(1,2-디미리스토일-SN-글리세로-3-포스포콜린) 중성 지질)의 순차적 IV 주입 2시간 전에 덱사메타손(40 mg/kg)을 IP 주입했고, 2시간 후 5J8 및 항-IL5 cDNA("5J8-IL5")를 함유하는 75 mg의 단일 플라스미드 DNA(pDNA)를 투여했다. 이들 마우스를 다시 7일, 14일 및 21일에 이전과 같이 IP 덱사메타손 및 IV 지질 및 순차 pDNA로 재처리했지만, 지시된 용량에서 다음 cDNA를 함유하는 pDNA(들)로 처리하였다: 7일: 88 mg B38-람다 항-CoV2 "B38 람다", 14일: 44 mg B38-람다 항-CoV2 및 2개의 항-IL5 cDNA(IL5-IL5)를 함유하는 단일 pDNA 44 mg, 21일: 44 mg 리툭시맙(aCD20 이중) 및 44 mg H4 항-CoV2("H4"). mAb 단백질의 혈청 수준은 각 처리 후 24시간 및 그 후 2-3주마다 ELISA로 측정했다. 표적 단백질의 군 평균 +/- SEM 혈청 수준이 그래프에 표시된다. 표시된 "주입 후 일" 시점은 모두 0일에 5J8 및 항-IL5 cDNA를 함유하는 pDNA의 초기 주입과 관련된다.
그 결과는 도 1에 나와 있으며, 매주 다른 DNA mAb 벡터를 연속 주입하면 개별 마우스에서 4개의 상이한 온전한 모노클로날 항체의 지속적인 치료 수준을 생성할 수 있음을 보여준다.
실시예 2
다중-MAb 발현
이 실시예는 6주 처리 과정에 걸쳐 마우스에서 일련의 처리 후 다수의 독특한 모노클로날 항체의 생체내 발현을 기술한다.
실험 방법: 0일째, 군당 3마리의 마우스에게 지질(2.5 mol% 덱사메타손 팔미테이트를 포함하는 1000 nmol DOTAP SUV 및 5 mol% 덱사메타손 팔미테이트를 포함하는 1000 nmol DMPC(1,2-디미리스토일-SN-글리세로-3-포스포콜린) 중성 지질)의 순차적 IV 주입 2시간 전에 덱사메타손(40 mg/kg)을 IP 주입했고, 2시간 후 항-IL5 및 5J8 cDNA("aIL5 + 5J8")를 함유하는 44 mg의 pDNA를 투여했다. 이들 마우스를 다시 7일, 14일에 이전과 같이 IP 덱사메타손 및 IV 지질 및 순차 pDNA로 유사하게 재처리했지만, 지시된 용량에서 다음 cDNA를 함유하는 pDNA(들)로 처리하였다: 7일: 75 mg의 항-Sars-Cov-2 모노클로날 항체 B38 카파 cDNA("B38-카파"), 14일: 리툭시맙 cDNA("aCD20-aCD20") 카피 2개를 함유하는 단일 pDNA 44 mg, 및 2개의 5J8 카피("5J8-5J8")을 함유하는 단일 pDNA 44 mg. mAb 단백질의 혈청 수준은 각 처리 후 24시간 및 그 후 1-2주마다 ELISA로 측정했다. 표적 단백질의 군 평균 +/- SEM 혈청 수준이 그래프에 표시된다. 표시된 시점은 모두 0일에 항-IL5 및 5J8 cDNA를 함유하는 pDNA의 초기 주입과 관련된다.
결과는 도 2에 나와 있으며, 매주 상이한 DNA mAb 벡터를 연속 주입하면 개별 마우스에서 4개의 상이한 온전한 모노클로날 항체의 지속적인 치료 수준을 생성할 수 있음을 보여준다.
실시예 3
다중-MAb 발현
이 실시예는 3주 처리 과정에 걸쳐 마우스에서 일련의 처리 후 다수의 독특한 모노클로날 항체의 생체내 발현을 기술한다.
실험 방법:
도 3a와 관련하여: 0일째에, 군당 3마리의 마우스로 이루어진 4개의 군에 지질(2.5 mol% 덱사메타손 팔미테이트를 포함하는 1000 nmol DOTAP SUV 및 5 mol% 덱사메타손 팔미테이트를 포함하는 1000 nmol DMPC(1,2-디미리스토일-SN-글리세로-3-포스포콜린) 중성 지질)의 순차적 IV 주입 2시간 전에 덱사메타손(40 mg/kg)을 IP 주입했고, 2시간 후 다음과 같은 항-Sars-Cov-2 모노클로날 항체 B38 cDNA를 함유하는 4개의 개별 pDNA 중 하나의 75 mg을 투여했다: 군 1: B38-람다-BV3, 군 2: modSE3-2-mCMV-B38-BV3, 군 3: modSE3-2-hCMV-B38-BV3 및 군 4: B38-카파-BV3. 항-CoV2 mAb 단백질의 혈청 수준은 초기 처리 후 24시간에후 ELISA로 측정되었으며 군 평균 +/- SEM으로 표시된다.
도 3b와 관련하여: 이러한 동일한 마우스를 7일 및 14일에 이전과 같이 IP 덱사메타손 및 IV 지질 및 순차적 pDNA로 유사하게 처리했지만, 지시된 용량에서 다음 cDNA를 포함하는 pDNA(들)로 처리했다: 7일: 44 mg 항-IL5 ("aIL5") 및 44 mg 5J8("5J8"). 14일: 88 mg 리툭시맙("aCD20 이중").
항-CoV2 mAb 단백질의 혈청 수준은 초기 치료 후 24시간에 ELISA로 측정하고 그 후 매주 측정했다. 항-IL5, 5J8 및 리툭시맙의 혈청 수준은 22일 및 29일에 측정되었고 군 평균 +/- SEM으로 표시된다. 도 3a 및 3b에 표시된 시점은 모두 0일째에 pDNA-함유 항-IL5 및 5J8 cDNA의 초기 주입에 대한 것이다.
도 3a 및 3b에 표시된 이러한 결과는 A) pDNA 발현 벡터의 다양한 구성으로 인해 표적 단백질의 발현 수준이 서로 다르다는 것과 B) 상이한 mAb 클론을 암호화하는 pDNA mAb 벡터를 연속적으로 주입하면 개별 마우스에서 4가지 상이한 온전한 모노클로날 항체의 상당한 진행 중인 혈청 수준을 생산할 수 있다는 것을 보여준다.
실시예 4
다중-MAb 발현
이 실시예는 3주 처리 과정에 걸쳐 마우스에서 일련의 처리 후 다수의 독특한 모노클로날 항체의 생체내 발현을 기술한다.
실험 방법: 0일째에, 군당 3마리의 마우스로 이루어진 3개의 군에 지질(2.5 mol% 덱사메타손 팔미테이트를 포함하는 1000 nmol DOTAP SUV 및 5 mol% 덱사메타손 팔미테이트를 포함하는 1000 nmol DMPC(1,2-디미리스토일-SN-글리세로-3-포스포콜린) 중성 지질)의 순차적 IV 주입 2시간 전에 덱사메타손(40 mg/kg)을 IP 주입했고, 지시된 용량으로 다음의 cDNA를 포함하는 다음 pDNA(들)를 투여했다: 5J8 cDNA 2개 카피("5J8-5J8")를 포함하는 단일 pDNA 44 mg 및 항-IL5 cDNA 2개 카피("aIL5-aIL5")를 포함하는 단일 pDNA 44 mg. 이들 동일한 군의 마우스를 7일, 14일에 전과 같이 IP 덱사메타손 및 IV 지질 및 순차적인 pDNA로 처리했지만, 지시된 용량에서 다음 cDNA를 함유하는 pDNA(들)로 처리하였다: 군 1: 7일 - 리툭시맙 cDNA("aCD20-이중") 44 mg 및 B38 항-SARS CoV2 cDNA("B38-Tag") 44 mg, 14일 - 항-Sars-Cov-2 모노클로날 항체("H4") 88 mg. 군 2: 7일 - 리툭시맙 cDNA("aCD20-aCD20") 2개 카피를 포함하는 단일 pDNA 44 mg 및 항-Sars-Cov-2 모노클로날 항체 B38 카파 cDNA("B38-카파") cDNA("B38-태그") 44 mg, 14일 - 항-Sars-Cov-2 모노클로날 항체 H4 cDNA("H4") 88 mg. 군 3: 7일 - 리툭시맙 cDNA("aCD20-dual") 44 mg 및 B38 항-SARS CoV2 cDNA("B38-태그") 44 mg, 14일 - 치료 없음.
mAb 단백질의 혈청 수준은 1일, 8일, 및 15일에 ELISA로 측정했다. 표시된 시점은 모두 5J8 및 aIL5 cDNA를 함유하는 pDNA의 초기 주입과 관련이 있다. 결과는 도 4에 나와 있으며, 매주 상이한 DNA mAb 벡터를 연속 주입하면 개별 마우스에서 4개의 상이한 온전한 모노클로날 항체의 지속적으로 유의미한 혈청 수준을 생성할 수 있음을 보여준다.
실시예 5
다중 단백질 발현
이 실시예는 3주 처리 과정에 걸쳐 마우스에서 일련의 처리 후 다수의 독특한 모노클로날 항체의 생체내 발현을 기술한다.
실험 방법:
도 5a와 관련하여: 0일째에, 군당 3마리의 마우스로 이루어진 8개의 군에 지질(2.5 mol% 덱사메타손 팔미테이트를 포함하는 1000 nmol DOTAP SUV 및 5 mol% 덱사메타손 팔미테이트를 포함하는 1000 nmol DMPC(1,2-디미리스토일-SN-글리세로-3-포스포콜린) 중성 지질)의 순차적 IV 주입 2시간 전에 덱사메타손(40 mg/kg)을 IP 주입했고, 지시된 용량의 다음의 cDNA를 포함하는 다음 pDNA(들)를 투여했다: 군 1: 리툭시맙, 항-IL5 및 5J8 cDNA("maCD20-haIL5-m5J8")를 암호화하는 단일 pDNA 88 mg; 군 2: 항-SARS-Cov-2 모노클로날 항체 B38 람다 cDNA("B38-카파"), 리툭시맙, 항-IL5 및 5J8 cDNA("mB38Ld-maCD20-haIL5-m5J8")를 암호화하는 단일 pDNA 88 mg; 군 3: 항-Sars-Cov-2 모노클로날 항체 H4 cDNA("mH4"), 리툭시맙, 항-IL5 및 5J8 cDNA("mH4-maCD20-haIL5-m5J8")를 암호화하는 단일 pDNA 88 mg; 군 4: 항-Sars-Cov-2 모노클로날 항체 B38 카파 cDNA("B38-카파") 및 항-IL5 cDNA("mB38Kp-haIL5")를 암호화하는 단일 pDNA 88 mg; 군 5: 항-Sars-Cov-2 모노클로날 항체 B38 카파 cDNA("B38-카파") 및 5J8 cDNA("mB38Kp-m5J8")를 암호화하는 단일 pDNA 88 mg; 군 6: 항-Sars-Cov-2 모노클로날 항체 B38 람다 cDNA("B38-람다") 및 항-IL5 cDNA("mB38Ld-maIL5")를 암호화하는 단일 pDNA 88 mg; 군 7: 항-Sars-Cov-2 모노클로날 항체 B38 람다 cDNA 및 5J8 cDNA("mB38Ld-m5J8")를 암호화하는 단일 pDNA 88 mg; 군 8: 항-IL5 및 B38 람다 cDNA("maIL5-mB38Ld")를 암호화하는 단일 pDNA 88 mg. 이들 동일한 마우스 군 중 일부를 7일 및/또는 14일에 이전과 같이 IP 덱사메타손 및 IV 지질 및 순차적인 pDNA로 재처리했지만, 지시된 용량에서 다음 cDNA를 함유하는 pDNA(들)로 재처리하였다:
군 1: 7일 - 44 mg 리툭시맙("aCD20-이중") 및 항-SARS-CoV2 mAb H4를 함유하는 단일 pDNA 44 mg, 14일 - 치료 없음. 군 2: 7일 - 치료 없음, 14일 - 치료 없음. 군 3, 4: 7일 - 44 mg 리툭시맙("aCD20-이중") 및 2개 카피의 5J8 cDNA("5J8-5J8")를 함유하는 단일 pDNA 44 mg, 14일 - 44 mg 인간 G-CSF("GCSF") 및 44 mg 인간 알파-글락토시다제 A("GLA")("hGLA-hyFc"), 21일 - 44 mg 인간 Ace2("hACE2") 및 44 mg 인간 성장 호르몬("hGH")("hGH-Fc"). 군 5: 7일 - 44 mg 리툭시맙("aCD20-이중") 및 항-IL5 cDNA의 2개 카피("aIL5-aIL5")를 포함하는 단일 pDNA 44 mg, 14일 - 44 mg GCSF("GCSF") 및 44 mg GLA ("GLA"). 군 6 및 8: 7일 - 44 mg 리툭시맙("aCD20-이중") 및 2개 카피의 5J8 cDNA("5J8-5J8")를 함유하는 단일 pDNA 44 mg, 14일 - 치료 없음. 군 7: 7일 - 44 mg 리툭시맙("aCD20-이중") 및 항-IL5 cDNA의 2개 카피("aIL5-aIL5")를 포함하는 단일 pDNA 44 mg, 14일 - 치료 없음. 항-CoV2 mAb 단백질의 혈청 수준은 초기 처리 24시간 후 ELISA로 측정하고 그 후 매주 측정했다. 표시된 시점은 모두 pDNA의 초기 주입과 관련이 있다. 군 평균 +/- SEM 발현 수준이 그래프에 표시된다.
도 5b와 관련하여: 처리군 4(위)에서 처리된 마우스로부터의 혈청은 다음 지시된 바와 같이 pDNA를 함유하는 GCSF + GLA 및 ACE2 + GH로 처리 후에 15일 및 22일에 혈청에서 비-모노클로날 항체 치료 인간 단백질 G-CSF, GLA, GH 및 ACE2의 발현에 대해 ELISA에 의해 측정되었다.
도 5a 및 5b에 제시된 결과는 매주 상이한 DNA mAb 벡터를 연속 주입하면 개별 마우스에서 4개의 상이한 온전한 모노클로날 항체 및 4개의 기타 비-모노클로날 항체 치료 단백질(총 8개의 치료 단백질)의 지속적으로 유의미한 혈청 수준을 생성할 수 있음을 보여준다.
실시예 6
다중-MAb 발현
이 실시예는 마우스에서 단일 처리 후 3가지 상이한 모노클로날 항체 단백질의 생성을 설명한다.
실험 방법: 0일째에, 군당 3마리의 마우스로 이루어진 8개의 군에 지질(2.5 mol% 덱사메타손 팔미테이트를 포함하는 1000 nmol DOTAP SUV 및 5 mol% 덱사메타손 팔미테이트를 포함하는 1000 nmol DMPC(1,2-디미리스토일-SN-글리세로-3-포스포콜린) 중성 지질)의 순차적 IV 주입 2시간 전에 덱사메타손(40 mg/kg)을 IP 주입했고, 지시된 용량으로 다음의 cDNA를 포함하는 다음 pDNA(들)를 투여했다: 군 1: 항-SARS-CoV2 B38 카파 및 항-IL5("mB38-haIL5")를 암호화하는 단일 pDNA 88 mg; 군 2: 항-SARS-CoV2 B38 카파 및 항-IL5("mB38-maIL5")를 암호화하는 단일 pDNA 88 mg; 군 3: 항-SARS-CoV2 B38 람다 및 항-인플루엔자 A 5J8("mB38-h5J8")을 암호화하는 단일 pDNA 88 mg; 군 4: 항-SARS-CoV2 B38 람다 및 항-인플루엔자 A 5J8("mB38-m5J8")을 암호화하는 단일 pDNA 88 mg; 군 5: 항-IL5의 2개 카피("aIL5-aIL5")를 암호화하는 단일 pDNA 44 mg 및 항-SARS-CoV2("H4")를 암호화하는 단일 pDNA 44 mg; 군 6: 항-IL5의 3개 카피("aIL5-aIL5-aIL5")를 암호화하는 단일 pDNA 44 mg 및 항-SARS-CoV2("H4")를 암호화하는 단일 pDNA 44 mg; 군 7: 항-인플루엔자 A 5J8 및 항-IL5("5J8-aILH-aILL")를 암호화하는 단일 pDNA 88 mg; 군 8: 항-인플루엔자 A 5J8 및 항-IL5("5J8-aIL5")를 암호화하는 단일 pDNA 88 mg. 발현된 mAb 단백질의 혈청 수준은 초기 치료 후 1일, 14일 및 22일에 ELISA에 의해 측정되었다. 군 평균 +/- SEM 발현 수준은 도 6에 표시되어 있다.
도 6에 표시된 이러한 결과는 단일 pDNA의 형태 또는 여러 pDNA로 구성된 DNA-암호화된 mAb 벡터의 1회 용량(예를 들어, 양이온 및 중성 지질 사용)이 마우스에서 두 개의 개별 mAb의 지속적인 발현을 생성할 수 있고 pDNA 또는 pDNA의 구조와 구성이 mAb 발현 수준에 기여할 수 있음을 보여준다.
실시예 7
항-Sars-CoV2 단백질 발현
이 실시예는 마우스에서 단일 처리 후 개별적으로 및 조합하여 여러 가지 다른 항-SARS CoV2 치료 단백질의 생산을 설명한다.
실험 방법: 0일째에, 군당 3마리의 마우스로 이루어진 8개의 군에 지질(2.5 mol% 덱사메타손 팔미테이트를 포함하는 1000 nmol DOTAP SUV 및 5 mol% 덱사메타손 팔미테이트를 포함하는 1000 nmol DMPC(1,2-디미리스토일-SN-글리세로-3-포스포콜린) 중성 지질)의 순차적 IV 주입 2시간 전에 덱사메타손(40 mg/kg)을 IP 주입했고, 다음 cDNA를 암호화하는 단일 pDNA 88 mg을 주사했다: 군 1: 가용성 인간 ACE2("hACE2-BV3"), 군 2: 가용성 인간 ACE2의 2개 카피("hACE2-hACE2"), 군 3: 항-SARS-CoV2 mAb B38 카파("B38Kp"), 군 4: 항-SARS-CoV2 mAb H4의 2개 카피("H4-H4"), 군 5: 항-SARS-CoV2 mAb B38 카파 및 가용성 인간 ACE2("B38Kp-hACE2"), 군 6: 가용성 인간 ACE2 및 항-SARS-CoV2 mAb B38 카파("hACE2-B38Kp"), 군 7: 항-SARS-CoV2 mAb H4 및 가용성 인간 ACE2("H4-hACE2"), 군 8: 가용성 인간 ACE2 및 항-SARS-CoV2 mAb H4("hACE2-H4"). 항-SARS-CoV2 mAb의 혈청 발현 수준은 재조합 정제 H4 또는 B38 카파를 표준으로 사용하는 항-RBD ELISA 또는 비-항원-특이적 인간 IgG 또는 인간 카파 경쇄 ELISA로 측정했다. 가용성 인간 ACE2의 혈청 발현 수준은 상업적 ELISA에 의해 결정되었다. 군 평균 +/- SEM 발현 수준은 도 7에 표시되어 있다.
도 7의 결과는 항-SARS-CoV2 치료제(가용성 인간 ACE2 단백질 및/또는 SARS-CoV2 스파이크 단백질 단독 또는 조합에 반응하는 항-SARS-CoV-2 mAb)가 단일 pDNA 벡터로 단일 처리 후 동물에서 생산될 수 있음을 보여준다.
실시예 8
항-Sars-CoV2 단백질 발현
이 실시예는 마우스에서 리포좀 및 덱사메타손 처리 후 개별적으로 및 조합하여 여러 가지 다른 항-SARS CoV2 치료 단백질의 생산을 설명한다.
실험 방법: 0일째에, 군당 3마리의 마우스로 이루어진 4개의 군에 지질(2.5 mol% 덱사메타손 팔미테이트를 포함하는 1000 nmol DOTAP SUV 및 5 mol% 덱사메타손 팔미테이트를 포함하는 1000 nmol DMPC(1,2-디미리스토일-SN-글리세로-3-포스포콜린) 중성 지질)의 순차적 IV 주입 2시간 전에 덱사메타손(40 mg/kg)을 IP 주입했고, 다음 cDNA를 암호화하는 단일 pDNA 88 mg을 주사했다: 군 1: 가용성 인간 ACE2-Fc 융합("shACE2-Fc"), 군 2: 가용성 인간 ACE2-Fc 융합 LALA 변이체("shACE2-Fc-LALA"), 군 3: 항-SARS-CoV2 mAb 4A8 및 가용성 인간 ACE2-Fc 융합("4A8-shACE2-Fc"), 군 4: 가용성 인간 ACE2-Fc 융합의 2개 카피("shACE2-shACE2").
도 8a에서 가용성 인간 ACE2-함유 단백질의 혈청 발현 수준은 처리 후 1일과 9일에 SARS-CoV2 RBD-기반 ELISA에 의해 결정되었다. 군 평균 +/- SEM 발현 수준이 그래프에 표시된다.
도 8b에서, 가용성 인간 ACE2-Fc 융합체의 혈청 발현 수준은 처리 후 1일 및 9일에 Fc-특이적 ELISA에 의해 군 1 내지 3에서 결정되었다. 군 평균 +/- SEM 발현 수준이 그래프에 표시된다.
도 8a 및 8b에 표시된 결과는 항-SARS-CoV2 치료제(가용성 인간 ACE2 융합 단백질 단독 또는 SARS-CoV2 스파이크 단백질에 반응하는 4A8 mAb와 조합하여)는 pDNA 벡터로 리포좀 및 덱사메타손 처리 후 생체 내에서 발현될 수 있음를 입증한다.
실시예 9
ACE2 단백질 발현
이 실시예는 마우스에서 인간 ACE2 및 변형된 변이체의 생성을 기술한다.
실험 방법: 0일째에, 군당 3마리의 마우스로 이루어진 12개의 군에 지질(2.5 mol% 덱사메타손 팔미테이트를 포함하는 1000 nmol DOTAP SUV 및 5 mol% 덱사메타손 팔미테이트를 포함하는 1000 nmol DMPC(1,2-디미리스토일-SN-글리세로-3-포스포콜린) 중성 지질)의 순차적 IV 주입 2시간 전에 덱사메타손(40 mg/kg)을 IP 주입했고, 표시된 대로 인간 ACE2 cDNA(군 1) 또는 ACE2의 변형된 버전, 군 2-12를 암호화하는 단일 pDNA 88 mg을 주입했다. 하루 후, 포획을 위한 재조합 RBD 단백질 및 검출을 위한 항-Fc 시약 또는 항-ACE2 시약을 사용하여 ELISA에 의해 ACE2의 혈청 발현을 측정하였다. 군 평균 +/- SEM 발현 수준은 결과를 보여주는 도 9에 표시된다.
실시예 10
반감기 연장 펩티드에 융합된 인간 성장 호르몬의 발현
본 실시예는 반감기 연장 펩티드에 융합된 인간 성장 호르몬(hGH)의 생체내 발현을 설명한다.
방법: CD-1 마우스 4마리(빨간색) 또는 3마리(기타 군)에 각각 40 mg/kg 수용성 덱사메타손 IP를 주입했다. 2시간 후, 마우스에 리포좀을 먼저 IV 주사하고 약 2분 후에 인간 GH(hGH)를 암호화하는 75 ug 플라스미드 DNA를 주사했다. 모든 리포좀 혼합물은 2.5% 덱사메타손 21-팔미테이트를 포함하는 1000 nmol DOTAP SUV 및 5% 덱사메타손 21-팔미테이트를 포함하는 1000 nmol DMPC를 함유하였다. 마우스는 주사 후 24시간 후에 채혈되었고, 그 후 매주 또는 몇 주마다 혈청을 얻었다. hGH의 혈청 수준은 ELISA에 의해 평가되었다. 주사 후 127일에 마우스 IGF-1 및 hGH의 혈청 수준을 각각의 ELISA에 의해 공동으로 평가하였다.
결과는 도 45에 제시되어 있다. 도 45a는 이 절차가 Fc, 혈청 알부민 또는 Xten을 포함하는 단백질 반감기 연장 DNA 서열에 융합된 야생형 hGH cDNA의 발현을 구동하고, 시간 경과에 따라 단백질 반감기 연장 DNA 서열이 결여된 hGH DNA 벡터에 의해 생성된 hGH 혈청 수준과 비교할 때 면역적격 마우스에서 hGH 혈청 수준을 상당히 증가시킬 수 있음을 보여준다. 도 45b는 생성된 cDNA-암호화된 hGH 단백질이 hGH-조절된 내인성 마우스, IGF-1 단백질의 수준을 적절하게 증가시키기 때문에 완전히 생체활성임을 보여준다. 도 45c는 이 절차에서 DNA 벡터의 1회 주사가 야생형 hGH cDNA를 구동하지만 임의의 단백질 반감기 연장 DNA 서열이 결여되어 면역적격 마우스에서 치료 hGH 혈청 수준의 지속적인 생성을 생성할 수 있음을 보여준다. 이것은 hGH 단백질의 혈청 반감기가 20분 미만이라는 사실에도 불구하고 그렇다.
실시예 11
반감기 연장 펩티드에 융합된 인간 성장 호르몬의 발현
본 실시예는 반감기 연장 펩티드에 융합된 인간 성장 호르몬(hGH)의 생체내 발현을 설명한다.
방법: CD-1 마우스 4마리 군에 각각 40 mg/kg 수용성 덱사메타손 IP를 주입했다. 2시간 후, 마우스에 리포좀을 먼저 IV 주사하고 약 2분 후에 인간 GH(hGH)를 암호화하는 75 ug 플라스미드 DNA를 주입했다. 모든 리포좀 혼합물은 2.5% 덱사메타손 21-팔미테이트를 포함하는 1000 nmol DOTAP SUV 및 5% 덱사메타손 21-팔미테이트를 포함하는 1000 nmol DMPC를 함유하였다. 마우스는 주사 후 24시간 후에, 그 후 혈청을 분리하기 위해 매 7-21일에 채혈되었다. hGH의 혈청 수준은 ELISA에 의해 평가되었다.
도 46에 제시된 결과는 이 절차가 Fc, 혈청 알부민 또는 Xten을 포함하는 단백질 반감기 연장 DNA 서열에 융합된 야생형 hGH cDNA의 발현을 구동하고, 시간 경과에 따라 단백질 반감기 연장 DNA 서열이 결여된 hGH DNA 벡터에 의해 생성된 hGH 혈청 수준과 비교할 때 면역적격 마우스에서 hGH 혈청 수준을 상당히 증가시킬 수 있음을 보여준다.
실시예 12
플라스미드 재주입에 의한 인간 성장 호르몬의 발현
본 실시예는 플라스미드의 재주입으로 인간 성장 호르몬(hGH)의 생체내 발현을 설명한다.
방법: CD-1 마우스 4마리 군에 각각 40 mg/kg 수용성 덱사메타손 IP를 주입했다. 2시간 후, 마우스에 리포좀을 먼저 IV 주사하고 약 2분 후에 인간 GH(hGH)를 암호화하는 75 ug 플라스미드 DNA를 주사했다. 모든 리포좀 혼합물은 2.5% 덱사메타손 21-팔미테이트를 포함하는 1000 nmol DOTAP SUV 및 5% 덱사메타손 21-팔미테이트를 포함하는 1000 nmol DMPC를 함유하였다. 발현을 평가하기 위해 마우스를 매주 채혈하였다. 사전 재주입을 위해 초기 주입 후 43일 동안의 발현을 나타내었다. 49일에, 마우스는 초기 주입과 동일한 처리를 받았다. 마우스는 주입 후 24시간 후에, 그 후 혈청을 분리하기 위해 매 7-21일에 채혈되었다. hGH의 혈청 수준은 ELISA에 의해 평가되었다.
이들 결과는 도 47에 나타나 있으며, 이 절차를 사용하여 야생형 hGH cDNA를 면역적격인 마우스로 완전히 구동하는 DNA 벡터의 1회 재주입이 초기 hGH DNA 벡터 주입에 의해 생성된 혈청 hGH 수준을 상당히 그리고 지속적으로 추가로 증가시킬 수 있음을 입증한다.
실시예 13
반감기 연장 펩티드에 융합된 인간 성장 호르몬의 발현
본 실시예는 반감기 연장 펩티드에 융합된 인간 성장 호르몬(hGH)의 생체내 발현을 설명한다.
방법: 5마리의 CD-1 마우스 군을 사용하였다. 마우스에 40 mg/kg 수용성 덱사메타손 IP를 주입했다. 2시간 후, 마우스에 리포좀을 먼저 IV 주입하고 약 2분 후에 인간 GH를 암호화하는 75 ug 플라스미드 DNA를 주입했다. 모든 리포좀 혼합물은 2.5% 덱사메타손 21-팔미테이트를 포함하는 1000 nmol DOTAP SUV 및 5% 덱사메타손 21-팔미테이트를 포함하는 1000 nmol DMPC를 함유하였다. 마우스는 주입 후 24시간 후에, 그 후 혈청을 분리하기 위해 매 7-28일에 채혈되었고 혈청 수준은 ELISA에 의해 평가되었다.
결과는 도 48에 제시되어 있다. 이러한 결과는 Fc 단백질 반감기 연장 DNA 서열에 융합된 야생형 hGH cDNA를 구동하는 DNA 벡터를 사용한 이 절차가 면역적격 마우스에 1회 주입 후 적어도 다음 225일 동안(정상 마우스 수명의 >30%) 1 내지 10 ng/ml hGH 치료 범위 내에서 혈청 hGH 수준을 생성할 수 있음을 입증한다.
실시예 14
반감기 연장 펩티드에 융합된 인간 성장 호르몬의 발현
본 실시예는 반감기 연장 펩티드에 융합된 인간 성장 호르몬(hGH)의 생체내 발현을 설명한다.
방법: 3마리의 CD-1 마우스 군에 40 mg/kg 수용성 덱사메타손 IP를 주입했다. 2시간 후, 마우스에 리포좀을 먼저 IV 주입하고 약 2분 후에 인간 GH를 암호화하는 75 ug 플라스미드 DNA를 주입했다. 모든 리포좀 혼합물은 2.5% 덱사메타손 21-팔미테이트를 포함하는 1000 nmol DOTAP SUV 및 5% 덱사메타손 21-팔미테이트를 포함하는 1000 nmol DMPC를 함유하였다. 마우스는 주입 후 24시간 후에, 그 후 혈청을 분리하기 위해 매 7-21일에 채혈되었고 혈청 수준은 ELISA에 의해 평가되었다.
결과는 도 49에 제시되어 있다. 이러한 결과는 Fc 단백질 반감기 연장 DNA 서열에 융합된 야생형 hGH cDNA를 구동하는 DNA 벡터를 사용하여 cDNA-암호화된 hGH 단백질이 적절하게 hGH-조절된 내인성 마우스, IGF-1 단백질 수준을 증가시키기 때문에, 마우스에서 완전한 생체활성 hGH 단백질을 생산함을 입증한다.
실시예 15
반감기 연장 펩티드에 융합된 인간 성장 호르몬의 발현
본 실시예는 반감기 연장 펩티드에 융합된 인간 성장 호르몬(hGH)의 생체내 발현을 설명한다.
방법: 3마리의 CD-1 마우스 군에 40 mg/kg 수용성 덱사메타손 IP를 주입했다. 2시간 후, 마우스에 리포좀을 먼저 IV 주입하고 약 2분 후에 인간 GH를 암호화하는 75 ug 플라스미드 DNA를 주입했다. 모든 리포좀 혼합물은 2.5% 덱사메타손 21-팔미테이트를 포함하는 1000 nmol DOTAP SUV 및 5% 덱사메타손 21-팔미테이트를 포함하는 1000 nmol DMPC를 함유하였다. 마우스는 주입 후 혈청을 분리하기 위해 1일 및 15일에 채혈되었고 혈청 수준은 ELISA에 의해 평가되었다.
도 50은 결과를 보여준다. 도 50a는 CTP를 포함하는 Fc 단백질 반감기 연장 DNA 서열에 융합된 야생형 hGH cDNA를 구동하는 DNA 벡터의 Fc 영역의 선택적 부위-지정 돌연변이유발이 면역적격 마우스에서 생성된 혈청 hGH 수준을 선택적으로 증가시키거나 감소시킬 수 있음을 보여준다. 도 50b는 Fc 단백질 반감기 연장 DNA 서열에 융합된 야생형 hGH cDNA를 구동하는 DNA 벡터의 Fc 영역의 선택적 부위-지정 돌연변이유발이 면역적격 마우스에서 시간 경과에 따라 생성된 혈청 hGH 수준을 선택적으로 증가시킬 수 있음을 보여준다.
실시예 16
면역-조절제
이 실시예는 다양한 면역조절제의 테스트를 설명한다.
파트 1
방법: 3마리의 CD-1 마우스 군에 도 51에 표시된 대로 덱사메타손 21-팔미테이트 또는 콜레스테롤 팔미테이트 몰 백분율을 포함하거나 포함하지 않는 각각 900 nmol DOTAP SUV를 주입했다. 리포좀 주입 2분 후, 마우스에 hG-CSF를 암호화하는 70 ug 플라스미드 DNA 주입했다. 다음 날 마우스에서 채혈하고 hG-CSF 단백질의 혈청 수준을 ELISA로 평가했다. ALT 수준은 혈청에서 평가되었다. 결과는 도 51에 나타나 있으며, 이것은 양이온성 리포좀에 최적화된 몰 백분율의 덱사메타손 팔미테이트(DexPalm)를 혼입시키는 것이 유전자 발현을 추가로 증가시키고 독성을 추가로 감소시킬 수 있음을 보여준다.
파트 2
방법: 각각 3마리의 CD-1 마우스 군을 사용하였다. 한 군(+ Dex)은 40 mg/kg 덱사메타손을 IP로 주입했고, 한 군(+ DexP IP)은 2.5몰% 덱사메타손 21-팔미테이트를 함유한 900 nmol DOTAP 리포좀을 IP로 주입했으며, 한 군(프로타민)은 프로타민 설페이트 5 mg/kg을 IP로 주입했다. 2시간 후, 도 52에 나타낸 바와 같이 몰 백분율로 덱사메타손 21-팔미테이트 또는 콜레스테릴 팔미테이트를 포함하거나 포함하지 않는 900 nmol DOTAP SUV를 마우스에 먼저 주입하였다. 리포좀 주입 2분 후, hG-CSF를 암호화하는 70 ug 플라스미드 DNA를 마우스에 주입하였다. 다음 날 마우스에서 채혈하고 hG-CSF 단백질의 혈청 수준을 ELISA로 평가했다. ALT 수준은 혈청에서 평가되었다. 결과는 도 52에 제시되어 있으며, 이것은 양이온성 리포좀에 최적화된 몰 백분율의 덱사메타손 팔미테이트를 혼입시키는 것이 유전자 발현을 추가로 증가시키고 독성을 추가로 감소시킬 수 있음을 보여준다.
파트 3
방법: 각각 3마리의 CD-1 마우스 군을 사용하였다. 한 군은 각각 2.5% 덱사메타손 21-팔미테이트를 포함하는 900 nmol DOTAP 리포좀을 IV 주입 전 5분, IV 주입 후 5분 또는 30분 전에 IP 주사했다. 한 군은 한 군(프로타민)은 IV 주입 5분 전에 프로타민 설페이트 5 mg/kg을 IP 주입했다. IV 주입를 위해, 리포좀에 2.5% 덱사메타손 21-팔미테이트가 포함된 900 nmol DOTAP SUV를 마우스에 먼저 주입했다. 리포좀 주입 2분 후, 마우스에 hG-CSF를 암호화하는 70 ug 플라스미드 DNA를 주입하였다. 다음 날 마우스에서 채혈하고 hG-CSF 단백질의 혈청 수준을 ELISA로 평가했다. ALT 수준은 혈청에서 평가되었다. 도 53은 양이온성 리포좀을 주입하기 전에 리포좀에 덱사메타손 팔미테이트의 최적화된 몰 백분율을 사전 주입하면 유전자 발현을 추가로 증가시키고 독성을 추가로 감소시킬 수 있음을 보여주는 결과를 보여준다.
파트 4
방법: 3마리의 CD-1 마우스 군에 도 54에 나타낸 바와 같이 리포좀에서 몰 백분율로 다수의 상이한 내인성 항염증성 지질(AIL) 중 하나를 포함하거나 포함하지 않는 900 nmol DOTAP SUV를 각각 주입했다. 리포좀 주입 2분 후, hG-CSF를 암호화하는 70 ug 플라스미드 DNA를 마우스에 주입하였다. 다음 날 마우스에서 채혈하고 hG-CSF 단백질의 혈청 수준을 ELISA로 평가했다. ALT 수준은 혈청에서 평가되었다. 결과는 도 54에 나타나 있으며, 이는 양이온성 리포좀에 혼입된 일부 AIL을 주입하면 유전자 발현을 추가로 증가시키고 독성(ALT 수준)을 추가로 감소시킬 수 있음을 보여준다. 대조적으로, 양이온성 리포좀에 혼입된 다른 AIL의 선택된 몰 백분율을 주입하면 ALT가 상당히 증가할 수 있다.
파트 5
방법: 3마리의 CD-1 마우스 군에 도 55에 나타낸 바와 같이 리포좀에서 몰 백분율로 다수의 상이한 내인성 항염증성 지질(AIL) 중 하나를 포함하거나 포함하지 않는 900 nmol DOTAP SUV를 각각 주입했다. 리포좀 주입 2분 후, hG-CSF를 암호화하는 70 ug 플라스미드 DNA를 마우스에 주입하였다. 다음 날 마우스에서 채혈하고 hG-CSF 단백질의 혈청 수준을 ELISA로 평가했다. ALT 수준은 혈청에서 평가되었다. 결과는 도 55에 나타나 있으며, 이는 양이온성 리포좀에 통합된 특정 AIL을 주입하면 유전자 발현을 추가로 증가시키고 독성(ALT 수준)을 추가로 감소시킬 수 있음을 보여준다. 대조적으로, 양이온성 리포좀에 혼입된 다른 AIL의 선택된 몰 백분율을 주입하면 ALT가 상당히 증가할 수 있다.
파트 6
방법: 각각 3마리의 CD-1 마우스 군을 사용했다. 한 군(+ Dex)은 40 mg/kg 덱사메타손으로 IP 주입되었다. 2시간 후, 마우스에게 5몰% 덱사메타손 21-팔미테이트가 있거나 없는 900 nmol DOTAP SUV를 주입했다. 리포좀 주입 2분 후, hG-CSF를 암호화하는 40 또는 130 ug 플라스미드 DNA를 마우스에 주입하였다. 다음 날 마우스에서 채혈하고 hG-CSF 단백질의 혈청 수준을 ELISA로 평가했다. ALT 수준은 혈청에서 평가되었다. 결과는 도 56에 나타나 있으며, 최적화된 몰 백분율의 덱사메타손 팔미테이트를 양이온성 리포좀에 혼입시키는 것이 그렇지 않으면 비효율적인 hG-CSF-DNA 투여량 이후에 유전자 발현의 피크 수준을 추가로 증가시킬 수 있음을 보여준다.
실시예 17
비강내 투여 및 면역조절
이 실시예는 리포좀의 비강내 투여 후 마우스 폐에서 조혈 세포를 표적화하는 것을 설명한다.
실험 방법: 마우스를 마취시키고 각각 1 mol% 형광 포스파티딜-에탄올아민을 함유하는 지시된 리포좀 제형의 200 nmol을 비강내 경로를 통해 투여하여 리포좀 또는 락티드 링거 대조군의 흡수를 추적하였다. 하루 후, 폐를 수확하고, 단일 세포 현탁액으로 분해하고, 형광 항체로 표면 염색하여 유세포 분석에 의한 분석 전에 마우스 CD45, CD11b 및 F4/80 마커를 검출했다. DOPS = 1,2-디올레오일-sn-글리세로-3-포스포-L-세린, mixPS = 1-스테아로일-2-올레오일-sn-글리세로-3-포스포-L-세린. 결과는 도 57에 나타나 있으며, 이는 비강내로 투여된 리포좀의 지질 조성을 선택적으로 변형함으로써, 이들 리포좀이 상이한 정도로 폐내 단핵구 및 대식세포에 선택적으로 표적화할 수 있고, 따라서 폐를 선택적으로 면역-조절할 수 있음을 보여준다.
실시예 18
차등 T 세포 활성화
이 실시예는 특정 리포좀 제형의 투여로부터 발생하는 차별적인 T 세포 활성화를 설명한다.
실험 방법: 0일에, 각 군당 3마리의 마우스를 포함하는 6개의 마우스 군에 다음과 같은 처리를 제공했다.
군 1 - 지질(2.5 mol% 덱사메타손 팔미테이트를 포함하는 1000 nmol DOTAP SUV 및 5 mol% 덱사메타손 팔미테이트 포함하는 1000 nmol DMPC(1,2-디미리스토일-SN-글리세로-3-포스포콜린) 중성 지질)의 순차적 IV 주입 2시간 전 덱사메타손(40 mg/kg)의 IP 주입 후, 항-SARS CoV2 H4 카파 mAb, 항-CD20, 항-인플루엔자 A 5J8 및 항-인간 IL-5를 암호화하는 단일 pDNA를 투여했다.
군 2 - 지질(2.5 mol% 덱사메타손 팔미테이트를 포함하는 1000 nmol DOTAP SUV 및 5 mol% 덱사메타손 팔미테이트 포함하는 1000 nmol DMPC(1,2-디미리스토일-SN-글리세로-3-포스포콜린) 중성 지질)의 순차적 IV 주입 후, 항-SARS CoV2 H4 카파 mAb, 항-CD20, 항-인플루엔자 A 5J8 및 항-인간 IL-5를 암호화하는 단일 pDNA 를 투여했다.
군 3 - 지질(5 mol% 덱사메타손 팔미테이트를 포함하는 1000 nmol DOTAP SUV 및 1000 nmol DMPC(1,2-디미리스토일-SN-글리세로-3-포스포콜린 중성 지질)의 순차적 IV 주입 후, 항-SARS CoV2 H4 카파 mAb, 항-CD20, 항-인플루엔자 A 5J8 및 항-인간 IL-5를 암호화하는 단일 pDNA 를 투여했다.
군 4 - 지질(2.5 mol% 덱사메타손 팔미테이트를 포함하는 1000 nmol DOTAP SUV 및 1000 nmol DMPC(1,2-디미리스토일-SN-글리세로-3-포스포콜린) 중성 지질)의 순차적 IV 주입 후, 항-SARS CoV2 H4 카파 mAb, 항-CD20, 항-인플루엔자 A 5J8 및 항-인간 IL-5를 암호화하는 단일 pDNA 를 투여했다.
군 5 - 지질(2.5 mol% 덱사메타손 팔미테이트를 포함하는 1000 nmol DOTAP SUV 및 5 mol% 덱사메타손 팔미테이트 포함하는 1000 nmol DMPC(1,2-디미리스토일-SN-글리세로-3-포스포콜린) 중성 지질)의 순차적 IV 주입 후, 항-SARS CoV2 H4 카파 mAb, 항-CD20, 항-인플루엔자 A 5J8 및 항-인간 IL-5를 암호화하는 단일 pDNA 를 투여했다.
군 6 - 치료 없음
도 58은 비경구 수용성 예비용량 및/또는 차후 투여된 리포좀에 혼입된 덱사메타손 팔미테이트의 몰 백분율을 선택적으로 변형함으로써 폐 및 혈액 모두에서 T 림프구 활성화 수준이 선택적으로 면역-조절될 수 있다는 결과를 보여준다.
실시예 19
차등 T 세포 활성화
이 실시예는 리포좀 제형의 투여로부터 발생하는 차별적인 T 세포 활성화를 설명한다.
실험 방법: 0일에, 각 군당 3마리의 마우스를 포함하는 8개의 마우스 군에 다음과 같은 치료를 제공했다.
군 1 - 치료 없음
군 2 - 지질(2.5 mol% 덱사메타손 팔미테이트를 포함하는 1000 nmol DOTAP SUV 및 5 mol% 덱사메타손 팔미테이트 포함하는 1000 nmol DMPC(1,2-디미리스토일-SN-글리세로-3-포스포콜린) 중성 지질)의 순차적 IV 주입 2시간 전 덱사메타손(40 mg/kg)의 IP 주사 후, 인간 PECAM-1을 암호화하는 단일 pDNA를 투여했다.
군 3 - 지질(2.5 mol% 덱사메타손 팔미테이트를 포함하는 1000 nmol DOTAP:콜레스테롤(85:15) SUV 및 5 mol% 덱사메타손 팔미테이트 포함하는 1000 nmol DMPC(1,2-디미리스토일-SN-글리세로-3-포스포콜린) 중성 지질)의 순차적 IV 주입 2시간 전 덱사메타손(40 mg/kg)의 IP 주사 후, 인간 PECAM-1을 암호화하는 단일 pDNA를 투여했다.
군 4 - 지질(2.5 mol% 덱사메타손 팔미테이트를 포함하는 1000 nmol DOTAP:DODAP(1:1) SUV 및 5 mol% 덱사메타손 팔미테이트 포함하는 1000 nmol DMPC(1,2-디미리스토일-SN-글리세로-3-포스포콜린) 중성 지질)의 순차적 IV 주입 2시간 전 덱사메타손(40 mg/kg)의 IP 주사 후, 인간 PECAM-1을 암호화하는 단일 pDNA.
군 5 - 지질(2.5 mol% 덱사메타손 팔미테이트를 포함하는 1000 nmol DOTAP SUV 및 5 mol% 덱사메타손 팔미테이트 포함하는 1000 nmol DMPC(1,2-디미리스토일-SN-글리세로-3-포스포콜린) 중성 지질:콜레스테롤(1:1))의 순차적 IV 주입 2시간 전 덱사메타손(40 mg/kg)의 IP 주사 후, 인간 PECAM-1을 암호화하는 단일 pDNA를 투여했다.
군 6 - 지질(2.5 mol% 덱사메타손 팔미테이트를 포함하는 1000 nmol DOTAP SUV 및 5 mol% 덱사메타손 팔미테이트 포함하는 1000nmol DMPC(1,2-디미리스토일-SN-글리세로-3-포스포콜린) 중성 지질:콜레스테롤(1:1))의 순차적 IV 주입 2시간 전 덱사메타손(40 mg/kg)의 2회의 IP 주사 후, 인간 PECAM-1을 암호화하는 단일 pDNA가 뒤따랐다.
군 7 - 포스파티딜세린:콜레스테롤 2:1 MLV 24시간 중 2.5 mol% 덱사메타손 팔미테이트의 2회 IP 주입 및 지질(2.5 mol% 덱사메타손 팔미테이트를 포함하는 1000 nmol DOTAP SUV 및 5 mol% 덱사메타손 팔미테이트 포함하는 1000nmol DMPC(1,2-디미리스토일-SN-글리세로-3-포스포콜린) 중성 지질)의 순차적 IV 주입 2시간 전, 인간 PECAM-1을 암호화하는 단일 pDNA가 뒤따랐다.
군 8 - DOTAP:콜레스테롤 2:1 MLV 24시간 중 2.5 mol% 덱사메타손 팔미테이트의 2회 IP 주사 및 지질(1000 nmol DOTAP SUV 및 5 mol% 덱사메타손 팔미테이트 포함하는 1000nmol DMPC(1,2-디미리스토일-SN-글리세로-3-포스포콜린) 중성 지질)의 순차적 IV 주입 2시간 전, 인간 PECAM-1을 암호화하는 단일 pDNA가 뒤따랐다.
하루 후, 폐 및 말초 혈액을 수확하고, 필요한 경우 단일 세포 현탁액으로 분해하고, 유동 세포측정법으로 분석하기 전에 마우스 CD4, CD8 알파, CD44, CD69 및 인간 PECAM-1 마커를 검출하기 위해 형광 항체로 표면을 염색했다.
도 59는 비경구 수용성 사전투여 및/또는 후속 투여된 리포좀에 혼입된 덱사메타손 팔미테이트의 몰 백분율을 선택적으로 변형함으로써 폐 및 혈액 모두에서 T 림프구 활성화 수준이 선택적으로 면역 조절됨을 보여준다.
실시예 20
항-TNFα 및 헤파리노이드 제제
이 실시예는 생체내 발현 방법에서 발현을 증가시키기 위한 항-TNFα 모노클로날 항체 및 헤파리노이드 제제의 사용을 기술한다.
파트 1 - 항-TNFα 모노클로날 항체
방법: 3마리의 마우스 군을 사용하였다. 한 군은 IV 주입 2시간 전에 마우스 IP 당 각각 100 ug의 항-TNFα 모노클로날 항체를 제공받았다. 이어서, 마우스에 900 nmol DOTAP SUV를 IV 주입하고, 2분 후에 hG-CSF를 암호화하는 70 ug 또는 130 ug 플라스미드 DNA를 주입하였다. 주입 후 24시간에 마우스를 채혈하고, ELISA에 의해 혈청에서 hG-CSF 발현을 평가하였다. 혈청 ALT/AST 수치를 측정하였다.
결과는 도 60에 나타나 있으며, 이는 항염증제, 여기서는 항-TNF 모노클로날 항체의 사전 투여가 유전자 발현을 추가로 증가시키면서 독성을 추가로 감소시킬 수 있음을 보여준다.
파트 2 - NSH
방법: 3마리의 마우스 군을 사용하였다. 대조군을 제외하고 마우스에게 NSH(N-아세틸-데-O-설페이트된 헤파린) IP를 지질 및 DNA 주입 2시간 전 또는 2시간 후에 마우스당 0.25 또는 1 mg 제공했다. 이어서 마우스에 900 nmol DOTAP SUV를 IV 주입한 후, 2분 후에 hG-CSF를 암호화하는 70 ug 플라스미드 DNA를 주입하였다. 주입 후 24시간에 마우스를 채혈하고, ELISA에 의해 혈청에서 hG-CSF 발현을 평가하였다. 혈청 ALT/AST 수치를 측정하였다.
결과는 도 61에 나와 있으며 NSH의 사전 또는 사후 투여가 독성을 감소시킬 수 있음을 보여준다.
파트 3 - NSH
방법: 3마리의 마우스 군을 사용하였다. 헤파리노이드-처리된 마우스에게 NSH(N-아세틸-데-O-설페이트된 헤파린) IP를 지질 및 DNA 주입 2시간 전 또는 2시간 후에 마우스당 0.25 또는 1 mg 제공했다. 이어서 마우스에 900 nmol DOTAP SUV를 IV 주입한 후, 2분 후에 hG-CSF를 암호화하는 70 ug 플라스미드 DNA를 주입하였다. 주입 후 24시간에 마우스를 채혈하고, ELISA에 의해 혈청에서 hG-CSF 발현을 평가하였다. 토코페롤-처리된 마우스는 알파-토코페롤을 함유하는 900 nmol DOTAP SUV를 제공한 후, hG-CSF를 암호화하는 70 ug 플라스미드 DNA를 주입하였다. 혈청 ALT/AST 수치를 측정하였다.
결과는 도 62에 나와 있으며 NSH의 사전 또는 사후 투여가 독성을 감소시킬 수 있음을 보여준다.
파트 4 - NSH
방법: 3마리의 마우스 군을 사용하였다. 헤파리노이드-처리된 마우스에게 NSH(N-아세틸-데-O-설페이트된 헤파린) IP를 지질 및 DNA 주입 2시간 전에 제공했다. 이어서 마우스에 900 nmol DOTAP SUV를 IV 주입한 후, 2분 후에 hG-CSF를 암호화하는 70 ug 플라스미드 DNA를 주사하였다. 주사 후 24시간에 마우스를 채혈하고, ELISA에 의해 혈청에서 hG-CSF 발현을 평가하였다. 토코페롤 마우스에게 알파-토코페롤을 함유하는 900 nmol DOTAP SUV를 제공한 후, hG-CSF를 암호화하는 70 ug 플라스미드 DNA를 제공했다. 혈청 ALT/AST 수치를 측정하였다.
도 63은 NSH의 사전 투여가 독성을 감소시키면서 유전자 발현을 추가로 증가시킬 수 있음을 보여주는 결과를 보여준다.
실시예 21
리포좀 투여 후 면역조절
이 실시예는 덱사메타손 및/또는 덱사메타손 팔미테이트를 함유하는 다양한 리포좀 제형의 투여 후 마우스에서 림프구 및 단핵구 세포 집단의 면역조절을 설명한다.
실험 방법: 2-3마리의 CD-1 마우스 군을 사용하였다. 0일에, 8개 군의 마우스에게 다음과 같은 처리를 제공했다.
군 1 - 수용성 덱사메타손(40 mg/kg)만 IP 주사.
군 2 - 지질(2.5 mol% 덱사메타손 팔미테이트를 포함하는 1000 nmol DOTAP SUV 및 5 mol% 덱사메타손 팔미테이트 포함하는 1000 nmol DMPC(1,2-디미리스토일-SN-글리세로-3-포스포콜린 중성 지질))의 순차적 IV 주입 2시간 전 덱사메타손(40 mg/kg)의 IP 주입.
군 3 - 지질(2.5 mol% 덱사메타손 팔미테이트를 포함하는 1000 nmol DOTAP SUV 및 5 mol% 덱사메타손 팔미테이트를 포함하는 1000 nmol DMPC(1,2-디미리스토일-SN-글리세로-3-포스포콜린 중성 지질))의 IV 주입.
군 4 - 지질(2.5 mol% 덱사메타손 팔미테이트를 포함하는 1000 nmol DOTAP SUV 및 5 mol% 덱사메타손 팔미테이트를 포함하는 1000 nmol DMPC(1,2-디미리스토일-SN-글리세로-3-포스포콜린 중성 지질) MLV의 IV 주입 2시간 전에 5 mol% 덱사메타손 팔미테이트를 포함하는 1000 nmol DMPC(1,2-디미리스토일-SN-글리세로-3-포스포콜린 중성 지질) MLV의 IV 주입.
군 5 - 지질(2.5 mol% 덱사메타손 팔미테이트를 포함하는 1000 nmol DOTAP SUV 및 5 mol% 덱사메타손 팔미테이트를 포함하는 1000 nmol DMPC(1,2-디미리스토일-SN-글리세로-3-포스포콜린 중성 지질) MLV의 IV 주입 2시간 전에 5 mol% 덱사메타손 팔미테이트를 포함하는 1000 nmol DMPC(1,2-디미리스토일-SN-글리세로-3-포스포콜린 중성 지질) SUV의 IP 주입.
군 6 - 지질(2.5 mol% 덱사메타손 팔미테이트를 포함하는 1000 nmol DOTAP SUV) 및 MTAS-NLS-SPD 펩티드를 함유하는 5 mol% 덱사메타손 팔미테이트를 포함하는 1000 nmol DMPC(1,2-디미리스토일-SN-글리세로-3-포스포콜린 중성 지질) MLV의 IV 주입 2시간 전에 5 mol% 덱사메타손 팔미테이트를 포함하는 1000 nmol DMPC(1,2-디미리스토일-SN-글리세로-3-포스포콜린 중성 지질))의 IP 주입.
군 7 - 지질(2.5 mol% 덱사메타손 팔미테이트를 포함하는 1000 nmol DOTAP SUV) 및 MTAS-NLS-SPD 펩티드를 함유하는 5 mol% 덱사메타손 팔미테이트를 포함하는 1000 nmol DMPC(1,2-디미리스토일-SN-글리세로-3-포스포콜린 중성 지질) MLV의 IV 주입 2시간 전에 5 mol% 덱사메타손 팔미테이트를 포함하는 1000 nmol DMPC(1,2-디미리스토일-SN-글리세로-3-포스포콜린 중성 지질))의 IP 주입.
군 8 - 치료 없음.
리포좀 처리 24시간 후, 말초 혈액을 마이크로테이너 튜브를 포함하는 EDTA에서 채취하고 CBC 장치로 분석했다. 군 평균값 +/- SEM이 표시된다. 도 64는 덱사메타손 팔미테이트를 함유하는 리포좀의 다양한 제형의 투여가 덱사메타손 단독의 전신 투여와 비교하여 혈중 림프구 수를 감소시킨다는 것을 보여준다. 도 65는 덱사메타손 팔미테이트를 함유하는 리포좀의 다양한 제형의 투여가 덱사메타손 단독의 전신 투여와 비교하여 혈중 단핵구 수를 감소시킨다는 것을 보여준다.
실시예 22
단일 HEDGES DNA 벡터 투여 후 단일 항-SARS-CoV2 mAb의 지속적인 완전 SARS-CoV-2 중화 수준의 생산
이 실시예에서는 마우스에서 단일 SARS-CoV-2 항체의 발현이 다음 주입 프로토콜을 사용하여 완전히 중화되는 수준의 mAb를 생성하는 것을 설명한다. 마우스에서 개별적으로 발현된 5가지 다른 SARS-CoV-2 항체는 C135, C215, COV2-2355, CV07-209 및 C121이었다(서열 정보는 표 7 참조). 0일에, 마우스 군을 각 1100 nmol의 DOTAP/2.5 mol% 덱사메타손 팔미테이트/SUV 및 DMPC/5 mol% 덱사메타손 팔미테이트/ MLV를 구성하는 리포좀으로 i.v. 투여 2시간 전에 40 mg/kg 수용성 덱사메타손 i.p.로 전처리했다. 2분 후, 5개의 SARS-CoV2 특이적 mAb 중 하나에 대한 발현 카세트 1개를 함유하는 약 80 ug의 단일 플라스미드 DNA로 마우스에 i.v.로 투여했다. 처리 후 1, 8, 22, 30, 36, 50, 78, 92, 106 및 120일에 마우스를 채혈하고 혈청 mAb 단백질 수준을 인간 IgG ELISA 검정으로 측정했다. 결과는 도 66에 나와 있다(왼쪽 축, 분홍색 막대 그래프는 각 mAb에 대해 1일부터 120일까지 오름차순으로 표시된 평균 + 또는 - SEM을 나타낸다). SARS-CoV2 스파이크 - 인간 ACE2 단백질 상호작용을 억제하는 혈청을 함유하는 SARS-CoV2-특이적 mAb 함유 혈청의 기능적 생물활성은 상업적으로 이용가능한 시험관내 SARS-CoV2 스파이크/ACE2 차단 검정으로 결정되었다(cPASS, 오른쪽 축, 녹색 점은 평균 + 또는 - SEM은 각 mAb 클론에 대해 1일부터 120일까지 오름차순으로 표시된다, Genscript).
이 실시예는 도 66에 표시된 바와 같이 5개의 상이한 SARS-CoV2-특이적 mAb 중 하나를 각각 암호화하는 상이한 단일 DNA 발현 플라스미드를 한 번 주입하면 투여 후 적어도 120일의 전체 실험 과정 동안 각 SARS-CoV2-특이적 mAb의 완전히 중화 혈청 수준을 생성한다는 것을 보여주며, 이러한 진행 중인 혈청 mAb 수준이 기능적으로 지속적으로 SARS-CoV2 스파이크 - 인간 ACE2 결합을 적어도 120일 동안 차단한다(인간의 20년 이상에 해당). 이 결과는 단일 SARS-CoV2-특이적 mAb를 암호화하는 DNA 주입을 포함하는 이 프로토콜이 항-SARS-CoV2 혈청 수준을 중화하는 지속성(인체 20년 이상 동등)을 생성할 수 있음을 보여준다.
실시예 23
단일 플라스미드에서 2개의 항-SARS-CoV2 mAb 발현
이 실시예는 마우스에서 단일 플라스미드(4개의 상이한 플라스미드)로부터 2개의 SARS-CoV-2 항체 발현이 다음 주입 프로토콜을 사용하여 중화 수준의 mAb를 생성하는 것을 설명한다. 발현된 SARS-CoV-2 항체는 다음과 같다: 제 1 플라스미드(C135 + CV07-209); 제 2 플라스미드(RBD215 LALA + CV07-209); 제 3 플라스미드(C121 + CV07-209); 및 제 4 플라스미드(CV07-209 + Zost-2355)(서열 정보는 표 7 참조). 0일에 1100 nmol의 각각의 DOTAP/2.5 mol% 덱사메타손 팔미테이트/SUV 및 DMPC/5 mol% 덱사메타손 팔미테이트/MLV를 구성하는 리포좀으로 i.v. 투여 2시간 전에, 마우스 군을 40 mg/kg 수용성 덱사메타손 i.p.로 전처리했다. 2분 후, 마우스에 SARS-CoV2-특이적 mAb에 대한 발현 카세트 2개를 함유하는 약 80 ug의 단일 플라스미드 DNA로 i.v. 투여했다. 처리 후 1, 8, 22, 30, 36, 50, 78, 92, 106일, 120 및 134일에 마우스를 채혈하고 혈청 mAb 단백질 수준을 인간 IgG ELISA 검정으로 측정했다. 결과는 도 67에 제시되어 있다(왼쪽 축, 분홍색 막대 그래프는 각 mAb에 대해 1일부터 134일까지 오름차순으로 표시된 평균 + 또는 - SEM을 나타낸다). SARS-CoV2 스파이크 - 인간 ACE2 단백질 상호작용를 억제하는 SARS-CoV2-특이적 mAb 함유 혈청의 기능적 생물활성 능력은 상업적으로 이용가능한 시험관 내 SARS-CoV2 스파이크/ACE2 차단 검정에 의해 결정되었다(cPASS, 오른쪽 축, 녹색 점은 각 mAb 클론, Genscript에 대해 1일부터 134일까지 오름차순으로 표시된 평균 + 또는 - SEM).
이 실시예는 도 67에 표시된 바와 같이 단일 발현 플라스미드를 한 번 주입하면 이 과정 후 적어도 134일의 전체 실험 과정 동안 단일 플라스미드로부터 2개의 SARS-CoV2-특이적 mAb의 발현을 초래한다는 것을 보여주며, 이러한 혈청-발현 mAb 혈청은 기능적으로 SARS-CoV2 스파이크 - 인간 ACE2 상호작용을 적어도 134일 동안 차단할 수 있다.
실시예 24
3가지 접근법에 의한 2개의 항-SARS-CoV2 mAb의 발현
이 실시예는 3가지 다른 접근 방식으로 동시에 2개의 항-SARS-CoV2 mAb 발현을 설명한다: 1) 2개의 독특한 mAb를 코딩하는 단일 발현 플라스미드의 단일 주입; 2) 혼합물로서 2개의 독특한 플라스미드를 동시에 단일 주입(공동-주입); 및 3) 일정 시간, 여기서는 7일으로 분리된 단일 mAb 발현 플라스미드의 2회 주입(reinj). 발현된 다양한 항-SARS-CoV2 mAbs는 도 68에 나와 있다(서열은 표 7 참조).
0일에, 1000 nmol의 각각의 DOTAP/2.5 mol% 덱사메타손 팔미테이트/SUV 및 DMPC/5 mol% 덱사메타손 팔미테이트/MLV를 구성하는 리포좀으로 i.v. 투여 2시간 전에, 마우스 군을 40 mg/kg 수용성 덱사메타손 i.p.로 전처리했다. 2분 후, SARS-CoV2-특이적 mAb에 대한 1개 또는 2개의 발현 카세트를 함유하는 단일 플라스미드 DNA 75 ug 또는 각각 1개 또는 2개의 mAb 클론용 카세트를 함유하는 2개의 플라스미드 각각 38 ug(공동 주입 - "coinj")으로 마우스에게 i.v. 투여하였다. 7일에 이들 마우스 군 중 일부는 0일와 마찬가지로 덱사메타손 재처리, 리포좀 투여 및 플라스미드 DNA의 추가 주입(재주입 - "reinj")를 받았으며, SARS-CoV2-특이적 mAb용 발현 카세트 2개 함유하는 75 ug의 단일 플라스미드 DNA로 유사하게 처리되었다. 1, 8 및 15, 22일에 마우스를 채혈하고 mAb의 혈청 발현을 인간 IgG ELISA 검정으로 분석했다. 결과는 도 68a에 제시되어 있으며, 각각의 일련의 막대 그래프는 1, 8, 15 및 22일에 왼쪽에서 오른쪽 순서로 평균 +/- SEM mAb 발현 또는 억제량을 나타낸다.
도 68b는 SARS-CoV2 스파이크 - 인간 ACE2 단백질 상호작용를 억제하는 SARS-CoV2-특이적 mAb 함유 혈청의 기능적 능력을 상업적으로 이용가능한 시험관내 SARS-CoV2 스파이크/ACE2 차단 검정(cPASS, Genscript)으로 결정한 것을 보여준다. 일련의 막대 그래프는 1, 8, 15 및 22일에 왼쪽에서 오른쪽 순서로 평균 +/- SEM mAb 발현 또는 억제 양을 나타낸다.
이 실시예는 이 프로토콜이 시도한 세 가지 접근 방식으로 동시에 두 개의 항 SARS-CoV2 mAbs를 생성하는 방법을 보여준다(도 68의 결과). 모든 접근법은 SARS-CoV2/ACE2 상호작용의 중화를 허용하는 수준에서 동물의 혈청에서 2개의 mAb의 발현을 성공적으로 허용한다.
실시예 25
3개의 항-SARS-CoV2 mAbs 발현
이 실시예는 플라스미드의 매주 2회 주입을 기반으로 하나 또는 두 개의 플라스미드에서 세 가지 상이한 항-SARS-CoV2 mAb의 발현을 설명한다. 이는 도 69(표 7의 서열)에 나타낸 바와 같이 3개의 상이한 mAbs 켈렉션으로 수행하였다.
0일에, 각각 1000 nmol의 DOTAP/2.5 mol% 덱사메타손 팔미테이트/SUV 및 DMPC/5 mol% 덱사메타손 팔미테이트/MLV를 구성하는 리포좀으로 i.v. 투여 2시간 전에, 마우스 군을 40 mg/kg 수용성 덱사메타손 i.p.로 전처리했다. 2분 후, SARS-CoV2-특이적 mAb에 대한 1개 발현 카세트를 함유하는 단일 플라스미드 DNA 80 ug으로 마우스에게 i.v. 투여하였다. 7일에 이들 마우스 군 중 일부는 0일과 마찬가지로 덱사메타손 전치료, 리포좀 투여 및 플라스미드 DNA의 추가 주입을 받았다. 이들 군은 SARS-CoV2-특이적 mAb에 대한 발현 카세트 2개 함유하는 80 ug의 단일 플라스미드 DNA로 처리되었다.
첫 처리 후 1, 8, 15, 21, 36, 50, 64, 78, 92, 106, 120일에 마우스를 채혈하고 mAb의 혈청 발현을 인간 IgG ELISA 검정으로 분석했다. 결과는 도 69에 제시되어 있으며, 각각의 일련의 막대 그래프는 1, 8, 15, 21, 36, 50, 64, 78, 92, 106, 120일에서 왼쪽에서 오른쪽 순서로 평균 +/- SEM mAb 발현 또는 억제량을 나타낸다. 동시에, SARS-CoV2 스파이크 - 인간 ACE2 단백질 상호작용를 억제하는 SARS-CoV2-특이적 mAb 함유 혈청의 기능적 능력은 시간 경과에 따라 상업적으로 이용가능한 시험관내 SARS-CoV2 스파이크/ACE2 차단 검정(cPASS, Genscript)의해 결정되었다. 이들 억제 결과는 도 69에서 녹색으로 나타내었다. 일련의 막대 그래프는 1, 8, 15, 21, 36, 50, 78, 92, 106, 120일에 평균 +/- SEM mAb 억제(오른쪽 y축)를 나타낸다.
이 실시예는 총 3개의 서로 다른 개별 SARS-CoV2 특이적 mAb를 암호화하는 1개 또는 2개의 DNA 발현 플라스미드를 매주 2회 주사하면 투여 후 적어도 70일 동안 3개의 서로 다른 SARS-CoV2 특이적 mAb의 혈청 수준을 완전히 중화시키는 것을 보여주며, 이러한 진행 중인 혈청 mAbs 수준은 기능적으로 지속적으로 SARS-CoV2 스파이크 - 인간 ACE2를 최소 70일 동안 차단하며, 이는 인간의 경우 10년 이상에 해당한다. 이 결과는 3가지 상이한 SARS-CoV2-특이적 mAb를 암호화하는 주 2회의 헤지 DNA 주입이 항-SARS-CoV2 mAb 혈청 수준을 완전히 중화하는 내구성(인간의 10년 이상 동등)을 생성한다는 것을 나타낸다.
실시예 26
4개의 항-SARS-CoV2 mAbs 발현
이 실시예는 다음 프로토콜을 사용하여 도 70(서열 정보는 표 7 참조)에 표시된 4개의 항-SARS-CoV2 mAb의 발현을 설명한다. 0일에, 각각 1000 nmol의 DOTAP/2.5 mol% 덱사메타손 팔미테이트/SUV 및 DMPC/5 mol% 덱사메타손 팔미테이트/MLV를 구성하는 리포좀으로 i.v. 투여 2시간 전에, 마우스 군을 40 mg/kg 수용성 덱사메타손 i.p.로 전처리했다. 2분 후, 각각 2개의 mAb 발현 카세트를 함유하는 2개의 플라스미드 각각 40 ug으로 마우스에 i.v. 투여했다.
첫 번째 처리 후 1, 8, 15, 21, 36, 50, 64, 78, 92 및 106일에 마우스를 채혈하고 mAb의 혈청 발현 수준을 인간 IgG ELISA 검정으로 분석했다. 결과는 도 70에 제시되어 있으며, 각 일련의 막대 그래프는 왼쪽에서 오른쪽 순서로 1, 8, 15, 21, 36, 50, 64, 78, 92 및 106일에 평균 +/- SEM mAb 발현(왼쪽 y축)을 나타낸다. 동시에, SARS-CoV2 스파이크 - 인간 ACE2 단백질 상호작용을 억제하는 SARS-CoV2- 특이적 mAb 함유 혈청의 기능적 능력은 시간 경과에 따라 상업적으로 이용가능한 시험관내 SARS-CoV2 스파이크/ACE2 차단 검정(cPASS, Genscript)에 의해 결정되었다. 막대 그래프의 각 시리즈는 1, 8, 15, 21, 36, 50, 78, 92 및 106일에 평균 +/- SEM mAb 억제(오른쪽 y축)를 나타낸다.
실시예 27
1회 주입으로 4개의 항-SARS-CoV2 mAbs 발현
이 실시예는 다음 프로토콜을 사용하여 도 71(서열 정보는 표 7 참조)에 표시된 4개의 항-SARS-CoV2 mAb의 발현을 설명한다. 0일에, 각각 1000 nmol의 DOTAP/2.5 mol% 덱사메타손 팔미테이트/SUV 및 DMPC/5 mol% 덱사메타손 팔미테이트/MLV를 구성하는 리포좀으로 i.v. 투여 2시간 전에, 마우스 군을 40 mg/kg 수용성 덱사메타손 i.p.로 전처리했다. 2분 후, 각각 2개의 mAb 발현 카세트를 포함하는 2개의 플라스미드 각각 40 ug으로 마우스에 i.v. 투여했다.
첫 번째 처리 후 1, 8, 15, 21, 36, 50, 64, 78, 및 92일에 마우스를 채혈하고 mAb의 혈청 발현 수준을 인간 IgG ELISA 검정으로 분석했다. 결과는 도 71에 제시되어 있으며, 각 일련의 막대 그래프는 왼쪽에서 오른쪽 순서로 1, 8, 15, 21, 36, 50, 64, 78, 및 92일에 평균 +/- SEM mAb 발현(왼쪽 y축)을 나타낸다. 동시에, SARS-CoV2 스파이크 - 인간 ACE2 단백질 상호작용을 억제하는 SARS-CoV2-특이적 mAb 함유 혈청의 기능적 능력은 시간 경과에 따라 상업적으로 이용가능한 시험관내 SARS-CoV2 스파이크/ACE2 차단 검정(cPASS, Genscript)에 의해 결정되었다. 막대 그래프의 각 시리즈(도 71에서 녹색)는 왼쪽에서 오른쪽 순서로 1, 8, 15, 21, 36, 50, 64, 78, 및 92일에 평균 +/- SEM mAb 억제(오른쪽 y축)를 나타낸다.
실시예 28
4개의 항-SARS-CoV2 mAbs 발현
이 실시예는 다음 프로토콜을 사용하여 도 72(서열 정보는 표 7 참조)에 표시된 4개의 항-SARS-CoV2 mAb의 발현을 설명한다. 0일에, 각각 1000 nmol의 DOTAP/2.5 mol% 덱사메타손 팔미테이트/SUV 및 DMPC/5 mol% 덱사메타손 팔미테이트/MLV를 구성하는 리포좀으로 i.v. 투여 2시간 전에, 마우스 군을 40 mg/kg 수용성 덱사메타손 i.p.로 전처리했다. 2분 후, 각각 2개의 mAb 발현 카세트를 포함하는 2개의 플라스미드 각각 45 ug으로 마우스에 i.v. 투여했다.
첫 번째 처리 후 1, 8, 22, 36, 50, 64, 78, 및 99일에 마우스를 채혈하고 mAb의 혈청 발현 수준을 인간 IgG ELISA 검정으로 분석했다. 결과는 도 72에 제시되어 있으며, 각 일련의 막대 그래프는 왼쪽에서 오른쪽 순서로 1, 8, 22, 36, 50, 64, 78, 및 99일에 평균 +/- SEM mAb 발현(왼쪽 y축)을 나타낸다. 동시에, SARS-CoV2 스파이크 - 인간 ACE2 단백질 상호작용을 억제하는 SARS-CoV2-특이적 mAb 함유 혈청의 기능적 능력은 시간 경과에 따라 상업적으로 이용가능한 시험관내 SARS-CoV2 스파이크/ACE2 차단 검정(cPASS, Genscript)에 의해 결정되었다. 결과는 녹색으로 표시되고, 막대 그래프의 각 시리즈는 1, 8, 22, 36, 50, 64, 78, 및 99일에 평균 +/- SEM mAb 억제(오른쪽 y축)를 나타낸다.
이러한 실시예는 각각 두 개의 상이한 개별 SARS-CoV2-특이적 mAbs를 암호화하는 2개의 상이한 단일 DNA 발현 플라스미드의 단일 동시 주입(동시 주입으로 총 4개의 상이한 개별 SARS-CoV2-특이적 mAb 생성)이 투여 후 적어도 90일 동안 4가지 상이한 SARS-CoV2-특이적 mAb의 혈청 수준의 완전히 중화 생성함을 보여주며, 이러한 진행 중인 혈청 mAb 수준은 기능적으로 지속적으로 SARS-CoV2 스파이크 - 인간 ACE2 결합을 적어도 90일 동안 차단했으며, 이는 인간의 경우 15년 이상에 해당한다.
실시예 29
2회 주입으로 4개의 항-SARS-CoV2 mAbs 발현
이 실시예는 다음 프로토콜을 사용하여 도 73(서열 정보는 표 7 참조)에 표시된 4개의 항-SARS-CoV2 mAb의 발현을 설명한다. 0일에, 각각 1000 nmol의 DOTAP/2.5 mol% 덱사메타손 팔미테이트/SUV 및 DMPC/5 mol% 덱사메타손 팔미테이트/MLV를 구성하는 리포좀으로 i.v. 투여 2시간 전에, 마우스 군을 40 mg/kg 수용성 덱사메타손 i.p.로 전처리했다. 2분 후, SARS-CoV2-특이적 mAb에 대한 2개의 발현 카세트를 함유하는 단일 플라스미드 80 ug으로 마우스에 i.v. 투여했다.
7일째에, 마우스는 0일과 같이 덱사메타손 전처리, 리포좀 투여 및 플라스미드 DNA의 추가 주입을 받았다(해시 막대로 표시됨). 마우스를 SARS-CoV2-특이적 mAb에 대한 발현 카세트 2개가 함유된 단일 플라스미드 DNA 80 ug으로 처리했다.
첫 번째 치료 후 1, 8, 15, 21, 36, 50, 64, 78, 92, 106, 120일에 마우스를 채혈하고 mAb의 혈청 발현 수준을 인간 IgG ELISA 검정으로 분석했다. 결과는 도 73에 제시되어 있으며, 각 일련의 막대 그래프는 왼쪽에서 오른쪽 순서로 1, 8, 15, 21, 36, 50, 64, 78, 92, 106, 120일에 평균 +/- SEM mAb 발현(왼쪽 y축)을 나타낸다. 동시에, SARS-CoV2 스파이크 - 인간 ACE2 단백질 상호작용을 억제하는 SARS-CoV2-특이적 mAb 함유 혈청의 기능적 능력은 시간 경과에 따라 상업적으로 이용가능한 시험관내 SARS-CoV2 스파이크/ACE2 차단 검정(cPASS, Genscript)에 의해 결정되었다. 각각의 일련의 막대 그래프(도 73에서 녹색)는 1, 8, 15, 21, 36, 50, 78, 92, 106, 120일에 평균 +/- SEM mAb 억제(오른쪽 y축)를 나타낸다.
실시예 30
2회 주입으로 4개의 항-SARS-CoV2 mAbs 발현
이 실시예는 다음 프로토콜을 사용하여 도 74(서열 정보는 표 7 참조)에 표시된 4개의 항-SARS-CoV2 mAb의 발현을 설명한다. 0일에, 각각 1000 nmol의 DOTAP/2.5 mol% 덱사메타손 팔미테이트/SUV 및 DMPC/5 mol% 덱사메타손 팔미테이트/MLV를 구성하는 리포좀으로 i.v. 투여 2시간 전에, 마우스 군을 40 mg/kg 수용성 덱사메타손 i.p.로 전처리했다. 2분 후, 각각 2개의 SARS-CoV2-특이적 mAb에 대한 발현 카세트를 함유하는 단일 플라스미드 80 ug으로 마우스에 i.v. 투여했다.
7일째에, 이들 군중 일부 마우스는 0일과 같이 덱사메타손 전처리, 리포좀 투여 및 플라스미드 DNA의 추가 주입을를 받았다(도트 채우기 패턴으로 표시). 이들 군을 2개의 mAb 발현 카세트가 함유된 2개 플라스미드 DNA의 각각 40 ug으로 처리했다. 첫 번째 치료 후 1, 8, 15, 21, 36, 50, 64, 78, 및 92일에 마우스를 채혈하고 SARS-CoV2 mAb의 혈청 발현 수준을 인간 IgG ELISA 검정으로 분석했다. 결과는 도 74에 제시되어 있으며, 각 일련의 막대 그래프는 왼쪽에서 오른쪽 순서로 1, 8, 15, 21, 36, 50, 64, 78, 92일에 평균 +/- SEM mAb 발현(왼쪽 y축)을 나타낸다. 동시에, SARS-CoV2 스파이크 - 인간 ACE2 단백질 상호작용을 억제하는 SARS-CoV2- 특이적 mAb 함유 혈청의 기능적 능력은 시간 경과에 따라 상업적으로 이용가능한 시험관내 SARS-CoV2 스파이크/ACE2 차단 검정(cPASS, Genscript)에 의해 결정되었다. 각각의 일련의 막대 그래프(녹색)는 왼쪽에서 오른쪽 순서로 1, 8, 15, 21, 36, 50, 64, 78, 및 92일에 평균 +/- SEM mAb 억제(오른쪽 y축)를 나타낸다.
이러한 실시예는 각각 두 개의 상이한 개별 SARS-CoV2-특이적 mAbs를 암호화하는 2개의 상이한 단일 DNA 발현 플라스미드의 단일 매주 동시 주입(동시 주입으로 총 4개의 상이한 개별 SARS-CoV2-특이적 mAb 생성)이 투여 후 적어도 70일 동안 4가지 상이한 SARS-CoV2-특이적 mAb의 혈청 수준의 완전한 중화를 생성함을 보여주며, 이러한 진행 중인 혈청 mAb 수준은 기능적으로 지속적으로 SARS-CoV2 스파이크 - 인간 ACE2 결합을 최소 70일 동안 차단했으며, 이는 인간의 경우 10년 이상에 해당한다.
실시예 31
2회 주입으로 5개의 항-SARS-CoV2 mAb 발현
이 실시예는 다음 프로토콜을 사용하여 도 75(서열 정보는 표 7 참조)에 표시된 5개의 항-SARS-CoV2 mAb의 발현을 설명한다. 0일에, 각각 1000 nmol의 DOTAP/2.5 mol% 덱사메타손 팔미테이트/SUV 및 DMPC/5 mol% 덱사메타손 팔미테이트/MLV를 구성하는 리포좀으로 i.v. 투여 2시간 전에, 마우스 군을 40 mg/kg 수용성 덱사메타손 i.p.로 전처리했다. 2분 후, SARS-CoV2-특이적 mAb에 대한 하나의 발현 카세트를 함유하는 단일 플라스미드 80 ug으로 마우스에 i.v. 투여했다.
7일에, 마우스 군은 0일과 같이 덱사메타손 전처리, 리포좀 투여 및 플라스미드 DNA의 추가 주사를 받았다. 일부 군을 각각 mAbs 발현 카세트 2개가 함유된 2개의 플라스미드 DNA 40 ug으로 처리했다.
첫 번째 처리 후 1, 8, 15, 21, 36, 50, 64, 78, 92, 106, 120일에 마우스를 채혈하고 mAb의 혈청 발현 수준을 인간 IgG ELISA 검정으로 분석했다. 결과는 도 75에 제시되어 있으며, 각 일련의 막대 그래프는 왼쪽에서 오른쪽 순서로 1, 8, 15, 21, 36, 50, 64, 78, 92, 106, 120일에 평균 +/- SEM mAb 발현(왼쪽 y축)을 나타낸다. 동시에, SARS-CoV2 스파이크 - 인간 ACE2 단백질 상호작용을 억제하는 SARS-CoV2-특이적 mAb 함유 혈청의 기능적 능력은 시간 경과에 따라 상업적으로 이용가능한 시험관내 SARS-CoV2 스파이크/ACE2 차단 검정(cPASS, Genscript)에 의해 결정되었다. 각각의 일련의 막대 그래프(도 75에서 녹색)는 1, 8, 15, 21, 36, 50, 78, 92, 106, 120일에 평균 +/- SEM mAb 억제(오른쪽 y축)를 나타낸다.
실시예 32
단회 주입으로 6개의 항-SARS-CoV2 mAbs 발현
이 실시예는 다음 프로토콜을 사용하여 도 76(서열 정보는 표 7 참조)에 표시된 6개의 항-SARS-CoV2 mAb의 발현을 설명한다. 0일에, 각각 1000 nmol의 DOTAP/2.5 mol% 덱사메타손 팔미테이트/SUV 및 DMPC/5 mol% 덱사메타손 팔미테이트/MLV를 구성하는 리포좀으로 i.v. 투여 2시간 전에, 마우스 군을 40 mg/kg 수용성 덱사메타손 i.p.로 전처리했다. 2분 후, 각각 2개의 mAbs 발현 카세트를 함유하는 각각 3개의 플라스미드 30 ug으로 마우스에 i.v. 투여했다.
첫 번째 치료 후 1, 8, 22, 36, 50, 64, 78, 99일에 마우스를 채혈하고 mAb의 혈청 발현 수준을 인간 IgG ELISA 검정으로 분석했다. 결과는 도 76에 제시되어 있으며, 각 일련의 막대 그래프는 왼쪽에서 오른쪽 순서로 1, 8, 22, 36, 50, 64, 78, 99일에 평균 +/- SEM mAb 발현(왼쪽 y축)을 나타낸다. 동시에, SARS-CoV2 스파이크 - 인간 ACE2 단백질 상호작용을 억제하는 SARS-CoV2-특이적 mAb 함유 혈청의 기능적 능력은 시간 경과에 따라 상업적으로 이용가능한 시험관내 SARS-CoV2 스파이크/ACE2 차단 검정(cPASS, Genscript)에 의해 결정되었다. 각각의 일련의 막대 그래프(도 76에서 녹색)는 1, 8, 22, 36, 50, 64, 78, 99일에 평균 +/- SEM mAb 억제(오른쪽 y축)를 나타낸다.
실시예 33
2회 주입으로 6개의 항-SARS-CoV2 mAbs 발현
이 실시예는 다음 프로토콜을 사용하여 도 77(서열 정보는 표 7 참조)에 표시된 6개의 항-SARS-CoV2 mAb의 발현을 설명한다. 0일에, 각각 1000 nmol의 DOTAP/2.5 mol% 덱사메타손 팔미테이트/SUV 및 DMPC/5 mol% 덱사메타손 팔미테이트/MLV를 구성하는 리포좀으로 i.v. 투여 2시간 전에, 마우스 군을 40 mg/kg 수용성 덱사메타손 i.p.로 전처리했다. 2분 후, 2개의 SARS-CoV2 특이적 mAbs에 대한 발현 카세트를 함유하는 단일 플라스미드 80 ug, 또는 각각 1개 또는 2개의 mAbs 발현 카세트를 함유하는 각각 2개 플라스미드 40 ug으로 마우스에 i.v. 투여했다.
7일에, 이들 군의 마우스는 0일과 같이 덱사메타손 전처리, 리포좀 투여 및 플라스미드 DNA의 추가 주입을 받았다. 이들 군을 2개의 mAbs 발현 카세트를 함유하는 단일 플라스미드 80 ug, 또는 각각 2개의 mAbs 발현 카세트를 함유하는 각각 2개 플라스미드 40 ug으로 처리했다.
첫 번째 치료 후 1, 8, 15, 21, 36, 50, 64, 78, 92, 106, 120일에 마우스를 채혈하고 mAb의 혈청 발현 수준을 인간 IgG ELISA 검정으로 분석했다. 결과는 도 77에 제시되어 있으며, 각 일련의 막대 그래프는 왼쪽에서 오른쪽 순서로 1, 8, 15, 21, 36, 50, 64, 78, 92, 106, 120일에 평균 +/- SEM mAb 발현(왼쪽 y축)을 나타낸다. 동시에, SARS-CoV2 스파이크 - 인간 ACE2 단백질 상호작용을 억제하는 SARS-CoV2-특이적 mAb 함유 혈청의 기능적 능력은 시간 경과에 따라 상업적으로 이용가능한 시험관내 SARS-CoV2 스파이크/ACE2 차단 검정(cPASS, Genscript)에 의해 결정되었다. 각각의 일련의 막대 그래프(도 77에서 녹색)는 1, 8, 15, 21, 36, 50, 78, 92, 106, 120일에 평균 +/- SEM mAb 억제(오른쪽 y축)를 나타낸다.
실시예 34
2회 또는 3회 주입으로 6개의 항-SARS-CoV2 mAbs 발현
이 실시예는 다음 프로토콜을 사용하여 도 78(서열 정보는 표 7 참조)에 표시된 6개의 항-SARS-CoV2 mAb의 발현을 설명한다. 0일에, 각각 1000 nmol의 DOTAP/2.5 mol% 덱사메타손 팔미테이트/SUV 및 DMPC/5 mol% 덱사메타손 팔미테이트/MLV를 구성하는 리포좀으로 i.v. 투여 2시간 전에, 마우스 군을 40 mg/kg 수용성 덱사메타손 i.p.로 전처리했다. 2분 후, SARS-CoV2 특이적 mAbs에 대한 발현 카세트 2개를 함유하는 단일 플라스미드 80 ug, 또는 각각 1개 또는 2개의 mAbs 발현 카세트를 함유하는 각각 2개 플라스미드 40 ug으로 마우스에 i.v. 투여했다.
7일에, 이들 군의 마우스는 0일과 같이 덱사메타손 전처리, 리포좀 투여 및 플라스미드 DNA의 추가 주입을 받았다(도트 채우기 패턴으로 표시). 이들 군을 2개의 mAbs 발현 카세트를 함유하는 각각 2개 플라스미드 40 ug으로 처리했다.
14일에, 이들 마우스 군 중 일부는 0일과 같이 덱사메타손 전처리, 리포좀 투여, 플라스미드 DNA의 3 라운드 주입을 받았다. 이 군은 SARS-CoV2-특이적 mAb에 대한 2개의 발현 카세트를 함유하는 80 ug의 단일 플라스미드 DNA로 처리되었다.
첫 번째 치료 후 1, 8, 15, 21, 36, 50, 64, 78, 92일에 마우스를 채혈하고 SARS-CoV2 mAb의 혈청 발현 수준을 인간 IgG ELISA 검정으로 분석했다. 결과는 도 78에 제시되어 있으며, 각 일련의 막대 그래프는 왼쪽에서 오른쪽 순서로 1, 8, 15, 21, 36, 50, 64, 78, 92일에 평균 +/- SEM mAb 발현(왼쪽 y축)을 나타낸다. 동시에, SARS-CoV2 스파이크 - 인간 ACE2 단백질 상호작용을 억제하는 SARS-CoV2-특이적 mAb 함유 혈청의 기능적 능력은 시간 경과에 따라 상업적으로 이용가능한 시험관내 SARS-CoV2 스파이크/ACE2 차단 검정(cPASS, Genscript)에 의해 결정되었다. 각각의 일련의 막대 그래프(도 78에서 녹색)는 왼쪽에서 오른쪽 순서로 1, 8, 15, 21, 36, 50, 64, 78, 92일에 평균 +/- SEM mAb 억제(오른쪽 y축)를 나타낸다.
이러한 실시예는 각각 두 개의 상이한 개별 SARS-CoV2-특이적 mAbs를 암호화하는 3개의 상이한 단일 DNA 발현 플라스미드의 일련의 동시 주입(동시 주입으로 총 6개의 상이한 개별 SARS-CoV2-특이적 mAb 생성)이 투여 후 적어도 90일 동안 6가지 상이한 SARS-CoV2-특이적 mAb의 혈청 수준의 완전한 중화를 생성함을 보여주며, 이러한 진행 중인 혈청 mAb 수준은 기능적으로 지속적으로 SARS-CoV2 스파이크 - 인간 ACE2 결합을 적어도 90일 동안 차단했으며, 이는 인간의 경우 15년 이상에 해당한다.
실시예 35
2회 주입으로 8개의 항-SARS-CoV2 mAbs 발현
이 실시예는 다음 프로토콜을 사용하여 도 79(서열 정보는 표 7 참조)에 표시된 8개의 항-SARS-CoV2 mAb의 발현을 설명한다. 0일에, 각각 1000 nmol의 DOTAP/2.5 mol% 덱사메타손 팔미테이트/SUV 및 DMPC/5 mol% 덱사메타손 팔미테이트/MLV를 구성하는 리포좀으로 i.v. 투여 2시간 전에, 마우스 군을 40 mg/kg 수용성 덱사메타손 i.p.로 전처리했다. 2분 후, 2개의 mAbs 발현 카세트를 각각 함유하는 각각 2개 플라스미드 40 ug으로 마우스에 i.v. 투여했다.
7일에, 마우스는 0일과 같이 덱사메타손 전처리, 리포좀 투여 및 플라스미드 DNA의 추가 주입을 받았다. 마우스를 2개의 mAbs 발현 카세트를 함유하는 각각 2개 플라스미드 40 ug으로 처리했다.
첫 번째 치료 후 1, 8, 15, 21, 36, 50, 64, 78, 92, 106, 120일에 마우스를 채혈하고 mAb의 혈청 발현 수준을 인간 IgG ELISA 검정으로 분석했다. 결과는 도 79에 제시되어 있으며, 각 일련의 막대 그래프는 왼쪽에서 오른쪽 순서로 1, 8, 15, 21, 36, 50, 64, 78, 92, 106, 120일에 평균 +/- SEM mAb 발현(왼쪽 y축)을 나타낸다. 동시에, SARS-CoV2 스파이크 - 인간 ACE2 단백질 상호작용을 억제하는 SARS-CoV2-특이적 mAb 함유 혈청의 기능적 능력은 시간 경과에 따라 상업적으로 이용가능한 시험관내 SARS-CoV2 스파이크/ACE2 차단 검정(cPASS, Genscript)에 의해 결정되었다. 각각의 일련의 막대 그래프(도 79에서 녹색)는 1, 8, 15, 21, 36, 50, 78, 92, 106, 120일에 평균 +/- SEM mAb 억제(오른쪽 y축)를 나타낸다.
실시예 36
2회 주입으로 8개의 항-SARS-CoV2 mAbs 발현
이 실시예는 다음 프로토콜을 사용하여 도 80(서열 정보는 표 7 참조)에 표시된 8개의 항-SARS-CoV2 mAb의 발현을 설명한다. 0일에, 각각 1000 nmol의 DOTAP/2.5 mol% 덱사메타손 팔미테이트/SUV 및 DMPC/5 mol% 덱사메타손 팔미테이트/MLV를 구성하는 리포좀으로 i.v. 투여 2시간 전에, 마우스 군을 40 mg/kg 수용성 덱사메타손 i.p.로 전처리했다. 2분 후, 2개의 mAbs 발현 카세트를 함유하는 각각 2개 플라스미드 40 ug으로 마우스에 i.v. 투여했다.
7일에, 마우스는 0일과 같이 덱사메타손 전처리, 리포좀 투여 및 플라스미드 DNA의 추가 주입을 받았다. 마우스를 각각 2개의 mAbs 발현 카세트를 함유하는 각각 2개 플라스미드 40 ug으로 처리했다.
첫 번째 처리 후 1, 8, 15, 21, 36, 50, 64, 78, 92일에 마우스를 채혈하고 mAb의 혈청 발현 수준을 인간 IgG ELISA 검정으로 분석했다. 결과는 도 80에 제시되어 있으며, 각 일련의 막대 그래프는 왼쪽에서 오른쪽 순서로 1, 8, 15, 21, 36, 50, 64, 78, 92일에 평균 +/- SEM mAb 발현(왼쪽 y축)을 나타낸다. 동시에, SARS-CoV2 스파이크 - 인간 ACE2 단백질 상호작용을 억제하는 SARS-CoV2-특이적 mAb 함유 혈청의 기능적 능력은 시간 경과에 따라 상업적으로 이용가능한 시험관내 SARS-CoV2 스파이크/ACE2 차단 검정(cPASS, Genscript)에 의해 결정되었다. 각각의 일련의 막대 그래프(도 80에서 녹색)는 왼쪽에서 오른쪽 순서로 1, 8, 15, 21, 36, 50, 64, 78, 92일에 평균 +/- SEM mAb 억제(오른쪽 y축)를 나타낸다.
실시예 37
3회 주입으로 8개의 항-SARS-CoV2 mAbs 발현
이 실시예는 다음 프로토콜을 사용하여 도 81(서열 정보는 표 7 참조)에 표시된 8개의 항-SARS-CoV2 mAb의 발현을 설명한다. 0일에, 각각 1000 nmol의 DOTAP/2.5 mol% 덱사메타손 팔미테이트/SUV 및 DMPC/5 mol% 덱사메타손 팔미테이트/MLV를 구성하는 리포좀으로 i.v. 투여 2시간 전에, 마우스 군을 40 mg/kg 수용성 덱사메타손 i.p.로 전처리했다. 2분 후, 각각 2개의 mAb 발현 카세트를 함유하는 각각 2개 플라스미드 40 ug으로 마우스에 i.v. 투여했다.
7일에, 마우스는 0일과 같이 덱사메타손 전처리, 리포좀 투여 및 플라스미드 DNA의 2 라운드 주입을 받았다. 이들 군을 SARS-CoV2-특이적 mAbs에 대한 2개의 발현 카세트를 함유하는 단일의 플라스미드 80 ug으로 처리했다.
14일에, 이들 마우스는 0일과 같이 덱사메타손 전처리, 리포좀 투여, 플라스미드 DNA의 3 라운드 주입을 받았다(해시 막대로 표시). 이 군은 2개의 mAb 발현 카세트를 함유하는 80 ug의 단일 플라스미드 DNA로 처리되었다.
첫 번째 치료 후 1, 8, 15, 21, 36, 50, 64, 78, 92일에 마우스를 채혈하고 SARS-CoV2 mAb의 혈청 발현 수준을 인간 IgG ELISA 검정으로 분석했다. 결과는 도 81에 제시되어 있으며, 각 일련의 막대 그래프는 왼쪽에서 오른쪽 순서로 1, 8, 15, 21, 36, 50, 64, 78, 92일에 평균 +/- SEM mAb 발현(왼쪽 y축)을 나타낸다. 동시에, SARS-CoV2 스파이크 - 인간 ACE2 단백질 상호작용을 억제하는 SARS-CoV2-특이적 mAb 함유 혈청의 기능적 능력은 시간 경과에 따라 상업적으로 이용가능한 시험관내 SARS-CoV2 스파이크/ACE2 차단 검정(cPASS, Genscript)에 의해 결정되었다. 각각의 일련의 막대 그래프(도 81에서 녹색)는 왼쪽에서 오른쪽 순서로 1, 8, 15, 21, 36, 50, 64, 78, 92일에 평균 +/- SEM mAb 억제(오른쪽 y축)를 나타낸다.
실시예 38
8개의 항-SARS-CoV2 mAbs 발현
이 실시예는 다음 프로토콜을 사용하여 도 82(서열 정보는 표 7 참조)에 표시된 8개의 항-SARS-CoV2 mAb의 발현을 설명한다. 0일에, 각각 1000 nmol의 DOTAP/2.5 mol% 덱사메타손 팔미테이트/SUV 및 DMPC/5 mol% 덱사메타손 팔미테이트/MLV를 구성하는 리포좀으로 i.v. 투여 2시간 전에, 마우스 군을 40 mg/kg 수용성 덱사메타손 i.p.로 전처리했다. 2분 후, 각각 1개 또는 2개의 mAb 발현 카세트를 함유하는 각각 2개 플라스미드 40 ug으로 마우스에 i.v. 투여했다.
7일에, 마우스는 0일과 같이 덱사메타손 전처리, 리포좀 투여 및 플라스미드 DNA의 2 라운드 주입을 받았다. 이들 군을 2개의 SARS-CoV2-특이적 mAb 발현 카세트를 함유하는 단일의 플라스미드 80 ug, 또는 각각 2개의 mAb 발현 카세트를 함유하는 각각 2개의 플라스미드 40 ug으로 처리했다.
14일에, 이들 마우스 군 중 일부는 0일과 같이 덱사메타손 전처리, 리포좀 투여, 플라스미드 DNA의 3 라운드 주입을 받았다(해시 막대로 표시). 이 군은 2개의 SARS-CoV2-특이적 mAb 발현 카세트를 함유하는 80 ug의 단일 플라스미드 DNA로 처리되었다.
첫 번째 치료 후 1, 8, 15, 21, 36, 50, 64, 78, 92일에 마우스를 채혈하고 SARS-CoV2 mAb의 혈청 발현 수준을 인간 IgG ELISA 검정으로 분석했다. 결과는 도 82에 제시되어 있으며, 각 일련의 막대 그래프는 왼쪽에서 오른쪽 순서로 1, 8, 15, 21, 36, 50, 64, 78, 92일에 평균 +/- SEM mAb 발현(왼쪽 y축)을 나타낸다. 동시에, SARS-CoV2 스파이크 - 인간 ACE2 단백질 상호작용을 억제하는 SARS-CoV2-특이적 mAb 함유 혈청의 기능적 능력은 시간 경과에 따라 상업적으로 이용가능한 시험관내 SARS-CoV2 스파이크/ACE2 차단 검정(cPASS, Genscript)에 의해 결정되었다. 각각의 일련의 막대 그래프(도 82에서 녹색)는 왼쪽에서 오른쪽 순서로 1, 8, 15, 21, 36, 50, 64, 78, 92일에 평균 +/- SEM mAb 억제(오른쪽 y축)를 나타낸다.
실시예 39
다른 단백질 및 mAb와 함께 10개의 항-SARS-CoV2 mAbs 발현
이 실시예는 다음 프로토콜을 사용하여 도 83(서열 정보는 표 7 참조)에 표시된 10개의 항-SARS-CoV2 mAb, 및 다른 단백질 및 mAb의 발현을 설명한다. 0일에, 각각 1000 nmol의 DOTAP/2.5 mol% 덱사메타손 팔미테이트/SUV 및 DMPC/5 mol% 덱사메타손 팔미테이트/MLV를 구성하는 리포좀으로 i.v. 투여 2시간 전에, 마우스 군을 40 mg/kg 수용성 덱사메타손 i.p.로 전처리했다. 2분 후, 각각 1개 또는 2개의 mAbs 발현 카세트를 함유하는 각각 2개 플라스미드 40 ug으로 마우스에 i.v. 투여했다.
7일에, 마우스는 0일과 같이 덱사메타손 전처리, 리포좀 투여 및 플라스미드 DNA의 2 라운드 주입을를 받았다(해시 막대로 표시). 이들 군을 각각 2개의 mAbs 발현 카세트를 함유하는 각각 2개의 플라스미드 40 ug으로 처리했다.
14일에, 이들 마우스 군 중 일부는 0일과 같이 덱사메타손 전처리, 리포좀 투여, 플라스미드 DNA의 3 라운드 주입을 받았다. 이 군은 SARS-CoV2-특이적 mAb 클론을 위한 2개의 발현 카세트를 함유하는 80 ug의 단일 플라스미드 DNA로 처리되었다.
21일에, 이들 마우스 군 중 일부는 0일과 같이 덱사메타손 전처리, 리포좀 투여 및 플라스미드 DNA의 4 라운드 주입을 받았다. 이 군은 비-SARS-CoV2-관련 단백질에 대한 2개의 발현 카세트를 함유하는 80 ug의 단일 플라스미드 DNA로 처리되었다. 이러한 비-SARS-CoV2-관련 단백질에는 메폴루지맙(aIL5) 및 항-인플루엔자 A 헤마글루티닌 H1(5J8)이 포함되었다.
첫 번째 치료 후 1, 8, 15, 21, 36, 50, 64, 78, 92일에 마우스를 채혈하고 SARS-CoV2 mAb의 혈청 발현 수준을 인간 IgG ELISA 검정으로 분석했다. 결과는 도 83에 제시되어 있으며, 각 일련의 막대 그래프는 왼쪽에서 오른쪽 순서로 1, 8, 15, 21, 36, 50, 64, 78, 92일에 평균 +/- SEM mAb 발현(왼쪽 y축)을 나타낸다. 동시에, SARS-CoV2 스파이크 - 인간 ACE2 단백질 상호작용을 억제하는 SARS-CoV2-특이적 mAb 함유 혈청의 기능적 능력은 시간 경과에 따라 상업적으로 이용가능한 시험관내 SARS-CoV2 스파이크/ACE2 차단 검정(cPASS, Genscript)에 의해 결정되었다. 각각의 일련의 막대 그래프(도 83에서 녹색)는 왼쪽에서 오른쪽 순서로 1, 8, 15, 21, 36, 50, 64, 78, 92일에 평균 +/- SEM mAb 억제(오른쪽 y축)를 나타낸다.
실시예 40
다른 단백질 및 mAb와 함께 11개의 항-SARS-CoV2 mAbs 발현
이 실시예는 다음 프로토콜을 사용하여 도 84(서열 정보는 표 7 참조)에 표시된 11개의 항-SARS-CoV2 mAb, 및 다른 단백질 및 mAb의 발현을 설명한다. 0일에, 각각 1000 nmol의 DOTAP/2.5 mol% 덱사메타손 팔미테이트/SUV 및 DMPC/5 mol% 덱사메타손 팔미테이트/MLV를 구성하는 리포좀으로 i.v. 투여 2시간 전에, 마우스 군을 40 mg/kg 수용성 덱사메타손 i.p.로 전처리했다. 2분 후, 2개의 mAb 발현 카세트를 함유하는 각각 2개 플라스미드 40 ug으로 마우스에 i.v. 투여했다.
7일에, 마우스는 0일과 같이 덱사메타손 전처리, 리포좀 투여 및 플라스미드 DNA의 2 라운드 주입을 받았다. 이들 군을 각각 2개의 mAb 발현 카세트를 함유하는 각각 2개의 플라스미드 40 ug으로 처리했다.
14일에, 이들 마우스 군은 0일과 같이 덱사메타손 전처리, 리포좀 투여, 플라스미드 DNA의 3 라운드 주입을 받았다. 이 군은 2개의 mAb 발현 카세트를 함유하는 40 ug의 각각 2개의 플라스미드 DNA로 처리되었다.
21일에, 이들 마우스 군은 0일과 같이 덱사메타손 전처리, 리포좀 투여 및 플라스미드 DNA의 4 라운드 주입을 받았다. 이 군은 비-SARS-CoV2-관련 단백질에 대한 2개 이상의 발현 카세트를 함유하는 80 ug의 단일 플라스미드 DNA, 2개의 비-SARS-CoV2-관련 단백질을 함유하는 2개의 40 ug의 플라스미드 DNA, 또는 2개의 비-SARS-CoV2-관련 단백질을 함유하는 2개의 25 ug의 플라스미드 DNA로 처리되었다. 이러한 비-SARS-CoV2-관련 단백질에는 인간 성장 호르몬(GH), 갈락토시다제 알파(GLA), G-CSF 및 mAbs 리툭시맙(aCD20), 메폴루지맙(aIL5) 및 항-인플루엔자 A 헤마글루티닌 H1(5J8)이 포함되었다.
첫 번째 치료 후 1, 8, 15, 21, 36, 50, 64, 78, 92일에 마우스를 채혈하고 SARS-CoV2 mAb의 혈청 발현 수준을 인간 IgG ELISA 검정으로 분석했다. 결과는 도 84에 제시되어 있으며, 각 일련의 막대 그래프는 왼쪽에서 오른쪽 순서로 1, 8, 15, 21, 36, 50, 64, 78, 92일에 평균 +/- SEM mAb 발현(왼쪽 y축)을 나타낸다. 동시에, SARS-CoV2 스파이크 - 인간 ACE2 단백질 상호작용을 억제하는 SARS-CoV2-특이적 mAb 함유 혈청의 기능적 능력은 시간 경과에 따라 상업적으로 이용가능한 시험관내 SARS-CoV2 스파이크/ACE2 차단 검정(cPASS, Genscript)에 의해 결정되었다. 각각의 일련의 막대 그래프(도 84에서 녹색)는 왼쪽에서 오른쪽 순서로 1, 8, 15, 21, 36, 50, 64, 78, 92일에 평균 +/- SEM mAb 억제(오른쪽 y축)를 나타낸다.
이러한 실시예는 두 개의 상이한 개별 SARS-CoV2-특이적 mAbs를 암호화하는 최대 6개의 상이한 단일 DNA 발현 플라스미드의 일련의 동시-주입(일련의 주입으로 총 최대 11개의 상이한 개별 SARS-CoV2 특이적 mAb 생성)이 투여 후 적어도 90일 동안 최대 11개의 상이한 SARS-CoV2 특이적 mAb의 혈청 수준의 완전한 중화를 생성함을 보여주며, 이러한 진행 중인 혈청 mAb 수준은 기능적으로 지속적으로 SARS-CoV2 스파이크 - 인간 ACE2 결합을 적어도 90일 동안 차단했으며, 이는 인간의 경우 15년 이상에 해당한다.
실시예 41
다른 단백질 및 mAb와 함께 10개의 항-SARS-CoV2 mAbs 발현
이 실시예는 다음 프로토콜을 사용하여 도 85(서열 정보는 표 7 참조)에 표시된 10개의 항-SARS-CoV2 mAb 및 다른 비-SARS-CoV2 mAb의 발현을 설명한다. 0일에, 각각 1000 nmol의 DOTAP/2.5 mol% 덱사메타손 팔미테이트/SUV 및 DMPC/5 mol% 덱사메타손 팔미테이트/MLV를 구성하는 리포좀으로 i.v. 투여 2시간 전에, 마우스 군을 40 mg/kg 수용성 덱사메타손 i.p.로 전처리했다. 2분 후, 2개의 mAbs 발현 카세트를 함유하는 각각 2개 플라스미드 40 ug으로 마우스에 i.v. 투여했다.
7일에, 마우스는 0일과 같이 덱사메타손 전처리, 리포좀 투여 및 플라스미드 DNA의 2 라운드 주입을 받았다(도트 채우기 패턴으로 표시됨). 이들 군을 각각 2개의 mAb 발현 카세트를 함유하는 각각 2개의 플라스미드 40 ug으로 처리했다.
14일에, 이들 마우스 군은 0일과 같이 덱사메타손 전처리, 리포좀 투여, 플라스미드 DNA의 3 라운드 주입을 받았다(해시 막대로 표시됨). 이 군은 SARS-CoV2-특이적 mAb에 대한 2개의 발현 카세트를 함유하는 80 ug의 단일의 플라스미드 DNA로 처리되었다.
21일에, 이들 마우스 군은 0일과 같이 덱사메타손 전처리, 리포좀 투여 및 플라스미드 DNA의 4 라운드 주입을 받았다. 이 군은 비-SARS-CoV2-관련 단백질에 대한 2개의 발현 카세트를 함유하는 80 ug의 단일 플라스미드 DNA로 처리되었다. 이러한 비-SARS-CoV2-관련 단백질에는 메폴루지맙 바이오실밀러(aIL5) 및 항-인플루엔자 A 헤마글루티닌 H1(5J8)이 포함되었다.
첫 번째 치료 후 1, 8, 15, 21, 36, 50, 64, 78, 92일에 마우스를 채혈하고 SARS-CoV2 mAb의 혈청 발현 수준을 인간 IgG ELISA 검정으로 분석했다. 결과는 도 85에 제시되어 있으며, 각 일련의 막대 그래프는 왼쪽에서 오른쪽 순서로 1, 8, 15, 21, 36, 50, 64, 78, 92일에 평균 +/- SEM mAb 발현(왼쪽 y축)을 나타낸다. 동시에, SARS-CoV2 스파이크 - 인간 ACE2 단백질 상호작용을 억제하는 SARS-CoV2-특이적 mAb 함유 혈청의 기능적 능력은 시간 경과에 따라 상업적으로 이용가능한 시험관내 SARS-CoV2 스파이크/ACE2 차단 검정(cPASS, Genscript)에 의해 결정되었다. 각각의 일련의 막대 그래프(도 85에서 녹색)는 왼쪽에서 오른쪽 순서로 1, 8, 15, 21, 36, 50, 64, 78, 92일에 평균 +/- SEM mAb 억제(오른쪽 y축)를 나타낸다.
이 실시예는 총 6개의 상이한 단일 DNA 발현 플라스미드의 연속 공동-주입을 보여주며, 이 중 5개는 2개의 상이한 개별 SARS-CoV2-특이적 mAb를 암호화하고 6번째는 1918년 팬데믹 인플루엔자 바이러스에 대해 지시된 mAb 5J8의 중쇄 및 경쇄 cDNA를 암호화한다. 이러한 일련의 주입은 총 10개의 상이한 개별 SARS-CoV2 특이적 혈청 mAb 단백질과 하나의 1918 팬데믹 인플루엔자 특이적 혈청 mAb 단백질의 중화 수준을 생성했다. 이러한 주입은 투여 후 적어도 90일 동안 10가지 상이한 모든 SARS-CoV2 특이적 mAb의 중화 혈청 수준과 1918년 팬데믹 인플루엔자 특이적 mAb의 중화 혈청 수준을 생성했으며, 이러한 진행 중인 SARS-CoV2 특이적 mAb 혈청 수준은 기능적으로 지속적으로 SARS-CoV2 스파이크 - 인간 ACE2 결합을 차단했다. 또한, 헤지 생산 항-팬데믹 인플루엔자 A mAb 5J8 혈청 수준은 Cal/09 팬데믹 인플루엔자 바이러스 균주를 적어도 90일 동안 중화시켰으며, 이는 인간이 15년 이상에 해당하는 기간이다. 이것은 총 4회의 일련의 DNA 벡터 투여가 이후 수십 년 동안 SARS-CoV-2 바이러스와 팬데믹 인플루엔자 바이러스를 중화시킬 수 있음을 의미한다.
실시예 42
치료 후 14시간까지 SARS-CoV2 억제.
이 실시예는 도 86에 표시된 항-SARS-CoV-2 mAbs로 처리 후 14시간까지 SARS-CoV2의 억제를 설명한다(서열 정보는 표 7 참조). 0일에, 각각 1000 nmol의 DOTAP/2.5 mol% 덱사메타손 팔미테이트/SUV 및 DMPC/5 mol% 덱사메타손 팔미테이트/MLV를 구성하는 리포좀으로 i.v. 투여 2시간 전에, 마우스 군을 40 mg/kg 수용성 덱사메타손 i.p.로 전처리했다. 2분 후, 1개 또는 2개의 SARS-CoV-2-특이적 mAbs에 대한 발현 카세트를 함유하는 단일의 플라스미드 80 ug으로 마우스에 i.v. 투여했다.
첫 번째 치료 후 1, 4, 8, 14, 18, 20, 24, 및 48시간에 마우스를 채혈하고 SARS-CoV2 mAb의 혈청 발현 수준을 인간 IgG ELISA 검정으로 분석했다. 결과는 도 86a에 제시되어 있으며, 각 일련의 막대 그래프는 지정된 시간(hr)에 평균 +/- SEM mAb 발현을 나타낸다. 동시에, SARS-CoV2 스파이크 - 인간 ACE2 단백질 상호작용을억제하는 SARS-CoV2 특이적 mAb 함유 혈청의 기능적 능력은 시간 경과에 따라 상업적으로 이용가능한 시험관내 SARS-CoV2 스파이크/ACE2 차단 검정(cPASS, Genscript)에 의해 결정되었다. 결과는 도 86b에 나타나 있으며, 각각의 일련의 막대 그래프는 처리 후 시간 단위로 표시된 시간에 평균 +/- SEM mAb 억제를 나타낸다.
이 실시예에서는 SARS-CoV2 스파이크-인간 ACE2 결합을 기능적으로 차단하기 위해 1개 또는 2개의 항 SARS-CoV-2 mAb 중쇄 및 경쇄 cDNA를 암호화하는 단일 항 SARS-CoV-2 DNA 벡터를 한 번 투여한 후 1시간에서 24시간 사이에 시간 경과에 따라 생성된 항-SARS-CoV-2 mAb 혈청 수준의 능력을 시간 경과에 따른 검정을 사용한다. 결과는 SARS-CoV2 스파이크 - 인간 ACE2 결합이 1개 또는 2개의 항-SARS-CoV-2 mAb를 암호화하는 1개의 IV 헤지 DNA 벡터 주입 후 8시간 이내에 효율적으로 차단됨을 보여준다. 대조적으로 두 가지 상이한 항 SARS-CoV-2 백신 투여 후 중화 보호에는 일반적으로 5주가 소요된다.
실시예 43
여러 다른 mAb 및 유전자의 동시 발현
이 실시예는 단일 주입을 사용하여 6개의 상이한 mAb 및 유전자의 동시 발현을 설명한다. 군당 4마리의 마우스에 40 mg/kg 수용성 덱사메타손을 IP 주입했다. 2시간 후, 도 87에 도시된 용량으로 2.5% 덱사메타손 21-팔미테이트를 함유하는 양이온성 리포좀 및 5% 덱스 팔미테이트를 함유하는 1000 nmol DMPC 리포좀으로 마우스를 i.v.로 주입했다. 첫 번째 i.v.로 주입 후 2분에, 각각의 3개의 DNA 플라스미드를 마우스에 각각 25 ug, 각각 30 ug 또는 각각 34 ug 주입했다: 하나는 항-IL5 및 5J8을 암화화하고, 하나는 hGH 및 hGCSF를 암호화하며, 다른 하나는 항-SARS-CoV2 및 GLA를 암호화한다. 다음 날 마우스에서 채혈하고 표적 유전자의 발현에 대해 혈청을 분석하였다. 발현 결과는 도 87에 제시되어 있다. 이 실시예는 각각 2개 또는 3개의 상이한 인간 유전자를 암호화하는 3개의 상이한 DNA 벡터의 단일 공동-주입이 6개의 상이한 인간 단백질 모두의 상당한 혈청 수준을 생성함을 입증한다.
실시예 44
다양한 진핵 프로모터를 사용한 제어된 유전자 발현
이 실시예는 표적 유전자(인간 성장 호르몬)를 발현하기 위한 다양한 진핵 프로모터의 사용을 설명한다. 0일에, 각각 1100 nmol의 DOTAP/2.5 mol% 덱사메타손 팔미테이트/SUV 및 DMPC/5 mol% 덱사메타손 팔미테이트/MLV를 구성하는 리포좀으로 i.v. 투여 2시간 전에, 마우스 군을 40 mg/kg 수용성 덱사메타손 i.p.로 전처리했다. 2분 후, 도 88에 나타낸 바와 같이, 이종 유전자의 프로모터에 의해 구동되는 인간 성장 호르몬-Fc 융합을 위한 발현 카세트를 각각 함유하는 75 ug의 다양한 단일 플라스미드 DNA 구성물을 마우스에 i.v. 투여하였다. 처리 후 1, 8, 22, 29, 43, 50, 84 및 120일에 마우스를 채혈하고 혈청 mAb 단백질 수준을 인간 IgG ELISA 검정으로 분석했다. 도 88에서 각각의 프로모터에 대해 나타낸 막대 그래프는 각각에 대해 1일부터 120일까지 오름차순이다. 평균 hGH-FC 발현 및 SEM이 표시된다.
이 데이터는 DNA 벡터 발현 카세트 내의 DNA 벡터 프로모터 요소의 정체성 및 구성에서 선택된 변화가 유전자 스위치 또는 임의의 다른 추가 변형을 사용하지 않고 단백질 발현 및 생체활성의 크기에 대한 종방향 제어를 허용한다는 것을 보여준다.
실시예 45
11개의 상이한 hGLA DNA 벡터의 테스트
이 실시예는 11개의 상이한 hGLA DNA 벡터를 동시에 테스트하여 시간이 지남에 따라 다양한 혈청 수준을 생성함을 보여준다. 이것은, 예를 들어 hGLA 수준을 1-19 ng/ml 범위로 유지하는 벡터를 확인할 수 있게 했다. 0일에, 각각 1000 nmol의 DOTAP/2.5 mol% 덱사메타손 팔미테이트/SUV 및 DMPC/5 mol% 덱사메타손 팔미테이트/MLV를 구성하는 리포좀으로 i.v. 투여 2시간 전에, 마우스 군을 40 mg/kg 수용성 덱사메타손 i.p.로 전처리했다. 2분 후, 도 89에 나타낸 바와 같이 GLA를 암호화하는 구성물과 함께 75 ug DNA를 i.v. 주입하였다. 마우스는 다음 날 및 그 후 7일 또는 14일마다 채혈하고 hGLA 단백질 생산에 대해 혈청을 평가하였다. 결과는 도 89에 나와 있다.
실시예 46
Fc-변형 단백질 발현
도 89a는 다수의 상이한 FC 변형된 인간 GLA cDNA-암호화된 헤지스 DNA 벡터가 투여 후 1일째에 치료적 혈청 hGLA 수준(>1ng/ml)을 생성함을 보여준다. 그러나 8일에(도 89b), 오직 HyFc, 및 특히 hGLA DNA 벡터를 함유하는 Hy-Fc 1xL만이 GLA 치료 범위 내에 남아있다. 다른 모든 9개의 Fc 변형 DNA 벡터는 8일까지 치료 수준 이하로 떨어졌다. 이러한 결과는 Fc 하이브리드 DNA 벡터의 Fc 부분을 최적화하면 변형된 Fc 함유 DNA 벡터의 혈청 반감기를 크게 향상시킬 수 있음을 보여준다.
도 90은 DNA 벡터를 포함하는 이 hyFc hGLA 함유 DNA 벡터의 사용이 단일 헤지스 DNA 벡터 투여 후 104일에 심장에서 hGLA 조직 수준을 상당히 증가시키기 때문에, 이 Fc 변형이 임상적으로 중요하다는 것을 입증한다. 심장은 GLA 결핍 파브리병 환자에서 가장 손상된 표적 기관 중 하나이다. Fc-변형 GLA가 벡터 주입 후 104일에 심장 조직에서 치료 수준으로 발현될 수 있는 이 실시예에서: 0일에 DOTAP/2.5 mol% 덱사메타손 21-팔미테이트를 포함하는 DOTAP SUV 및 5 mol% 덱사메타손 21-팔미테이트를 포함하는 DMPC MLV 각각 1000 nmol을 함유하는 리포좀으로 i.v. 투여 2시간 전에, 마우스 군을 40 mg/kg 수용성 덱사메타손 IP로 전처리했다. 2분 후, 도 91에 나타낸 바와 같이 점 돌연변이를 갖는 GLA-Fc를 암호화하는 구성물과 함께 75 ug DNA를 i.v. 주입하였다. 마우스를 주입 후 104일에 희생시켰다. 심장을 PBS로 관류한 다음 얼음 위 용해 완충액으로 제거했다. 심장을 초음파 처리하고 라우리(Lowry)에 의해 단백질을 정량화했다. 총 50 ug의 단백질을 웰에 넣고 ELISA로 GLA를 측정했다. 심장 조직 발현 수준은 도 92에 나와 있다.
실시예 47
다양한 Fc 단백질 돌연변이는 발현에 영향을 미친다
이 실시예는 GLA-Fc 발현에 대한 다양한 돌연변이 Fc 영역(도 91에 나타냄)의 발현을 비교한다. 0일에 2.5 mol% 덱사메타손 21-팔미테이트를 포함하는 DOTAP SUV 및 5 mol% 덱사메타손 21-팔미테이트를 포함하는 DMPC MLV 각각 1000 nmol을 함유하는 리포좀으로 i.v. 투여 2시간 전에, 마우스 군을 40 mg/kg 수용성 덱사메타손 IP로 전처리했다. 2분 후, 도 91에 나타낸 바와 같이 점 돌연변이를 갖는 GLA를 암호화하는 구성물과 함께 75 ug DNA를 i.v. 주입하였다. 마우스는 다음날 및 그 후 7일 또는 14일마다 채혈하고 hGLA 단백질 생산에 대해 혈청을 평가했다. 도 91은 부위 지정 돌연변이유발을 통한 HyFC-1xL-hGLA DNA 벡터의 표적화된 단일 또는 여러 DNA 염기 변형이 하이브리드 Fc DNA 벡터 암호화된 단백질 기능의 정확하게 표적화된 단일 염기 변형을 가능하게 한다는 것을 입증한다.
실시예 48
저용량의 덱사메타손 사용
이 실시예는 저용량 덱사메타손 전처리의 사용이 단백질 발현의 지속성을 방해하지 않는다는 것을 설명한다(급성 발현이 증가할 수 있다). 0일에 2.5 mol% 덱사메타손 21-팔미테이트를 포함하는 DOTAP SUV 및 5 mol% 덱사메타손 21-팔미테이트를 포함하는 DMPC MLV 각각 1000 nmol을 함유하는 리포좀으로 i.v. 투여 2시간 전에, 25그램 마우스 군을 지시된 양(도 92에 제시)의 수용성 덱사메타손 IP로 전처리했다. 2분 후, 리툭시맙-바이오시밀러 발현 DNA 플라스미드 75 ug을 i.v.로 투여했다. 다음 날과 8일, 15일 및 22일에 마우스에서 채혈했다. 리툭시맙-바이오시밀러의 혈청 발현은 상업용 ELISA로 결정되었으며 평균 +/- SEM으로 표시되었다. 결과는 도 92에 나타나 있으며, 이는 유리 덱사메타손이 1 내지 40 mg/kg 용량 범위로 사전 투여될 때, 각각 IV DNA 벡터를 이미 높은 수준으로 유지하고, 장기간 단백질 생산을 유지하며, 배경 제어 수준 또는 근접한 배경 제어 수준에서 중요한 독성 마커를 제한하는 능력을 유지함을 보여준다. 또한, 다수의 가장 낮은 유리 덱사메타손 투여량은 i.v. 처리 후 1일에 리툭시맙 혈청 단백질 수준을 통계적으로 유의하게 증가시켰다.
표 7
본 출원에서 언급된 모든 간행물 및 특허는 본 명세서에 참조로 포함된다. 본 발명의 기술된 방법 및 조성물의 다양한 수정 및 변형은 본 발명의 범위 및 정신을 벗어나지 않고 당업자에게 명백할 것이다. 본 발명이 특정한 바람직한 구현양태와 관련하여 설명되었지만, 청구된 발명은 이러한 특정 구현양태에 과도하게 제한되어서는 안 된다는 것을 이해해야 한다. 실제로, 관련 분야의 숙련자에게 명백한 본 발명을 수행하기 위한 설명된 방식의 다양한 변형은 다음 청구범위의 범위 내에 있는 것으로 의도된다.
SEQUENCE LISTING
<110> DNARX
<120> SYSTEMS AND METHODS FOR EXPRESSING BIOMOLECULES IN A SUBJECT
<130> DNARX-38655.601
<150> US 63/083,625
<151> 2020-09-25
<160> 4300
<170> PatentIn version 3.5
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Thr Glu Ala Glu Gln Leu Thr Lys Cys Glu Val Phe Gln
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<213> Saccharomyces cerevisiae
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<221> MISC_FEATURE
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cactatgtgt taattaaaat tatctctaag gcatgtgaac tggctgtctt ggttttcatc 60
tgtacttcat ctgctacctc tgtgacctga aacatattta taattccatt aagctgtgca 120
tatgatagat ttatcatatg tattttcctt aaaggatttt tgtaagaact aattgaattg 180
atacctgtaa agtctttatc acactaccca ataaataata aatctctttg ttcagctctc 240
tgtttctata aatatgtacc agttttattg tttttagtgg tagtgatttt attctctttc 300
tatatatata cacacacatg tgtgcattca taaatatata caatttttat gaataaaaaa 360
ttattagcaa tcaatattga aaaccactga tttttgttta tgtgagcaaa cagcagatta 420
aaaggaattt gaattctcat agctagcagg agtcaatggg aaaaacccat tggagccaag 480
tacactgact caatagggac tttccattgg gttttgccca gtacataagg tcaatagggg 540
gtgagtcaac aggaaagtcc cattggagcc aagtacattg agtcaatagg gactttccaa 600
tgggttttgc ccagtacata aggtcaatgg gaggtaagcc aatgggtttt tcccattact 660
gacatgtata ctgagtcatt agggactttc caatgggttt tgcccagtac ataaggtcaa 720
taggggtgaa tcaacaggaa agtcccattg gagccaagta cactgagtca atagggactt 780
tccattgggt tttgcccagt acaaaaggtc aatagggggt gagtcaatgg gtttttccca 840
ttattggcac atacataagg tcaatagggg tgactagtgg agaagagcat gcttgagggc 900
tgagtgcccc tcagtgggca gagagcacat ggcccacagt ccctgagaag ttggggggag 960
gggtgggcaa ttgaactggt gcctagagaa ggtggggctt gggtaaactg ggaaagtgat 1020
gtggtgtact ggctccacct ttttccccag ggtgggggag aaccatatat aagtgcagta 1080
gtctctgtga acattcaagc ttctgccttc tccctcctgt gagtttggta agtcactgac 1140
tgtctatgcc tgggaaaggg tgggcaggag atggggcagt gcaggaaaag tggcactatg 1200
aaccctgcag ccctagacaa ttgtactaac cttcttctct ttcctctcct gacaggttgg 1260
taaccaagcc accatgggat ggtccctgat cctgctgttt ctggtggctg tggccaccag 1320
agtgctgtct gaagtgcagc tggtggaaag tggtggtggc ctggttcagc ctggtggctc 1380
tctgagactg agctgtgctg cctctggctt cattgtgtcc agcaactaca tgagctgggt 1440
cagacaggcc cctggcaaag gactggaatg ggtgtcagtg atctacagtg gtggcagcac 1500
ctactatgct gactctgtga agggcagatt caccatcagc agacacaaca gcaagaacac 1560
cctgtacctg cagatgaaca gcctgagagc tgaggacact gctgtgtact actgtgccag 1620
agaagcctat ggcatggatg tgtggggcca gggcacaaca gtgactgtgt cctctgccag 1680
cacaaagggc ccctctgtgt ttcctctggc tcccagcagc aagagcacca gtggtggaac 1740
agctgccctg ggctgtctgg tcaaggacta ctttcctgag cctgtgacag tgtcctggaa 1800
ctctggggct ctgacatctg gggtgcacac attccctgca gtgctgcagt cctctggcct 1860
gtacagcctg tcctctgtgg tcacagtgcc tagctctagc ctgggcaccc agacctacat 1920
ctgcaatgtg aaccacaagc ctagcaacac caaggtggac aagaaggctg agcccaagag 1980
ctgtgacaag acccacacct gtcctccatg tcctgctcca gagctgcttg gaggaccatc 2040
agtgtttctg ttccctccaa agcctaagga caccctgatg atcagcagaa cccctgaagt 2100
gacctgtgtg gtggttgatg tgtcccatga ggacccagaa gtgaagttca attggtatgt 2160
ggatggtgtt gaggtgcaca atgccaagac caagcctaga gaggaacagt acaactccac 2220
ctacagagtg gtttctgtgc tgacagtgct ccaccaggac tggctgaatg gcaaagagta 2280
caagtgcaag gtgtccaaca aggccctgcc tgctcctatt gaaaagacca tctccaaggc 2340
caagggccag cctagggaac cccaggttta cacactgcca cctagcaggg atgagctgac 2400
caagaaccag gtgtccctga catgcctggt taagggcttc tacccctctg acattgctgt 2460
ggaatgggag agcaatggcc agccagagaa caactacaag acaacccctc ctgtgctgga 2520
ctctgatggc tcattcttcc tgtactccaa gctgactgtg gacaagtcca gatggcagca 2580
gggcaatgtc tttagctgct ctgtgatgca tgaggccctg cacaaccact acacacagaa 2640
gtccctgtct ctgagccctg gcaagagaaa gagaaggagt ggctctgggg ccaccaactt 2700
cagcctgctg aaacaggctg gggatgttga agagaaccct ggacctatgg cctgggctct 2760
gctgcttctg ggactgctgt ctcactgcac tggctctgtg acagacattg tgatgaccca 2820
gtctccatcc ttcctgagtg cctctgtggg agacagagtg accatcacct gtagagccag 2880
ccagggcatc agctcttacc tggcttggta tcagcaaaag cctggcaagg cccctaagct 2940
gctgatctat gctgcctcca cactgcagtc aggggtgccc tccagatttt ctggctctgg 3000
atctggcact gagttcaccc tgaccatcag ctccctgcag cctgaggact ttgccaccta 3060
ctactgccag cagctgaaca gctaccctcc ttacaccttt ggacagggca ccaagctgga 3120
aatcaaggga acaaagctga cagtcctggg ccagccaaag gctgctcctt ctgtgacact 3180
gttcccacct agctctgagg aactgcaggc taacaaggct acccttgtgt gcctgatctc 3240
tgacttctac ccaggggctg tgactgtggc ttggaaggct gatagcagcc ctgtgaaggc 3300
tggggttgag acaaccacac ctagcaagca gagcaacaac aaatatgctg ccagctccta 3360
cctgagtctg acccctgagc agtggaagtc ccacagatcc tacagctgcc aagtgaccca 3420
tgagggctcc acagtggaaa agacagtggc cccaacagag tgctcctgaa gatctacttc 3480
tggctaataa aagatcagag ctctagtgat ctgtgtgttg gttttttgtg tctgcattct 3540
agcaagtcaa tatgttcacc ccaaaaaagc tgtttgttaa cttgtcaacc tcattctaaa 3600
atgtatatag aagcccaaaa gacaataaca aaaatattct tgtagaacaa aatgggaaag 3660
aatgttccac taaatatcaa gatttagagc aaagcatgag atgtgtgggg atagacagtg 3720
aggctgataa aatagagtag agctcagaaa cagacccatt gatatatgta agtgacctat 3780
gaaaaaaata tggcatttta caatgggaaa atgatggtct ttttcttttt tagaaaaaca 3840
gggaaatata tttatatgta aaaaataaaa gggaacccat atgtcatacc atacacacaa 3900
aaaaattcca gtgaattata agtctaaatg gagaaggcaa aactttaaat cttttagaaa 3960
ataatataga agcatgccat caagacttca gtgtagagaa aaatttctta tgactcaaag 4020
tcctaaccac aaagaaaaga ttgttaatta gattgcatga atattaagac ttatttttaa 4080
aattaaaaaa ccattaagaa aagtcaggcc atagaatgac agaaaatatt tgcaacaccc 4140
cagtaaagag aattgtaata tgcagattat aaaaagaagt cttacaaatc agtaaaaaat 4200
aaaactagac aaaaatttga acagatgaaa gagaaactct aaataatcat tacacatgag 4260
aaactcaatc tcagaaatca gagaactatc attgcatata cactaaatta gagaaatatt 4320
aaaaggctaa gtaacatctg tggcttaatt aatctagctc tagtgatcag cagttcaacc 4380
tgttgatagt atgtactaag ctctcatgtt taatgtacta agctctcatg tttaatgaac 4440
taaaccctca tggctaatgt actaagctct catggctaat gtactaagct ctcatgtttc 4500
atgtactaag ctctcatgtt tgaacaataa aattaatata aatcagcaac ttaaatagcc 4560
tctaaggttt taagttttat aagaaaaaaa agaatatata aggcttttaa aggttttaag 4620
gtttcctagg ttatcctcat atgagctctt agaaaaactc atccagcatc aaatgaaact 4680
gcaatttatt catatcagga ttatcaatac catatttttg aaaaagtctt ttctgtaatg 4740
aaggagaaaa ctcacccagg cagttccata ggatggcaag atcctggtat ctgtctgcaa 4800
ttccaactct tccaacatca atacaaccta ttaatttccc ctcatcaaaa ataaggttat 4860
caagtgagaa atcaccatga gtgaccactg aatctggtga gaatggcaaa agattatgca 4920
tttctttcca gacttgttca acaggccagc catttctctc atcatcaaaa tcactggcat 4980
caaccaaacc attattcatt cttgattggg cctgagccag tctaaatact ctatcagagt 5040
taaaaggaca attacaaaca ggaatggaat gcaatcttct caggaacact gccagggcat 5100
caacaatatt ttcacctgaa tcaggatatt cttccaatac ctggaatgct gttttccctg 5160
ggatggcagt ggtgagtaac catgcatcat caggagttct gataaaatgc ttgatggttg 5220
gaagaggcat aaattcagtc agccagttta gtctgaccat ctcatctgta acatcattgg 5280
caacagaacc tttgccatgt ttcagaaaca actctggggc atctggcttc ccatacaatc 5340
tatagattgt ggcacctgat tgcccaacat tatctctagc ccatttatac ccatataaat 5400
cagcatccat gttggaattt aatcttggcc tggagcaaga ggtttctctt tgaatatggc 5460
tcatacatgt gcacctccta tagtgagttg tattatacta tgcagatata ctatgccaat 5520
gtttaattgt cag 5533
<210> 11
<211> 7318
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic
<400> 11
cactatgtgt taattaaaat tatctctaag gcatgtgaac tggctgtctt ggttttcatc 60
tgtacttcat ctgctacctc tgtgacctga aacatattta taattccatt aagctgtgca 120
tatgatagat ttatcatatg tattttcctt aaaggatttt tgtaagaact aattgaattg 180
atacctgtaa agtctttatc acactaccca ataaataata aatctctttg ttcagctctc 240
tgtttctata aatatgtacc agttttattg tttttagtgg tagtgatttt attctctttc 300
tatatatata cacacacatg tgtgcattca taaatatata caatttttat gaataaaaaa 360
ttattagcaa tcaatattga aaaccactga tttttgttta tgtgagcaaa cagcagatta 420
aaaggaattt gaattctcat agctagcagg agtcaatggg aaaaacccat tggagccaag 480
tacactgact caatagggac tttccattgg gttttgccca gtacataagg tcaatagggg 540
gtgagtcaac aggaaagtcc cattggagcc aagtacattg agtcaatagg gactttccaa 600
tgggttttgc ccagtacata aggtcaatgg gaggtaagcc aatgggtttt tcccattact 660
gacatgtata ctgagtcatt agggactttc caatgggttt tgcccagtac ataaggtcaa 720
taggggtgaa tcaacaggaa agtcccattg gagccaagta cactgagtca atagggactt 780
tccattgggt tttgcccagt acaaaaggtc aatagggggt gagtcaatgg gtttttccca 840
ttattggcac atacataagg tcaatagggg tgactagtgg agaagagcat gcttgagggc 900
tgagtgcccc tcagtgggca gagagcacat ggcccacagt ccctgagaag ttggggggag 960
gggtgggcaa ttgaactggt gcctagagaa ggtggggctt gggtaaactg ggaaagtgat 1020
gtggtgtact ggctccacct ttttccccag ggtgggggag aaccatatat aagtgcagta 1080
gtctctgtga acattcaagc ttctgccttc tccctcctgt gagtttggta agtcactgac 1140
tgtctatgcc tgggaaaggg tgggcaggag atggggcagt gcaggaaaag tggcactatg 1200
aaccctgcag ccctagacaa ttgtactaac cttcttctct ttcctctcct gacaggttgg 1260
taaccaagcc accatgggat ggtccctgat cctgctgttt ctggtggctg tggccaccag 1320
agtgctgtct gaagtgcagc tggtggaaag tggtggtggc ctggttcagc ctggtggctc 1380
tctgagactg agctgtgctg cctctggctt cattgtgtcc agcaactaca tgagctgggt 1440
cagacaggcc cctggcaaag gactggaatg ggtgtcagtg atctacagtg gtggcagcac 1500
ctactatgct gactctgtga agggcagatt caccatcagc agacacaaca gcaagaacac 1560
cctgtacctg cagatgaaca gcctgagagc tgaggacact gctgtgtact actgtgccag 1620
agaagcctat ggcatggatg tgtggggcca gggcacaaca gtgactgtgt cctctgccag 1680
cacaaagggc ccctctgtgt ttcctctggc tcccagcagc aagagcacca gtggtggaac 1740
agctgccctg ggctgtctgg tcaaggacta ctttcctgag cctgtgacag tgtcctggaa 1800
ctctggggct ctgacatctg gggtgcacac attccctgca gtgctgcagt cctctggcct 1860
gtacagcctg tcctctgtgg tcacagtgcc tagctctagc ctgggcaccc agacctacat 1920
ctgcaatgtg aaccacaagc ctagcaacac caaggtggac aagaaggctg agcccaagag 1980
ctgtgacaag acccacacct gtcctccatg tcctgctcca gagctgcttg gaggaccatc 2040
agtgtttctg ttccctccaa agcctaagga caccctgatg atcagcagaa cccctgaagt 2100
gacctgtgtg gtggttgatg tgtcccatga ggacccagaa gtgaagttca attggtatgt 2160
ggatggtgtt gaggtgcaca atgccaagac caagcctaga gaggaacagt acaactccac 2220
ctacagagtg gtttctgtgc tgacagtgct ccaccaggac tggctgaatg gcaaagagta 2280
caagtgcaag gtgtccaaca aggccctgcc tgctcctatt gaaaagacca tctccaaggc 2340
caagggccag cctagggaac cccaggttta cacactgcca cctagcaggg atgagctgac 2400
caagaaccag gtgtccctga catgcctggt taagggcttc tacccctctg acattgctgt 2460
ggaatgggag agcaatggcc agccagagaa caactacaag acaacccctc ctgtgctgga 2520
ctctgatggc tcattcttcc tgtactccaa gctgactgtg gacaagtcca gatggcagca 2580
gggcaatgtc tttagctgct ctgtgatgca tgaggccctg cacaaccact acacacagaa 2640
gtccctgtct ctgagccctg gcaagtgaag atctacttct ggctaataaa agatcagagc 2700
tctagtgatc tgtgtgttgg ttttttgtgt ctgcattcta gcagagcccc actgtgttca 2760
tcttacagat ggaaatactg acattcagag gagttagtta acttgcctag gtgattcagc 2820
taataagtgc aagaaagatt tcaatccaag gtgatttgat tctgaagcct gtgctaatca 2880
cattacacca agctacaact tcatttataa ataataagtc agctttcaag ggcctttcag 2940
gtgtcctgca cttctacaag ctgtgccatt tagtgaacac aaaatgagcc ttctgatgaa 3000
gtagtctttt cattatttca gatattagaa cactaaaatt cttagctgcc agctgattga 3060
aggctgggac aaaattcaaa catgcatcta caacaatata tatctcaatg ttagtctcca 3120
aattctattg acttcaactc aagagaatat aaagagctag tctttataca ctctttaagg 3180
tatgatatca tctggaaagt aacaaaattg atgcaaattt gaatgaactt tatcatggtg 3240
tatttacaca atgtgtttct tctccctgca atgtatttct ttctctaatt ccttccattt 3300
gatctttcat acacaatctg gttctgatgt atgttttttg gatgcacttt tcaactccaa 3360
aagacagagc tagttacttt cttcctggtg ctccaagcac tgtatttgta tctgtattca 3420
agccctttgc aatattgtac tggatcatta tttcacctct aggatggctt ccccaggcaa 3480
cttgtgttca cccagagact acattttgta tcttgttgac ctttgaactt ccaccagtgt 3540
ctaaaaataa tatgtatgca aaattacttg ctatgagaat gtataattaa acaatataaa 3600
aaggagaagc aaggagagaa acacaggtgt gtatttgtgt ttgtgtgctt aaaaggcagt 3660
gtggaaaagg aagaaatgcc atttatagtg aggagacaaa gttatattac ctcttatctg 3720
gcttttaagg agattttgct gagctaaaaa tcctatattc atagaaaagc cttacctgag 3780
ttgccaatac ctcaattcag tctagctgtt acataactta tggtaaatgg cctgcctggc 3840
tgactgccca atgacccctg cccaatgatg tcaataatga tgtatgttcc catgtaatgc 3900
caatagggac tttccattga tgtcaatggg tggagtattt atggtaactg cccacttggc 3960
agtacatcaa gtgtatcata tgccaagtat gccccctatt gatgtcaatg atggtaaatg 4020
gcctgcctgg cattatgccc agtacatgac cttatgggac tttcctactt ggcagtacat 4080
ctatgtatta gtcattgcta ttaccatgga ttagtggaga agagcatgct tgagggctga 4140
gtgcccctca gtgggcagag agcacatggc ccacagtccc tgagaagttg gggggagggg 4200
tgggcaattg aactggtgcc tagagaaggt ggggcttggg taaactggga aagtgatgtg 4260
gtgtactggc tccacctttt tccccagggt gggggagaac catatataag tgcagtagtc 4320
tctgtgaaca ttcaagcttc tgccttctcc ctcctgtgag tttggatgca cctactagat 4380
atcttggtaa gtcactgact gtctatgcct gggaaagggt gggcaggagg tggggcagtg 4440
caggaaaagt ggcactgtga accctgcagc cctagacaat tgtactaacc ttcttctctt 4500
tcctctcctg acaggttggt aaccaagcca ccatggcctg ggctctgctg cttctgggac 4560
tgctgtctca ctgcactggc tctgtgacag acattgtgat gacccagtct ccatccttcc 4620
tgagtgcctc tgtgggagac agagtgacca tcacctgtag agccagccag ggcatcagct 4680
cttacctggc ttggtatcag caaaagcctg gcaaggcccc taagctgctg atctatgctg 4740
cctccacact gcagtcaggg gtgccctcca gattttctgg ctctggatct ggcactgagt 4800
tcaccctgac catcagctcc ctgcagcctg aggactttgc cacctactac tgccagcagc 4860
tgaacagcta ccctccttac acctttggac agggcaccaa gctggaaatc aagggaacaa 4920
agctgacagt cctgggccag ccaaaggctg ctccttctgt gacactgttc ccacctagct 4980
ctgaggaact gcaggctaac aaggctaccc ttgtgtgcct gatctctgac ttctacccag 5040
gggctgtgac tgtggcttgg aaggctgata gcagccctgt gaaggctggg gttgagacaa 5100
ccacacctag caagcagagc aacaacaaat atgctgccag ctcctacctg agtctgaccc 5160
ctgagcagtg gaagtcccac agatcctaca gctgccaagt gacccatgag ggctccacag 5220
tggaaaagac agtggcccca acagagtgct cctgaagatc tacttctggc taataaaaga 5280
tcagagctct agtgatctgt gtgttggttt tttgtgtctg cattctagca gtcaatatgt 5340
tcaccccaaa aaagctgttt gttaacttgt caacctcatt ctaaaatgta tatagaagcc 5400
caaaagacaa taacaaaaat attcttgtag aacaaaatgg gaaagaatgt tccactaaat 5460
atcaagattt agagcaaagc atgagatgtg tggggataga cagtgaggct gataaaatag 5520
agtagagctc agaaacagac ccattgatat atgtaagtga cctatgaaaa aaatatggca 5580
ttttacaatg ggaaaatgat ggtctttttc ttttttagaa aaacagggaa atatatttat 5640
atgtaaaaaa taaaagggaa cccatatgtc ataccataca cacaaaaaaa ttccagtgaa 5700
ttataagtct aaatggagaa ggcaaaactt taaatctttt agaaaataat atagaagcat 5760
gccatcaaga cttcagtgta gagaaaaatt tcttatgact caaagtccta accacaaaga 5820
aaagattgtt aattagattg catgaatatt aagacttatt tttaaaatta aaaaaccatt 5880
aagaaaagtc aggccataga atgacagaaa atatttgcaa caccccagta aagagaattg 5940
taatatgcag attataaaaa gaagtcttac aaatcagtaa aaaataaaac tagacaaaaa 6000
tttgaacaga tgaaagagaa actctaaata atcattacac atgagaaact caatctcaga 6060
aatcagagaa ctatcattgc atatacacta aattagagaa atattaaaag gctaagtaac 6120
atctgtggct taattaatct agctctagtg atcagcagtt caacctgttg atagtatgta 6180
ctaagctctc atgtttaatg tactaagctc tcatgtttaa tgaactaaac cctcatggct 6240
aatgtactaa gctctcatgg ctaatgtact aagctctcat gtttcatgta ctaagctctc 6300
atgtttgaac aataaaatta atataaatca gcaacttaaa tagcctctaa ggttttaagt 6360
tttataagaa aaaaaagaat atataaggct tttaaaggtt ttaaggtttc ctaggttatc 6420
ctcatatgag ctcttagaaa aactcatcca gcatcaaatg aaactgcaat ttattcatat 6480
caggattatc aataccatat ttttgaaaaa gtcttttctg taatgaagga gaaaactcac 6540
ccaggcagtt ccataggatg gcaagatcct ggtatctgtc tgcaattcca actcttccaa 6600
catcaataca acctattaat ttcccctcat caaaaataag gttatcaagt gagaaatcac 6660
catgagtgac cactgaatct ggtgagaatg gcaaaagatt atgcatttct ttccagactt 6720
gttcaacagg ccagccattt ctctcatcat caaaatcact ggcatcaacc aaaccattat 6780
tcattcttga ttgggcctga gccagtctaa atactctatc agagttaaaa ggacaattac 6840
aaacaggaat ggaatgcaat cttctcagga acactgccag ggcatcaaca atattttcac 6900
ctgaatcagg atattcttcc aatacctgga atgctgtttt ccctgggatg gcagtggtga 6960
gtaaccatgc atcatcagga gttctgataa aatgcttgat ggttggaaga ggcataaatt 7020
cagtcagcca gtttagtctg accatctcat ctgtaacatc attggcaaca gaacctttgc 7080
catgtttcag aaacaactct ggggcatctg gcttcccata caatctatag attgtggcac 7140
ctgattgccc aacattatct ctagcccatt tatacccata taaatcagca tccatgttgg 7200
aatttaatct tggcctggag caagaggttt ctctttgaat atggctcata catgtgcacc 7260
tcctatagtg agttgtatta tactatgcag atatactatg ccaatgttta attgtcag 7318
<210> 12
<211> 5524
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic
<400> 12
cactatgtgt taattaaaat tatctctaag gcatgtgaac tggctgtctt ggttttcatc 60
tgtacttcat ctgctacctc tgtgacctga aacatattta taattccatt aagctgtgca 120
tatgatagat ttatcatatg tattttcctt aaaggatttt tgtaagaact aattgaattg 180
atacctgtaa agtctttatc acactaccca ataaataata aatctctttg ttcagctctc 240
tgtttctata aatatgtacc agttttattg tttttagtgg tagtgatttt attctctttc 300
tatatatata cacacacatg tgtgcattca taaatatata caatttttat gaataaaaaa 360
ttattagcaa tcaatattga aaaccactga tttttgttta tgtgagcaaa cagcagatta 420
aaaggaattt gaattctcat agctagcagg agtcaatggg aaaaacccat tggagccaag 480
tacactgact caatagggac tttccattgg gttttgccca gtacataagg tcaatagggg 540
gtgagtcaac aggaaagtcc cattggagcc aagtacattg agtcaatagg gactttccaa 600
tgggttttgc ccagtacata aggtcaatgg gaggtaagcc aatgggtttt tcccattact 660
gacatgtata ctgagtcatt agggactttc caatgggttt tgcccagtac ataaggtcaa 720
taggggtgaa tcaacaggaa agtcccattg gagccaagta cactgagtca atagggactt 780
tccattgggt tttgcccagt acaaaaggtc aatagggggt gagtcaatgg gtttttccca 840
ttattggcac atacataagg tcaatagggg tgactagtgg agaagagcat gcttgagggc 900
tgagtgcccc tcagtgggca gagagcacat ggcccacagt ccctgagaag ttggggggag 960
gggtgggcaa ttgaactggt gcctagagaa ggtggggctt gggtaaactg ggaaagtgat 1020
gtggtgtact ggctccacct ttttccccag ggtgggggag aaccatatat aagtgcagta 1080
gtctctgtga acattcaagc ttctgccttc tccctcctgt gagtttggta agtcactgac 1140
tgtctatgcc tgggaaaggg tgggcaggag atggggcagt gcaggaaaag tggcactatg 1200
aaccctgcag ccctagacaa ttgtactaac cttcttctct ttcctctcct gacaggttgg 1260
taaccaagcc accatgggat ggtccctgat cctgctgttt ctggtggctg tggccaccag 1320
agtgctgtct gaagtgcagc tggtggaaag tggtggtggc ctggttcagc ctggtggctc 1380
tctgagactg agctgtgctg cctctggctt cattgtgtcc agcaactaca tgagctgggt 1440
cagacaggcc cctggcaaag gactggaatg ggtgtcagtg atctacagtg gtggcagcac 1500
ctactatgct gactctgtga agggcagatt caccatcagc agacacaaca gcaagaacac 1560
cctgtacctg cagatgaaca gcctgagagc tgaggacact gctgtgtact actgtgccag 1620
agaagcctat ggcatggatg tgtggggcca gggcacaaca gtgactgtgt cctctgccag 1680
cacaaagggc ccctctgtgt ttcctctggc tcccagcagc aagagcacca gtggtggaac 1740
agctgccctg ggctgtctgg tcaaggacta ctttcctgag cctgtgacag tgtcctggaa 1800
ctctggggct ctgacatctg gggtgcacac attccctgca gtgctgcagt cctctggcct 1860
gtacagcctg tcctctgtgg tcacagtgcc tagctctagc ctgggcaccc agacctacat 1920
ctgcaatgtg aaccacaagc ctagcaacac caaggtggac aagaaggctg agcccaagag 1980
ctgtgacaag acccacacct gtcctccatg tcctgctcca gagctgcttg gaggaccatc 2040
agtgtttctg ttccctccaa agcctaagga caccctgatg atcagcagaa cccctgaagt 2100
gacctgtgtg gtggttgatg tgtcccatga ggacccagaa gtgaagttca attggtatgt 2160
ggatggtgtt gaggtgcaca atgccaagac caagcctaga gaggaacagt acaactccac 2220
ctacagagtg gtttctgtgc tgacagtgct ccaccaggac tggctgaatg gcaaagagta 2280
caagtgcaag gtgtccaaca aggccctgcc tgctcctatt gaaaagacca tctccaaggc 2340
caagggccag cctagggaac cccaggttta cacactgcca cctagcaggg atgagctgac 2400
caagaaccag gtgtccctga catgcctggt taagggcttc tacccctctg acattgctgt 2460
ggaatgggag agcaatggcc agccagagaa caactacaag acaacccctc ctgtgctgga 2520
ctctgatggc tcattcttcc tgtactccaa gctgactgtg gacaagtcca gatggcagca 2580
gggcaatgtc tttagctgct ctgtgatgca tgaggccctg cacaaccact acacacagaa 2640
gtccctgtct ctgagccctg gcaagagaaa gagaaggagt ggctctgggg ccaccaactt 2700
cagcctgctg aaacaggctg gggatgttga agagaaccct ggacctatgg acttccaggt 2760
gcagatcatc agctttctgc ttatctctgc cagtgtgatc atgagcaggg gagacattgt 2820
gatgacccag tctccatcct tcctgagtgc ctctgtggga gacagagtga ccatcacctg 2880
tagagccagc cagggcatca gctcttacct ggcttggtat cagcaaaagc ctggcaaggc 2940
ccctaagctg ctgatctatg ctgcctccac actgcagtca ggggtgccct ccagattttc 3000
tggctctgga tctggcactg agttcaccct gaccatcagc tccctgcagc ctgaggactt 3060
tgccacctac tactgccagc agctgaacag ctaccctcct tacacctttg gacagggcac 3120
caagctggaa atcaagagga cagtggctgc tccttctgtg ttcatcttcc caccatcaga 3180
tgaacagctg aagagtggca cagcctctgt tgtgtgcctg ctcaacaact tctaccctag 3240
agaagccaag gtgcagtgga aagtggacaa tgccctccag tctggcaaca gccaagaatc 3300
tgtgactgag caggactcca aggacagcac atacagcctg agcagcacac tgaccctgag 3360
caaggctgac tatgagaagc acaaagtcta tgcctgtgaa gtgacacacc agggcctgtc 3420
tagcccagtg accaagtcct tcaacagggg agagtgttga agatctactt ctggctaata 3480
aaagatcaga gctctagtga tctgtgtgtt ggttttttgt gtctgcattc tagcaagtca 3540
atatgttcac cccaaaaaag ctgtttgtta acttgtcaac ctcattctaa aatgtatata 3600
gaagcccaaa agacaataac aaaaatattc ttgtagaaca aaatgggaaa gaatgttcca 3660
ctaaatatca agatttagag caaagcatga gatgtgtggg gatagacagt gaggctgata 3720
aaatagagta gagctcagaa acagacccat tgatatatgt aagtgaccta tgaaaaaaat 3780
atggcatttt acaatgggaa aatgatggtc tttttctttt ttagaaaaac agggaaatat 3840
atttatatgt aaaaaataaa agggaaccca tatgtcatac catacacaca aaaaaattcc 3900
agtgaattat aagtctaaat ggagaaggca aaactttaaa tcttttagaa aataatatag 3960
aagcatgcca tcaagacttc agtgtagaga aaaatttctt atgactcaaa gtcctaacca 4020
caaagaaaag attgttaatt agattgcatg aatattaaga cttattttta aaattaaaaa 4080
accattaaga aaagtcaggc catagaatga cagaaaatat ttgcaacacc ccagtaaaga 4140
gaattgtaat atgcagatta taaaaagaag tcttacaaat cagtaaaaaa taaaactaga 4200
caaaaatttg aacagatgaa agagaaactc taaataatca ttacacatga gaaactcaat 4260
ctcagaaatc agagaactat cattgcatat acactaaatt agagaaatat taaaaggcta 4320
agtaacatct gtggcttaat taatctagct ctagtgatca gcagttcaac ctgttgatag 4380
tatgtactaa gctctcatgt ttaatgtact aagctctcat gtttaatgaa ctaaaccctc 4440
atggctaatg tactaagctc tcatggctaa tgtactaagc tctcatgttt catgtactaa 4500
gctctcatgt ttgaacaata aaattaatat aaatcagcaa cttaaatagc ctctaaggtt 4560
ttaagtttta taagaaaaaa aagaatatat aaggctttta aaggttttaa ggtttcctag 4620
gttatcctca tatgagctct tagaaaaact catccagcat caaatgaaac tgcaatttat 4680
tcatatcagg attatcaata ccatattttt gaaaaagtct tttctgtaat gaaggagaaa 4740
actcacccag gcagttccat aggatggcaa gatcctggta tctgtctgca attccaactc 4800
ttccaacatc aatacaacct attaatttcc cctcatcaaa aataaggtta tcaagtgaga 4860
aatcaccatg agtgaccact gaatctggtg agaatggcaa aagattatgc atttctttcc 4920
agacttgttc aacaggccag ccatttctct catcatcaaa atcactggca tcaaccaaac 4980
cattattcat tcttgattgg gcctgagcca gtctaaatac tctatcagag ttaaaaggac 5040
aattacaaac aggaatggaa tgcaatcttc tcaggaacac tgccagggca tcaacaatat 5100
tttcacctga atcaggatat tcttccaata cctggaatgc tgttttccct gggatggcag 5160
tggtgagtaa ccatgcatca tcaggagttc tgataaaatg cttgatggtt ggaagaggca 5220
taaattcagt cagccagttt agtctgacca tctcatctgt aacatcattg gcaacagaac 5280
ctttgccatg tttcagaaac aactctgggg catctggctt cccatacaat ctatagattg 5340
tggcacctga ttgcccaaca ttatctctag cccatttata cccatataaa tcagcatcca 5400
tgttggaatt taatcttggc ctggagcaag aggtttctct ttgaatatgg ctcatacatg 5460
tgcacctcct atagtgagtt gtattatact atgcagatat actatgccaa tgtttaattg 5520
tcag 5524
<210> 13
<211> 5575
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic
<400> 13
cactatgtgt taattaaaat tatctctaag gcatgtgaac tggctgtctt ggttttcatc 60
tgtacttcat ctgctacctc tgtgacctga aacatattta taattccatt aagctgtgca 120
tatgatagat ttatcatatg tattttcctt aaaggatttt tgtaagaact aattgaattg 180
atacctgtaa agtctttatc acactaccca ataaataata aatctctttg ttcagctctc 240
tgtttctata aatatgtacc agttttattg tttttagtgg tagtgatttt attctctttc 300
tatatatata cacacacatg tgtgcattca taaatatata caatttttat gaataaaaaa 360
ttattagcaa tcaatattga aaaccactga tttttgttta tgtgagcaaa cagcagatta 420
aaaggaattt gaattctcat agctagcagg agtcaatggg aaaaacccat tggagccaag 480
tacactgact caatagggac tttccattgg gttttgccca gtacataagg tcaatagggg 540
gtgagtcaac aggaaagtcc cattggagcc aagtacattg agtcaatagg gactttccaa 600
tgggttttgc ccagtacata aggtcaatgg gaggtaagcc aatgggtttt tcccattact 660
gacatgtata ctgagtcatt agggactttc caatgggttt tgcccagtac ataaggtcaa 720
taggggtgaa tcaacaggaa agtcccattg gagccaagta cactgagtca atagggactt 780
tccattgggt tttgcccagt acaaaaggtc aatagggggt gagtcaatgg gtttttccca 840
ttattggcac atacataagg tcaatagggg tgactagtgg agaagagcat gcttgagggc 900
tgagtgcccc tcagtgggca gagagcacat ggcccacagt ccctgagaag ttggggggag 960
gggtgggcaa ttgaactggt gcctagagaa ggtggggctt gggtaaactg ggaaagtgat 1020
gtggtgtact ggctccacct ttttccccag ggtgggggag aaccatatat aagtgcagta 1080
gtctctgtga acattcaagc ttctgccttc tccctcctgt gagtttggta agtcactgac 1140
tgtctatgcc tgggaaaggg tgggcaggag atggggcagt gcaggaaaag tggcactatg 1200
aaccctgcag ccctagacaa ttgtactaac cttcttctct ttcctctcct gacaggttgg 1260
taaccaagcc accatgggat ggtccctgat cctgctgttt ctggtggctg tggccaccag 1320
agtgctgtct caggttcagc tggtgcagtc tggggctgaa gtgaagaaac ctggggcctc 1380
tgtgaaggtg tcctgcaagg cttctggcta cacattcaca ggctactaca tgcactgggt 1440
cagacaggcc cctggacagg gacttgagtg gatgggcaga atcaacccca acagtggtgg 1500
caccaactat gcccagaaat tccagggcag agtgaccatg accagagaca ccagcatcag 1560
cacagcctac atggaactga gcaggcttag gagtgatgac actgctgtgt actactgtgc 1620
cagagtgccc tactgcagca gcacctcttg tcacagagac tggtactttg acctgtgggg 1680
cagaggcacc ctggtcacag ttagctctgc cagcacaaag ggcccctctg tgtttcctct 1740
ggctcccagc agcaagagca ccagtggtgg aacagctgcc ctgggctgtc tggtcaagga 1800
ctactttcct gagcctgtga cagtgtcctg gaactctggg gctctgacat ctggggtgca 1860
cacattccct gctgtgctgc agtcctctgg cctgtacagc ctgtcctctg tggtcactgt 1920
gcctagctct agcctgggca cccagaccta catctgcaat gtgaaccaca agcctagcaa 1980
caccaaggtg gacaagaagg ctgagcccaa gagctgtgat aagacccaca cctgtcctcc 2040
atgtcctgct ccagagctgc ttggaggacc atcagtgttt ctgttccctc caaagcctaa 2100
ggacaccctg atgatcagca gaacccctga agtgacctgt gtggtggtgg atgtgtccca 2160
tgaggaccca gaagtgaagt tcaattggta tgtggatggt gttgaggtgc acaatgccaa 2220
gaccaagcct agagaggaac agtacaacag cacctacaga gtggtgtctg tgctgacagt 2280
gctgcaccag gactggctga atggcaaaga gtacaagtgc aaggtgtcca acaaggccct 2340
gcctgctcct attgaaaaga ccatcagcaa ggccaagggc cagcctaggg aaccccaagt 2400
gtataccctg cctcctagca gagatgagct gaccaagaac caggtgtccc tgacatgcct 2460
ggttaagggc ttctacccct ctgacattgc tgtggaatgg gagagcaatg gccagcctga 2520
gaacaactac aagaccacac ctcctgtgct ggactctgat ggctcattct tcctgtactc 2580
caagctgact gtggacaagt ccagatggca gcaaggcaat gtgttcagct gctctgtgat 2640
gcatgaggcc ctgcacaacc actacacaca gaagtctctg tctctgagcc ctggcaagag 2700
aaagagaagg agtggctctg gggccaccaa cttcagcctg ctgaaacagg ctggggatgt 2760
tgaagagaac cctggaccta tggacttcca ggtgcagatc atcagctttc tgcttatctc 2820
tgccagtgtg atcatgagca ggggagacat ccagatgaca cagagccctc tgagcctgcc 2880
agtgacacct ggggaacctg ccagcatctc ttgcagaagc tctcagagcc tcctggattc 2940
tgatgatggc aacacctacc tggactggta tctgcagaag cctggccagt ctcctcagct 3000
gctgatctac accctgagct acagagccag tggggtgcca gacagattct ctggctctgg 3060
atctggcact gacttcacac tgaagattag cagagtggaa gctgaggatg tgggagtcta 3120
ctactgtatg cagaggattg agttccctct gacttttggt ggtggtacaa aggtggaaat 3180
caagaggaca gtggctgctc cttctgtgtt catcttccca ccatctgatg agcagctcaa 3240
gagtggcaca gcctctgttg tgtgtctgct gaacaacttc taccctaggg aagccaaggt 3300
gcagtggaaa gtggacaatg ccctccagtc tggcaacagc caagagagtg tgacagaaca 3360
ggacagcaag gactccacct acagcctgag cagcaccctg acactgagca aggctgacta 3420
tgagaagcac aaagtctatg cctgtgaagt gacacaccag ggactgagca gccctgtgac 3480
caagagcttc aacaggggag agtgcagctg aagatctact tctggctaat aaaagatcag 3540
agctctagtg atctgtgtgt tggttttttg tgtctgcatt ctagcaagtc aatatgttca 3600
ccccaaaaaa gctgtttgtt aacttgtcaa cctcattcta aaatgtatat agaagcccaa 3660
aagacaataa caaaaatatt cttgtagaac aaaatgggaa agaatgttcc actaaatatc 3720
aagatttaga gcaaagcatg agatgtgtgg ggatagacag tgaggctgat aaaatagagt 3780
agagctcaga aacagaccca ttgatatatg taagtgacct atgaaaaaaa tatggcattt 3840
tacaatggga aaatgatggt ctttttcttt tttagaaaaa cagggaaata tatttatatg 3900
taaaaaataa aagggaaccc atatgtcata ccatacacac aaaaaaattc cagtgaatta 3960
taagtctaaa tggagaaggc aaaactttaa atcttttaga aaataatata gaagcatgcc 4020
atcaagactt cagtgtagag aaaaatttct tatgactcaa agtcctaacc acaaagaaaa 4080
gattgttaat tagattgcat gaatattaag acttattttt aaaattaaaa aaccattaag 4140
aaaagtcagg ccatagaatg acagaaaata tttgcaacac cccagtaaag agaattgtaa 4200
tatgcagatt ataaaaagaa gtcttacaaa tcagtaaaaa ataaaactag acaaaaattt 4260
gaacagatga aagagaaact ctaaataatc attacacatg agaaactcaa tctcagaaat 4320
cagagaacta tcattgcata tacactaaat tagagaaata ttaaaaggct aagtaacatc 4380
tgtggcttaa ttaatctagc tctagtgatc agcagttcaa cctgttgata gtatgtacta 4440
agctctcatg tttaatgtac taagctctca tgtttaatga actaaaccct catggctaat 4500
gtactaagct ctcatggcta atgtactaag ctctcatgtt tcatgtacta agctctcatg 4560
tttgaacaat aaaattaata taaatcagca acttaaatag cctctaaggt tttaagtttt 4620
ataagaaaaa aaagaatata taaggctttt aaaggtttta aggtttccta ggttatcctc 4680
atatgagctc ttagaaaaac tcatccagca tcaaatgaaa ctgcaattta ttcatatcag 4740
gattatcaat accatatttt tgaaaaagtc ttttctgtaa tgaaggagaa aactcaccca 4800
ggcagttcca taggatggca agatcctggt atctgtctgc aattccaact cttccaacat 4860
caatacaacc tattaatttc ccctcatcaa aaataaggtt atcaagtgag aaatcaccat 4920
gagtgaccac tgaatctggt gagaatggca aaagattatg catttctttc cagacttgtt 4980
caacaggcca gccatttctc tcatcatcaa aatcactggc atcaaccaaa ccattattca 5040
ttcttgattg ggcctgagcc agtctaaata ctctatcaga gttaaaagga caattacaaa 5100
caggaatgga atgcaatctt ctcaggaaca ctgccagggc atcaacaata ttttcacctg 5160
aatcaggata ttcttccaat acctggaatg ctgttttccc tgggatggca gtggtgagta 5220
accatgcatc atcaggagtt ctgataaaat gcttgatggt tggaagaggc ataaattcag 5280
tcagccagtt tagtctgacc atctcatctg taacatcatt ggcaacagaa cctttgccat 5340
gtttcagaaa caactctggg gcatctggct tcccatacaa tctatagatt gtggcacctg 5400
attgcccaac attatctcta gcccatttat acccatataa atcagcatcc atgttggaat 5460
ttaatcttgg cctggagcaa gaggtttctc tttgaatatg gctcatacat gtgcacctcc 5520
tatagtgagt tgtattatac tatgcagata tactatgcca atgtttaatt gtcag 5575
<210> 14
<211> 9777
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic
<400> 14
cactatgtgt taattaaaat tatctctaag gcatgtgaac tggctgtctt ggttttcatc 60
tgtacttcat ctgctacctc tgtgacctga aacatattta taattccatt aagctgtgca 120
tatgatagat ttatcatatg tattttcctt aaaggatttt tgtaagaact aattgaattg 180
atacctgtaa agtctttatc acactaccca ataaataata aatctctttg ttcagctctc 240
tgtttctata aatatgtacc agttttattg tttttagtgg tagtgatttt attctctttc 300
tatatatata cacacacatg tgtgcattca taaatatata caatttttat gaataaaaaa 360
ttattagcaa tcaatattga aaaccactga tttttgttta tgtgagcaaa cagcagatta 420
aaaggaattt gaattctcat agctagcagg agtcaatggg aaaaacccat tggagccaag 480
tacactgact caatagggac tttccattgg gttttgccca gtacataagg tcaatagggg 540
gtgagtcaac aggaaagtcc cattggagcc aagtacattg agtcaatagg gactttccaa 600
tgggttttgc ccagtacata aggtcaatgg gaggtaagcc aatgggtttt tcccattact 660
gacatgtata ctgagtcatt agggactttc caatgggttt tgcccagtac ataaggtcaa 720
taggggtgaa tcaacaggaa agtcccattg gagccaagta cactgagtca atagggactt 780
tccattgggt tttgcccagt acaaaaggtc aatagggggt gagtcaatgg gtttttccca 840
ttattggcac atacataagg tcaatagggg tgactagtgg agaagagcat gcttgagggc 900
tgagtgcccc tcagtgggca gagagcacat ggcccacagt ccctgagaag ttggggggag 960
gggtgggcaa ttgaactggt gcctagagaa ggtggggctt gggtaaactg ggaaagtgat 1020
gtggtgtact ggctccacct ttttccccag ggtgggggag aaccatatat aagtgcagta 1080
gtctctgtga acattcaagc ttctgccttc tccctcctgt gagtttggta agtcactgac 1140
tgtctatgcc tgggaaaggg tgggcaggag atggggcagt gcaggaaaag tggcactatg 1200
aaccctgcag ccctagacaa ttgtactaac cttcttctct ttcctctcct gacaggttgg 1260
taaccaagcc accatgggat ggtccctgat cctgctgttt ctggtggctg tggccaccag 1320
agtgctgtct caggttcagc tggtgcagtc tggggctgaa gtgaagaaac ctggggcctc 1380
tgtgaaggtg tcctgcaagg cttctggcta cacattcaca ggctactaca tgcactgggt 1440
cagacaggcc cctggacagg gacttgagtg gatgggcaga atcaacccca acagtggtgg 1500
caccaactat gcccagaaat tccagggcag agtgaccatg accagagaca ccagcatcag 1560
cacagcctac atggaactga gcaggcttag gagtgatgac actgctgtgt actactgtgc 1620
cagagtgccc tactgcagca gcacctcttg tcacagagac tggtactttg acctgtgggg 1680
cagaggcacc ctggtcacag ttagctctgc cagcacaaag ggcccctctg tgtttcctct 1740
ggctcccagc agcaagagca ccagtggtgg aacagctgcc ctgggctgtc tggtcaagga 1800
ctactttcct gagcctgtga cagtgtcctg gaactctggg gctctgacat ctggggtgca 1860
cacattccct gctgtgctgc agtcctctgg cctgtacagc ctgtcctctg tggtcactgt 1920
gcctagctct agcctgggca cccagaccta catctgcaat gtgaaccaca agcctagcaa 1980
caccaaggtg gacaagaagg ctgagcccaa gagctgtgat aagacccaca cctgtcctcc 2040
atgtcctgct ccagagctgc ttggaggacc atcagtgttt ctgttccctc caaagcctaa 2100
ggacaccctg atgatcagca gaacccctga agtgacctgt gtggtggtgg atgtgtccca 2160
tgaggaccca gaagtgaagt tcaattggta tgtggatggt gttgaggtgc acaatgccaa 2220
gaccaagcct agagaggaac agtacaacag cacctacaga gtggtgtctg tgctgacagt 2280
gctgcaccag gactggctga atggcaaaga gtacaagtgc aaggtgtcca acaaggccct 2340
gcctgctcct attgaaaaga ccatcagcaa ggccaagggc cagcctaggg aaccccaagt 2400
gtataccctg cctcctagca gagatgagct gaccaagaac caggtgtccc tgacatgcct 2460
ggttaagggc ttctacccct ctgacattgc tgtggaatgg gagagcaatg gccagcctga 2520
gaacaactac aagaccacac ctcctgtgct ggactctgat ggctcattct tcctgtactc 2580
caagctgact gtggacaagt ccagatggca gcaaggcaat gtgttcagct gctctgtgat 2640
gcatgaggcc ctgcacaacc actacacaca gaagtctctg tctctgagcc ctggcaagag 2700
aaagagaagg agtggctctg gggccaccaa cttcagcctg ctgaaacagg ctggggatgt 2760
tgaagagaac cctggaccta tggacttcca ggtgcagatc atcagctttc tgcttatctc 2820
tgccagtgtg atcatgagca ggggagacat ccagatgaca cagagccctc tgagcctgcc 2880
agtgacacct ggggaacctg ccagcatctc ttgcagaagc tctcagagcc tcctggattc 2940
tgatgatggc aacacctacc tggactggta tctgcagaag cctggccagt ctcctcagct 3000
gctgatctac accctgagct acagagccag tggggtgcca gacagattct ctggctctgg 3060
atctggcact gacttcacac tgaagattag cagagtggaa gctgaggatg tgggagtcta 3120
ctactgtatg cagaggattg agttccctct gacttttggt ggtggtacaa aggtggaaat 3180
caagaggaca gtggctgctc cttctgtgtt catcttccca ccatctgatg agcagctcaa 3240
gagtggcaca gcctctgttg tgtgtctgct gaacaacttc taccctaggg aagccaaggt 3300
gcagtggaaa gtggacaatg ccctccagtc tggcaacagc caagagagtg tgacagaaca 3360
ggacagcaag gactccacct acagcctgag cagcaccctg acactgagca aggctgacta 3420
tgagaagcac aaagtctatg cctgtgaagt gacacaccag ggactgagca gccctgtgac 3480
caagagcttc aacaggggag agtgcagctg aagatctact tctggctaat aaaagatcag 3540
agctctagtg atctgtgtgt tggttttttg tgtctgcatt ctagcagagc cccactgtgt 3600
tcatcttaca gatggaaata ctgacattca gaggagttag ttaacttgcc taggtgattc 3660
agctaataag tgcaagaaag atttcaatcc aaggtgattt gattctgaag cctgtgctaa 3720
tcacattaca ccaagctaca acttcattta taaataataa gtcagctttc aagggccttt 3780
caggtgtcct gcacttctac aagctgtgcc atttagtgaa cacaaaatga gccttctgat 3840
gaagtagtct tttcattatt tcagatatta gaacactaaa attcttagct gccagctgat 3900
tgaaggctgg gacaaaattc aaacatgcat ctacaacaat atatatctca atgttagtct 3960
ccaaattcta ttgacttcaa ctcaagagaa tataaagagc tagtctttat acactcttta 4020
aggtatgata tcatctggaa agtaacaaaa ttgatgcaaa tttgaatgaa ctttatcatg 4080
gtgtatttac acaatgtgtt tcttctccct gcaatgtatt tctttctcta attccttcca 4140
tttgatcttt catacacaat ctggttctga tgtatgtttt ttggatgcac ttttcaactc 4200
caaaagacag agctagttac tttcttcctg gtgctccaag cactgtattt gtatctgtat 4260
tcaagccctt tgcaatattg tactggatca ttatttcacc tctaggatgg cttccccagg 4320
caacttgtgt tcacccagag actacatttt gtatcttgtt gacctttgaa cttccaccag 4380
tgtctaaaaa taatatgtat gcaaaattac ttgctatgag aatgtataat taaacaatat 4440
aaaaaggaga agcaaggaga gaaacacagg tgtgtatttg tgtttgtgtg cttaaaaggc 4500
agtgtggaaa aggaagaaat gccatttata gtgaggagac aaagttatat tacctcttat 4560
ctggctttta aggagatttt gctgagctaa aaatcctata ttcatagaaa agccttacct 4620
gagttgccaa tacctcaatt cagtctagca ggagtcaatg ggaaaaaccc attggagcca 4680
agtacactga ctcaataggg actttccatt gggttttgcc cagtacataa ggtcaatagg 4740
gggtgagtca acaggaaagt cccattggag ccaagtacat tgagtcaata gggactttcc 4800
aatgggtttt gcccagtaca taaggtcaat gggaggtaag ccaatgggtt tttcccatta 4860
ctgacatgta tactgagtca ttagggactt tccaatgggt tttgcccagt acataaggtc 4920
aataggggtg aatcaacagg aaagtcccat tggagccaag tacactgagt caatagggac 4980
tttccattgg gttttgccca gtacaaaagg tcaatagggg gtgagtcaat gggtttttcc 5040
cattattggc acatacataa ggtcaatagg ggtgactagt ggagaagagc atgcttgagg 5100
gctgagtgcc cctcagtggg cagagagcac atggcccaca gtccctgaga agttgggggg 5160
aggggtgggc aattgaactg gtgcctagag aaggtggggc ttgggtaaac tgggaaagtg 5220
atgtggtgta ctggctccac ctttttcccc agggtggggg agaaccatat ataagtgcag 5280
tagtctctgt gaacattcaa gcttctgcct tctccctcct gtgagtttgg taagtcactg 5340
actgtctatg cctgggaaag ggtgggcagg agatggggca gtgcaggaaa agtggcacta 5400
tgaaccctgc agccctagac aattgtacta accttcttct ctttcctctc ctgacaggtt 5460
ggtaaccaag ccaccatggg atggtccctg atcctgctgt ttctggtggc tgtggccacc 5520
agagtgctgt ctcaggttca gctggtgcag tctggggctg aagtgaagaa acctggggcc 5580
tctgtgaagg tgtcctgcaa ggcttctggc tacacattca caggctacta catgcactgg 5640
gtcagacagg cccctggaca gggacttgag tggatgggca gaatcaaccc caacagtggt 5700
ggcaccaact atgcccagaa attccagggc agagtgacca tgaccagaga caccagcatc 5760
agcacagcct acatggaact gagcaggctt aggagtgatg acactgctgt gtactactgt 5820
gccagagtgc cctactgcag cagcacctct tgtcacagag actggtactt tgacctgtgg 5880
ggcagaggca ccctggtcac agttagctct gccagcacaa agggcccctc tgtgtttcct 5940
ctggctccca gcagcaagag caccagtggt ggaacagctg ccctgggctg tctggtcaag 6000
gactactttc ctgagcctgt gacagtgtcc tggaactctg gggctctgac atctggggtg 6060
cacacattcc ctgctgtgct gcagtcctct ggcctgtaca gcctgtcctc tgtggtcact 6120
gtgcctagct ctagcctggg cacccagacc tacatctgca atgtgaacca caagcctagc 6180
aacaccaagg tggacaagaa ggctgagccc aagagctgtg ataagaccca cacctgtcct 6240
ccatgtcctg ctccagagct gcttggagga ccatcagtgt ttctgttccc tccaaagcct 6300
aaggacaccc tgatgatcag cagaacccct gaagtgacct gtgtggtggt ggatgtgtcc 6360
catgaggacc cagaagtgaa gttcaattgg tatgtggatg gtgttgaggt gcacaatgcc 6420
aagaccaagc ctagagagga acagtacaac agcacctaca gagtggtgtc tgtgctgaca 6480
gtgctgcacc aggactggct gaatggcaaa gagtacaagt gcaaggtgtc caacaaggcc 6540
ctgcctgctc ctattgaaaa gaccatcagc aaggccaagg gccagcctag ggaaccccaa 6600
gtgtataccc tgcctcctag cagagatgag ctgaccaaga accaggtgtc cctgacatgc 6660
ctggttaagg gcttctaccc ctctgacatt gctgtggaat gggagagcaa tggccagcct 6720
gagaacaact acaagaccac acctcctgtg ctggactctg atggctcatt cttcctgtac 6780
tccaagctga ctgtggacaa gtccagatgg cagcaaggca atgtgttcag ctgctctgtg 6840
atgcatgagg ccctgcacaa ccactacaca cagaagtctc tgtctctgag ccctggcaag 6900
agaaagagaa ggagtggctc tggggccacc aacttcagcc tgctgaaaca ggctggggat 6960
gttgaagaga accctggacc tatggacttc caggtgcaga tcatcagctt tctgcttatc 7020
tctgccagtg tgatcatgag caggggagac atccagatga cacagagccc tctgagcctg 7080
ccagtgacac ctggggaacc tgccagcatc tcttgcagaa gctctcagag cctcctggat 7140
tctgatgatg gcaacaccta cctggactgg tatctgcaga agcctggcca gtctcctcag 7200
ctgctgatct acaccctgag ctacagagcc agtggggtgc cagacagatt ctctggctct 7260
ggatctggca ctgacttcac actgaagatt agcagagtgg aagctgagga tgtgggagtc 7320
tactactgta tgcagaggat tgagttccct ctgacttttg gtggtggtac aaaggtggaa 7380
atcaagagga cagtggctgc tccttctgtg ttcatcttcc caccatctga tgagcagctc 7440
aagagtggca cagcctctgt tgtgtgtctg ctgaacaact tctaccctag ggaagccaag 7500
gtgcagtgga aagtggacaa tgccctccag tctggcaaca gccaagagag tgtgacagaa 7560
caggacagca aggactccac ctacagcctg agcagcaccc tgacactgag caaggctgac 7620
tatgagaagc acaaagtcta tgcctgtgaa gtgacacacc agggactgag cagccctgtg 7680
accaagagct tcaacagggg agagtgcagc tgaagatcta cttctggcta ataaaagatc 7740
agagctctag tgatctgtgt gttggttttt tgtgtctgca ttctagcaag tcaatatgtt 7800
caccccaaaa aagctgtttg ttaacttgtc aacctcattc taaaatgtat atagaagccc 7860
aaaagacaat aacaaaaata ttcttgtaga acaaaatggg aaagaatgtt ccactaaata 7920
tcaagattta gagcaaagca tgagatgtgt ggggatagac agtgaggctg ataaaataga 7980
gtagagctca gaaacagacc cattgatata tgtaagtgac ctatgaaaaa aatatggcat 8040
tttacaatgg gaaaatgatg gtctttttct tttttagaaa aacagggaaa tatatttata 8100
tgtaaaaaat aaaagggaac ccatatgtca taccatacac acaaaaaaat tccagtgaat 8160
tataagtcta aatggagaag gcaaaacttt aaatctttta gaaaataata tagaagcatg 8220
ccatcaagac ttcagtgtag agaaaaattt cttatgactc aaagtcctaa ccacaaagaa 8280
aagattgtta attagattgc atgaatatta agacttattt ttaaaattaa aaaaccatta 8340
agaaaagtca ggccatagaa tgacagaaaa tatttgcaac accccagtaa agagaattgt 8400
aatatgcaga ttataaaaag aagtcttaca aatcagtaaa aaataaaact agacaaaaat 8460
ttgaacagat gaaagagaaa ctctaaataa tcattacaca tgagaaactc aatctcagaa 8520
atcagagaac tatcattgca tatacactaa attagagaaa tattaaaagg ctaagtaaca 8580
tctgtggctt aattaatcta gctctagtga tcagcagttc aacctgttga tagtatgtac 8640
taagctctca tgtttaatgt actaagctct catgtttaat gaactaaacc ctcatggcta 8700
atgtactaag ctctcatggc taatgtacta agctctcatg tttcatgtac taagctctca 8760
tgtttgaaca ataaaattaa tataaatcag caacttaaat agcctctaag gttttaagtt 8820
ttataagaaa aaaaagaata tataaggctt ttaaaggttt taaggtttcc taggttatcc 8880
tcatatgagc tcttagaaaa actcatccag catcaaatga aactgcaatt tattcatatc 8940
aggattatca ataccatatt tttgaaaaag tcttttctgt aatgaaggag aaaactcacc 9000
caggcagttc cataggatgg caagatcctg gtatctgtct gcaattccaa ctcttccaac 9060
atcaatacaa cctattaatt tcccctcatc aaaaataagg ttatcaagtg agaaatcacc 9120
atgagtgacc actgaatctg gtgagaatgg caaaagatta tgcatttctt tccagacttg 9180
ttcaacaggc cagccatttc tctcatcatc aaaatcactg gcatcaacca aaccattatt 9240
cattcttgat tgggcctgag ccagtctaaa tactctatca gagttaaaag gacaattaca 9300
aacaggaatg gaatgcaatc ttctcaggaa cactgccagg gcatcaacaa tattttcacc 9360
tgaatcagga tattcttcca atacctggaa tgctgttttc cctgggatgg cagtggtgag 9420
taaccatgca tcatcaggag ttctgataaa atgcttgatg gttggaagag gcataaattc 9480
agtcagccag tttagtctga ccatctcatc tgtaacatca ttggcaacag aacctttgcc 9540
atgtttcaga aacaactctg gggcatctgg cttcccatac aatctataga ttgtggcacc 9600
tgattgccca acattatctc tagcccattt atacccatat aaatcagcat ccatgttgga 9660
atttaatctt ggcctggagc aagaggtttc tctttgaata tggctcatac atgtgcacct 9720
cctatagtga gttgtattat actatgcaga tatactatgc caatgtttaa ttgtcag 9777
<210> 15
<211> 5584
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic
<400> 15
cactatgtgt taattaaaat tatctctaag gcatgtgaac tggctgtctt ggttttcatc 60
tgtacttcat ctgctacctc tgtgacctga aacatattta taattccatt aagctgtgca 120
tatgatagat ttatcatatg tattttcctt aaaggatttt tgtaagaact aattgaattg 180
atacctgtaa agtctttatc acactaccca ataaataata aatctctttg ttcagctctc 240
tgtttctata aatatgtacc agttttattg tttttagtgg tagtgatttt attctctttc 300
tatatatata cacacacatg tgtgcattca taaatatata caatttttat gaataaaaaa 360
ttattagcaa tcaatattga aaaccactga tttttgttta tgtgagcaaa cagcagatta 420
aaaggaattt gaattctcat agctagcagg agtcaatggg aaaaacccat tggagccaag 480
tacactgact caatagggac tttccattgg gttttgccca gtacataagg tcaatagggg 540
gtgagtcaac aggaaagtcc cattggagcc aagtacattg agtcaatagg gactttccaa 600
tgggttttgc ccagtacata aggtcaatgg gaggtaagcc aatgggtttt tcccattact 660
gacatgtata ctgagtcatt agggactttc caatgggttt tgcccagtac ataaggtcaa 720
taggggtgaa tcaacaggaa agtcccattg gagccaagta cactgagtca atagggactt 780
tccattgggt tttgcccagt acaaaaggtc aatagggggt gagtcaatgg gtttttccca 840
ttattggcac atacataagg tcaatagggg tgactagtgg agaagagcat gcttgagggc 900
tgagtgcccc tcagtgggca gagagcacat ggcccacagt ccctgagaag ttggggggag 960
gggtgggcaa ttgaactggt gcctagagaa ggtggggctt gggtaaactg ggaaagtgat 1020
gtggtgtact ggctccacct ttttccccag ggtgggggag aaccatatat aagtgcagta 1080
gtctctgtga acattcaagc ttctgccttc tccctcctgt gagtttggta agtcactgac 1140
tgtctatgcc tgggaaaggg tgggcaggag atggggcagt gcaggaaaag tggcactatg 1200
aaccctgcag ccctagacaa ttgtactaac cttcttctct ttcctctcct gacaggttgg 1260
taaccaagcc accatgaact ttggcctgag cctgatcttc ctggtgctga tcctgaaagg 1320
ggtgcagtgt gaagtgcagc tggtggaatc tggggctgaa gtgaagaaac ctggggcctc 1380
tgtgaaggtg tcctgcaaag tgtctggcta caccctgaca gagctgagca tgcactgggt 1440
cagacaggcc cctggcaaag gccttgaatg gatgggaggc tttgaccctg aggatgggga 1500
gactatgtat gcccagaaat tccagggcag agtgaccatg acagaggaca ccagcacaga 1560
cacagcctac atggaactga gcagccttag gagtgaagat acagctgtgt actactgtgc 1620
caccagcact gctgtggctg gcacccctga cctgtttgac tactactatg gcatggatgt 1680
gtggggccag ggcaccacag tgacagtcag ctctgcttcc acaaagggcc cctctgtgtt 1740
ccctctggct cctagcagca agagcaccag tggtggaaca gctgccctgg gctgtctggt 1800
caaggactac tttcctgagc cagtgactgt gtcctggaac agtggggctc tgacatctgg 1860
ggtgcacaca ttccctgctg tgctccagtc ctctggcctg tacagcctct cctctgtggt 1920
cactgtgcca agctctagcc tgggcaccca gacctacatc tgcaatgtga accacaagcc 1980
tagcaacacc aaggtggaca agaaggctga gcccaagagc tgtgacaaga cccacacctg 2040
tcctccatgt cctgctccag agctgcttgg aggaccttct gtgtttctgt tccctccaaa 2100
gcctaaggac accctgatga tcagcagaac ccctgaagtg acctgtgtgg tggtggatgt 2160
gtcccatgag gacccagaag tgaagttcaa ttggtatgtg gatggtgttg aggtgcacaa 2220
tgccaagacc aagcctagag aggaacagta caacagcacc tacagagtgg tgtcagtgct 2280
gacagtgctg caccaggact ggctgaatgg caaagagtac aagtgcaagg tgtccaacaa 2340
ggccctgcct gctcctattg aaaagaccat cagcaaggcc aagggccagc ctagggaacc 2400
ccaagtgtat accctgccac ctagcagaga tgagctgacc aagaaccagg tgtccctgac 2460
atgcctggtt aagggcttct acccctctga cattgctgtg gaatgggaga gcaatggcca 2520
gcctgagaac aactacaaga caacccctcc tgtgctggac tctgatggct cattcttcct 2580
gtactccaag ctcacagtgg acaagtccag atggcagcaa ggcaatgtgt tcagctgctc 2640
tgtgatgcat gaggccctgc acaaccacta cacacagaag tccctgtctc tgagccctgg 2700
caagagaaag agaaggagtg gctctggggc caccaacttc agcctgctga aacaggctgg 2760
ggatgttgaa gagaaccctg gacctatggc ctgggctctg ctgctgctgg gactgctgtc 2820
tcactgcaca ggctctgtga cagagattgt gatgacacag agccctctgt ctagccctgt 2880
gacactggga cagcctgcca gcatcagctg tagaagctct cagagtctgg tgcattctga 2940
tggcaacacc tacctgagct ggctgcaaca gaggcctgga cagccaccta gactgctgat 3000
ctacaagatc agcaacaggt tctctggggt cccagacaga ttctctggaa gtggtgctgg 3060
cacagacttc actctgaaga ttagcagagt ggaagctgag gatgttgggg tgtactattg 3120
cacccaggcc acacagttcc cttacacctt tggccaggga acaaaagtgg acatcaaggg 3180
caccaaactg actgtgctgg gccagccaaa ggctgcccct tctgtgactc tgtttccacc 3240
tagctctgag gaactccagg ctaacaaggc cacacttgtg tgcctgatct ctgacttcta 3300
ccctggggct gtgacagtgg cctggaaggc tgatagcagc ccagtgaagg ctggggttga 3360
gacaaccaca cctagcaagc agagcaacaa caaatatgct gccagcagct acctgagtct 3420
gacccctgag cagtggaagt cccacagatc ctacagctgc caagtgaccc atgagggctc 3480
tacagtggaa aagactgtgg ccccaacaga gtgcagctga agatctactt ctggctaata 3540
aaagatcaga gctctagtga tctgtgtgtt ggttttttgt gtctgcattc tagcaagtca 3600
atatgttcac cccaaaaaag ctgtttgtta acttgtcaac ctcattctaa aatgtatata 3660
gaagcccaaa agacaataac aaaaatattc ttgtagaaca aaatgggaaa gaatgttcca 3720
ctaaatatca agatttagag caaagcatga gatgtgtggg gatagacagt gaggctgata 3780
aaatagagta gagctcagaa acagacccat tgatatatgt aagtgaccta tgaaaaaaat 3840
atggcatttt acaatgggaa aatgatggtc tttttctttt ttagaaaaac agggaaatat 3900
atttatatgt aaaaaataaa agggaaccca tatgtcatac catacacaca aaaaaattcc 3960
agtgaattat aagtctaaat ggagaaggca aaactttaaa tcttttagaa aataatatag 4020
aagcatgcca tcaagacttc agtgtagaga aaaatttctt atgactcaaa gtcctaacca 4080
caaagaaaag attgttaatt agattgcatg aatattaaga cttattttta aaattaaaaa 4140
accattaaga aaagtcaggc catagaatga cagaaaatat ttgcaacacc ccagtaaaga 4200
gaattgtaat atgcagatta taaaaagaag tcttacaaat cagtaaaaaa taaaactaga 4260
caaaaatttg aacagatgaa agagaaactc taaataatca ttacacatga gaaactcaat 4320
ctcagaaatc agagaactat cattgcatat acactaaatt agagaaatat taaaaggcta 4380
agtaacatct gtggcttaat taatctagct ctagtgatca gcagttcaac ctgttgatag 4440
tatgtactaa gctctcatgt ttaatgtact aagctctcat gtttaatgaa ctaaaccctc 4500
atggctaatg tactaagctc tcatggctaa tgtactaagc tctcatgttt catgtactaa 4560
gctctcatgt ttgaacaata aaattaatat aaatcagcaa cttaaatagc ctctaaggtt 4620
ttaagtttta taagaaaaaa aagaatatat aaggctttta aaggttttaa ggtttcctag 4680
gttatcctca tatgagctct tagaaaaact catccagcat caaatgaaac tgcaatttat 4740
tcatatcagg attatcaata ccatattttt gaaaaagtct tttctgtaat gaaggagaaa 4800
actcacccag gcagttccat aggatggcaa gatcctggta tctgtctgca attccaactc 4860
ttccaacatc aatacaacct attaatttcc cctcatcaaa aataaggtta tcaagtgaga 4920
aatcaccatg agtgaccact gaatctggtg agaatggcaa aagattatgc atttctttcc 4980
agacttgttc aacaggccag ccatttctct catcatcaaa atcactggca tcaaccaaac 5040
cattattcat tcttgattgg gcctgagcca gtctaaatac tctatcagag ttaaaaggac 5100
aattacaaac aggaatggaa tgcaatcttc tcaggaacac tgccagggca tcaacaatat 5160
tttcacctga atcaggatat tcttccaata cctggaatgc tgttttccct gggatggcag 5220
tggtgagtaa ccatgcatca tcaggagttc tgataaaatg cttgatggtt ggaagaggca 5280
taaattcagt cagccagttt agtctgacca tctcatctgt aacatcattg gcaacagaac 5340
ctttgccatg tttcagaaac aactctgggg catctggctt cccatacaat ctatagattg 5400
tggcacctga ttgcccaaca ttatctctag cccatttata cccatataaa tcagcatcca 5460
tgttggaatt taatcttggc ctggagcaag aggtttctct ttgaatatgg ctcatacatg 5520
tgcacctcct atagtgagtt gtattatact atgcagatat actatgccaa tgtttaattg 5580
tcag 5584
<210> 16
<211> 9795
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic
<400> 16
cactatgtgt taattaaaat tatctctaag gcatgtgaac tggctgtctt ggttttcatc 60
tgtacttcat ctgctacctc tgtgacctga aacatattta taattccatt aagctgtgca 120
tatgatagat ttatcatatg tattttcctt aaaggatttt tgtaagaact aattgaattg 180
atacctgtaa agtctttatc acactaccca ataaataata aatctctttg ttcagctctc 240
tgtttctata aatatgtacc agttttattg tttttagtgg tagtgatttt attctctttc 300
tatatatata cacacacatg tgtgcattca taaatatata caatttttat gaataaaaaa 360
ttattagcaa tcaatattga aaaccactga tttttgttta tgtgagcaaa cagcagatta 420
aaaggaattt gaattctcat agctagcagg agtcaatggg aaaaacccat tggagccaag 480
tacactgact caatagggac tttccattgg gttttgccca gtacataagg tcaatagggg 540
gtgagtcaac aggaaagtcc cattggagcc aagtacattg agtcaatagg gactttccaa 600
tgggttttgc ccagtacata aggtcaatgg gaggtaagcc aatgggtttt tcccattact 660
gacatgtata ctgagtcatt agggactttc caatgggttt tgcccagtac ataaggtcaa 720
taggggtgaa tcaacaggaa agtcccattg gagccaagta cactgagtca atagggactt 780
tccattgggt tttgcccagt acaaaaggtc aatagggggt gagtcaatgg gtttttccca 840
ttattggcac atacataagg tcaatagggg tgactagtgg agaagagcat gcttgagggc 900
tgagtgcccc tcagtgggca gagagcacat ggcccacagt ccctgagaag ttggggggag 960
gggtgggcaa ttgaactggt gcctagagaa ggtggggctt gggtaaactg ggaaagtgat 1020
gtggtgtact ggctccacct ttttccccag ggtgggggag aaccatatat aagtgcagta 1080
gtctctgtga acattcaagc ttctgccttc tccctcctgt gagtttggta agtcactgac 1140
tgtctatgcc tgggaaaggg tgggcaggag atggggcagt gcaggaaaag tggcactatg 1200
aaccctgcag ccctagacaa ttgtactaac cttcttctct ttcctctcct gacaggttgg 1260
taaccaagcc accatgaact ttggcctgag cctgatcttc ctggtgctga tcctgaaagg 1320
ggtgcagtgt gaagtgcagc tggtggaatc tggggctgaa gtgaagaaac ctggggcctc 1380
tgtgaaggtg tcctgcaaag tgtctggcta caccctgaca gagctgagca tgcactgggt 1440
cagacaggcc cctggcaaag gccttgaatg gatgggaggc tttgaccctg aggatgggga 1500
gactatgtat gcccagaaat tccagggcag agtgaccatg acagaggaca ccagcacaga 1560
cacagcctac atggaactga gcagccttag gagtgaagat acagctgtgt actactgtgc 1620
caccagcact gctgtggctg gcacccctga cctgtttgac tactactatg gcatggatgt 1680
gtggggccag ggcaccacag tgacagtcag ctctgcttcc acaaagggcc cctctgtgtt 1740
ccctctggct cctagcagca agagcaccag tggtggaaca gctgccctgg gctgtctggt 1800
caaggactac tttcctgagc cagtgactgt gtcctggaac agtggggctc tgacatctgg 1860
ggtgcacaca ttccctgctg tgctccagtc ctctggcctg tacagcctct cctctgtggt 1920
cactgtgcca agctctagcc tgggcaccca gacctacatc tgcaatgtga accacaagcc 1980
tagcaacacc aaggtggaca agaaggctga gcccaagagc tgtgacaaga cccacacctg 2040
tcctccatgt cctgctccag agctgcttgg aggaccttct gtgtttctgt tccctccaaa 2100
gcctaaggac accctgatga tcagcagaac ccctgaagtg acctgtgtgg tggtggatgt 2160
gtcccatgag gacccagaag tgaagttcaa ttggtatgtg gatggtgttg aggtgcacaa 2220
tgccaagacc aagcctagag aggaacagta caacagcacc tacagagtgg tgtcagtgct 2280
gacagtgctg caccaggact ggctgaatgg caaagagtac aagtgcaagg tgtccaacaa 2340
ggccctgcct gctcctattg aaaagaccat cagcaaggcc aagggccagc ctagggaacc 2400
ccaagtgtat accctgccac ctagcagaga tgagctgacc aagaaccagg tgtccctgac 2460
atgcctggtt aagggcttct acccctctga cattgctgtg gaatgggaga gcaatggcca 2520
gcctgagaac aactacaaga caacccctcc tgtgctggac tctgatggct cattcttcct 2580
gtactccaag ctcacagtgg acaagtccag atggcagcaa ggcaatgtgt tcagctgctc 2640
tgtgatgcat gaggccctgc acaaccacta cacacagaag tccctgtctc tgagccctgg 2700
caagagaaag agaaggagtg gctctggggc caccaacttc agcctgctga aacaggctgg 2760
ggatgttgaa gagaaccctg gacctatggc ctgggctctg ctgctgctgg gactgctgtc 2820
tcactgcaca ggctctgtga cagagattgt gatgacacag agccctctgt ctagccctgt 2880
gacactggga cagcctgcca gcatcagctg tagaagctct cagagtctgg tgcattctga 2940
tggcaacacc tacctgagct ggctgcaaca gaggcctgga cagccaccta gactgctgat 3000
ctacaagatc agcaacaggt tctctggggt cccagacaga ttctctggaa gtggtgctgg 3060
cacagacttc actctgaaga ttagcagagt ggaagctgag gatgttgggg tgtactattg 3120
cacccaggcc acacagttcc cttacacctt tggccaggga acaaaagtgg acatcaaggg 3180
caccaaactg actgtgctgg gccagccaaa ggctgcccct tctgtgactc tgtttccacc 3240
tagctctgag gaactccagg ctaacaaggc cacacttgtg tgcctgatct ctgacttcta 3300
ccctggggct gtgacagtgg cctggaaggc tgatagcagc ccagtgaagg ctggggttga 3360
gacaaccaca cctagcaagc agagcaacaa caaatatgct gccagcagct acctgagtct 3420
gacccctgag cagtggaagt cccacagatc ctacagctgc caagtgaccc atgagggctc 3480
tacagtggaa aagactgtgg ccccaacaga gtgcagctga agatctactt ctggctaata 3540
aaagatcaga gctctagtga tctgtgtgtt ggttttttgt gtctgcattc tagcagagcc 3600
ccactgtgtt catcttacag atggaaatac tgacattcag aggagttagt taacttgcct 3660
aggtgattca gctaataagt gcaagaaaga tttcaatcca aggtgatttg attctgaagc 3720
ctgtgctaat cacattacac caagctacaa cttcatttat aaataataag tcagctttca 3780
agggcctttc aggtgtcctg cacttctaca agctgtgcca tttagtgaac acaaaatgag 3840
ccttctgatg aagtagtctt ttcattattt cagatattag aacactaaaa ttcttagctg 3900
ccagctgatt gaaggctggg acaaaattca aacatgcatc tacaacaata tatatctcaa 3960
tgttagtctc caaattctat tgacttcaac tcaagagaat ataaagagct agtctttata 4020
cactctttaa ggtatgatat catctggaaa gtaacaaaat tgatgcaaat ttgaatgaac 4080
tttatcatgg tgtatttaca caatgtgttt cttctccctg caatgtattt ctttctctaa 4140
ttccttccat ttgatctttc atacacaatc tggttctgat gtatgttttt tggatgcact 4200
tttcaactcc aaaagacaga gctagttact ttcttcctgg tgctccaagc actgtatttg 4260
tatctgtatt caagcccttt gcaatattgt actggatcat tatttcacct ctaggatggc 4320
ttccccaggc aacttgtgtt cacccagaga ctacattttg tatcttgttg acctttgaac 4380
ttccaccagt gtctaaaaat aatatgtatg caaaattact tgctatgaga atgtataatt 4440
aaacaatata aaaaggagaa gcaaggagag aaacacaggt gtgtatttgt gtttgtgtgc 4500
ttaaaaggca gtgtggaaaa ggaagaaatg ccatttatag tgaggagaca aagttatatt 4560
acctcttatc tggcttttaa ggagattttg ctgagctaaa aatcctatat tcatagaaaa 4620
gccttacctg agttgccaat acctcaattc agtctagcag gagtcaatgg gaaaaaccca 4680
ttggagccaa gtacactgac tcaataggga ctttccattg ggttttgccc agtacataag 4740
gtcaataggg ggtgagtcaa caggaaagtc ccattggagc caagtacatt gagtcaatag 4800
ggactttcca atgggttttg cccagtacat aaggtcaatg ggaggtaagc caatgggttt 4860
ttcccattac tgacatgtat actgagtcat tagggacttt ccaatgggtt ttgcccagta 4920
cataaggtca ataggggtga atcaacagga aagtcccatt ggagccaagt acactgagtc 4980
aatagggact ttccattggg ttttgcccag tacaaaaggt caataggggg tgagtcaatg 5040
ggtttttccc attattggca catacataag gtcaataggg gtgactagtg gagaagagca 5100
tgcttgaggg ctgagtgccc ctcagtgggc agagagcaca tggcccacag tccctgagaa 5160
gttgggggga ggggtgggca attgaactgg tgcctagaga aggtggggct tgggtaaact 5220
gggaaagtga tgtggtgtac tggctccacc tttttcccca gggtggggga gaaccatata 5280
taagtgcagt agtctctgtg aacattcaag cttctgcctt ctccctcctg tgagtttggt 5340
aagtcactga ctgtctatgc ctgggaaagg gtgggcagga gatggggcag tgcaggaaaa 5400
gtggcactat gaaccctgca gccctagaca attgtactaa ccttcttctc tttcctctcc 5460
tgacaggttg gtaaccaagc caccatgaac tttggcctga gcctgatctt cctggtgctg 5520
atcctgaaag gggtgcagtg tgaagtgcag ctggtggaat ctggggctga agtgaagaaa 5580
cctggggcct ctgtgaaggt gtcctgcaaa gtgtctggct acaccctgac agagctgagc 5640
atgcactggg tcagacaggc ccctggcaaa ggccttgaat ggatgggagg ctttgaccct 5700
gaggatgggg agactatgta tgcccagaaa ttccagggca gagtgaccat gacagaggac 5760
accagcacag acacagccta catggaactg agcagcctta ggagtgaaga tacagctgtg 5820
tactactgtg ccaccagcac tgctgtggct ggcacccctg acctgtttga ctactactat 5880
ggcatggatg tgtggggcca gggcaccaca gtgacagtca gctctgcttc cacaaagggc 5940
ccctctgtgt tccctctggc tcctagcagc aagagcacca gtggtggaac agctgccctg 6000
ggctgtctgg tcaaggacta ctttcctgag ccagtgactg tgtcctggaa cagtggggct 6060
ctgacatctg gggtgcacac attccctgct gtgctccagt cctctggcct gtacagcctc 6120
tcctctgtgg tcactgtgcc aagctctagc ctgggcaccc agacctacat ctgcaatgtg 6180
aaccacaagc ctagcaacac caaggtggac aagaaggctg agcccaagag ctgtgacaag 6240
acccacacct gtcctccatg tcctgctcca gagctgcttg gaggaccttc tgtgtttctg 6300
ttccctccaa agcctaagga caccctgatg atcagcagaa cccctgaagt gacctgtgtg 6360
gtggtggatg tgtcccatga ggacccagaa gtgaagttca attggtatgt ggatggtgtt 6420
gaggtgcaca atgccaagac caagcctaga gaggaacagt acaacagcac ctacagagtg 6480
gtgtcagtgc tgacagtgct gcaccaggac tggctgaatg gcaaagagta caagtgcaag 6540
gtgtccaaca aggccctgcc tgctcctatt gaaaagacca tcagcaaggc caagggccag 6600
cctagggaac cccaagtgta taccctgcca cctagcagag atgagctgac caagaaccag 6660
gtgtccctga catgcctggt taagggcttc tacccctctg acattgctgt ggaatgggag 6720
agcaatggcc agcctgagaa caactacaag acaacccctc ctgtgctgga ctctgatggc 6780
tcattcttcc tgtactccaa gctcacagtg gacaagtcca gatggcagca aggcaatgtg 6840
ttcagctgct ctgtgatgca tgaggccctg cacaaccact acacacagaa gtccctgtct 6900
ctgagccctg gcaagagaaa gagaaggagt ggctctgggg ccaccaactt cagcctgctg 6960
aaacaggctg gggatgttga agagaaccct ggacctatgg cctgggctct gctgctgctg 7020
ggactgctgt ctcactgcac aggctctgtg acagagattg tgatgacaca gagccctctg 7080
tctagccctg tgacactggg acagcctgcc agcatcagct gtagaagctc tcagagtctg 7140
gtgcattctg atggcaacac ctacctgagc tggctgcaac agaggcctgg acagccacct 7200
agactgctga tctacaagat cagcaacagg ttctctgggg tcccagacag attctctgga 7260
agtggtgctg gcacagactt cactctgaag attagcagag tggaagctga ggatgttggg 7320
gtgtactatt gcacccaggc cacacagttc ccttacacct ttggccaggg aacaaaagtg 7380
gacatcaagg gcaccaaact gactgtgctg ggccagccaa aggctgcccc ttctgtgact 7440
ctgtttccac ctagctctga ggaactccag gctaacaagg ccacacttgt gtgcctgatc 7500
tctgacttct accctggggc tgtgacagtg gcctggaagg ctgatagcag cccagtgaag 7560
gctggggttg agacaaccac acctagcaag cagagcaaca acaaatatgc tgccagcagc 7620
tacctgagtc tgacccctga gcagtggaag tcccacagat cctacagctg ccaagtgacc 7680
catgagggct ctacagtgga aaagactgtg gccccaacag agtgcagctg aagatctact 7740
tctggctaat aaaagatcag agctctagtg atctgtgtgt tggttttttg tgtctgcatt 7800
ctagcaagtc aatatgttca ccccaaaaaa gctgtttgtt aacttgtcaa cctcattcta 7860
aaatgtatat agaagcccaa aagacaataa caaaaatatt cttgtagaac aaaatgggaa 7920
agaatgttcc actaaatatc aagatttaga gcaaagcatg agatgtgtgg ggatagacag 7980
tgaggctgat aaaatagagt agagctcaga aacagaccca ttgatatatg taagtgacct 8040
atgaaaaaaa tatggcattt tacaatggga aaatgatggt ctttttcttt tttagaaaaa 8100
cagggaaata tatttatatg taaaaaataa aagggaaccc atatgtcata ccatacacac 8160
aaaaaaattc cagtgaatta taagtctaaa tggagaaggc aaaactttaa atcttttaga 8220
aaataatata gaagcatgcc atcaagactt cagtgtagag aaaaatttct tatgactcaa 8280
agtcctaacc acaaagaaaa gattgttaat tagattgcat gaatattaag acttattttt 8340
aaaattaaaa aaccattaag aaaagtcagg ccatagaatg acagaaaata tttgcaacac 8400
cccagtaaag agaattgtaa tatgcagatt ataaaaagaa gtcttacaaa tcagtaaaaa 8460
ataaaactag acaaaaattt gaacagatga aagagaaact ctaaataatc attacacatg 8520
agaaactcaa tctcagaaat cagagaacta tcattgcata tacactaaat tagagaaata 8580
ttaaaaggct aagtaacatc tgtggcttaa ttaatctagc tctagtgatc agcagttcaa 8640
cctgttgata gtatgtacta agctctcatg tttaatgtac taagctctca tgtttaatga 8700
actaaaccct catggctaat gtactaagct ctcatggcta atgtactaag ctctcatgtt 8760
tcatgtacta agctctcatg tttgaacaat aaaattaata taaatcagca acttaaatag 8820
cctctaaggt tttaagtttt ataagaaaaa aaagaatata taaggctttt aaaggtttta 8880
aggtttccta ggttatcctc atatgagctc ttagaaaaac tcatccagca tcaaatgaaa 8940
ctgcaattta ttcatatcag gattatcaat accatatttt tgaaaaagtc ttttctgtaa 9000
tgaaggagaa aactcaccca ggcagttcca taggatggca agatcctggt atctgtctgc 9060
aattccaact cttccaacat caatacaacc tattaatttc ccctcatcaa aaataaggtt 9120
atcaagtgag aaatcaccat gagtgaccac tgaatctggt gagaatggca aaagattatg 9180
catttctttc cagacttgtt caacaggcca gccatttctc tcatcatcaa aatcactggc 9240
atcaaccaaa ccattattca ttcttgattg ggcctgagcc agtctaaata ctctatcaga 9300
gttaaaagga caattacaaa caggaatgga atgcaatctt ctcaggaaca ctgccagggc 9360
atcaacaata ttttcacctg aatcaggata ttcttccaat acctggaatg ctgttttccc 9420
tgggatggca gtggtgagta accatgcatc atcaggagtt ctgataaaat gcttgatggt 9480
tggaagaggc ataaattcag tcagccagtt tagtctgacc atctcatctg taacatcatt 9540
ggcaacagaa cctttgccat gtttcagaaa caactctggg gcatctggct tcccatacaa 9600
tctatagatt gtggcacctg attgcccaac attatctcta gcccatttat acccatataa 9660
atcagcatcc atgttggaat ttaatcttgg cctggagcaa gaggtttctc tttgaatatg 9720
gctcatacat gtgcacctcc tatagtgagt tgtattatac tatgcagata tactatgcca 9780
atgtttaatt gtcag 9795
<210> 17
<211> 8671
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic
<400> 17
cactatgtgt taattaaaat tatctctaag gcatgtgaac tggctgtctt ggttttcatc 60
tgtacttcat ctgctacctc tgtgacctga aacatattta taattccatt aagctgtgca 120
tatgatagat ttatcatatg tattttcctt aaaggatttt tgtaagaact aattgaattg 180
atacctgtaa agtctttatc acactaccca ataaataata aatctctttg ttcagctctc 240
tgtttctata aatatgtacc agttttattg tttttagtgg tagtgatttt attctctttc 300
tatatatata cacacacatg tgtgcattca taaatatata caatttttat gaataaaaaa 360
ttattagcaa tcaatattga aaaccactga tttttgttta tgtgagcaaa cagcagatta 420
aaaggaattt gaattctcat agctagcagg agtcaatggg aaaaacccat tggagccaag 480
tacactgact caatagggac tttccattgg gttttgccca gtacataagg tcaatagggg 540
gtgagtcaac aggaaagtcc cattggagcc aagtacattg agtcaatagg gactttccaa 600
tgggttttgc ccagtacata aggtcaatgg gaggtaagcc aatgggtttt tcccattact 660
gacatgtata ctgagtcatt agggactttc caatgggttt tgcccagtac ataaggtcaa 720
taggggtgaa tcaacaggaa agtcccattg gagccaagta cactgagtca atagggactt 780
tccattgggt tttgcccagt acaaaaggtc aatagggggt gagtcaatgg gtttttccca 840
ttattggcac atacataagg tcaatagggg tgactagtgg agaagagcat gcttgagggc 900
tgagtgcccc tcagtgggca gagagcacat ggcccacagt ccctgagaag ttggggggag 960
gggtgggcaa ttgaactggt gcctagagaa ggtggggctt gggtaaactg ggaaagtgat 1020
gtggtgtact ggctccacct ttttccccag ggtgggggag aaccatatat aagtgcagta 1080
gtctctgtga acattcaagc ttctgccttc tccctcctgt gagtttggta agtcactgac 1140
tgtctatgcc tgggaaaggg tgggcaggag atggggcagt gcaggaaaag tggcactatg 1200
aaccctgcag ccctagacaa ttgtactaac cttcttctct ttcctctcct gacaggttgg 1260
taaccaagcc accatgaact ttggcctgag cctgatcttc ctggtgctga tcctgaaagg 1320
ggtgcagtgt gaagtgcagc tggtggaatc tggggctgaa gtgaagaaac ctggggcctc 1380
tgtgaaggtg tcctgcaaag tgtctggcta caccctgaca gagctgagca tgcactgggt 1440
cagacaggcc cctggcaaag gccttgaatg gatgggaggc tttgaccctg aggatgggga 1500
gactatgtat gcccagaaat tccagggcag agtgaccatg acagaggaca ccagcacaga 1560
cacagcctac atggaactga gcagccttag gagtgaagat acagctgtgt actactgtgc 1620
caccagcact gctgtggctg gcacccctga cctgtttgac tactactatg gcatggatgt 1680
gtggggccag ggcaccacag tgacagtcag ctctgcttcc acaaagggcc cctctgtgtt 1740
ccctctggct cctagcagca agagcaccag tggtggaaca gctgccctgg gctgtctggt 1800
caaggactac tttcctgagc cagtgactgt gtcctggaac agtggggctc tgacatctgg 1860
ggtgcacaca ttccctgctg tgctccagtc ctctggcctg tacagcctct cctctgtggt 1920
cactgtgcca agctctagcc tgggcaccca gacctacatc tgcaatgtga accacaagcc 1980
tagcaacacc aaggtggaca agaaggctga gcccaagagc tgtgacaaga cccacacctg 2040
tcctccatgt cctgctccag agctgcttgg aggaccttct gtgtttctgt tccctccaaa 2100
gcctaaggac accctgatga tcagcagaac ccctgaagtg acctgtgtgg tggtggatgt 2160
gtcccatgag gacccagaag tgaagttcaa ttggtatgtg gatggtgttg aggtgcacaa 2220
tgccaagacc aagcctagag aggaacagta caacagcacc tacagagtgg tgtcagtgct 2280
gacagtgctg caccaggact ggctgaatgg caaagagtac aagtgcaagg tgtccaacaa 2340
ggccctgcct gctcctattg aaaagaccat cagcaaggcc aagggccagc ctagggaacc 2400
ccaagtgtat accctgccac ctagcagaga tgagctgacc aagaaccagg tgtccctgac 2460
atgcctggtt aagggcttct acccctctga cattgctgtg gaatgggaga gcaatggcca 2520
gcctgagaac aactacaaga caacccctcc tgtgctggac tctgatggct cattcttcct 2580
gtactccaag ctcacagtgg acaagtccag atggcagcaa ggcaatgtgt tcagctgctc 2640
tgtgatgcat gaggccctgc acaaccacta cacacagaag tccctgtctc tgagccctgg 2700
caagagaaag agaaggagtg gctctggggc caccaacttc agcctgctga aacaggctgg 2760
ggatgttgaa gagaaccctg gacctatggc ctgggctctg ctgctgctgg gactgctgtc 2820
tcactgcaca ggctctgtga cagagattgt gatgacacag agccctctgt ctagccctgt 2880
gacactggga cagcctgcca gcatcagctg tagaagctct cagagtctgg tgcattctga 2940
tggcaacacc tacctgagct ggctgcaaca gaggcctgga cagccaccta gactgctgat 3000
ctacaagatc agcaacaggt tctctggggt cccagacaga ttctctggaa gtggtgctgg 3060
cacagacttc actctgaaga ttagcagagt ggaagctgag gatgttgggg tgtactattg 3120
cacccaggcc acacagttcc cttacacctt tggccaggga acaaaagtgg acatcaaggg 3180
caccaaactg actgtgctgg gccagccaaa ggctgcccct tctgtgactc tgtttccacc 3240
tagctctgag gaactccagg ctaacaaggc cacacttgtg tgcctgatct ctgacttcta 3300
ccctggggct gtgacagtgg cctggaaggc tgatagcagc ccagtgaagg ctggggttga 3360
gacaaccaca cctagcaagc agagcaacaa caaatatgct gccagcagct acctgagtct 3420
gacccctgag cagtggaagt cccacagatc ctacagctgc caagtgaccc atgagggctc 3480
tacagtggaa aagactgtgg ccccaacaga gtgcagctga agatctactt ctggctaata 3540
aaagatcaga gctctagtga tctgtgtgtt ggttttttgt gtctgcattc tagcaggagt 3600
caatgggaaa aacccattgg agccaagtac actgactcaa tagggacttt ccattgggtt 3660
ttgcccagta cataaggtca atagggggtg agtcaacagg aaagtcccat tggagccaag 3720
tacattgagt caatagggac tttccaatgg gttttgccca gtacataagg tcaatgggag 3780
gtaagccaat gggtttttcc cattactgac atgtatactg agtcattagg gactttccaa 3840
tgggttttgc ccagtacata aggtcaatag gggtgaatca acaggaaagt cccattggag 3900
ccaagtacac tgagtcaata gggactttcc attgggtttt gcccagtaca aaaggtcaat 3960
agggggtgag tcaatgggtt tttcccatta ttggcacata cataaggtca ataggggtga 4020
ctagtggaga agagcatgct tgagggctga gtgcccctca gtgggcagag agcacatggc 4080
ccacagtccc tgagaagttg gggggagggg tgggcaattg aactggtgcc tagagaaggt 4140
ggggcttggg taaactggga aagtgatgtg gtgtactggc tccacctttt tccccagggt 4200
gggggagaac catatataag tgcagtagtc tctgtgaaca ttcaagcttc tgccttctcc 4260
ctcctgtgag tttggtaagt cactgactgt ctatgcctgg gaaagggtgg gcaggagatg 4320
gggcagtgca ggaaaagtgg cactatgaac cctgcagccc tagacaattg tactaacctt 4380
cttctctttc ctctcctgac aggttggtaa ccaagccacc atgggatggt ccctgatcct 4440
gctgtttctg gtggctgtgg ccaccagagt gctgtctgaa gtgcagctgg tggaaagtgg 4500
tggtggcctg gttcagcctg gtggctctct gagactgagc tgtgctgcct ctggcttcat 4560
tgtgtccagc aactacatga gctgggtcag acaggcccct ggcaaaggac tggaatgggt 4620
gtcagtgatc tacagtggtg gcagcaccta ctatgctgac tctgtgaagg gcagattcac 4680
catcagcaga cacaacagca agaacaccct gtacctgcag atgaacagcc tgagagctga 4740
ggacactgct gtgtactact gtgccagaga agcctatggc atggatgtgt ggggccaggg 4800
cacaacagtg actgtgtcct ctgccagcac aaagggcccc tctgtgtttc ctctggctcc 4860
cagcagcaag agcaccagtg gtggaacagc tgccctgggc tgtctggtca aggactactt 4920
tcctgagcct gtgacagtgt cctggaactc tggggctctg acatctgggg tgcacacatt 4980
ccctgcagtg ctgcagtcct ctggcctgta cagcctgtcc tctgtggtca cagtgcctag 5040
ctctagcctg ggcacccaga cctacatctg caatgtgaac cacaagccta gcaacaccaa 5100
ggtggacaag aaggctgagc ccaagagctg tgacaagacc cacacctgtc ctccatgtcc 5160
tgctccagag ctgcttggag gaccatcagt gtttctgttc cctccaaagc ctaaggacac 5220
cctgatgatc agcagaaccc ctgaagtgac ctgtgtggtg gttgatgtgt cccatgagga 5280
cccagaagtg aagttcaatt ggtatgtgga tggtgttgag gtgcacaatg ccaagaccaa 5340
gcctagagag gaacagtaca actccaccta cagagtggtt tctgtgctga cagtgctcca 5400
ccaggactgg ctgaatggca aagagtacaa gtgcaaggtg tccaacaagg ccctgcctgc 5460
tcctattgaa aagaccatct ccaaggccaa gggccagcct agggaacccc aggtttacac 5520
actgccacct agcagggatg agctgaccaa gaaccaggtg tccctgacat gcctggttaa 5580
gggcttctac ccctctgaca ttgctgtgga atgggagagc aatggccagc cagagaacaa 5640
ctacaagaca acccctcctg tgctggactc tgatggctca ttcttcctgt actccaagct 5700
gactgtggac aagtccagat ggcagcaggg caatgtcttt agctgctctg tgatgcatga 5760
ggccctgcac aaccactaca cacagaagtc cctgtctctg agccctggca agagaaagag 5820
aaggagtggc tctggggcca ccaacttcag cctgctgaaa caggctgggg atgttgaaga 5880
gaaccctgga cctatggact tccaggtgca gatcatcagc tttctgctta tctctgccag 5940
tgtgatcatg agcaggggag acattgtgat gacccagtct ccatccttcc tgagtgcctc 6000
tgtgggagac agagtgacca tcacctgtag agccagccag ggcatcagct cttacctggc 6060
ttggtatcag caaaagcctg gcaaggcccc taagctgctg atctatgctg cctccacact 6120
gcagtcaggg gtgccctcca gattttctgg ctctggatct ggcactgagt tcaccctgac 6180
catcagctcc ctgcagcctg aggactttgc cacctactac tgccagcagc tgaacagcta 6240
ccctccttac acctttggac agggcaccaa gctggaaatc aagaggacag tggctgctcc 6300
ttctgtgttc atcttcccac catcagatga acagctgaag agtggcacag cctctgttgt 6360
gtgcctgctc aacaacttct accctagaga agccaaggtg cagtggaaag tggacaatgc 6420
cctccagtct ggcaacagcc aagaatctgt gactgagcag gactccaagg acagcacata 6480
cagcctgagc agcacactga ccctgagcaa ggctgactat gagaagcaca aagtctatgc 6540
ctgtgaagtg acacaccagg gcctgtctag cccagtgacc aagtccttca acaggggaga 6600
gtgttgaaga tctacttctg gctaataaaa gatcagagct ctagtgatct gtgtgttggt 6660
tttttgtgtc tgcattctag caagtcaata tgttcacccc aaaaaagctg tttgttaact 6720
tgtcaacctc attctaaaat gtatatagaa gcccaaaaga caataacaaa aatattcttg 6780
tagaacaaaa tgggaaagaa tgttccacta aatatcaaga tttagagcaa agcatgagat 6840
gtgtggggat agacagtgag gctgataaaa tagagtagag ctcagaaaca gacccattga 6900
tatatgtaag tgacctatga aaaaaatatg gcattttaca atgggaaaat gatggtcttt 6960
ttctttttta gaaaaacagg gaaatatatt tatatgtaaa aaataaaagg gaacccatat 7020
gtcataccat acacacaaaa aaattccagt gaattataag tctaaatgga gaaggcaaaa 7080
ctttaaatct tttagaaaat aatatagaag catgccatca agacttcagt gtagagaaaa 7140
atttcttatg actcaaagtc ctaaccacaa agaaaagatt gttaattaga ttgcatgaat 7200
attaagactt atttttaaaa ttaaaaaacc attaagaaaa gtcaggccat agaatgacag 7260
aaaatatttg caacacccca gtaaagagaa ttgtaatatg cagattataa aaagaagtct 7320
tacaaatcag taaaaaataa aactagacaa aaatttgaac agatgaaaga gaaactctaa 7380
ataatcatta cacatgagaa actcaatctc agaaatcaga gaactatcat tgcatataca 7440
ctaaattaga gaaatattaa aaggctaagt aacatctgtg gcttaattaa tctagctcta 7500
gtgatcagca gttcaacctg ttgatagtat gtactaagct ctcatgttta atgtactaag 7560
ctctcatgtt taatgaacta aaccctcatg gctaatgtac taagctctca tggctaatgt 7620
actaagctct catgtttcat gtactaagct ctcatgtttg aacaataaaa ttaatataaa 7680
tcagcaactt aaatagcctc taaggtttta agttttataa gaaaaaaaag aatatataag 7740
gcttttaaag gttttaaggt ttcctaggtt atcctcatat gagctcttag aaaaactcat 7800
ccagcatcaa atgaaactgc aatttattca tatcaggatt atcaatacca tatttttgaa 7860
aaagtctttt ctgtaatgaa ggagaaaact cacccaggca gttccatagg atggcaagat 7920
cctggtatct gtctgcaatt ccaactcttc caacatcaat acaacctatt aatttcccct 7980
catcaaaaat aaggttatca agtgagaaat caccatgagt gaccactgaa tctggtgaga 8040
atggcaaaag attatgcatt tctttccaga cttgttcaac aggccagcca tttctctcat 8100
catcaaaatc actggcatca accaaaccat tattcattct tgattgggcc tgagccagtc 8160
taaatactct atcagagtta aaaggacaat tacaaacagg aatggaatgc aatcttctca 8220
ggaacactgc cagggcatca acaatatttt cacctgaatc aggatattct tccaatacct 8280
ggaatgctgt tttccctggg atggcagtgg tgagtaacca tgcatcatca ggagttctga 8340
taaaatgctt gatggttgga agaggcataa attcagtcag ccagtttagt ctgaccatct 8400
catctgtaac atcattggca acagaacctt tgccatgttt cagaaacaac tctggggcat 8460
ctggcttccc atacaatcta tagattgtgg cacctgattg cccaacatta tctctagccc 8520
atttataccc atataaatca gcatccatgt tggaatttaa tcttggcctg gagcaagagg 8580
tttctctttg aatatggctc atacatgtgc acctcctata gtgagttgta ttatactatg 8640
cagatatact atgccaatgt ttaattgtca g 8671
<210> 18
<211> 8722
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic
<400> 18
cactatgtgt taattaaaat tatctctaag gcatgtgaac tggctgtctt ggttttcatc 60
tgtacttcat ctgctacctc tgtgacctga aacatattta taattccatt aagctgtgca 120
tatgatagat ttatcatatg tattttcctt aaaggatttt tgtaagaact aattgaattg 180
atacctgtaa agtctttatc acactaccca ataaataata aatctctttg ttcagctctc 240
tgtttctata aatatgtacc agttttattg tttttagtgg tagtgatttt attctctttc 300
tatatatata cacacacatg tgtgcattca taaatatata caatttttat gaataaaaaa 360
ttattagcaa tcaatattga aaaccactga tttttgttta tgtgagcaaa cagcagatta 420
aaaggaattt gaattctcat agctagcagg agtcaatggg aaaaacccat tggagccaag 480
tacactgact caatagggac tttccattgg gttttgccca gtacataagg tcaatagggg 540
gtgagtcaac aggaaagtcc cattggagcc aagtacattg agtcaatagg gactttccaa 600
tgggttttgc ccagtacata aggtcaatgg gaggtaagcc aatgggtttt tcccattact 660
gacatgtata ctgagtcatt agggactttc caatgggttt tgcccagtac ataaggtcaa 720
taggggtgaa tcaacaggaa agtcccattg gagccaagta cactgagtca atagggactt 780
tccattgggt tttgcccagt acaaaaggtc aatagggggt gagtcaatgg gtttttccca 840
ttattggcac atacataagg tcaatagggg tgactagtgg agaagagcat gcttgagggc 900
tgagtgcccc tcagtgggca gagagcacat ggcccacagt ccctgagaag ttggggggag 960
gggtgggcaa ttgaactggt gcctagagaa ggtggggctt gggtaaactg ggaaagtgat 1020
gtggtgtact ggctccacct ttttccccag ggtgggggag aaccatatat aagtgcagta 1080
gtctctgtga acattcaagc ttctgccttc tccctcctgt gagtttggta agtcactgac 1140
tgtctatgcc tgggaaaggg tgggcaggag atggggcagt gcaggaaaag tggcactatg 1200
aaccctgcag ccctagacaa ttgtactaac cttcttctct ttcctctcct gacaggttgg 1260
taaccaagcc accatgaact ttggcctgag cctgatcttc ctggtgctga tcctgaaagg 1320
ggtgcagtgt gaagtgcagc tggtggaatc tggggctgaa gtgaagaaac ctggggcctc 1380
tgtgaaggtg tcctgcaaag tgtctggcta caccctgaca gagctgagca tgcactgggt 1440
cagacaggcc cctggcaaag gccttgaatg gatgggaggc tttgaccctg aggatgggga 1500
gactatgtat gcccagaaat tccagggcag agtgaccatg acagaggaca ccagcacaga 1560
cacagcctac atggaactga gcagccttag gagtgaagat acagctgtgt actactgtgc 1620
caccagcact gctgtggctg gcacccctga cctgtttgac tactactatg gcatggatgt 1680
gtggggccag ggcaccacag tgacagtcag ctctgcttcc acaaagggcc cctctgtgtt 1740
ccctctggct cctagcagca agagcaccag tggtggaaca gctgccctgg gctgtctggt 1800
caaggactac tttcctgagc cagtgactgt gtcctggaac agtggggctc tgacatctgg 1860
ggtgcacaca ttccctgctg tgctccagtc ctctggcctg tacagcctct cctctgtggt 1920
cactgtgcca agctctagcc tgggcaccca gacctacatc tgcaatgtga accacaagcc 1980
tagcaacacc aaggtggaca agaaggctga gcccaagagc tgtgacaaga cccacacctg 2040
tcctccatgt cctgctccag agctgcttgg aggaccttct gtgtttctgt tccctccaaa 2100
gcctaaggac accctgatga tcagcagaac ccctgaagtg acctgtgtgg tggtggatgt 2160
gtcccatgag gacccagaag tgaagttcaa ttggtatgtg gatggtgttg aggtgcacaa 2220
tgccaagacc aagcctagag aggaacagta caacagcacc tacagagtgg tgtcagtgct 2280
gacagtgctg caccaggact ggctgaatgg caaagagtac aagtgcaagg tgtccaacaa 2340
ggccctgcct gctcctattg aaaagaccat cagcaaggcc aagggccagc ctagggaacc 2400
ccaagtgtat accctgccac ctagcagaga tgagctgacc aagaaccagg tgtccctgac 2460
atgcctggtt aagggcttct acccctctga cattgctgtg gaatgggaga gcaatggcca 2520
gcctgagaac aactacaaga caacccctcc tgtgctggac tctgatggct cattcttcct 2580
gtactccaag ctcacagtgg acaagtccag atggcagcaa ggcaatgtgt tcagctgctc 2640
tgtgatgcat gaggccctgc acaaccacta cacacagaag tccctgtctc tgagccctgg 2700
caagagaaag agaaggagtg gctctggggc caccaacttc agcctgctga aacaggctgg 2760
ggatgttgaa gagaaccctg gacctatggc ctgggctctg ctgctgctgg gactgctgtc 2820
tcactgcaca ggctctgtga cagagattgt gatgacacag agccctctgt ctagccctgt 2880
gacactggga cagcctgcca gcatcagctg tagaagctct cagagtctgg tgcattctga 2940
tggcaacacc tacctgagct ggctgcaaca gaggcctgga cagccaccta gactgctgat 3000
ctacaagatc agcaacaggt tctctggggt cccagacaga ttctctggaa gtggtgctgg 3060
cacagacttc actctgaaga ttagcagagt ggaagctgag gatgttgggg tgtactattg 3120
cacccaggcc acacagttcc cttacacctt tggccaggga acaaaagtgg acatcaaggg 3180
caccaaactg actgtgctgg gccagccaaa ggctgcccct tctgtgactc tgtttccacc 3240
tagctctgag gaactccagg ctaacaaggc cacacttgtg tgcctgatct ctgacttcta 3300
ccctggggct gtgacagtgg cctggaaggc tgatagcagc ccagtgaagg ctggggttga 3360
gacaaccaca cctagcaagc agagcaacaa caaatatgct gccagcagct acctgagtct 3420
gacccctgag cagtggaagt cccacagatc ctacagctgc caagtgaccc atgagggctc 3480
tacagtggaa aagactgtgg ccccaacaga gtgcagctga agatctactt ctggctaata 3540
aaagatcaga gctctagtga tctgtgtgtt ggttttttgt gtctgcattc tagcaggagt 3600
caatgggaaa aacccattgg agccaagtac actgactcaa tagggacttt ccattgggtt 3660
ttgcccagta cataaggtca atagggggtg agtcaacagg aaagtcccat tggagccaag 3720
tacattgagt caatagggac tttccaatgg gttttgccca gtacataagg tcaatgggag 3780
gtaagccaat gggtttttcc cattactgac atgtatactg agtcattagg gactttccaa 3840
tgggttttgc ccagtacata aggtcaatag gggtgaatca acaggaaagt cccattggag 3900
ccaagtacac tgagtcaata gggactttcc attgggtttt gcccagtaca aaaggtcaat 3960
agggggtgag tcaatgggtt tttcccatta ttggcacata cataaggtca ataggggtga 4020
ctagtggaga agagcatgct tgagggctga gtgcccctca gtgggcagag agcacatggc 4080
ccacagtccc tgagaagttg gggggagggg tgggcaattg aactggtgcc tagagaaggt 4140
ggggcttggg taaactggga aagtgatgtg gtgtactggc tccacctttt tccccagggt 4200
gggggagaac catatataag tgcagtagtc tctgtgaaca ttcaagcttc tgccttctcc 4260
ctcctgtgag tttggtaagt cactgactgt ctatgcctgg gaaagggtgg gcaggagatg 4320
gggcagtgca ggaaaagtgg cactatgaac cctgcagccc tagacaattg tactaacctt 4380
cttctctttc ctctcctgac aggttggtaa ccaagccacc atgggatggt ccctgatcct 4440
gctgtttctg gtggctgtgg ccaccagagt gctgtctcag gttcagctgg tgcagtctgg 4500
ggctgaagtg aagaaacctg gggcctctgt gaaggtgtcc tgcaaggctt ctggctacac 4560
attcacaggc tactacatgc actgggtcag acaggcccct ggacagggac ttgagtggat 4620
gggcagaatc aaccccaaca gtggtggcac caactatgcc cagaaattcc agggcagagt 4680
gaccatgacc agagacacca gcatcagcac agcctacatg gaactgagca ggcttaggag 4740
tgatgacact gctgtgtact actgtgccag agtgccctac tgcagcagca cctcttgtca 4800
cagagactgg tactttgacc tgtggggcag aggcaccctg gtcacagtta gctctgccag 4860
cacaaagggc ccctctgtgt ttcctctggc tcccagcagc aagagcacca gtggtggaac 4920
agctgccctg ggctgtctgg tcaaggacta ctttcctgag cctgtgacag tgtcctggaa 4980
ctctggggct ctgacatctg gggtgcacac attccctgct gtgctgcagt cctctggcct 5040
gtacagcctg tcctctgtgg tcactgtgcc tagctctagc ctgggcaccc agacctacat 5100
ctgcaatgtg aaccacaagc ctagcaacac caaggtggac aagaaggctg agcccaagag 5160
ctgtgataag acccacacct gtcctccatg tcctgctcca gagctgcttg gaggaccatc 5220
agtgtttctg ttccctccaa agcctaagga caccctgatg atcagcagaa cccctgaagt 5280
gacctgtgtg gtggtggatg tgtcccatga ggacccagaa gtgaagttca attggtatgt 5340
ggatggtgtt gaggtgcaca atgccaagac caagcctaga gaggaacagt acaacagcac 5400
ctacagagtg gtgtctgtgc tgacagtgct gcaccaggac tggctgaatg gcaaagagta 5460
caagtgcaag gtgtccaaca aggccctgcc tgctcctatt gaaaagacca tcagcaaggc 5520
caagggccag cctagggaac cccaagtgta taccctgcct cctagcagag atgagctgac 5580
caagaaccag gtgtccctga catgcctggt taagggcttc tacccctctg acattgctgt 5640
ggaatgggag agcaatggcc agcctgagaa caactacaag accacacctc ctgtgctgga 5700
ctctgatggc tcattcttcc tgtactccaa gctgactgtg gacaagtcca gatggcagca 5760
aggcaatgtg ttcagctgct ctgtgatgca tgaggccctg cacaaccact acacacagaa 5820
gtctctgtct ctgagccctg gcaagagaaa gagaaggagt ggctctgggg ccaccaactt 5880
cagcctgctg aaacaggctg gggatgttga agagaaccct ggacctatgg acttccaggt 5940
gcagatcatc agctttctgc ttatctctgc cagtgtgatc atgagcaggg gagacatcca 6000
gatgacacag agccctctga gcctgccagt gacacctggg gaacctgcca gcatctcttg 6060
cagaagctct cagagcctcc tggattctga tgatggcaac acctacctgg actggtatct 6120
gcagaagcct ggccagtctc ctcagctgct gatctacacc ctgagctaca gagccagtgg 6180
ggtgccagac agattctctg gctctggatc tggcactgac ttcacactga agattagcag 6240
agtggaagct gaggatgtgg gagtctacta ctgtatgcag aggattgagt tccctctgac 6300
ttttggtggt ggtacaaagg tggaaatcaa gaggacagtg gctgctcctt ctgtgttcat 6360
cttcccacca tctgatgagc agctcaagag tggcacagcc tctgttgtgt gtctgctgaa 6420
caacttctac cctagggaag ccaaggtgca gtggaaagtg gacaatgccc tccagtctgg 6480
caacagccaa gagagtgtga cagaacagga cagcaaggac tccacctaca gcctgagcag 6540
caccctgaca ctgagcaagg ctgactatga gaagcacaaa gtctatgcct gtgaagtgac 6600
acaccaggga ctgagcagcc ctgtgaccaa gagcttcaac aggggagagt gcagctgaag 6660
atctacttct ggctaataaa agatcagagc tctagtgatc tgtgtgttgg ttttttgtgt 6720
ctgcattcta gcaagtcaat atgttcaccc caaaaaagct gtttgttaac ttgtcaacct 6780
cattctaaaa tgtatataga agcccaaaag acaataacaa aaatattctt gtagaacaaa 6840
atgggaaaga atgttccact aaatatcaag atttagagca aagcatgaga tgtgtgggga 6900
tagacagtga ggctgataaa atagagtaga gctcagaaac agacccattg atatatgtaa 6960
gtgacctatg aaaaaaatat ggcattttac aatgggaaaa tgatggtctt tttctttttt 7020
agaaaaacag ggaaatatat ttatatgtaa aaaataaaag ggaacccata tgtcatacca 7080
tacacacaaa aaaattccag tgaattataa gtctaaatgg agaaggcaaa actttaaatc 7140
ttttagaaaa taatatagaa gcatgccatc aagacttcag tgtagagaaa aatttcttat 7200
gactcaaagt cctaaccaca aagaaaagat tgttaattag attgcatgaa tattaagact 7260
tatttttaaa attaaaaaac cattaagaaa agtcaggcca tagaatgaca gaaaatattt 7320
gcaacacccc agtaaagaga attgtaatat gcagattata aaaagaagtc ttacaaatca 7380
gtaaaaaata aaactagaca aaaatttgaa cagatgaaag agaaactcta aataatcatt 7440
acacatgaga aactcaatct cagaaatcag agaactatca ttgcatatac actaaattag 7500
agaaatatta aaaggctaag taacatctgt ggcttaatta atctagctct agtgatcagc 7560
agttcaacct gttgatagta tgtactaagc tctcatgttt aatgtactaa gctctcatgt 7620
ttaatgaact aaaccctcat ggctaatgta ctaagctctc atggctaatg tactaagctc 7680
tcatgtttca tgtactaagc tctcatgttt gaacaataaa attaatataa atcagcaact 7740
taaatagcct ctaaggtttt aagttttata agaaaaaaaa gaatatataa ggcttttaaa 7800
ggttttaagg tttcctaggt tatcctcata tgagctctta gaaaaactca tccagcatca 7860
aatgaaactg caatttattc atatcaggat tatcaatacc atatttttga aaaagtcttt 7920
tctgtaatga aggagaaaac tcacccaggc agttccatag gatggcaaga tcctggtatc 7980
tgtctgcaat tccaactctt ccaacatcaa tacaacctat taatttcccc tcatcaaaaa 8040
taaggttatc aagtgagaaa tcaccatgag tgaccactga atctggtgag aatggcaaaa 8100
gattatgcat ttctttccag acttgttcaa caggccagcc atttctctca tcatcaaaat 8160
cactggcatc aaccaaacca ttattcattc ttgattgggc ctgagccagt ctaaatactc 8220
tatcagagtt aaaaggacaa ttacaaacag gaatggaatg caatcttctc aggaacactg 8280
ccagggcatc aacaatattt tcacctgaat caggatattc ttccaatacc tggaatgctg 8340
ttttccctgg gatggcagtg gtgagtaacc atgcatcatc aggagttctg ataaaatgct 8400
tgatggttgg aagaggcata aattcagtca gccagtttag tctgaccatc tcatctgtaa 8460
catcattggc aacagaacct ttgccatgtt tcagaaacaa ctctggggca tctggcttcc 8520
catacaatct atagattgtg gcacctgatt gcccaacatt atctctagcc catttatacc 8580
catataaatc agcatccatg ttggaattta atcttggcct ggagcaagag gtttctcttt 8640
gaatatggct catacatgtg cacctcctat agtgagttgt attatactat gcagatatac 8700
tatgccaatg tttaattgtc ag 8722
<210> 19
<211> 8707
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic
<400> 19
cactatgtgt taattaaaat tatctctaag gcatgtgaac tggctgtctt ggttttcatc 60
tgtacttcat ctgctacctc tgtgacctga aacatattta taattccatt aagctgtgca 120
tatgatagat ttatcatatg tattttcctt aaaggatttt tgtaagaact aattgaattg 180
atacctgtaa agtctttatc acactaccca ataaataata aatctctttg ttcagctctc 240
tgtttctata aatatgtacc agttttattg tttttagtgg tagtgatttt attctctttc 300
tatatatata cacacacatg tgtgcattca taaatatata caatttttat gaataaaaaa 360
ttattagcaa tcaatattga aaaccactga tttttgttta tgtgagcaaa cagcagatta 420
aaaggaattt gaattctcat agctagcagg agtcaatggg aaaaacccat tggagccaag 480
tacactgact caatagggac tttccattgg gttttgccca gtacataagg tcaatagggg 540
gtgagtcaac aggaaagtcc cattggagcc aagtacattg agtcaatagg gactttccaa 600
tgggttttgc ccagtacata aggtcaatgg gaggtaagcc aatgggtttt tcccattact 660
gacatgtata ctgagtcatt agggactttc caatgggttt tgcccagtac ataaggtcaa 720
taggggtgaa tcaacaggaa agtcccattg gagccaagta cactgagtca atagggactt 780
tccattgggt tttgcccagt acaaaaggtc aatagggggt gagtcaatgg gtttttccca 840
ttattggcac atacataagg tcaatagggg tgactagtgg agaagagcat gcttgagggc 900
tgagtgcccc tcagtgggca gagagcacat ggcccacagt ccctgagaag ttggggggag 960
gggtgggcaa ttgaactggt gcctagagaa ggtggggctt gggtaaactg ggaaagtgat 1020
gtggtgtact ggctccacct ttttccccag ggtgggggag aaccatatat aagtgcagta 1080
gtctctgtga acattcaagc ttctgccttc tccctcctgt gagtttggta agtcactgac 1140
tgtctatgcc tgggaaaggg tgggcaggag atggggcagt gcaggaaaag tggcactatg 1200
aaccctgcag ccctagacaa ttgtactaac cttcttctct ttcctctcct gacaggttgg 1260
taaccaagcc accatgaact ttggcctgag cctgatcttc ctggtgctga tcctgaaagg 1320
ggtgcagtgt gaagtgcagc tggtggaatc tggggctgaa gtgaagaaac ctggggcctc 1380
tgtgaaggtg tcctgcaaag tgtctggcta caccctgaca gagctgagca tgcactgggt 1440
cagacaggcc cctggcaaag gccttgaatg gatgggaggc tttgaccctg aggatgggga 1500
gactatgtat gcccagaaat tccagggcag agtgaccatg acagaggaca ccagcacaga 1560
cacagcctac atggaactga gcagccttag gagtgaagat acagctgtgt actactgtgc 1620
caccagcact gctgtggctg gcacccctga cctgtttgac tactactatg gcatggatgt 1680
gtggggccag ggcaccacag tgacagtcag ctctgcttcc acaaagggcc cctctgtgtt 1740
ccctctggct cctagcagca agagcaccag tggtggaaca gctgccctgg gctgtctggt 1800
caaggactac tttcctgagc cagtgactgt gtcctggaac agtggggctc tgacatctgg 1860
ggtgcacaca ttccctgctg tgctccagtc ctctggcctg tacagcctct cctctgtggt 1920
cactgtgcca agctctagcc tgggcaccca gacctacatc tgcaatgtga accacaagcc 1980
tagcaacacc aaggtggaca agaaggctga gcccaagagc tgtgacaaga cccacacctg 2040
tcctccatgt cctgctccag agctgcttgg aggaccttct gtgtttctgt tccctccaaa 2100
gcctaaggac accctgatga tcagcagaac ccctgaagtg acctgtgtgg tggtggatgt 2160
gtcccatgag gacccagaag tgaagttcaa ttggtatgtg gatggtgttg aggtgcacaa 2220
tgccaagacc aagcctagag aggaacagta caacagcacc tacagagtgg tgtcagtgct 2280
gacagtgctg caccaggact ggctgaatgg caaagagtac aagtgcaagg tgtccaacaa 2340
ggccctgcct gctcctattg aaaagaccat cagcaaggcc aagggccagc ctagggaacc 2400
ccaagtgtat accctgccac ctagcagaga tgagctgacc aagaaccagg tgtccctgac 2460
atgcctggtt aagggcttct acccctctga cattgctgtg gaatgggaga gcaatggcca 2520
gcctgagaac aactacaaga caacccctcc tgtgctggac tctgatggct cattcttcct 2580
gtactccaag ctcacagtgg acaagtccag atggcagcaa ggcaatgtgt tcagctgctc 2640
tgtgatgcat gaggccctgc acaaccacta cacacagaag tccctgtctc tgagccctgg 2700
caagagaaag agaaggagtg gctctggggc caccaacttc agcctgctga aacaggctgg 2760
ggatgttgaa gagaaccctg gacctatggc ctgggctctg ctgctgctgg gactgctgtc 2820
tcactgcaca ggctctgtga cagagattgt gatgacacag agccctctgt ctagccctgt 2880
gacactggga cagcctgcca gcatcagctg tagaagctct cagagtctgg tgcattctga 2940
tggcaacacc tacctgagct ggctgcaaca gaggcctgga cagccaccta gactgctgat 3000
ctacaagatc agcaacaggt tctctggggt cccagacaga ttctctggaa gtggtgctgg 3060
cacagacttc actctgaaga ttagcagagt ggaagctgag gatgttgggg tgtactattg 3120
cacccaggcc acacagttcc cttacacctt tggccaggga acaaaagtgg acatcaaggg 3180
caccaaactg actgtgctgg gccagccaaa ggctgcccct tctgtgactc tgtttccacc 3240
tagctctgag gaactccagg ctaacaaggc cacacttgtg tgcctgatct ctgacttcta 3300
ccctggggct gtgacagtgg cctggaaggc tgatagcagc ccagtgaagg ctggggttga 3360
gacaaccaca cctagcaagc agagcaacaa caaatatgct gccagcagct acctgagtct 3420
gacccctgag cagtggaagt cccacagatc ctacagctgc caagtgaccc atgagggctc 3480
tacagtggaa aagactgtgg ccccaacaga gtgcagctga agatctactt ctggctaata 3540
aaagatcaga gctctagtga tctgtgtgtt ggttttttgt gtctgcattc tagcaggagt 3600
caatgggaaa aacccattgg agccaagtac actgactcaa tagggacttt ccattgggtt 3660
ttgcccagta cataaggtca atagggggtg agtcaacagg aaagtcccat tggagccaag 3720
tacattgagt caatagggac tttccaatgg gttttgccca gtacataagg tcaatgggag 3780
gtaagccaat gggtttttcc cattactgac atgtatactg agtcattagg gactttccaa 3840
tgggttttgc ccagtacata aggtcaatag gggtgaatca acaggaaagt cccattggag 3900
ccaagtacac tgagtcaata gggactttcc attgggtttt gcccagtaca aaaggtcaat 3960
agggggtgag tcaatgggtt tttcccatta ttggcacata cataaggtca ataggggtga 4020
ctagtggaga agagcatgct tgagggctga gtgcccctca gtgggcagag agcacatggc 4080
ccacagtccc tgagaagttg gggggagggg tgggcaattg aactggtgcc tagagaaggt 4140
ggggcttggg taaactggga aagtgatgtg gtgtactggc tccacctttt tccccagggt 4200
gggggagaac catatataag tgcagtagtc tctgtgaaca ttcaagcttc tgccttctcc 4260
ctcctgtgag tttggtaagt cactgactgt ctatgcctgg gaaagggtgg gcaggagatg 4320
gggcagtgca ggaaaagtgg cactatgaac cctgcagccc tagacaattg tactaacctt 4380
cttctctttc ctctcctgac aggttggtaa ccaagccacc atgagcagca gctcttggct 4440
gctgctgagt ctggtggctg tgacagctgc ccagagcacc attgaggaac aggccaagac 4500
cttcctggac aagttcaacc atgaggctga ggacctgttc taccagagca gcctggccag 4560
ctggaactac aacaccaaca tcactgaaga gaatgtgcag aacatgaaca atgctgggga 4620
caagtggagt gccttcctga aagagcagag cacactggcc cagatgtacc ctctgcaaga 4680
gatccagaac ctgacagtga agctccagct ccaggctctc cagcagaatg gcagctctgt 4740
gctgtctgag gacaagagca agagactgaa caccatcctg aacacaatga gcaccatcta 4800
cagcacaggc aaagtgtgca accctgacaa ccctcaagag tgcctgctgc tggaacctgg 4860
cctgaatgag atcatggcca acagcctgga ctacaatgag agactgtggg cctgggagtc 4920
ttggaggagt gaagtgggaa agcagctgag gcccctgtat gaggaatatg tggtgctgaa 4980
gaatgagatg gccagggcca accactatga ggactatggg gattattgga ggggagacta 5040
tgaagtgaat ggtgttgatg gctatgacta cagcaggggc cagctgattg aggatgtgga 5100
acacaccttt gaggaaatca agcccctcta tgagcacctc catgcctatg tcagagccaa 5160
gctgatgaat gcttacccca gctacatcag ccccattggc tgcctgcctg ctcatctgct 5220
gggagacatg tggggcagat tctggaccaa cctgtacagc ctgactgtgc cctttggcca 5280
gaaacctaac attgatgtga cagatgccat ggtggatcag gcctgggatg cccagagaat 5340
cttcaaagag gctgagaagt tctttgtgtc tgtggggctg cccaacatga cccaaggctt 5400
ttgggagaac tccatgctga cagaccctgg caatgtgcaa aaggctgtgt gtcaccccac 5460
agcctgggac cttggcaagg gagacttcag aatcctgatg tgcaccaaag tgacaatgga 5520
tgactttctg acagctcacc atgagatggg ccacatccag tatgacatgg cctatgctgc 5580
ccagcctttc ctgctgagaa atggggccaa tgagggcttc catgaggcag tgggagagat 5640
catgagcctg tctgctgcca cacctaagca cctgaagtcc attggcctgc tgagccctga 5700
cttccaagag gacaatgaga cagagatcaa cttcctgctc aagcaggccc tgaccattgt 5760
gggcacactg cccttcacct acatgctgga aaagtggaga tggatggtct ttaagggaga 5820
aatccccaag gaccagtgga tgaagaaatg gtgggagatg aagagggaaa ttgtgggagt 5880
tgtggaacct gtgccacatg atgagacata ctgtgaccct gccagcctgt tccatgtgtc 5940
caatgactac tccttcatta ggtactacac caggacactg taccagttcc agtttcaaga 6000
ggctctgtgt caggctgcta aacatgaggg cccactgcac aagtgtgaca tcagcaactc 6060
cacagaggct ggacagaaac tgttcaacat gctgagactg ggcaagtctg agccttggac 6120
tctggccctg gaaaatgttg tgggagccaa gaatatgaat gtcagacccc tgctgaacta 6180
ctttgagccc ctgttcacct ggctgaagga ccagaacaag aacagctttg ttggctggtc 6240
cacagactgg tccccatatg ctgaccagag catcaaagtc agaatcagcc tgaagagtgc 6300
cctgggagat aaggcctatg agtggaatga taatgagatg tacctgttca ggtcctctgt 6360
ggcttatgct atgagacagt actttctgaa agtgaagaac cagatgatcc tgtttggaga 6420
agaggatgtc agagtggcca acctgaagcc tagaatcagc ttcaacttct ttgtgacagc 6480
ccctaagaat gtgtctgaca tcatccccag aacagaggtg gaaaaggcca tcagaatgag 6540
caggtccagg atcaatgatg ccttcaggct caatgacaac tccctggaat ttctgggcat 6600
tcagcccaca ctgggccctc caaatcagcc tcctgtgtcc taaagatcta cttctggcta 6660
ataaaagatc agagctctag tgatctgtgt gttggttttt tgtgtctgca ttctagcaag 6720
tcaatatgtt caccccaaaa aagctgtttg ttaacttgtc aacctcattc taaaatgtat 6780
atagaagccc aaaagacaat aacaaaaata ttcttgtaga acaaaatggg aaagaatgtt 6840
ccactaaata tcaagattta gagcaaagca tgagatgtgt ggggatagac agtgaggctg 6900
ataaaataga gtagagctca gaaacagacc cattgatata tgtaagtgac ctatgaaaaa 6960
aatatggcat tttacaatgg gaaaatgatg gtctttttct tttttagaaa aacagggaaa 7020
tatatttata tgtaaaaaat aaaagggaac ccatatgtca taccatacac acaaaaaaat 7080
tccagtgaat tataagtcta aatggagaag gcaaaacttt aaatctttta gaaaataata 7140
tagaagcatg ccatcaagac ttcagtgtag agaaaaattt cttatgactc aaagtcctaa 7200
ccacaaagaa aagattgtta attagattgc atgaatatta agacttattt ttaaaattaa 7260
aaaaccatta agaaaagtca ggccatagaa tgacagaaaa tatttgcaac accccagtaa 7320
agagaattgt aatatgcaga ttataaaaag aagtcttaca aatcagtaaa aaataaaact 7380
agacaaaaat ttgaacagat gaaagagaaa ctctaaataa tcattacaca tgagaaactc 7440
aatctcagaa atcagagaac tatcattgca tatacactaa attagagaaa tattaaaagg 7500
ctaagtaaca tctgtggctt aattaatcta gctctagtga tcagcagttc aacctgttga 7560
tagtatgtac taagctctca tgtttaatgt actaagctct catgtttaat gaactaaacc 7620
ctcatggcta atgtactaag ctctcatggc taatgtacta agctctcatg tttcatgtac 7680
taagctctca tgtttgaaca ataaaattaa tataaatcag caacttaaat agcctctaag 7740
gttttaagtt ttataagaaa aaaaagaata tataaggctt ttaaaggttt taaggtttcc 7800
taggttatcc tcatatgagc tcttagaaaa actcatccag catcaaatga aactgcaatt 7860
tattcatatc aggattatca ataccatatt tttgaaaaag tcttttctgt aatgaaggag 7920
aaaactcacc caggcagttc cataggatgg caagatcctg gtatctgtct gcaattccaa 7980
ctcttccaac atcaatacaa cctattaatt tcccctcatc aaaaataagg ttatcaagtg 8040
agaaatcacc atgagtgacc actgaatctg gtgagaatgg caaaagatta tgcatttctt 8100
tccagacttg ttcaacaggc cagccatttc tctcatcatc aaaatcactg gcatcaacca 8160
aaccattatt cattcttgat tgggcctgag ccagtctaaa tactctatca gagttaaaag 8220
gacaattaca aacaggaatg gaatgcaatc ttctcaggaa cactgccagg gcatcaacaa 8280
tattttcacc tgaatcagga tattcttcca atacctggaa tgctgttttc cctgggatgg 8340
cagtggtgag taaccatgca tcatcaggag ttctgataaa atgcttgatg gttggaagag 8400
gcataaattc agtcagccag tttagtctga ccatctcatc tgtaacatca ttggcaacag 8460
aacctttgcc atgtttcaga aacaactctg gggcatctgg cttcccatac aatctataga 8520
ttgtggcacc tgattgccca acattatctc tagcccattt atacccatat aaatcagcat 8580
ccatgttgga atttaatctt ggcctggagc aagaggtttc tctttgaata tggctcatac 8640
atgtgcacct cctatagtga gttgtattat actatgcaga tatactatgc caatgtttaa 8700
ttgtcag 8707
<210> 20
<211> 5560
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic
<400> 20
cactatgtgt taattaaaat tatctctaag gcatgtgaac tggctgtctt ggttttcatc 60
tgtacttcat ctgctacctc tgtgacctga aacatattta taattccatt aagctgtgca 120
tatgatagat ttatcatatg tattttcctt aaaggatttt tgtaagaact aattgaattg 180
atacctgtaa agtctttatc acactaccca ataaataata aatctctttg ttcagctctc 240
tgtttctata aatatgtacc agttttattg tttttagtgg tagtgatttt attctctttc 300
tatatatata cacacacatg tgtgcattca taaatatata caatttttat gaataaaaaa 360
ttattagcaa tcaatattga aaaccactga tttttgttta tgtgagcaaa cagcagatta 420
aaaggaattt gaattctcat agctagcagg agtcaatggg aaaaacccat tggagccaag 480
tacactgact caatagggac tttccattgg gttttgccca gtacataagg tcaatagggg 540
gtgagtcaac aggaaagtcc cattggagcc aagtacattg agtcaatagg gactttccaa 600
tgggttttgc ccagtacata aggtcaatgg gaggtaagcc aatgggtttt tcccattact 660
gacatgtata ctgagtcatt agggactttc caatgggttt tgcccagtac ataaggtcaa 720
taggggtgaa tcaacaggaa agtcccattg gagccaagta cactgagtca atagggactt 780
tccattgggt tttgcccagt acaaaaggtc aatagggggt gagtcaatgg gtttttccca 840
ttattggcac atacataagg tcaatagggg tgactagtgg agaagagcat gcttgagggc 900
tgagtgcccc tcagtgggca gagagcacat ggcccacagt ccctgagaag ttggggggag 960
gggtgggcaa ttgaactggt gcctagagaa ggtggggctt gggtaaactg ggaaagtgat 1020
gtggtgtact ggctccacct ttttccccag ggtgggggag aaccatatat aagtgcagta 1080
gtctctgtga acattcaagc ttctgccttc tccctcctgt gagtttggta agtcactgac 1140
tgtctatgcc tgggaaaggg tgggcaggag atggggcagt gcaggaaaag tggcactatg 1200
aaccctgcag ccctagacaa ttgtactaac cttcttctct ttcctctcct gacaggttgg 1260
taaccaagcc accatgagca gcagctcttg gctgctgctg agtctggtgg ctgtgacagc 1320
tgcccagagc accattgagg aacaggccaa gaccttcctg gacaagttca accatgaggc 1380
tgaggacctg ttctaccaga gcagcctggc cagctggaac tacaacacca acatcactga 1440
agagaatgtg cagaacatga acaatgctgg ggacaagtgg agtgccttcc tgaaagagca 1500
gagcacactg gcccagatgt accctctgca agagatccag aacctgacag tgaagctcca 1560
gctccaggct ctccagcaga atggcagctc tgtgctgtct gaggacaaga gcaagagact 1620
gaacaccatc ctgaacacaa tgagcaccat ctacagcaca ggcaaagtgt gcaaccctga 1680
caaccctcaa gagtgcctgc tgctggaacc tggcctgaat gagatcatgg ccaacagcct 1740
ggactacaat gagagactgt gggcctggga gtcttggagg agtgaagtgg gaaagcagct 1800
gaggcccctg tatgaggaat atgtggtgct gaagaatgag atggccaggg ccaaccacta 1860
tgaggactat ggggattatt ggaggggaga ctatgaagtg aatggtgttg atggctatga 1920
ctacagcagg ggccagctga ttgaggatgt ggaacacacc tttgaggaaa tcaagcccct 1980
ctatgagcac ctccatgcct atgtcagagc caagctgatg aatgcttacc ccagctacat 2040
cagccccatt ggctgcctgc ctgctcatct gctgggagac atgtggggca gattctggac 2100
caacctgtac agcctgactg tgccctttgg ccagaaacct aacattgatg tgacagatgc 2160
catggtggat caggcctggg atgcccagag aatcttcaaa gaggctgaga agttctttgt 2220
gtctgtgggg ctgcccaaca tgacccaagg cttttgggag aactccatgc tgacagaccc 2280
tggcaatgtg caaaaggctg tgtgtcaccc cacagcctgg gaccttggca agggagactt 2340
cagaatcctg atgtgcacca aagtgacaat ggatgacttt ctgacagctc accatgagat 2400
gggccacatc cagtatgaca tggcctatgc tgcccagcct ttcctgctga gaaatggggc 2460
caatgagggc ttccatgagg cagtgggaga gatcatgagc ctgtctgctg ccacacctaa 2520
gcacctgaag tccattggcc tgctgagccc tgacttccaa gaggacaatg agacagagat 2580
caacttcctg ctcaagcagg ccctgaccat tgtgggcaca ctgcccttca cctacatgct 2640
ggaaaagtgg agatggatgg tctttaaggg agaaatcccc aaggaccagt ggatgaagaa 2700
atggtgggag atgaagaggg aaattgtggg agttgtggaa cctgtgccac atgatgagac 2760
atactgtgac cctgccagcc tgttccatgt gtccaatgac tactccttca ttaggtacta 2820
caccaggaca ctgtaccagt tccagtttca agaggctctg tgtcaggctg ctaaacatga 2880
gggcccactg cacaagtgtg acatcagcaa ctccacagag gctggacaga aactgttcaa 2940
catgctgaga ctgggcaagt ctgagccttg gactctggcc ctggaaaatg ttgtgggagc 3000
caagaatatg aatgtcagac ccctgctgaa ctactttgag cccctgttca cctggctgaa 3060
ggaccagaac aagaacagct ttgttggctg gtccacagac tggtccccat atgctgacca 3120
gagcatcaaa gtcagaatca gcctgaagag tgccctggga gataaggcct atgagtggaa 3180
tgataatgag atgtacctgt tcaggtcctc tgtggcttat gctatgagac agtactttct 3240
gaaagtgaag aaccagatga tcctgtttgg agaagaggat gtcagagtgg ccaacctgaa 3300
gcctagaatc agcttcaact tctttgtgac agcccctaag aatgtgtctg acatcatccc 3360
cagaacagag gtggaaaagg ccatcagaat gagcaggtcc aggatcaatg atgccttcag 3420
gctcaatgac aactccctgg aatttctggg cattcagccc acactgggcc ctccaaatca 3480
gcctcctgtg tcctaaagat ctacttctgg ctaataaaag atcagagctc tagtgatctg 3540
tgtgttggtt ttttgtgtct gcattctagc aagtcaatat gttcacccca aaaaagctgt 3600
ttgttaactt gtcaacctca ttctaaaatg tatatagaag cccaaaagac aataacaaaa 3660
atattcttgt agaacaaaat gggaaagaat gttccactaa atatcaagat ttagagcaaa 3720
gcatgagatg tgtggggata gacagtgagg ctgataaaat agagtagagc tcagaaacag 3780
acccattgat atatgtaagt gacctatgaa aaaaatatgg cattttacaa tgggaaaatg 3840
atggtctttt tcttttttag aaaaacaggg aaatatattt atatgtaaaa aataaaaggg 3900
aacccatatg tcataccata cacacaaaaa aattccagtg aattataagt ctaaatggag 3960
aaggcaaaac tttaaatctt ttagaaaata atatagaagc atgccatcaa gacttcagtg 4020
tagagaaaaa tttcttatga ctcaaagtcc taaccacaaa gaaaagattg ttaattagat 4080
tgcatgaata ttaagactta tttttaaaat taaaaaacca ttaagaaaag tcaggccata 4140
gaatgacaga aaatatttgc aacaccccag taaagagaat tgtaatatgc agattataaa 4200
aagaagtctt acaaatcagt aaaaaataaa actagacaaa aatttgaaca gatgaaagag 4260
aaactctaaa taatcattac acatgagaaa ctcaatctca gaaatcagag aactatcatt 4320
gcatatacac taaattagag aaatattaaa aggctaagta acatctgtgg cttaattaat 4380
ctagctctag tgatcagcag ttcaacctgt tgatagtatg tactaagctc tcatgtttaa 4440
tgtactaagc tctcatgttt aatgaactaa accctcatgg ctaatgtact aagctctcat 4500
ggctaatgta ctaagctctc atgtttcatg tactaagctc tcatgtttga acaataaaat 4560
taatataaat cagcaactta aatagcctct aaggttttaa gttttataag aaaaaaaaga 4620
atatataagg cttttaaagg ttttaaggtt tcctaggtta tcctcatatg agctcttaga 4680
aaaactcatc cagcatcaaa tgaaactgca atttattcat atcaggatta tcaataccat 4740
atttttgaaa aagtcttttc tgtaatgaag gagaaaactc acccaggcag ttccatagga 4800
tggcaagatc ctggtatctg tctgcaattc caactcttcc aacatcaata caacctatta 4860
atttcccctc atcaaaaata aggttatcaa gtgagaaatc accatgagtg accactgaat 4920
ctggtgagaa tggcaaaaga ttatgcattt ctttccagac ttgttcaaca ggccagccat 4980
ttctctcatc atcaaaatca ctggcatcaa ccaaaccatt attcattctt gattgggcct 5040
gagccagtct aaatactcta tcagagttaa aaggacaatt acaaacagga atggaatgca 5100
atcttctcag gaacactgcc agggcatcaa caatattttc acctgaatca ggatattctt 5160
ccaatacctg gaatgctgtt ttccctggga tggcagtggt gagtaaccat gcatcatcag 5220
gagttctgat aaaatgcttg atggttggaa gaggcataaa ttcagtcagc cagtttagtc 5280
tgaccatctc atctgtaaca tcattggcaa cagaaccttt gccatgtttc agaaacaact 5340
ctggggcatc tggcttccca tacaatctat agattgtggc acctgattgc ccaacattat 5400
ctctagccca tttataccca tataaatcag catccatgtt ggaatttaat cttggcctgg 5460
agcaagaggt ttctctttga atatggctca tacatgtgca cctcctatag tgagttgtat 5520
tatactatgc agatatacta tgccaatgtt taattgtcag 5560
<210> 21
<211> 5560
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic
<400> 21
cactatgtgt taattaaaat tatctctaag gcatgtgaac tggctgtctt ggttttcatc 60
tgtacttcat ctgctacctc tgtgacctga aacatattta taattccatt aagctgtgca 120
tatgatagat ttatcatatg tattttcctt aaaggatttt tgtaagaact aattgaattg 180
atacctgtaa agtctttatc acactaccca ataaataata aatctctttg ttcagctctc 240
tgtttctata aatatgtacc agttttattg tttttagtgg tagtgatttt attctctttc 300
tatatatata cacacacatg tgtgcattca taaatatata caatttttat gaataaaaaa 360
ttattagcaa tcaatattga aaaccactga tttttgttta tgtgagcaaa cagcagatta 420
aaaggaattt gaattctcat agctagcagg agtcaatggg aaaaacccat tggagccaag 480
tacactgact caatagggac tttccattgg gttttgccca gtacataagg tcaatagggg 540
gtgagtcaac aggaaagtcc cattggagcc aagtacattg agtcaatagg gactttccaa 600
tgggttttgc ccagtacata aggtcaatgg gaggtaagcc aatgggtttt tcccattact 660
gacatgtata ctgagtcatt agggactttc caatgggttt tgcccagtac ataaggtcaa 720
taggggtgaa tcaacaggaa agtcccattg gagccaagta cactgagtca atagggactt 780
tccattgggt tttgcccagt acaaaaggtc aatagggggt gagtcaatgg gtttttccca 840
ttattggcac atacataagg tcaatagggg tgactagtgg agaagagcat gcttgagggc 900
tgagtgcccc tcagtgggca gagagcacat ggcccacagt ccctgagaag ttggggggag 960
gggtgggcaa ttgaactggt gcctagagaa ggtggggctt gggtaaactg ggaaagtgat 1020
gtggtgtact ggctccacct ttttccccag ggtgggggag aaccatatat aagtgcagta 1080
gtctctgtga acattcaagc ttctgccttc tccctcctgt gagtttggta agtcactgac 1140
tgtctatgcc tgggaaaggg tgggcaggag atggggcagt gcaggaaaag tggcactatg 1200
aaccctgcag ccctagacaa ttgtactaac cttcttctct ttcctctcct gacaggttgg 1260
taaccaagcc accatgagca gcagctcttg gctgctgctg agtctggtgg ctgtgacagc 1320
tgcccagagc accattgagg aacaggccaa gtacttcctg gacaagttca accatgaggc 1380
tgaggacctg ttctaccaga gcagcctggc cagctggaac tacaacacca acatcactga 1440
agagaatgtg cagaacatga acaatgctgg ggacaagtgg agtgccttcc tgaaagagca 1500
gagcacaact gcccagatgt accctctgca agagatccag aacctgacag tgaagctcca 1560
gctccaggct ctccagcaga atggcagctc tgtgctgtct gaggacaaga gcaagagact 1620
gaacaccatc ctgaacacaa tgagcaccat ctacagcaca ggcaaagtgt gcaaccctga 1680
caaccctcaa gagtgcctgc tgctggaacc tggcctgaat gagatcatgg ccaacagcct 1740
ggactacaat gagagactgt gggcctggga gtcttggagg agtgaagtgg gaaagcagct 1800
gaggcccctg tatgaggaat atgtggtgct gaagaatgag atggccaggg ccaaccacta 1860
tgaggactat ggggattatt ggaggggaga ctatgaagtg aatggtgttg atggctatga 1920
ctacagcagg ggccagctga ttgaggatgt ggaacacacc tttgaggaaa tcaagcccct 1980
ctatgagcac ctccatgcct atgtcagagc caagctgatg aatgcttacc ccagctacat 2040
cagccccatt ggctgcctgc ctgctcatct gctgggagac atgtggggca gattctggac 2100
caacctgtac agcctgactg tgccctttgg ccagaaacct aacattgatg tgacagatgc 2160
catggtggat caggcctggg atgcccagag aatcttcaaa gaggctgaga agttctttgt 2220
gtctgtgggg ctgcccaaca tgacccaagg cttttgggag tactccatgc tgacagaccc 2280
tggcaatgtg caaaaggctg tgtgtcaccc cacagcctgg gaccttggca agggagactt 2340
cagaatcctg atgtgcacca aagtgacaat ggatgacttt ctgacagctc accatgagat 2400
gggccacatc cagtatgaca tggcctatgc tgcccagcct ttcctgctga gaaatggggc 2460
caatgagggc ttccatgagg cagtgggaga gatcatgagc ctgtctgctg ccacacctaa 2520
gcacctgaag tccattggcc tgctgagccc tgacttccaa gaggacaatg agacagagat 2580
caacttcctg ctcaagcagg ccctgaccat tgtgggcaca ctgcccttca cctacatgct 2640
ggaaaagtgg agatggatgg tctttaaggg agaaatcccc aaggaccagt ggatgaagaa 2700
atggtgggag atgaagaggg aaattgtggg agttgtggaa cctgtgccac atgatgagac 2760
atactgtgac cctgccagcc tgttccatgt gtccaatgac tactccttca ttaggtacta 2820
caccaggaca ctgtaccagt tccagtttca agaggctctg tgtcaggctg ctaaacatga 2880
gggcccactg cacaagtgtg acatcagcaa ctccacagag gctggacaga aactgttcaa 2940
catgctgaga ctgggcaagt ctgagccttg gactctggcc ctggaaaatg ttgtgggagc 3000
caagaatatg aatgtcagac ccctgctgaa ctactttgag cccctgttca cctggctgaa 3060
ggaccagaac aagaacagct ttgttggctg gtccacagac tggtccccat atgctgacca 3120
gagcatcaaa gtcagaatca gcctgaagag tgccctggga gataaggcct atgagtggaa 3180
tgataatgag atgtacctgt tcaggtcctc tgtggcttat gctatgagac agtactttct 3240
gaaagtgaag aaccagatga tcctgtttgg agaagaggat gtcagagtgg ccaacctgaa 3300
gcctagaatc agcttcaact tctttgtgac agcccctaag aatgtgtctg acatcatccc 3360
cagaacagag gtggaaaagg ccatcagaat gagcaggtcc aggatcaatg atgccttcag 3420
gctcaatgac aactccctgg aatttctggg cattcagccc acactgggcc ctccaaatca 3480
gcctcctgtg tcctaaagat ctacttctgg ctaataaaag atcagagctc tagtgatctg 3540
tgtgttggtt ttttgtgtct gcattctagc aagtcaatat gttcacccca aaaaagctgt 3600
ttgttaactt gtcaacctca ttctaaaatg tatatagaag cccaaaagac aataacaaaa 3660
atattcttgt agaacaaaat gggaaagaat gttccactaa atatcaagat ttagagcaaa 3720
gcatgagatg tgtggggata gacagtgagg ctgataaaat agagtagagc tcagaaacag 3780
acccattgat atatgtaagt gacctatgaa aaaaatatgg cattttacaa tgggaaaatg 3840
atggtctttt tcttttttag aaaaacaggg aaatatattt atatgtaaaa aataaaaggg 3900
aacccatatg tcataccata cacacaaaaa aattccagtg aattataagt ctaaatggag 3960
aaggcaaaac tttaaatctt ttagaaaata atatagaagc atgccatcaa gacttcagtg 4020
tagagaaaaa tttcttatga ctcaaagtcc taaccacaaa gaaaagattg ttaattagat 4080
tgcatgaata ttaagactta tttttaaaat taaaaaacca ttaagaaaag tcaggccata 4140
gaatgacaga aaatatttgc aacaccccag taaagagaat tgtaatatgc agattataaa 4200
aagaagtctt acaaatcagt aaaaaataaa actagacaaa aatttgaaca gatgaaagag 4260
aaactctaaa taatcattac acatgagaaa ctcaatctca gaaatcagag aactatcatt 4320
gcatatacac taaattagag aaatattaaa aggctaagta acatctgtgg cttaattaat 4380
ctagctctag tgatcagcag ttcaacctgt tgatagtatg tactaagctc tcatgtttaa 4440
tgtactaagc tctcatgttt aatgaactaa accctcatgg ctaatgtact aagctctcat 4500
ggctaatgta ctaagctctc atgtttcatg tactaagctc tcatgtttga acaataaaat 4560
taatataaat cagcaactta aatagcctct aaggttttaa gttttataag aaaaaaaaga 4620
atatataagg cttttaaagg ttttaaggtt tcctaggtta tcctcatatg agctcttaga 4680
aaaactcatc cagcatcaaa tgaaactgca atttattcat atcaggatta tcaataccat 4740
atttttgaaa aagtcttttc tgtaatgaag gagaaaactc acccaggcag ttccatagga 4800
tggcaagatc ctggtatctg tctgcaattc caactcttcc aacatcaata caacctatta 4860
atttcccctc atcaaaaata aggttatcaa gtgagaaatc accatgagtg accactgaat 4920
ctggtgagaa tggcaaaaga ttatgcattt ctttccagac ttgttcaaca ggccagccat 4980
ttctctcatc atcaaaatca ctggcatcaa ccaaaccatt attcattctt gattgggcct 5040
gagccagtct aaatactcta tcagagttaa aaggacaatt acaaacagga atggaatgca 5100
atcttctcag gaacactgcc agggcatcaa caatattttc acctgaatca ggatattctt 5160
ccaatacctg gaatgctgtt ttccctggga tggcagtggt gagtaaccat gcatcatcag 5220
gagttctgat aaaatgcttg atggttggaa gaggcataaa ttcagtcagc cagtttagtc 5280
tgaccatctc atctgtaaca tcattggcaa cagaaccttt gccatgtttc agaaacaact 5340
ctggggcatc tggcttccca tacaatctat agattgtggc acctgattgc ccaacattat 5400
ctctagccca tttataccca tataaatcag catccatgtt ggaatttaat cttggcctgg 5460
agcaagaggt ttctctttga atatggctca tacatgtgca cctcctatag tgagttgtat 5520
tatactatgc agatatacta tgccaatgtt taattgtcag 5560
<210> 22
<211> 6271
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic
<400> 22
cactatgtgt taattaaaat tatctctaag gcatgtgaac tggctgtctt ggttttcatc 60
tgtacttcat ctgctacctc tgtgacctga aacatattta taattccatt aagctgtgca 120
tatgatagat ttatcatatg tattttcctt aaaggatttt tgtaagaact aattgaattg 180
atacctgtaa agtctttatc acactaccca ataaataata aatctctttg ttcagctctc 240
tgtttctata aatatgtacc agttttattg tttttagtgg tagtgatttt attctctttc 300
tatatatata cacacacatg tgtgcattca taaatatata caatttttat gaataaaaaa 360
ttattagcaa tcaatattga aaaccactga tttttgttta tgtgagcaaa cagcagatta 420
aaaggaattt gaattctcat agctagcagg agtcaatggg aaaaacccat tggagccaag 480
tacactgact caatagggac tttccattgg gttttgccca gtacataagg tcaatagggg 540
gtgagtcaac aggaaagtcc cattggagcc aagtacattg agtcaatagg gactttccaa 600
tgggttttgc ccagtacata aggtcaatgg gaggtaagcc aatgggtttt tcccattact 660
gacatgtata ctgagtcatt agggactttc caatgggttt tgcccagtac ataaggtcaa 720
taggggtgaa tcaacaggaa agtcccattg gagccaagta cactgagtca atagggactt 780
tccattgggt tttgcccagt acaaaaggtc aatagggggt gagtcaatgg gtttttccca 840
ttattggcac atacataagg tcaatagggg tgactagtgg agaagagcat gcttgagggc 900
tgagtgcccc tcagtgggca gagagcacat ggcccacagt ccctgagaag ttggggggag 960
gggtgggcaa ttgaactggt gcctagagaa ggtggggctt gggtaaactg ggaaagtgat 1020
gtggtgtact ggctccacct ttttccccag ggtgggggag aaccatatat aagtgcagta 1080
gtctctgtga acattcaagc ttctgccttc tccctcctgt gagtttggta agtcactgac 1140
tgtctatgcc tgggaaaggg tgggcaggag atggggcagt gcaggaaaag tggcactatg 1200
aaccctgcag ccctagacaa ttgtactaac cttcttctct ttcctctcct gacaggttgg 1260
taaccaagcc accatgagca gcagctcttg gctgctgctg agtctggtgg ctgtgacagc 1320
tgcccagagc accattgagg aacaggccaa gaccttcctg gacaagttca accatgaggc 1380
tgaggacctg ttctaccaga gcagcctggc cagctggaac tacaacacca acatcactga 1440
agagaatgtg cagaacatga acaatgctgg ggacaagtgg agtgccttcc tgaaagagca 1500
gagcacactg gcccagatgt accctctgca agagatccag aacctgacag tgaagctcca 1560
gctccaggct ctccagcaga atggcagctc tgtgctgtct gaggacaaga gcaagagact 1620
gaacaccatc ctgaacacaa tgagcaccat ctacagcaca ggcaaagtgt gcaaccctga 1680
caaccctcaa gagtgcctgc tgctggaacc tggcctgaat gagatcatgg ccaacagcct 1740
ggactacaat gagagactgt gggcctggga gtcttggagg agtgaagtgg gaaagcagct 1800
gaggcccctg tatgaggaat atgtggtgct gaagaatgag atggccaggg ccaaccacta 1860
tgaggactat ggggattatt ggaggggaga ctatgaagtg aatggtgttg atggctatga 1920
ctacagcagg ggccagctga ttgaggatgt ggaacacacc tttgaggaaa tcaagcccct 1980
ctatgagcac ctccatgcct atgtcagagc caagctgatg aatgcttacc ccagctacat 2040
cagccccatt ggctgcctgc ctgctcatct gctgggagac atgtggggca gattctggac 2100
caacctgtac agcctgactg tgccctttgg ccagaaacct aacattgatg tgacagatgc 2160
catggtggat caggcctggg atgcccagag aatcttcaaa gaggctgaga agttctttgt 2220
gtctgtgggg ctgcccaaca tgacccaagg cttttgggag aactccatgc tgacagaccc 2280
tggcaatgtg caaaaggctg tgtgtcaccc cacagcctgg gaccttggca agggagactt 2340
cagaatcctg atgtgcacca aagtgacaat ggatgacttt ctgacagctc accatgagat 2400
gggccacatc cagtatgaca tggcctatgc tgcccagcct ttcctgctga gaaatggggc 2460
caatgagggc ttccatgagg cagtgggaga gatcatgagc ctgtctgctg ccacacctaa 2520
gcacctgaag tccattggcc tgctgagccc tgacttccaa gaggacaatg agacagagat 2580
caacttcctg ctcaagcagg ccctgaccat tgtgggcaca ctgcccttca cctacatgct 2640
ggaaaagtgg agatggatgg tctttaaggg agaaatcccc aaggaccagt ggatgaagaa 2700
atggtgggag atgaagaggg aaattgtggg agttgtggaa cctgtgccac atgatgagac 2760
atactgtgac cctgccagcc tgttccatgt gtccaatgac tactccttca ttaggtacta 2820
caccaggaca ctgtaccagt tccagtttca agaggctctg tgtcaggctg ctaaacatga 2880
gggcccactg cacaagtgtg acatcagcaa ctccacagag gctggacaga aactgttcaa 2940
catgctgaga ctgggcaagt ctgagccttg gactctggcc ctggaaaatg ttgtgggagc 3000
caagaatatg aatgtcagac ccctgctgaa ctactttgag cccctgttca cctggctgaa 3060
ggaccagaac aagaacagct ttgttggctg gtccacagac tggtccccat atgctgacca 3120
gagcatcaaa gtcagaatca gcctgaagag tgccctggga gataaggcct atgagtggaa 3180
tgataatgag atgtacctgt tcaggtcctc tgtggcttat gctatgagac agtactttct 3240
gaaagtgaag aaccagatga tcctgtttgg agaagaggat gtcagagtgg ccaacctgaa 3300
gcctagaatc agcttcaact tctttgtgac agcccctaag aatgtgtctg acatcatccc 3360
cagaacagag gtggaaaagg ccatcagaat gagcaggtcc aggatcaatg atgccttcag 3420
gctcaatgac aactccctgg aatttctggg cattcagccc acactgggcc ctccaaatca 3480
gcctcctgtg tctggtggag gaggtagtga gcccaagagc tgtgacaaga cccacacctg 3540
tcctccatgt cctgctccag agctgcttgg aggaccttct gtgtttctgt tccctccaaa 3600
gccaaaggac accctgatga tcagcagaac ccctgaagtg acctgtgtgg tggtggatgt 3660
gtcccatgag gacccagaag tgaagttcaa ttggtatgtg gatggtgttg aggtgcacaa 3720
tgccaagacc aagcctagag aggaacagta caacagcacc tacagggttg tgtcagtgct 3780
gactgtgctg caccaggact ggctgaatgg caaagagtac aagtgcaagg tgtccaacaa 3840
ggccctgcct gctcctattg aaaagaccat cagcaaggcc aagggacagc ctagggaacc 3900
ccaggtgtac acactgccac ctagcagaga tgagctgacc aagaatcagg tgtccctgac 3960
atgccttgtg aagggcttct acccttctga cattgcagtg gaatgggaga gcaatggcca 4020
gcctgagaac aactacaaga caacccctcc tgtgctggac tctgatggct cattcttcct 4080
gtactccaag ctgacagtgg acaagtccag atggcagcaa ggcaatgtgt tcagctgctc 4140
tgtgatgcat gaggccctgc acaaccacta cacacagaag tccctgtctc tgagccctgg 4200
caagtgaaga tctacttctg gctaataaaa gatcagagct ctagtgatct gtgtgttggt 4260
tttttgtgtc tgcattctag caagtcaata tgttcacccc aaaaaagctg tttgttaact 4320
tgtcaacctc attctaaaat gtatatagaa gcccaaaaga caataacaaa aatattcttg 4380
tagaacaaaa tgggaaagaa tgttccacta aatatcaaga tttagagcaa agcatgagat 4440
gtgtggggat agacagtgag gctgataaaa tagagtagag ctcagaaaca gacccattga 4500
tatatgtaag tgacctatga aaaaaatatg gcattttaca atgggaaaat gatggtcttt 4560
ttctttttta gaaaaacagg gaaatatatt tatatgtaaa aaataaaagg gaacccatat 4620
gtcataccat acacacaaaa aaattccagt gaattataag tctaaatgga gaaggcaaaa 4680
ctttaaatct tttagaaaat aatatagaag catgccatca agacttcagt gtagagaaaa 4740
atttcttatg actcaaagtc ctaaccacaa agaaaagatt gttaattaga ttgcatgaat 4800
attaagactt atttttaaaa ttaaaaaacc attaagaaaa gtcaggccat agaatgacag 4860
aaaatatttg caacacccca gtaaagagaa ttgtaatatg cagattataa aaagaagtct 4920
tacaaatcag taaaaaataa aactagacaa aaatttgaac agatgaaaga gaaactctaa 4980
ataatcatta cacatgagaa actcaatctc agaaatcaga gaactatcat tgcatataca 5040
ctaaattaga gaaatattaa aaggctaagt aacatctgtg gcttaattaa tctagctcta 5100
gtgatcagca gttcaacctg ttgatagtat gtactaagct ctcatgttta atgtactaag 5160
ctctcatgtt taatgaacta aaccctcatg gctaatgtac taagctctca tggctaatgt 5220
actaagctct catgtttcat gtactaagct ctcatgtttg aacaataaaa ttaatataaa 5280
tcagcaactt aaatagcctc taaggtttta agttttataa gaaaaaaaag aatatataag 5340
gcttttaaag gttttaaggt ttcctaggtt atcctcatat gagctcttag aaaaactcat 5400
ccagcatcaa atgaaactgc aatttattca tatcaggatt atcaatacca tatttttgaa 5460
aaagtctttt ctgtaatgaa ggagaaaact cacccaggca gttccatagg atggcaagat 5520
cctggtatct gtctgcaatt ccaactcttc caacatcaat acaacctatt aatttcccct 5580
catcaaaaat aaggttatca agtgagaaat caccatgagt gaccactgaa tctggtgaga 5640
atggcaaaag attatgcatt tctttccaga cttgttcaac aggccagcca tttctctcat 5700
catcaaaatc actggcatca accaaaccat tattcattct tgattgggcc tgagccagtc 5760
taaatactct atcagagtta aaaggacaat tacaaacagg aatggaatgc aatcttctca 5820
ggaacactgc cagggcatca acaatatttt cacctgaatc aggatattct tccaatacct 5880
ggaatgctgt tttccctggg atggcagtgg tgagtaacca tgcatcatca ggagttctga 5940
taaaatgctt gatggttgga agaggcataa attcagtcag ccagtttagt ctgaccatct 6000
catctgtaac atcattggca acagaacctt tgccatgttt cagaaacaac tctggggcat 6060
ctggcttccc atacaatcta tagattgtgg cacctgattg cccaacatta tctctagccc 6120
atttataccc atataaatca gcatccatgt tggaatttaa tcttggcctg gagcaagagg 6180
tttctctttg aatatggctc atacatgtgc acctcctata gtgagttgta ttatactatg 6240
cagatatact atgccaatgt ttaattgtca g 6271
<210> 23
<211> 6271
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic
<400> 23
cactatgtgt taattaaaat tatctctaag gcatgtgaac tggctgtctt ggttttcatc 60
tgtacttcat ctgctacctc tgtgacctga aacatattta taattccatt aagctgtgca 120
tatgatagat ttatcatatg tattttcctt aaaggatttt tgtaagaact aattgaattg 180
atacctgtaa agtctttatc acactaccca ataaataata aatctctttg ttcagctctc 240
tgtttctata aatatgtacc agttttattg tttttagtgg tagtgatttt attctctttc 300
tatatatata cacacacatg tgtgcattca taaatatata caatttttat gaataaaaaa 360
ttattagcaa tcaatattga aaaccactga tttttgttta tgtgagcaaa cagcagatta 420
aaaggaattt gaattctcat agctagcagg agtcaatggg aaaaacccat tggagccaag 480
tacactgact caatagggac tttccattgg gttttgccca gtacataagg tcaatagggg 540
gtgagtcaac aggaaagtcc cattggagcc aagtacattg agtcaatagg gactttccaa 600
tgggttttgc ccagtacata aggtcaatgg gaggtaagcc aatgggtttt tcccattact 660
gacatgtata ctgagtcatt agggactttc caatgggttt tgcccagtac ataaggtcaa 720
taggggtgaa tcaacaggaa agtcccattg gagccaagta cactgagtca atagggactt 780
tccattgggt tttgcccagt acaaaaggtc aatagggggt gagtcaatgg gtttttccca 840
ttattggcac atacataagg tcaatagggg tgactagtgg agaagagcat gcttgagggc 900
tgagtgcccc tcagtgggca gagagcacat ggcccacagt ccctgagaag ttggggggag 960
gggtgggcaa ttgaactggt gcctagagaa ggtggggctt gggtaaactg ggaaagtgat 1020
gtggtgtact ggctccacct ttttccccag ggtgggggag aaccatatat aagtgcagta 1080
gtctctgtga acattcaagc ttctgccttc tccctcctgt gagtttggta agtcactgac 1140
tgtctatgcc tgggaaaggg tgggcaggag atggggcagt gcaggaaaag tggcactatg 1200
aaccctgcag ccctagacaa ttgtactaac cttcttctct ttcctctcct gacaggttgg 1260
taaccaagcc accatgagca gcagctcttg gctgctgctg agtctggtgg ctgtgacagc 1320
tgcccagagc accattgagg aacaggccaa gaccttcctg gacaagttca accatgaggc 1380
tgaggacctg ttctaccaga gcagcctggc cagctggaac tacaacacca acatcactga 1440
agagaatgtg cagaacatga acaatgctgg ggacaagtgg agtgccttcc tgaaagagca 1500
gagcacactg gcccagatgt accctctgca agagatccag aacctgacag tgaagctcca 1560
gctccaggct ctccagcaga atggcagctc tgtgctgtct gaggacaaga gcaagagact 1620
gaacaccatc ctgaacacaa tgagcaccat ctacagcaca ggcaaagtgt gcaaccctga 1680
caaccctcaa gagtgcctgc tgctggaacc tggcctgaat gagatcatgg ccaacagcct 1740
ggactacaat gagagactgt gggcctggga gtcttggagg agtgaagtgg gaaagcagct 1800
gaggcccctg tatgaggaat atgtggtgct gaagaatgag atggccaggg ccaaccacta 1860
tgaggactat ggggattatt ggaggggaga ctatgaagtg aatggtgttg atggctatga 1920
ctacagcagg ggccagctga ttgaggatgt ggaacacacc tttgaggaaa tcaagcccct 1980
ctatgagcac ctccatgcct atgtcagagc caagctgatg aatgcttacc ccagctacat 2040
cagccccatt ggctgcctgc ctgctcatct gctgggagac atgtggggca gattctggac 2100
caacctgtac agcctgactg tgccctttgg ccagaaacct aacattgatg tgacagatgc 2160
catggtggat caggcctggg atgcccagag aatcttcaaa gaggctgaga agttctttgt 2220
gtctgtgggg ctgcccaaca tgacccaagg cttttgggag aactccatgc tgacagaccc 2280
tggcaatgtg caaaaggctg tgtgtcaccc cacagcctgg gaccttggca agggagactt 2340
cagaatcctg atgtgcacca aagtgacaat ggatgacttt ctgacagctc accatgagat 2400
gggccacatc cagtatgaca tggcctatgc tgcccagcct ttcctgctga gaaatggggc 2460
caatgagggc ttccatgagg cagtgggaga gatcatgagc ctgtctgctg ccacacctaa 2520
gcacctgaag tccattggcc tgctgagccc tgacttccaa gaggacaatg agacagagat 2580
caacttcctg ctcaagcagg ccctgaccat tgtgggcaca ctgcccttca cctacatgct 2640
ggaaaagtgg agatggatgg tctttaaggg agaaatcccc aaggaccagt ggatgaagaa 2700
atggtgggag atgaagaggg aaattgtggg agttgtggaa cctgtgccac atgatgagac 2760
atactgtgac cctgccagcc tgttccatgt gtccaatgac tactccttca ttaggtacta 2820
caccaggaca ctgtaccagt tccagtttca agaggctctg tgtcaggctg ctaaacatga 2880
gggcccactg cacaagtgtg acatcagcaa ctccacagag gctggacaga aactgttcaa 2940
catgctgaga ctgggcaagt ctgagccttg gactctggcc ctggaaaatg ttgtgggagc 3000
caagaatatg aatgtcagac ccctgctgaa ctactttgag cccctgttca cctggctgaa 3060
ggaccagaac aagaacagct ttgttggctg gtccacagac tggtccccat atgctgacca 3120
gagcatcaaa gtcagaatca gcctgaagag tgccctggga gataaggcct atgagtggaa 3180
tgataatgag atgtacctgt tcaggtcctc tgtggcttat gctatgagac agtactttct 3240
gaaagtgaag aaccagatga tcctgtttgg agaagaggat gtcagagtgg ccaacctgaa 3300
gcctagaatc agcttcaact tctttgtgac agcccctaag aatgtgtctg acatcatccc 3360
cagaacagag gtggaaaagg ccatcagaat gagcaggtcc aggatcaatg atgccttcag 3420
gctcaatgac aactccctgg aatttctggg cattcagccc acactgggcc ctccaaatca 3480
gcctcctgtg tctggtggag gaggtagtga gcccaagagc tgtgacaaga cccacacctg 3540
tcctccatgt cctgctccag aggctgctgg aggaccttct gtgtttctgt tccctccaaa 3600
gccaaaggac accctgatga tcagcagaac ccctgaagtg acctgtgtgg tggtggatgt 3660
gtcccatgag gacccagaag tgaagttcaa ttggtatgtg gatggtgttg aggtgcacaa 3720
tgccaagacc aagcctagag aggaacagta caacagcacc tacagggttg tgtcagtgct 3780
gactgtgctg caccaggact ggctgaatgg caaagagtac aagtgcaagg tgtccaacaa 3840
ggccctgcct gctcctattg aaaagaccat cagcaaggcc aagggacagc ctagggaacc 3900
ccaggtgtac acactgccac ctagcagaga tgagctgacc aagaatcagg tgtccctgac 3960
atgccttgtg aagggcttct acccttctga cattgcagtg gaatgggaga gcaatggcca 4020
gcctgagaac aactacaaga caacccctcc tgtgctggac tctgatggct cattcttcct 4080
gtactccaag ctgacagtgg acaagtccag atggcagcaa ggcaatgtgt tcagctgctc 4140
tgtgatgcat gaggccctgc acaaccacta cacacagaag tccctgtctc tgagccctgg 4200
caagtgaaga tctacttctg gctaataaaa gatcagagct ctagtgatct gtgtgttggt 4260
tttttgtgtc tgcattctag caagtcaata tgttcacccc aaaaaagctg tttgttaact 4320
tgtcaacctc attctaaaat gtatatagaa gcccaaaaga caataacaaa aatattcttg 4380
tagaacaaaa tgggaaagaa tgttccacta aatatcaaga tttagagcaa agcatgagat 4440
gtgtggggat agacagtgag gctgataaaa tagagtagag ctcagaaaca gacccattga 4500
tatatgtaag tgacctatga aaaaaatatg gcattttaca atgggaaaat gatggtcttt 4560
ttctttttta gaaaaacagg gaaatatatt tatatgtaaa aaataaaagg gaacccatat 4620
gtcataccat acacacaaaa aaattccagt gaattataag tctaaatgga gaaggcaaaa 4680
ctttaaatct tttagaaaat aatatagaag catgccatca agacttcagt gtagagaaaa 4740
atttcttatg actcaaagtc ctaaccacaa agaaaagatt gttaattaga ttgcatgaat 4800
attaagactt atttttaaaa ttaaaaaacc attaagaaaa gtcaggccat agaatgacag 4860
aaaatatttg caacacccca gtaaagagaa ttgtaatatg cagattataa aaagaagtct 4920
tacaaatcag taaaaaataa aactagacaa aaatttgaac agatgaaaga gaaactctaa 4980
ataatcatta cacatgagaa actcaatctc agaaatcaga gaactatcat tgcatataca 5040
ctaaattaga gaaatattaa aaggctaagt aacatctgtg gcttaattaa tctagctcta 5100
gtgatcagca gttcaacctg ttgatagtat gtactaagct ctcatgttta atgtactaag 5160
ctctcatgtt taatgaacta aaccctcatg gctaatgtac taagctctca tggctaatgt 5220
actaagctct catgtttcat gtactaagct ctcatgtttg aacaataaaa ttaatataaa 5280
tcagcaactt aaatagcctc taaggtttta agttttataa gaaaaaaaag aatatataag 5340
gcttttaaag gttttaaggt ttcctaggtt atcctcatat gagctcttag aaaaactcat 5400
ccagcatcaa atgaaactgc aatttattca tatcaggatt atcaatacca tatttttgaa 5460
aaagtctttt ctgtaatgaa ggagaaaact cacccaggca gttccatagg atggcaagat 5520
cctggtatct gtctgcaatt ccaactcttc caacatcaat acaacctatt aatttcccct 5580
catcaaaaat aaggttatca agtgagaaat caccatgagt gaccactgaa tctggtgaga 5640
atggcaaaag attatgcatt tctttccaga cttgttcaac aggccagcca tttctctcat 5700
catcaaaatc actggcatca accaaaccat tattcattct tgattgggcc tgagccagtc 5760
taaatactct atcagagtta aaaggacaat tacaaacagg aatggaatgc aatcttctca 5820
ggaacactgc cagggcatca acaatatttt cacctgaatc aggatattct tccaatacct 5880
ggaatgctgt tttccctggg atggcagtgg tgagtaacca tgcatcatca ggagttctga 5940
taaaatgctt gatggttgga agaggcataa attcagtcag ccagtttagt ctgaccatct 6000
catctgtaac atcattggca acagaacctt tgccatgttt cagaaacaac tctggggcat 6060
ctggcttccc atacaatcta tagattgtgg cacctgattg cccaacatta tctctagccc 6120
atttataccc atataaatca gcatccatgt tggaatttaa tcttggcctg gagcaagagg 6180
tttctctttg aatatggctc atacatgtgc acctcctata gtgagttgta ttatactatg 6240
cagatatact atgccaatgt ttaattgtca g 6271
<210> 24
<211> 6271
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic
<400> 24
cactatgtgt taattaaaat tatctctaag gcatgtgaac tggctgtctt ggttttcatc 60
tgtacttcat ctgctacctc tgtgacctga aacatattta taattccatt aagctgtgca 120
tatgatagat ttatcatatg tattttcctt aaaggatttt tgtaagaact aattgaattg 180
atacctgtaa agtctttatc acactaccca ataaataata aatctctttg ttcagctctc 240
tgtttctata aatatgtacc agttttattg tttttagtgg tagtgatttt attctctttc 300
tatatatata cacacacatg tgtgcattca taaatatata caatttttat gaataaaaaa 360
ttattagcaa tcaatattga aaaccactga tttttgttta tgtgagcaaa cagcagatta 420
aaaggaattt gaattctcat agctagcagg agtcaatggg aaaaacccat tggagccaag 480
tacactgact caatagggac tttccattgg gttttgccca gtacataagg tcaatagggg 540
gtgagtcaac aggaaagtcc cattggagcc aagtacattg agtcaatagg gactttccaa 600
tgggttttgc ccagtacata aggtcaatgg gaggtaagcc aatgggtttt tcccattact 660
gacatgtata ctgagtcatt agggactttc caatgggttt tgcccagtac ataaggtcaa 720
taggggtgaa tcaacaggaa agtcccattg gagccaagta cactgagtca atagggactt 780
tccattgggt tttgcccagt acaaaaggtc aatagggggt gagtcaatgg gtttttccca 840
ttattggcac atacataagg tcaatagggg tgactagtgg agaagagcat gcttgagggc 900
tgagtgcccc tcagtgggca gagagcacat ggcccacagt ccctgagaag ttggggggag 960
gggtgggcaa ttgaactggt gcctagagaa ggtggggctt gggtaaactg ggaaagtgat 1020
gtggtgtact ggctccacct ttttccccag ggtgggggag aaccatatat aagtgcagta 1080
gtctctgtga acattcaagc ttctgccttc tccctcctgt gagtttggta agtcactgac 1140
tgtctatgcc tgggaaaggg tgggcaggag atggggcagt gcaggaaaag tggcactatg 1200
aaccctgcag ccctagacaa ttgtactaac cttcttctct ttcctctcct gacaggttgg 1260
taaccaagcc accatgagca gcagctcttg gctgctgctg agtctggtgg ctgtgacagc 1320
tgcccagagc accattgagg aacaggccaa gtacttcctg gacaagttca accatgaggc 1380
tgaggacctg ttctaccaga gcagcctggc cagctggaac tacaacacca acatcactga 1440
agagaatgtg cagaacatga acaatgctgg ggacaagtgg agtgccttcc tgaaagagca 1500
gagcacaact gcccagatgt accctctgca agagatccag aacctgacag tgaagctcca 1560
gctccaggct ctccagcaga atggcagctc tgtgctgtct gaggacaaga gcaagagact 1620
gaacaccatc ctgaacacaa tgagcaccat ctacagcaca ggcaaagtgt gcaaccctga 1680
caaccctcaa gagtgcctgc tgctggaacc tggcctgaat gagatcatgg ccaacagcct 1740
ggactacaat gagagactgt gggcctggga gtcttggagg agtgaagtgg gaaagcagct 1800
gaggcccctg tatgaggaat atgtggtgct gaagaatgag atggccaggg ccaaccacta 1860
tgaggactat ggggattatt ggaggggaga ctatgaagtg aatggtgttg atggctatga 1920
ctacagcagg ggccagctga ttgaggatgt ggaacacacc tttgaggaaa tcaagcccct 1980
ctatgagcac ctccatgcct atgtcagagc caagctgatg aatgcttacc ccagctacat 2040
cagccccatt ggctgcctgc ctgctcatct gctgggagac atgtggggca gattctggac 2100
caacctgtac agcctgactg tgccctttgg ccagaaacct aacattgatg tgacagatgc 2160
catggtggat caggcctggg atgcccagag aatcttcaaa gaggctgaga agttctttgt 2220
gtctgtgggg ctgcccaaca tgacccaagg cttttgggag tactccatgc tgacagaccc 2280
tggcaatgtg caaaaggctg tgtgtcaccc cacagcctgg gaccttggca agggagactt 2340
cagaatcctg atgtgcacca aagtgacaat ggatgacttt ctgacagctc accatgagat 2400
gggccacatc cagtatgaca tggcctatgc tgcccagcct ttcctgctga gaaatggggc 2460
caatgagggc ttccatgagg cagtgggaga gatcatgagc ctgtctgctg ccacacctaa 2520
gcacctgaag tccattggcc tgctgagccc tgacttccaa gaggacaatg agacagagat 2580
caacttcctg ctcaagcagg ccctgaccat tgtgggcaca ctgcccttca cctacatgct 2640
ggaaaagtgg agatggatgg tctttaaggg agaaatcccc aaggaccagt ggatgaagaa 2700
atggtgggag atgaagaggg aaattgtggg agttgtggaa cctgtgccac atgatgagac 2760
atactgtgac cctgccagcc tgttccatgt gtccaatgac tactccttca ttaggtacta 2820
caccaggaca ctgtaccagt tccagtttca agaggctctg tgtcaggctg ctaaacatga 2880
gggcccactg cacaagtgtg acatcagcaa ctccacagag gctggacaga aactgttcaa 2940
catgctgaga ctgggcaagt ctgagccttg gactctggcc ctggaaaatg ttgtgggagc 3000
caagaatatg aatgtcagac ccctgctgaa ctactttgag cccctgttca cctggctgaa 3060
ggaccagaac aagaacagct ttgttggctg gtccacagac tggtccccat atgctgacca 3120
gagcatcaaa gtcagaatca gcctgaagag tgccctggga gataaggcct atgagtggaa 3180
tgataatgag atgtacctgt tcaggtcctc tgtggcttat gctatgagac agtactttct 3240
gaaagtgaag aaccagatga tcctgtttgg agaagaggat gtcagagtgg ccaacctgaa 3300
gcctagaatc agcttcaact tctttgtgac agcccctaag aatgtgtctg acatcatccc 3360
cagaacagag gtggaaaagg ccatcagaat gagcaggtcc aggatcaatg atgccttcag 3420
gctcaatgac aactccctgg aatttctggg cattcagccc acactgggcc ctccaaatca 3480
gcctcctgtg tctggtggag gaggtagtga gcccaagagc tgtgacaaga cccacacctg 3540
tcctccatgt cctgctccag aggctgctgg aggaccttct gtgtttctgt tccctccaaa 3600
gccaaaggac accctgatga tcagcagaac ccctgaagtg acctgtgtgg tggtggatgt 3660
gtcccatgag gacccagaag tgaagttcaa ttggtatgtg gatggtgttg aggtgcacaa 3720
tgccaagacc aagcctagag aggaacagta caacagcacc tacagggttg tgtcagtgct 3780
gactgtgctg caccaggact ggctgaatgg caaagagtac aagtgcaagg tgtccaacaa 3840
ggccctgcct gctcctattg aaaagaccat cagcaaggcc aagggacagc ctagggaacc 3900
ccaggtgtac acactgccac ctagcagaga tgagctgacc aagaatcagg tgtccctgac 3960
atgccttgtg aagggcttct acccttctga cattgcagtg gaatgggaga gcaatggcca 4020
gcctgagaac aactacaaga caacccctcc tgtgctggac tctgatggct cattcttcct 4080
gtactccaag ctgacagtgg acaagtccag atggcagcaa ggcaatgtgt tcagctgctc 4140
tgtgatgcat gaggccctgc acaaccacta cacacagaag tccctgtctc tgagccctgg 4200
caagtgaaga tctacttctg gctaataaaa gatcagagct ctagtgatct gtgtgttggt 4260
tttttgtgtc tgcattctag caagtcaata tgttcacccc aaaaaagctg tttgttaact 4320
tgtcaacctc attctaaaat gtatatagaa gcccaaaaga caataacaaa aatattcttg 4380
tagaacaaaa tgggaaagaa tgttccacta aatatcaaga tttagagcaa agcatgagat 4440
gtgtggggat agacagtgag gctgataaaa tagagtagag ctcagaaaca gacccattga 4500
tatatgtaag tgacctatga aaaaaatatg gcattttaca atgggaaaat gatggtcttt 4560
ttctttttta gaaaaacagg gaaatatatt tatatgtaaa aaataaaagg gaacccatat 4620
gtcataccat acacacaaaa aaattccagt gaattataag tctaaatgga gaaggcaaaa 4680
ctttaaatct tttagaaaat aatatagaag catgccatca agacttcagt gtagagaaaa 4740
atttcttatg actcaaagtc ctaaccacaa agaaaagatt gttaattaga ttgcatgaat 4800
attaagactt atttttaaaa ttaaaaaacc attaagaaaa gtcaggccat agaatgacag 4860
aaaatatttg caacacccca gtaaagagaa ttgtaatatg cagattataa aaagaagtct 4920
tacaaatcag taaaaaataa aactagacaa aaatttgaac agatgaaaga gaaactctaa 4980
ataatcatta cacatgagaa actcaatctc agaaatcaga gaactatcat tgcatataca 5040
ctaaattaga gaaatattaa aaggctaagt aacatctgtg gcttaattaa tctagctcta 5100
gtgatcagca gttcaacctg ttgatagtat gtactaagct ctcatgttta atgtactaag 5160
ctctcatgtt taatgaacta aaccctcatg gctaatgtac taagctctca tggctaatgt 5220
actaagctct catgtttcat gtactaagct ctcatgtttg aacaataaaa ttaatataaa 5280
tcagcaactt aaatagcctc taaggtttta agttttataa gaaaaaaaag aatatataag 5340
gcttttaaag gttttaaggt ttcctaggtt atcctcatat gagctcttag aaaaactcat 5400
ccagcatcaa atgaaactgc aatttattca tatcaggatt atcaatacca tatttttgaa 5460
aaagtctttt ctgtaatgaa ggagaaaact cacccaggca gttccatagg atggcaagat 5520
cctggtatct gtctgcaatt ccaactcttc caacatcaat acaacctatt aatttcccct 5580
catcaaaaat aaggttatca agtgagaaat caccatgagt gaccactgaa tctggtgaga 5640
atggcaaaag attatgcatt tctttccaga cttgttcaac aggccagcca tttctctcat 5700
catcaaaatc actggcatca accaaaccat tattcattct tgattgggcc tgagccagtc 5760
taaatactct atcagagtta aaaggacaat tacaaacagg aatggaatgc aatcttctca 5820
ggaacactgc cagggcatca acaatatttt cacctgaatc aggatattct tccaatacct 5880
ggaatgctgt tttccctggg atggcagtgg tgagtaacca tgcatcatca ggagttctga 5940
taaaatgctt gatggttgga agaggcataa attcagtcag ccagtttagt ctgaccatct 6000
catctgtaac atcattggca acagaacctt tgccatgttt cagaaacaac tctggggcat 6060
ctggcttccc atacaatcta tagattgtgg cacctgattg cccaacatta tctctagccc 6120
atttataccc atataaatca gcatccatgt tggaatttaa tcttggcctg gagcaagagg 6180
tttctctttg aatatggctc atacatgtgc acctcctata gtgagttgta ttatactatg 6240
cagatatact atgccaatgt ttaattgtca g 6271
<210> 25
<211> 9747
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic
<400> 25
cactatgtgt taattaaaat tatctctaag gcatgtgaac tggctgtctt ggttttcatc 60
tgtacttcat ctgctacctc tgtgacctga aacatattta taattccatt aagctgtgca 120
tatgatagat ttatcatatg tattttcctt aaaggatttt tgtaagaact aattgaattg 180
atacctgtaa agtctttatc acactaccca ataaataata aatctctttg ttcagctctc 240
tgtttctata aatatgtacc agttttattg tttttagtgg tagtgatttt attctctttc 300
tatatatata cacacacatg tgtgcattca taaatatata caatttttat gaataaaaaa 360
ttattagcaa tcaatattga aaaccactga tttttgttta tgtgagcaaa cagcagatta 420
aaaggaattt gaattctcat agctagcagg agtcaatggg aaaaacccat tggagccaag 480
tacactgact caatagggac tttccattgg gttttgccca gtacataagg tcaatagggg 540
gtgagtcaac aggaaagtcc cattggagcc aagtacattg agtcaatagg gactttccaa 600
tgggttttgc ccagtacata aggtcaatgg gaggtaagcc aatgggtttt tcccattact 660
gacatgtata ctgagtcatt agggactttc caatgggttt tgcccagtac ataaggtcaa 720
taggggtgaa tcaacaggaa agtcccattg gagccaagta cactgagtca atagggactt 780
tccattgggt tttgcccagt acaaaaggtc aatagggggt gagtcaatgg gtttttccca 840
ttattggcac atacataagg tcaatagggg tgactagtgg agaagagcat gcttgagggc 900
tgagtgcccc tcagtgggca gagagcacat ggcccacagt ccctgagaag ttggggggag 960
gggtgggcaa ttgaactggt gcctagagaa ggtggggctt gggtaaactg ggaaagtgat 1020
gtggtgtact ggctccacct ttttccccag ggtgggggag aaccatatat aagtgcagta 1080
gtctctgtga acattcaagc ttctgccttc tccctcctgt gagtttggta agtcactgac 1140
tgtctatgcc tgggaaaggg tgggcaggag atggggcagt gcaggaaaag tggcactatg 1200
aaccctgcag ccctagacaa ttgtactaac cttcttctct ttcctctcct gacaggttgg 1260
taaccaagcc accatgagca gcagctcttg gctgctgctg agtctggtgg ctgtgacagc 1320
tgcccagagc accattgagg aacaggccaa gaccttcctg gacaagttca accatgaggc 1380
tgaggacctg ttctaccaga gcagcctggc cagctggaac tacaacacca acatcactga 1440
agagaatgtg cagaacatga acaatgctgg ggacaagtgg agtgccttcc tgaaagagca 1500
gagcacactg gcccagatgt accctctgca agagatccag aacctgacag tgaagctcca 1560
gctccaggct ctccagcaga atggcagctc tgtgctgtct gaggacaaga gcaagagact 1620
gaacaccatc ctgaacacaa tgagcaccat ctacagcaca ggcaaagtgt gcaaccctga 1680
caaccctcaa gagtgcctgc tgctggaacc tggcctgaat gagatcatgg ccaacagcct 1740
ggactacaat gagagactgt gggcctggga gtcttggagg agtgaagtgg gaaagcagct 1800
gaggcccctg tatgaggaat atgtggtgct gaagaatgag atggccaggg ccaaccacta 1860
tgaggactat ggggattatt ggaggggaga ctatgaagtg aatggtgttg atggctatga 1920
ctacagcagg ggccagctga ttgaggatgt ggaacacacc tttgaggaaa tcaagcccct 1980
ctatgagcac ctccatgcct atgtcagagc caagctgatg aatgcttacc ccagctacat 2040
cagccccatt ggctgcctgc ctgctcatct gctgggagac atgtggggca gattctggac 2100
caacctgtac agcctgactg tgccctttgg ccagaaacct aacattgatg tgacagatgc 2160
catggtggat caggcctggg atgcccagag aatcttcaaa gaggctgaga agttctttgt 2220
gtctgtgggg ctgcccaaca tgacccaagg cttttgggag aactccatgc tgacagaccc 2280
tggcaatgtg caaaaggctg tgtgtcaccc cacagcctgg gaccttggca agggagactt 2340
cagaatcctg atgtgcacca aagtgacaat ggatgacttt ctgacagctc accatgagat 2400
gggccacatc cagtatgaca tggcctatgc tgcccagcct ttcctgctga gaaatggggc 2460
caatgagggc ttccatgagg cagtgggaga gatcatgagc ctgtctgctg ccacacctaa 2520
gcacctgaag tccattggcc tgctgagccc tgacttccaa gaggacaatg agacagagat 2580
caacttcctg ctcaagcagg ccctgaccat tgtgggcaca ctgcccttca cctacatgct 2640
ggaaaagtgg agatggatgg tctttaaggg agaaatcccc aaggaccagt ggatgaagaa 2700
atggtgggag atgaagaggg aaattgtggg agttgtggaa cctgtgccac atgatgagac 2760
atactgtgac cctgccagcc tgttccatgt gtccaatgac tactccttca ttaggtacta 2820
caccaggaca ctgtaccagt tccagtttca agaggctctg tgtcaggctg ctaaacatga 2880
gggcccactg cacaagtgtg acatcagcaa ctccacagag gctggacaga aactgttcaa 2940
catgctgaga ctgggcaagt ctgagccttg gactctggcc ctggaaaatg ttgtgggagc 3000
caagaatatg aatgtcagac ccctgctgaa ctactttgag cccctgttca cctggctgaa 3060
ggaccagaac aagaacagct ttgttggctg gtccacagac tggtccccat atgctgacca 3120
gagcatcaaa gtcagaatca gcctgaagag tgccctggga gataaggcct atgagtggaa 3180
tgataatgag atgtacctgt tcaggtcctc tgtggcttat gctatgagac agtactttct 3240
gaaagtgaag aaccagatga tcctgtttgg agaagaggat gtcagagtgg ccaacctgaa 3300
gcctagaatc agcttcaact tctttgtgac agcccctaag aatgtgtctg acatcatccc 3360
cagaacagag gtggaaaagg ccatcagaat gagcaggtcc aggatcaatg atgccttcag 3420
gctcaatgac aactccctgg aatttctggg cattcagccc acactgggcc ctccaaatca 3480
gcctcctgtg tcctaaagat ctacttctgg ctaataaaag atcagagctc tagtgatctg 3540
tgtgttggtt ttttgtgtct gcattctagc agagccccac tgtgttcatc ttacagatgg 3600
aaatactgac attcagagga gttagttaac ttgcctaggt gattcagcta ataagtgcaa 3660
gaaagatttc aatccaaggt gatttgattc tgaagcctgt gctaatcaca ttacaccaag 3720
ctacaacttc atttataaat aataagtcag ctttcaaggg cctttcaggt gtcctgcact 3780
tctacaagct gtgccattta gtgaacacaa aatgagcctt ctgatgaagt agtcttttca 3840
ttatttcaga tattagaaca ctaaaattct tagctgccag ctgattgaag gctgggacaa 3900
aattcaaaca tgcatctaca acaatatata tctcaatgtt agtctccaaa ttctattgac 3960
ttcaactcaa gagaatataa agagctagtc tttatacact ctttaaggta tgatatcatc 4020
tggaaagtaa caaaattgat gcaaatttga atgaacttta tcatggtgta tttacacaat 4080
gtgtttcttc tccctgcaat gtatttcttt ctctaattcc ttccatttga tctttcatac 4140
acaatctggt tctgatgtat gttttttgga tgcacttttc aactccaaaa gacagagcta 4200
gttactttct tcctggtgct ccaagcactg tatttgtatc tgtattcaag ccctttgcaa 4260
tattgtactg gatcattatt tcacctctag gatggcttcc ccaggcaact tgtgttcacc 4320
cagagactac attttgtatc ttgttgacct ttgaacttcc accagtgtct aaaaataata 4380
tgtatgcaaa attacttgct atgagaatgt ataattaaac aatataaaaa ggagaagcaa 4440
ggagagaaac acaggtgtgt atttgtgttt gtgtgcttaa aaggcagtgt ggaaaaggaa 4500
gaaatgccat ttatagtgag gagacaaagt tatattacct cttatctggc ttttaaggag 4560
attttgctga gctaaaaatc ctatattcat agaaaagcct tacctgagtt gccaatacct 4620
caattcagtc tagcaggagt caatgggaaa aacccattgg agccaagtac actgactcaa 4680
tagggacttt ccattgggtt ttgcccagta cataaggtca atagggggtg agtcaacagg 4740
aaagtcccat tggagccaag tacattgagt caatagggac tttccaatgg gttttgccca 4800
gtacataagg tcaatgggag gtaagccaat gggtttttcc cattactgac atgtatactg 4860
agtcattagg gactttccaa tgggttttgc ccagtacata aggtcaatag gggtgaatca 4920
acaggaaagt cccattggag ccaagtacac tgagtcaata gggactttcc attgggtttt 4980
gcccagtaca aaaggtcaat agggggtgag tcaatgggtt tttcccatta ttggcacata 5040
cataaggtca ataggggtga ctagtggaga agagcatgct tgagggctga gtgcccctca 5100
gtgggcagag agcacatggc ccacagtccc tgagaagttg gggggagggg tgggcaattg 5160
aactggtgcc tagagaaggt ggggcttggg taaactggga aagtgatgtg gtgtactggc 5220
tccacctttt tccccagggt gggggagaac catatataag tgcagtagtc tctgtgaaca 5280
ttcaagcttc tgccttctcc ctcctgtgag tttggtaagt cactgactgt ctatgcctgg 5340
gaaagggtgg gcaggagatg gggcagtgca ggaaaagtgg cactatgaac cctgcagccc 5400
tagacaattg tactaacctt cttctctttc ctctcctgac aggttggtaa ccaagccacc 5460
atgagcagca gctcttggct gctgctgagt ctggtggctg tgacagctgc ccagagcacc 5520
attgaggaac aggccaagac cttcctggac aagttcaacc atgaggctga ggacctgttc 5580
taccagagca gcctggccag ctggaactac aacaccaaca tcactgaaga gaatgtgcag 5640
aacatgaaca atgctgggga caagtggagt gccttcctga aagagcagag cacactggcc 5700
cagatgtacc ctctgcaaga gatccagaac ctgacagtga agctccagct ccaggctctc 5760
cagcagaatg gcagctctgt gctgtctgag gacaagagca agagactgaa caccatcctg 5820
aacacaatga gcaccatcta cagcacaggc aaagtgtgca accctgacaa ccctcaagag 5880
tgcctgctgc tggaacctgg cctgaatgag atcatggcca acagcctgga ctacaatgag 5940
agactgtggg cctgggagtc ttggaggagt gaagtgggaa agcagctgag gcccctgtat 6000
gaggaatatg tggtgctgaa gaatgagatg gccagggcca accactatga ggactatggg 6060
gattattgga ggggagacta tgaagtgaat ggtgttgatg gctatgacta cagcaggggc 6120
cagctgattg aggatgtgga acacaccttt gaggaaatca agcccctcta tgagcacctc 6180
catgcctatg tcagagccaa gctgatgaat gcttacccca gctacatcag ccccattggc 6240
tgcctgcctg ctcatctgct gggagacatg tggggcagat tctggaccaa cctgtacagc 6300
ctgactgtgc cctttggcca gaaacctaac attgatgtga cagatgccat ggtggatcag 6360
gcctgggatg cccagagaat cttcaaagag gctgagaagt tctttgtgtc tgtggggctg 6420
cccaacatga cccaaggctt ttgggagaac tccatgctga cagaccctgg caatgtgcaa 6480
aaggctgtgt gtcaccccac agcctgggac cttggcaagg gagacttcag aatcctgatg 6540
tgcaccaaag tgacaatgga tgactttctg acagctcacc atgagatggg ccacatccag 6600
tatgacatgg cctatgctgc ccagcctttc ctgctgagaa atggggccaa tgagggcttc 6660
catgaggcag tgggagagat catgagcctg tctgctgcca cacctaagca cctgaagtcc 6720
attggcctgc tgagccctga cttccaagag gacaatgaga cagagatcaa cttcctgctc 6780
aagcaggccc tgaccattgt gggcacactg cccttcacct acatgctgga aaagtggaga 6840
tggatggtct ttaagggaga aatccccaag gaccagtgga tgaagaaatg gtgggagatg 6900
aagagggaaa ttgtgggagt tgtggaacct gtgccacatg atgagacata ctgtgaccct 6960
gccagcctgt tccatgtgtc caatgactac tccttcatta ggtactacac caggacactg 7020
taccagttcc agtttcaaga ggctctgtgt caggctgcta aacatgaggg cccactgcac 7080
aagtgtgaca tcagcaactc cacagaggct ggacagaaac tgttcaacat gctgagactg 7140
ggcaagtctg agccttggac tctggccctg gaaaatgttg tgggagccaa gaatatgaat 7200
gtcagacccc tgctgaacta ctttgagccc ctgttcacct ggctgaagga ccagaacaag 7260
aacagctttg ttggctggtc cacagactgg tccccatatg ctgaccagag catcaaagtc 7320
agaatcagcc tgaagagtgc cctgggagat aaggcctatg agtggaatga taatgagatg 7380
tacctgttca ggtcctctgt ggcttatgct atgagacagt actttctgaa agtgaagaac 7440
cagatgatcc tgtttggaga agaggatgtc agagtggcca acctgaagcc tagaatcagc 7500
ttcaacttct ttgtgacagc ccctaagaat gtgtctgaca tcatccccag aacagaggtg 7560
gaaaaggcca tcagaatgag caggtccagg atcaatgatg ccttcaggct caatgacaac 7620
tccctggaat ttctgggcat tcagcccaca ctgggccctc caaatcagcc tcctgtgtcc 7680
taaagatcta cttctggcta ataaaagatc agagctctag tgatctgtgt gttggttttt 7740
tgtgtctgca ttctagcaag tcaatatgtt caccccaaaa aagctgtttg ttaacttgtc 7800
aacctcattc taaaatgtat atagaagccc aaaagacaat aacaaaaata ttcttgtaga 7860
acaaaatggg aaagaatgtt ccactaaata tcaagattta gagcaaagca tgagatgtgt 7920
ggggatagac agtgaggctg ataaaataga gtagagctca gaaacagacc cattgatata 7980
tgtaagtgac ctatgaaaaa aatatggcat tttacaatgg gaaaatgatg gtctttttct 8040
tttttagaaa aacagggaaa tatatttata tgtaaaaaat aaaagggaac ccatatgtca 8100
taccatacac acaaaaaaat tccagtgaat tataagtcta aatggagaag gcaaaacttt 8160
aaatctttta gaaaataata tagaagcatg ccatcaagac ttcagtgtag agaaaaattt 8220
cttatgactc aaagtcctaa ccacaaagaa aagattgtta attagattgc atgaatatta 8280
agacttattt ttaaaattaa aaaaccatta agaaaagtca ggccatagaa tgacagaaaa 8340
tatttgcaac accccagtaa agagaattgt aatatgcaga ttataaaaag aagtcttaca 8400
aatcagtaaa aaataaaact agacaaaaat ttgaacagat gaaagagaaa ctctaaataa 8460
tcattacaca tgagaaactc aatctcagaa atcagagaac tatcattgca tatacactaa 8520
attagagaaa tattaaaagg ctaagtaaca tctgtggctt aattaatcta gctctagtga 8580
tcagcagttc aacctgttga tagtatgtac taagctctca tgtttaatgt actaagctct 8640
catgtttaat gaactaaacc ctcatggcta atgtactaag ctctcatggc taatgtacta 8700
agctctcatg tttcatgtac taagctctca tgtttgaaca ataaaattaa tataaatcag 8760
caacttaaat agcctctaag gttttaagtt ttataagaaa aaaaagaata tataaggctt 8820
ttaaaggttt taaggtttcc taggttatcc tcatatgagc tcttagaaaa actcatccag 8880
catcaaatga aactgcaatt tattcatatc aggattatca ataccatatt tttgaaaaag 8940
tcttttctgt aatgaaggag aaaactcacc caggcagttc cataggatgg caagatcctg 9000
gtatctgtct gcaattccaa ctcttccaac atcaatacaa cctattaatt tcccctcatc 9060
aaaaataagg ttatcaagtg agaaatcacc atgagtgacc actgaatctg gtgagaatgg 9120
caaaagatta tgcatttctt tccagacttg ttcaacaggc cagccatttc tctcatcatc 9180
aaaatcactg gcatcaacca aaccattatt cattcttgat tgggcctgag ccagtctaaa 9240
tactctatca gagttaaaag gacaattaca aacaggaatg gaatgcaatc ttctcaggaa 9300
cactgccagg gcatcaacaa tattttcacc tgaatcagga tattcttcca atacctggaa 9360
tgctgttttc cctgggatgg cagtggtgag taaccatgca tcatcaggag ttctgataaa 9420
atgcttgatg gttggaagag gcataaattc agtcagccag tttagtctga ccatctcatc 9480
tgtaacatca ttggcaacag aacctttgcc atgtttcaga aacaactctg gggcatctgg 9540
cttcccatac aatctataga ttgtggcacc tgattgccca acattatctc tagcccattt 9600
atacccatat aaatcagcat ccatgttgga atttaatctt ggcctggagc aagaggtttc 9660
tctttgaata tggctcatac atgtgcacct cctatagtga gttgtattat actatgcaga 9720
tatactatgc caatgtttaa ttgtcag 9747
<210> 26
<211> 9711
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic
<400> 26
cactatgtgt taattaaaat tatctctaag gcatgtgaac tggctgtctt ggttttcatc 60
tgtacttcat ctgctacctc tgtgacctga aacatattta taattccatt aagctgtgca 120
tatgatagat ttatcatatg tattttcctt aaaggatttt tgtaagaact aattgaattg 180
atacctgtaa agtctttatc acactaccca ataaataata aatctctttg ttcagctctc 240
tgtttctata aatatgtacc agttttattg tttttagtgg tagtgatttt attctctttc 300
tatatatata cacacacatg tgtgcattca taaatatata caatttttat gaataaaaaa 360
ttattagcaa tcaatattga aaaccactga tttttgttta tgtgagcaaa cagcagatta 420
aaaggaattt gaattctcat agctagcagg agtcaatggg aaaaacccat tggagccaag 480
tacactgact caatagggac tttccattgg gttttgccca gtacataagg tcaatagggg 540
gtgagtcaac aggaaagtcc cattggagcc aagtacattg agtcaatagg gactttccaa 600
tgggttttgc ccagtacata aggtcaatgg gaggtaagcc aatgggtttt tcccattact 660
gacatgtata ctgagtcatt agggactttc caatgggttt tgcccagtac ataaggtcaa 720
taggggtgaa tcaacaggaa agtcccattg gagccaagta cactgagtca atagggactt 780
tccattgggt tttgcccagt acaaaaggtc aatagggggt gagtcaatgg gtttttccca 840
ttattggcac atacataagg tcaatagggg tgactagtgg agaagagcat gcttgagggc 900
tgagtgcccc tcagtgggca gagagcacat ggcccacagt ccctgagaag ttggggggag 960
gggtgggcaa ttgaactggt gcctagagaa ggtggggctt gggtaaactg ggaaagtgat 1020
gtggtgtact ggctccacct ttttccccag ggtgggggag aaccatatat aagtgcagta 1080
gtctctgtga acattcaagc ttctgccttc tccctcctgt gagtttggta agtcactgac 1140
tgtctatgcc tgggaaaggg tgggcaggag atggggcagt gcaggaaaag tggcactatg 1200
aaccctgcag ccctagacaa ttgtactaac cttcttctct ttcctctcct gacaggttgg 1260
taaccaagcc accatgagca gcagctcttg gctgctgctg agtctggtgg ctgtgacagc 1320
tgcccagagc accattgagg aacaggccaa gaccttcctg gacaagttca accatgaggc 1380
tgaggacctg ttctaccaga gcagcctggc cagctggaac tacaacacca acatcactga 1440
agagaatgtg cagaacatga acaatgctgg ggacaagtgg agtgccttcc tgaaagagca 1500
gagcacactg gcccagatgt accctctgca agagatccag aacctgacag tgaagctcca 1560
gctccaggct ctccagcaga atggcagctc tgtgctgtct gaggacaaga gcaagagact 1620
gaacaccatc ctgaacacaa tgagcaccat ctacagcaca ggcaaagtgt gcaaccctga 1680
caaccctcaa gagtgcctgc tgctggaacc tggcctgaat gagatcatgg ccaacagcct 1740
ggactacaat gagagactgt gggcctggga gtcttggagg agtgaagtgg gaaagcagct 1800
gaggcccctg tatgaggaat atgtggtgct gaagaatgag atggccaggg ccaaccacta 1860
tgaggactat ggggattatt ggaggggaga ctatgaagtg aatggtgttg atggctatga 1920
ctacagcagg ggccagctga ttgaggatgt ggaacacacc tttgaggaaa tcaagcccct 1980
ctatgagcac ctccatgcct atgtcagagc caagctgatg aatgcttacc ccagctacat 2040
cagccccatt ggctgcctgc ctgctcatct gctgggagac atgtggggca gattctggac 2100
caacctgtac agcctgactg tgccctttgg ccagaaacct aacattgatg tgacagatgc 2160
catggtggat caggcctggg atgcccagag aatcttcaaa gaggctgaga agttctttgt 2220
gtctgtgggg ctgcccaaca tgacccaagg cttttgggag aactccatgc tgacagaccc 2280
tggcaatgtg caaaaggctg tgtgtcaccc cacagcctgg gaccttggca agggagactt 2340
cagaatcctg atgtgcacca aagtgacaat ggatgacttt ctgacagctc accatgagat 2400
gggccacatc cagtatgaca tggcctatgc tgcccagcct ttcctgctga gaaatggggc 2460
caatgagggc ttccatgagg cagtgggaga gatcatgagc ctgtctgctg ccacacctaa 2520
gcacctgaag tccattggcc tgctgagccc tgacttccaa gaggacaatg agacagagat 2580
caacttcctg ctcaagcagg ccctgaccat tgtgggcaca ctgcccttca cctacatgct 2640
ggaaaagtgg agatggatgg tctttaaggg agaaatcccc aaggaccagt ggatgaagaa 2700
atggtgggag atgaagaggg aaattgtggg agttgtggaa cctgtgccac atgatgagac 2760
atactgtgac cctgccagcc tgttccatgt gtccaatgac tactccttca ttaggtacta 2820
caccaggaca ctgtaccagt tccagtttca agaggctctg tgtcaggctg ctaaacatga 2880
gggcccactg cacaagtgtg acatcagcaa ctccacagag gctggacaga aactgttcaa 2940
catgctgaga ctgggcaagt ctgagccttg gactctggcc ctggaaaatg ttgtgggagc 3000
caagaatatg aatgtcagac ccctgctgaa ctactttgag cccctgttca cctggctgaa 3060
ggaccagaac aagaacagct ttgttggctg gtccacagac tggtccccat atgctgacca 3120
gagcatcaaa gtcagaatca gcctgaagag tgccctggga gataaggcct atgagtggaa 3180
tgataatgag atgtacctgt tcaggtcctc tgtggcttat gctatgagac agtactttct 3240
gaaagtgaag aaccagatga tcctgtttgg agaagaggat gtcagagtgg ccaacctgaa 3300
gcctagaatc agcttcaact tctttgtgac agcccctaag aatgtgtctg acatcatccc 3360
cagaacagag gtggaaaagg ccatcagaat gagcaggtcc aggatcaatg atgccttcag 3420
gctcaatgac aactccctgg aatttctggg cattcagccc acactgggcc ctccaaatca 3480
gcctcctgtg tcctaaagat ctacttctgg ctaataaaag atcagagctc tagtgatctg 3540
tgtgttggtt ttttgtgtct gcattctagc agagccccac tgtgttcatc ttacagatgg 3600
aaatactgac attcagagga gttagttaac ttgcctaggt gattcagcta ataagtgcaa 3660
gaaagatttc aatccaaggt gatttgattc tgaagcctgt gctaatcaca ttacaccaag 3720
ctacaacttc atttataaat aataagtcag ctttcaaggg cctttcaggt gtcctgcact 3780
tctacaagct gtgccattta gtgaacacaa aatgagcctt ctgatgaagt agtcttttca 3840
ttatttcaga tattagaaca ctaaaattct tagctgccag ctgattgaag gctgggacaa 3900
aattcaaaca tgcatctaca acaatatata tctcaatgtt agtctccaaa ttctattgac 3960
ttcaactcaa gagaatataa agagctagtc tttatacact ctttaaggta tgatatcatc 4020
tggaaagtaa caaaattgat gcaaatttga atgaacttta tcatggtgta tttacacaat 4080
gtgtttcttc tccctgcaat gtatttcttt ctctaattcc ttccatttga tctttcatac 4140
acaatctggt tctgatgtat gttttttgga tgcacttttc aactccaaaa gacagagcta 4200
gttactttct tcctggtgct ccaagcactg tatttgtatc tgtattcaag ccctttgcaa 4260
tattgtactg gatcattatt tcacctctag gatggcttcc ccaggcaact tgtgttcacc 4320
cagagactac attttgtatc ttgttgacct ttgaacttcc accagtgtct aaaaataata 4380
tgtatgcaaa attacttgct atgagaatgt ataattaaac aatataaaaa ggagaagcaa 4440
ggagagaaac acaggtgtgt atttgtgttt gtgtgcttaa aaggcagtgt ggaaaaggaa 4500
gaaatgccat ttatagtgag gagacaaagt tatattacct cttatctggc ttttaaggag 4560
attttgctga gctaaaaatc ctatattcat agaaaagcct tacctgagtt gccaatacct 4620
caattcagtc tagcaggagt caatgggaaa aacccattgg agccaagtac actgactcaa 4680
tagggacttt ccattgggtt ttgcccagta cataaggtca atagggggtg agtcaacagg 4740
aaagtcccat tggagccaag tacattgagt caatagggac tttccaatgg gttttgccca 4800
gtacataagg tcaatgggag gtaagccaat gggtttttcc cattactgac atgtatactg 4860
agtcattagg gactttccaa tgggttttgc ccagtacata aggtcaatag gggtgaatca 4920
acaggaaagt cccattggag ccaagtacac tgagtcaata gggactttcc attgggtttt 4980
gcccagtaca aaaggtcaat agggggtgag tcaatgggtt tttcccatta ttggcacata 5040
cataaggtca ataggggtga ctagtggaga agagcatgct tgagggctga gtgcccctca 5100
gtgggcagag agcacatggc ccacagtccc tgagaagttg gggggagggg tgggcaattg 5160
aactggtgcc tagagaaggt ggggcttggg taaactggga aagtgatgtg gtgtactggc 5220
tccacctttt tccccagggt gggggagaac catatataag tgcagtagtc tctgtgaaca 5280
ttcaagcttc tgccttctcc ctcctgtgag tttggtaagt cactgactgt ctatgcctgg 5340
gaaagggtgg gcaggagatg gggcagtgca ggaaaagtgg cactatgaac cctgcagccc 5400
tagacaattg tactaacctt cttctctttc ctctcctgac aggttggtaa ccaagccacc 5460
atgggatggt ccctgatcct gctgtttctg gtggctgtgg ccaccagagt gctgtctgaa 5520
gtgcagctgg tggaaagtgg tggtggcctg gttcagcctg gtggctctct gagactgagc 5580
tgtgctgcct ctggcttcat tgtgtccagc aactacatga gctgggtcag acaggcccct 5640
ggcaaaggac tggaatgggt gtcagtgatc tacagtggtg gcagcaccta ctatgctgac 5700
tctgtgaagg gcagattcac catcagcaga cacaacagca agaacaccct gtacctgcag 5760
atgaacagcc tgagagctga ggacactgct gtgtactact gtgccagaga agcctatggc 5820
atggatgtgt ggggccaggg cacaacagtg actgtgtcct ctgccagcac aaagggcccc 5880
tctgtgtttc ctctggctcc cagcagcaag agcaccagtg gtggaacagc tgccctgggc 5940
tgtctggtca aggactactt tcctgagcct gtgacagtgt cctggaactc tggggctctg 6000
acatctgggg tgcacacatt ccctgcagtg ctgcagtcct ctggcctgta cagcctgtcc 6060
tctgtggtca cagtgcctag ctctagcctg ggcacccaga cctacatctg caatgtgaac 6120
cacaagccta gcaacaccaa ggtggacaag aaggctgagc ccaagagctg tgacaagacc 6180
cacacctgtc ctccatgtcc tgctccagag ctgcttggag gaccatcagt gtttctgttc 6240
cctccaaagc ctaaggacac cctgatgatc agcagaaccc ctgaagtgac ctgtgtggtg 6300
gttgatgtgt cccatgagga cccagaagtg aagttcaatt ggtatgtgga tggtgttgag 6360
gtgcacaatg ccaagaccaa gcctagagag gaacagtaca actccaccta cagagtggtt 6420
tctgtgctga cagtgctcca ccaggactgg ctgaatggca aagagtacaa gtgcaaggtg 6480
tccaacaagg ccctgcctgc tcctattgaa aagaccatct ccaaggccaa gggccagcct 6540
agggaacccc aggtttacac actgccacct agcagggatg agctgaccaa gaaccaggtg 6600
tccctgacat gcctggttaa gggcttctac ccctctgaca ttgctgtgga atgggagagc 6660
aatggccagc cagagaacaa ctacaagaca acccctcctg tgctggactc tgatggctca 6720
ttcttcctgt actccaagct gactgtggac aagtccagat ggcagcaggg caatgtcttt 6780
agctgctctg tgatgcatga ggccctgcac aaccactaca cacagaagtc cctgtctctg 6840
agccctggca agagaaagag aaggagtggc tctggggcca ccaacttcag cctgctgaaa 6900
caggctgggg atgttgaaga gaaccctgga cctatggact tccaggtgca gatcatcagc 6960
tttctgctta tctctgccag tgtgatcatg agcaggggag acattgtgat gacccagtct 7020
ccatccttcc tgagtgcctc tgtgggagac agagtgacca tcacctgtag agccagccag 7080
ggcatcagct cttacctggc ttggtatcag caaaagcctg gcaaggcccc taagctgctg 7140
atctatgctg cctccacact gcagtcaggg gtgccctcca gattttctgg ctctggatct 7200
ggcactgagt tcaccctgac catcagctcc ctgcagcctg aggactttgc cacctactac 7260
tgccagcagc tgaacagcta ccctccttac acctttggac agggcaccaa gctggaaatc 7320
aagaggacag tggctgctcc ttctgtgttc atcttcccac catcagatga acagctgaag 7380
agtggcacag cctctgttgt gtgcctgctc aacaacttct accctagaga agccaaggtg 7440
cagtggaaag tggacaatgc cctccagtct ggcaacagcc aagaatctgt gactgagcag 7500
gactccaagg acagcacata cagcctgagc agcacactga ccctgagcaa ggctgactat 7560
gagaagcaca aagtctatgc ctgtgaagtg acacaccagg gcctgtctag cccagtgacc 7620
aagtccttca acaggggaga gtgttgaaga tctacttctg gctaataaaa gatcagagct 7680
ctagtgatct gtgtgttggt tttttgtgtc tgcattctag caagtcaata tgttcacccc 7740
aaaaaagctg tttgttaact tgtcaacctc attctaaaat gtatatagaa gcccaaaaga 7800
caataacaaa aatattcttg tagaacaaaa tgggaaagaa tgttccacta aatatcaaga 7860
tttagagcaa agcatgagat gtgtggggat agacagtgag gctgataaaa tagagtagag 7920
ctcagaaaca gacccattga tatatgtaag tgacctatga aaaaaatatg gcattttaca 7980
atgggaaaat gatggtcttt ttctttttta gaaaaacagg gaaatatatt tatatgtaaa 8040
aaataaaagg gaacccatat gtcataccat acacacaaaa aaattccagt gaattataag 8100
tctaaatgga gaaggcaaaa ctttaaatct tttagaaaat aatatagaag catgccatca 8160
agacttcagt gtagagaaaa atttcttatg actcaaagtc ctaaccacaa agaaaagatt 8220
gttaattaga ttgcatgaat attaagactt atttttaaaa ttaaaaaacc attaagaaaa 8280
gtcaggccat agaatgacag aaaatatttg caacacccca gtaaagagaa ttgtaatatg 8340
cagattataa aaagaagtct tacaaatcag taaaaaataa aactagacaa aaatttgaac 8400
agatgaaaga gaaactctaa ataatcatta cacatgagaa actcaatctc agaaatcaga 8460
gaactatcat tgcatataca ctaaattaga gaaatattaa aaggctaagt aacatctgtg 8520
gcttaattaa tctagctcta gtgatcagca gttcaacctg ttgatagtat gtactaagct 8580
ctcatgttta atgtactaag ctctcatgtt taatgaacta aaccctcatg gctaatgtac 8640
taagctctca tggctaatgt actaagctct catgtttcat gtactaagct ctcatgtttg 8700
aacaataaaa ttaatataaa tcagcaactt aaatagcctc taaggtttta agttttataa 8760
gaaaaaaaag aatatataag gcttttaaag gttttaaggt ttcctaggtt atcctcatat 8820
gagctcttag aaaaactcat ccagcatcaa atgaaactgc aatttattca tatcaggatt 8880
atcaatacca tatttttgaa aaagtctttt ctgtaatgaa ggagaaaact cacccaggca 8940
gttccatagg atggcaagat cctggtatct gtctgcaatt ccaactcttc caacatcaat 9000
acaacctatt aatttcccct catcaaaaat aaggttatca agtgagaaat caccatgagt 9060
gaccactgaa tctggtgaga atggcaaaag attatgcatt tctttccaga cttgttcaac 9120
aggccagcca tttctctcat catcaaaatc actggcatca accaaaccat tattcattct 9180
tgattgggcc tgagccagtc taaatactct atcagagtta aaaggacaat tacaaacagg 9240
aatggaatgc aatcttctca ggaacactgc cagggcatca acaatatttt cacctgaatc 9300
aggatattct tccaatacct ggaatgctgt tttccctggg atggcagtgg tgagtaacca 9360
tgcatcatca ggagttctga taaaatgctt gatggttgga agaggcataa attcagtcag 9420
ccagtttagt ctgaccatct catctgtaac atcattggca acagaacctt tgccatgttt 9480
cagaaacaac tctggggcat ctggcttccc atacaatcta tagattgtgg cacctgattg 9540
cccaacatta tctctagccc atttataccc atataaatca gcatccatgt tggaatttaa 9600
tcttggcctg gagcaagagg tttctctttg aatatggctc atacatgtgc acctcctata 9660
gtgagttgta ttatactatg cagatatact atgccaatgt ttaattgtca g 9711
<210> 27
<211> 9762
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic
<400> 27
cactatgtgt taattaaaat tatctctaag gcatgtgaac tggctgtctt ggttttcatc 60
tgtacttcat ctgctacctc tgtgacctga aacatattta taattccatt aagctgtgca 120
tatgatagat ttatcatatg tattttcctt aaaggatttt tgtaagaact aattgaattg 180
atacctgtaa agtctttatc acactaccca ataaataata aatctctttg ttcagctctc 240
tgtttctata aatatgtacc agttttattg tttttagtgg tagtgatttt attctctttc 300
tatatatata cacacacatg tgtgcattca taaatatata caatttttat gaataaaaaa 360
ttattagcaa tcaatattga aaaccactga tttttgttta tgtgagcaaa cagcagatta 420
aaaggaattt gaattctcat agctagcagg agtcaatggg aaaaacccat tggagccaag 480
tacactgact caatagggac tttccattgg gttttgccca gtacataagg tcaatagggg 540
gtgagtcaac aggaaagtcc cattggagcc aagtacattg agtcaatagg gactttccaa 600
tgggttttgc ccagtacata aggtcaatgg gaggtaagcc aatgggtttt tcccattact 660
gacatgtata ctgagtcatt agggactttc caatgggttt tgcccagtac ataaggtcaa 720
taggggtgaa tcaacaggaa agtcccattg gagccaagta cactgagtca atagggactt 780
tccattgggt tttgcccagt acaaaaggtc aatagggggt gagtcaatgg gtttttccca 840
ttattggcac atacataagg tcaatagggg tgactagtgg agaagagcat gcttgagggc 900
tgagtgcccc tcagtgggca gagagcacat ggcccacagt ccctgagaag ttggggggag 960
gggtgggcaa ttgaactggt gcctagagaa ggtggggctt gggtaaactg ggaaagtgat 1020
gtggtgtact ggctccacct ttttccccag ggtgggggag aaccatatat aagtgcagta 1080
gtctctgtga acattcaagc ttctgccttc tccctcctgt gagtttggta agtcactgac 1140
tgtctatgcc tgggaaaggg tgggcaggag atggggcagt gcaggaaaag tggcactatg 1200
aaccctgcag ccctagacaa ttgtactaac cttcttctct ttcctctcct gacaggttgg 1260
taaccaagcc accatgggat ggtccctgat cctgctgttt ctggtggctg tggccaccag 1320
agtgctgtct caggttcagc tggtgcagtc tggggctgaa gtgaagaaac ctggggcctc 1380
tgtgaaggtg tcctgcaagg cttctggcta cacattcaca ggctactaca tgcactgggt 1440
cagacaggcc cctggacagg gacttgagtg gatgggcaga atcaacccca acagtggtgg 1500
caccaactat gcccagaaat tccagggcag agtgaccatg accagagaca ccagcatcag 1560
cacagcctac atggaactga gcaggcttag gagtgatgac actgctgtgt actactgtgc 1620
cagagtgccc tactgcagca gcacctcttg tcacagagac tggtactttg acctgtgggg 1680
cagaggcacc ctggtcacag ttagctctgc cagcacaaag ggcccctctg tgtttcctct 1740
ggctcccagc agcaagagca ccagtggtgg aacagctgcc ctgggctgtc tggtcaagga 1800
ctactttcct gagcctgtga cagtgtcctg gaactctggg gctctgacat ctggggtgca 1860
cacattccct gctgtgctgc agtcctctgg cctgtacagc ctgtcctctg tggtcactgt 1920
gcctagctct agcctgggca cccagaccta catctgcaat gtgaaccaca agcctagcaa 1980
caccaaggtg gacaagaagg ctgagcccaa gagctgtgat aagacccaca cctgtcctcc 2040
atgtcctgct ccagagctgc ttggaggacc atcagtgttt ctgttccctc caaagcctaa 2100
ggacaccctg atgatcagca gaacccctga agtgacctgt gtggtggtgg atgtgtccca 2160
tgaggaccca gaagtgaagt tcaattggta tgtggatggt gttgaggtgc acaatgccaa 2220
gaccaagcct agagaggaac agtacaacag cacctacaga gtggtgtctg tgctgacagt 2280
gctgcaccag gactggctga atggcaaaga gtacaagtgc aaggtgtcca acaaggccct 2340
gcctgctcct attgaaaaga ccatcagcaa ggccaagggc cagcctaggg aaccccaagt 2400
gtataccctg cctcctagca gagatgagct gaccaagaac caggtgtccc tgacatgcct 2460
ggttaagggc ttctacccct ctgacattgc tgtggaatgg gagagcaatg gccagcctga 2520
gaacaactac aagaccacac ctcctgtgct ggactctgat ggctcattct tcctgtactc 2580
caagctgact gtggacaagt ccagatggca gcaaggcaat gtgttcagct gctctgtgat 2640
gcatgaggcc ctgcacaacc actacacaca gaagtctctg tctctgagcc ctggcaagag 2700
aaagagaagg agtggctctg gggccaccaa cttcagcctg ctgaaacagg ctggggatgt 2760
tgaagagaac cctggaccta tggacttcca ggtgcagatc atcagctttc tgcttatctc 2820
tgccagtgtg atcatgagca ggggagacat ccagatgaca cagagccctc tgagcctgcc 2880
agtgacacct ggggaacctg ccagcatctc ttgcagaagc tctcagagcc tcctggattc 2940
tgatgatggc aacacctacc tggactggta tctgcagaag cctggccagt ctcctcagct 3000
gctgatctac accctgagct acagagccag tggggtgcca gacagattct ctggctctgg 3060
atctggcact gacttcacac tgaagattag cagagtggaa gctgaggatg tgggagtcta 3120
ctactgtatg cagaggattg agttccctct gacttttggt ggtggtacaa aggtggaaat 3180
caagaggaca gtggctgctc cttctgtgtt catcttccca ccatctgatg agcagctcaa 3240
gagtggcaca gcctctgttg tgtgtctgct gaacaacttc taccctaggg aagccaaggt 3300
gcagtggaaa gtggacaatg ccctccagtc tggcaacagc caagagagtg tgacagaaca 3360
ggacagcaag gactccacct acagcctgag cagcaccctg acactgagca aggctgacta 3420
tgagaagcac aaagtctatg cctgtgaagt gacacaccag ggactgagca gccctgtgac 3480
caagagcttc aacaggggag agtgcagctg aagatctact tctggctaat aaaagatcag 3540
agctctagtg atctgtgtgt tggttttttg tgtctgcatt ctagcagagc cccactgtgt 3600
tcatcttaca gatggaaata ctgacattca gaggagttag ttaacttgcc taggtgattc 3660
agctaataag tgcaagaaag atttcaatcc aaggtgattt gattctgaag cctgtgctaa 3720
tcacattaca ccaagctaca acttcattta taaataataa gtcagctttc aagggccttt 3780
caggtgtcct gcacttctac aagctgtgcc atttagtgaa cacaaaatga gccttctgat 3840
gaagtagtct tttcattatt tcagatatta gaacactaaa attcttagct gccagctgat 3900
tgaaggctgg gacaaaattc aaacatgcat ctacaacaat atatatctca atgttagtct 3960
ccaaattcta ttgacttcaa ctcaagagaa tataaagagc tagtctttat acactcttta 4020
aggtatgata tcatctggaa agtaacaaaa ttgatgcaaa tttgaatgaa ctttatcatg 4080
gtgtatttac acaatgtgtt tcttctccct gcaatgtatt tctttctcta attccttcca 4140
tttgatcttt catacacaat ctggttctga tgtatgtttt ttggatgcac ttttcaactc 4200
caaaagacag agctagttac tttcttcctg gtgctccaag cactgtattt gtatctgtat 4260
tcaagccctt tgcaatattg tactggatca ttatttcacc tctaggatgg cttccccagg 4320
caacttgtgt tcacccagag actacatttt gtatcttgtt gacctttgaa cttccaccag 4380
tgtctaaaaa taatatgtat gcaaaattac ttgctatgag aatgtataat taaacaatat 4440
aaaaaggaga agcaaggaga gaaacacagg tgtgtatttg tgtttgtgtg cttaaaaggc 4500
agtgtggaaa aggaagaaat gccatttata gtgaggagac aaagttatat tacctcttat 4560
ctggctttta aggagatttt gctgagctaa aaatcctata ttcatagaaa agccttacct 4620
gagttgccaa tacctcaatt cagtctagca ggagtcaatg ggaaaaaccc attggagcca 4680
agtacactga ctcaataggg actttccatt gggttttgcc cagtacataa ggtcaatagg 4740
gggtgagtca acaggaaagt cccattggag ccaagtacat tgagtcaata gggactttcc 4800
aatgggtttt gcccagtaca taaggtcaat gggaggtaag ccaatgggtt tttcccatta 4860
ctgacatgta tactgagtca ttagggactt tccaatgggt tttgcccagt acataaggtc 4920
aataggggtg aatcaacagg aaagtcccat tggagccaag tacactgagt caatagggac 4980
tttccattgg gttttgccca gtacaaaagg tcaatagggg gtgagtcaat gggtttttcc 5040
cattattggc acatacataa ggtcaatagg ggtgactagt ggagaagagc atgcttgagg 5100
gctgagtgcc cctcagtggg cagagagcac atggcccaca gtccctgaga agttgggggg 5160
aggggtgggc aattgaactg gtgcctagag aaggtggggc ttgggtaaac tgggaaagtg 5220
atgtggtgta ctggctccac ctttttcccc agggtggggg agaaccatat ataagtgcag 5280
tagtctctgt gaacattcaa gcttctgcct tctccctcct gtgagtttgg taagtcactg 5340
actgtctatg cctgggaaag ggtgggcagg agatggggca gtgcaggaaa agtggcacta 5400
tgaaccctgc agccctagac aattgtacta accttcttct ctttcctctc ctgacaggtt 5460
ggtaaccaag ccaccatgag cagcagctct tggctgctgc tgagtctggt ggctgtgaca 5520
gctgcccaga gcaccattga ggaacaggcc aagaccttcc tggacaagtt caaccatgag 5580
gctgaggacc tgttctacca gagcagcctg gccagctgga actacaacac caacatcact 5640
gaagagaatg tgcagaacat gaacaatgct ggggacaagt ggagtgcctt cctgaaagag 5700
cagagcacac tggcccagat gtaccctctg caagagatcc agaacctgac agtgaagctc 5760
cagctccagg ctctccagca gaatggcagc tctgtgctgt ctgaggacaa gagcaagaga 5820
ctgaacacca tcctgaacac aatgagcacc atctacagca caggcaaagt gtgcaaccct 5880
gacaaccctc aagagtgcct gctgctggaa cctggcctga atgagatcat ggccaacagc 5940
ctggactaca atgagagact gtgggcctgg gagtcttgga ggagtgaagt gggaaagcag 6000
ctgaggcccc tgtatgagga atatgtggtg ctgaagaatg agatggccag ggccaaccac 6060
tatgaggact atggggatta ttggagggga gactatgaag tgaatggtgt tgatggctat 6120
gactacagca ggggccagct gattgaggat gtggaacaca cctttgagga aatcaagccc 6180
ctctatgagc acctccatgc ctatgtcaga gccaagctga tgaatgctta ccccagctac 6240
atcagcccca ttggctgcct gcctgctcat ctgctgggag acatgtgggg cagattctgg 6300
accaacctgt acagcctgac tgtgcccttt ggccagaaac ctaacattga tgtgacagat 6360
gccatggtgg atcaggcctg ggatgcccag agaatcttca aagaggctga gaagttcttt 6420
gtgtctgtgg ggctgcccaa catgacccaa ggcttttggg agaactccat gctgacagac 6480
cctggcaatg tgcaaaaggc tgtgtgtcac cccacagcct gggaccttgg caagggagac 6540
ttcagaatcc tgatgtgcac caaagtgaca atggatgact ttctgacagc tcaccatgag 6600
atgggccaca tccagtatga catggcctat gctgcccagc ctttcctgct gagaaatggg 6660
gccaatgagg gcttccatga ggcagtggga gagatcatga gcctgtctgc tgccacacct 6720
aagcacctga agtccattgg cctgctgagc cctgacttcc aagaggacaa tgagacagag 6780
atcaacttcc tgctcaagca ggccctgacc attgtgggca cactgccctt cacctacatg 6840
ctggaaaagt ggagatggat ggtctttaag ggagaaatcc ccaaggacca gtggatgaag 6900
aaatggtggg agatgaagag ggaaattgtg ggagttgtgg aacctgtgcc acatgatgag 6960
acatactgtg accctgccag cctgttccat gtgtccaatg actactcctt cattaggtac 7020
tacaccagga cactgtacca gttccagttt caagaggctc tgtgtcaggc tgctaaacat 7080
gagggcccac tgcacaagtg tgacatcagc aactccacag aggctggaca gaaactgttc 7140
aacatgctga gactgggcaa gtctgagcct tggactctgg ccctggaaaa tgttgtggga 7200
gccaagaata tgaatgtcag acccctgctg aactactttg agcccctgtt cacctggctg 7260
aaggaccaga acaagaacag ctttgttggc tggtccacag actggtcccc atatgctgac 7320
cagagcatca aagtcagaat cagcctgaag agtgccctgg gagataaggc ctatgagtgg 7380
aatgataatg agatgtacct gttcaggtcc tctgtggctt atgctatgag acagtacttt 7440
ctgaaagtga agaaccagat gatcctgttt ggagaagagg atgtcagagt ggccaacctg 7500
aagcctagaa tcagcttcaa cttctttgtg acagccccta agaatgtgtc tgacatcatc 7560
cccagaacag aggtggaaaa ggccatcaga atgagcaggt ccaggatcaa tgatgccttc 7620
aggctcaatg acaactccct ggaatttctg ggcattcagc ccacactggg ccctccaaat 7680
cagcctcctg tgtcctaaag atctacttct ggctaataaa agatcagagc tctagtgatc 7740
tgtgtgttgg ttttttgtgt ctgcattcta gcaagtcaat atgttcaccc caaaaaagct 7800
gtttgttaac ttgtcaacct cattctaaaa tgtatataga agcccaaaag acaataacaa 7860
aaatattctt gtagaacaaa atgggaaaga atgttccact aaatatcaag atttagagca 7920
aagcatgaga tgtgtgggga tagacagtga ggctgataaa atagagtaga gctcagaaac 7980
agacccattg atatatgtaa gtgacctatg aaaaaaatat ggcattttac aatgggaaaa 8040
tgatggtctt tttctttttt agaaaaacag ggaaatatat ttatatgtaa aaaataaaag 8100
ggaacccata tgtcatacca tacacacaaa aaaattccag tgaattataa gtctaaatgg 8160
agaaggcaaa actttaaatc ttttagaaaa taatatagaa gcatgccatc aagacttcag 8220
tgtagagaaa aatttcttat gactcaaagt cctaaccaca aagaaaagat tgttaattag 8280
attgcatgaa tattaagact tatttttaaa attaaaaaac cattaagaaa agtcaggcca 8340
tagaatgaca gaaaatattt gcaacacccc agtaaagaga attgtaatat gcagattata 8400
aaaagaagtc ttacaaatca gtaaaaaata aaactagaca aaaatttgaa cagatgaaag 8460
agaaactcta aataatcatt acacatgaga aactcaatct cagaaatcag agaactatca 8520
ttgcatatac actaaattag agaaatatta aaaggctaag taacatctgt ggcttaatta 8580
atctagctct agtgatcagc agttcaacct gttgatagta tgtactaagc tctcatgttt 8640
aatgtactaa gctctcatgt ttaatgaact aaaccctcat ggctaatgta ctaagctctc 8700
atggctaatg tactaagctc tcatgtttca tgtactaagc tctcatgttt gaacaataaa 8760
attaatataa atcagcaact taaatagcct ctaaggtttt aagttttata agaaaaaaaa 8820
gaatatataa ggcttttaaa ggttttaagg tttcctaggt tatcctcata tgagctctta 8880
gaaaaactca tccagcatca aatgaaactg caatttattc atatcaggat tatcaatacc 8940
atatttttga aaaagtcttt tctgtaatga aggagaaaac tcacccaggc agttccatag 9000
gatggcaaga tcctggtatc tgtctgcaat tccaactctt ccaacatcaa tacaacctat 9060
taatttcccc tcatcaaaaa taaggttatc aagtgagaaa tcaccatgag tgaccactga 9120
atctggtgag aatggcaaaa gattatgcat ttctttccag acttgttcaa caggccagcc 9180
atttctctca tcatcaaaat cactggcatc aaccaaacca ttattcattc ttgattgggc 9240
ctgagccagt ctaaatactc tatcagagtt aaaaggacaa ttacaaacag gaatggaatg 9300
caatcttctc aggaacactg ccagggcatc aacaatattt tcacctgaat caggatattc 9360
ttccaatacc tggaatgctg ttttccctgg gatggcagtg gtgagtaacc atgcatcatc 9420
aggagttctg ataaaatgct tgatggttgg aagaggcata aattcagtca gccagtttag 9480
tctgaccatc tcatctgtaa catcattggc aacagaacct ttgccatgtt tcagaaacaa 9540
ctctggggca tctggcttcc catacaatct atagattgtg gcacctgatt gcccaacatt 9600
atctctagcc catttatacc catataaatc agcatccatg ttggaattta atcttggcct 9660
ggagcaagag gtttctcttt gaatatggct catacatgtg cacctcctat agtgagttgt 9720
attatactat gcagatatac tatgccaatg tttaattgtc ag 9762
<210> 28
<211> 9762
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic
<400> 28
cactatgtgt taattaaaat tatctctaag gcatgtgaac tggctgtctt ggttttcatc 60
tgtacttcat ctgctacctc tgtgacctga aacatattta taattccatt aagctgtgca 120
tatgatagat ttatcatatg tattttcctt aaaggatttt tgtaagaact aattgaattg 180
atacctgtaa agtctttatc acactaccca ataaataata aatctctttg ttcagctctc 240
tgtttctata aatatgtacc agttttattg tttttagtgg tagtgatttt attctctttc 300
tatatatata cacacacatg tgtgcattca taaatatata caatttttat gaataaaaaa 360
ttattagcaa tcaatattga aaaccactga tttttgttta tgtgagcaaa cagcagatta 420
aaaggaattt gaattctcat agctagcagg agtcaatggg aaaaacccat tggagccaag 480
tacactgact caatagggac tttccattgg gttttgccca gtacataagg tcaatagggg 540
gtgagtcaac aggaaagtcc cattggagcc aagtacattg agtcaatagg gactttccaa 600
tgggttttgc ccagtacata aggtcaatgg gaggtaagcc aatgggtttt tcccattact 660
gacatgtata ctgagtcatt agggactttc caatgggttt tgcccagtac ataaggtcaa 720
taggggtgaa tcaacaggaa agtcccattg gagccaagta cactgagtca atagggactt 780
tccattgggt tttgcccagt acaaaaggtc aatagggggt gagtcaatgg gtttttccca 840
ttattggcac atacataagg tcaatagggg tgactagtgg agaagagcat gcttgagggc 900
tgagtgcccc tcagtgggca gagagcacat ggcccacagt ccctgagaag ttggggggag 960
gggtgggcaa ttgaactggt gcctagagaa ggtggggctt gggtaaactg ggaaagtgat 1020
gtggtgtact ggctccacct ttttccccag ggtgggggag aaccatatat aagtgcagta 1080
gtctctgtga acattcaagc ttctgccttc tccctcctgt gagtttggta agtcactgac 1140
tgtctatgcc tgggaaaggg tgggcaggag atggggcagt gcaggaaaag tggcactatg 1200
aaccctgcag ccctagacaa ttgtactaac cttcttctct ttcctctcct gacaggttgg 1260
taaccaagcc accatgagca gcagctcttg gctgctgctg agtctggtgg ctgtgacagc 1320
tgcccagagc accattgagg aacaggccaa gaccttcctg gacaagttca accatgaggc 1380
tgaggacctg ttctaccaga gcagcctggc cagctggaac tacaacacca acatcactga 1440
agagaatgtg cagaacatga acaatgctgg ggacaagtgg agtgccttcc tgaaagagca 1500
gagcacactg gcccagatgt accctctgca agagatccag aacctgacag tgaagctcca 1560
gctccaggct ctccagcaga atggcagctc tgtgctgtct gaggacaaga gcaagagact 1620
gaacaccatc ctgaacacaa tgagcaccat ctacagcaca ggcaaagtgt gcaaccctga 1680
caaccctcaa gagtgcctgc tgctggaacc tggcctgaat gagatcatgg ccaacagcct 1740
ggactacaat gagagactgt gggcctggga gtcttggagg agtgaagtgg gaaagcagct 1800
gaggcccctg tatgaggaat atgtggtgct gaagaatgag atggccaggg ccaaccacta 1860
tgaggactat ggggattatt ggaggggaga ctatgaagtg aatggtgttg atggctatga 1920
ctacagcagg ggccagctga ttgaggatgt ggaacacacc tttgaggaaa tcaagcccct 1980
ctatgagcac ctccatgcct atgtcagagc caagctgatg aatgcttacc ccagctacat 2040
cagccccatt ggctgcctgc ctgctcatct gctgggagac atgtggggca gattctggac 2100
caacctgtac agcctgactg tgccctttgg ccagaaacct aacattgatg tgacagatgc 2160
catggtggat caggcctggg atgcccagag aatcttcaaa gaggctgaga agttctttgt 2220
gtctgtgggg ctgcccaaca tgacccaagg cttttgggag aactccatgc tgacagaccc 2280
tggcaatgtg caaaaggctg tgtgtcaccc cacagcctgg gaccttggca agggagactt 2340
cagaatcctg atgtgcacca aagtgacaat ggatgacttt ctgacagctc accatgagat 2400
gggccacatc cagtatgaca tggcctatgc tgcccagcct ttcctgctga gaaatggggc 2460
caatgagggc ttccatgagg cagtgggaga gatcatgagc ctgtctgctg ccacacctaa 2520
gcacctgaag tccattggcc tgctgagccc tgacttccaa gaggacaatg agacagagat 2580
caacttcctg ctcaagcagg ccctgaccat tgtgggcaca ctgcccttca cctacatgct 2640
ggaaaagtgg agatggatgg tctttaaggg agaaatcccc aaggaccagt ggatgaagaa 2700
atggtgggag atgaagaggg aaattgtggg agttgtggaa cctgtgccac atgatgagac 2760
atactgtgac cctgccagcc tgttccatgt gtccaatgac tactccttca ttaggtacta 2820
caccaggaca ctgtaccagt tccagtttca agaggctctg tgtcaggctg ctaaacatga 2880
gggcccactg cacaagtgtg acatcagcaa ctccacagag gctggacaga aactgttcaa 2940
catgctgaga ctgggcaagt ctgagccttg gactctggcc ctggaaaatg ttgtgggagc 3000
caagaatatg aatgtcagac ccctgctgaa ctactttgag cccctgttca cctggctgaa 3060
ggaccagaac aagaacagct ttgttggctg gtccacagac tggtccccat atgctgacca 3120
gagcatcaaa gtcagaatca gcctgaagag tgccctggga gataaggcct atgagtggaa 3180
tgataatgag atgtacctgt tcaggtcctc tgtggcttat gctatgagac agtactttct 3240
gaaagtgaag aaccagatga tcctgtttgg agaagaggat gtcagagtgg ccaacctgaa 3300
gcctagaatc agcttcaact tctttgtgac agcccctaag aatgtgtctg acatcatccc 3360
cagaacagag gtggaaaagg ccatcagaat gagcaggtcc aggatcaatg atgccttcag 3420
gctcaatgac aactccctgg aatttctggg cattcagccc acactgggcc ctccaaatca 3480
gcctcctgtg tcctaaagat ctacttctgg ctaataaaag atcagagctc tagtgatctg 3540
tgtgttggtt ttttgtgtct gcattctagc agagccccac tgtgttcatc ttacagatgg 3600
aaatactgac attcagagga gttagttaac ttgcctaggt gattcagcta ataagtgcaa 3660
gaaagatttc aatccaaggt gatttgattc tgaagcctgt gctaatcaca ttacaccaag 3720
ctacaacttc atttataaat aataagtcag ctttcaaggg cctttcaggt gtcctgcact 3780
tctacaagct gtgccattta gtgaacacaa aatgagcctt ctgatgaagt agtcttttca 3840
ttatttcaga tattagaaca ctaaaattct tagctgccag ctgattgaag gctgggacaa 3900
aattcaaaca tgcatctaca acaatatata tctcaatgtt agtctccaaa ttctattgac 3960
ttcaactcaa gagaatataa agagctagtc tttatacact ctttaaggta tgatatcatc 4020
tggaaagtaa caaaattgat gcaaatttga atgaacttta tcatggtgta tttacacaat 4080
gtgtttcttc tccctgcaat gtatttcttt ctctaattcc ttccatttga tctttcatac 4140
acaatctggt tctgatgtat gttttttgga tgcacttttc aactccaaaa gacagagcta 4200
gttactttct tcctggtgct ccaagcactg tatttgtatc tgtattcaag ccctttgcaa 4260
tattgtactg gatcattatt tcacctctag gatggcttcc ccaggcaact tgtgttcacc 4320
cagagactac attttgtatc ttgttgacct ttgaacttcc accagtgtct aaaaataata 4380
tgtatgcaaa attacttgct atgagaatgt ataattaaac aatataaaaa ggagaagcaa 4440
ggagagaaac acaggtgtgt atttgtgttt gtgtgcttaa aaggcagtgt ggaaaaggaa 4500
gaaatgccat ttatagtgag gagacaaagt tatattacct cttatctggc ttttaaggag 4560
attttgctga gctaaaaatc ctatattcat agaaaagcct tacctgagtt gccaatacct 4620
caattcagtc tagcaggagt caatgggaaa aacccattgg agccaagtac actgactcaa 4680
tagggacttt ccattgggtt ttgcccagta cataaggtca atagggggtg agtcaacagg 4740
aaagtcccat tggagccaag tacattgagt caatagggac tttccaatgg gttttgccca 4800
gtacataagg tcaatgggag gtaagccaat gggtttttcc cattactgac atgtatactg 4860
agtcattagg gactttccaa tgggttttgc ccagtacata aggtcaatag gggtgaatca 4920
acaggaaagt cccattggag ccaagtacac tgagtcaata gggactttcc attgggtttt 4980
gcccagtaca aaaggtcaat agggggtgag tcaatgggtt tttcccatta ttggcacata 5040
cataaggtca ataggggtga ctagtggaga agagcatgct tgagggctga gtgcccctca 5100
gtgggcagag agcacatggc ccacagtccc tgagaagttg gggggagggg tgggcaattg 5160
aactggtgcc tagagaaggt ggggcttggg taaactggga aagtgatgtg gtgtactggc 5220
tccacctttt tccccagggt gggggagaac catatataag tgcagtagtc tctgtgaaca 5280
ttcaagcttc tgccttctcc ctcctgtgag tttggtaagt cactgactgt ctatgcctgg 5340
gaaagggtgg gcaggagatg gggcagtgca ggaaaagtgg cactatgaac cctgcagccc 5400
tagacaattg tactaacctt cttctctttc ctctcctgac aggttggtaa ccaagccacc 5460
atgggatggt ccctgatcct gctgtttctg gtggctgtgg ccaccagagt gctgtctcag 5520
gttcagctgg tgcagtctgg ggctgaagtg aagaaacctg gggcctctgt gaaggtgtcc 5580
tgcaaggctt ctggctacac attcacaggc tactacatgc actgggtcag acaggcccct 5640
ggacagggac ttgagtggat gggcagaatc aaccccaaca gtggtggcac caactatgcc 5700
cagaaattcc agggcagagt gaccatgacc agagacacca gcatcagcac agcctacatg 5760
gaactgagca ggcttaggag tgatgacact gctgtgtact actgtgccag agtgccctac 5820
tgcagcagca cctcttgtca cagagactgg tactttgacc tgtggggcag aggcaccctg 5880
gtcacagtta gctctgccag cacaaagggc ccctctgtgt ttcctctggc tcccagcagc 5940
aagagcacca gtggtggaac agctgccctg ggctgtctgg tcaaggacta ctttcctgag 6000
cctgtgacag tgtcctggaa ctctggggct ctgacatctg gggtgcacac attccctgct 6060
gtgctgcagt cctctggcct gtacagcctg tcctctgtgg tcactgtgcc tagctctagc 6120
ctgggcaccc agacctacat ctgcaatgtg aaccacaagc ctagcaacac caaggtggac 6180
aagaaggctg agcccaagag ctgtgataag acccacacct gtcctccatg tcctgctcca 6240
gagctgcttg gaggaccatc agtgtttctg ttccctccaa agcctaagga caccctgatg 6300
atcagcagaa cccctgaagt gacctgtgtg gtggtggatg tgtcccatga ggacccagaa 6360
gtgaagttca attggtatgt ggatggtgtt gaggtgcaca atgccaagac caagcctaga 6420
gaggaacagt acaacagcac ctacagagtg gtgtctgtgc tgacagtgct gcaccaggac 6480
tggctgaatg gcaaagagta caagtgcaag gtgtccaaca aggccctgcc tgctcctatt 6540
gaaaagacca tcagcaaggc caagggccag cctagggaac cccaagtgta taccctgcct 6600
cctagcagag atgagctgac caagaaccag gtgtccctga catgcctggt taagggcttc 6660
tacccctctg acattgctgt ggaatgggag agcaatggcc agcctgagaa caactacaag 6720
accacacctc ctgtgctgga ctctgatggc tcattcttcc tgtactccaa gctgactgtg 6780
gacaagtcca gatggcagca aggcaatgtg ttcagctgct ctgtgatgca tgaggccctg 6840
cacaaccact acacacagaa gtctctgtct ctgagccctg gcaagagaaa gagaaggagt 6900
ggctctgggg ccaccaactt cagcctgctg aaacaggctg gggatgttga agagaaccct 6960
ggacctatgg acttccaggt gcagatcatc agctttctgc ttatctctgc cagtgtgatc 7020
atgagcaggg gagacatcca gatgacacag agccctctga gcctgccagt gacacctggg 7080
gaacctgcca gcatctcttg cagaagctct cagagcctcc tggattctga tgatggcaac 7140
acctacctgg actggtatct gcagaagcct ggccagtctc ctcagctgct gatctacacc 7200
ctgagctaca gagccagtgg ggtgccagac agattctctg gctctggatc tggcactgac 7260
ttcacactga agattagcag agtggaagct gaggatgtgg gagtctacta ctgtatgcag 7320
aggattgagt tccctctgac ttttggtggt ggtacaaagg tggaaatcaa gaggacagtg 7380
gctgctcctt ctgtgttcat cttcccacca tctgatgagc agctcaagag tggcacagcc 7440
tctgttgtgt gtctgctgaa caacttctac cctagggaag ccaaggtgca gtggaaagtg 7500
gacaatgccc tccagtctgg caacagccaa gagagtgtga cagaacagga cagcaaggac 7560
tccacctaca gcctgagcag caccctgaca ctgagcaagg ctgactatga gaagcacaaa 7620
gtctatgcct gtgaagtgac acaccaggga ctgagcagcc ctgtgaccaa gagcttcaac 7680
aggggagagt gcagctgaag atctacttct ggctaataaa agatcagagc tctagtgatc 7740
tgtgtgttgg ttttttgtgt ctgcattcta gcaagtcaat atgttcaccc caaaaaagct 7800
gtttgttaac ttgtcaacct cattctaaaa tgtatataga agcccaaaag acaataacaa 7860
aaatattctt gtagaacaaa atgggaaaga atgttccact aaatatcaag atttagagca 7920
aagcatgaga tgtgtgggga tagacagtga ggctgataaa atagagtaga gctcagaaac 7980
agacccattg atatatgtaa gtgacctatg aaaaaaatat ggcattttac aatgggaaaa 8040
tgatggtctt tttctttttt agaaaaacag ggaaatatat ttatatgtaa aaaataaaag 8100
ggaacccata tgtcatacca tacacacaaa aaaattccag tgaattataa gtctaaatgg 8160
agaaggcaaa actttaaatc ttttagaaaa taatatagaa gcatgccatc aagacttcag 8220
tgtagagaaa aatttcttat gactcaaagt cctaaccaca aagaaaagat tgttaattag 8280
attgcatgaa tattaagact tatttttaaa attaaaaaac cattaagaaa agtcaggcca 8340
tagaatgaca gaaaatattt gcaacacccc agtaaagaga attgtaatat gcagattata 8400
aaaagaagtc ttacaaatca gtaaaaaata aaactagaca aaaatttgaa cagatgaaag 8460
agaaactcta aataatcatt acacatgaga aactcaatct cagaaatcag agaactatca 8520
ttgcatatac actaaattag agaaatatta aaaggctaag taacatctgt ggcttaatta 8580
atctagctct agtgatcagc agttcaacct gttgatagta tgtactaagc tctcatgttt 8640
aatgtactaa gctctcatgt ttaatgaact aaaccctcat ggctaatgta ctaagctctc 8700
atggctaatg tactaagctc tcatgtttca tgtactaagc tctcatgttt gaacaataaa 8760
attaatataa atcagcaact taaatagcct ctaaggtttt aagttttata agaaaaaaaa 8820
gaatatataa ggcttttaaa ggttttaagg tttcctaggt tatcctcata tgagctctta 8880
gaaaaactca tccagcatca aatgaaactg caatttattc atatcaggat tatcaatacc 8940
atatttttga aaaagtcttt tctgtaatga aggagaaaac tcacccaggc agttccatag 9000
gatggcaaga tcctggtatc tgtctgcaat tccaactctt ccaacatcaa tacaacctat 9060
taatttcccc tcatcaaaaa taaggttatc aagtgagaaa tcaccatgag tgaccactga 9120
atctggtgag aatggcaaaa gattatgcat ttctttccag acttgttcaa caggccagcc 9180
atttctctca tcatcaaaat cactggcatc aaccaaacca ttattcattc ttgattgggc 9240
ctgagccagt ctaaatactc tatcagagtt aaaaggacaa ttacaaacag gaatggaatg 9300
caatcttctc aggaacactg ccagggcatc aacaatattt tcacctgaat caggatattc 9360
ttccaatacc tggaatgctg ttttccctgg gatggcagtg gtgagtaacc atgcatcatc 9420
aggagttctg ataaaatgct tgatggttgg aagaggcata aattcagtca gccagtttag 9480
tctgaccatc tcatctgtaa catcattggc aacagaacct ttgccatgtt tcagaaacaa 9540
ctctggggca tctggcttcc catacaatct atagattgtg gcacctgatt gcccaacatt 9600
atctctagcc catttatacc catataaatc agcatccatg ttggaattta atcttggcct 9660
ggagcaagag gtttctcttt gaatatggct catacatgtg cacctcctat agtgagttgt 9720
attatactat gcagatatac tatgccaatg tttaattgtc ag 9762
<210> 29
<211> 13521
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic
<400> 29
cactatgtga attggaattc tcatagctag caggagtcaa tgggaaaaac ccattggagc 60
caagtacact gactcaatag ggactttcca ttgggttttg cccagtacat aaggtcaata 120
gggggtgagt caacaggaaa gtcccattgg agccaagtac attgagtcaa tagggacttt 180
ccaatgggtt ttgcccagta cataaggtca atgggaggta agccaatggg tttttcccat 240
tactgacatg tatactgagt cattagggac tttccaatgg gttttgccca gtacataagg 300
tcaatagggg tgaatcaaca ggaaagtccc attggagcca agtacactga gtcaataggg 360
actttccatt gggttttgcc cagtacaaaa ggtcaatagg gggtgagtca atgggttttt 420
cccattattg gcacatacat aaggtcaata ggggtgacta gtggagaaga gcatgcttga 480
gggctgagtg cccctcagtg ggcagagagc acatggccca cagtccctga gaagttgggg 540
ggaggggtgg gcaattgaac tggtgcctag agaaggtggg gcttgggtaa actgggaaag 600
tgatgtggtg tactggctcc acctttttcc ccagggtggg ggagaaccat atataagtgc 660
agtagtctct gtgaacattc aagcttctgc cttctccctc ctgtgagttt ggtaagtcac 720
tgactgtcta tgcctgggaa agggtgggca ggagatgggg cagtgcagga aaagtggcac 780
tatgaaccct gcagccctag acaattgtac taaccttctt ctctttcctc tcctgacagg 840
ttggtaacca tgggatggtc cctgatcctg ctgtttctgg tggctgtggc caccagagtg 900
ctgtctcagg ttcagctggt gcagtctggg gctgaagtga agaaacctgg ggcctctgtg 960
aaggtgtcct gcaaggcttc tggctacaca ttcacaggct actacatgca ctgggtcaga 1020
caggcccctg gacagggact tgagtggatg ggcagaatca accccaacag tggtggcacc 1080
aactatgccc agaaattcca gggcagagtg accatgacca gagacaccag catcagcaca 1140
gcctacatgg aactgagcag gcttaggagt gatgacactg ctgtgtacta ctgtgccaga 1200
gtgccctact gcagcagcac ctcttgtcac agagactggt actttgacct gtggggcaga 1260
ggcaccctgg tcacagttag ctctgccagc acaaagggcc cctctgtgtt tcctctggct 1320
cccagcagca agagcaccag tggtggaaca gctgccctgg gctgtctggt caaggactac 1380
tttcctgagc ctgtgacagt gtcctggaac tctggggctc tgacatctgg ggtgcacaca 1440
ttccctgctg tgctgcagtc ctctggcctg tacagcctgt cctctgtggt cactgtgcct 1500
agctctagcc tgggcaccca gacctacatc tgcaatgtga accacaagcc tagcaacacc 1560
aaggtggaca agaaggctga gcccaagagc tgtgataaga cccacacctg tcctccatgt 1620
cctgctccag agctgcttgg aggaccatca gtgtttctgt tccctccaaa gcctaaggac 1680
accctgatga tcagcagaac ccctgaagtg acctgtgtgg tggtggatgt gtcccatgag 1740
gacccagaag tgaagttcaa ttggtatgtg gatggtgttg aggtgcacaa tgccaagacc 1800
aagcctagag aggaacagta caacagcacc tacagagtgg tgtctgtgct gacagtgctg 1860
caccaggact ggctgaatgg caaagagtac aagtgcaagg tgtccaacaa ggccctgcct 1920
gctcctattg aaaagaccat cagcaaggcc aagggccagc ctagggaacc ccaagtgtat 1980
accctgcctc ctagcagaga tgagctgacc aagaaccagg tgtccctgac atgcctggtt 2040
aagggcttct acccctctga cattgctgtg gaatgggaga gcaatggcca gcctgagaac 2100
aactacaaga ccacacctcc tgtgctggac tctgatggct cattcttcct gtactccaag 2160
ctgactgtgg acaagtccag atggcagcaa ggcaatgtgt tcagctgctc tgtgatgcat 2220
gaggccctgc acaaccacta cacacagaag tctctgtctc tgagccctgg caagagaaag 2280
agaaggagtg gctctggggc caccaacttc agcctgctga aacaggctgg ggatgttgaa 2340
gagaaccctg gacctatgga cttccaggtg cagatcatca gctttctgct tatctctgcc 2400
agtgtgatca tgagcagggg agacatccag atgacacaga gccctctgag cctgccagtg 2460
acacctgggg aacctgccag catctcttgc agaagctctc agagcctcct ggattctgat 2520
gatggcaaca cctacctgga ctggtatctg cagaagcctg gccagtctcc tcagctgctg 2580
atctacaccc tgagctacag agccagtggg gtgccagaca gattctctgg ctctggatct 2640
ggcactgact tcacactgaa gattagcaga gtggaagctg aggatgtggg agtctactac 2700
tgtatgcaga ggattgagtt ccctctgact tttggtggtg gtacaaaggt ggaaatcaag 2760
aggacagtgg ctgctccttc tgtgttcatc ttcccaccat ctgatgagca gctcaagagt 2820
ggcacagcct ctgttgtgtg tctgctgaac aacttctacc ctagggaagc caaggtgcag 2880
tggaaagtgg acaatgccct ccagtctggc aacagccaag agagtgtgac agaacaggac 2940
agcaaggact ccacctacag cctgagcagc accctgacac tgagcaaggc tgactatgag 3000
aagcacaaag tctatgcctg tgaagtgaca caccagggac tgagcagccc tgtgaccaag 3060
agcttcaaca ggggagagtg cagctgaaga tctacttctg gctaataaaa gatcagagct 3120
ctagtgatct gtgtgttggt tttttgtgtc tgcattctag caggagtcaa tgggaaaaac 3180
ccattggagc caagtacact gactcaatag ggactttcca ttgggttttg cccagtacat 3240
aaggtcaata gggggtgagt caacaggaaa gtcccattgg agccaagtac attgagtcaa 3300
tagggacttt ccaatgggtt ttgcccagta cataaggtca atgggaggta agccaatggg 3360
tttttcccat tactgacatg tatactgagt cattagggac tttccaatgg gttttgccca 3420
gtacataagg tcaatagggg tgaatcaaca ggaaagtccc attggagcca agtacactga 3480
gtcaataggg actttccatt gggttttgcc cagtacaaaa ggtcaatagg gggtgagtca 3540
atgggttttt cccattattg gcacatacat aaggtcaata ggggtgacta gtggagaaga 3600
gcatgcttga gggctgagtg cccctcagtg ggcagagagc acatggccca cagtccctga 3660
gaagttgggg ggaggggtgg gcaattgaac tggtgcctag agaaggtggg gcttgggtaa 3720
actgggaaag tgatgtggtg tactggctcc acctttttcc ccagggtggg ggagaaccat 3780
atataagtgc agtagtctct gtgaacattc aagcttctgc cttctccctc ctgtgagttt 3840
ggtaagtcac tgactgtcta tgcctgggaa agggtgggca ggagatgggg cagtgcagga 3900
aaagtggcac tatgaaccct gcagccctag acaattgtac taaccttctt ctctttcctc 3960
tcctgacagg ttggtaacca tgggctggtc cctgatcctg ctgttcctgg tggctgtggc 4020
caccagagtg ctgagccagg tgcagctgca gcagcctggg gctgagcttg tgaaacctgg 4080
ggcctctgtg aagatgagct gcaaggcctc tggctacacc ttcaccagct acaacatgca 4140
ctgggtcaag cagacccctg gcagaggcct ggaatggatt ggagccatct accctggcaa 4200
tggggacacc tcctacaacc agaagttcaa gggcaaggcc accctgacag ctgacaagag 4260
cagcagcaca gcctacatgc agctgtccag cctgacctct gaggactctg ctgtgtacta 4320
ctgtgccagg tccacctact atgggggaga ctggtacttc aatgtgtggg gagctggcac 4380
cacagtgaca gtgtctgctg ccagcaccaa gggcccctct gtgtttcctc tggcccccag 4440
cagcaagagc acctctgggg gaacagctgc cctgggctgc cttgtgaagg actacttccc 4500
tgagcctgtg actgtgtcct ggaactctgg ggccctgaca tctggggtgc acaccttccc 4560
tgcagtgctg cagtccagtg gcctgtactc cctgtcctct gttgtgacag tgcccagctc 4620
cagcctgggc acccagacct acatctgcaa tgtgaaccac aagcccagca acaccaaggt 4680
ggacaagaag gctgagccca agagctgtga caagacccac acctgtcccc cctgtcctgc 4740
ccctgaactg ctgggaggac cttctgtgtt cctgttccca cccaagccca aggataccct 4800
gatgatcagc agaacccctg aagtgacctg tgtggtggtg gatgtgtccc atgaggaccc 4860
agaagtgaag ttcaattggt atgtggatgg ggtggaagtg cacaatgcca agaccaagcc 4920
cagagaggaa cagtacaaca gcacctacag agtggtgtct gtgctgactg tgctgcacca 4980
ggactggctg aatggcaaag agtacaagtg caaggtgtcc aacaaggccc tgccagcccc 5040
cattgagaaa accatcagca aggccaaggg ccagcctaga gaaccccagg tgtacacact 5100
gccccctagc agggatgagc tgaccaagaa ccaggtgtcc ctgacatgcc ttgtgaaagg 5160
cttctacccc tctgacattg ctgtggaatg ggagagcaat ggacagcctg agaacaacta 5220
caagaccacc ccccctgtgc tggactctga tggctcattc ttcctgtaca gcaagctgac 5280
agtggacaag tccagatggc agcagggcaa tgtgttcagc tgctctgtga tgcatgaggc 5340
cctgcacaac cactacaccc agaaaagcct gtccctgtcc cctggcaaga gaaagagaag 5400
gagtggaagt ggagctacta acttcagcct gctgaagcag gctggagatg tggaggagaa 5460
ccctggacct atggacttcc aggtgcagat catcagcttt ctgctgatct ctgcctctgt 5520
gatcatgagc agaggccaga ttgtgctgag ccagagccct gccatcctgt ctgcaagccc 5580
tggggagaaa gtgaccatga cctgcagagc cagcagctct gtgtcctaca tccactggtt 5640
ccagcagaag cctggcagca gccccaagcc ttggatctat gccaccagca acctggcatc 5700
tggggtgcca gtcagattct ctggctctgg atctggcacc agctacagcc tgaccatcag 5760
cagagtggaa gctgaggatg ctgccaccta ctactgccag cagtggacca gcaatccccc 5820
cacctttgga gggggcacca agctggaaat caagagaaca gtggctgccc cctctgtgtt 5880
catcttccca ccctctgatg agcagctgaa gtctggaaca gcctctgttg tgtgcctgct 5940
gaacaacttc taccccagag aagccaaggt gcagtggaag gtggacaatg ccctgcagtc 6000
tggcaactcc caggaatctg tgacagagca ggacagcaag gactccacct actccctgag 6060
cagcaccctg accctgagca aggctgacta tgagaagcac aaagtgtatg cctgtgaagt 6120
gacccaccag ggcctgtcca gccctgtgac caagagcttc aacagagggg agagctgaag 6180
atctacttct ggctaataaa agatcagagc tctagtgatc tgtgtgttgg ttttttgtgt 6240
ctgcattcta gctgttacat aacttatggt aaatggcctg cctggctgac tgcccaatga 6300
cccctgccca atgatgtcaa taatgatgta tgttcccatg taatgccaat agggactttc 6360
cattgatgtc aatgggtgga gtatttatgg taactgccca cttggcagta catcaagtgt 6420
atcatatgcc aagtatgccc cctattgatg tcaatgatgg taaatggcct gcctggcatt 6480
atgcccagta catgacctta tgggactttc ctacttggca gtacatctat gtattagtca 6540
ttgctattac catggattag tggagaagag catgcttgag ggctgagtgc ccctcagtgg 6600
gcagagagca catggcccac agtccctgag aagttggggg gaggggtggg caattgaact 6660
ggtgcctaga gaaggtgggg cttgggtaaa ctgggaaagt gatgtggtgt actggctcca 6720
cctttttccc cagggtgggg gagaaccata tataagtgca gtagtctctg tgaacattca 6780
agcttctgcc ttctccctcc tgtgagtttg gatatcgtaa gtcactgact gtctatgcct 6840
gggaaagggt gggcaggaga tggggcagtg caggaaaagt ggcactatga accctgcagc 6900
cctagacaat tgtactaacc ttcttctctt tcctctcctg acaggttggt aaccaagcca 6960
ccatggtcct ccagacacag gtgttcatca gcctgctgct gtggatcagt ggtgcctatg 7020
gacaggtcca gctgcaagag tctggccctg gacttgtcag acccagccag acactgagcc 7080
tgacctgtac agtctctggc ttcagcctga ccagctactc tgtgcactgg gtcagacagc 7140
ctccaggcag aggactggaa tggctgggag tgatctgggc cagtggtggc acagactaca 7200
actctgccct gatgagcaga ctgagcatcc tgaaggacaa cagcaagaac caggtgtccc 7260
tgagactgtc ctctgtgaca gctgctgata cagctgtgta cttctgtgcc agagatcctc 7320
ctagctctct gctgagactg gactactggg gccagggcac aacagtgaca gtgtccagtg 7380
ccagcacaaa gggcccctct gtgtttcctc tggctcccag cagcaagagc accagtggtg 7440
gaactgctgc cctgggctgt ctggtcaagg actactttcc tgagcctgtg actgtgtcct 7500
ggaactctgg ggctctgaca tctggggtgc acacattccc tgctgtgctg caatcctctg 7560
gcctgtacag cctcagctct gtggtcacag tgcctagctc tagcctgggc acccagacct 7620
acatctgcaa tgtgaaccac aagcctagca acaccaaggt ggacaagaag gctgagccca 7680
agagctgtga caagacccac acctgtcctc catgtcctgc tccagagctg cttggaggac 7740
ccagtgtgtt cctgtttcct ccaaagccaa aggacaccct gatgatcagc agaacccctg 7800
aagtgacctg tgtggtggtg gatgtgtccc atgaggaccc tgaagtcaag ttcaattggt 7860
atgtggatgg tgttgaggtg cacaatgcca agaccaagcc tagagaggaa cagtacaaca 7920
gcacctacag agtggtgtca gtgctgacag tgctgcacca ggactggctg aatggcaaag 7980
agtacaagtg caaggtgtcc aacaaggccc tgcctgctcc tattgaaaag accatcagca 8040
aggccaaggg ccagcctagg gaaccccagg tttacacact gccacctagc agagatgagc 8100
tgaccaaaaa tcaggtttcc ctgacctgcc tggttaaggg cttctacccc tctgacattg 8160
ctgtggaatg ggagagcaat ggccagcctg agaacaacta caagacaacc cctcctgtgc 8220
tggactctga tggctcattc ttcctgtact ccaagctgac tgtggacaaa agcagatggc 8280
agcaaggcaa tgtgttcagc tgctctgtga tgcatgaggc cctgcacaac cactacaccc 8340
agaagtccct gtctctgagc cctggcaaga gaaagagaag gagtggctct ggggccacca 8400
actttagcct gctgaaacag gctggggatg ttgaagagaa ccctggacct atggtgctgc 8460
aaacccaggt tttcatttct ctgctcctct ggattagtgg tgcttatggg gacattgtga 8520
tgacacagag ccctagcagc ctgtctgcct ctgtgggaga cagagtgacc atcacatgca 8580
agtccagcca gagtctgctg aactctggca accagaagaa ctacctggcc tggtatcagc 8640
aaaagcctgg caaggcccct aagctgctca tctatggggc cagcaccaga gagtctgggg 8700
tcccagatag attctctggc tctggatctg gcactgactt caccttcacc atcagctccc 8760
tgcaaccaga ggacattgcc acctactact gccagaatgt gcacagcttc ccattcacct 8820
ttggacaggg cactaaggtg gaaatcaaga ggactgtggc tgctccttct gtgttcatct 8880
tcccaccatc agatgaacag ctgaagagtg gcacagcctc tgttgtgtgc ctgctcaaca 8940
acttctaccc tagagaagcc aaggtgcagt ggaaagtgga caatgccctc cagtctggca 9000
acagccaaga atctgtgact gagcaggact ccaaggacag cacatacagc ctgagcagca 9060
cactgaccct gagcaaggct gactatgaga agcacaaagt ctatgcctgt gaagtgacac 9120
accagggcct gtctagccca gtgaccaagt ccttcaacag gggagagagc tgaagatcta 9180
cttctggcta ataaaagatc agagctctag tgatctgtgt gttggttttt tgtgtctgca 9240
ttctagcagg agtcaatggg aaaaacccat tggagccaag tacactgact caatagggac 9300
tttccattgg gttttgccca gtacataagg tcaatagggg gtgagtcaac aggaaagtcc 9360
cattggagcc aagtacattg agtcaatagg gactttccaa tgggttttgc ccagtacata 9420
aggtcaatgg gaggtaagcc aatgggtttt tcccattact gacatgtata ctgagtcatt 9480
agggactttc caatgggttt tgcccagtac ataaggtcaa taggggtgaa tcaacaggaa 9540
agtcccattg gagccaagta cactgagtca atagggactt tccattgggt tttgcccagt 9600
acaaaaggtc aatagggggt gagtcaatgg gtttttccca ttattggcac atacataagg 9660
tcaatagggg tgactagtgg agaagagcat gcttgagggc tgagtgcccc tcagtgggca 9720
gagagcacat ggcccacagt ccctgagaag ttggggggag gggtgggcaa ttgaactggt 9780
gcctagagaa ggtggggctt gggtaaactg ggaaagtgat gtggtgtact ggctccacct 9840
ttttccccag ggtgggggag aaccatatat aagtgcagta gtctctgtga acattcaagc 9900
ttctgccttc tccctcctgt gagtttggta agtcactgac tgtctatgcc tgggaaaggg 9960
tgggcaggag atggggcagt gcaggaaaag tggcactatg aaccctgcag ccctagacaa 10020
ttgtactaac cttcttctct ttcctctcct gacaggttgg taaccaagcc accatgggat 10080
ggtccctgat cctgctgttt ctggtggctg tggccaccag agtgctgtct gaagtgcagc 10140
tggtggaatc tggccctggc ctggttaagc cctctgacat cctgagcctg acctgtgctg 10200
tgtctggcta cagcatcagc agcaactact actggggctg gatcagacag cctcctggca 10260
aaggcctgga atggattggc agcatctacc actctggctc cacctactac aagcccagcc 10320
tggaaagcag actgggcatc tctgtggaca ccagcaagaa ccagttcagc ctgaagctga 10380
gctttgtgtc tgctgctgac actgctgtgt actactgtgc cagacatgtt aggagtggct 10440
accctgacac agcctactac tttgataagt ggggccaggg caccctggtc acagtgtctg 10500
cttctacaaa gggcccctct gtgttcccac tggctcctag cagcaagagc accagtggtg 10560
gaacagctgc cctgggctgt ctggtcaagg actactttcc tgagccagtg acagtgtcct 10620
ggaactctgg ggctctgact tctggggtgc acacattccc tgctgtgctc cagtcctctg 10680
gcctgtacag cctgtcctct gtggtcactg tgccaagctc tagcctgggc acccagacct 10740
acatctgcaa tgtgaaccac aagcctagca acaccaaggt ggacaagaag gctgagccca 10800
agagctgtga caagacccac acctgtcctc catgtcctgc tccagagctg cttggaggac 10860
cttctgtgtt tctgttccct ccaaagccaa aggacaccct gatgatcagc agaacccctg 10920
aagtgacctg tgtggtggtg gatgtgtccc atgaggaccc agaagtgaag ttcaattggt 10980
atgtggatgg tgttgaggtg cacaatgcca agaccaagcc tagagaggaa cagtacaaca 11040
gcacctacag ggttgtgtca gtgctgactg tgctgcacca ggactggctg aatggcaaag 11100
agtacaagtg caaggtgtcc aacaaggccc tgcctgctcc tattgaaaag accatcagca 11160
aggccaaggg acagcctagg gaaccccagg tgtacacact gccacctagc agagatgagc 11220
tgaccaagaa tcaggtgtcc ctgacatgcc ttgtgaaggg cttctaccct tctgacattg 11280
cagtggaatg ggagagcaat ggccagcctg agaacaacta caagacaacc cctcctgtgc 11340
tggactctga tggctcattc ttcctgtact ccaagctgac agtggacaag tccagatggc 11400
agcaaggcaa tgtgttcagc tgctctgtga tgcatgaggc cctgcacaac cactacacac 11460
agaagtccct gtctctgagc cctggcaaga gaaagagaag gagtggatct ggggccacca 11520
acttcagcct gctgaaacag gctggggatg ttgaagagaa ccctggacct atggcctggg 11580
ctctgctgct tctgggactg ctgtctcact gcacaggcag tgtgaccagc tatgtgctga 11640
cccagcctcc atctgtgtct gtggctccag gggagacagc cagaatcagc tgtggtggca 11700
acaacattgg cacaaaggtg ctgcactggt atcagcagac tccaggacag gcaccagtgc 11760
tggtggtgta tgatgactct gacagaccct ctggcatccc agagaggttc tctggcagca 11820
actctggcaa cacagccaca ctgaccatct ccagagtgga agttggagat gaggctgatt 11880
actactgcca agtgtgggac atcagcacag accaggctgt gtttggtggt ggcaccaagc 11940
tcactgtgct gggccaacct aaagctgccc cttctgtgac actgttccca cctagctctg 12000
aggaactcca ggctaacaag gccacacttg tgtgcctgat cagtgacttc tacccagggg 12060
ctgtgactgt ggcctggaag gctgatagca gccctgtgaa ggctggggtt gagacaacca 12120
cacctagcaa gcagagcaac aacaaatatg ctgccagcag ctacctgagt ctgacccctg 12180
agcagtggaa gtcccacaga tcctacagct gtcaagtgac ccatgagggc tccacagtgg 12240
aaaagacagt ggcccctaca gagtgctcct gaagatctac ttctggctaa taaaagatca 12300
gagctctagt gatctgtgtg ttggtttttt gtgtctgcat tctagctcta gtgatcagca 12360
gttcaacctg ttgatagtat gtactaagct ctcatgttta atgtactaag ctctcatgtt 12420
taatgaacta aaccctcatg gctaatgtac taagctctca tggctaatgt actaagctct 12480
catgtttcat gtactaagct ctcatgtttg aacaataaaa ttaatataaa tcagcaactt 12540
aaatagcctc taaggtttta agttttataa gaaaaaaaag aatatataag gcttttaaag 12600
gttttaaggt ttcctaggtt atcctcatat gagctcttag aaaaactcat ccagcatcaa 12660
atgaaactgc aatttattca tatcaggatt atcaatacca tatttttgaa aaagtctttt 12720
ctgtaatgaa ggagaaaact cacccaggca gttccatagg atggcaagat cctggtatct 12780
gtctgcaatt ccaactcttc caacatcaat acaacctatt aatttcccct catcaaaaat 12840
aaggttatca agtgagaaat caccatgagt gaccactgaa tctggtgaga atggcaaaag 12900
attatgcatt tctttccaga cttgttcaac aggccagcca tttctctcat catcaaaatc 12960
actggcatca accaaaccat tattcattct tgattgggcc tgagccagtc taaatactct 13020
atcagagtta aaaggacaat tacaaacagg aatggaatgc aatcttctca ggaacactgc 13080
cagggcatca acaatatttt cacctgaatc aggatattct tccaatacct ggaatgctgt 13140
tttccctggg atggcagtgg tgagtaacca tgcatcatca ggagttctga taaaatgctt 13200
gatggttgga agaggcataa attcagtcag ccagtttagt ctgaccatct catctgtaac 13260
atcattggca acagaacctt tgccatgttt cagaaacaac tctggggcat ctggcttccc 13320
atacaatcta tagattgtgg cacctgattg cccaacatta tctctagccc atttataccc 13380
atataaatca gcatccatgt tggaatttaa tcttggcctg gagcaagagg tttctctttg 13440
aatatggctc atacatgtgc acctcctata gtgagttgta ttatactatg cagatatact 13500
atgccaatgt ttaattgtca g 13521
<210> 30
<211> 9595
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic
<400> 30
cactatgtgt taattaaaat tatctctaag gcatgtgaac tggctgtctt ggttttcatc 60
tgtacttcat ctgctacctc tgtgacctga aacatattta taattccatt aagctgtgca 120
tatgatagat ttatcatatg tattttcctt aaaggatttt tgtaagaact aattgaattg 180
atacctgtaa agtctttatc acactaccca ataaataata aatctctttg ttcagctctc 240
tgtttctata aatatgtacc agttttattg tttttagtgg tagtgatttt attctctttc 300
tatatatata cacacacatg tgtgcattca taaatatata caatttttat gaataaaaaa 360
ttattagcaa tcaatattga aaaccactga tttttgttta tgtgagcaaa cagcagatta 420
aaaggaattt gaattctcat agctagcagg agtcaatggg aaaaacccat tggagccaag 480
tacactgact caatagggac tttccattgg gttttgccca gtacataagg tcaatagggg 540
gtgagtcaac aggaaagtcc cattggagcc aagtacattg agtcaatagg gactttccaa 600
tgggttttgc ccagtacata aggtcaatgg gaggtaagcc aatgggtttt tcccattact 660
gacatgtata ctgagtcatt agggactttc caatgggttt tgcccagtac ataaggtcaa 720
taggggtgaa tcaacaggaa agtcccattg gagccaagta cactgagtca atagggactt 780
tccattgggt tttgcccagt acaaaaggtc aatagggggt gagtcaatgg gtttttccca 840
ttattggcac atacataagg tcaatagggg tgactagtgg agaagagcat gcttgagggc 900
tgagtgcccc tcagtgggca gagagcacat ggcccacagt ccctgagaag ttggggggag 960
gggtgggcaa ttgaactggt gcctagagaa ggtggggctt gggtaaactg ggaaagtgat 1020
gtggtgtact ggctccacct ttttccccag ggtgggggag aaccatatat aagtgcagta 1080
gtctctgtga acattcaagc ttctgccttc tccctcctgt gagtttggta agtcactgac 1140
tgtctatgcc tgggaaaggg tgggcaggag atggggcagt gcaggaaaag tggcactatg 1200
aaccctgcag ccctagacaa ttgtactaac cttcttctct ttcctctcct gacaggttgg 1260
taaccaagcc accatgggat ggtccctgat cctgctgttt ctggtggctg tggccaccag 1320
agtgctgtct gaagtgcagc tggtggaaag tggtggtggc ctggttcagc ctggtggctc 1380
tctgagactg agctgtgctg cctctggctt cattgtgtcc agcaactaca tgagctgggt 1440
cagacaggcc cctggcaaag gactggaatg ggtgtcagtg atctacagtg gtggcagcac 1500
ctactatgct gactctgtga agggcagatt caccatcagc agacacaaca gcaagaacac 1560
cctgtacctg cagatgaaca gcctgagagc tgaggacact gctgtgtact actgtgccag 1620
agaagcctat ggcatggatg tgtggggcca gggcacaaca gtgactgtgt cctctgccag 1680
cacaaagggc ccctctgtgt ttcctctggc tcccagcagc aagagcacca gtggtggaac 1740
agctgccctg ggctgtctgg tcaaggacta ctttcctgag cctgtgacag tgtcctggaa 1800
ctctggggct ctgacatctg gggtgcacac attccctgca gtgctgcagt cctctggcct 1860
gtacagcctg tcctctgtgg tcacagtgcc tagctctagc ctgggcaccc agacctacat 1920
ctgcaatgtg aaccacaagc ctagcaacac caaggtggac aagaaggctg agcccaagag 1980
ctgtgacaag acccacacct gtcctccatg tcctgctcca gagctgcttg gaggaccatc 2040
agtgtttctg ttccctccaa agcctaagga caccctgatg atcagcagaa cccctgaagt 2100
gacctgtgtg gtggttgatg tgtcccatga ggacccagaa gtgaagttca attggtatgt 2160
ggatggtgtt gaggtgcaca atgccaagac caagcctaga gaggaacagt acaactccac 2220
ctacagagtg gtttctgtgc tgacagtgct ccaccaggac tggctgaatg gcaaagagta 2280
caagtgcaag gtgtccaaca aggccctgcc tgctcctatt gaaaagacca tctccaaggc 2340
caagggccag cctagggaac cccaggttta cacactgcca cctagcaggg atgagctgac 2400
caagaaccag gtgtccctga catgcctggt taagggcttc tacccctctg acattgctgt 2460
ggaatgggag agcaatggcc agccagagaa caactacaag acaacccctc ctgtgctgga 2520
ctctgatggc tcattcttcc tgtactccaa gctgactgtg gacaagtcca gatggcagca 2580
gggcaatgtc tttagctgct ctgtgatgca tgaggccctg cacaaccact acacacagaa 2640
gtccctgtct ctgagccctg gcaagagaaa gagaaggagt ggctctgggg ccaccaactt 2700
cagcctgctg aaacaggctg gggatgttga agagaaccct ggacctatgg cctgggctct 2760
gctgcttctg ggactgctgt ctcactgcac tggctctgtg acagacattg tgatgaccca 2820
gtctccatcc ttcctgagtg cctctgtggg agacagagtg accatcacct gtagagccag 2880
ccagggcatc agctcttacc tggcttggta tcagcaaaag cctggcaagg cccctaagct 2940
gctgatctat gctgcctcca cactgcagtc aggggtgccc tccagatttt ctggctctgg 3000
atctggcact gagttcaccc tgaccatcag ctccctgcag cctgaggact ttgccaccta 3060
ctactgccag cagctgaaca gctaccctcc ttacaccttt ggacagggca ccaagctgga 3120
aatcaaggga acaaagctga cagtcctggg ccagccaaag gctgctcctt ctgtgacact 3180
gttcccacct agctctgagg aactgcaggc taacaaggct acccttgtgt gcctgatctc 3240
tgacttctac ccaggggctg tgactgtggc ttggaaggct gatagcagcc ctgtgaaggc 3300
tggggttgag acaaccacac ctagcaagca gagcaacaac aaatatgctg ccagctccta 3360
cctgagtctg acccctgagc agtggaagtc ccacagatcc tacagctgcc aagtgaccca 3420
tgagggctcc acagtggaaa agacagtggc cccaacagag tgctcctgaa gatctacttc 3480
tggctaataa aagatcagag ctctagtgat ctgtgtgttg gttttttgtg tctgcattct 3540
agcagagccc cactgtgttc atcttacaga tggaaatact gacattcaga ggagttagtt 3600
aacttgccta ggtgattcag ctaataagtg caagaaagat ttcaatccaa ggtgatttga 3660
ttctgaagcc tgtgctaatc acattacacc aagctacaac ttcatttata aataataagt 3720
cagctttcaa gggcctttca ggtgtcctgc acttctacaa gctgtgccat ttagtgaaca 3780
caaaatgagc cttctgatga agtagtcttt tcattatttc agatattaga acactaaaat 3840
tcttagctgc cagctgattg aaggctggga caaaattcaa acatgcatct acaacaatat 3900
atatctcaat gttagtctcc aaattctatt gacttcaact caagagaata taaagagcta 3960
gtctttatac actctttaag gtatgatatc atctggaaag taacaaaatt gatgcaaatt 4020
tgaatgaact ttatcatggt gtatttacac aatgtgtttc ttctccctgc aatgtatttc 4080
tttctctaat tccttccatt tgatctttca tacacaatct ggttctgatg tatgtttttt 4140
ggatgcactt ttcaactcca aaagacagag ctagttactt tcttcctggt gctccaagca 4200
ctgtatttgt atctgtattc aagccctttg caatattgta ctggatcatt atttcacctc 4260
taggatggct tccccaggca acttgtgttc acccagagac tacattttgt atcttgttga 4320
cctttgaact tccaccagtg tctaaaaata atatgtatgc aaaattactt gctatgagaa 4380
tgtataatta aacaatataa aaaggagaag caaggagaga aacacaggtg tgtatttgtg 4440
tttgtgtgct taaaaggcag tgtggaaaag gaagaaatgc catttatagt gaggagacaa 4500
agttatatta cctcttatct ggcttttaag gagattttgc tgagctaaaa atcctatatt 4560
catagaaaag ccttacctga gttgccaata cctcaattca gtctagctgt tacataactt 4620
atggtaaatg gcctgcctgg ctgactgccc aatgacccct gcccaatgat gtcaataatg 4680
atgtatgttc ccatgtaatg ccaataggga ctttccattg atgtcaatgg gtggagtatt 4740
tatggtaact gcccacttgg cagtacatca agtgtatcat atgccaagta tgccccctat 4800
tgatgtcaat gatggtaaat ggcctgcctg gcattatgcc cagtacatga ccttatggga 4860
ctttcctact tggcagtaca tctatgtatt agtcattgct attaccatgg attagtggag 4920
aagagcatgc ttgagggctg agtgcccctc agtgggcaga gagcacatgg cccacagtcc 4980
ctgagaagtt ggggggaggg gtgggcaatt gaactggtgc ctagagaagg tggggcttgg 5040
gtaaactggg aaagtgatgt ggtgtactgg ctccaccttt ttccccaggg tgggggagaa 5100
ccatatataa gtgcagtagt ctctgtgaac attcaagctt ctgccttctc cctcctgtga 5160
gtttggatgc acctactaga tatcttggta agtcactgac tgtctatgcc tgggaaaggg 5220
tgggcaggag gtggggcagt gcaggaaaag tggcactgtg aaccctgcag ccctagacaa 5280
ttgtactaac cttcttctct ttcctctcct gacaggttgg taaccaagcc accatgggct 5340
ggtccctgat cctgctgttc ctggtggctg tggccaccag agtgctgagc caggtgcagc 5400
tgcagcagcc tggggctgag cttgtgaaac ctggggcctc tgtgaagatg agctgcaagg 5460
cctctggcta caccttcacc agctacaaca tgcactgggt caagcagacc cctggcagag 5520
gcctggaatg gattggagcc atctaccctg gcaatgggga cacctcctac aaccagaagt 5580
tcaagggcaa ggccaccctg acagctgaca agagcagcag cacagcctac atgcagctgt 5640
ccagcctgac ctctgaggac tctgctgtgt actactgtgc caggtccacc tactatgggg 5700
gagactggta cttcaatgtg tggggagctg gcaccacagt gacagtgtct gctgccagca 5760
ccaagggccc ctctgtgttt cctctggccc ccagcagcaa gagcacctct gggggaacag 5820
ctgccctggg ctgccttgtg aaggactact tccctgagcc tgtgactgtg tcctggaact 5880
ctggggccct gacatctggg gtgcacacct tccctgcagt gctgcagtcc agtggcctgt 5940
actccctgtc ctctgttgtg acagtgccca gctccagcct gggcacccag acctacatct 6000
gcaatgtgaa ccacaagccc agcaacacca aggtggacaa gaaggctgag cccaagagct 6060
gtgacaagac ccacacctgt cccccctgtc ctgcccctga actgctggga ggaccttctg 6120
tgttcctgtt cccacccaag cccaaggata ccctgatgat cagcagaacc cctgaagtga 6180
cctgtgtggt ggtggatgtg tcccatgagg acccagaagt gaagttcaat tggtatgtgg 6240
atggggtgga agtgcacaat gccaagacca agcccagaga ggaacagtac aacagcacct 6300
acagagtggt gtctgtgctg actgtgctgc accaggactg gctgaatggc aaagagtaca 6360
agtgcaaggt gtccaacaag gccctgccag cccccattga gaaaaccatc agcaaggcca 6420
agggccagcc tagagaaccc caggtgtaca cactgccccc tagcagggat gagctgacca 6480
agaaccaggt gtccctgaca tgccttgtga aaggcttcta cccctctgac attgctgtgg 6540
aatgggagag caatggacag cctgagaaca actacaagac caccccccct gtgctggact 6600
ctgatggctc attcttcctg tacagcaagc tgacagtgga caagtccaga tggcagcagg 6660
gcaatgtgtt cagctgctct gtgatgcatg aggccctgca caaccactac acccagaaaa 6720
gcctgtccct gtcccctggc aagagaaaga gaaggagtgg aagtggagct actaacttca 6780
gcctgctgaa gcaggctgga gatgtggagg agaaccctgg acctatggac ttccaggtgc 6840
agatcatcag ctttctgctg atctctgcct ctgtgatcat gagcagaggc cagattgtgc 6900
tgagccagag ccctgccatc ctgtctgcaa gccctgggga gaaagtgacc atgacctgca 6960
gagccagcag ctctgtgtcc tacatccact ggttccagca gaagcctggc agcagcccca 7020
agccttggat ctatgccacc agcaacctgg catctggggt gccagtcaga ttctctggct 7080
ctggatctgg caccagctac agcctgacca tcagcagagt ggaagctgag gatgctgcca 7140
cctactactg ccagcagtgg accagcaatc cccccacctt tggagggggc accaagctgg 7200
aaatcaagag aacagtggct gccccctctg tgttcatctt cccaccctct gatgagcagc 7260
tgaagtctgg aacagcctct gttgtgtgcc tgctgaacaa cttctacccc agagaagcca 7320
aggtgcagtg gaaggtggac aatgccctgc agtctggcaa ctcccaggaa tctgtgacag 7380
agcaggacag caaggactcc acctactccc tgagcagcac cctgaccctg agcaaggctg 7440
actatgagaa gcacaaagtg tatgcctgtg aagtgaccca ccagggcctg tccagccctg 7500
tgaccaagtc cttcaacagg ggagagtgtt gaagatctac ttctggctaa taaaagatca 7560
gagctctagt gatctgtgtg ttggtttttt gtgtctgcat tctagcagtc aatatgttca 7620
ccccaaaaaa gctgtttgtt aacttgtcaa cctcattcta aaatgtatat agaagcccaa 7680
aagacaataa caaaaatatt cttgtagaac aaaatgggaa agaatgttcc actaaatatc 7740
aagatttaga gcaaagcatg agatgtgtgg ggatagacag tgaggctgat aaaatagagt 7800
agagctcaga aacagaccca ttgatatatg taagtgacct atgaaaaaaa tatggcattt 7860
tacaatggga aaatgatggt ctttttcttt tttagaaaaa cagggaaata tatttatatg 7920
taaaaaataa aagggaaccc atatgtcata ccatacacac aaaaaaattc cagtgaatta 7980
taagtctaaa tggagaaggc aaaactttaa atcttttaga aaataatata gaagcatgcc 8040
atcaagactt cagtgtagag aaaaatttct tatgactcaa agtcctaacc acaaagaaaa 8100
gattgttaat tagattgcat gaatattaag acttattttt aaaattaaaa aaccattaag 8160
aaaagtcagg ccatagaatg acagaaaata tttgcaacac cccagtaaag agaattgtaa 8220
tatgcagatt ataaaaagaa gtcttacaaa tcagtaaaaa ataaaactag acaaaaattt 8280
gaacagatga aagagaaact ctaaataatc attacacatg agaaactcaa tctcagaaat 8340
cagagaacta tcattgcata tacactaaat tagagaaata ttaaaaggct aagtaacatc 8400
tgtggcttaa ttaatctagc tctagtgatc agcagttcaa cctgttgata gtatgtacta 8460
agctctcatg tttaatgtac taagctctca tgtttaatga actaaaccct catggctaat 8520
gtactaagct ctcatggcta atgtactaag ctctcatgtt tcatgtacta agctctcatg 8580
tttgaacaat aaaattaata taaatcagca acttaaatag cctctaaggt tttaagtttt 8640
ataagaaaaa aaagaatata taaggctttt aaaggtttta aggtttccta ggttatcctc 8700
atatgagctc ttagaaaaac tcatccagca tcaaatgaaa ctgcaattta ttcatatcag 8760
gattatcaat accatatttt tgaaaaagtc ttttctgtaa tgaaggagaa aactcaccca 8820
ggcagttcca taggatggca agatcctggt atctgtctgc aattccaact cttccaacat 8880
caatacaacc tattaatttc ccctcatcaa aaataaggtt atcaagtgag aaatcaccat 8940
gagtgaccac tgaatctggt gagaatggca aaagattatg catttctttc cagacttgtt 9000
caacaggcca gccatttctc tcatcatcaa aatcactggc atcaaccaaa ccattattca 9060
ttcttgattg ggcctgagcc agtctaaata ctctatcaga gttaaaagga caattacaaa 9120
caggaatgga atgcaatctt ctcaggaaca ctgccagggc atcaacaata ttttcacctg 9180
aatcaggata ttcttccaat acctggaatg ctgttttccc tgggatggca gtggtgagta 9240
accatgcatc atcaggagtt ctgataaaat gcttgatggt tggaagaggc ataaattcag 9300
tcagccagtt tagtctgacc atctcatctg taacatcatt ggcaacagaa cctttgccat 9360
gtttcagaaa caactctggg gcatctggct tcccatacaa tctatagatt gtggcacctg 9420
attgcccaac attatctcta gcccatttat acccatataa atcagcatcc atgttggaat 9480
ttaatcttgg cctggagcaa gaggtttctc tttgaatatg gctcatacat gtgcacctcc 9540
tatagtgagt tgtattatac tatgcagata tactatgcca atgtttaatt gtcag 9595
<210> 31
<211> 10391
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic
<400> 31
cactatgtga attggaattc tcatagctag caggagtcaa tgggaaaaac ccattggagc 60
caagtacact gactcaatag ggactttcca ttgggttttg cccagtacat aaggtcaata 120
gggggtgagt caacaggaaa gtcccattgg agccaagtac attgagtcaa tagggacttt 180
ccaatgggtt ttgcccagta cataaggtca atgggaggta agccaatggg tttttcccat 240
tactgacatg tatactgagt cattagggac tttccaatgg gttttgccca gtacataagg 300
tcaatagggg tgaatcaaca ggaaagtccc attggagcca agtacactga gtcaataggg 360
actttccatt gggttttgcc cagtacaaaa ggtcaatagg gggtgagtca atgggttttt 420
cccattattg gcacatacat aaggtcaata ggggtgacta gtggagaaga gcatgcttga 480
gggctgagtg cccctcagtg ggcagagagc acatggccca cagtccctga gaagttgggg 540
ggaggggtgg gcaattgaac tggtgcctag agaaggtggg gcttgggtaa actgggaaag 600
tgatgtggtg tactggctcc acctttttcc ccagggtggg ggagaaccat atataagtgc 660
agtagtctct gtgaacattc aagcttctgc cttctccctc ctgtgagttt ggtaagtcac 720
tgactgtcta tgcctgggaa agggtgggca ggagatgggg cagtgcagga aaagtggcac 780
tatgaaccct gcagccctag acaattgtac taaccttctt ctctttcctc tcctgacagg 840
ttggtaacca tgggctggtc cctgatcctg ctgttcctgg tggctgtggc caccagagtg 900
ctgagccagg tgcagctgca gcagcctggg gctgagcttg tgaaacctgg ggcctctgtg 960
aagatgagct gcaaggcctc tggctacacc ttcaccagct acaacatgca ctgggtcaag 1020
cagacccctg gcagaggcct ggaatggatt ggagccatct accctggcaa tggggacacc 1080
tcctacaacc agaagttcaa gggcaaggcc accctgacag ctgacaagag cagcagcaca 1140
gcctacatgc agctgtccag cctgacctct gaggactctg ctgtgtacta ctgtgccagg 1200
tccacctact atgggggaga ctggtacttc aatgtgtggg gagctggcac cacagtgaca 1260
gtgtctgctg ccagcaccaa gggcccctct gtgtttcctc tggcccccag cagcaagagc 1320
acctctgggg gaacagctgc cctgggctgc cttgtgaagg actacttccc tgagcctgtg 1380
actgtgtcct ggaactctgg ggccctgaca tctggggtgc acaccttccc tgcagtgctg 1440
cagtccagtg gcctgtactc cctgtcctct gttgtgacag tgcccagctc cagcctgggc 1500
acccagacct acatctgcaa tgtgaaccac aagcccagca acaccaaggt ggacaagaag 1560
gctgagccca agagctgtga caagacccac acctgtcccc cctgtcctgc ccctgaactg 1620
ctgggaggac cttctgtgtt cctgttccca cccaagccca aggataccct gatgatcagc 1680
agaacccctg aagtgacctg tgtggtggtg gatgtgtccc atgaggaccc agaagtgaag 1740
ttcaattggt atgtggatgg ggtggaagtg cacaatgcca agaccaagcc cagagaggaa 1800
cagtacaaca gcacctacag agtggtgtct gtgctgactg tgctgcacca ggactggctg 1860
aatggcaaag agtacaagtg caaggtgtcc aacaaggccc tgccagcccc cattgagaaa 1920
accatcagca aggccaaggg ccagcctaga gaaccccagg tgtacacact gccccctagc 1980
agggatgagc tgaccaagaa ccaggtgtcc ctgacatgcc ttgtgaaagg cttctacccc 2040
tctgacattg ctgtggaatg ggagagcaat ggacagcctg agaacaacta caagaccacc 2100
ccccctgtgc tggactctga tggctcattc ttcctgtaca gcaagctgac agtggacaag 2160
tccagatggc agcagggcaa tgtgttcagc tgctctgtga tgcatgaggc cctgcacaac 2220
cactacaccc agaaaagcct gtccctgtcc cctggcaaga gaaagagaag gagtggaagt 2280
ggagctacta acttcagcct gctgaagcag gctggagatg tggaggagaa ccctggacct 2340
atggacttcc aggtgcagat catcagcttt ctgctgatct ctgcctctgt gatcatgagc 2400
agaggccaga ttgtgctgag ccagagccct gccatcctgt ctgcaagccc tggggagaaa 2460
gtgaccatga cctgcagagc cagcagctct gtgtcctaca tccactggtt ccagcagaag 2520
cctggcagca gccccaagcc ttggatctat gccaccagca acctggcatc tggggtgcca 2580
gtcagattct ctggctctgg atctggcacc agctacagcc tgaccatcag cagagtggaa 2640
gctgaggatg ctgccaccta ctactgccag cagtggacca gcaatccccc cacctttgga 2700
gggggcacca agctggaaat caagagaaca gtggctgccc cctctgtgtt catcttccca 2760
ccctctgatg agcagctgaa gtctggaaca gcctctgttg tgtgcctgct gaacaacttc 2820
taccccagag aagccaaggt gcagtggaag gtggacaatg ccctgcagtc tggcaactcc 2880
caggaatctg tgacagagca ggacagcaag gactccacct actccctgag cagcaccctg 2940
accctgagca aggctgacta tgagaagcac aaagtgtatg cctgtgaagt gacccaccag 3000
ggcctgtcca gccctgtgac caagagcttc aacagagggg agagctgaag atctacttct 3060
ggctaataaa agatcagagc tctagtgatc tgtgtgttgg ttttttgtgt ctgcattcta 3120
gctgttacat aacttatggt aaatggcctg cctggctgac tgcccaatga cccctgccca 3180
atgatgtcaa taatgatgta tgttcccatg taatgccaat agggactttc cattgatgtc 3240
aatgggtgga gtatttatgg taactgccca cttggcagta catcaagtgt atcatatgcc 3300
aagtatgccc cctattgatg tcaatgatgg taaatggcct gcctggcatt atgcccagta 3360
catgacctta tgggactttc ctacttggca gtacatctat gtattagtca ttgctattac 3420
catggattag tggagaagag catgcttgag ggctgagtgc ccctcagtgg gcagagagca 3480
catggcccac agtccctgag aagttggggg gaggggtggg caattgaact ggtgcctaga 3540
gaaggtgggg cttgggtaaa ctgggaaagt gatgtggtgt actggctcca cctttttccc 3600
cagggtgggg gagaaccata tataagtgca gtagtctctg tgaacattca agcttctgcc 3660
ttctccctcc tgtgagtttg gatatcgtaa gtcactgact gtctatgcct gggaaagggt 3720
gggcaggaga tggggcagtg caggaaaagt ggcactatga accctgcagc cctagacaat 3780
tgtactaacc ttcttctctt tcctctcctg acaggttggt aaccaagcca ccatggtcct 3840
ccagacacag gtgttcatca gcctgctgct gtggatcagt ggtgcctatg gacaggtcca 3900
gctgcaagag tctggccctg gacttgtcag acccagccag acactgagcc tgacctgtac 3960
agtctctggc ttcagcctga ccagctactc tgtgcactgg gtcagacagc ctccaggcag 4020
aggactggaa tggctgggag tgatctgggc cagtggtggc acagactaca actctgccct 4080
gatgagcaga ctgagcatcc tgaaggacaa cagcaagaac caggtgtccc tgagactgtc 4140
ctctgtgaca gctgctgata cagctgtgta cttctgtgcc agagatcctc ctagctctct 4200
gctgagactg gactactggg gccagggcac aacagtgaca gtgtccagtg ccagcacaaa 4260
gggcccctct gtgtttcctc tggctcccag cagcaagagc accagtggtg gaactgctgc 4320
cctgggctgt ctggtcaagg actactttcc tgagcctgtg actgtgtcct ggaactctgg 4380
ggctctgaca tctggggtgc acacattccc tgctgtgctg caatcctctg gcctgtacag 4440
cctcagctct gtggtcacag tgcctagctc tagcctgggc acccagacct acatctgcaa 4500
tgtgaaccac aagcctagca acaccaaggt ggacaagaag gctgagccca agagctgtga 4560
caagacccac acctgtcctc catgtcctgc tccagagctg cttggaggac ccagtgtgtt 4620
cctgtttcct ccaaagccaa aggacaccct gatgatcagc agaacccctg aagtgacctg 4680
tgtggtggtg gatgtgtccc atgaggaccc tgaagtcaag ttcaattggt atgtggatgg 4740
tgttgaggtg cacaatgcca agaccaagcc tagagaggaa cagtacaaca gcacctacag 4800
agtggtgtca gtgctgacag tgctgcacca ggactggctg aatggcaaag agtacaagtg 4860
caaggtgtcc aacaaggccc tgcctgctcc tattgaaaag accatcagca aggccaaggg 4920
ccagcctagg gaaccccagg tttacacact gccacctagc agagatgagc tgaccaaaaa 4980
tcaggtttcc ctgacctgcc tggttaaggg cttctacccc tctgacattg ctgtggaatg 5040
ggagagcaat ggccagcctg agaacaacta caagacaacc cctcctgtgc tggactctga 5100
tggctcattc ttcctgtact ccaagctgac tgtggacaaa agcagatggc agcaaggcaa 5160
tgtgttcagc tgctctgtga tgcatgaggc cctgcacaac cactacaccc agaagtccct 5220
gtctctgagc cctggcaaga gaaagagaag gagtggctct ggggccacca actttagcct 5280
gctgaaacag gctggggatg ttgaagagaa ccctggacct atggtgctgc aaacccaggt 5340
tttcatttct ctgctcctct ggattagtgg tgcttatggg gacattgtga tgacacagag 5400
ccctagcagc ctgtctgcct ctgtgggaga cagagtgacc atcacatgca agtccagcca 5460
gagtctgctg aactctggca accagaagaa ctacctggcc tggtatcagc aaaagcctgg 5520
caaggcccct aagctgctca tctatggggc cagcaccaga gagtctgggg tcccagatag 5580
attctctggc tctggatctg gcactgactt caccttcacc atcagctccc tgcaaccaga 5640
ggacattgcc acctactact gccagaatgt gcacagcttc ccattcacct ttggacaggg 5700
cactaaggtg gaaatcaaga ggactgtggc tgctccttct gtgttcatct tcccaccatc 5760
agatgaacag ctgaagagtg gcacagcctc tgttgtgtgc ctgctcaaca acttctaccc 5820
tagagaagcc aaggtgcagt ggaaagtgga caatgccctc cagtctggca acagccaaga 5880
atctgtgact gagcaggact ccaaggacag cacatacagc ctgagcagca cactgaccct 5940
gagcaaggct gactatgaga agcacaaagt ctatgcctgt gaagtgacac accagggcct 6000
gtctagccca gtgaccaagt ccttcaacag gggagagagc tgaagatcta cttctggcta 6060
ataaaagatc agagctctag tgatctgtgt gttggttttt tgtgtctgca ttctagcagg 6120
agtcaatggg aaaaacccat tggagccaag tacactgact caatagggac tttccattgg 6180
gttttgccca gtacataagg tcaatagggg gtgagtcaac aggaaagtcc cattggagcc 6240
aagtacattg agtcaatagg gactttccaa tgggttttgc ccagtacata aggtcaatgg 6300
gaggtaagcc aatgggtttt tcccattact gacatgtata ctgagtcatt agggactttc 6360
caatgggttt tgcccagtac ataaggtcaa taggggtgaa tcaacaggaa agtcccattg 6420
gagccaagta cactgagtca atagggactt tccattgggt tttgcccagt acaaaaggtc 6480
aatagggggt gagtcaatgg gtttttccca ttattggcac atacataagg tcaatagggg 6540
tgactagtgg agaagagcat gcttgagggc tgagtgcccc tcagtgggca gagagcacat 6600
ggcccacagt ccctgagaag ttggggggag gggtgggcaa ttgaactggt gcctagagaa 6660
ggtggggctt gggtaaactg ggaaagtgat gtggtgtact ggctccacct ttttccccag 6720
ggtgggggag aaccatatat aagtgcagta gtctctgtga acattcaagc ttctgccttc 6780
tccctcctgt gagtttggta agtcactgac tgtctatgcc tgggaaaggg tgggcaggag 6840
atggggcagt gcaggaaaag tggcactatg aaccctgcag ccctagacaa ttgtactaac 6900
cttcttctct ttcctctcct gacaggttgg taaccaagcc accatgggat ggtccctgat 6960
cctgctgttt ctggtggctg tggccaccag agtgctgtct gaagtgcagc tggtggaatc 7020
tggccctggc ctggttaagc cctctgacat cctgagcctg acctgtgctg tgtctggcta 7080
cagcatcagc agcaactact actggggctg gatcagacag cctcctggca aaggcctgga 7140
atggattggc agcatctacc actctggctc cacctactac aagcccagcc tggaaagcag 7200
actgggcatc tctgtggaca ccagcaagaa ccagttcagc ctgaagctga gctttgtgtc 7260
tgctgctgac actgctgtgt actactgtgc cagacatgtt aggagtggct accctgacac 7320
agcctactac tttgataagt ggggccaggg caccctggtc acagtgtctg cttctacaaa 7380
gggcccctct gtgttcccac tggctcctag cagcaagagc accagtggtg gaacagctgc 7440
cctgggctgt ctggtcaagg actactttcc tgagccagtg acagtgtcct ggaactctgg 7500
ggctctgact tctggggtgc acacattccc tgctgtgctc cagtcctctg gcctgtacag 7560
cctgtcctct gtggtcactg tgccaagctc tagcctgggc acccagacct acatctgcaa 7620
tgtgaaccac aagcctagca acaccaaggt ggacaagaag gctgagccca agagctgtga 7680
caagacccac acctgtcctc catgtcctgc tccagagctg cttggaggac cttctgtgtt 7740
tctgttccct ccaaagccaa aggacaccct gatgatcagc agaacccctg aagtgacctg 7800
tgtggtggtg gatgtgtccc atgaggaccc agaagtgaag ttcaattggt atgtggatgg 7860
tgttgaggtg cacaatgcca agaccaagcc tagagaggaa cagtacaaca gcacctacag 7920
ggttgtgtca gtgctgactg tgctgcacca ggactggctg aatggcaaag agtacaagtg 7980
caaggtgtcc aacaaggccc tgcctgctcc tattgaaaag accatcagca aggccaaggg 8040
acagcctagg gaaccccagg tgtacacact gccacctagc agagatgagc tgaccaagaa 8100
tcaggtgtcc ctgacatgcc ttgtgaaggg cttctaccct tctgacattg cagtggaatg 8160
ggagagcaat ggccagcctg agaacaacta caagacaacc cctcctgtgc tggactctga 8220
tggctcattc ttcctgtact ccaagctgac agtggacaag tccagatggc agcaaggcaa 8280
tgtgttcagc tgctctgtga tgcatgaggc cctgcacaac cactacacac agaagtccct 8340
gtctctgagc cctggcaaga gaaagagaag gagtggatct ggggccacca acttcagcct 8400
gctgaaacag gctggggatg ttgaagagaa ccctggacct atggcctggg ctctgctgct 8460
tctgggactg ctgtctcact gcacaggcag tgtgaccagc tatgtgctga cccagcctcc 8520
atctgtgtct gtggctccag gggagacagc cagaatcagc tgtggtggca acaacattgg 8580
cacaaaggtg ctgcactggt atcagcagac tccaggacag gcaccagtgc tggtggtgta 8640
tgatgactct gacagaccct ctggcatccc agagaggttc tctggcagca actctggcaa 8700
cacagccaca ctgaccatct ccagagtgga agttggagat gaggctgatt actactgcca 8760
agtgtgggac atcagcacag accaggctgt gtttggtggt ggcaccaagc tcactgtgct 8820
gggccaacct aaagctgccc cttctgtgac actgttccca cctagctctg aggaactcca 8880
ggctaacaag gccacacttg tgtgcctgat cagtgacttc tacccagggg ctgtgactgt 8940
ggcctggaag gctgatagca gccctgtgaa ggctggggtt gagacaacca cacctagcaa 9000
gcagagcaac aacaaatatg ctgccagcag ctacctgagt ctgacccctg agcagtggaa 9060
gtcccacaga tcctacagct gtcaagtgac ccatgagggc tccacagtgg aaaagacagt 9120
ggcccctaca gagtgctcct gaagatctac ttctggctaa taaaagatca gagctctagt 9180
gatctgtgtg ttggtttttt gtgtctgcat tctagctcta gtgatcagca gttcaacctg 9240
ttgatagtat gtactaagct ctcatgttta atgtactaag ctctcatgtt taatgaacta 9300
aaccctcatg gctaatgtac taagctctca tggctaatgt actaagctct catgtttcat 9360
gtactaagct ctcatgtttg aacaataaaa ttaatataaa tcagcaactt aaatagcctc 9420
taaggtttta agttttataa gaaaaaaaag aatatataag gcttttaaag gttttaaggt 9480
ttcctaggtt atcctcatat gagctcttag aaaaactcat ccagcatcaa atgaaactgc 9540
aatttattca tatcaggatt atcaatacca tatttttgaa aaagtctttt ctgtaatgaa 9600
ggagaaaact cacccaggca gttccatagg atggcaagat cctggtatct gtctgcaatt 9660
ccaactcttc caacatcaat acaacctatt aatttcccct catcaaaaat aaggttatca 9720
agtgagaaat caccatgagt gaccactgaa tctggtgaga atggcaaaag attatgcatt 9780
tctttccaga cttgttcaac aggccagcca tttctctcat catcaaaatc actggcatca 9840
accaaaccat tattcattct tgattgggcc tgagccagtc taaatactct atcagagtta 9900
aaaggacaat tacaaacagg aatggaatgc aatcttctca ggaacactgc cagggcatca 9960
acaatatttt cacctgaatc aggatattct tccaatacct ggaatgctgt tttccctggg 10020
atggcagtgg tgagtaacca tgcatcatca ggagttctga taaaatgctt gatggttgga 10080
agaggcataa attcagtcag ccagtttagt ctgaccatct catctgtaac atcattggca 10140
acagaacctt tgccatgttt cagaaacaac tctggggcat ctggcttccc atacaatcta 10200
tagattgtgg cacctgattg cccaacatta tctctagccc atttataccc atataaatca 10260
gcatccatgt tggaatttaa tcttggcctg gagcaagagg tttctctttg aatatggctc 10320
atacatgtgc acctcctata gtgagttgta ttatactatg cagatatact atgccaatgt 10380
ttaattgtca g 10391
<210> 32
<211> 4146
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic
<400> 32
cactatgtgg acatgaattc aattggctag caggagtcaa tgggaaaaac ccattggagc 60
caagtacact gactcaatag ggactttcca ttgggttttg cccagtacat aaggtcaata 120
gggggtgagt caacaggaaa gtcccattgg agccaagtac attgagtcaa tagggacttt 180
ccaatgggtt ttgcccagta cataaggtca atgggaggta agccaatggg tttttcccat 240
tactgacatg tatactgagt cattagggac tttccaatgg gttttgccca gtacataagg 300
tcaatagggg tgaatcaaca ggaaagtccc attggagcca agtacactga gtcaataggg 360
actttccatt gggttttgcc cagtacaaaa ggtcaatagg gggtgagtca atgggttttt 420
cccattattg gcacatacat aaggtcaata ggggtgacta gtggagaaga gcatgcttga 480
gggctgagtg cccctcagtg ggcagagagc acatggccca cagtccctga gaagttgggg 540
ggaggggtgg gcaattgaac tggtgcctag agaaggtggg gcttgggtaa actgggaaag 600
tgatgtggtg tactggctcc acctttttcc ccagggtggg ggagaaccat atataagtgc 660
agtagtctct gtgaacattc aagcttctgc cttctccctc ctgtgagttt ggtaagtcac 720
tgactgtcta tgcctgggaa agggtgggca ggagatgggg cagtgcagga aaagtggcac 780
tatgaaccct gcagccctag acaattgtac taaccttctt ctctttcctc tcctgacagg 840
ttggtaacca agccaccatg cagctgagaa accctgagct gcacctgggc tgtgctctgg 900
ccctgagatt tctggctctg gtgtcctggg acatccctgg tgctagagcc ctggataatg 960
gcctggccag aacacctaca atgggctggc tgcactggga gagattcatg tgcaacctgg 1020
actgccaaga ggaacctgac agctgcatct ctgagaagct gttcatggaa atggctgagc 1080
tgatggtgtc tgaaggctgg aaggatgctg gctatgagta cctgtgcatt gatgactgct 1140
ggatggcccc tcagagagac tctgaaggca gactccaggc tgaccctcag aggttccctc 1200
atggcatcag acagctggcc aactatgtgc acagcaaggg cctgaagctg ggcatctatg 1260
ctgatgtggg caacaagacc tgtgctggct tccctggcag ctttggctac tatgacattg 1320
atgcccagac ctttgctgac tggggagttg acctgctgaa gtttgatggc tgctactgtg 1380
acagcctgga aaacctggct gatggctaca agcacatgag cctggctctg aacagaacag 1440
gcagatccat tgtgtacagc tgtgaatggc ccctgtacat gtggcccttc cagaagccta 1500
actacacaga gatcagacag tactgcaacc attggaggaa ctttgctgat attgatgata 1560
gctggaagtc catcaagagc atcctggact ggaccagctt caatcaagaa aggattgtgg 1620
atgtggctgg ccctggtggc tggaatgacc ctgacatgct ggtcattggc aactttggcc 1680
tgagctggaa ccagcaagtg acccagatgg ccctgtgggc cattatggct gcccctctgt 1740
tcatgagcaa tgacctgaga cacatcagcc ctcaggctaa ggccctgctc caggacaagg 1800
atgtgattgc tatcaatcag gaccctctgg gcaagcaggg ctaccagctt agacagggag 1860
acaactttga agtgtgggaa agacccctgt ctggcctggc ttgggctgtt gccatgatca 1920
acagacaaga gattggaggc cccaggtcct acaccattgc tgtggccagc cttggcaaag 1980
gggttgcctg taatcctgcc tgcttcatca cccagctgct gcctgtgaag agaaagctgg 2040
gcttttatga gtggaccagc agactgagaa gccacatcaa ccccacaggc acagtgctgc 2100
tgcaactgga aaacacaatg cagatgtccc tgaaggacct gctgggtgga ggaggtagta 2160
gaaacacagg cagaggtgga gaggaaaaga agaaagagaa agaaaaagag gaacaagagg 2220
aaagggaaac taagacccct gagtgcccca gccacacaca gcctctggga gtgttcctgt 2280
ttcctccaaa gccaaaggac accctgatga tcagcagaac ccctgaagtg acctgtgtgg 2340
tggtggatgt gtcccaagag gacccagagg tgcagttcaa ttggtatgtg gatggtgttg 2400
aggtgcacaa tgccaagacc aagcctagag aggaacagtt caacagcacc tacagagtgg 2460
tgtctgtgct gacagtgctg caccaggact ggctgaatgg caaagagtac aagtgcaagg 2520
tgtccaacaa gggcctgcct agcagcattg aaaagaccat cagcaaggcc aagggccagc 2580
caagagaacc ccaggtgtac acactgcctc caagccaaga agagatgacc aagaaccagg 2640
tgtccctgac ctgcctggtc aagggcttct acccctctga cattgctgtg gaatgggaga 2700
gcaatggcca gcctgagaac aactacaaga ccacacctcc tgtgctggac tctgatggct 2760
cattcttcct gtacagcaga ctgacagtgg acaagagcag atggcaagag ggcaatgtgt 2820
tcagctgctc tgtgatgcat gaggccctgc acaaccacta cacccagaag tctctgagcc 2880
tgagcctggg caaatgaaga tctacttctg gctaataaaa gatcagagct ctagtgatct 2940
gtgtgttggt tttttgtgtc tgcattctag ctctagtgat cagcagttca acctgttgat 3000
agtatgtact aagctctcat gtttaatgta ctaagctctc atgtttaatg aactaaaccc 3060
tcatggctaa tgtactaagc tctcatggct aatgtactaa gctctcatgt ttcatgtact 3120
aagctctcat gtttgaacaa taaaattaat ataaatcagc aacttaaata gcctctaagg 3180
ttttaagttt tataagaaaa aaaagaatat ataaggcttt taaaggtttt aaggtttcct 3240
aggttatcct catatgagct cttagaaaaa ctcatccagc atcaaatgaa actgcaattt 3300
attcatatca ggattatcaa taccatattt ttgaaaaagt cttttctgta atgaaggaga 3360
aaactcaccc aggcagttcc ataggatggc aagatcctgg tatctgtctg caattccaac 3420
tcttccaaca tcaatacaac ctattaattt cccctcatca aaaataaggt tatcaagtga 3480
gaaatcacca tgagtgacca ctgaatctgg tgagaatggc aaaagattat gcatttcttt 3540
ccagacttgt tcaacaggcc agccatttct ctcatcatca aaatcactgg catcaaccaa 3600
accattattc attcttgatt gggcctgagc cagtctaaat actctatcag agttaaaagg 3660
acaattacaa acaggaatgg aatgcaatct tctcaggaac actgccaggg catcaacaat 3720
attttcacct gaatcaggat attcttccaa tacctggaat gctgttttcc ctgggatggc 3780
agtggtgagt aaccatgcat catcaggagt tctgataaaa tgcttgatgg ttggaagagg 3840
cataaattca gtcagccagt ttagtctgac catctcatct gtaacatcat tggcaacaga 3900
acctttgcca tgtttcagaa acaactctgg ggcatctggc ttcccataca atctatagat 3960
tgtggcacct gattgcccaa cattatctct agcccattta tacccatata aatcagcatc 4020
catgttggaa tttaatcttg gcctggagca agaggtttct ctttgaatat ggctcataca 4080
tgtgcacctc ctatagtgag ttgtattata ctatgcagat atactatgcc aatgtttaat 4140
tgtcag 4146
<210> 33
<211> 3953
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic
<400> 33
cactatgtgt taattaaaat tatctctaag gcatgtgaac tggctgtctt ggttttcatc 60
tgtacttcat ctgctacctc tgtgacctga aacatattta taattccatt aagctgtgca 120
tatgatagat ttatcatatg tattttcctt aaaggatttt tgtaagaact aattgaattg 180
atacctgtaa agtctttatc acactaccca ataaataata aatctctttg ttcagctctc 240
tgtttctata aatatgtacc agttttattg tttttagtgg tagtgatttt attctctttc 300
tatatatata cacacacatg tgtgcattca taaatatata caatttttat gaataaaaaa 360
ttattagcaa tcaatattga aaaccactga tttttgttta tgtgagcaaa cagcagatta 420
aaaggaattt gaattctcat agctagcagg agtcaatggg aaaaacccat tggagccaag 480
tacactgact caatagggac tttccattgg gttttgccca gtacataagg tcaatagggg 540
gtgagtcaac aggaaagtcc cattggagcc aagtacattg agtcaatagg gactttccaa 600
tgggttttgc ccagtacata aggtcaatgg gaggtaagcc aatgggtttt tcccattact 660
gacatgtata ctgagtcatt agggactttc caatgggttt tgcccagtac ataaggtcaa 720
taggggtgaa tcaacaggaa agtcccattg gagccaagta cactgagtca atagggactt 780
tccattgggt tttgcccagt acaaaaggtc aatagggggt gagtcaatgg gtttttccca 840
ttattggcac atacataagg tcaatagggg tgactagtgg agaagagcat gcttgagggc 900
tgagtgcccc tcagtgggca gagagcacat ggcccacagt ccctgagaag ttggggggag 960
gggtgggcaa ttgaactggt gcctagagaa ggtggggctt gggtaaactg ggaaagtgat 1020
gtggtgtact ggctccacct ttttccccag ggtgggggag aaccatatat aagtgcagta 1080
gtctctgtga acattcaagc ttctgccttc tccctcctgt gagtttggta agtcactgac 1140
tgtctatgcc tgggaaaggg tgggcaggag atggggcagt gcaggaaaag tggcactatg 1200
aaccctgcag ccctagacaa ttgtactaac cttcttctct ttcctctcct gacaggttgg 1260
taaccaagcc accatggctg gacctgccac ccagagcccc atgaagctga tggccctgca 1320
gctgctgctg tggcacagtg cactctggac agtgcaggaa gccacccccc tgggccctgc 1380
cagctccctg ccccagagct tcctgctcaa gtgcttagag caagtgagga agatccaggg 1440
ggatggggca gctctccagg agaagctgtg tgccacctac aagctgtgcc accctgagga 1500
gctggtgctg ctgggacact ctctgggcat cccctgggct cccctgagca gctgccccag 1560
ccaggccctg cagctggcag gctgcttgag ccaactccat agtggccttt tcctctacca 1620
ggggctcctg caggccctgg aagggatctc ccctgagttg ggtcccacct tggacacact 1680
gcagctggat gttgctgact ttgccaccac catctggcag cagatggaag aactgggaat 1740
ggcccctgcc ctgcagccca cccagggtgc catgcctgcc tttgcctctg ctttccagag 1800
aagggcagga ggggtcctgg ttgcctccca tctgcagagc ttcctggagg tgtcctacag 1860
agttctaaga caccttgccc agccctgata gatctacttc tggctaataa aagatcagag 1920
ctctagtgat ctgtgtgttg gttttttgtg tctgcattct agcaagtcaa tatgttcacc 1980
ccaaaaaagc tgtttgttaa cttgtcaacc tcattctaaa atgtatatag aagcccaaaa 2040
gacaataaca aaaatattct tgtagaacaa aatgggaaag aatgttccac taaatatcaa 2100
gatttagagc aaagcatgag atgtgtgggg atagacagtg aggctgataa aatagagtag 2160
agctcagaaa cagacccatt gatatatgta agtgacctat gaaaaaaata tggcatttta 2220
caatgggaaa atgatggtct ttttcttttt tagaaaaaca gggaaatata tttatatgta 2280
aaaaataaaa gggaacccat atgtcatacc atacacacaa aaaaattcca gtgaattata 2340
agtctaaatg gagaaggcaa aactttaaat cttttagaaa ataatataga agcatgccat 2400
caagacttca gtgtagagaa aaatttctta tgactcaaag tcctaaccac aaagaaaaga 2460
ttgttaatta gattgcatga atattaagac ttatttttaa aattaaaaaa ccattaagaa 2520
aagtcaggcc atagaatgac agaaaatatt tgcaacaccc cagtaaagag aattgtaata 2580
tgcagattat aaaaagaagt cttacaaatc agtaaaaaat aaaactagac aaaaatttga 2640
acagatgaaa gagaaactct aaataatcat tacacatgag aaactcaatc tcagaaatca 2700
gagaactatc attgcatata cactaaatta gagaaatatt aaaaggctaa gtaacatctg 2760
tggcttaatt aatctagctc tagtgatcag cagttcaacc tgttgatagt atgtactaag 2820
ctctcatgtt taatgtacta agctctcatg tttaatgaac taaaccctca tggctaatgt 2880
actaagctct catggctaat gtactaagct ctcatgtttc atgtactaag ctctcatgtt 2940
tgaacaataa aattaatata aatcagcaac ttaaatagcc tctaaggttt taagttttat 3000
aagaaaaaaa agaatatata aggcttttaa aggttttaag gtttcctagg ttatcctcat 3060
atgagctctt agaaaaactc atccagcatc aaatgaaact gcaatttatt catatcagga 3120
ttatcaatac catatttttg aaaaagtctt ttctgtaatg aaggagaaaa ctcacccagg 3180
cagttccata ggatggcaag atcctggtat ctgtctgcaa ttccaactct tccaacatca 3240
atacaaccta ttaatttccc ctcatcaaaa ataaggttat caagtgagaa atcaccatga 3300
gtgaccactg aatctggtga gaatggcaaa agattatgca tttctttcca gacttgttca 3360
acaggccagc catttctctc atcatcaaaa tcactggcat caaccaaacc attattcatt 3420
cttgattggg cctgagccag tctaaatact ctatcagagt taaaaggaca attacaaaca 3480
ggaatggaat gcaatcttct caggaacact gccagggcat caacaatatt ttcacctgaa 3540
tcaggatatt cttccaatac ctggaatgct gttttccctg ggatggcagt ggtgagtaac 3600
catgcatcat caggagttct gataaaatgc ttgatggttg gaagaggcat aaattcagtc 3660
agccagttta gtctgaccat ctcatctgta acatcattgg caacagaacc tttgccatgt 3720
ttcagaaaca actctggggc atctggcttc ccatacaatc tatagattgt ggcacctgat 3780
tgcccaacat tatctctagc ccatttatac ccatataaat cagcatccat gttggaattt 3840
aatcttggcc tggagcaaga ggtttctctt tgaatatggc tcatacatgt gcacctccta 3900
tagtgagttg tattatacta tgcagatata ctatgccaat gtttaattgt cag 3953
<210> 34
<211> 5011
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic
<400> 34
cactatgtgg acatgaattc aattggctag caggagtcaa tgggaaaaac ccattggagc 60
caagtacact gactcaatag ggactttcca ttgggttttg cccagtacat aaggtcaata 120
gggggtgagt caacaggaaa gtcccattgg agccaagtac attgagtcaa tagggacttt 180
ccaatgggtt ttgcccagta cataaggtca atgggaggta agccaatggg tttttcccat 240
tactgacatg tatactgagt cattagggac tttccaatgg gttttgccca gtacataagg 300
tcaatagggg tgaatcaaca ggaaagtccc attggagcca agtacactga gtcaataggg 360
actttccatt gggttttgcc cagtacaaaa ggtcaatagg gggtgagtca atgggttttt 420
cccattattg gcacatacat aaggtcaata ggggtgacta gtggagaaga gcatgcttga 480
gggctgagtg cccctcagtg ggcagagagc acatggccca cagtccctga gaagttgggg 540
ggaggggtgg gcaattgaac tggtgcctag agaaggtggg gcttgggtaa actgggaaag 600
tgatgtggtg tactggctcc acctttttcc ccagggtggg ggagaaccat atataagtgc 660
agtagtctct gtgaacattc aagcttctgc cttctccctc ctgtgagttt ggtaagtcac 720
tgactgtcta tgcctgggaa agggtgggca ggagatgggg cagtgcagga aaagtggcac 780
tatgaaccct gcagccctag acaattgtac taaccttctt ctctttcctc tcctgacagg 840
ttggtaacca agccaccatg ggctggtccc tgatcctgct gttcctggtg gctgtggcca 900
ccagagtgct gagccaggtg cagctgcagc agcctggggc tgagcttgtg aaacctgggg 960
cctctgtgaa gatgagctgc aaggcctctg gctacacctt caccagctac aacatgcact 1020
gggtcaagca gacccctggc agaggcctgg aatggattgg agccatctac cctggcaatg 1080
gggacacctc ctacaaccag aagttcaagg gcaaggccac cctgacagct gacaagagca 1140
gcagcacagc ctacatgcag ctgtccagcc tgacctctga ggactctgct gtgtactact 1200
gtgccaggtc cacctactat gggggagact ggtacttcaa tgtgtgggga gctggcacca 1260
cagtgacagt gtctgctgcc agcaccaagg gcccctctgt gtttcctctg gcccccagca 1320
gcaagagcac ctctggggga acagctgccc tgggctgcct tgtgaaggac tacttccctg 1380
agcctgtgac tgtgtcctgg aactctgggg ccctgacatc tggggtgcac accttccctg 1440
cagtgctgca gtccagtggc ctgtactccc tgtcctctgt tgtgacagtg cccagctcca 1500
gcctgggcac ccagacctac atctgcaatg tgaaccacaa gcccagcaac accaaggtgg 1560
acaagaaggc tgagcccaag agctgtgaca agacccacac ctgtcccccc tgtcctgccc 1620
ctgaactgct gggaggacct tctgtgttcc tgttcccacc caagcccaag gataccctga 1680
tgatcagcag aacccctgaa gtgacctgtg tggtggtgga tgtgtcccat gaggacccag 1740
aagtgaagtt caattggtat gtggatgggg tggaagtgca caatgccaag accaagccca 1800
gagaggaaca gtacaacagc acctacagag tggtgtctgt gctgactgtg ctgcaccagg 1860
actggctgaa tggcaaagag tacaagtgca aggtgtccaa caaggccctg ccagccccca 1920
ttgagaaaac catcagcaag gccaagggcc agcctagaga accccaggtg tacacactgc 1980
cccctagcag ggatgagctg accaagaacc aggtgtccct gacatgcctt gtgaaaggct 2040
tctacccctc tgacattgct gtggaatggg agagcaatgg acagcctgag aacaactaca 2100
agaccacccc ccctgtgctg gactctgatg gctcattctt cctgtacagc aagctgacag 2160
tggacaagtc cagatggcag cagggcaatg tgttcagctg ctctgtgatg catgaggccc 2220
tgcacaacca ctacacccag aaaagcctgt ccctgtcccc tggcaagtga agatctactt 2280
ctggctaata aaagatcaga gctctagtga tctgtgtgtt ggttttttgt gtctgcattc 2340
tagctgttac ataacttatg gtaaatggcc tgcctggctg actgcccaat gacccctgcc 2400
caatgatgtc aataatgatg tatgttccca tgtaatgcca atagggactt tccattgatg 2460
tcaatgggtg gagtatttat ggtaactgcc cacttggcag tacatcaagt gtatcatatg 2520
ccaagtatgc cccctattga tgtcaatgat ggtaaatggc ctgcctggca ttatgcccag 2580
tacatgacct tatgggactt tcctacttgg cagtacatct atgtattagt cattgctatt 2640
accatggatt agtggagaag agcatgcttg agggctgagt gcccctcagt gggcagagag 2700
cacatggccc acagtccctg agaagttggg gggaggggtg ggcaattgaa ctggtgccta 2760
gagaaggtgg ggcttgggta aactgggaaa gtgatgtggt gtactggctc cacctttttc 2820
cccagggtgg gggagaacca tatataagtg cagtagtctc tgtgaacatt caagcttctg 2880
ccttctccct cctgtgagtt tggatatcgt aagtcactga ctgtctatgc ctgggaaagg 2940
gtgggcagga gatggggcag tgcaggaaaa gtggcactat gaaccctgca gccctagaca 3000
attgtactaa ccttcttctc tttcctctcc tgacaggttg gtaaccaagc caccatggac 3060
ttccaggtgc agatcatcag ctttctgctg atctctgcct ctgtgatcat gagcagaggc 3120
cagattgtgc tgagccagag ccctgccatc ctgtctgcaa gccctgggga gaaagtgacc 3180
atgacctgca gagccagcag ctctgtgtcc tacatccact ggttccagca gaagcctggc 3240
agcagcccca agccttggat ctatgccacc agcaacctgg catctggggt gccagtcaga 3300
ttctctggct ctggatctgg caccagctac agcctgacca tcagcagagt ggaagctgag 3360
gatgctgcca cctactactg ccagcagtgg accagcaatc cccccacctt tggagggggc 3420
accaagctgg aaatcaagag aacagtggct gccccctctg tgttcatctt cccaccctct 3480
gatgagcagc tgaagtctgg aacagcctct gttgtgtgcc tgctgaacaa cttctacccc 3540
agagaagcca aggtgcagtg gaaggtggac aatgccctgc agtctggcaa ctcccaggaa 3600
tctgtgacag agcaggacag caaggactcc acctactccc tgagcagcac cctgaccctg 3660
agcaaggctg actatgagaa gcacaaagtg tatgcctgtg aagtgaccca ccagggcctg 3720
tccagccctg tgaccaagag cttcaacaga ggggagagct gaagatctac ttctggctaa 3780
taaaagatca gagctctagt gatctgtgtg ttggtttttt gtgtctgcat tctagctcta 3840
gtgatcagca gttcaacctg ttgatagtat gtactaagct ctcatgttta atgtactaag 3900
ctctcatgtt taatgaacta aaccctcatg gctaatgtac taagctctca tggctaatgt 3960
actaagctct catgtttcat gtactaagct ctcatgtttg aacaataaaa ttaatataaa 4020
tcagcaactt aaatagcctc taaggtttta agttttataa gaaaaaaaag aatatataag 4080
gcttttaaag gttttaaggt ttcctaggtt atcctcatat gagctcttag aaaaactcat 4140
ccagcatcaa atgaaactgc aatttattca tatcaggatt atcaatacca tatttttgaa 4200
aaagtctttt ctgtaatgaa ggagaaaact cacccaggca gttccatagg atggcaagat 4260
cctggtatct gtctgcaatt ccaactcttc caacatcaat acaacctatt aatttcccct 4320
catcaaaaat aaggttatca agtgagaaat caccatgagt gaccactgaa tctggtgaga 4380
atggcaaaag attatgcatt tctttccaga cttgttcaac aggccagcca tttctctcat 4440
catcaaaatc actggcatca accaaaccat tattcattct tgattgggcc tgagccagtc 4500
taaatactct atcagagtta aaaggacaat tacaaacagg aatggaatgc aatcttctca 4560
ggaacactgc cagggcatca acaatatttt cacctgaatc aggatattct tccaatacct 4620
ggaatgctgt tttccctggg atggcagtgg tgagtaacca tgcatcatca ggagttctga 4680
taaaatgctt gatggttgga agaggcataa attcagtcag ccagtttagt ctgaccatct 4740
catctgtaac atcattggca acagaacctt tgccatgttt cagaaacaac tctggggcat 4800
ctggcttccc atacaatcta tagattgtgg cacctgattg cccaacatta tctctagccc 4860
atttataccc atataaatca gcatccatgt tggaatttaa tcttggcctg gagcaagagg 4920
tttctctttg aatatggctc atacatgtgc acctcctata gtgagttgta ttatactatg 4980
cagatatact atgccaatgt ttaattgtca g 5011
<210> 35
<211> 7288
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic
<400> 35
cactatgtgg acatgaattc aattggctag ctgttacata acttatggta aatggcctgc 60
ctggctgact gcccaatgac ccctgcccaa tgatgtcaat aatgatgtat gttcccatgt 120
aatgccaata gggactttcc attgatgtca atgggtggag tatttatggt aactgcccac 180
ttggcagtac atcaagtgta tcatatgcca agtatgcccc ctattgatgt caatgatggt 240
aaatggcctg cctggcatta tgcccagtac atgaccttat gggactttcc tacttggcag 300
tacatctatg tattagtcat tgctattacc atggattagt ggagaagagc atgcttgagg 360
gctgagtgcc cctcagtggg cagagagcac atggcccaca gtccctgaga agttgggggg 420
aggggtgggc aattgaactg gtgcctagag aaggtggggc ttgggtaaac tgggaaagtg 480
atgtggtgta ctggctccac ctttttcccc agggtggggg agaaccatat ataagtgcag 540
tagtctctgt gaacattcaa gcttctgcct tctccctcct gtgagtttgg atatcgtaag 600
tcactgactg tctatgcctg ggaaagggtg ggcaggagat ggggcagtgc aggaaaagtg 660
gcactatgaa ccctgcagcc ctagacaatt gtactaacct tcttctcttt cctctcctga 720
caggttggta accaagccac catgggctgg tccctgatcc tgctgttcct ggtggctgtg 780
gccaccagag tgctgagcca ggtgcagctg cagcagcctg gggctgagct tgtgaaacct 840
ggggcctctg tgaagatgag ctgcaaggcc tctggctaca ccttcaccag ctacaacatg 900
cactgggtca agcagacccc tggcagaggc ctggaatgga ttggagccat ctaccctggc 960
aatggggaca cctcctacaa ccagaagttc aagggcaagg ccaccctgac agctgacaag 1020
agcagcagca cagcctacat gcagctgtcc agcctgacct ctgaggactc tgctgtgtac 1080
tactgtgcca ggtccaccta ctatggggga gactggtact tcaatgtgtg gggagctggc 1140
accacagtga cagtgtctgc tgccagcacc aagggcccct ctgtgtttcc tctggccccc 1200
agcagcaaga gcacctctgg gggaacagct gccctgggct gccttgtgaa ggactacttc 1260
cctgagcctg tgactgtgtc ctggaactct ggggccctga catctggggt gcacaccttc 1320
cctgcagtgc tgcagtccag tggcctgtac tccctgtcct ctgttgtgac agtgcccagc 1380
tccagcctgg gcacccagac ctacatctgc aatgtgaacc acaagcccag caacaccaag 1440
gtggacaaga aggctgagcc caagagctgt gacaagaccc acacctgtcc cccctgtcct 1500
gcccctgaac tgctgggagg accttctgtg ttcctgttcc cacccaagcc caaggatacc 1560
ctgatgatca gcagaacccc tgaagtgacc tgtgtggtgg tggatgtgtc ccatgaggac 1620
ccagaagtga agttcaattg gtatgtggat ggggtggaag tgcacaatgc caagaccaag 1680
cccagagagg aacagtacaa cagcacctac agagtggtgt ctgtgctgac tgtgctgcac 1740
caggactggc tgaatggcaa agagtacaag tgcaaggtgt ccaacaaggc cctgccagcc 1800
cccattgaga aaaccatcag caaggccaag ggccagccta gagaacccca ggtgtacaca 1860
ctgcccccta gcagggatga gctgaccaag aaccaggtgt ccctgacatg ccttgtgaaa 1920
ggcttctacc cctctgacat tgctgtggaa tgggagagca atggacagcc tgagaacaac 1980
tacaagacca ccccccctgt gctggactct gatggctcat tcttcctgta cagcaagctg 2040
acagtggaca agtccagatg gcagcagggc aatgtgttca gctgctctgt gatgcatgag 2100
gccctgcaca accactacac ccagaaaagc ctgtccctgt cccctggcaa gagaaagaga 2160
aggagtggaa gtggagctac taacttcagc ctgctgaagc aggctggaga tgtggaggag 2220
aaccctggac ctatggactt ccaggtgcag atcatcagct ttctgctgat ctctgcctct 2280
gtgatcatga gcagaggcca gattgtgctg agccagagcc ctgccatcct gtctgcaagc 2340
cctggggaga aagtgaccat gacctgcaga gccagcagct ctgtgtccta catccactgg 2400
ttccagcaga agcctggcag cagccccaag ccttggatct atgccaccag caacctggca 2460
tctggggtgc cagtcagatt ctctggctct ggatctggca ccagctacag cctgaccatc 2520
agcagagtgg aagctgagga tgctgccacc tactactgcc agcagtggac cagcaatccc 2580
cccacctttg gagggggcac caagctggaa atcaagagaa cagtggctgc cccctctgtg 2640
ttcatcttcc caccctctga tgagcagctg aagtctggaa cagcctctgt tgtgtgcctg 2700
ctgaacaact tctaccccag agaagccaag gtgcagtgga aggtggacaa tgccctgcag 2760
tctggcaact cccaggaatc tgtgacagag caggacagca aggactccac ctactccctg 2820
agcagcaccc tgaccctgag caaggctgac tatgagaagc acaaagtgta tgcctgtgaa 2880
gtgacccacc agggcctgtc cagccctgtg accaagagct tcaacagagg ggagagctga 2940
agatctactt ctggctaata aaagatcaga gctctagtga tctgtgtgtt ggttttttgt 3000
gtctgcattc tagcaggagt caatgggaaa aacccattgg agccaagtac actgactcaa 3060
tagggacttt ccattgggtt ttgcccagta cataaggtca atagggggtg agtcaacagg 3120
aaagtcccat tggagccaag tacattgagt caatagggac tttccaatgg gttttgccca 3180
gtacataagg tcaatgggag gtaagccaat gggtttttcc cattactgac atgtatactg 3240
agtcattagg gactttccaa tgggttttgc ccagtacata aggtcaatag gggtgaatca 3300
acaggaaagt cccattggag ccaagtacac tgagtcaata gggactttcc attgggtttt 3360
gcccagtaca aaaggtcaat agggggtgag tcaatgggtt tttcccatta ttggcacata 3420
cataaggtca ataggggtga ctagtggaga agagcatgct tgagggctga gtgcccctca 3480
gtgggcagag agcacatggc ccacagtccc tgagaagttg gggggagggg tgggcaattg 3540
aactggtgcc tagagaaggt ggggcttggg taaactggga aagtgatgtg gtgtactggc 3600
tccacctttt tccccagggt gggggagaac catatataag tgcagtagtc tctgtgaaca 3660
ttcaagcttc tgccttctcc ctcctgtgag tttggtaagt cactgactgt ctatgcctgg 3720
gaaagggtgg gcaggagatg gggcagtgca ggaaaagtgg cactatgaac cctgcagccc 3780
tagacaattg tactaacctt cttctctttc ctctcctgac aggttggtaa ccaagccacc 3840
atgggctggt ccctgatcct gctgttcctg gtggctgtgg ccaccagagt gctgagccag 3900
gtgcagctgc agcagcctgg ggctgagctt gtgaaacctg gggcctctgt gaagatgagc 3960
tgcaaggcct ctggctacac cttcaccagc tacaacatgc actgggtcaa gcagacccct 4020
ggcagaggcc tggaatggat tggagccatc taccctggca atggggacac ctcctacaac 4080
cagaagttca agggcaaggc caccctgaca gctgacaaga gcagcagcac agcctacatg 4140
cagctgtcca gcctgacctc tgaggactct gctgtgtact actgtgccag gtccacctac 4200
tatgggggag actggtactt caatgtgtgg ggagctggca ccacagtgac agtgtctgct 4260
gccagcacca agggcccctc tgtgtttcct ctggccccca gcagcaagag cacctctggg 4320
ggaacagctg ccctgggctg ccttgtgaag gactacttcc ctgagcctgt gactgtgtcc 4380
tggaactctg gggccctgac atctggggtg cacaccttcc ctgcagtgct gcagtccagt 4440
ggcctgtact ccctgtcctc tgttgtgaca gtgcccagct ccagcctggg cacccagacc 4500
tacatctgca atgtgaacca caagcccagc aacaccaagg tggacaagaa ggctgagccc 4560
aagagctgtg acaagaccca cacctgtccc ccctgtcctg cccctgaact gctgggagga 4620
ccttctgtgt tcctgttccc acccaagccc aaggataccc tgatgatcag cagaacccct 4680
gaagtgacct gtgtggtggt ggatgtgtcc catgaggacc cagaagtgaa gttcaattgg 4740
tatgtggatg gggtggaagt gcacaatgcc aagaccaagc ccagagagga acagtacaac 4800
agcacctaca gagtggtgtc tgtgctgact gtgctgcacc aggactggct gaatggcaaa 4860
gagtacaagt gcaaggtgtc caacaaggcc ctgccagccc ccattgagaa aaccatcagc 4920
aaggccaagg gccagcctag agaaccccag gtgtacacac tgccccctag cagggatgag 4980
ctgaccaaga accaggtgtc cctgacatgc cttgtgaaag gcttctaccc ctctgacatt 5040
gctgtggaat gggagagcaa tggacagcct gagaacaact acaagaccac cccccctgtg 5100
ctggactctg atggctcatt cttcctgtac agcaagctga cagtggacaa gtccagatgg 5160
cagcagggca atgtgttcag ctgctctgtg atgcatgagg ccctgcacaa ccactacacc 5220
cagaaaagcc tgtccctgtc ccctggcaag agaaagagaa ggagtggaag tggagctact 5280
aacttcagcc tgctgaagca ggctggagat gtggaggaga accctggacc tatggacttc 5340
caggtgcaga tcatcagctt tctgctgatc tctgcctctg tgatcatgag cagaggccag 5400
attgtgctga gccagagccc tgccatcctg tctgcaagcc ctggggagaa agtgaccatg 5460
acctgcagag ccagcagctc tgtgtcctac atccactggt tccagcagaa gcctggcagc 5520
agccccaagc cttggatcta tgccaccagc aacctggcat ctggggtgcc agtcagattc 5580
tctggctctg gatctggcac cagctacagc ctgaccatca gcagagtgga agctgaggat 5640
gctgccacct actactgcca gcagtggacc agcaatcccc ccacctttgg agggggcacc 5700
aagctggaaa tcaagagaac agtggctgcc ccctctgtgt tcatcttccc accctctgat 5760
gagcagctga agtctggaac agcctctgtt gtgtgcctgc tgaacaactt ctaccccaga 5820
gaagccaagg tgcagtggaa ggtggacaat gccctgcagt ctggcaactc ccaggaatct 5880
gtgacagagc aggacagcaa ggactccacc tactccctga gcagcaccct gaccctgagc 5940
aaggctgact atgagaagca caaagtgtat gcctgtgaag tgacccacca gggcctgtcc 6000
agccctgtga ccaagagctt caacagaggg gagagctgaa gatctacttc tggctaataa 6060
aagatcagag ctctagtgat ctgtgtgttg gttttttgtg tctgcattct agctctagtg 6120
atcagcagtt caacctgttg atagtatgta ctaagctctc atgtttaatg tactaagctc 6180
tcatgtttaa tgaactaaac cctcatggct aatgtactaa gctctcatgg ctaatgtact 6240
aagctctcat gtttcatgta ctaagctctc atgtttgaac aataaaatta atataaatca 6300
gcaacttaaa tagcctctaa ggttttaagt tttataagaa aaaaaagaat atataaggct 6360
tttaaaggtt ttaaggtttc ctaggttatc ctcatatgag ctcttagaaa aactcatcca 6420
gcatcaaatg aaactgcaat ttattcatat caggattatc aataccatat ttttgaaaaa 6480
gtcttttctg taatgaagga gaaaactcac ccaggcagtt ccataggatg gcaagatcct 6540
ggtatctgtc tgcaattcca actcttccaa catcaataca acctattaat ttcccctcat 6600
caaaaataag gttatcaagt gagaaatcac catgagtgac cactgaatct ggtgagaatg 6660
gcaaaagatt atgcatttct ttccagactt gttcaacagg ccagccattt ctctcatcat 6720
caaaatcact ggcatcaacc aaaccattat tcattcttga ttgggcctga gccagtctaa 6780
atactctatc agagttaaaa ggacaattac aaacaggaat ggaatgcaat cttctcagga 6840
acactgccag ggcatcaaca atattttcac ctgaatcagg atattcttcc aatacctgga 6900
atgctgtttt ccctgggatg gcagtggtga gtaaccatgc atcatcagga gttctgataa 6960
aatgcttgat ggttggaaga ggcataaatt cagtcagcca gtttagtctg accatctcat 7020
ctgtaacatc attggcaaca gaacctttgc catgtttcag aaacaactct ggggcatctg 7080
gcttcccata caatctatag attgtggcac ctgattgccc aacattatct ctagcccatt 7140
tatacccata taaatcagca tccatgttgg aatttaatct tggcctggag caagaggttt 7200
ctctttgaat atggctcata catgtgcacc tcctatagtg agttgtatta tactatgcag 7260
atatactatg ccaatgttta attgtcag 7288
<210> 36
<211> 8634
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic
<400> 36
cactatgtgt taattaaaat tatctctaag gcatgtgaac tggctgtctt ggttttcatc 60
tgtacttcat ctgctacctc tgtgacctga aacatattta taattccatt aagctgtgca 120
tatgatagat ttatcatatg tattttcctt aaaggatttt tgtaagaact aattgaattg 180
atacctgtaa agtctttatc acactaccca ataaataata aatctctttg ttcagctctc 240
tgtttctata aatatgtacc agttttattg tttttagtgg tagtgatttt attctctttc 300
tatatatata cacacacatg tgtgcattca taaatatata caatttttat gaataaaaaa 360
ttattagcaa tcaatattga aaaccactga tttttgttta tgtgagcaaa cagcagatta 420
aaaggaattt gaattctcat agctagcagg agtcaatggg aaaaacccat tggagccaag 480
tacactgact caatagggac tttccattgg gttttgccca gtacataagg tcaatagggg 540
gtgagtcaac aggaaagtcc cattggagcc aagtacattg agtcaatagg gactttccaa 600
tgggttttgc ccagtacata aggtcaatgg gaggtaagcc aatgggtttt tcccattact 660
gacatgtata ctgagtcatt agggactttc caatgggttt tgcccagtac ataaggtcaa 720
taggggtgaa tcaacaggaa agtcccattg gagccaagta cactgagtca atagggactt 780
tccattgggt tttgcccagt acaaaaggtc aatagggggt gagtcaatgg gtttttccca 840
ttattggcac atacataagg tcaatagggg tgactagtgg agaagagcat gcttgagggc 900
tgagtgcccc tcagtgggca gagagcacat ggcccacagt ccctgagaag ttggggggag 960
gggtgggcaa ttgaactggt gcctagagaa ggtggggctt gggtaaactg ggaaagtgat 1020
gtggtgtact ggctccacct ttttccccag ggtgggggag aaccatatat aagtgcagta 1080
gtctctgtga acattcaagc ttctgccttc tccctcctgt gagtttggta agtcactgac 1140
tgtctatgcc tgggaaaggg tgggcaggag atggggcagt gcaggaaaag tggcactatg 1200
aaccctgcag ccctagacaa ttgtactaac cttcttctct ttcctctcct gacaggttgg 1260
taaccaagcc accatgggat ggtccctgat cctgctgttt ctggtggctg tggccaccag 1320
agtgctgtct gaagtgcagc tggtggaatc tggccctggc ctggttaagc cctctgacat 1380
cctgagcctg acctgtgctg tgtctggcta cagcatcagc agcaactact actggggctg 1440
gatcagacag cctcctggca aaggcctgga atggattggc agcatctacc actctggctc 1500
cacctactac aagcccagcc tggaaagcag actgggcatc tctgtggaca ccagcaagaa 1560
ccagttcagc ctgaagctga gctttgtgtc tgctgctgac actgctgtgt actactgtgc 1620
cagacatgtt aggagtggct accctgacac agcctactac tttgataagt ggggccaggg 1680
caccctggtc acagtgtctg cttctacaaa gggcccctct gtgttcccac tggctcctag 1740
cagcaagagc accagtggtg gaacagctgc cctgggctgt ctggtcaagg actactttcc 1800
tgagccagtg acagtgtcct ggaactctgg ggctctgact tctggggtgc acacattccc 1860
tgctgtgctc cagtcctctg gcctgtacag cctgtcctct gtggtcactg tgccaagctc 1920
tagcctgggc acccagacct acatctgcaa tgtgaaccac aagcctagca acaccaaggt 1980
ggacaagaag gctgagccca agagctgtga caagacccac acctgtcctc catgtcctgc 2040
tccagagctg cttggaggac cttctgtgtt tctgttccct ccaaagccaa aggacaccct 2100
gatgatcagc agaacccctg aagtgacctg tgtggtggtg gatgtgtccc atgaggaccc 2160
agaagtgaag ttcaattggt atgtggatgg tgttgaggtg cacaatgcca agaccaagcc 2220
tagagaggaa cagtacaaca gcacctacag ggttgtgtca gtgctgactg tgctgcacca 2280
ggactggctg aatggcaaag agtacaagtg caaggtgtcc aacaaggccc tgcctgctcc 2340
tattgaaaag accatcagca aggccaaggg acagcctagg gaaccccagg tgtacacact 2400
gccacctagc agagatgagc tgaccaagaa tcaggtgtcc ctgacatgcc ttgtgaaggg 2460
cttctaccct tctgacattg cagtggaatg ggagagcaat ggccagcctg agaacaacta 2520
caagacaacc cctcctgtgc tggactctga tggctcattc ttcctgtact ccaagctgac 2580
agtggacaag tccagatggc agcaaggcaa tgtgttcagc tgctctgtga tgcatgaggc 2640
cctgcacaac cactacacac agaagtccct gtctctgagc cctggcaaga gaaagagaag 2700
gagtggatct ggggccacca acttcagcct gctgaaacag gctggggatg ttgaagagaa 2760
ccctggacct atggcctggg ctctgctgct tctgggactg ctgtctcact gcacaggcag 2820
tgtgaccagc tatgtgctga cccagcctcc atctgtgtct gtggctccag gggagacagc 2880
cagaatcagc tgtggtggca acaacattgg cacaaaggtg ctgcactggt atcagcagac 2940
tccaggacag gcaccagtgc tggtggtgta tgatgactct gacagaccct ctggcatccc 3000
agagaggttc tctggcagca actctggcaa cacagccaca ctgaccatct ccagagtgga 3060
agttggagat gaggctgatt actactgcca agtgtgggac atcagcacag accaggctgt 3120
gtttggtggt ggcaccaagc tcactgtgct gggccaacct aaagctgccc cttctgtgac 3180
actgttccca cctagctctg aggaactcca ggctaacaag gccacacttg tgtgcctgat 3240
cagtgacttc tacccagggg ctgtgactgt ggcctggaag gctgatagca gccctgtgaa 3300
ggctggggtt gagacaacca cacctagcaa gcagagcaac aacaaatatg ctgccagcag 3360
ctacctgagt ctgacccctg agcagtggaa gtcccacaga tcctacagct gtcaagtgac 3420
ccatgagggc tccacagtgg aaaagacagt ggcccctaca gagtgctcct gaagatctac 3480
ttctggctaa taaaagatca gagctctagt gatctgtgtg ttggtttttt gtgtctgcat 3540
tctagcagga gtcaatggga aaaacccatt ggagccaagt acactgactc aatagggact 3600
ttccattggg ttttgcccag tacataaggt caataggggg tgagtcaaca ggaaagtccc 3660
attggagcca agtacattga gtcaataggg actttccaat gggttttgcc cagtacataa 3720
ggtcaatggg aggtaagcca atgggttttt cccattactg acatgtatac tgagtcatta 3780
gggactttcc aatgggtttt gcccagtaca taaggtcaat aggggtgaat caacaggaaa 3840
gtcccattgg agccaagtac actgagtcaa tagggacttt ccattgggtt ttgcccagta 3900
caaaaggtca atagggggtg agtcaatggg tttttcccat tattggcaca tacataaggt 3960
caataggggt gactagtgga gaagagcatg cttgagggct gagtgcccct cagtgggcag 4020
agagcacatg gcccacagtc cctgagaagt tggggggagg ggtgggcaat tgaactggtg 4080
cctagagaag gtggggcttg ggtaaactgg gaaagtgatg tggtgtactg gctccacctt 4140
tttccccagg gtgggggaga accatatata agtgcagtag tctctgtgaa cattcaagct 4200
tctgccttct ccctcctgtg agtttggtaa gtcactgact gtctatgcct gggaaagggt 4260
gggcaggaga tggggcagtg caggaaaagt ggcactatga accctgcagc cctagacaat 4320
tgtactaacc ttcttctctt tcctctcctg acaggttggt aaccaagcca ccatgggatg 4380
gtccctgatc ctgctgtttc tggtggctgt ggccaccaga gtgctgtctg aagtgcagct 4440
ggtggaatct ggccctggcc tggttaagcc ctctgacatc ctgagcctga cctgtgctgt 4500
gtctggctac agcatcagca gcaactacta ctggggctgg atcagacagc ctcctggcaa 4560
aggcctggaa tggattggca gcatctacca ctctggctcc acctactaca agcccagcct 4620
ggaaagcaga ctgggcatct ctgtggacac cagcaagaac cagttcagcc tgaagctgag 4680
ctttgtgtct gctgctgaca ctgctgtgta ctactgtgcc agacatgtta ggagtggcta 4740
ccctgacaca gcctactact ttgataagtg gggccagggc accctggtca cagtgtctgc 4800
ttctacaaag ggcccctctg tgttcccact ggctcctagc agcaagagca ccagtggtgg 4860
aacagctgcc ctgggctgtc tggtcaagga ctactttcct gagccagtga cagtgtcctg 4920
gaactctggg gctctgactt ctggggtgca cacattccct gctgtgctcc agtcctctgg 4980
cctgtacagc ctgtcctctg tggtcactgt gccaagctct agcctgggca cccagaccta 5040
catctgcaat gtgaaccaca agcctagcaa caccaaggtg gacaagaagg ctgagcccaa 5100
gagctgtgac aagacccaca cctgtcctcc atgtcctgct ccagagctgc ttggaggacc 5160
ttctgtgttt ctgttccctc caaagccaaa ggacaccctg atgatcagca gaacccctga 5220
agtgacctgt gtggtggtgg atgtgtccca tgaggaccca gaagtgaagt tcaattggta 5280
tgtggatggt gttgaggtgc acaatgccaa gaccaagcct agagaggaac agtacaacag 5340
cacctacagg gttgtgtcag tgctgactgt gctgcaccag gactggctga atggcaaaga 5400
gtacaagtgc aaggtgtcca acaaggccct gcctgctcct attgaaaaga ccatcagcaa 5460
ggccaaggga cagcctaggg aaccccaggt gtacacactg ccacctagca gagatgagct 5520
gaccaagaat caggtgtccc tgacatgcct tgtgaagggc ttctaccctt ctgacattgc 5580
agtggaatgg gagagcaatg gccagcctga gaacaactac aagacaaccc ctcctgtgct 5640
ggactctgat ggctcattct tcctgtactc caagctgaca gtggacaagt ccagatggca 5700
gcaaggcaat gtgttcagct gctctgtgat gcatgaggcc ctgcacaacc actacacaca 5760
gaagtccctg tctctgagcc ctggcaagag aaagagaagg agtggatctg gggccaccaa 5820
cttcagcctg ctgaaacagg ctggggatgt tgaagagaac cctggaccta tggcctgggc 5880
tctgctgctt ctgggactgc tgtctcactg cacaggcagt gtgaccagct atgtgctgac 5940
ccagcctcca tctgtgtctg tggctccagg ggagacagcc agaatcagct gtggtggcaa 6000
caacattggc acaaaggtgc tgcactggta tcagcagact ccaggacagg caccagtgct 6060
ggtggtgtat gatgactctg acagaccctc tggcatccca gagaggttct ctggcagcaa 6120
ctctggcaac acagccacac tgaccatctc cagagtggaa gttggagatg aggctgatta 6180
ctactgccaa gtgtgggaca tcagcacaga ccaggctgtg tttggtggtg gcaccaagct 6240
cactgtgctg ggccaaccta aagctgcccc ttctgtgaca ctgttcccac ctagctctga 6300
ggaactccag gctaacaagg ccacacttgt gtgcctgatc agtgacttct acccaggggc 6360
tgtgactgtg gcctggaagg ctgatagcag ccctgtgaag gctggggttg agacaaccac 6420
acctagcaag cagagcaaca acaaatatgc tgccagcagc tacctgagtc tgacccctga 6480
gcagtggaag tcccacagat cctacagctg tcaagtgacc catgagggct ccacagtgga 6540
aaagacagtg gcccctacag agtgctcctg aagatctact tctggctaat aaaagatcag 6600
agctctagtg atctgtgtgt tggttttttg tgtctgcatt ctagcagtca atatgttcac 6660
cccaaaaaag ctgtttgtta acttgtcaac ctcattctaa aatgtatata gaagcccaaa 6720
agacaataac aaaaatattc ttgtagaaca aaatgggaaa gaatgttcca ctaaatatca 6780
agatttagag caaagcatga gatgtgtggg gatagacagt gaggctgata aaatagagta 6840
gagctcagaa acagacccat tgatatatgt aagtgaccta tgaaaaaaat atggcatttt 6900
acaatgggaa aatgatggtc tttttctttt ttagaaaaac agggaaatat atttatatgt 6960
aaaaaataaa agggaaccca tatgtcatac catacacaca aaaaaattcc agtgaattat 7020
aagtctaaat ggagaaggca aaactttaaa tcttttagaa aataatatag aagcatgcca 7080
tcaagacttc agtgtagaga aaaatttctt atgactcaaa gtcctaacca caaagaaaag 7140
attgttaatt agattgcatg aatattaaga cttattttta aaattaaaaa accattaaga 7200
aaagtcaggc catagaatga cagaaaatat ttgcaacacc ccagtaaaga gaattgtaat 7260
atgcagatta taaaaagaag tcttacaaat cagtaaaaaa taaaactaga caaaaatttg 7320
aacagatgaa agagaaactc taaataatca ttacacatga gaaactcaat ctcagaaatc 7380
agagaactat cattgcatat acactaaatt agagaaatat taaaaggcta agtaacatct 7440
gtggcttaat taatctagct ctagtgatca gcagttcaac ctgttgatag tatgtactaa 7500
gctctcatgt ttaatgtact aagctctcat gtttaatgaa ctaaaccctc atggctaatg 7560
tactaagctc tcatggctaa tgtactaagc tctcatgttt catgtactaa gctctcatgt 7620
ttgaacaata aaattaatat aaatcagcaa cttaaatagc ctctaaggtt ttaagtttta 7680
taagaaaaaa aagaatatat aaggctttta aaggttttaa ggtttcctag gttatcctca 7740
tatgagctct tagaaaaact catccagcat caaatgaaac tgcaatttat tcatatcagg 7800
attatcaata ccatattttt gaaaaagtct tttctgtaat gaaggagaaa actcacccag 7860
gcagttccat aggatggcaa gatcctggta tctgtctgca attccaactc ttccaacatc 7920
aatacaacct attaatttcc cctcatcaaa aataaggtta tcaagtgaga aatcaccatg 7980
agtgaccact gaatctggtg agaatggcaa aagattatgc atttctttcc agacttgttc 8040
aacaggccag ccatttctct catcatcaaa atcactggca tcaaccaaac cattattcat 8100
tcttgattgg gcctgagcca gtctaaatac tctatcagag ttaaaaggac aattacaaac 8160
aggaatggaa tgcaatcttc tcaggaacac tgccagggca tcaacaatat tttcacctga 8220
atcaggatat tcttccaata cctggaatgc tgttttccct gggatggcag tggtgagtaa 8280
ccatgcatca tcaggagttc tgataaaatg cttgatggtt ggaagaggca taaattcagt 8340
cagccagttt agtctgacca tctcatctgt aacatcattg gcaacagaac ctttgccatg 8400
tttcagaaac aactctgggg catctggctt cccatacaat ctatagattg tggcacctga 8460
ttgcccaaca ttatctctag cccatttata cccatataaa tcagcatcca tgttggaatt 8520
taatcttggc ctggagcaag aggtttctct ttgaatatgg ctcatacatg tgcacctcct 8580
atagtgagtt gtattatact atgcagatat actatgccaa tgtttaattg tcag 8634
<210> 37
<211> 8658
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic
<400> 37
cactatgtgt taattaaaat tatctctaag gcatgtgaac tggctgtctt ggttttcatc 60
tgtacttcat ctgctacctc tgtgacctga aacatattta taattccatt aagctgtgca 120
tatgatagat ttatcatatg tattttcctt aaaggatttt tgtaagaact aattgaattg 180
atacctgtaa agtctttatc acactaccca ataaataata aatctctttg ttcagctctc 240
tgtttctata aatatgtacc agttttattg tttttagtgg tagtgatttt attctctttc 300
tatatatata cacacacatg tgtgcattca taaatatata caatttttat gaataaaaaa 360
ttattagcaa tcaatattga aaaccactga tttttgttta tgtgagcaaa cagcagatta 420
aaaggaattt gaattctcat agctagcagg agtcaatggg aaaaacccat tggagccaag 480
tacactgact caatagggac tttccattgg gttttgccca gtacataagg tcaatagggg 540
gtgagtcaac aggaaagtcc cattggagcc aagtacattg agtcaatagg gactttccaa 600
tgggttttgc ccagtacata aggtcaatgg gaggtaagcc aatgggtttt tcccattact 660
gacatgtata ctgagtcatt agggactttc caatgggttt tgcccagtac ataaggtcaa 720
taggggtgaa tcaacaggaa agtcccattg gagccaagta cactgagtca atagggactt 780
tccattgggt tttgcccagt acaaaaggtc aatagggggt gagtcaatgg gtttttccca 840
ttattggcac atacataagg tcaatagggg tgactagtgg agaagagcat gcttgagggc 900
tgagtgcccc tcagtgggca gagagcacat ggcccacagt ccctgagaag ttggggggag 960
gggtgggcaa ttgaactggt gcctagagaa ggtggggctt gggtaaactg ggaaagtgat 1020
gtggtgtact ggctccacct ttttccccag ggtgggggag aaccatatat aagtgcagta 1080
gtctctgtga acattcaagc ttctgccttc tccctcctgt gagtttggta agtcactgac 1140
tgtctatgcc tgggaaaggg tgggcaggag atggggcagt gcaggaaaag tggcactatg 1200
aaccctgcag ccctagacaa ttgtactaac cttcttctct ttcctctcct gacaggttgg 1260
taaccaagcc accatggtcc tccagacaca ggtgttcatc agcctgctgc tgtggatcag 1320
tggtgcctat ggacaggtcc agctgcaaga gtctggccct ggacttgtca gacccagcca 1380
gacactgagc ctgacctgta cagtctctgg cttcagcctg accagctact ctgtgcactg 1440
ggtcagacag cctccaggca gaggactgga atggctggga gtgatctggg ccagtggtgg 1500
cacagactac aactctgccc tgatgagcag actgagcatc ctgaaggaca acagcaagaa 1560
ccaggtgtcc ctgagactgt cctctgtgac agctgctgat acagctgtgt acttctgtgc 1620
cagagatcct cctagctctc tgctgagact ggactactgg ggccagggca caacagtgac 1680
agtgtccagt gccagcacaa agggcccctc tgtgtttcct ctggctccca gcagcaagag 1740
caccagtggt ggaactgctg ccctgggctg tctggtcaag gactactttc ctgagcctgt 1800
gactgtgtcc tggaactctg gggctctgac atctggggtg cacacattcc ctgctgtgct 1860
gcaatcctct ggcctgtaca gcctcagctc tgtggtcaca gtgcctagct ctagcctggg 1920
cacccagacc tacatctgca atgtgaacca caagcctagc aacaccaagg tggacaagaa 1980
ggctgagccc aagagctgtg acaagaccca cacctgtcct ccatgtcctg ctccagagct 2040
gcttggagga cccagtgtgt tcctgtttcc tccaaagcca aaggacaccc tgatgatcag 2100
cagaacccct gaagtgacct gtgtggtggt ggatgtgtcc catgaggacc ctgaagtcaa 2160
gttcaattgg tatgtggatg gtgttgaggt gcacaatgcc aagaccaagc ctagagagga 2220
acagtacaac agcacctaca gagtggtgtc agtgctgaca gtgctgcacc aggactggct 2280
gaatggcaaa gagtacaagt gcaaggtgtc caacaaggcc ctgcctgctc ctattgaaaa 2340
gaccatcagc aaggccaagg gccagcctag ggaaccccag gtttacacac tgccacctag 2400
cagagatgag ctgaccaaaa atcaggtttc cctgacctgc ctggttaagg gcttctaccc 2460
ctctgacatt gctgtggaat gggagagcaa tggccagcct gagaacaact acaagacaac 2520
ccctcctgtg ctggactctg atggctcatt cttcctgtac tccaagctga ctgtggacaa 2580
aagcagatgg cagcaaggca atgtgttcag ctgctctgtg atgcatgagg ccctgcacaa 2640
ccactacacc cagaagtccc tgtctctgag ccctggcaag agaaagagaa ggagtggctc 2700
tggggccacc aactttagcc tgctgaaaca ggctggggat gttgaagaga accctggacc 2760
tatggtgctg caaacccagg ttttcatttc tctgctcctc tggattagtg gtgcttatgg 2820
ggacattgtg atgacacaga gccctagcag cctgtctgcc tctgtgggag acagagtgac 2880
catcacatgc aagtccagcc agagtctgct gaactctggc aaccagaaga actacctggc 2940
ctggtatcag caaaagcctg gcaaggcccc taagctgctc atctatgggg ccagcaccag 3000
agagtctggg gtcccagata gattctctgg ctctggatct ggcactgact tcaccttcac 3060
catcagctcc ctgcaaccag aggacattgc cacctactac tgccagaatg tgcacagctt 3120
cccattcacc tttggacagg gcactaaggt ggaaatcaag aggactgtgg ctgctccttc 3180
tgtgttcatc ttcccaccat cagatgaaca gctgaagagt ggcacagcct ctgttgtgtg 3240
cctgctcaac aacttctacc ctagagaagc caaggtgcag tggaaagtgg acaatgccct 3300
ccagtctggc aacagccaag aatctgtgac tgagcaggac tccaaggaca gcacatacag 3360
cctgagcagc acactgaccc tgagcaaggc tgactatgag aagcacaaag tctatgcctg 3420
tgaagtgaca caccagggcc tgtctagccc agtgaccaag tccttcaaca ggggagagag 3480
ctgaagatct acttctggct aataaaagat cagagctcta gtgatctgtg tgttggtttt 3540
ttgtgtctgc attctagcag gagtcaatgg gaaaaaccca ttggagccaa gtacactgac 3600
tcaataggga ctttccattg ggttttgccc agtacataag gtcaataggg ggtgagtcaa 3660
caggaaagtc ccattggagc caagtacatt gagtcaatag ggactttcca atgggttttg 3720
cccagtacat aaggtcaatg ggaggtaagc caatgggttt ttcccattac tgacatgtat 3780
actgagtcat tagggacttt ccaatgggtt ttgcccagta cataaggtca ataggggtga 3840
atcaacagga aagtcccatt ggagccaagt acactgagtc aatagggact ttccattggg 3900
ttttgcccag tacaaaaggt caataggggg tgagtcaatg ggtttttccc attattggca 3960
catacataag gtcaataggg gtgactagtg gagaagagca tgcttgaggg ctgagtgccc 4020
ctcagtgggc agagagcaca tggcccacag tccctgagaa gttgggggga ggggtgggca 4080
attgaactgg tgcctagaga aggtggggct tgggtaaact gggaaagtga tgtggtgtac 4140
tggctccacc tttttcccca gggtggggga gaaccatata taagtgcagt agtctctgtg 4200
aacattcaag cttctgcctt ctccctcctg tgagtttggt aagtcactga ctgtctatgc 4260
ctgggaaagg gtgggcagga gatggggcag tgcaggaaaa gtggcactat gaaccctgca 4320
gccctagaca attgtactaa ccttcttctc tttcctctcc tgacaggttg gtaaccaagc 4380
caccatggtc ctccagacac aggtgttcat cagcctgctg ctgtggatca gtggtgccta 4440
tggacaggtc cagctgcaag agtctggccc tggacttgtc agacccagcc agacactgag 4500
cctgacctgt acagtctctg gcttcagcct gaccagctac tctgtgcact gggtcagaca 4560
gcctccaggc agaggactgg aatggctggg agtgatctgg gccagtggtg gcacagacta 4620
caactctgcc ctgatgagca gactgagcat cctgaaggac aacagcaaga accaggtgtc 4680
cctgagactg tcctctgtga cagctgctga tacagctgtg tacttctgtg ccagagatcc 4740
tcctagctct ctgctgagac tggactactg gggccagggc acaacagtga cagtgtccag 4800
tgccagcaca aagggcccct ctgtgtttcc tctggctccc agcagcaaga gcaccagtgg 4860
tggaactgct gccctgggct gtctggtcaa ggactacttt cctgagcctg tgactgtgtc 4920
ctggaactct ggggctctga catctggggt gcacacattc cctgctgtgc tgcaatcctc 4980
tggcctgtac agcctcagct ctgtggtcac agtgcctagc tctagcctgg gcacccagac 5040
ctacatctgc aatgtgaacc acaagcctag caacaccaag gtggacaaga aggctgagcc 5100
caagagctgt gacaagaccc acacctgtcc tccatgtcct gctccagagc tgcttggagg 5160
acccagtgtg ttcctgtttc ctccaaagcc aaaggacacc ctgatgatca gcagaacccc 5220
tgaagtgacc tgtgtggtgg tggatgtgtc ccatgaggac cctgaagtca agttcaattg 5280
gtatgtggat ggtgttgagg tgcacaatgc caagaccaag cctagagagg aacagtacaa 5340
cagcacctac agagtggtgt cagtgctgac agtgctgcac caggactggc tgaatggcaa 5400
agagtacaag tgcaaggtgt ccaacaaggc cctgcctgct cctattgaaa agaccatcag 5460
caaggccaag ggccagccta gggaacccca ggtttacaca ctgccaccta gcagagatga 5520
gctgaccaaa aatcaggttt ccctgacctg cctggttaag ggcttctacc cctctgacat 5580
tgctgtggaa tgggagagca atggccagcc tgagaacaac tacaagacaa cccctcctgt 5640
gctggactct gatggctcat tcttcctgta ctccaagctg actgtggaca aaagcagatg 5700
gcagcaaggc aatgtgttca gctgctctgt gatgcatgag gccctgcaca accactacac 5760
ccagaagtcc ctgtctctga gccctggcaa gagaaagaga aggagtggct ctggggccac 5820
caactttagc ctgctgaaac aggctgggga tgttgaagag aaccctggac ctatggtgct 5880
gcaaacccag gttttcattt ctctgctcct ctggattagt ggtgcttatg gggacattgt 5940
gatgacacag agccctagca gcctgtctgc ctctgtggga gacagagtga ccatcacatg 6000
caagtccagc cagagtctgc tgaactctgg caaccagaag aactacctgg cctggtatca 6060
gcaaaagcct ggcaaggccc ctaagctgct catctatggg gccagcacca gagagtctgg 6120
ggtcccagat agattctctg gctctggatc tggcactgac ttcaccttca ccatcagctc 6180
cctgcaacca gaggacattg ccacctacta ctgccagaat gtgcacagct tcccattcac 6240
ctttggacag ggcactaagg tggaaatcaa gaggactgtg gctgctcctt ctgtgttcat 6300
cttcccacca tcagatgaac agctgaagag tggcacagcc tctgttgtgt gcctgctcaa 6360
caacttctac cctagagaag ccaaggtgca gtggaaagtg gacaatgccc tccagtctgg 6420
caacagccaa gaatctgtga ctgagcagga ctccaaggac agcacataca gcctgagcag 6480
cacactgacc ctgagcaagg ctgactatga gaagcacaaa gtctatgcct gtgaagtgac 6540
acaccagggc ctgtctagcc cagtgaccaa gtccttcaac aggggagaga gctgaagatc 6600
tacttctggc taataaaaga tcagagctct agtgatctgt gtgttggttt tttgtgtctg 6660
cattctagca gtcaatatgt tcaccccaaa aaagctgttt gttaacttgt caacctcatt 6720
ctaaaatgta tatagaagcc caaaagacaa taacaaaaat attcttgtag aacaaaatgg 6780
gaaagaatgt tccactaaat atcaagattt agagcaaagc atgagatgtg tggggataga 6840
cagtgaggct gataaaatag agtagagctc agaaacagac ccattgatat atgtaagtga 6900
cctatgaaaa aaatatggca ttttacaatg ggaaaatgat ggtctttttc ttttttagaa 6960
aaacagggaa atatatttat atgtaaaaaa taaaagggaa cccatatgtc ataccataca 7020
cacaaaaaaa ttccagtgaa ttataagtct aaatggagaa ggcaaaactt taaatctttt 7080
agaaaataat atagaagcat gccatcaaga cttcagtgta gagaaaaatt tcttatgact 7140
caaagtccta accacaaaga aaagattgtt aattagattg catgaatatt aagacttatt 7200
tttaaaatta aaaaaccatt aagaaaagtc aggccataga atgacagaaa atatttgcaa 7260
caccccagta aagagaattg taatatgcag attataaaaa gaagtcttac aaatcagtaa 7320
aaaataaaac tagacaaaaa tttgaacaga tgaaagagaa actctaaata atcattacac 7380
atgagaaact caatctcaga aatcagagaa ctatcattgc atatacacta aattagagaa 7440
atattaaaag gctaagtaac atctgtggct taattaatct agctctagtg atcagcagtt 7500
caacctgttg atagtatgta ctaagctctc atgtttaatg tactaagctc tcatgtttaa 7560
tgaactaaac cctcatggct aatgtactaa gctctcatgg ctaatgtact aagctctcat 7620
gtttcatgta ctaagctctc atgtttgaac aataaaatta atataaatca gcaacttaaa 7680
tagcctctaa ggttttaagt tttataagaa aaaaaagaat atataaggct tttaaaggtt 7740
ttaaggtttc ctaggttatc ctcatatgag ctcttagaaa aactcatcca gcatcaaatg 7800
aaactgcaat ttattcatat caggattatc aataccatat ttttgaaaaa gtcttttctg 7860
taatgaagga gaaaactcac ccaggcagtt ccataggatg gcaagatcct ggtatctgtc 7920
tgcaattcca actcttccaa catcaataca acctattaat ttcccctcat caaaaataag 7980
gttatcaagt gagaaatcac catgagtgac cactgaatct ggtgagaatg gcaaaagatt 8040
atgcatttct ttccagactt gttcaacagg ccagccattt ctctcatcat caaaatcact 8100
ggcatcaacc aaaccattat tcattcttga ttgggcctga gccagtctaa atactctatc 8160
agagttaaaa ggacaattac aaacaggaat ggaatgcaat cttctcagga acactgccag 8220
ggcatcaaca atattttcac ctgaatcagg atattcttcc aatacctgga atgctgtttt 8280
ccctgggatg gcagtggtga gtaaccatgc atcatcagga gttctgataa aatgcttgat 8340
ggttggaaga ggcataaatt cagtcagcca gtttagtctg accatctcat ctgtaacatc 8400
attggcaaca gaacctttgc catgtttcag aaacaactct ggggcatctg gcttcccata 8460
caatctatag attgtggcac ctgattgccc aacattatct ctagcccatt tatacccata 8520
taaatcagca tccatgttgg aatttaatct tggcctggag caagaggttt ctctttgaat 8580
atggctcata catgtgcacc tcctatagtg agttgtatta tactatgcag atatactatg 8640
ccaatgttta attgtcag 8658
<210> 38
<211> 8646
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic
<400> 38
cactatgtgt taattaaaat tatctctaag gcatgtgaac tggctgtctt ggttttcatc 60
tgtacttcat ctgctacctc tgtgacctga aacatattta taattccatt aagctgtgca 120
tatgatagat ttatcatatg tattttcctt aaaggatttt tgtaagaact aattgaattg 180
atacctgtaa agtctttatc acactaccca ataaataata aatctctttg ttcagctctc 240
tgtttctata aatatgtacc agttttattg tttttagtgg tagtgatttt attctctttc 300
tatatatata cacacacatg tgtgcattca taaatatata caatttttat gaataaaaaa 360
ttattagcaa tcaatattga aaaccactga tttttgttta tgtgagcaaa cagcagatta 420
aaaggaattt gaattctcat agctagcagg agtcaatggg aaaaacccat tggagccaag 480
tacactgact caatagggac tttccattgg gttttgccca gtacataagg tcaatagggg 540
gtgagtcaac aggaaagtcc cattggagcc aagtacattg agtcaatagg gactttccaa 600
tgggttttgc ccagtacata aggtcaatgg gaggtaagcc aatgggtttt tcccattact 660
gacatgtata ctgagtcatt agggactttc caatgggttt tgcccagtac ataaggtcaa 720
taggggtgaa tcaacaggaa agtcccattg gagccaagta cactgagtca atagggactt 780
tccattgggt tttgcccagt acaaaaggtc aatagggggt gagtcaatgg gtttttccca 840
ttattggcac atacataagg tcaatagggg tgactagtgg agaagagcat gcttgagggc 900
tgagtgcccc tcagtgggca gagagcacat ggcccacagt ccctgagaag ttggggggag 960
gggtgggcaa ttgaactggt gcctagagaa ggtggggctt gggtaaactg ggaaagtgat 1020
gtggtgtact ggctccacct ttttccccag ggtgggggag aaccatatat aagtgcagta 1080
gtctctgtga acattcaagc ttctgccttc tccctcctgt gagtttggta agtcactgac 1140
tgtctatgcc tgggaaaggg tgggcaggag atggggcagt gcaggaaaag tggcactatg 1200
aaccctgcag ccctagacaa ttgtactaac cttcttctct ttcctctcct gacaggttgg 1260
taaccaagcc accatgggat ggtccctgat cctgctgttt ctggtggctg tggccaccag 1320
agtgctgtct gaagtgcagc tggtggaatc tggccctggc ctggttaagc cctctgacat 1380
cctgagcctg acctgtgctg tgtctggcta cagcatcagc agcaactact actggggctg 1440
gatcagacag cctcctggca aaggcctgga atggattggc agcatctacc actctggctc 1500
cacctactac aagcccagcc tggaaagcag actgggcatc tctgtggaca ccagcaagaa 1560
ccagttcagc ctgaagctga gctttgtgtc tgctgctgac actgctgtgt actactgtgc 1620
cagacatgtt aggagtggct accctgacac agcctactac tttgataagt ggggccaggg 1680
caccctggtc acagtgtctg cttctacaaa gggcccctct gtgttcccac tggctcctag 1740
cagcaagagc accagtggtg gaacagctgc cctgggctgt ctggtcaagg actactttcc 1800
tgagccagtg acagtgtcct ggaactctgg ggctctgact tctggggtgc acacattccc 1860
tgctgtgctc cagtcctctg gcctgtacag cctgtcctct gtggtcactg tgccaagctc 1920
tagcctgggc acccagacct acatctgcaa tgtgaaccac aagcctagca acaccaaggt 1980
ggacaagaag gctgagccca agagctgtga caagacccac acctgtcctc catgtcctgc 2040
tccagagctg cttggaggac cttctgtgtt tctgttccct ccaaagccaa aggacaccct 2100
gatgatcagc agaacccctg aagtgacctg tgtggtggtg gatgtgtccc atgaggaccc 2160
agaagtgaag ttcaattggt atgtggatgg tgttgaggtg cacaatgcca agaccaagcc 2220
tagagaggaa cagtacaaca gcacctacag ggttgtgtca gtgctgactg tgctgcacca 2280
ggactggctg aatggcaaag agtacaagtg caaggtgtcc aacaaggccc tgcctgctcc 2340
tattgaaaag accatcagca aggccaaggg acagcctagg gaaccccagg tgtacacact 2400
gccacctagc agagatgagc tgaccaagaa tcaggtgtcc ctgacatgcc ttgtgaaggg 2460
cttctaccct tctgacattg cagtggaatg ggagagcaat ggccagcctg agaacaacta 2520
caagacaacc cctcctgtgc tggactctga tggctcattc ttcctgtact ccaagctgac 2580
agtggacaag tccagatggc agcaaggcaa tgtgttcagc tgctctgtga tgcatgaggc 2640
cctgcacaac cactacacac agaagtccct gtctctgagc cctggcaaga gaaagagaag 2700
gagtggatct ggggccacca acttcagcct gctgaaacag gctggggatg ttgaagagaa 2760
ccctggacct atggcctggg ctctgctgct tctgggactg ctgtctcact gcacaggcag 2820
tgtgaccagc tatgtgctga cccagcctcc atctgtgtct gtggctccag gggagacagc 2880
cagaatcagc tgtggtggca acaacattgg cacaaaggtg ctgcactggt atcagcagac 2940
tccaggacag gcaccagtgc tggtggtgta tgatgactct gacagaccct ctggcatccc 3000
agagaggttc tctggcagca actctggcaa cacagccaca ctgaccatct ccagagtgga 3060
agttggagat gaggctgatt actactgcca agtgtgggac atcagcacag accaggctgt 3120
gtttggtggt ggcaccaagc tcactgtgct gggccaacct aaagctgccc cttctgtgac 3180
actgttccca cctagctctg aggaactcca ggctaacaag gccacacttg tgtgcctgat 3240
cagtgacttc tacccagggg ctgtgactgt ggcctggaag gctgatagca gccctgtgaa 3300
ggctggggtt gagacaacca cacctagcaa gcagagcaac aacaaatatg ctgccagcag 3360
ctacctgagt ctgacccctg agcagtggaa gtcccacaga tcctacagct gtcaagtgac 3420
ccatgagggc tccacagtgg aaaagacagt ggcccctaca gagtgctcct gaagatctac 3480
ttctggctaa taaaagatca gagctctagt gatctgtgtg ttggtttttt gtgtctgcat 3540
tctagcagga gtcaatggga aaaacccatt ggagccaagt acactgactc aatagggact 3600
ttccattggg ttttgcccag tacataaggt caataggggg tgagtcaaca ggaaagtccc 3660
attggagcca agtacattga gtcaataggg actttccaat gggttttgcc cagtacataa 3720
ggtcaatggg aggtaagcca atgggttttt cccattactg acatgtatac tgagtcatta 3780
gggactttcc aatgggtttt gcccagtaca taaggtcaat aggggtgaat caacaggaaa 3840
gtcccattgg agccaagtac actgagtcaa tagggacttt ccattgggtt ttgcccagta 3900
caaaaggtca atagggggtg agtcaatggg tttttcccat tattggcaca tacataaggt 3960
caataggggt gactagtgga gaagagcatg cttgagggct gagtgcccct cagtgggcag 4020
agagcacatg gcccacagtc cctgagaagt tggggggagg ggtgggcaat tgaactggtg 4080
cctagagaag gtggggcttg ggtaaactgg gaaagtgatg tggtgtactg gctccacctt 4140
tttccccagg gtgggggaga accatatata agtgcagtag tctctgtgaa cattcaagct 4200
tctgccttct ccctcctgtg agtttggtaa gtcactgact gtctatgcct gggaaagggt 4260
gggcaggaga tggggcagtg caggaaaagt ggcactatga accctgcagc cctagacaat 4320
tgtactaacc ttcttctctt tcctctcctg acaggttggt aaccaagcca ccatggtcct 4380
ccagacacag gtgttcatca gcctgctgct gtggatcagt ggtgcctatg gacaggtcca 4440
gctgcaagag tctggccctg gacttgtcag acccagccag acactgagcc tgacctgtac 4500
agtctctggc ttcagcctga ccagctactc tgtgcactgg gtcagacagc ctccaggcag 4560
aggactggaa tggctgggag tgatctgggc cagtggtggc acagactaca actctgccct 4620
gatgagcaga ctgagcatcc tgaaggacaa cagcaagaac caggtgtccc tgagactgtc 4680
ctctgtgaca gctgctgata cagctgtgta cttctgtgcc agagatcctc ctagctctct 4740
gctgagactg gactactggg gccagggcac aacagtgaca gtgtccagtg ccagcacaaa 4800
gggcccctct gtgtttcctc tggctcccag cagcaagagc accagtggtg gaactgctgc 4860
cctgggctgt ctggtcaagg actactttcc tgagcctgtg actgtgtcct ggaactctgg 4920
ggctctgaca tctggggtgc acacattccc tgctgtgctg caatcctctg gcctgtacag 4980
cctcagctct gtggtcacag tgcctagctc tagcctgggc acccagacct acatctgcaa 5040
tgtgaaccac aagcctagca acaccaaggt ggacaagaag gctgagccca agagctgtga 5100
caagacccac acctgtcctc catgtcctgc tccagagctg cttggaggac ccagtgtgtt 5160
cctgtttcct ccaaagccaa aggacaccct gatgatcagc agaacccctg aagtgacctg 5220
tgtggtggtg gatgtgtccc atgaggaccc tgaagtcaag ttcaattggt atgtggatgg 5280
tgttgaggtg cacaatgcca agaccaagcc tagagaggaa cagtacaaca gcacctacag 5340
agtggtgtca gtgctgacag tgctgcacca ggactggctg aatggcaaag agtacaagtg 5400
caaggtgtcc aacaaggccc tgcctgctcc tattgaaaag accatcagca aggccaaggg 5460
ccagcctagg gaaccccagg tttacacact gccacctagc agagatgagc tgaccaaaaa 5520
tcaggtttcc ctgacctgcc tggttaaggg cttctacccc tctgacattg ctgtggaatg 5580
ggagagcaat ggccagcctg agaacaacta caagacaacc cctcctgtgc tggactctga 5640
tggctcattc ttcctgtact ccaagctgac tgtggacaaa agcagatggc agcaaggcaa 5700
tgtgttcagc tgctctgtga tgcatgaggc cctgcacaac cactacaccc agaagtccct 5760
gtctctgagc cctggcaaga gaaagagaag gagtggctct ggggccacca actttagcct 5820
gctgaaacag gctggggatg ttgaagagaa ccctggacct atggtgctgc aaacccaggt 5880
tttcatttct ctgctcctct ggattagtgg tgcttatggg gacattgtga tgacacagag 5940
ccctagcagc ctgtctgcct ctgtgggaga cagagtgacc atcacatgca agtccagcca 6000
gagtctgctg aactctggca accagaagaa ctacctggcc tggtatcagc aaaagcctgg 6060
caaggcccct aagctgctca tctatggggc cagcaccaga gagtctgggg tcccagatag 6120
attctctggc tctggatctg gcactgactt caccttcacc atcagctccc tgcaaccaga 6180
ggacattgcc acctactact gccagaatgt gcacagcttc ccattcacct ttggacaggg 6240
cactaaggtg gaaatcaaga ggactgtggc tgctccttct gtgttcatct tcccaccatc 6300
agatgaacag ctgaagagtg gcacagcctc tgttgtgtgc ctgctcaaca acttctaccc 6360
tagagaagcc aaggtgcagt ggaaagtgga caatgccctc cagtctggca acagccaaga 6420
atctgtgact gagcaggact ccaaggacag cacatacagc ctgagcagca cactgaccct 6480
gagcaaggct gactatgaga agcacaaagt ctatgcctgt gaagtgacac accagggcct 6540
gtctagccca gtgaccaagt ccttcaacag gggagagagc tgaagatcta cttctggcta 6600
ataaaagatc agagctctag tgatctgtgt gttggttttt tgtgtctgca ttctagcagt 6660
caatatgttc accccaaaaa agctgtttgt taacttgtca acctcattct aaaatgtata 6720
tagaagccca aaagacaata acaaaaatat tcttgtagaa caaaatggga aagaatgttc 6780
cactaaatat caagatttag agcaaagcat gagatgtgtg gggatagaca gtgaggctga 6840
taaaatagag tagagctcag aaacagaccc attgatatat gtaagtgacc tatgaaaaaa 6900
atatggcatt ttacaatggg aaaatgatgg tctttttctt ttttagaaaa acagggaaat 6960
atatttatat gtaaaaaata aaagggaacc catatgtcat accatacaca caaaaaaatt 7020
ccagtgaatt ataagtctaa atggagaagg caaaacttta aatcttttag aaaataatat 7080
agaagcatgc catcaagact tcagtgtaga gaaaaatttc ttatgactca aagtcctaac 7140
cacaaagaaa agattgttaa ttagattgca tgaatattaa gacttatttt taaaattaaa 7200
aaaccattaa gaaaagtcag gccatagaat gacagaaaat atttgcaaca ccccagtaaa 7260
gagaattgta atatgcagat tataaaaaga agtcttacaa atcagtaaaa aataaaacta 7320
gacaaaaatt tgaacagatg aaagagaaac tctaaataat cattacacat gagaaactca 7380
atctcagaaa tcagagaact atcattgcat atacactaaa ttagagaaat attaaaaggc 7440
taagtaacat ctgtggctta attaatctag ctctagtgat cagcagttca acctgttgat 7500
agtatgtact aagctctcat gtttaatgta ctaagctctc atgtttaatg aactaaaccc 7560
tcatggctaa tgtactaagc tctcatggct aatgtactaa gctctcatgt ttcatgtact 7620
aagctctcat gtttgaacaa taaaattaat ataaatcagc aacttaaata gcctctaagg 7680
ttttaagttt tataagaaaa aaaagaatat ataaggcttt taaaggtttt aaggtttcct 7740
aggttatcct catatgagct cttagaaaaa ctcatccagc atcaaatgaa actgcaattt 7800
attcatatca ggattatcaa taccatattt ttgaaaaagt cttttctgta atgaaggaga 7860
aaactcaccc aggcagttcc ataggatggc aagatcctgg tatctgtctg caattccaac 7920
tcttccaaca tcaatacaac ctattaattt cccctcatca aaaataaggt tatcaagtga 7980
gaaatcacca tgagtgacca ctgaatctgg tgagaatggc aaaagattat gcatttcttt 8040
ccagacttgt tcaacaggcc agccatttct ctcatcatca aaatcactgg catcaaccaa 8100
accattattc attcttgatt gggcctgagc cagtctaaat actctatcag agttaaaagg 8160
acaattacaa acaggaatgg aatgcaatct tctcaggaac actgccaggg catcaacaat 8220
attttcacct gaatcaggat attcttccaa tacctggaat gctgttttcc ctgggatggc 8280
agtggtgagt aaccatgcat catcaggagt tctgataaaa tgcttgatgg ttggaagagg 8340
cataaattca gtcagccagt ttagtctgac catctcatct gtaacatcat tggcaacaga 8400
acctttgcca tgtttcagaa acaactctgg ggcatctggc ttcccataca atctatagat 8460
tgtggcacct gattgcccaa cattatctct agcccattta tacccatata aatcagcatc 8520
catgttggaa tttaatcttg gcctggagca agaggtttct ctttgaatat ggctcataca 8580
tgtgcacctc ctatagtgag ttgtattata ctatgcagat atactatgcc aatgtttaat 8640
tgtcag 8646
<210> 39
<211> 654
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic
<400> 39
atggctacag gcagcagaac ctctctgctg ctggcttttg gcctgctgtg tctgccttgg 60
ctgcaagagg gctctgcttt ccctacaatc cctctgagca ggctgtttga caatgccatg 120
ctgagagccc acagactgca ccagctggcc tttgacacct accaagagtt tgaagaggct 180
tacatcccca aagagcagaa gtacagcttc ctccagaatc ctcagaccag cctgtgcttc 240
tctgagagca tccccacacc tagcaacaga gaggaaaccc agcagaagtc caacctggaa 300
ctgctgagaa tcagcctgct gctgatccag agctggctgg aacctgtgca gttcctgaga 360
tcagtgtttg ccaacagcct ggtgtatggg gcctctgaca gcaatgtgta tgacctgctg 420
aaggacctgg aagagggcat ccagacactg atgggcagac tggaagatgg cagccccaga 480
acaggccaga ttttcaagca gacctacagc aagtttgaca ccaacagcca caatgatgat 540
gccctgctca agaactatgg gctgctgtac tgcttcagaa aggacatgga caaggtggaa 600
accttcctga ggattgtgca gtgcagaagt gtggaaggca gctgtggctt ctga 654
<210> 40
<211> 1350
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic
<400> 40
atggctacag gcagcagaac ctctctgctg ctggcttttg gcctgctgtg tctgccttgg 60
ctgcaagagg gctctgcttt ccctacaatc cctctgagca ggctgtttga caatgccatg 120
ctgagagccc acagactgca ccagctggcc tttgacacct accaagagtt tgaagaggct 180
tacatcccca aagagcagaa gtacagcttc ctccagaatc ctcagaccag cctgtgcttc 240
tctgagagca tccccacacc tagcaacaga gaggaaaccc agcagaagtc caacctggaa 300
ctgctgagaa tcagcctgct gctgatccag agctggctgg aacctgtgca gttcctgaga 360
tcagtgtttg ccaacagcct ggtgtatggg gcctctgaca gcaatgtgta tgacctgctg 420
aaggacctgg aagagggcat ccagacactg atgggcagac tggaagatgg cagccccaga 480
acaggccaga ttttcaagca gacctacagc aagtttgaca ccaacagcca caatgatgat 540
gccctgctca agaactatgg gctgctgtac tgcttcagaa aggacatgga caaggtggaa 600
accttcctga ggattgtgca gtgcagaagt gtggaaggca gctgtggctt tgagcccaag 660
agctgtgaca agacccacac ctgtcctcca tgtcctgctc cagagctgct tggaggacct 720
tctgtgtttc tgttccctcc aaagccaaag gacaccctga tgatcagcag aacccctgaa 780
gtgacctgtg tggtggtgga tgtgtcccat gaggacccag aagtgaagtt caattggtat 840
gtggatggtg ttgaggtgca caatgccaag accaagccta gagaggaaca gtacaacagc 900
acctacaggg ttgtgtcagt gctgactgtg ctgcaccagg actggctgaa tggcaaagag 960
tacaagtgca aggtgtccaa caaggccctg cctgctccta ttgaaaagac catcagcaag 1020
gccaagggac agcctaggga accccaggtg tacacactgc cacctagcag agatgagctg 1080
accaagaatc aggtgtccct gacatgcctt gtgaagggct tctacccttc tgacattgca 1140
gtggaatggg agagcaatgg ccagcctgag aacaactaca agacaacccc tcctgtgctg 1200
gactctgatg gctcattctt cctgtactcc aagctgacag tggacaagtc cagatggcag 1260
caaggcaatg tgttcagctg ctctgtgatg catgaggccc tgcacaacca ctacacacag 1320
aagtccctgt ctctgagccc tggcaagtga 1350
<210> 41
<211> 5
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic
<400> 41
ggggs 5
<210> 42
<211> 15
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic
<400> 42
ggtggaggag gtagt 15
<210> 43
<211> 30
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic
<400> 43
ggtggaggag gtagtggggg tggaggttca 30
<210> 44
<211> 45
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic
<400> 44
ggaggaggtg gatcaggtgg aggaggtagt gggggtggag gttca 45
<210> 45
<211> 699
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic
<400> 45
gagcccaaga gctgtgacaa gacccacacc tgtcctccat gtcctgctcc agagctgctt 60
ggaggacctt ctgtgtttct gttccctcca aagccaaagg acaccctgat gatcagcaga 120
acccctgaag tgacctgtgt ggtggtggat gtgtcccatg aggacccaga agtgaagttc 180
aattggtatg tggatggtgt tgaggtgcac aatgccaaga ccaagcctag agaggaacag 240
tacaacagca cctacagggt tgtgtcagtg ctgactgtgc tgcaccagga ctggctgaat 300
ggcaaagagt acaagtgcaa ggtgtccaac aaggccctgc ctgctcctat tgaaaagacc 360
atcagcaagg ccaagggaca gcctagggaa ccccaggtgt acacactgcc acctagcaga 420
gatgagctga ccaagaatca ggtgtccctg acatgccttg tgaagggctt ctacccttct 480
gacattgcag tggaatggga gagcaatggc cagcctgaga acaactacaa gacaacccct 540
cctgtgctgg actctgatgg ctcattcttc ctgtactcca agctgacagt ggacaagtcc 600
agatggcagc aaggcaatgt gttcagctgc tctgtgatgc atgaggccct gcacaaccac 660
tacacacaga agtccctgtc tctgagccct ggcaagtga 699
<210> 46
<211> 699
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic
<400> 46
gagcccaaga gctgtgacaa gacccacacc tgtcctccat gtcctgctcc agagctgctt 60
ggaggacctt ctgtgtttct gttccctcca aagccaaagg acaccctgat gatcagcaga 120
acccctgaag tgacctgtgt ggtggtggat gtgtcccatg aggacccaga agtgaagttc 180
aattggtatg tggatggtgt tgaggtgcac aatgccaaga ccaagcctag agaggaacag 240
tacaacagca cctacagggt tgtgtcagtg ctgactgtgc tgcaccagga ctggctgaat 300
ggcaaagagt acaagtgcaa ggtgtccaac aaggccctgc ctgctcctat tgaaaagacc 360
atcagcaagg ccaagggaca gcctagggaa ccccaggtgt acacactgcc accttgcaga 420
gatgagctga ccaagaatca ggtgtccctg tggtgccttg tgaagggctt ctacccttct 480
gacattgcag tggaatggga gagcaatggc cagcctgaga acaactacaa gacaacccct 540
cctgtgctgg actctgatgg ctcattcttc ctgtactcca agctgacagt ggacaagtcc 600
agatggcagc aaggcaatgt gttcagctgc tctgtgatgc atgaggccct gcacaaccac 660
tacacacaga agtccctgtc tctgagccct ggcaagtga 699
<210> 47
<211> 699
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic
<400> 47
gagcccaaga gctgtgacaa gacccacacc tgtcctccat gtcctgctcc agagctgctt 60
ggaggacctt ctgtgtttct gttccctcca aagccaaagg acaccctgat gatcagcaga 120
acccctgaag tgacctgtgt ggtggtggat gtgtcccatg aggacccaga agtgaagttc 180
aattggtatg tggatggtgt tgaggtgcac aatgccaaga ccaagcctag agaggaacag 240
tacaacagca cctacagggt tgtgtcagtg ctgactgtgc tgcaccagga ctggctgaat 300
ggcaaagagt acaagtgcaa ggtgtccaac aaggccctgc ctgctcctat tgaaaagacc 360
atcagcaagg ccaagggaca gcctagggaa ccccaggtgt gcacactgcc acctagcaga 420
gatgagctga ccaagaatca ggtgtccctg tcatgtgctg tgaagggctt ctacccttct 480
gacattgcag tggaatggga gagcaatggc cagcctgaga acaactacaa gacaacccct 540
cctgtgctgg actctgatgg ctcattcttc ctggtctcca agctgacagt ggacaagtcc 600
agatggcagc aaggcaatgt gttcagctgc tctgtgatgc atgaggccct gcacaaccac 660
tacacacaga agtccctgtc tctgagccct ggcaagtga 699
<210> 48
<211> 699
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic
<400> 48
gagcccaaga gctgtgacaa gacccacacc tgtcctccat gtcctgctcc agagctgctt 60
ggaggacctt ctgtgtttct gttccctcca aagccaaagg acaccctgat gatcagcaga 120
acccctgaag tgacctgtgt ggtggtggat gtgtcccatg aggacccaga agtgaagttc 180
aattggtatg tggatggtgt tgaggtgcac aatgccaaga ccaagcctag agaggaacag 240
tacaacagca cctacagggt tgtgtcagtg ctgactgtgc tgcaccagga ctggctgaat 300
ggcaaagagt acaagtgcaa ggtgtccaac aaggccctgc ctgctcctat tgaaaagacc 360
atcagcaagg ccaagggaca gcctagggaa ccccaggtgt gcacactgcc accttgcaga 420
gatgagctga ccaagaatca ggtgtccctg tcatgtgctg tgaagggctt ctacccttct 480
gacattgcag tggaatggga gagcaatggc cagcctgaga acaactacaa gacaacccct 540
cctgtgctgg actctgatgg ctcattcttc ctggtctcca agctgacagt ggacaagtcc 600
agatggcagc aaggcaatgt gttcagctgc tctgtgatgc atgaggccct gcacaaccac 660
tacacacaga agtccctgtc tctgagccct ggcaagtga 699
<210> 49
<211> 684
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic
<400> 49
gaaagcaaat atggcccacc atgtcctcca tgtccagctc cagaatttct tggtggccca 60
agtgtctttc tgtttccacc taaacctaaa gacacactca tgatctctag gacacctgaa 120
gtcacatgtg ttgttgttga tgtttctcaa gaagatcctg aagtccagtt taattggtat 180
gttgatgggg ttgaagtcca taatgctaag acaaagccca gggaagaaca gtataactcc 240
acatacaggg ttgtgtctgt cctcactgtt ctgcatcagg attggctcaa tgggaaagaa 300
tacaaatgta aagtctcaaa caaggggctc cccagctcca ttgagaaaac catctctaag 360
gctaaaggcc aacctaggga acctcaagtg tataccctgc cacctagcca gaaagaaatg 420
acaaagaatc aagtctccct cacctgtctt gtcaaaggct tttatcctag tgacattgca 480
gttgagtggg aatccaatgg gcagccagaa aacaattata agacaacccc accagttctt 540
gatagtgatg gctcattttt tctctactct aaactgacag ttgataagag taggtggcaa 600
gagggaaatg tcttttcttg ttctgttatg catgaagctc tccacaatag gtacacccag 660
aagtctctgt ccctgtctcc ttga 684
<210> 50
<211> 738
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic
<400> 50
agaaacacag gcagaggtgg agaggaaaag aagaaagaga aagaaaaaga ggaacaagag 60
gaaagggaaa ctaagacccc tgagtgcccc agccacacac agcctctggg agtgttcctg 120
tttcctccaa agccaaagga caccctgatg atcagcagaa cccctgaagt gacctgtgtg 180
gtggtggatg tgtcccaaga ggacccagag gtgcagttca attggtatgt ggatggtgtt 240
gaggtgcaca atgccaagac caagcctaga gaggaacagt tcaacagcac ctacagagtg 300
gtgtctgtgc tgacagtgct gcaccaggac tggctgaatg gcaaagagta caagtgcaag 360
gtgtccaaca agggcctgcc tagcagcatt gaaaagacca tcagcaaggc caagggccag 420
ccaagagaac cccaggtgta cacactgcct ccaagccaag aagagatgac caagaaccag 480
gtgtccctga cctgcctggt caagggcttc tacccctctg acattgctgt ggaatgggag 540
agcaatggcc agcctgagaa caactacaag accacacctc ctgtgctgga ctctgatggc 600
tcattcttcc tgtacagcag actgacagtg gacaagagca gatggcaaga gggcaatgtg 660
ttcagctgct ctgtgatgca tgaggccctg cacaaccact acacccagaa gtctctgagc 720
ctgagcctgg gcaaatga 738
<210> 51
<211> 699
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic
<400> 51
cctagaggcc ccaccatcaa gccctgtcct ccatgcaaat gccctgctcc taacctgctt 60
ggaggcccct ctgtgttcat cttcccacct aagatcaagg atgtgctgat gatctctctg 120
agccccattg tgacctgtgt ggtggtggat gtgtctgagg atgacccaga tgtgcagatt 180
tcttggtttg tgaacaatgt ggaagtgcac acagcccaga ctcagaccca cagagaggac 240
tacaacagca cactgagagt ggtgtctgcc ctgcctatcc agcaccagga ttggatgtct 300
ggcaaagagt tcaagtgcaa agtgaacaac aaggacctgc ctgctccaat tgagaggacc 360
atctccaagc caaagggctc tgtcagggcc cctcaagtgt atgtgctgcc tcctccagag 420
gaagagatga ccaagaagca agtcaccctg acatgcatgg tcacagactt catgccagag 480
gacatctatg tggaatggac caacaatggc aagacagagc tgaactacaa gaacactgag 540
ccagtgctgg actctgatgg cagctacttc atgtacagca agctgagggt tgagaagaag 600
aactgggttg agagaaacag ctacagctgc tctgtggtgc atgagggcct gcacaatcac 660
cacaccacca agagcttcag cagaacccct ggcaagtga 699
<210> 52
<211> 699
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic
<400> 52
gagcccaaga gctgtgacaa gacccacacc tgtcctccat gtcctgctcc agagctgctt 60
gcaggacctt ctgtgtttct gttccctcca aagccaaagg acaccctgat gatcagcaga 120
acccctgaag tgacctgtgt ggtggtggat gtgtcccatg aggacccaga agtgaagttc 180
aattggtatg tggatggtgt tgaggtgcac aatgccaaga ccaagcctag agaggaacag 240
tacaacagca cctacagggt tgtgtcagtg ctgactgtgc tgcaccagga ctggctgaat 300
ggcaaagagt acaagtgcaa ggtgtccaac aaggccctgc ctcttcctga ggaaaagacc 360
atcagcaagg ccaagggaca gcctagggaa ccccaggtgt acacactgcc acctagcaga 420
gatgagctga ccaagaatca ggtgtccctg acatgccttg tgaagggctt ctacccttct 480
gacattgcag tggaatggga gagcaatggc cagcctgaga acaactacaa gacaacccct 540
cctgtgctgg actctgatgg ctcattcttc ctgtactcca agctgacagt ggacaagtcc 600
agatggcagc aaggcaatgt gttcagctgc tctgtgatgc atgaggccct gcacaaccac 660
tacacacaga agtccctgtc tctgagccct ggcaagtga 699
<210> 53
<211> 699
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic
<400> 53
gagcccaaga gctgtgacaa gacccacacc tgtcctccat gtcctgctcc agagctgctt 60
gcaggacctt ctgtgtttct gttccctcca aagccaaagg acaccctgat gatcagcaga 120
acccctgaag tgacctgtgt ggtggtggat gtgtcccatg aggacccaga agtgaagttc 180
aattggtatg tggatggtgt tgaggtgcac aatgccaaga ccaagcctag agaggaacag 240
tacaacagca cctacagggt tgtgtcagtg ctgactgtgc tgcaccagga ctggctgaat 300
ggcaaagagt acaagtgcaa ggtgtccaac aaggccctgc ctcttcctga ggaaaagacc 360
atcagcaagg ccaagggaca gcctagggaa ccccaggtgt acacactgcc acctagcaga 420
gatgagctga ccaagaatca ggtgtccctg acatgccttg tgaagggctt ctacccttct 480
gacattgcag tggaatggga gagcaatggc cagcctgaga acaactacaa gacaacccct 540
cctgtgctgg actctgatgg ctcattcttc ctgtactcca agctgacagt ggacaagtcc 600
agatggcagc aaggcaatgt gttcagctgc tctgtgttgc atgaggccct gcactctcac 660
tacacacaga agtccctgtc tctgagccct ggcaagtga 699
<210> 54
<211> 2424
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic
<400> 54
atggctacag gcagcagaac ctctctgctg ctggcttttg gcctgctgtg tctgccttgg 60
ctgcaagagg gctctgcttt ccctacaatc cctctgagca ggctgtttga caatgccatg 120
ctgagagccc acagactgca ccagctggcc tttgacacct accaagagtt tgaagaggct 180
tacatcccca aagagcagaa gtacagcttc ctccagaatc ctcagaccag cctgtgcttc 240
tctgagagca tccccacacc tagcaacaga gaggaaaccc agcagaagtc caacctggaa 300
ctgctgagaa tcagcctgct gctgatccag agctggctgg aacctgtgca gttcctgaga 360
tcagtgtttg ccaacagcct ggtgtatggg gcctctgaca gcaatgtgta tgacctgctg 420
aaggacctgg aagagggcat ccagacactg atgggcagac tggaagatgg cagccccaga 480
acaggccaga ttttcaagca gacctacagc aagtttgaca ccaacagcca caatgatgat 540
gccctgctca agaactatgg gctgctgtac tgcttcagaa aggacatgga caaggtggaa 600
accttcctga ggattgtgca gtgcagaagt gtggaaggca gctgtggctt tggtggagga 660
ggtagtgatg cccacaagtc tgaggtggcc cacagattca aggacctggg agaagagaac 720
ttcaaggccc tggtgctgat tgcctttgct cagtacctcc agcagtgccc ctttgaggac 780
catgtgaagc tggtcaatga agtgacagag tttgccaaga cctgtgtggc tgatgagtct 840
gctgagaact gtgacaagag cctgcacacc ctgtttggag acaagctgtg tacagtggcc 900
acactgagag aaacctatgg agagatggct gactgctgtg ccaagcaaga acctgagagg 960
aatgagtgct tcctccagca caaggatgac aaccccaacc tgcctagact tgtcagacct 1020
gaagtggatg tgatgtgcac agccttccat gacaatgagg aaaccttcct gaagaaatac 1080
ctgtatgaga ttgccagaag gcacccctac ttctatgccc ctgagctgct gttctttgct 1140
aagagataca aggctgcctt tacagagtgc tgccaggctg ctgacaaagc tgcctgtctg 1200
ctgcccaagc tggatgagct gagagatgaa ggcaaggcct cctctgccaa gcagagactg 1260
aagtgtgcca gcctccagaa gtttggagag agagccttca aggcttgggc tgttgccaga 1320
ctgagccaga gattccccaa ggctgagttt gctgaggtgt ccaagctggt tacagacctg 1380
accaaggtgc acactgaatg ctgccatggg gacctgctgg aatgtgctga tgacagagct 1440
gacctggcca agtacatctg tgaaaaccag gacagcatca gcagcaagct gaaagaatgc 1500
tgtgaaaagc ccctcctgga aaagagccac tgcattgcag aggtggaaaa tgatgagatg 1560
cctgctgatc tgcccagcct tgcagctgac tttgtggaaa gcaaggatgt gtgcaagaac 1620
tatgctgagg ccaaagatgt gttcctgggc atgttcctct atgagtatgc tagaaggcat 1680
cctgactact ctgtggtgct gctgctgaga ctggctaaga cctatgagac aacactggaa 1740
aagtgctgtg cagctgctga ccctcatgag tgctatgcca aagtgtttga tgagttcaag 1800
cctctggtgg aagaacccca gaacctgatc aagcagaatt gtgaactgtt tgagcagctg 1860
ggagagtaca agttccagaa tgccctgctt gtcagataca ccaagaaggt gccccaggtt 1920
tccacaccta cactggttga agtgtccaga aatctgggca aagtgggcag caagtgctgc 1980
aagcacccag aggccaagag gatgccatgt gctgaggact acctgtcagt ggtgctgaac 2040
cagctgtgtg tcctgcatga gaaaacccct gtgtctgaca gagtgacaaa gtgttgcaca 2100
gagagcctgg tcaacagaag gccttgcttc tctgccctgg aagttgatga gacatatgtg 2160
cccaaagagt tcaatgctga gacattcacc ttccatgctg acatctgcac cctgtctgag 2220
aaagagaggc agatcaagaa acagactgcc ctggtggaac tggtcaagca caagcccaag 2280
gccaccaaag aacaactgaa ggcagtgatg gatgactttg ctgcctttgt tgagaagtgc 2340
tgtaaagcag atgacaaaga gacatgcttt gctgaagagg gcaagaaact ggtggctgcc 2400
tctcaggctg ctctgggact ttaa 2424
<210> 55
<211> 2433
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic
<400> 55
ggtaaccaag ccaccatgaa atgggtcaca ttcatcagcc tgctgtttct gttcagctct 60
gcctacagca ggggagtgtt cagaagagat gcccacaagt ctgaggtggc ccacagattc 120
aaggacctgg gagaagagaa cttcaaggcc ctggtgctga ttgcctttgc tcagtacctc 180
cagcagtgcc cctttgagga ccatgtgaag ctggtcaatg aagtgacaga gtttgccaag 240
acctgtgtgg ctgatgagtc tgctgagaac tgtgacaaga gcctgcacac cctgtttgga 300
gacaagctgt gtacagtggc cacactgaga gaaacctatg gagagatggc tgactgctgt 360
gccaagcaag aacctgagag gaatgagtgc ttcctccagc acaaggatga caaccccaac 420
ctgcctagac ttgtcagacc tgaagtggat gtgatgtgca cagccttcca tgacaatgag 480
gaaaccttcc tgaagaaata cctgtatgag attgccagaa ggcaccccta cttctatgcc 540
cctgagctgc tgttctttgc taagagatac aaggctgcct ttacagagtg ctgccaggct 600
gctgacaaag ctgcctgtct gctgcccaag ctggatgagc tgagagatga aggcaaggcc 660
tcctctgcca agcagagact gaagtgtgcc agcctccaga agtttggaga gagagccttc 720
aaggcttggg ctgttgccag actgagccag agattcccca aggctgagtt tgctgaggtg 780
tccaagctgg ttacagacct gaccaaggtg cacactgaat gctgccatgg ggacctgctg 840
gaatgtgctg atgacagagc tgacctggcc aagtacatct gtgaaaacca ggacagcatc 900
agcagcaagc tgaaagaatg ctgtgaaaag cccctcctgg aaaagagcca ctgcattgca 960
gaggtggaaa atgatgagat gcctgctgat ctgcccagcc ttgcagctga ctttgtggaa 1020
agcaaggatg tgtgcaagaa ctatgctgag gccaaagatg tgttcctggg catgttcctc 1080
tatgagtatg ctagaaggca tcctgactac tctgtggtgc tgctgctgag actggctaag 1140
acctatgaga caacactgga aaagtgctgt gcagctgctg accctcatga gtgctatgcc 1200
aaagtgtttg atgagttcaa gcctctggtg gaagaacccc agaacctgat caagcagaat 1260
tgtgaactgt ttgagcagct gggagagtac aagttccaga atgccctgct tgtcagatac 1320
accaagaagg tgccccaggt ttccacacct acactggttg aagtgtccag aaatctgggc 1380
aaagtgggca gcaagtgctg caagcaccca gaggccaaga ggatgccatg tgctgaggac 1440
tacctgtcag tggtgctgaa ccagctgtgt gtcctgcatg agaaaacccc tgtgtctgac 1500
agagtgacaa agtgttgcac agagagcctg gtcaacagaa ggccttgctt ctctgccctg 1560
gaagttgatg agacatatgt gcccaaagag ttcaatgctg agacattcac cttccatgct 1620
gacatctgca ccctgtctga gaaagagagg cagatcaaga aacagactgc cctggtggaa 1680
ctggtcaagc acaagcccaa ggccaccaaa gaacaactga aggcagtgat ggatgacttt 1740
gctgcctttg ttgagaagtg ctgtaaagca gatgacaaag agacatgctt tgctgaagag 1800
ggcccgaaac tggtggctgc ctctcaggct gctctgggac ttggtggagg aggtagtttc 1860
cctacaatcc ctctgagcag gctgtttgac aatgccatgc tgagagccca cagactgcac 1920
cagctggcct ttgacaccta ccaagagttt gaagaggctt acatccccaa agagcagaag 1980
tacagcttcc tccagaatcc tcagaccagc ctgtgcttct ctgagagcat ccccacacct 2040
agcaacagag aggaaaccca gcagaagtcc aacctggaac tgctgagaat cagcctgctg 2100
ctgatccaga gctggctgga acctgtgcag ttcctgagat cagtgtttgc caacagcctg 2160
gtgtatgggg cctctgacag caatgtgtat gacctgctga aggacctgga agagggcatc 2220
cagacactga tgggcagact ggaagatggc agccccagaa caggccagat tttcaagcag 2280
acctacagca agtttgacac caacagccac aatgatgatg ccctgctcaa gaactatggg 2340
ctgctgtact gcttcagaaa ggacatggac aaggtggaaa ccttcctgag gattgtgcag 2400
tgcagaagtg tggaaggcag ctgtggcttc tga 2433
<210> 56
<211> 738
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic
<400> 56
atggctacag gcagcagaac ctctctgctg ctggcttttg gcctgctgtg tctgccttgg 60
ctgcaagagg gctctgcttt ccctacaatc cctctgagca ggctgtttga caatgccatg 120
ctgagagccc acagactgca ccagctggcc tttgacacct accaagagtt tgaagaggct 180
tacatcccca aagagcagaa gtacagcttc ctccagaatc ctcagaccag cctgtgcttc 240
tctgagagca tccccacacc tagcaacaga gaggaaaccc agcagaagtc caacctggaa 300
ctgctgagaa tcagcctgct gctgatccag agctggctgg aacctgtgca gttcctgaga 360
tcagtgtttg ccaacagcct ggtgtatggg gcctctgaca gcaatgtgta tgacctgctg 420
aaggacctgg aagagggcat ccagacactg atgggcagac tggaagatgg cagccccaga 480
acaggccaga ttttcaagca gacctacagc aagtttgaca ccaacagcca caatgatgat 540
gccctgctca agaactatgg gctgctgtac tgcttcagaa aggacatgga caaggtggaa 600
accttcctga ggattgtgca gtgcagaagt gtggaaggca gctgtggctt cagcagctcc 660
tctaaggctc cacctcctag ccttccatct ccttctaggc tgcctgggcc aagtgacaca 720
cccattctgc cacagtga 738
<210> 57
<211> 822
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic
<400> 57
atggctacag gcagcagaac ctctctgctg ctggcttttg gcctgctgtg tctgccttgg 60
ctgcaagagg gctctgccag ctctagctct aaggcccctc caccttctct gccatctcca 120
agcagactgc ctggaccttc tgacacccct atcctgcctc agttccctac aatccctctg 180
agcaggctgt ttgacaatgc catgctgaga gcccacagac tgcaccagct ggcctttgac 240
acctaccaag agtttgaaga ggcttacatc cccaaagagc agaagtacag cttcctccag 300
aatcctcaga ccagcctgtg cttctctgag agcatcccca cacctagcaa cagagaggaa 360
acccagcaga agtccaacct ggaactgctg agaatcagcc tgctgctgat ccagagctgg 420
ctggaacctg tgcagttcct gagatcagtg tttgccaaca gcctggtgta tggggcctct 480
gacagcaatg tgtatgacct gctgaaggac ctggaagagg gcatccagac actgatgggc 540
agactggaag atggcagccc cagaacaggc cagattttca agcagaccta cagcaagttt 600
gacaccaaca gccacaatga tgatgccctg ctcaagaact atgggctgct gtactgcttc 660
agaaaggaca tggacaaggt ggaaaccttc ctgaggattg tgcagtgcag aagtgtggaa 720
ggcagctgtg gcttcagcag ctcctctaag gctccacctc ctagccttcc atctccttct 780
aggctgcctg ggccaagtga cacacccatt ctgccacagt ga 822
<210> 58
<211> 738
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic
<400> 58
atggctacag gcagcagaac ctctctgctg ctggcttttg gcctgctgtg tctgccttgg 60
ctgcaagagg gctctgccag ctctagctct aaggcccctc caccttctct gccatctcca 120
agcagactgc ctggaccttc tgacacccct atcctgcctc agttccctac aatccctctg 180
agcaggctgt ttgacaatgc catgctgaga gcccacagac tgcaccagct ggcctttgac 240
acctaccaag agtttgaaga ggcttacatc cccaaagagc agaagtacag cttcctccag 300
aatcctcaga ccagcctgtg cttctctgag agcatcccca cacctagcaa cagagaggaa 360
acccagcaga agtccaacct ggaactgctg agaatcagcc tgctgctgat ccagagctgg 420
ctggaacctg tgcagttcct gagatcagtg tttgccaaca gcctggtgta tggggcctct 480
gacagcaatg tgtatgacct gctgaaggac ctggaagagg gcatccagac actgatgggc 540
agactggaag atggcagccc cagaacaggc cagattttca agcagaccta cagcaagttt 600
gacaccaaca gccacaatga tgatgccctg ctcaagaact atgggctgct gtactgcttc 660
agaaaggaca tggacaaggt ggaaaccttc ctgaggattg tgcagtgcag aagtgtggaa 720
ggcagctgtg gcttctga 738
<210> 59
<211> 3393
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic
<400> 59
atggccacag gcagcagaac atctctgctg ctggcttttg gcctgctgtg cctgccttgg 60
ctgcaagagg gaagtgctgc tgaacctgct ggcagcccta caagcacaga agagggaaca 120
cctggctctg gcacagcttc ttctagccct ggaagcagca caccttctgg tgctacagga 180
tctcctgggg cctctcctgg aacatcttct acaggttctc caggcagccc tgctggctct 240
cctacatcta cagaggaagg cacctctgag tctgccacac ctgagtctgg acctggcacc 300
tctacagagc catctgaagg atctgctcca ggctcaccag ctggctcccc aacttcaact 360
gaagagggca caagcactga accctctgag ggctctgccc ctggaacttc aacagaacct 420
tcagagggat cagccccagg gacatcagag tctgctactc cagaatctgg cccaggctct 480
gagccagcca catctggatc tgagacacca ggatcagaac ctgccacctc tggctctgaa 540
acccctggat ctccagcagg ctctcccact agcactgagg aagggacatc tgaatcagca 600
accccagaga gtggccctgg caccagtact gaaccatcag aaggctcagc acctgggacc 660
agcacagaac catctgaggg tagtgctcca ggttctcctg ctggaagccc aacctccaca 720
gaagaaggta ctagcactga gccaagtgaa ggctctgccc caggcacatc aactgagcca 780
tcagaaggat ctgcccctgg cacctctgaa agtgctaccc ctgaatcagg accagggacc 840
tcaactgaac ctagtgaagg atcagctcct ggaacttctg aatcagccac tcctgaatca 900
ggccctggaa gtgaaccagc tacttcagga tctgaaactc caggcacttc cacagaaccc 960
tcagaaggct ctgctccagg gacttctact gaaccatctg agggatcagc accaggcacc 1020
agtgaatctg caaccccaga atctggacct ggaacaagtg aatcagctac ccctgagtct 1080
ggcccaggat caccagcagg atcacctacc tctactgaag agggaacctc agaaagtgcc 1140
actccagaga gtggaccagg atctgagcca gctacttcag gctcagagac acctggcaca 1200
tctgaatctg ctacaccaga gtcaggccct gggacatcca ctgagccatc tgaaggcagt 1260
gcaccaggca cctccactga accatctgaa ggctcagccc caggcacttc tacagaaccc 1320
agtgaaggat ctgcaccagg gaccagtact gaaccttctg aaggatctgc tcctggcacc 1380
agcacagagc caagtgaagg atcagcacct ggcacctcaa ctgaaccctc tgagggaagt 1440
gctcctggca gtcctgctgg atcaccaacc agcactgaag aggggacctc tacagaaccc 1500
tctgagggat ctgcacctgg gacctctgag tcagcaacac cagaatcagg tcctggctct 1560
gaacctgcta cttctggtag tgaaacccca gggacctctg aaagtgcaac accagagtct 1620
ggccctggat ctgaaccagc aaccagtggc tctgagactc ctggtacttc agagagtgca 1680
acacctgaaa gtggcccagg gaccagcaca gagccatcag aaggctctgc accaggcaca 1740
tctgagtctg ctacccctga aagtggacct ggctctcctg ctgggagtcc cacaagtact 1800
gaagaaggtt ccccagcagg gtccccaaca tccactgaag aaggatcacc agctggcagc 1860
cccacttcca cagaggaagg cacatcagaa tcagctactc cagagtctgg acctggtact 1920
agcacagaac catcagaggg aagtgcccct ggaacatctg agagtgccac accagaatca 1980
ggacctggat ctgagccagc cacctctggt agtgaaactc ctggtacttc tgagtctgca 2040
accccagagt caggcccagg atcagaacca gctacttctg gcagtgaaac acctggcacc 2100
tcagaatcag caacacctga atctggacca ggcactagca cagaaccatc tgaaggatca 2160
gcccctggct ctcctgctgg ctctccaact tctacagaag agggaacttc tgaaagtgca 2220
actcctgaat ctggaccagg atctgaacct gcaacttctg gatcagagac accagggacc 2280
tcagagagtg ctactcctga gtcaggtcct ggcagcccag ctggaagccc cacaagtaca 2340
gaggaaggat ctcctgctgg gtcccctacc agtacagaag aaggcacttc tactgaaccc 2400
tcagaaggat cagcccctgg tacaagtgaa tctgccactc cagagtcagg accaggcact 2460
tcagagtcag caactcctga gagtggtcca ggcacttcag aaagtgctac cccagagtct 2520
ggtccaggca gtgaacctgc tacaagtggc tctgaaacac caggctctga accagctact 2580
tctggctctg agactcctgg ctcaccagct ggcagtccta cctctacaga agaagggact 2640
tcaacagaac catctgaggg cagtgcacct ggcacaagca cagagccatc tgaaggatct 2700
gcacctggat ctgaaccagc tacctctgga tcagaaaccc ctggaacctc tgaatcagct 2760
accccagaaa gtggaccagg cacatccaca gaaccatcag agggatctgc accaggattc 2820
cctacaatcc cactgagcag actgtttgac aatgccatgc tgagagccca cagactgcat 2880
cagctggcct ttgacaccta ccaagagttt gaagaggctt acatccccaa agagcagaag 2940
tacagcttcc tgcaaaaccc acagaccagc ctgtgcttct ctgagagcat ccccacacct 3000
agcaacagag aggaaaccca gcagaagtcc aatctggaac tgctgagaat ctcactgctg 3060
ctgatccagt cttggctgga acctgtgcag ttcctgagat cagtgtttgc caacagtctg 3120
gtgtatgggg cttctgacag caatgtgtat gacctgctga aagacctgga agagggtatc 3180
cagacactga tgggcagact ggaagatggc tcccctagaa caggccagat tttcaagcag 3240
acctacagca agtttgacac caacagccac aatgatgatg ccctgctcaa gaactatggg 3300
ctgctgtact gtttcagaaa ggacatggac aaggtggaaa ccttcctgag aattgtgcag 3360
tgcagaagtg tggaaggcag ctgtggcttt tga 3393
<210> 60
<211> 3831
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic
<400> 60
atggccacag gcagcagaac atctctgctg ctggcttttg gcctgctgtg cctgccttgg 60
ctgcaagagg gaagtgctgc tgaacctgct ggcagcccta caagcacaga agagggaaca 120
cctggctctg gcacagcttc ttctagccct ggaagcagca caccttctgg tgctacagga 180
tctcctgggg cctctcctgg aacatcttct acaggttctc caggcagccc tgctggctct 240
cctacatcta cagaggaagg cacctctgag tctgccacac ctgagtctgg acctggcacc 300
tctacagagc catctgaagg atctgctcca ggctcaccag ctggctcccc aacttcaact 360
gaagagggca caagcactga accctctgag ggctctgccc ctggaacttc aacagaacct 420
tcagagggat cagccccagg gacatcagag tctgctactc cagaatctgg cccaggctct 480
gagccagcca catctggatc tgagacacca ggatcagaac ctgccacctc tggctctgaa 540
acccctggat ctccagcagg ctctcccact agcactgagg aagggacatc tgaatcagca 600
accccagaga gtggccctgg caccagtact gaaccatcag aaggctcagc acctgggacc 660
agcacagaac catctgaggg tagtgctcca ggttctcctg ctggaagccc aacctccaca 720
gaagaaggta ctagcactga gccaagtgaa ggctctgccc caggcacatc aactgagcca 780
tcagaaggat ctgcccctgg cacctctgaa agtgctaccc ctgaatcagg accagggacc 840
tcaactgaac ctagtgaagg atcagctcct ggaacttctg aatcagccac tcctgaatca 900
ggccctggaa gtgaaccagc tacttcagga tctgaaactc caggcacttc cacagaaccc 960
tcagaaggct ctgctccagg gacttctact gaaccatctg agggatcagc accaggcacc 1020
agtgaatctg caaccccaga atctggacct ggaacaagtg aatcagctac ccctgagtct 1080
ggcccaggat caccagcagg atcacctacc tctactgaag agggaacctc agaaagtgcc 1140
actccagaga gtggaccagg atctgagcca gctacttcag gctcagagac acctggcaca 1200
tctgaatctg ctacaccaga gtcaggccct gggacatcca ctgagccatc tgaaggcagt 1260
gcaccaggca cctccactga accatctgaa ggctcagccc caggcacttc tacagaaccc 1320
agtgaaggat ctgcaccagg gaccagtact gaaccttctg aaggatctgc tcctggcacc 1380
agcacagagc caagtgaagg atcagcacct ggcacctcaa ctgaaccctc tgagggaagt 1440
gctcctggca gtcctgctgg atcaccaacc agcactgaag aggggacctc tacagaaccc 1500
tctgagggat ctgcacctgg gacctctgag tcagcaacac cagaatcagg tcctggctct 1560
gaacctgcta cttctggtag tgaaacccca gggacctctg aaagtgcaac accagagtct 1620
ggccctggat ctgaaccagc aaccagtggc tctgagactc ctggtacttc agagagtgca 1680
acacctgaaa gtggcccagg gaccagcaca gagccatcag aaggctctgc accaggcaca 1740
tctgagtctg ctacccctga aagtggacct ggctctcctg ctgggagtcc cacaagtact 1800
gaagaaggtt ccccagcagg gtccccaaca tccactgaag aaggatcacc agctggcagc 1860
cccacttcca cagaggaagg cacatcagaa tcagctactc cagagtctgg acctggtact 1920
agcacagaac catcagaggg aagtgcccct ggaacatctg agagtgccac accagaatca 1980
ggacctggat ctgagccagc cacctctggt agtgaaactc ctggtacttc tgagtctgca 2040
accccagagt caggcccagg atcagaacca gctacttctg gcagtgaaac acctggcacc 2100
tcagaatcag caacacctga atctggacca ggcactagca cagaaccatc tgaaggatca 2160
gcccctggct ctcctgctgg ctctccaact tctacagaag agggaacttc tgaaagtgca 2220
actcctgaat ctggaccagg atctgaacct gcaacttctg gatcagagac accagggacc 2280
tcagagagtg ctactcctga gtcaggtcct ggcagcccag ctggaagccc cacaagtaca 2340
gaggaaggat ctcctgctgg gtcccctacc agtacagaag aaggcacttc tactgaaccc 2400
tcagaaggat cagcccctgg tacaagtgaa tctgccactc cagagtcagg accaggcact 2460
tcagagtcag caactcctga gagtggtcca ggcacttcag aaagtgctac cccagagtct 2520
ggtccaggca gtgaacctgc tacaagtggc tctgaaacac caggctctga accagctact 2580
tctggctctg agactcctgg ctcaccagct ggcagtccta cctctacaga agaagggact 2640
tcaacagaac catctgaggg cagtgcacct ggcacaagca cagagccatc tgaaggatct 2700
gcacctggat ctgaaccagc tacctctgga tcagaaaccc ctggaacctc tgaatcagct 2760
accccagaaa gtggaccagg cacatccaca gaaccatcag agggatctgc accaggattc 2820
cctacaatcc cactgagcag actgtttgac aatgccatgc tgagagccca cagactgcat 2880
cagctggcct ttgacaccta ccaagagttt gaagaggctt acatccccaa agagcagaag 2940
tacagcttcc tgcaaaaccc acagaccagc ctgtgcttct ctgagagcat ccccacacct 3000
agcaacagag aggaaaccca gcagaagtcc aatctggaac tgctgagaat ctcactgctg 3060
ctgatccagt cttggctgga acctgtgcag ttcctgagat cagtgtttgc caacagtctg 3120
gtgtatgggg cttctgacag caatgtgtat gacctgctga aagacctgga agagggtatc 3180
cagacactga tgggcagact ggaagatggc tcccctagaa caggccagat tttcaagcag 3240
acctacagca agtttgacac caacagccac aatgatgatg ccctgctcaa gaactatggg 3300
ctgctgtact gtttcagaaa ggacatggac aaggtggaaa ccttcctgag aattgtgcag 3360
tgcagaagtg tggaaggcag ctgtggcttt ggagggacct cagaatctgc cactcctgag 3420
tctggcccag ggacaagtac agaaccatct gagggctctg ctccaggcac cagtacagaa 3480
ccatcagaag gatctgcccc agggacttca gaatcagcca caccagaaag tggtcctgga 3540
accagcactg aaccatcaga gggatcagcc cctggcacta gcactgaacc atctgaggga 3600
agtgcaccag ggacctcaga atctgctacc cctgaatcag gccctggcac ctccacagaa 3660
cccagtgaag gcagtgctcc tggcacatct acagaaccct cagaaggatc tgctcctggc 3720
acatccacag aaccctctga gggcagtgcc ccaggatcac cagctggaag tccaactagc 3780
acagaagagg gcaccagtac agagccaagt gaaggcagtg cccctggatg a 3831
<210> 61
<211> 1092
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic
<400> 61
atggccacag gcagcagaac atctctgctg ctggcttttg gcctgctgtg cctgccttgg 60
ctgcaagagg gaagtgcttt ccctacaatc ccactgagca gactgtttga caatgccatg 120
ctgagagccc acagactgca tcagctggcc tttgacacct accaagagtt tgaagaggct 180
tacatcccca aagagcagaa gtacagcttc ctgcaaaacc cacagaccag cctgtgcttc 240
tctgagagca tccccacacc tagcaacaga gaggaaaccc agcagaagtc caatctggaa 300
ctgctgagaa tctcactgct gctgatccag tcttggctgg aacctgtgca gttcctgaga 360
tcagtgtttg ccaacagtct ggtgtatggg gcttctgaca gcaatgtgta tgacctgctg 420
aaagacctgg aagagggtat ccagacactg atgggcagac tggaagatgg ctcccctaga 480
acaggccaga ttttcaagca gacctacagc aagtttgaca ccaacagcca caatgatgat 540
gccctgctca agaactatgg gctgctgtac tgtttcagaa aggacatgga caaggtggaa 600
accttcctga gaattgtgca gtgcagaagt gtggaaggca gctgtggctt tggagggacc 660
tcagaatctg ccactcctga gtctggccca gggacaagta cagaaccatc tgagggctct 720
gctccaggca ccagtacaga accatcagaa ggatctgccc cagggacttc agaatcagcc 780
acaccagaaa gtggtcctgg aaccagcact gaaccatcag agggatcagc ccctggcact 840
agcactgaac catctgaggg aagtgcacca gggacctcag aatctgctac ccctgaatca 900
ggccctggca cctccacaga acccagtgaa ggcagtgctc ctggcacatc tacagaaccc 960
tcagaaggat ctgctcctgg cacatccaca gaaccctctg agggcagtgc cccaggatca 1020
ccagctggaa gtccaactag cacagaagag ggcaccagta cagagccaag tgaaggcagt 1080
gcccctggat ga 1092
<210> 62
<211> 9795
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic
<400> 62
cactatgtgt taattaaaat tatctctaag gcatgtgaac tggctgtctt ggttttcatc 60
tgtacttcat ctgctacctc tgtgacctga aacatattta taattccatt aagctgtgca 120
tatgatagat ttatcatatg tattttcctt aaaggatttt tgtaagaact aattgaattg 180
atacctgtaa agtctttatc acactaccca ataaataata aatctctttg ttcagctctc 240
tgtttctata aatatgtacc agttttattg tttttagtgg tagtgatttt attctctttc 300
tatatatata cacacacatg tgtgcattca taaatatata caatttttat gaataaaaaa 360
ttattagcaa tcaatattga aaaccactga tttttgttta tgtgagcaaa cagcagatta 420
aaaggaattt gaattctcat agctagcagg agtcaatggg aaaaacccat tggagccaag 480
tacactgact caatagggac tttccattgg gttttgccca gtacataagg tcaatagggg 540
gtgagtcaac aggaaagtcc cattggagcc aagtacattg agtcaatagg gactttccaa 600
tgggttttgc ccagtacata aggtcaatgg gaggtaagcc aatgggtttt tcccattact 660
gacatgtata ctgagtcatt agggactttc caatgggttt tgcccagtac ataaggtcaa 720
taggggtgaa tcaacaggaa agtcccattg gagccaagta cactgagtca atagggactt 780
tccattgggt tttgcccagt acaaaaggtc aatagggggt gagtcaatgg gtttttccca 840
ttattggcac atacataagg tcaatagggg tgactagtgg agaagagcat gcttgagggc 900
tgagtgcccc tcagtgggca gagagcacat ggcccacagt ccctgagaag ttggggggag 960
gggtgggcaa ttgaactggt gcctagagaa ggtggggctt gggtaaactg ggaaagtgat 1020
gtggtgtact ggctccacct ttttccccag ggtgggggag aaccatatat aagtgcagta 1080
gtctctgtga acattcaagc ttctgccttc tccctcctgt gagtttggta agtcactgac 1140
tgtctatgcc tgggaaaggg tgggcaggag atggggcagt gcaggaaaag tggcactatg 1200
aaccctgcag ccctagacaa ttgtactaac cttcttctct ttcctctcct gacaggttgg 1260
taaccaagcc accatgaact ttggcctgag cctgatcttc ctggtgctga tcctgaaagg 1320
ggtgcagtgt gaagtgcagc tggtggaatc tggggctgaa gtgaagaaac ctggggcctc 1380
tgtgaaggtg tcctgcaaag tgtctggcta caccctgaca gagctgagca tgcactgggt 1440
cagacaggcc cctggcaaag gccttgaatg gatgggaggc tttgaccctg aggatgggga 1500
gactatgtat gcccagaaat tccagggcag agtgaccatg acagaggaca ccagcacaga 1560
cacagcctac atggaactga gcagccttag gagtgaagat acagctgtgt actactgtgc 1620
caccagcact gctgtggctg gcacccctga cctgtttgac tactactatg gcatggatgt 1680
gtggggccag ggcaccacag tgacagtcag ctctgcttcc acaaagggcc cctctgtgtt 1740
ccctctggct cctagcagca agagcaccag tggtggaaca gctgccctgg gctgtctggt 1800
caaggactac tttcctgagc cagtgactgt gtcctggaac agtggggctc tgacatctgg 1860
ggtgcacaca ttccctgctg tgctccagtc ctctggcctg tacagcctct cctctgtggt 1920
cactgtgcca agctctagcc tgggcaccca gacctacatc tgcaatgtga accacaagcc 1980
tagcaacacc aaggtggaca agaaggctga gcccaagagc tgtgacaaga cccacacctg 2040
tcctccatgt cctgctccag agctgcttgg aggaccttct gtgtttctgt tccctccaaa 2100
gcctaaggac accctgatga tcagcagaac ccctgaagtg acctgtgtgg tggtggatgt 2160
gtcccatgag gacccagaag tgaagttcaa ttggtatgtg gatggtgttg aggtgcacaa 2220
tgccaagacc aagcctagag aggaacagta caacagcacc tacagagtgg tgtcagtgct 2280
gacagtgctg caccaggact ggctgaatgg caaagagtac aagtgcaagg tgtccaacaa 2340
ggccctgcct gctcctattg aaaagaccat cagcaaggcc aagggccagc ctagggaacc 2400
ccaagtgtat accctgccac ctagcagaga tgagctgacc aagaaccagg tgtccctgac 2460
atgcctggtt aagggcttct acccctctga cattgctgtg gaatgggaga gcaatggcca 2520
gcctgagaac aactacaaga caacccctcc tgtgctggac tctgatggct cattcttcct 2580
gtactccaag ctcacagtgg acaagtccag atggcagcaa ggcaatgtgt tcagctgctc 2640
tgtgatgcat gaggccctgc acaaccacta cacacagaag tccctgtctc tgagccctgg 2700
caagagaaag agaaggagtg gctctggggc caccaacttc agcctgctga aacaggctgg 2760
ggatgttgaa gagaaccctg gacctatggc ctgggctctg ctgctgctgg gactgctgtc 2820
tcactgcaca ggctctgtga cagagattgt gatgacacag agccctctgt ctagccctgt 2880
gacactggga cagcctgcca gcatcagctg tagaagctct cagagtctgg tgcattctga 2940
tggcaacacc tacctgagct ggctgcaaca gaggcctgga cagccaccta gactgctgat 3000
ctacaagatc agcaacaggt tctctggggt cccagacaga ttctctggaa gtggtgctgg 3060
cacagacttc actctgaaga ttagcagagt ggaagctgag gatgttgggg tgtactattg 3120
cacccaggcc acacagttcc cttacacctt tggccaggga acaaaagtgg acatcaaggg 3180
caccaaactg actgtgctgg gccagccaaa ggctgcccct tctgtgactc tgtttccacc 3240
tagctctgag gaactccagg ctaacaaggc cacacttgtg tgcctgatct ctgacttcta 3300
ccctggggct gtgacagtgg cctggaaggc tgatagcagc ccagtgaagg ctggggttga 3360
gacaaccaca cctagcaagc agagcaacaa caaatatgct gccagcagct acctgagtct 3420
gacccctgag cagtggaagt cccacagatc ctacagctgc caagtgaccc atgagggctc 3480
tacagtggaa aagactgtgg ccccaacaga gtgcagctga agatctactt ctggctaata 3540
aaagatcaga gctctagtga tctgtgtgtt ggttttttgt gtctgcattc tagcagagcc 3600
ccactgtgtt catcttacag atggaaatac tgacattcag aggagttagt taacttgcct 3660
aggtgattca gctaataagt gcaagaaaga tttcaatcca aggtgatttg attctgaagc 3720
ctgtgctaat cacattacac caagctacaa cttcatttat aaataataag tcagctttca 3780
agggcctttc aggtgtcctg cacttctaca agctgtgcca tttagtgaac acaaaatgag 3840
ccttctgatg aagtagtctt ttcattattt cagatattag aacactaaaa ttcttagctg 3900
ccagctgatt gaaggctggg acaaaattca aacatgcatc tacaacaata tatatctcaa 3960
tgttagtctc caaattctat tgacttcaac tcaagagaat ataaagagct agtctttata 4020
cactctttaa ggtatgatat catctggaaa gtaacaaaat tgatgcaaat ttgaatgaac 4080
tttatcatgg tgtatttaca caatgtgttt cttctccctg caatgtattt ctttctctaa 4140
ttccttccat ttgatctttc atacacaatc tggttctgat gtatgttttt tggatgcact 4200
tttcaactcc aaaagacaga gctagttact ttcttcctgg tgctccaagc actgtatttg 4260
tatctgtatt caagcccttt gcaatattgt actggatcat tatttcacct ctaggatggc 4320
ttccccaggc aacttgtgtt cacccagaga ctacattttg tatcttgttg acctttgaac 4380
ttccaccagt gtctaaaaat aatatgtatg caaaattact tgctatgaga atgtataatt 4440
aaacaatata aaaaggagaa gcaaggagag aaacacaggt gtgtatttgt gtttgtgtgc 4500
ttaaaaggca gtgtggaaaa ggaagaaatg ccatttatag tgaggagaca aagttatatt 4560
acctcttatc tggcttttaa ggagattttg ctgagctaaa aatcctatat tcatagaaaa 4620
gccttacctg agttgccaat acctcaattc agtctagcag gagtcaatgg gaaaaaccca 4680
ttggagccaa gtacactgac tcaataggga ctttccattg ggttttgccc agtacataag 4740
gtcaataggg ggtgagtcaa caggaaagtc ccattggagc caagtacatt gagtcaatag 4800
ggactttcca atgggttttg cccagtacat aaggtcaatg ggaggtaagc caatgggttt 4860
ttcccattac tgacatgtat actgagtcat tagggacttt ccaatgggtt ttgcccagta 4920
cataaggtca ataggggtga atcaacagga aagtcccatt ggagccaagt acactgagtc 4980
aatagggact ttccattggg ttttgcccag tacaaaaggt caataggggg tgagtcaatg 5040
ggtttttccc attattggca catacataag gtcaataggg gtgactagtg gagaagagca 5100
tgcttgaggg ctgagtgccc ctcagtgggc agagagcaca tggcccacag tccctgagaa 5160
gttgggggga ggggtgggca attgaactgg tgcctagaga aggtggggct tgggtaaact 5220
gggaaagtga tgtggtgtac tggctccacc tttttcccca gggtggggga gaaccatata 5280
taagtgcagt agtctctgtg aacattcaag cttctgcctt ctccctcctg tgagtttggt 5340
aagtcactga ctgtctatgc ctgggaaagg gtgggcagga gatggggcag tgcaggaaaa 5400
gtggcactat gaaccctgca gccctagaca attgtactaa ccttcttctc tttcctctcc 5460
tgacaggttg gtaaccaagc caccatgaac tttggcctga gcctgatctt cctggtgctg 5520
atcctgaaag gggtgcagtg tgaagtgcag ctggtggaat ctggggctga agtgaagaaa 5580
cctggggcct ctgtgaaggt gtcctgcaaa gtgtctggct acaccctgac agagctgagc 5640
atgcactggg tcagacaggc ccctggcaaa ggccttgaat ggatgggagg ctttgaccct 5700
gaggatgggg agactatgta tgcccagaaa ttccagggca gagtgaccat gacagaggac 5760
accagcacag acacagccta catggaactg agcagcctta ggagtgaaga tacagctgtg 5820
tactactgtg ccaccagcac tgctgtggct ggcacccctg acctgtttga ctactactat 5880
ggcatggatg tgtggggcca gggcaccaca gtgacagtca gctctgcttc cacaaagggc 5940
ccctctgtgt tccctctggc tcctagcagc aagagcacca gtggtggaac agctgccctg 6000
ggctgtctgg tcaaggacta ctttcctgag ccagtgactg tgtcctggaa cagtggggct 6060
ctgacatctg gggtgcacac attccctgct gtgctccagt cctctggcct gtacagcctc 6120
tcctctgtgg tcactgtgcc aagctctagc ctgggcaccc agacctacat ctgcaatgtg 6180
aaccacaagc ctagcaacac caaggtggac aagaaggctg agcccaagag ctgtgacaag 6240
acccacacct gtcctccatg tcctgctcca gagctgcttg gaggaccttc tgtgtttctg 6300
ttccctccaa agcctaagga caccctgatg atcagcagaa cccctgaagt gacctgtgtg 6360
gtggtggatg tgtcccatga ggacccagaa gtgaagttca attggtatgt ggatggtgtt 6420
gaggtgcaca atgccaagac caagcctaga gaggaacagt acaacagcac ctacagagtg 6480
gtgtcagtgc tgacagtgct gcaccaggac tggctgaatg gcaaagagta caagtgcaag 6540
gtgtccaaca aggccctgcc tgctcctatt gaaaagacca tcagcaaggc caagggccag 6600
cctagggaac cccaagtgta taccctgcca cctagcagag atgagctgac caagaaccag 6660
gtgtccctga catgcctggt taagggcttc tacccctctg acattgctgt ggaatgggag 6720
agcaatggcc agcctgagaa caactacaag acaacccctc ctgtgctgga ctctgatggc 6780
tcattcttcc tgtactccaa gctcacagtg gacaagtcca gatggcagca aggcaatgtg 6840
ttcagctgct ctgtgatgca tgaggccctg cacaaccact acacacagaa gtccctgtct 6900
ctgagccctg gcaagagaaa gagaaggagt ggctctgggg ccaccaactt cagcctgctg 6960
aaacaggctg gggatgttga agagaaccct ggacctatgg cctgggctct gctgctgctg 7020
ggactgctgt ctcactgcac aggctctgtg acagagattg tgatgacaca gagccctctg 7080
tctagccctg tgacactggg acagcctgcc agcatcagct gtagaagctc tcagagtctg 7140
gtgcattctg atggcaacac ctacctgagc tggctgcaac agaggcctgg acagccacct 7200
agactgctga tctacaagat cagcaacagg ttctctgggg tcccagacag attctctgga 7260
agtggtgctg gcacagactt cactctgaag attagcagag tggaagctga ggatgttggg 7320
gtgtactatt gcacccaggc cacacagttc ccttacacct ttggccaggg aacaaaagtg 7380
gacatcaagg gcaccaaact gactgtgctg ggccagccaa aggctgcccc ttctgtgact 7440
ctgtttccac ctagctctga ggaactccag gctaacaagg ccacacttgt gtgcctgatc 7500
tctgacttct accctggggc tgtgacagtg gcctggaagg ctgatagcag cccagtgaag 7560
gctggggttg agacaaccac acctagcaag cagagcaaca acaaatatgc tgccagcagc 7620
tacctgagtc tgacccctga gcagtggaag tcccacagat cctacagctg ccaagtgacc 7680
catgagggct ctacagtgga aaagactgtg gccccaacag agtgcagctg aagatctact 7740
tctggctaat aaaagatcag agctctagtg atctgtgtgt tggttttttg tgtctgcatt 7800
ctagcaagtc aatatgttca ccccaaaaaa gctgtttgtt aacttgtcaa cctcattcta 7860
aaatgtatat agaagcccaa aagacaataa caaaaatatt cttgtagaac aaaatgggaa 7920
agaatgttcc actaaatatc aagatttaga gcaaagcatg agatgtgtgg ggatagacag 7980
tgaggctgat aaaatagagt agagctcaga aacagaccca ttgatatatg taagtgacct 8040
atgaaaaaaa tatggcattt tacaatggga aaatgatggt ctttttcttt tttagaaaaa 8100
cagggaaata tatttatatg taaaaaataa aagggaaccc atatgtcata ccatacacac 8160
aaaaaaattc cagtgaatta taagtctaaa tggagaaggc aaaactttaa atcttttaga 8220
aaataatata gaagcatgcc atcaagactt cagtgtagag aaaaatttct tatgactcaa 8280
agtcctaacc acaaagaaaa gattgttaat tagattgcat gaatattaag acttattttt 8340
aaaattaaaa aaccattaag aaaagtcagg ccatagaatg acagaaaata tttgcaacac 8400
cccagtaaag agaattgtaa tatgcagatt ataaaaagaa gtcttacaaa tcagtaaaaa 8460
ataaaactag acaaaaattt gaacagatga aagagaaact ctaaataatc attacacatg 8520
agaaactcaa tctcagaaat cagagaacta tcattgcata tacactaaat tagagaaata 8580
ttaaaaggct aagtaacatc tgtggcttaa ttaatctagc tctagtgatc agcagttcaa 8640
cctgttgata gtatgtacta agctctcatg tttaatgtac taagctctca tgtttaatga 8700
actaaaccct catggctaat gtactaagct ctcatggcta atgtactaag ctctcatgtt 8760
tcatgtacta agctctcatg tttgaacaat aaaattaata taaatcagca acttaaatag 8820
cctctaaggt tttaagtttt ataagaaaaa aaagaatata taaggctttt aaaggtttta 8880
aggtttccta ggttatcctc atatgagctc ttagaaaaac tcatccagca tcaaatgaaa 8940
ctgcaattta ttcatatcag gattatcaat accatatttt tgaaaaagtc ttttctgtaa 9000
tgaaggagaa aactcaccca ggcagttcca taggatggca agatcctggt atctgtctgc 9060
aattccaact cttccaacat caatacaacc tattaatttc ccctcatcaa aaataaggtt 9120
atcaagtgag aaatcaccat gagtgaccac tgaatctggt gagaatggca aaagattatg 9180
catttctttc cagacttgtt caacaggcca gccatttctc tcatcatcaa aatcactggc 9240
atcaaccaaa ccattattca ttcttgattg ggcctgagcc agtctaaata ctctatcaga 9300
gttaaaagga caattacaaa caggaatgga atgcaatctt ctcaggaaca ctgccagggc 9360
atcaacaata ttttcacctg aatcaggata ttcttccaat acctggaatg ctgttttccc 9420
tgggatggca gtggtgagta accatgcatc atcaggagtt ctgataaaat gcttgatggt 9480
tggaagaggc ataaattcag tcagccagtt tagtctgacc atctcatctg taacatcatt 9540
ggcaacagaa cctttgccat gtttcagaaa caactctggg gcatctggct tcccatacaa 9600
tctatagatt gtggcacctg attgcccaac attatctcta gcccatttat acccatataa 9660
atcagcatcc atgttggaat ttaatcttgg cctggagcaa gaggtttctc tttgaatatg 9720
gctcatacat gtgcacctcc tatagtgagt tgtattatac tatgcagata tactatgcca 9780
atgtttaatt gtcag 9795
<210> 63
<211> 121
<212> PRT
<213> Homo sapiens
<400> 63
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Ser Gln Pro Gly Glu
1 5 10 15
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Gly Tyr
20 25 30
Trp Ile Ser Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
35 40 45
Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Lys Tyr Thr Pro Ser Phe
50 55 60
Gln Gly Gln Val Thr Ile Ser Thr Asp Lys Ser Ile Asn Thr Ala Tyr
65 70 75 80
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
85 90 95
Ala Arg Arg Gly Asp Gly Leu Tyr Tyr Tyr Gly Met Asp Val Trp Gly
100 105 110
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 64
<211> 124
<212> PRT
<213> Homo sapiens
<400> 64
Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Ala Ser Gly Gly Ser Ile Ser Thr Tyr
20 25 30
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
35 40 45
Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys
50 55 60
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
65 70 75 80
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Asp Arg Ile Ala Pro Val Gly Lys Phe Phe Gly Trp Tyr Phe Asp
100 105 110
Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 65
<211> 117
<212> PRT
<213> Homo sapiens
<400> 65
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val
35 40 45
Ser Gly Ile Ser Ser Asn Gly Gly Ser Thr Tyr Tyr Ala Asn Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Ile Gln Met Gly Ser Leu Arg Ala Glu Asp Met Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ser Ser Ser Arg Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu
100 105 110
Val Thr Val Ser Ser
115
<210> 66
<211> 124
<212> PRT
<213> Homo sapiens
<400> 66
Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Asp Ser Thr Ser Ser Ser
20 25 30
Ser Ser Tyr Trp Asp Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu
35 40 45
Trp Ile Gly Asn Ile Tyr Tyr Thr Gly Thr Thr Tyr Tyr Asn Pro Ser
50 55 60
Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asp Gln Phe
65 70 75 80
Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
85 90 95
Cys Ala Arg Glu Leu Phe Thr Ala Val Ala Gly Lys Gly Gly Ile Asp
100 105 110
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 67
<211> 129
<212> PRT
<213> Homo sapiens
<400> 67
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Pro Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Asp Phe Lys Gly Gly Ser Ser Ser Trp Tyr Thr Pro Glu Ile
100 105 110
Glu Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser
115 120 125
Ser
<210> 68
<211> 135
<212> PRT
<213> Homo sapiens
<400> 68
Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Ile Asn Thr Asn Thr Gly Asn Pro Thr Tyr Ala Gln Gly Phe
50 55 60
Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr
65 70 75 80
Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Leu Ile Arg His Glu Ala His Thr Tyr Cys Ser Gly Gly Ser
100 105 110
Cys Tyr Ser Pro Asp Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly
115 120 125
Thr Met Val Thr Val Ser Ser
130 135
<210> 69
<211> 120
<212> PRT
<213> Homo sapiens
<400> 69
Glu Val Gln Leu Leu Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Glu Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Tyr Ile Ser Thr Ser Gly Ser Thr Ile Asn Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Lys Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ser Asn Pro Pro Leu Gly Glu Pro Tyr Phe Asp Ile Trp Gly Gln
100 105 110
Gly Thr Met Val Thr Val Ser Ser
115 120
<210> 70
<211> 119
<212> PRT
<213> Homo sapiens
<400> 70
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Trp Gly Gly Gly Met Gln Tyr Leu Asp Val Trp Gly Gln Gly
100 105 110
Thr Thr Val Thr Val Ser Ser
115
<210> 71
<211> 126
<212> PRT
<213> Homo sapiens
<400> 71
Glu Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Ile Asn Thr Asn Thr Gly Asn Pro Thr Tyr Ala Gln Gly Phe
50 55 60
Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr
65 70 75 80
Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ala Gly Pro Asn Tyr Asp Phe Trp Ser Gly Tyr Tyr Gln Thr
100 105 110
Phe Asp Tyr Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120 125
<210> 72
<211> 124
<212> PRT
<213> Homo sapiens
<400> 72
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Thr Glu Leu
20 25 30
Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met
35 40 45
Gly Gly Phe Asp Pro Glu Asp Gly Glu Thr Ile Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Thr Ala Thr Ala Met Asp Gly Tyr Tyr Tyr Tyr Tyr Gly Met Asp
100 105 110
Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 73
<211> 121
<212> PRT
<213> Homo sapiens
<400> 73
Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr
20 25 30
Trp Ile Gly Trp Val Arg Gln Met Pro Gly Glu Gly Leu Glu Trp Met
35 40 45
Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe
50 55 60
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65 70 75 80
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
85 90 95
Ala Ser Ala Gly Ser Ser Trp Tyr Gly Asp Ala Phe Asp Ile Trp Gly
100 105 110
Gln Gly Thr Met Val Thr Val Ser Ser
115 120
<210> 74
<211> 122
<212> PRT
<213> Homo sapiens
<400> 74
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Val Ser Gly Cys Thr Leu Thr Glu Leu
20 25 30
Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met
35 40 45
Gly Gly Phe Asp Pro Glu Asp Gly Glu Thr Ile Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Thr Ala Thr Ile Phe Gly Val Ala Asn Asn Trp Phe Asp Pro Trp
100 105 110
Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 75
<211> 132
<212> PRT
<213> Homo sapiens
<400> 75
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Asp Leu Gly Tyr Tyr Asp Ile Leu Thr Gly Gln Leu Gly Gly
100 105 110
Tyr Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val
115 120 125
Thr Val Ser Ser
130
<210> 76
<211> 126
<212> PRT
<213> Homo sapiens
<400> 76
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Trp Asp Tyr Asp Ile Leu Thr Gly Ser Trp Phe Gly Ala
100 105 110
Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120 125
<210> 77
<211> 121
<212> PRT
<213> Mus musculus
<400> 77
Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln
1 5 10 15
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr
20 25 30
Ala Ile Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu
35 40 45
Gly Val Ile Trp Thr Gly Gly Gly Thr Asn Tyr Asn Ser Ala Leu Lys
50 55 60
Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu
65 70 75 80
Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg Tyr Tyr Cys Ala
85 90 95
Arg Lys Asp Tyr Tyr Tyr Gly Ser Ser Tyr Ala Met Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 78
<211> 121
<212> PRT
<213> Mus musculus
<400> 78
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asp Tyr
20 25 30
Tyr Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Ala Arg Ile Tyr Pro Gly Ser Gly Asn Thr Tyr Tyr Asn Glu Lys Phe
50 55 60
Thr Gly Lys Ala Thr Leu Thr Ala Glu Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95
Ala Arg Asp Tyr Gly Ser Ser Tyr Val Asp Tyr Phe Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Thr Leu Thr Val Ser Ser
115 120
<210> 79
<211> 121
<212> PRT
<213> Mus musculus
<400> 79
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Asp
20 25 30
Tyr Met His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile
35 40 45
Gly Trp Ile Asn Pro Glu Asn Gly Asp Thr Glu Tyr Ala Ser Lys Phe
50 55 60
Gln Gly Lys Ala Ala Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Cys
65 70 75 80
Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ser Thr Gly Gly Tyr Gly Asn Tyr Val Asp Ala Met Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 80
<211> 121
<212> PRT
<213> Mus musculus
<400> 80
Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln
1 5 10 15
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr
20 25 30
Ala Ile Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu
35 40 45
Gly Val Ile Trp Thr Gly Gly Gly Thr Asn Tyr Asn Ser Ala Leu Lys
50 55 60
Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu
65 70 75 80
Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg Tyr Tyr Cys Ala
85 90 95
Arg Lys Asp Tyr Tyr Gly Ser Ser Ser Asn Val Met Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 81
<211> 120
<212> PRT
<213> Mus musculus
<400> 81
Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln
1 5 10 15
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr
20 25 30
Ala Ile Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu
35 40 45
Gly Val Ile Trp Thr Gly Gly Gly Thr Asn Tyr Asn Ser Ala Leu Arg
50 55 60
Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu
65 70 75 80
Lys Met Asn Ser Leu His Thr Asp Asp Thr Ala Arg Tyr Tyr Cys Ala
85 90 95
Arg Lys Asp Tyr Tyr Gly Ser Ser Leu Ala Met Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 82
<211> 121
<212> PRT
<213> Mus musculus
<400> 82
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr
20 25 30
Tyr Met Asn Trp Val Lys Gln Ser Pro Glu Lys Ser Leu Glu Trp Ile
35 40 45
Gly Glu Ile Asn Pro Ser Thr Gly Gly Pro Thr Tyr Asn Gln Lys Phe
50 55 60
Lys Ala Lys Ala Thr Val Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Arg Asn Tyr Asp Leu Tyr Tyr Tyr Ala Met Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 83
<211> 124
<212> PRT
<213> Mus musculus
<400> 83
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr
20 25 30
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Tyr Ile Asn Pro Ser Ser Gly Tyr Thr Lys Phe Asn Gln Lys Phe
50 55 60
Asn Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Thr Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Pro Thr Tyr Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ser Asp Tyr Tyr Gly Ser Ser Tyr Val Gly Tyr Ala Met Asp
100 105 110
Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 84
<211> 121
<212> PRT
<213> Mus musculus
<400> 84
Glu Val Gln Leu Gln Gln Pro Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr
20 25 30
Tyr Met Asn Trp Val Lys Gln Ser Pro Glu Lys Ser Leu Glu Trp Ile
35 40 45
Gly Glu Ile Asn Pro Ser Thr Gly Gly Thr Ser Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Arg Asn Tyr Asp Leu Tyr Tyr Tyr Ala Met Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 85
<211> 121
<212> PRT
<213> Mus musculus
<400> 85
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Asp
20 25 30
Tyr Met His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile
35 40 45
Gly Trp Ile Asn Pro Glu Asn Gly Asp Thr Glu Tyr Ala Ser Lys Phe
50 55 60
Gln Gly Lys Ala Ala Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Cys
65 70 75 80
Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ser Thr Gly Gly Tyr Gly Asn Tyr Val Asp Ala Met Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 86
<211> 121
<212> PRT
<213> Mus musculus
<400> 86
Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln
1 5 10 15
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr
20 25 30
Ala Ile Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu
35 40 45
Gly Val Ile Trp Thr Gly Gly Gly Thr Asn Tyr Asn Ser Ala Leu Lys
50 55 60
Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu
65 70 75 80
Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg Tyr Tyr Cys Ala
85 90 95
Arg Lys Asp Tyr Tyr Gly Ser Ser Ser Asn Val Met Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 87
<211> 121
<212> PRT
<213> Mus musculus
<400> 87
Glu Val Gln Leu Gln Gln Pro Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr
20 25 30
Tyr Met Asn Trp Val Lys Gln Ser Pro Glu Lys Ser Leu Glu Trp Ile
35 40 45
Gly Glu Ile Asn Pro Ser Thr Gly Gly Thr Ser Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ser Arg Arg Asn Tyr Asp Leu Tyr Tyr Tyr Ala Met Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 88
<211> 114
<212> PRT
<213> Mus musculus
<400> 88
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr
20 25 30
Ser Met Asn Trp Val Lys Lys Ser Pro Glu Lys Ser Leu Glu Trp Ile
35 40 45
Gly Glu Ile Asn Pro Ser Thr Gly Gly Thr Thr Tyr Asn Gln Lys Phe
50 55 60
Lys Ala Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Ile Gln Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Ala Gly Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val
100 105 110
Ser Ala
<210> 89
<211> 118
<212> PRT
<213> Mus musculus
<400> 89
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Ser
20 25 30
Trp Met Asn Trp Val Lys Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile
35 40 45
Gly Arg Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95
Ala Arg Asp His Gly Pro Ala Trp Phe Ala Tyr Arg Gly Gln Gly Thr
100 105 110
Leu Val Thr Val Ser Ala
115
<210> 90
<211> 114
<212> PRT
<213> Mus musculus
<400> 90
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr
20 25 30
Ser Met Asn Trp Val Lys Lys Ser Pro Glu Lys Ser Leu Glu Trp Ile
35 40 45
Gly Glu Ile Asn Pro Ser Thr Gly Gly Thr Thr Tyr Asn Gln Lys Phe
50 55 60
Lys Ala Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Ile Gln Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Ala Gly Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val
100 105 110
Ser Ala
<210> 91
<211> 119
<212> PRT
<213> Mus musculus
<400> 91
Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln
1 5 10 15
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr
20 25 30
Ala Ile Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu
35 40 45
Gly Val Ile Trp Thr Gly Gly Gly Thr Asn Tyr Asn Ser Ala Leu Lys
50 55 60
Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu
65 70 75 80
Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg Tyr Tyr Cys Ala
85 90 95
Arg Ile Ser Tyr Tyr Asp Tyr Glu Gly Val Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Thr Leu Thr Val Ser Ser
115
<210> 92
<211> 127
<212> PRT
<213> Mus musculus
<400> 92
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val
35 40 45
Ser Ala Ile Ser Gly Asn Gly Gly Ser Thr Tyr Tyr Ala Lys Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Gly Ser Leu Arg Ala Glu Asp Met Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Ala Glu Tyr Tyr Asp Phe Trp Ser Gly Tyr Tyr Ser Ala
100 105 110
Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 93
<211> 120
<212> PRT
<213> Mus musculus
<400> 93
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Ala Pro Ser Gln
1 5 10 15
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Ile Asn Tyr
20 25 30
Ala Ile Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu
35 40 45
Gly Val Ile Trp Thr Gly Gly Gly Thr Asn Tyr Asn Ser Ala Leu Lys
50 55 60
Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu
65 70 75 80
Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg Tyr Tyr Cys Ala
85 90 95
Arg Lys Asp Tyr Tyr Gly Arg Tyr Tyr Gly Met Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 94
<211> 118
<212> PRT
<213> Mus musculus
<400> 94
Glu Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Asn Tyr
20 25 30
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Arg Ile His Pro Ser Asp Ser Asp Thr Lys Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Ile Leu Asp Ser Tyr Trp Tyr Phe Asp Val Trp Gly Thr Gly Thr
100 105 110
Thr Val Thr Val Ser Ser
115
<210> 95
<211> 119
<212> PRT
<213> Mus musculus
<400> 95
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Ser
20 25 30
Trp Met Asn Trp Val Lys Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile
35 40 45
Gly Arg Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Leu
50 55 60
Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95
Ala Arg Lys Ser Tyr Gly Tyr Trp His Phe Asp Val Trp Gly Thr Gly
100 105 110
Thr Thr Val Thr Val Ser Ser
115
<210> 96
<211> 114
<212> PRT
<213> Mus musculus
<400> 96
Glu Val Gln Leu Gln Gln Pro Gly Pro Glu Leu Val Lys Pro Gly Thr
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
35 40 45
Gly Asp Ile Asn Pro Asn Asn Gly Gly Thr Asn Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Cys Tyr Cys
85 90 95
Ala Ala Gly Lys Gly Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val
100 105 110
Ser Ser
<210> 97
<211> 118
<212> PRT
<213> Mus musculus
<400> 97
Glu Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Asn Tyr
20 25 30
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Arg Ile His Pro Ser Asp Ser Asp Thr Lys Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Ile Leu Asp Ser Tyr Trp Tyr Phe Asp Val Trp Gly Thr Gly Thr
100 105 110
Thr Val Thr Val Ser Ser
115
<210> 98
<211> 114
<212> PRT
<213> Mus musculus
<400> 98
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Thr
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
35 40 45
Gly Asp Ile Asn Pro Asn Asn Gly Gly Thr Asn Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Ala Gly Lys Gly Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val
100 105 110
Ser Ser
<210> 99
<211> 120
<212> PRT
<213> Mus musculus
<400> 99
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
35 40 45
Gly Asp Ile Asn Pro Asn Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Lys Gly Asp Gly Tyr Tyr Gly Gly Phe Ala Tyr Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ala
115 120
<210> 100
<211> 122
<212> PRT
<213> Mus musculus
<400> 100
Glu Val Gln Leu Gln Gln Ser Val Ala Asp Leu Val Arg Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asn Thr
20 25 30
Tyr Met His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile
35 40 45
Gly Arg Ile Asp Pro Thr Asn Gly Asp Thr Lys Tyr Val Ser Lys Phe
50 55 60
Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr
65 70 75 80
Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Ile Tyr Tyr Cys
85 90 95
Ala Thr Tyr Gly Ser Tyr Tyr Leu Tyr Tyr Tyr Ala Met Asn Tyr Trp
100 105 110
Gly Gln Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 101
<211> 121
<212> PRT
<213> Mus musculus
<400> 101
Glu Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Tyr Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Ala Arg Ile Tyr Pro Gly Thr Gly Thr Thr Tyr Tyr Asn Glu Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Ala Glu Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95
Ala Arg Tyr Asp Gly Asn Leu Tyr Tyr Tyr Ala Met Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 102
<211> 120
<212> PRT
<213> Mus musculus
<400> 102
Glu Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Trp Ile Thr Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Asp Ile Tyr Pro Gly Ser Gly Ser Thr Lys Tyr Asn Glu Lys Phe
50 55 60
Arg Ser Glu Ala Thr Leu Thr Val Asp Thr Ser Ser Thr Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Trp Asp Phe Tyr Gly Ser Arg Thr Phe Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Thr Leu Thr Val Ser Ser
115 120
<210> 103
<211> 120
<212> PRT
<213> Mus musculus
<400> 103
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Trp Ile Thr Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Asp Ile Tyr Pro Gly Ser Gly Ser Thr Lys Tyr Asn Glu Lys Phe
50 55 60
Arg Ser Glu Ala Thr Leu Thr Val Asp Thr Ser Ser Thr Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Trp Asp Phe Tyr Gly Ser Arg Thr Phe Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Thr Leu Thr Val Ser Ser
115 120
<210> 104
<211> 118
<212> PRT
<213> Homo sapiens
<400> 104
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn
20 25 30
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Ala Thr Trp Leu Arg Gly Val Met Asp Val Trp Gly Gln Gly Thr
100 105 110
Thr Val Thr Val Ser Ser
115
<210> 105
<211> 126
<212> PRT
<213> Homo sapiens
<400> 105
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Val Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Gly Ile Asn Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Lys Asp Val Arg Tyr Cys Ser Ser Thr Ser Cys Tyr Phe Ser Ala
100 105 110
Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120 125
<210> 106
<211> 120
<212> PRT
<213> Homo sapiens
<400> 106
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Gly Gly Ser Tyr Tyr Tyr Trp Phe Asp Pro Trp Gly Gln
100 105 110
Gly Thr Met Val Thr Val Ser Ser
115 120
<210> 107
<211> 123
<212> PRT
<213> Homo sapiens
<400> 107
Glu Val Gln Leu Val Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr
20 25 30
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
35 40 45
Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys
50 55 60
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
65 70 75 80
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Ala Gly Tyr Ser Ser Ser Trp Tyr Gly Val Arg Gly Val Asp Pro
100 105 110
Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120
<210> 108
<211> 124
<212> PRT
<213> Homo sapiens
<400> 108
Gln Val Gln Leu Leu Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr
20 25 30
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Ser Asp Ile Val Val Val Pro Val Gly Asn Trp Phe Asp
100 105 110
Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 109
<211> 128
<212> PRT
<213> Homo sapiens
<400> 109
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Ala Cys Thr Val Ser Gly Gly Ser Val Ser Ser Asp
20 25 30
Asn Ser Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu
35 40 45
Trp Ile Gly Tyr Thr Phe His Ser Gly Ser Ala Asn Tyr Asn Pro Ser
50 55 60
Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe
65 70 75 80
Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
85 90 95
Cys Ala Arg Val Gln Arg Tyr Tyr Pro Asp Ser Ser Gly Phe Tyr Gly
100 105 110
Arg Arg Phe Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 110
<211> 121
<212> PRT
<213> Homo sapiens
<400> 110
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr
20 25 30
Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Val Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ser Gly Gly Gly Ser Tyr Arg Gly Pro Phe Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 111
<211> 124
<212> PRT
<213> Homo sapiens
<400> 111
Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser
20 25 30
Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu
35 40 45
Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser
50 55 60
Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe
65 70 75 80
Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
85 90 95
Ser Ala Arg Gly Asp Arg Ile Gln Leu Trp Leu Leu Asp Ala Phe Asp
100 105 110
Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120
<210> 112
<211> 124
<212> PRT
<213> Homo sapiens
<400> 112
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Ile Gly Leu Gly Leu Gly Gly Leu Leu Arg Arg Tyr Phe Asp
100 105 110
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 113
<211> 122
<212> PRT
<213> Homo sapiens
<400> 113
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Leu Lys Pro Gly Glu
1 5 10 15
Thr Leu Ser Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr
20 25 30
Tyr Trp Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
35 40 45
Ala Val Ile Asn His Ser Gly Ser Thr Ile Tyr Tyr Pro Tyr Pro Val
50 55 60
Lys Gly Val Phe Ile Phe Ser Arg Asp Thr Ala Asn Asn Phe Ser Leu
65 70 75 80
Lys Leu Met Asn Met Met Thr Ser Asp Thr Ala Val Tyr Tyr Cys Gly
85 90 95
Thr Arg Ile Met Ile Thr Trp Tyr Ser Arg Arg Gly Met Asp Gly Trp
100 105 110
Gly Lys Gly Val Thr Val Thr Val Ser Ser
115 120
<210> 114
<211> 132
<212> PRT
<213> Homo sapiens
<400> 114
Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Val Ile Asn Pro Ser Gly Gly Ser Thr Thr Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Val Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu Arg Gly Asp Ser Ser Gly Tyr Tyr Glu Ile Ile Thr Thr
100 105 110
Ala Asn Arg Arg Phe Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val
115 120 125
Thr Val Ser Ser
130
<210> 115
<211> 124
<212> PRT
<213> Homo sapiens
<400> 115
Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Phe
20 25 30
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile Ile Pro Ile Phe Asp Thr Thr Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Arg Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ile Pro Gly Trp Asp Arg Gly Thr Asp Arg Asn Trp Asn Asp
100 105 110
Asp Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 116
<211> 122
<212> PRT
<213> Homo sapiens
<400> 116
Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr
20 25 30
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Val Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Thr Tyr Ser Phe Asp Ser Ser Gly Tyr Tyr Tyr Asp Tyr Trp
100 105 110
Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120
<210> 117
<211> 124
<212> PRT
<213> Homo sapiens
<400> 117
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Leu Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Phe
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Asp Glu Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Arg Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ala Phe Tyr Asp Ser Asn Trp Ser Val Gly Ser Tyr Phe Asp
100 105 110
Ser Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser
115 120
<210> 118
<211> 125
<212> PRT
<213> Homo sapiens
<400> 118
Glu Val Gln Leu Leu Gln Ser Gly Gly Asp Leu Ile Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Glu Asp Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val
35 40 45
Ser Gly Ile Ser Tyr Asn Gly Gly Ser Ile Asp Tyr Val Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ala Leu Tyr
65 70 75 80
Leu Glu Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Phe Tyr Tyr Cys
85 90 95
Ala Lys Asp Ser Val Arg Arg Glu Tyr Thr His Ala Arg Val Pro Phe
100 105 110
Asp Asn Trp Gly Leu Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 119
<211> 124
<212> PRT
<213> Homo sapiens
<400> 119
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Asn Phe Asn Asn Tyr
20 25 30
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu
35 40 45
Ala Ala Leu Ser Tyr Glu Gly Ser Lys Glu His Tyr Ala Asp Ser Leu
50 55 60
Lys Gly Arg Phe Thr Val Ser Arg Asp Tyr Ser Arg Ala Thr Leu His
65 70 75 80
Leu His Met Asn Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Phe Cys
85 90 95
Ala Lys Ser Ser Lys Ile Phe Tyr Leu Gly Glu Ser Arg Glu Val Asp
100 105 110
Tyr Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 120
<211> 128
<212> PRT
<213> Homo sapiens
<400> 120
Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Thr Glu Leu
20 25 30
Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met
35 40 45
Gly Gly Phe Asp Pro Glu Asp Gly Glu Thr Met Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Thr Ser Thr Ala Val Ala Gly Thr Pro Asp Leu Phe Asp Tyr Tyr
100 105 110
Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 121
<211> 126
<212> PRT
<213> Homo sapiens
<400> 121
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Val Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Trp Asp Tyr Asp Ile Leu Thr Gly Ser Trp Phe Gly Ala
100 105 110
Phe Asp Ile Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 122
<211> 120
<212> PRT
<213> Homo sapiens
<400> 122
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Asn Ile Gln Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Pro Thr Ile Gly Tyr Ser Tyr Gly Ser Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 123
<211> 125
<212> PRT
<213> Homo sapiens
<400> 123
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Val Val Ser Gly Phe Thr Phe Asn Asn Tyr
20 25 30
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Glu Gly Ser Val Lys Tyr Tyr Gly Asp His Val
50 55 60
Asp Gly Arg Phe Thr Ile Ser Arg Asp Pro Phe Lys Asn Thr Leu Tyr
65 70 75 80
Leu His Met Asn Asn Leu Arg Pro Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val Ser Ala Ile Phe Trp Leu Gly Gln Gly Leu Ser Pro Ile
100 105 110
Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 124
<211> 115
<212> PRT
<213> Homo sapiens
<400> 124
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Val Ser Ser Asn
20 25 30
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg His Asn Ser Lys Asn Thr Leu Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Glu Ala Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr
100 105 110
Val Ser Ser
115
<210> 125
<211> 118
<212> PRT
<213> Homo sapiens
<400> 125
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Val Ser Ser Asn
20 25 30
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Val Ile Tyr Ser Gly Gly Ser Thr Asp Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Lys Ser Lys Asn Thr Leu Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Asp Leu Gly Glu Ala Gly Gly Met Asp Val Trp Gly Gln Gly Thr
100 105 110
Thr Val Thr Val Ser Ser
115
<210> 126
<211> 117
<212> PRT
<213> Homo sapiens
<400> 126
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Ile Val Ser Ser Asn
20 25 30
Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
65 70 75 80
Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Asp Leu Gly Pro Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr
100 105 110
Val Thr Val Ser Ser
115
<210> 127
<211> 117
<212> PRT
<213> Homo sapiens
<400> 127
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Phe Ile Val Ser Arg Asn
20 25 30
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Asn Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Asp Tyr Gly Asp Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu
100 105 110
Val Thr Val Ser Ser
115
<210> 128
<211> 126
<212> PRT
<213> Homo sapiens
<400> 128
Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Ile Asn Thr Asn Thr Gly Asn Pro Thr Tyr Ala Gln Gly Phe
50 55 60
Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr
65 70 75 80
Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Pro Gln Gly Gly Ser Ser Trp Tyr Arg Asp Tyr Tyr Tyr Gly
100 105 110
Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 129
<211> 124
<212> PRT
<213> Homo sapiens
<400> 129
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile Tyr
20 25 30
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Gly Arg Pro Ser Asp Ile Val Val Val Val Ala Phe Asp
100 105 110
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 130
<211> 117
<212> PRT
<213> Homo sapiens
<400> 130
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn
20 25 30
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Ala Gly Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Asp Tyr Gly Asp Phe Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu
100 105 110
Val Thr Val Ser Ser
115
<210> 131
<211> 128
<212> PRT
<213> Homo sapiens
<400> 131
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr
20 25 30
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Ile Asn Pro Ile Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ser Pro Ala Ser Arg Gly Tyr Ser Gly Tyr Asp His Gly Tyr Tyr
100 105 110
Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 132
<211> 123
<212> PRT
<213> Homo sapiens
<400> 132
Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Thr
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Ser Ser
20 25 30
Ala Val Gln Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Ile
35 40 45
Gly Trp Ile Val Val Gly Ser Gly Asn Thr Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Glu Arg Val Thr Ile Thr Arg Asp Met Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ala Pro His Cys Ser Gly Gly Ser Cys Leu Asp Ala Phe Asp Ile
100 105 110
Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120
<210> 133
<211> 125
<212> PRT
<213> Homo sapiens
<400> 133
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asp Tyr
20 25 30
Cys Met Ser Trp Ile Arg Arg Ala Pro Gly Lys Gly Leu Glu Trp Leu
35 40 45
Ser Tyr Ile Ser Asn Ser Gly Thr Thr Arg Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Gly Arg Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asp Ser Leu Ser Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Arg Gly Asp Gly Ser Ser Ser Ile Tyr Tyr Tyr Asn Tyr Met
100 105 110
Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 134
<211> 120
<212> PRT
<213> Homo sapiens
<400> 134
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Thr Val Ile Ser Tyr Asp Gly Arg Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu Phe Gly Asp Pro Glu Trp Tyr Phe Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 135
<211> 122
<212> PRT
<213> Homo sapiens
<400> 135
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Met Ala Ser Gly Tyr Thr Phe Thr Gly Tyr
20 25 30
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Ser Pro Phe Ser Ala Leu Gly Ala Ser Asn Asp Tyr Trp
100 105 110
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 136
<211> 123
<212> PRT
<213> Homo sapiens
<400> 136
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Ala Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Leu Tyr Asp Gly Ser Gly Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Gly Ile Val Asp Thr Ala Leu Val Thr Trp Phe Asp Tyr
100 105 110
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 137
<211> 138
<212> PRT
<213> Homo sapiens
<400> 137
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr
20 25 30
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Asn Arg Leu Leu Tyr Cys Ser Ser Thr Ser Cys Tyr Leu
100 105 110
Asp Ala Val Arg Gln Gly Tyr Tyr Tyr Tyr Tyr Tyr Met Asp Val Trp
115 120 125
Gly Lys Gly Thr Thr Val Thr Val Ser Ser
130 135
<210> 138
<211> 127
<212> PRT
<213> Homo sapiens
<400> 138
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr
20 25 30
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val Thr Ala Pro Tyr Cys Ser Gly Gly Ser Cys Tyr Gly Gly
100 105 110
Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 139
<211> 126
<212> PRT
<213> Homo sapiens
<400> 139
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Gly Ile Ser Trp Asn Ser Gly Thr Ile Gly Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Phe Tyr Tyr Cys
85 90 95
Ala Lys Ala Gly Val Arg Gly Ile Ala Ala Ala Gly Pro Asp Leu Asn
100 105 110
Phe Asp His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 140
<211> 121
<212> PRT
<213> Homo sapiens
<400> 140
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr
20 25 30
Ala Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Phe Asp Asp Ser Ser Phe Trp Ala Phe Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 141
<211> 120
<212> PRT
<213> Homo sapiens
<400> 141
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Val Pro Arg Glu Gly Thr Pro Gly Phe Asp Pro Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 142
<211> 123
<212> PRT
<213> Homo sapiens
<400> 142
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly
20 25 30
Gly Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu
35 40 45
Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser
50 55 60
Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe
65 70 75 80
Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
85 90 95
Cys Ala Arg Val Trp Gln Tyr Tyr Asp Ser Ser Gly Ser Phe Asp Tyr
100 105 110
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 143
<211> 129
<212> PRT
<213> Homo sapiens
<400> 143
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Val Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser
20 25 30
Arg Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu
35 40 45
Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser
50 55 60
Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe
65 70 75 80
Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
85 90 95
Cys Ala Arg His Ala Ala Ala Tyr Tyr Asp Arg Ser Gly Tyr Tyr Phe
100 105 110
Ile Glu Tyr Phe Gln His Trp Gly Gln Gly Thr Leu Val Thr Val Ser
115 120 125
Ser
<210> 144
<211> 127
<212> PRT
<213> Homo sapiens
<400> 144
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Ala Ser Gly Ile Tyr Cys Ser Gly Gly Asp Cys Tyr Ser Tyr
100 105 110
Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 145
<211> 123
<212> PRT
<213> Homo sapiens
<400> 145
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly
20 25 30
Gly Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu
35 40 45
Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser
50 55 60
Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe
65 70 75 80
Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
85 90 95
Cys Ala Arg Thr Met Tyr Tyr Tyr Asp Ser Ser Gly Ser Phe Asp Tyr
100 105 110
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 146
<211> 127
<212> PRT
<213> Homo sapiens
<400> 146
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Ala Ser Gly Ile Tyr Cys Ser Gly Gly Asn Cys Tyr Ser Tyr
100 105 110
Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 147
<211> 123
<212> PRT
<213> Homo sapiens
<400> 147
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Asp Met His Trp Val Arg Gln Ala Thr Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Gly Thr Ala Gly Asp Thr Tyr Tyr Pro Gly Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Ser Leu Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Ala Gly Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Val Gly Tyr Asp Ser Ser Gly Tyr Ser Gly Trp Tyr Phe Asp Leu
100 105 110
Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 148
<211> 117
<212> PRT
<213> Homo sapiens
<400> 148
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Val Ser Ser Asn
20 25 30
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Thr Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Val
85 90 95
Arg Asp Tyr Gly Asp Phe Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu
100 105 110
Val Thr Val Ser Ser
115
<210> 149
<211> 117
<212> PRT
<213> Homo sapiens
<400> 149
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Val Ser Ser Asn
20 25 30
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Asp Tyr Gly Asp Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu
100 105 110
Val Thr Val Ser Ser
115
<210> 150
<211> 123
<212> PRT
<213> Homo sapiens
<400> 150
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Leu Ser Gly Phe
20 25 30
Tyr Trp Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
35 40 45
Gly Glu Thr Asn His Phe Gly Ser Thr Gly Tyr Lys Pro Ser Leu Lys
50 55 60
Ser Arg Val Thr Ile Ser Val Asp Met Ser Arg Asn Gln Phe Ser Leu
65 70 75 80
Lys Val Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Lys Pro Leu Leu Tyr Ser Asp Phe Ser Pro Gly Ala Phe Asp Ile
100 105 110
Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120
<210> 151
<211> 123
<212> PRT
<213> Homo sapiens
<400> 151
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Ser Cys Ala Val Tyr Gly Gly Ser Leu Ser Gly Tyr
20 25 30
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
35 40 45
Gly Glu Ile Asn His Phe Gly Ser Thr Gly Tyr Asn Pro Ser Leu Lys
50 55 60
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Phe Ser Val
65 70 75 80
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Lys Pro Leu Leu Tyr Ser Asn Leu Ser Pro Gly Ala Phe Asp Ile
100 105 110
Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120
<210> 152
<211> 118
<212> PRT
<213> Homo sapiens
<400> 152
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn
20 25 30
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Gly Glu Gly Trp Glu Leu Pro Tyr Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Leu Val Thr Val Ser Ser
115
<210> 153
<211> 132
<212> PRT
<213> Homo sapiens
<400> 153
Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala Ser Val Ser Ser Gly
20 25 30
Ser Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu
35 40 45
Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser
50 55 60
Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe
65 70 75 80
Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
85 90 95
Cys Ala Arg Glu Arg Pro Gly Gly Thr Tyr Ser Asn Thr Trp Tyr Thr
100 105 110
Pro Thr Asp Thr Asn Trp Phe Asp Thr Trp Gly Gln Gly Thr Leu Val
115 120 125
Thr Val Ser Ser
130
<210> 154
<211> 122
<212> PRT
<213> Homo sapiens
<400> 154
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Arg Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Gly Phe Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Phe Ala Gln Lys Leu
50 55 60
Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Glu Ala Val Ala Gly Thr Thr Gly Phe Phe Asp Tyr Trp
100 105 110
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 155
<211> 120
<212> PRT
<213> Homo sapiens
<400> 155
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly
1 5 10 15
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Thr
20 25 30
Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp
35 40 45
Ile Gly Glu Ile Tyr His Thr Gly Ser Thr Asn Tyr Asn Pro Ser Leu
50 55 60
Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser
65 70 75 80
Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Val Arg Asp Gly Gly Arg Pro Gly Asp Ala Phe Asp Ile Trp Gly Gln
100 105 110
Gly Thr Met Val Thr Val Ser Ser
115 120
<210> 156
<211> 119
<212> PRT
<213> Homo sapiens
<400> 156
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Gly Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu His Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ile Gln Leu Trp Leu Arg Gly Gly Tyr Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 157
<211> 128
<212> PRT
<213> Homo sapiens
<400> 157
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr
20 25 30
Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
35 40 45
Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe
50 55 60
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65 70 75 80
Met Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
85 90 95
Ala Arg Ser Phe Arg Asp Asp Pro Arg Ile Ala Val Ala Gly Pro Ala
100 105 110
Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120 125
<210> 158
<211> 127
<212> PRT
<213> Homo sapiens
<400> 158
Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr
20 25 30
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
35 40 45
Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys
50 55 60
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
65 70 75 80
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Val Glu Asp Trp Gly Tyr Cys Ser Ser Thr Asn Cys Tyr Ser Gly
100 105 110
Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120 125
<210> 159
<211> 121
<212> PRT
<213> Homo sapiens
<400> 159
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser His
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu Asp Tyr Tyr Asp Ser Ser Gly Ser Phe Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 160
<211> 125
<212> PRT
<213> Homo sapiens
<400> 160
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe
20 25 30
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Val Asn Pro Asp Asp Ile Leu Thr Gly Val Asp Ala Phe
100 105 110
Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120 125
<210> 161
<211> 117
<212> PRT
<213> Homo sapiens
<400> 161
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly
1 5 10 15
Ser Leu Lys Leu Ser Cys Val Val Ser Gly Phe Thr Val Ser Lys Asn
20 25 30
Tyr Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Val Ile Phe Ala Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Ala Ile Ser Arg Asp Asn Ser Asn Asn Thr Leu Phe Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Ile Tyr Tyr Cys Ala
85 90 95
Arg Gly Asp Gly Glu Leu Phe Phe Asp Gln Trp Gly Gln Gly Thr Leu
100 105 110
Val Thr Val Ser Ser
115
<210> 162
<211> 120
<212> PRT
<213> Homo sapiens
<400> 162
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Lys Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr
20 25 30
Ala Met Thr Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Gly Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Gly Tyr Ala Ala
50 55 60
Ser Val Lys Tyr Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile
65 70 75 80
Ala Tyr Leu Gln Met Asp Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
85 90 95
Tyr Cys Thr Arg Trp Asp Gly Trp Ser Gln His Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 163
<211> 118
<212> PRT
<213> Homo sapiens
<400> 163
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Tyr Ser Thr Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Phe Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Phe Tyr His Asn Trp Phe Asp Pro Trp Gly Gln Gly Thr
100 105 110
Leu Val Thr Val Ser Ser
115
<210> 164
<211> 127
<212> PRT
<213> Homo sapiens
<400> 164
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Glu Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Ser Asn Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Pro Ile Trp Phe Gly Glu Leu Leu Ser Pro Pro Phe Val
100 105 110
His Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 165
<211> 127
<212> PRT
<213> Homo sapiens
<400> 165
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys
85 90 95
Ala Ser Gly Tyr Thr Gly Tyr Asp Tyr Phe Val Arg Gly Asp Tyr Tyr
100 105 110
Gly Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 166
<211> 127
<212> PRT
<213> Homo sapiens
<400> 166
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Leu
50 55 60
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ala Asn His Glu Thr Thr Met Asp Thr Tyr Tyr Tyr Tyr Tyr
100 105 110
Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 167
<211> 118
<212> PRT
<213> Homo sapiens
<400> 167
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn
20 25 30
Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Leu Ile Tyr Pro Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Glu Gly Met Gly Met Ala Ala Ala Gly Thr Trp Gly Gln Gly Thr
100 105 110
Leu Val Thr Val Ser Ser
115
<210> 168
<211> 129
<212> PRT
<213> Homo sapiens
<400> 168
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr
20 25 30
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Ile Ser Pro Val Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ala Pro Leu Phe Pro Thr Gly Val Leu Ala Gly Asp Tyr Tyr
100 105 110
Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser
115 120 125
Ser
<210> 169
<211> 119
<212> PRT
<213> Homo sapiens
<400> 169
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Val Ser Ser Asn
20 25 30
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Val Leu Tyr Ser Gly Gly Ser Ser Phe Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Glu Ser Gly Asp Thr Thr Met Ala Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 170
<211> 116
<212> PRT
<213> Homo sapiens
<400> 170
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Val Thr Val Ser Arg Asn
20 25 30
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Asp Leu Ser Ala Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val
100 105 110
Thr Val Ser Ser
115
<210> 171
<211> 125
<212> PRT
<213> Homo sapiens
<400> 171
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr
20 25 30
Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val
35 40 45
Ser Tyr Ile Ser Arg Ser Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu Gly Ala Arg Val Gly Ala Thr Tyr Asp Thr Tyr Tyr Phe
100 105 110
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 172
<211> 123
<212> PRT
<213> Homo sapiens
<400> 172
Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Thr
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Ser Ser
20 25 30
Ala Val Gln Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Ile
35 40 45
Gly Trp Ile Val Val Gly Ser Gly Asn Thr Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Glu Arg Val Thr Ile Thr Arg Asp Met Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ala Pro Tyr Cys Ser Gly Gly Ser Cys Ser Asp Ala Phe Asp Ile
100 105 110
Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120
<210> 173
<211> 118
<212> PRT
<213> Homo sapiens
<400> 173
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Ser Cys Ala Val Ser Gly Gly Ser Ile Gly Ser Tyr
20 25 30
Phe Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
35 40 45
Gly Tyr Leu His Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys
50 55 60
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
65 70 75 80
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Leu Gln Trp Leu Arg Gly Ala Phe Asp Ile Trp Gly Gln Gly Thr
100 105 110
Met Val Thr Val Ser Ser
115
<210> 174
<211> 125
<212> PRT
<213> Homo sapiens
<400> 174
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr
20 25 30
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Thr Ala His Pro Arg Arg Ile Gln Gly Val Phe Phe Leu Gly Pro
100 105 110
Gly Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 175
<211> 125
<212> PRT
<213> Homo sapiens
<400> 175
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr
20 25 30
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Thr Ile Thr Gly Ser Gly Arg Asp Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe
65 70 75 80
Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Ala Ala Val Tyr Ser Cys
85 90 95
Ala Asn His Pro Leu Ala Ser Gly Asp Asp Tyr Tyr His Tyr Tyr Met
100 105 110
Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 176
<211> 120
<212> PRT
<213> Homo sapiens
<400> 176
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr
20 25 30
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Gly Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ser Arg Pro Thr Pro Asp Trp Tyr Phe Asp Leu Trp Gly Arg
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 177
<211> 122
<212> PRT
<213> Homo sapiens
<400> 177
Gln Val Gln Leu Val Gln Ser Gly Ser Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr
20 25 30
Ala Phe Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Arg Ile Ile Pro Ile Leu Ala Leu Ala Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Val Asn Gln Ala Val Thr Thr Pro Phe Ser Met Asp Val Trp
100 105 110
Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 178
<211> 122
<212> PRT
<213> Homo sapiens
<400> 178
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly
1 5 10 15
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Asn
20 25 30
Asn Trp Trp Ser Cys Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp
35 40 45
Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu
50 55 60
Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser
65 70 75 80
Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Gly Asp Thr Ala Met Gly Pro Glu Tyr Phe Asp Tyr Trp
100 105 110
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 179
<211> 123
<212> PRT
<213> Homo sapiens
<400> 179
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Leu Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Ser Asp Val Asp Thr Ser Met Val Thr Trp Phe Asp Tyr
100 105 110
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 180
<211> 123
<212> PRT
<213> Homo sapiens
<400> 180
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr
20 25 30
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Gly Ser Asp Gly Ser Thr Tyr Tyr Ala Gly Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Asp Pro Leu Ile Thr Gly Pro Thr Tyr Gln Tyr Phe His Tyr
100 105 110
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 181
<211> 119
<212> PRT
<213> Homo sapiens
<400> 181
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Pro Phe Asp Gly Arg Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ser Ser Ser Gly Tyr Leu Phe His Ser Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 182
<211> 119
<212> PRT
<213> Homo sapiens
<400> 182
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr
20 25 30
Trp Met Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Gly Gly Thr Trp Leu Arg Ser Ser Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 183
<211> 121
<212> PRT
<213> Homo sapiens
<400> 183
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Ser Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Gly Ala Tyr Ser Tyr Tyr Tyr Tyr Met Asp Val Trp Gly
100 105 110
Lys Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 184
<211> 117
<212> PRT
<213> Homo sapiens
<400> 184
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Val Thr Val Ser Ser Asn
20 25 30
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Leu Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Glu Asn Thr Leu Tyr Leu
65 70 75 80
Gln Met Asn Thr Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Asp Leu Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr
100 105 110
Val Thr Val Ser Ser
115
<210> 185
<211> 124
<212> PRT
<213> Homo sapiens
<400> 185
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Ala Met Phe Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ala Asp Leu Gly Tyr Cys Thr Asn Gly Val Cys Tyr Val Asp
100 105 110
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 186
<211> 129
<212> PRT
<213> Homo sapiens
<400> 186
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Val Ser Thr Lys
20 25 30
Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Val Leu Tyr Ser Gly Gly Ser Asp Tyr Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ala Leu Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Val Glu Asp Thr Gly Val Tyr Tyr Cys Ala
85 90 95
Arg Asp Ser Ser Glu Val Arg Asp His Pro Gly His Pro Gly Arg Ser
100 105 110
Val Gly Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser
115 120 125
Ser
<210> 187
<211> 131
<212> PRT
<213> Homo sapiens
<400> 187
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asn Asn
20 25 30
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Lys Ser Lys Asn Thr Leu Tyr Leu
65 70 75 80
Gln Met Asn Arg Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Glu Gly Glu Val Glu Gly Tyr Asn Asp Phe Trp Ser Gly Tyr Ser
100 105 110
Arg Asp Arg Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr
115 120 125
Val Ser Ser
130
<210> 188
<211> 131
<212> PRT
<213> Homo sapiens
<400> 188
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Val Ser Ser Asn
20 25 30
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Glu Gly Glu Val Glu Gly Tyr Tyr Asp Phe Trp Ser Gly Tyr Ser
100 105 110
Arg Asp Arg Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr
115 120 125
Val Ser Ser
130
<210> 189
<211> 120
<212> PRT
<213> Homo sapiens
<400> 189
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Thr Ala Tyr
20 25 30
Arg Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu
35 40 45
Ser Ser Ile Ser Asn Thr Asn Gly Asp Ile Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Val Ala Ser Asn Tyr Ala Tyr Phe Asp Leu Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 190
<211> 120
<212> PRT
<213> Homo sapiens
<400> 190
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Arg Phe Thr Asn Tyr
20 25 30
Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
35 40 45
Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe
50 55 60
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Thr Thr Ala Tyr
65 70 75 80
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
85 90 95
Ala Arg Leu Ser Asp Arg Trp Tyr Ser Pro Phe Asp Pro Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 191
<211> 115
<212> PRT
<213> Homo sapiens
<400> 191
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Gln Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn
20 25 30
Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Val Ile Tyr Ser Gly Gly Ser Ala Tyr Tyr Val Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Ile Ala Asn Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr
100 105 110
Val Ser Ser
115
<210> 192
<211> 127
<212> PRT
<213> Homo sapiens
<400> 192
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Trp Met His Trp Val Arg Gln Val Pro Gly Lys Gly Pro Val Trp Val
35 40 45
Ser His Ile Asn Ser Glu Gly Ser Ser Thr Asn Tyr Ala Asp Ser Val
50 55 60
Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asp Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Pro Thr Ala Val Ala Ala Ala Gly Asn Tyr Phe Tyr Tyr Tyr
100 105 110
Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 193
<211> 122
<212> PRT
<213> Homo sapiens
<400> 193
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Asn Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Cys Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu Arg Gly Tyr Asp Gly Gly Lys Thr Pro Pro Phe Leu Gly
100 105 110
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 194
<211> 122
<212> PRT
<213> Homo sapiens
<400> 194
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn
20 25 30
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Val Ile Tyr Ser Gly Tyr Ser Thr Tyr Tyr Val Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Val Gly Gly Ala His Ser Gly Tyr Asp Gly Ser Phe Asp Tyr Trp
100 105 110
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 195
<211> 127
<212> PRT
<213> Homo sapiens
<400> 195
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr
20 25 30
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Met Ser Tyr Asp Gly Ser Ser Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Cys
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gln Ala Gly Pro Tyr Cys Ser Gly Gly Ser Cys Tyr Ser Ala
100 105 110
Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 196
<211> 117
<212> PRT
<213> Homo sapiens
<400> 196
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Val Ser Ser Asn
20 25 30
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Asp Phe Gly Glu Phe Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu
100 105 110
Val Thr Val Ser Ser
115
<210> 197
<211> 124
<212> PRT
<213> Homo sapiens
<400> 197
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr
20 25 30
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Asp Pro Phe Pro Leu Ala Val Ala Gly Thr Gly Tyr Phe Asp
100 105 110
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 198
<211> 129
<212> PRT
<213> Homo sapiens
<400> 198
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Val Ser Thr Lys
20 25 30
Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Val Leu Tyr Ser Gly Gly Ser Asp Tyr Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ala Leu Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Val Glu Asp Thr Gly Val Tyr Tyr Cys Ala
85 90 95
Arg Asp Ser Ser Glu Val Arg Asp His Pro Gly His Pro Gly Arg Ser
100 105 110
Val Gly Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser
115 120 125
Ser
<210> 199
<211> 122
<212> PRT
<213> Homo sapiens
<400> 199
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr
20 25 30
Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Arg Ile Ile Pro Ile Val Gly Ile Ala Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Leu Leu Asp Pro Gln Leu Asp Asp Ala Phe Asp Ile Trp
100 105 110
Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120
<210> 200
<211> 121
<212> PRT
<213> Homo sapiens
<400> 200
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Val Lys Gly Val Glu Tyr Ser Ser Ser Ser Asn Phe Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 201
<211> 117
<212> PRT
<213> Homo sapiens
<400> 201
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn
20 25 30
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Leu Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Asp Thr Leu Gly Arg Gly Gly Asp Tyr Trp Gly Gln Gly Thr Leu
100 105 110
Val Thr Val Ser Ser
115
<210> 202
<211> 126
<212> PRT
<213> Homo sapiens
<400> 202
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Glu Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr
20 25 30
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Gly Ser Gly Ala Gly Thr Phe Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu Ser Asp Cys Gly Ser Thr Ser Cys Tyr Gln Val Gly Trp
100 105 110
Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 203
<211> 124
<212> PRT
<213> Homo sapiens
<400> 203
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly His Thr Phe Thr Ser Tyr
20 25 30
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Pro Glu Arg Gly Ile Val Gly Ala Thr Asp Tyr Phe Asp
100 105 110
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 204
<211> 121
<212> PRT
<213> Homo sapiens
<400> 204
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Pro Ile Gly Gln Pro Leu Leu Trp Trp Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 205
<211> 119
<212> PRT
<213> Homo sapiens
<400> 205
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr
20 25 30
Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
35 40 45
Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe
50 55 60
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65 70 75 80
Leu Lys Trp Ser Ser Leu Lys Ala Ser Asp Ser Ala Met Tyr Tyr Cys
85 90 95
Ala Arg Gly Pro Asn Leu Gln Asn Trp Phe Asp Pro Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 206
<211> 117
<212> PRT
<213> Homo sapiens
<400> 206
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn
20 25 30
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Phe Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Asp Leu Met Ala Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr
100 105 110
Val Thr Val Ser Ser
115
<210> 207
<211> 117
<212> PRT
<213> Homo sapiens
<400> 207
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Phe Thr Val Ser Ser Asn
20 25 30
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Asp Tyr Gly Asp Phe Tyr Phe Asp Phe Trp Gly Gln Gly Thr Leu
100 105 110
Val Thr Val Ser Ser
115
<210> 208
<211> 120
<212> PRT
<213> Homo sapiens
<400> 208
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Val Thr Gly Tyr
20 25 30
Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Ile Ser Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Trp Val Thr Met Thr Arg Asp Met Ser Ile Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu Arg Tyr Phe Asp Leu Gly Gly Met Asp Val Trp Gly Gln
100 105 110
Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 209
<211> 120
<212> PRT
<213> Homo sapiens
<400> 209
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Ala Ile Trp Tyr Asp Gly Ser Asn Lys His Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Val Gly Arg Val Thr Thr Trp Phe Asp Pro Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 210
<211> 122
<212> PRT
<213> Homo sapiens
<400> 210
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Thr Asp Ser Gly Asp Gly Thr Phe Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ser Glu Glu Asp Tyr Ser Asn Tyr Val Gly Trp Phe Asp Pro Trp
100 105 110
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 211
<211> 122
<212> PRT
<213> Homo sapiens
<400> 211
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Asp Met His Trp Val Arg Gln Ala Thr Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Gly Thr Ala Gly Asp Thr Tyr Tyr Pro Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Ser Leu Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Ala Gly Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Asp Arg Gly Ser Ser Gly Trp Tyr Gly Trp Tyr Phe Asp Leu Trp
100 105 110
Gly Arg Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 212
<211> 130
<212> PRT
<213> Homo sapiens
<400> 212
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu
50 55 60
Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu Gly Tyr Cys Ser Gly Gly Ser Cys Tyr Ser Gly Tyr Tyr
100 105 110
Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val
115 120 125
Ser Ser
130
<210> 213
<211> 119
<212> PRT
<213> Homo sapiens
<400> 213
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn
20 25 30
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Met Asn Thr Leu Phe Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Val Leu Pro Met Tyr Gly Asp Tyr Leu Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 214
<211> 117
<212> PRT
<213> Homo sapiens
<400> 214
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Val Ser Ser Asn
20 25 30
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Asp Leu Asp Val Tyr Gly Leu Asp Val Trp Gly Gln Gly Thr Thr
100 105 110
Val Thr Val Ser Ser
115
<210> 215
<211> 120
<212> PRT
<213> Homo sapiens
<400> 215
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Tyr Ser Gly Tyr
20 25 30
Phe Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Ile Ser Pro Asp Ser Gly Gly Ala Asn Tyr Ala Gln Thr Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Thr Thr Ala His
65 70 75 80
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Pro Arg Tyr Ser Gly Thr His Phe Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 216
<211> 120
<212> PRT
<213> Homo sapiens
<400> 216
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Ser Gly Tyr
20 25 30
Tyr Thr His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Ile Ser Pro Asp Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Thr Thr Ala Tyr
65 70 75 80
Val Glu Leu Ser Gly Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Pro Arg Tyr Ser Gly Thr Tyr Phe Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 217
<211> 120
<212> PRT
<213> Homo sapiens
<400> 217
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Tyr Ser Gly Tyr
20 25 30
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Ile Ser Pro Asp Ser Gly Gly Thr Asn Tyr Ala Gln Arg Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Pro Arg Tyr Ser Gly Thr Tyr Phe Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 218
<211> 123
<212> PRT
<213> Homo sapiens
<400> 218
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn
20 25 30
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Asp Pro Tyr Gly Tyr Ser Ser Ile Trp Asp Gly Gln Gly Gly His
100 105 110
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 219
<211> 133
<212> PRT
<213> Homo sapiens
<400> 219
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Tyr Tyr
20 25 30
Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
35 40 45
Ser Ser Ile Ser Thr Ser Ser Ser Phe Val Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys
85 90 95
Ala Arg Gly Gly Tyr Cys Ser Asp Gly Ser Cys Tyr Val Gln Asp Arg
100 105 110
Leu Ile Tyr Tyr Tyr Ser Gly Leu Asp Val Trp Gly Gln Gly Thr Thr
115 120 125
Val Thr Val Ser Ser
130
<210> 220
<211> 129
<212> PRT
<213> Homo sapiens
<400> 220
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr
20 25 30
Glu Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys
85 90 95
Ala Arg Asp Arg Arg Arg Arg Tyr Cys Thr Asn Gly Val Cys Tyr Arg
100 105 110
Pro Glu Glu Ile Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
115 120 125
Ser
<210> 221
<211> 124
<212> PRT
<213> Homo sapiens
<400> 221
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Leu Ile Trp Tyr Asp Gly Ser Asn Lys Asn Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Asp
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Pro Phe Pro Gly Ala Val Ala Gly Thr Gly Tyr Leu Gln
100 105 110
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 222
<211> 123
<212> PRT
<213> Homo sapiens
<400> 222
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asn Tyr
20 25 30
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Ser Ser Gly Ser Tyr Tyr Tyr Tyr Tyr Tyr Gly Met Asp Val
100 105 110
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 223
<211> 120
<212> PRT
<213> Homo sapiens
<400> 223
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Leu His Cys Gly Gly Asp Cys Tyr Leu Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 224
<211> 127
<212> PRT
<213> Homo sapiens
<400> 224
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Ser Gly Ser Gly Ser Tyr Pro Asn Tyr Tyr Tyr Tyr Tyr
100 105 110
Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 225
<211> 117
<212> PRT
<213> Homo sapiens
<400> 225
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn
20 25 30
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Val Phe Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Asp Tyr Gly Asp Leu Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu
100 105 110
Val Thr Val Ser Ser
115
<210> 226
<211> 134
<212> PRT
<213> Homo sapiens
<400> 226
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Ser Ser Leu Arg Gly Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Asp Gln Ala Tyr Tyr Asp Ile Leu Thr Gly Tyr Leu Asn Pro
100 105 110
Pro Lys Asn Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr
115 120 125
Thr Val Thr Val Ser Ser
130
<210> 227
<211> 120
<212> PRT
<213> Homo sapiens
<400> 227
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Thr Glu Leu
20 25 30
Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met
35 40 45
Gly Gly Phe Asp Pro Glu Asp Gly Glu Thr Ile Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr
65 70 75 80
Met Asp Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Thr Ala Phe Ser Ile Phe Gly Val Val Pro Pro Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Leu Val Thr Val Ser
115 120
<210> 228
<211> 123
<212> PRT
<213> Homo sapiens
<400> 228
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser
20 25 30
Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu
35 40 45
Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser
50 55 60
Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe
65 70 75 80
Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
85 90 95
Cys Ala Arg Gln Gly Asp Cys Ser Thr Thr Ser Cys Ala Tyr Asp Tyr
100 105 110
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 229
<211> 121
<212> PRT
<213> Homo sapiens
<400> 229
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Thr Phe Ser Ile Tyr
20 25 30
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Asp Arg Thr Gly Asn Tyr Tyr Tyr Gly Met Asp Val Trp Gly
100 105 110
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 230
<211> 125
<212> PRT
<213> Homo sapiens
<400> 230
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Gly Ser Gly Asp Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Asp Arg Tyr Tyr Glu Phe Trp Ser Gly Tyr Ser Asn Trp Phe
100 105 110
Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Ile Ser Ser
115 120 125
<210> 231
<211> 124
<212> PRT
<213> Homo sapiens
<400> 231
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr
20 25 30
Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
35 40 45
Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe
50 55 60
Gln Gly Gln Val Thr Val Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65 70 75 80
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
85 90 95
Ala Arg Val Asn Tyr Tyr Asp Ser Ser Gly Tyr Pro Ser Phe His Phe
100 105 110
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
115 120
<210> 232
<211> 124
<212> PRT
<213> Homo sapiens
<400> 232
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Gly Tyr
20 25 30
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Val Tyr
65 70 75 80
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu Met Pro Ala Ala Met Gly Tyr Tyr Tyr Tyr Gly Met Asp
100 105 110
Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 233
<211> 120
<212> PRT
<213> Homo sapiens
<400> 233
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr
20 25 30
Ala Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Ser Gly Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys
85 90 95
Ala Lys Ala Asn Lys Tyr Ser Ser Ser Glu Phe Asp Phe Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Ile Ser Ser
115 120
<210> 234
<211> 117
<212> PRT
<213> Homo sapiens
<400> 234
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn
20 25 30
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Ser Thr Leu Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Asp Phe Gly Asp Phe Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu
100 105 110
Val Thr Val Ser Ser
115
<210> 235
<211> 126
<212> PRT
<213> Homo sapiens
<400> 235
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr
20 25 30
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Ile Ser Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Trp Val Thr Met Thr Arg Asp Thr Ser Val Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Arg Leu Arg Phe Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Thr Glu Ser Trp Val Tyr Gly Ser Gly Ser Tyr Ser Ser Gly Ala
100 105 110
Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120 125
<210> 236
<211> 120
<212> PRT
<213> Homo sapiens
<400> 236
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Tyr Ser Gly Tyr
20 25 30
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Ile Ser Pro Asp Ser Gly Gly Thr Asn Tyr Ala Gln Arg Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Met Tyr Tyr Cys
85 90 95
Ala Arg Gly Pro Arg Tyr Ser Gly Thr Tyr Phe Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 237
<211> 120
<212> PRT
<213> Homo sapiens
<400> 237
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Ser Gly Tyr
20 25 30
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Ile Ser Pro Asp Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Thr Thr Gly Tyr
65 70 75 80
Met Glu Leu Ser Gly Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Pro Arg Tyr Ser Gly Thr Tyr Phe Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 238
<211> 120
<212> PRT
<213> Homo sapiens
<400> 238
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Thr Cys Lys Thr Ser Gly Tyr Ile Phe Ser Gly Tyr
20 25 30
Tyr Met His Trp Val Arg Gln Val Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Ile Ser Pro Asp Ser Gly Ala Thr Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Thr Thr Ser Tyr
65 70 75 80
Val Glu Leu Thr Trp Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Pro Arg Tyr Ser Gly Thr Tyr Phe Asp Phe Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 239
<211> 120
<212> PRT
<213> Homo sapiens
<400> 239
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Ser Gly Tyr
20 25 30
Tyr Thr His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Ile Ser Pro Asp Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Thr Thr Ala Tyr
65 70 75 80
Val Glu Leu Ser Gly Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Pro Arg Tyr Ser Gly Thr Tyr Phe Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 240
<211> 120
<212> PRT
<213> Homo sapiens
<400> 240
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Ser Gly Tyr
20 25 30
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Ile Ser Pro Asp Ser Gly Gly Thr Asn Tyr Ala Gln Asn Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Gly Tyr
65 70 75 80
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Met Tyr Tyr Cys
85 90 95
Ala Arg Gly Pro Arg Tyr Ser Gly Thr Tyr Phe Asp Tyr Trp Gly Gln
100 105 110
Gly Val Leu Val Thr Val Ser Ser
115 120
<210> 241
<211> 122
<212> PRT
<213> Homo sapiens
<400> 241
Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ala Thr Tyr
20 25 30
Ala Leu Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Val Asn Thr Asn Thr Gly Ser Pro Thr Tyr Ala Gln Gly Phe
50 55 60
Thr Gly Arg Phe Val Phe Ser Phe Asp Thr Ser Val Ser Thr Ala Tyr
65 70 75 80
Leu Gln Ile Arg Thr Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Val Tyr Tyr Tyr Asp Ser Gly Ser Pro Gly Trp Phe Asp Pro Trp
100 105 110
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 242
<211> 125
<212> PRT
<213> Homo sapiens
<400> 242
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ile Tyr
20 25 30
Ala Ile Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile Ile Pro Ile Ile Gly Thr Ala Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Phe Arg Tyr Cys Ser Ser Thr Arg Cys Tyr Phe Trp Phe
100 105 110
Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 243
<211> 119
<212> PRT
<213> Homo sapiens
<400> 243
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Met Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Ile Ile Ser Pro Ser Gly Gly Gly Thr Ser Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Leu Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Trp Tyr Asp Ser Thr Gly Ser Ile Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 244
<211> 121
<212> PRT
<213> Homo sapiens
<400> 244
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Ala Phe Ala Gly Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Lys Asp Gln Gly Tyr Ser Tyr Gly Asn Tyr Phe Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 245
<211> 118
<212> PRT
<213> Homo sapiens
<400> 245
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Ser
20 25 30
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile Ile Pro Ile Leu Asp Ile Thr Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Phe
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Leu Arg Asn Gln Trp Asp Leu Leu Val Tyr Trp Gly Gln Gly Thr
100 105 110
Leu Val Thr Val Ser Ser
115
<210> 246
<211> 121
<212> PRT
<213> Mus musculus
<400> 246
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Met Pro Gly Ala
1 5 10 15
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Ala Glu Asp Thr Ser Asp Ser Tyr Thr Ser Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Glu Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Arg Gly Tyr Gly Ser Ser Tyr Thr Trp Phe Ala Tyr Trp Gly
100 105 110
Gln Gly Thr Leu Val Thr Val Ser Ala
115 120
<210> 247
<211> 122
<212> PRT
<213> Homo sapiens
<400> 247
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr
20 25 30
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Val Ser Gly Tyr Asp Ser Ser Gly Tyr Trp Gly Asp Tyr Trp
100 105 110
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 248
<211> 119
<212> PRT
<213> Homo sapiens
<400> 248
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu
50 55 60
Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Gly Glu Leu Leu Gly Trp Phe Asp Pro Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 249
<211> 126
<212> PRT
<213> Homo sapiens
<400> 249
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr
20 25 30
Ala Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Gly Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala
50 55 60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile
65 70 75 80
Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
85 90 95
Tyr Cys Thr Arg Val Arg Arg Leu Trp Phe Gly Ser Tyr Tyr Tyr Gly
100 105 110
Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 250
<211> 126
<212> PRT
<213> Homo sapiens
<400> 250
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr
20 25 30
Ala Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Gly Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala
50 55 60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile
65 70 75 80
Val Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
85 90 95
Tyr Cys Thr Arg Val Arg Arg Leu Trp Phe Gly Ser Tyr Tyr Tyr Gly
100 105 110
Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 251
<211> 120
<212> PRT
<213> Homo sapiens
<400> 251
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Asn Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Asn Tyr
20 25 30
Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val
35 40 45
Gly Trp Ile His Ser Leu Ser Gly Gly Thr Ser Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Leu Thr Arg Asp Ala Ser Ile Arg Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Arg Leu Gly Ser Asp Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Arg Ala Ser Val Ser Thr Ile Thr Asp Phe Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Leu Val Ala Val Ser Ser
115 120
<210> 252
<211> 120
<212> PRT
<213> Homo sapiens
<400> 252
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Asn Tyr
20 25 30
Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val
35 40 45
Gly Trp Ile His Ser Leu Ser Gly Gly Thr Ser Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Leu Thr Arg Asp Ala Pro Ile Arg Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Gly Leu Gly Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ala Ser Val Ala Thr Ile Thr Asp Phe Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Leu Val Ala Val Ser Ser
115 120
<210> 253
<211> 121
<212> PRT
<213> Homo sapiens
<400> 253
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Tyr Tyr
20 25 30
Ala Ile Leu Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Ile Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Pro Gln Ser Gly Gly Tyr Tyr Ala Pro Leu Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 254
<211> 123
<212> PRT
<213> Homo sapiens
<400> 254
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr
20 25 30
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Gly Ile Ile Ser Tyr Asp Ala Ser Asp Lys Thr Tyr Ala Glu Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val Ser Ala Thr Tyr Tyr Tyr Tyr Tyr Tyr Gly Met Asp Val
100 105 110
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 255
<211> 126
<212> PRT
<213> Homo sapiens
<400> 255
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Thr Ala Thr Tyr Val Leu Leu Trp Ser Gly Asp Phe Asn
100 105 110
Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 256
<211> 121
<212> PRT
<213> Homo sapiens
<400> 256
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Thr Leu Ile Ser Tyr Asp Gly Gly Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Ala Ala Val Tyr Phe Cys
85 90 95
Ala Arg Gly His Thr Gly Asn Tyr Tyr Tyr Gly Met Asp Val Trp Gly
100 105 110
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 257
<211> 127
<212> PRT
<213> Homo sapiens
<400> 257
Gln Val His Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr
20 25 30
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Gly Asp Glu Asn Asn Lys Phe Tyr Ala Asn Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Ser
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Arg Tyr Tyr Cys
85 90 95
Ala Lys Gly Gly Asp Ser Ser Gly Trp Ala Trp Asp Gly Asp Asn Pro
100 105 110
Pro Thr Asp Tyr Trp Gly Gln Gly Thr Leu Val Ile Val Ser Ser
115 120 125
<210> 258
<211> 122
<212> PRT
<213> Homo sapiens
<400> 258
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Met Gly Pro Phe Gly Glu Leu Leu Pro Tyr Tyr Phe Asp Tyr Trp
100 105 110
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 259
<211> 121
<212> PRT
<213> Homo sapiens
<400> 259
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Thr Glu Leu
20 25 30
Ser Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met
35 40 45
Gly Gly Phe Asp Pro Glu Asp Ala Glu Thr Ile Tyr Ala Gln Asn Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Ala Ala Pro Ala Val Met Thr Ala Gly Trp Phe Asp Pro Trp Gly
100 105 110
Gln Gly Thr Leu Val Ser Val Ser Ser
115 120
<210> 260
<211> 116
<212> PRT
<213> Homo sapiens
<400> 260
Gln Val Gln Leu Glu Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser His
20 25 30
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
35 40 45
Gly Tyr Ile Gln Asp Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys
50 55 60
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
65 70 75 80
Arg Leu Ser Ser Val Thr Thr Ala Asp Thr Ala Val Tyr Tyr Cys Val
85 90 95
Arg Gly Ala Met Ala Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 261
<211> 121
<212> PRT
<213> Homo sapiens
<400> 261
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Ile Glu Leu
20 25 30
Ser Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met
35 40 45
Gly Gly Phe Asp Pro Glu Asp Val Glu Thr Ile Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Arg Ala Val Tyr Tyr Cys
85 90 95
Ala Thr Gln Pro Ala Ala Ile Gly Gly Thr Pro Pro Tyr Tyr Trp Gly
100 105 110
Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 262
<211> 128
<212> PRT
<213> Homo sapiens
<400> 262
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Val Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu
50 55 60
Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Gln Gly Pro Thr Tyr Tyr Tyr Gly Ser Gly Ser Pro His
100 105 110
Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 263
<211> 127
<212> PRT
<213> Homo sapiens
<400> 263
Gln Val His Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr
20 25 30
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Gly Asp Glu Asn Asn Lys Phe Tyr Ala Asn Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Ser
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Arg Tyr Tyr Cys
85 90 95
Ala Lys Gly Gly Asp Ser Ser Gly Trp Ala Trp Asp Gly Asp Asn Pro
100 105 110
Pro Thr Asp Tyr Trp Gly Gln Gly Thr Leu Val Ile Val Ser Ser
115 120 125
<210> 264
<211> 128
<212> PRT
<213> Homo sapiens
<400> 264
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Thr Glu Leu
20 25 30
Ser Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met
35 40 45
Gly Gly Phe Asp Pro Glu Asp Gly Glu Thr Val Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Ser Asp Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Thr Ser Phe Pro Ile Arg Gly Asp Pro Ser Tyr Tyr Tyr Tyr Tyr
100 105 110
Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 265
<211> 119
<212> PRT
<213> Homo sapiens
<400> 265
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Thr Tyr
20 25 30
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Asn Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ile Tyr Gly Tyr Tyr Tyr Tyr Gly Leu Asp Val Trp Gly Gln Gly
100 105 110
Thr Thr Val Thr Val Ser Ser
115
<210> 266
<211> 127
<212> PRT
<213> Homo sapiens
<400> 266
Gln Val His Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Arg Asn Tyr
20 25 30
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Gly Asp Glu Asn Asn Lys Phe Tyr Ala Asn Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Ser
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Arg Tyr Tyr Cys
85 90 95
Ala Lys Gly Gly Asp Ser Ser Gly Trp Ala Trp Asp Gly Asp Asn Pro
100 105 110
Pro Thr Asp Tyr Trp Gly Gln Gly Thr Leu Val Ile Val Ser Ser
115 120 125
<210> 267
<211> 119
<212> PRT
<213> Homo sapiens
<400> 267
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly
1 5 10 15
Thr Leu Ser Leu Thr Cys Val Val Ser Gly Gly Ser Ile Ser Ser Ser
20 25 30
Asn Trp Gly Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
35 40 45
Gly Glu Ile Tyr Leu Ser Gly Thr Thr Asn Tyr Asn Pro Ser Leu Thr
50 55 60
Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser Leu
65 70 75 80
Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr Cys Ala
85 90 95
Arg Pro Thr Ala Gly Ala Gly Gly Ala Phe Asp Ile Trp Gly Gln Gly
100 105 110
Thr Val Val Thr Val Ser Ser
115
<210> 268
<211> 122
<212> PRT
<213> Homo sapiens
<400> 268
Gln Val Thr Leu Lys Glu Ser Gly Pro Val Leu Val Lys Pro Thr Glu
1 5 10 15
Thr Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Asn Ala
20 25 30
Arg Met Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu
35 40 45
Trp Leu Ala His Ile Phe Trp Asn Asp Glu Asn Ser Tyr Ser Thr Ser
50 55 60
Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val
65 70 75 80
Val Leu Asn Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr
85 90 95
Cys Ala Arg Thr Glu Trp Leu Leu Ser Asp Asn Trp Phe Asp Ser Trp
100 105 110
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 269
<211> 122
<212> PRT
<213> Homo sapiens
<400> 269
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Asp Thr Phe Ser Ser Tyr
20 25 30
Tyr Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Gln Trp Met
35 40 45
Gly Ile Ser Asn Pro Ser Gly Gly Ser Thr Thr Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Gly Asp Thr Ser Thr Ser Thr Val Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Gly Leu Val Pro Ala Ala Arg Asn Ala Phe Asp Ile Trp
100 105 110
Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120
<210> 270
<211> 119
<212> PRT
<213> Homo sapiens
<400> 270
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly
1 5 10 15
Thr Leu Ser Leu Thr Cys Val Val Ser Gly Gly Ser Ile Ser Ser Ser
20 25 30
Asn Trp Gly Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
35 40 45
Gly Glu Ile Tyr His Ser Gly Thr Thr Asn Tyr Asn Pro Ser Leu Arg
50 55 60
Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Leu Ser Leu
65 70 75 80
Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr Cys Ala
85 90 95
Arg Pro Thr Ala Gly Ala Gly Gly Ala Phe Asp Thr Trp Gly Gln Gly
100 105 110
Thr Met Val Thr Val Ser Ala
115
<210> 271
<211> 127
<212> PRT
<213> Homo sapiens
<400> 271
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr
20 25 30
Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Ile Ser Ala Tyr Asn Gly Asn Ser Asn Tyr Gly Lys Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Leu Pro Ile Lys Val Val Val Pro Ala Ala Asp Tyr Asn
100 105 110
Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 272
<211> 122
<212> PRT
<213> Homo sapiens
<400> 272
Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln
1 5 10 15
Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Asn Thr Asn
20 25 30
Gly Val Ala Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu
35 40 45
Trp Leu Ala Leu Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Ser Pro Ser
50 55 60
Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val
65 70 75 80
Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr
85 90 95
Cys Ala His Arg Arg Gly Ile Leu Thr Glu Asp Ala Phe Asp Ile Trp
100 105 110
Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120
<210> 273
<211> 117
<212> PRT
<213> Homo sapiens
<400> 273
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Glu
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Val Ser Ser Asn
20 25 30
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Ile Ile Ser Arg His Asn Ser Lys Asn Thr Leu Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Asp Leu Asn Glu His Gly Leu Asp Val Trp Gly Gln Gly Thr Thr
100 105 110
Val Ser Val Ser Ser
115
<210> 274
<211> 122
<212> PRT
<213> Homo sapiens
<400> 274
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Ile Ile Asn Pro Ser Ala Gly Ser Thr Ser Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Thr Leu Ile Pro Ala His Arg Gly Ala Phe Asp Ile Trp
100 105 110
Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120
<210> 275
<211> 123
<212> PRT
<213> Homo sapiens
<400> 275
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly
20 25 30
Thr Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu
35 40 45
Trp Ile Gly Arg Phe Tyr Thr Ser Gly Ser Thr Asn Tyr Asn Pro Ser
50 55 60
Leu Lys Ser Arg Val Thr Ile Ser Val Asp Ala Ser Lys Asn Gln Phe
65 70 75 80
Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
85 90 95
Cys Ala Arg Ala Arg Pro Asp Tyr Tyr Tyr Tyr Tyr Ala Met Asp Val
100 105 110
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 276
<211> 123
<212> PRT
<213> Homo sapiens
<400> 276
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Ala Tyr Thr Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Lys Ala His Ser Thr Gly His Gln Tyr Tyr Tyr Gly Met Asp Val
100 105 110
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 277
<211> 130
<212> PRT
<213> Homo sapiens
<400> 277
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Ile Asn Pro Asn Ser Arg Gly Thr Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Val Tyr
65 70 75 80
Met Glu Leu Ser Arg Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Val Val Val Leu Gly Tyr Gly Arg Pro Asn Asn Tyr Tyr Asp
100 105 110
Gly Arg Asn Val Trp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val
115 120 125
Ser Ser
130
<210> 278
<211> 117
<212> PRT
<213> Homo sapiens
<400> 278
Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Gly Thr Ser
20 25 30
Gly Met Cys Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu
35 40 45
Trp Leu Ala Arg Ile Asp Trp Asp Asp Asp Lys Tyr Tyr Ser Thr Ser
50 55 60
Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val
65 70 75 80
Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr
85 90 95
Cys Ala Arg Gly Val Val Thr Tyr Asp Tyr Trp Gly Gln Gly Thr Leu
100 105 110
Val Thr Val Ser Ser
115
<210> 279
<211> 124
<212> PRT
<213> Homo sapiens
<400> 279
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Asp Thr Phe Ser Ser Tyr
20 25 30
Thr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Arg Ile Ile Pro Ile Leu Gly Ile Pro Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Phe
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Arg Gly Tyr Ser Asn Tyr Gly Ala Ser Tyr Tyr Met Asp
100 105 110
Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 280
<211> 121
<212> PRT
<213> Homo sapiens
<400> 280
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Gly Ile Ser Trp Asn Ser Asp Ser Ile Gly Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys
85 90 95
Ala Lys Gly Arg Gly Ala Gly Tyr Thr Ser Tyr Met Asp Val Trp Gly
100 105 110
Lys Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 281
<211> 123
<212> PRT
<213> Homo sapiens
<400> 281
Gln Val Gln Leu Ala Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ala Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Asp Ile Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Met Asn Ser Asn Ser Gly Asn Ala Gly Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Met Arg Thr Gly Trp Pro Thr His Gly Arg Pro Asp Asp Phe
100 105 110
Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 282
<211> 122
<212> PRT
<213> Homo sapiens
<400> 282
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn
20 25 30
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Val Ile Tyr Pro Gly Gly Ser Ala Phe Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg His Asn Ser Asn Asn Thr Leu Cys Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Ser Tyr Asp Ile Leu Thr Gly Tyr Arg Asp Ala Phe Asp Ile Trp
100 105 110
Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120
<210> 283
<211> 122
<212> PRT
<213> Homo sapiens
<400> 283
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Phe Ser Ala Tyr
20 25 30
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
35 40 45
Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Arg
50 55 60
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
65 70 75 80
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Val Gly Tyr Ser Gln Gly Tyr Tyr Tyr Tyr Tyr Met Asp Val Trp
100 105 110
Gly Lys Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 284
<211> 123
<212> PRT
<213> Homo sapiens
<400> 284
Gln Met Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Thr
1 5 10 15
Ser Val Lys Val Ser Cys Lys Thr Ser Gly Phe Thr Phe Thr Ser Ser
20 25 30
Ala Ile Gln Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Ile
35 40 45
Gly Trp Ile Val Val Gly Ser Gly Asn Thr Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Glu Arg Val Thr Ile Thr Arg Asp Met Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ala Pro His Cys Asn Arg Thr Ser Cys Tyr Asp Ala Phe Asp Leu
100 105 110
Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120
<210> 285
<211> 125
<212> PRT
<213> Homo sapiens
<400> 285
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr
20 25 30
Ser Ile Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Arg Ile Ile Pro Val Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Val Gly Val Ser Gly Phe Lys Ser Gly Ser Asn Trp Tyr Phe
100 105 110
Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 286
<211> 117
<212> PRT
<213> Homo sapiens
<400> 286
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Val Arg Ser Asn
20 25 30
Tyr Met Thr Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Asp Leu Val Thr Tyr Gly Leu Asp Val Trp Gly Gln Gly Thr Thr
100 105 110
Val Thr Val Ser Ser
115
<210> 287
<211> 129
<212> PRT
<213> Homo sapiens
<400> 287
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Asp Asp Tyr
20 25 30
Asp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Gly Ile Ser Trp Asn Gly Gly Asn Thr Gly Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr His Cys
85 90 95
Ala Val Ile Met Ser Pro Ile Pro Arg Tyr Ser Gly Tyr Asp Trp Ala
100 105 110
Gly Gly Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser
115 120 125
Ser
<210> 288
<211> 127
<212> PRT
<213> Homo sapiens
<400> 288
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr
20 25 30
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Met Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Asn Leu Gly Pro Tyr Cys Ser Gly Gly Thr Cys Tyr Ser Leu
100 105 110
Val Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 289
<211> 129
<212> PRT
<213> Homo sapiens
<400> 289
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Asp Asp Tyr
20 25 30
Asp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Gly Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr His Cys
85 90 95
Ala Val Ile Met Ser Pro Ile Pro Arg Tyr Ser Gly Tyr Asp Trp Ala
100 105 110
Gly Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser
115 120 125
Ser
<210> 290
<211> 123
<212> PRT
<213> Homo sapiens
<400> 290
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Gly Ser Phe
20 25 30
Asp Ile Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Arg Met Asn Ser Asn Ser Gly Asn Thr Ala Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Asn Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys
85 90 95
Ala Arg Met Arg Ser Gly Trp Pro Thr His Gly Arg Pro Asp Asp Phe
100 105 110
Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 291
<211> 121
<212> PRT
<213> Homo sapiens
<400> 291
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Gly Ile Ser Trp Asn Ser Gly Thr Ile Gly Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Lys Asp Ile Ile Arg Gln Gly Glu Asp Gly Met Asp Val Trp Gly
100 105 110
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 292
<211> 118
<212> PRT
<213> Homo sapiens
<400> 292
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr
20 25 30
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Gly Ile Ile Ser Thr Ser Gly Gly Ala Thr Tyr Asn Ala Asp Ser
50 55 60
Val Arg Gly Arg Phe Thr Thr Ser Arg Asp Asn Ser Lys Asn Ile Leu
65 70 75 80
Tyr Leu Gln Met Asn Ser Leu Arg Gly Glu Asp Thr Ala Val Tyr Tyr
85 90 95
Cys Val Lys Gly Leu Phe Asp Trp Phe Pro Leu Trp Gly Gln Gly Thr
100 105 110
Met Val Thr Val Ser Ser
115
<210> 293
<211> 119
<212> PRT
<213> Homo sapiens
<400> 293
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg His
20 25 30
Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val
50 55 60
Lys Gly Arg Leu Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Leu Gly Phe Tyr Tyr Gly Gly Ala Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 294
<211> 122
<212> PRT
<213> Homo sapiens
<400> 294
Asn Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe His His Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Gly Ile Ser Gly Ser Ser Asp Tyr Arg Ala Tyr Ala Asp Ser Leu
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Tyr Ala Lys Asn Ser Leu Trp
65 70 75 80
Leu Gln Met Asn Ser Leu Thr Ser Glu Asp Thr Ala Phe Tyr Tyr Cys
85 90 95
Ala Lys Gly Val Asp Tyr Gly Gly Lys Leu Ala Tyr Phe Asp Ser Trp
100 105 110
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 295
<211> 124
<212> PRT
<213> Homo sapiens
<400> 295
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Tyr
20 25 30
Val Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Gln Leu Glu Trp
35 40 45
Val Ala Val Ile Ser Tyr Asp Gly Ser Ser Lys Tyr Tyr Ala Asp Ser
50 55 60
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu
65 70 75 80
Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr
85 90 95
Cys Ala Arg Asp Ile Asp Ser Gly Tyr Asp Pro Thr Pro Val Phe Asp
100 105 110
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 296
<211> 122
<212> PRT
<213> Homo sapiens
<400> 296
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Asp Leu His Trp Val Arg Gln Gly Thr Gly Lys Arg Leu Glu Trp Val
35 40 45
Ser Ala Ile Gly Thr Ala Gly Asp Thr Tyr Tyr Leu Gly Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Ser Leu Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Ala Gly Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Val Leu Tyr Asp Ser Ser Gly Phe Tyr Asn Trp Phe Asp Pro Trp
100 105 110
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 297
<211> 116
<212> PRT
<213> Homo sapiens
<400> 297
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Val Thr Val Ser Ser Asn
20 25 30
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Leu Ile Tyr Ser Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Asp Phe Leu Arg Trp His Asp Leu Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 298
<211> 124
<212> PRT
<213> Homo sapiens
<400> 298
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Asp Thr Phe Ser Ser Tyr
20 25 30
Thr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Arg Ile Ile Pro Ile Leu Gly Ile Pro Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Phe
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Arg Gly Tyr Ser Asn Tyr Gly Ala Ser Tyr Tyr Met Asp
100 105 110
Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 299
<211> 122
<212> PRT
<213> Homo sapiens
<400> 299
Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser
20 25 30
Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Asn Gly Leu Glu
35 40 45
Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser
50 55 60
Leu Lys Gly Arg Val Ser Ile Ser Val Asp Thr Ser Lys Asn Gln Phe
65 70 75 80
Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
85 90 95
Cys Ala Arg Ile Leu Val Ile Phe Thr Leu Asn Trp Phe Asp Pro Trp
100 105 110
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 300
<211> 131
<212> PRT
<213> Homo sapiens
<400> 300
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Val
20 25 30
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Gly Arg Ile Lys Ser Lys Ile Asp Gly Gly Thr Thr Asp Tyr Ala Ala
50 55 60
Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr
65 70 75 80
Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
85 90 95
Tyr Cys Thr Thr Ala Gly Ser Tyr Tyr Tyr Asp Thr Val Gly Pro Gly
100 105 110
Leu Pro Glu Gly Lys Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr
115 120 125
Val Ser Ser
130
<210> 301
<211> 116
<212> PRT
<213> Homo sapiens
<400> 301
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Val Thr Val Ser Ser Asn
20 25 30
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Leu Ile Tyr Ser Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Asp Phe Leu Arg Trp His Asp Leu Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 302
<211> 122
<212> PRT
<213> Homo sapiens
<400> 302
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Gly
20 25 30
Ser Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu
35 40 45
Cys Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Ser Asn Tyr Asn Pro Ser
50 55 60
Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe
65 70 75 80
Ser Leu Lys Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
85 90 95
Cys Ala Gly Ser Pro Val Pro Pro Thr Ile Val Gly Ala Ser Tyr Trp
100 105 110
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 303
<211> 121
<212> PRT
<213> Homo sapiens
<400> 303
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr
20 25 30
Trp Ile Asp Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
35 40 45
Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe
50 55 60
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Thr Ser Thr Ala Tyr
65 70 75 80
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
85 90 95
Ala Arg Arg Gly Glu Ala Ala Gly Ile Trp Tyr Phe Asp Leu Trp Gly
100 105 110
Arg Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 304
<211> 124
<212> PRT
<213> Homo sapiens
<400> 304
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn
20 25 30
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Val Ile Tyr Ser Ala Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Ser Ile Ser Arg Asp Lys Ser Lys Asn Thr Leu Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Lys Glu Gly Gly Ser Gly Ser Leu Arg Tyr Tyr Tyr Tyr Gly Met Asp
100 105 110
Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 305
<211> 124
<212> PRT
<213> Homo sapiens
<400> 305
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Ser Ser Ser
20 25 30
Glu Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser His Ile Ser Ser Ser Gly Ser Ile Ile Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Arg Ser Tyr Arg Ser Ser Trp Tyr Tyr Tyr Tyr Gly Met Asp
100 105 110
Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 306
<211> 121
<212> PRT
<213> Homo sapiens
<400> 306
Gln Val Gln Leu Ala Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ser Thr Ser Gly Ser Tyr Tyr Tyr Gly Met Asp Val Trp Gly
100 105 110
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 307
<211> 124
<212> PRT
<213> Homo sapiens
<400> 307
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Ile Gly Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Trp Ala Pro Thr Tyr Tyr Asp Met Pro Ser Ala Phe Asp
100 105 110
Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120
<210> 308
<211> 119
<212> PRT
<213> Homo sapiens
<400> 308
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Arg Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr
20 25 30
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile Ile Pro Val Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Phe
65 70 75 80
Met Glu Leu Asn Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ile Gly Ser Tyr Pro Glu Tyr Phe Gln His Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 309
<211> 121
<212> PRT
<213> Homo sapiens
<400> 309
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly
20 25 30
Gly Tyr Phe Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu
35 40 45
Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser
50 55 60
Leu Arg Ser Arg Ile Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe
65 70 75 80
Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
85 90 95
Cys Ala Arg Gly Gly Ser Gly Ser Tyr Ser Leu Phe Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 310
<211> 121
<212> PRT
<213> Homo sapiens
<400> 310
Gln Val Gln Leu Ala Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ser Thr Ser Gly Ser Tyr Tyr Tyr Gly Met Asp Val Trp Gly
100 105 110
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 311
<211> 121
<212> PRT
<213> Homo sapiens
<400> 311
Gln Val Gln Leu Ala Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ser Thr Ser Gly Ser Tyr Tyr Tyr Gly Met Asp Val Trp Gly
100 105 110
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 312
<211> 117
<212> PRT
<213> Homo sapiens
<400> 312
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Val Arg Ser Asn
20 25 30
Tyr Met Thr Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Asp Leu Val Thr Tyr Gly Leu Asp Val Trp Gly Gln Gly Thr Thr
100 105 110
Val Thr Val Ser Ser
115
<210> 313
<211> 122
<212> PRT
<213> Homo sapiens
<400> 313
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr
20 25 30
Ala Ile Ile Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile Ile Pro Ile Phe Gly Thr Thr Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65 70 75 80
Val Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ile Gly His Phe Asp Ser Ser Gly Tyr Tyr Leu Asp Tyr Trp
100 105 110
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 314
<211> 119
<212> PRT
<213> Homo sapiens
<400> 314
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Phe Tyr
20 25 30
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Asn Ile Lys Gln Asp Gly Gly Glu Lys Tyr Tyr Val Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Leu Ser Gly Ser Ser Trp Asp Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 315
<211> 129
<212> PRT
<213> Homo sapiens
<400> 315
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr His Cys
85 90 95
Ala Arg Arg Arg Ser Ser Ser Arg Tyr Ser Ser Gly Trp Tyr Met Tyr
100 105 110
Tyr Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser
115 120 125
Ser
<210> 316
<211> 119
<212> PRT
<213> Homo sapiens
<400> 316
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Phe Tyr
20 25 30
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Asn Ile Lys Gln Asp Gly Gly Glu Lys Tyr Tyr Val Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Leu Ser Gly Ser Ser Trp Asp Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 317
<211> 120
<212> PRT
<213> Homo sapiens
<400> 317
Gln Ile Thr Phe Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Glu
1 5 10 15
Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Val Ser Thr Ser
20 25 30
Gly Glu Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu
35 40 45
Trp Leu Ala Val Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Ser Pro Ser
50 55 60
Leu Lys Ser Arg Leu Thr Ile Thr Arg Asp Thr Ser Lys Asn Gln Val
65 70 75 80
Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr
85 90 95
Cys Ala His Arg Leu Trp Phe Arg Asp Ala Phe Asp Ile Trp Gly Gln
100 105 110
Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 318
<211> 119
<212> PRT
<213> Homo sapiens
<400> 318
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr
20 25 30
Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val
50 55 60
Lys Tyr Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Val Gly Ser Ser Ser Trp Tyr Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 319
<211> 121
<212> PRT
<213> Homo sapiens
<400> 319
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Gly Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ala Asp Thr Met Val Arg Gly Thr Tyr Phe Glu Tyr Trp Gly
100 105 110
Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 320
<211> 119
<212> PRT
<213> Homo sapiens
<400> 320
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Tyr Tyr
20 25 30
Pro Met His Trp Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu
35 40 45
Trp Val Ala Val Thr Ser Tyr Asp Gly Thr Asn Lys Tyr Tyr Ala Asp
50 55 60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr
65 70 75 80
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
85 90 95
Tyr Cys Ala Arg Gly Gly Ala Thr Asn Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 321
<211> 126
<212> PRT
<213> Homo sapiens
<400> 321
Glu Ala Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Ser
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Gly Ile Ser Trp Asn Ser Gly Asn Val Gly Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Thr Lys Ala Ser Arg Tyr Cys Ser Ser Thr Ile Cys Tyr Trp Asn Trp
100 105 110
Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 322
<211> 126
<212> PRT
<213> Homo sapiens
<400> 322
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Glu Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Tyr Ile Ser Ser Ser Gly Ser Ala Ile Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu Ala Arg Ser Arg Tyr Phe Asp Trp Leu Pro Ser Tyr Tyr
100 105 110
Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 323
<211> 129
<212> PRT
<213> Homo sapiens
<400> 323
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr His Cys
85 90 95
Ala Arg Arg Arg Ser Ser Ser Arg Tyr Ser Ser Gly Trp Tyr Met Tyr
100 105 110
Tyr Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser
115 120 125
Ser
<210> 324
<211> 127
<212> PRT
<213> Homo sapiens
<400> 324
Gln Val His Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr
20 25 30
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Asn Asp Glu Phe Asn Lys Phe Tyr Ala Asn Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Leu Asn Ser Leu Arg Thr Glu Asp Thr Ala Arg Tyr Tyr Cys
85 90 95
Ala Lys Gly Gly Asp Gly Ser Gly Trp Ala Trp Asp Gly Asp Asn Pro
100 105 110
Pro Thr Asp Tyr Trp Gly Gln Gly Thr Leu Val Ile Val Ser Ser
115 120 125
<210> 325
<211> 123
<212> PRT
<213> Homo sapiens
<400> 325
Gln Met Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Thr
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Met Ser Ser
20 25 30
Ala Val Gln Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Ile
35 40 45
Gly Trp Ile Val Ile Gly Ser Gly Asn Thr Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Glu Arg Val Thr Ile Thr Arg Asp Met Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ala Pro Tyr Cys Ser Ser Ile Ser Cys Asn Asp Gly Phe Asp Ile
100 105 110
Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120
<210> 326
<211> 124
<212> PRT
<213> Homo sapiens
<400> 326
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr
20 25 30
Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
35 40 45
Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe
50 55 60
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65 70 75 80
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
85 90 95
Ala Arg Pro Asp Tyr Ser Ser Gly Trp Phe Ser Tyr Trp Tyr Phe Asp
100 105 110
Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 327
<211> 121
<212> PRT
<213> Homo sapiens
<400> 327
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Thr Glu Leu
20 25 30
Ser Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met
35 40 45
Gly Gly Phe Asp Pro Glu Asp Ala Glu Thr Ile Tyr Ala Gln Gln Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Lys Ser Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Thr Gly Phe Ala Val Phe Gly Arg Ala Ala Val Pro Tyr Trp Gly
100 105 110
Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 328
<211> 121
<212> PRT
<213> Homo sapiens
<400> 328
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Ala Trp Val
35 40 45
Ala Leu Ile Ser Tyr Asp Gly Tyr Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Arg Gly Arg Phe Thr Ile Ser Arg Ile Asn Ser Lys Asn Thr Leu Ser
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Ser Ala Gly Asn Tyr Tyr Tyr Gly Met Asp Val Trp Gly
100 105 110
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 329
<211> 121
<212> PRT
<213> Homo sapiens
<400> 329
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser His
20 25 30
Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
35 40 45
Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe
50 55 60
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65 70 75 80
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
85 90 95
Ala Ser Ala Leu Arg Glu Arg Gly Val Gln Leu Trp Ser Val Trp Gly
100 105 110
Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 330
<211> 122
<212> PRT
<213> Homo sapiens
<400> 330
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Gln Glu Trp Phe Arg Glu Leu Phe Leu Phe Asp Tyr Trp
100 105 110
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 331
<211> 128
<212> PRT
<213> Homo sapiens
<400> 331
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Ser Asn Ser Asn Ser Phe Ile Tyr Tyr Ala Asp Ser Met
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Val Asn Gly Asn Ser Asn Trp Asn Phe Gly Ser Tyr Tyr Tyr
100 105 110
Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 332
<211> 122
<212> PRT
<213> Homo sapiens
<400> 332
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr
20 25 30
Ala Ile Ile Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile Ile Pro Ile Phe Gly Thr Thr Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65 70 75 80
Val Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ile Gly His Phe Asp Ser Ser Gly Tyr Tyr Leu Asp Tyr Trp
100 105 110
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 333
<211> 124
<212> PRT
<213> Homo sapiens
<400> 333
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr
20 25 30
Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Trp Leu Gln Leu Arg Ser Asp Tyr Tyr Tyr Phe Gly Met Asp
100 105 110
Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 334
<211> 122
<212> PRT
<213> Homo sapiens
<400> 334
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr
20 25 30
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile Ile Pro Ile Phe Gly Ala Ala Asn Tyr Ala Gln Asn Phe
50 55 60
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Gly Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Arg Phe Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Thr Ser His Tyr Asp Ser Ser Gly Ser Tyr Phe Glu Tyr Trp
100 105 110
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 335
<211> 121
<212> PRT
<213> Homo sapiens
<400> 335
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Ala Leu Phe Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Pro Tyr Thr Gly Ser Tyr Lys Ser Tyr Met Asp Val Trp Gly
100 105 110
Lys Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 336
<211> 123
<212> PRT
<213> Homo sapiens
<400> 336
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr
20 25 30
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
35 40 45
Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys
50 55 60
Ser Arg Val Thr Ile Ser Val Asp Met Ser Lys Asn Gln Phe Ser Leu
65 70 75 80
Lys Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Ala Pro Arg Glu Arg Leu Gln Trp Gly Glu Tyr Tyr Phe Asp Tyr
100 105 110
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 337
<211> 118
<212> PRT
<213> Homo sapiens
<400> 337
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr
20 25 30
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys
85 90 95
Ala Lys Asp Gly Ser Ile Ala Ala Ala Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Leu Val Thr Val Ser Ser
115
<210> 338
<211> 121
<212> PRT
<213> Homo sapiens
<400> 338
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asn Ser
20 25 30
Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
35 40 45
Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe
50 55 60
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65 70 75 80
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Ile Tyr Tyr Cys
85 90 95
Ala Thr His Arg Cys Ser Gly Gly Phe Cys Tyr Leu Ala Tyr Trp Gly
100 105 110
Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 339
<211> 128
<212> PRT
<213> Homo sapiens
<400> 339
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Trp Tyr Asp Gly Ser Lys Lys Asp Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Gln Ser Gln Gly Ala Tyr Ile Leu Thr Gly Tyr Arg Gly
100 105 110
Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 340
<211> 123
<212> PRT
<213> Homo sapiens
<400> 340
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly His
20 25 30
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
35 40 45
Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys
50 55 60
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
65 70 75 80
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Pro Pro Gln Ala Ala Arg Ile His Tyr Tyr Tyr Tyr Met Asp Val
100 105 110
Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 341
<211> 121
<212> PRT
<213> Homo sapiens
<400> 341
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Gly Ile Ser Trp Asn Ser Asp Ser Ile Gly Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys
85 90 95
Ala Lys Gly Arg Gly Ala Gly Tyr Thr Ser Tyr Met Asp Val Trp Gly
100 105 110
Lys Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 342
<211> 112
<212> PRT
<213> Homo sapiens
<400> 342
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Val Ser Ser Asn
20 25 30
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Glu Ser Thr Gln Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
100 105 110
<210> 343
<211> 119
<212> PRT
<213> Homo sapiens
<400> 343
Gln Ile Thr Leu Lys Glu Ser Gly Pro Pro Leu Val Glu Pro Lys Gln
1 5 10 15
Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser
20 25 30
Gly Glu Ala Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu
35 40 45
Trp Leu Ala Leu Ile Tyr Trp Asp Asp Asp Lys His Tyr Ser Pro Ser
50 55 60
Leu Arg Asn Arg Leu Thr Ile Thr Arg Asp Thr Ser Lys Asn Gln Val
65 70 75 80
Val Leu Thr Leu Thr Asn Val Asp Pro Ala Asp Thr Gly Thr Tyr Tyr
85 90 95
Cys Ala His Arg Ala Val Ile Leu Asn Phe Asp His Trp Gly Gln Gly
100 105 110
Phe Leu Val Thr Val Ser Ser
115
<210> 344
<211> 121
<212> PRT
<213> Homo sapiens
<400> 344
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Ile Asn Lys Tyr Tyr Ala Asp Ala Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Pro Arg Ser Gly Ser Tyr Tyr Ala Tyr Phe Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 345
<211> 125
<212> PRT
<213> Homo sapiens
<400> 345
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Lys Val Gly Tyr Thr Ile Ser Arg Gln Trp Leu Val Gly Glu Phe
100 105 110
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 346
<211> 121
<212> PRT
<213> Homo sapiens
<400> 346
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr
20 25 30
Trp Ile Asp Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
35 40 45
Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe
50 55 60
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Thr Ser Thr Ala Tyr
65 70 75 80
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
85 90 95
Ala Arg Arg Gly Glu Ala Ala Gly Ile Trp Tyr Phe Asp Leu Trp Gly
100 105 110
Arg Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 347
<211> 123
<212> PRT
<213> Homo sapiens
<400> 347
Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
1 5 10 15
Thr Leu Pro Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser
20 25 30
Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Gln
35 40 45
Trp Ile Gly Asn Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Ser Ser
50 55 60
Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe
65 70 75 80
Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
85 90 95
Cys Ala Arg Gln Ser Arg Gly Tyr Ser Tyr Ala Trp Ser Phe Asp Tyr
100 105 110
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 348
<211> 124
<212> PRT
<213> Homo sapiens
<400> 348
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr
20 25 30
Gly Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val
35 40 45
Ala Gly Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Val Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Gly Ser Ser Gly Glu Gly Gly Leu Tyr Tyr Tyr Tyr Gly Met Asp
100 105 110
Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 349
<211> 122
<212> PRT
<213> Homo sapiens
<400> 349
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Ser Tyr
20 25 30
Gly Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys His Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Val Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Ser Gly Gly Asn Tyr Gly Asp Ser Tyr Phe Asp Tyr Trp
100 105 110
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 350
<211> 121
<212> PRT
<213> Homo sapiens
<400> 350
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Ala Trp Val
35 40 45
Ala Leu Ile Ser Tyr Asp Gly Tyr Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Arg Gly Arg Phe Thr Ile Ser Arg Ile Asn Ser Lys Asn Thr Leu Ser
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Ser Ala Gly Asn Tyr Tyr Tyr Gly Met Asp Val Trp Gly
100 105 110
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 351
<211> 126
<212> PRT
<213> Homo sapiens
<400> 351
Gln Val Thr Leu Lys Glu Ser Gly Pro Val Leu Val Lys Pro Thr Glu
1 5 10 15
Thr Leu Thr Leu Thr Cys Ala Val Ser Gly Phe Ser Leu Ser Asn Ala
20 25 30
Lys Met Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu
35 40 45
Trp Leu Ala His Ile Phe Ser Asn Asp Glu Lys Ala Tyr Ser Thr Ser
50 55 60
Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val
65 70 75 80
Val Leu Thr Val Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr
85 90 95
Cys Ala Arg Ile Val Leu Gly Ala Ser Gly Thr Tyr Pro Ser Pro Gly
100 105 110
Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 352
<211> 119
<212> PRT
<213> Homo sapiens
<400> 352
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Trp Met His Trp Val Arg Gln Val Pro Gly Lys Gly Leu Val Trp Val
35 40 45
Ser Arg Ile Asn Ser Asp Gly Ser Ser Thr Ser Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met Asn Ser Leu Arg Ala Gln Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Gly Ser Pro Trp Leu Arg Gly Asp Ile Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 353
<211> 127
<212> PRT
<213> Homo sapiens
<400> 353
Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Thr Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Ile Asn Thr Asp Thr Gly Asn Pro Thr Tyr Ala Gln Gly Phe
50 55 60
Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr
65 70 75 80
Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Pro Ser Tyr Cys Ser Ser Thr Arg Cys Tyr Thr Val Gly
100 105 110
Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 354
<211> 121
<212> PRT
<213> Homo sapiens
<400> 354
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Asn Ser Gly
20 25 30
Asn Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu
35 40 45
Trp Ile Gly Arg Met Phe Thr Ser Gly Ser Thr Asn Tyr Asn Pro Ser
50 55 60
Leu Thr Ser Arg Val Thr Met Ser Ile Asp Thr Ser Lys Asn Gln Phe
65 70 75 80
Ser Leu Asn Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Met Tyr Tyr
85 90 95
Cys Ala Arg Gly His Val Ala Ala Trp Glu Ser Cys Tyr Tyr Trp Gly
100 105 110
Gln Gly Ile Leu Val Thr Val Ser Ser
115 120
<210> 355
<211> 130
<212> PRT
<213> Homo sapiens
<400> 355
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Asp Tyr
20 25 30
Gly Leu Ser Trp Val Arg His Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Gly Ile Asn Trp Asn Gly Gly Arg Thr Ala Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr His Cys
85 90 95
Ala Arg Ala Arg Gly Pro Ser Glu Gln Tyr Tyr Asp Leu Leu Thr Gly
100 105 110
Tyr Tyr Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val
115 120 125
Ser Ser
130
<210> 356
<211> 122
<212> PRT
<213> Homo sapiens
<400> 356
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val His Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Ala Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Arg Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Gln Met Gly Pro Leu Gly Ser Thr Ser Ser Ala Ala Asp Tyr Trp
100 105 110
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 357
<211> 130
<212> PRT
<213> Homo sapiens
<400> 357
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Asp Ile Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Met Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Arg Asn Thr Ser Ile Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Arg Glu Ala Arg Tyr Phe Asp Trp Ile Phe Glu Gly Ser Asp Tyr
100 105 110
Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val
115 120 125
Ser Ser
130
<210> 358
<211> 124
<212> PRT
<213> Homo sapiens
<400> 358
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Ser Ser Ser
20 25 30
Glu Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser His Ile Ser Ser Ser Gly Ser Ile Ile Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Arg Ser Tyr Arg Ser Ser Trp Tyr Tyr Tyr Tyr Gly Met Asp
100 105 110
Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 359
<211> 129
<212> PRT
<213> Homo sapiens
<400> 359
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Ile Phe Gly Asp Tyr
20 25 30
Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Gly Phe Ile Arg Gly Lys Ala Tyr Asp Gly Thr Thr Glu Tyr Ala Ala
50 55 60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Tyr Ile
65 70 75 80
Ala His Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
85 90 95
Tyr Cys Ile Arg Asp Tyr Asp Phe Trp Gly Gly Tyr Tyr Tyr His Pro
100 105 110
Leu Arg Ala Phe Asp Ile Trp Gly Arg Gly Thr Met Val Thr Val Ser
115 120 125
Ser
<210> 360
<211> 119
<212> PRT
<213> Homo sapiens
<400> 360
Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln
1 5 10 15
Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser
20 25 30
Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu
35 40 45
Trp Leu Ala Leu Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Ser Pro Ser
50 55 60
Leu Lys Ser Arg Leu Ser Ile Thr Lys Asp Thr Ser Lys Asn Gln Val
65 70 75 80
Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Gly Thr Tyr Tyr
85 90 95
Cys Ala Arg His Gln Ile Val Val Leu Phe Asp Met Trp Gly Gln Gly
100 105 110
Thr Arg Val Thr Val Ser Ser
115
<210> 361
<211> 122
<212> PRT
<213> Homo sapiens
<400> 361
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr
20 25 30
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ile Thr Tyr Tyr Tyr Asp Ser Ser Gly Tyr Trp Trp Asp Asp Trp
100 105 110
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 362
<211> 126
<212> PRT
<213> Homo sapiens
<400> 362
Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser
20 25 30
Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu
35 40 45
Trp Ile Gly Thr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser
50 55 60
Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Lys Gln Phe
65 70 75 80
Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
85 90 95
Cys Ala Gly Glu Glu Val Arg Gly Val Lys Leu Tyr Tyr Tyr Tyr Ala
100 105 110
Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 363
<211> 119
<212> PRT
<213> Homo sapiens
<400> 363
Glu Val Gln Leu Val Glu Ser Gly Gly Arg Leu Val Leu Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Val Tyr
20 25 30
Glu Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu
35 40 45
Ser Tyr Ile Gly Thr Ser Gly Ser Pro Ile Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Arg Asp Arg Gly Trp Asn Tyr Gly Leu Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 364
<211> 123
<212> PRT
<213> Homo sapiens
<400> 364
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Leu Ile Ser Ser Asp Gly Gly Asn Lys Phe Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Val Pro Thr Thr Val Thr Ala Phe Thr Val Phe Thr Tyr
100 105 110
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 365
<211> 121
<212> PRT
<213> Homo sapiens
<400> 365
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Asn Tyr
20 25 30
Ala Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Asn Asn Lys Asp Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Val Pro Val Met Val Arg Gly Val Tyr Phe Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 366
<211> 119
<212> PRT
<213> Homo sapiens
<400> 366
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Asp Ile Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Met Asn Pro Asn Ser Gly His Thr Gly Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Arg Asn Thr Ser Ile Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Tyr Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Tyr Gly Leu Thr Tyr Tyr Met Asp Val Trp Gly Lys Gly
100 105 110
Thr Thr Val Thr Val Ser Ser
115
<210> 367
<211> 123
<212> PRT
<213> Homo sapiens
<400> 367
Gln Val Gln Leu Ala Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ala Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Asp Ile Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Met Asn Pro Asn Ser Gly Asn Ala Gly Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Met Arg Ser Gly Trp Pro Thr His Gly Arg Pro Asp Asp Phe
100 105 110
Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 368
<211> 124
<212> PRT
<213> Homo sapiens
<400> 368
Glu Val Gln Leu Leu Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asn Tyr
20 25 30
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Asn Glu Arg Ile Thr Met Leu Val Val Val Thr Leu Phe Asp
100 105 110
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 369
<211> 124
<212> PRT
<213> Homo sapiens
<400> 369
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Gly Asn
20 25 30
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
65 70 75 80
Gln Met Asn Ser Pro Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Asp Pro Ser Ala Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Gly Asp
100 105 110
Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 370
<211> 123
<212> PRT
<213> Homo sapiens
<400> 370
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Tyr
20 25 30
Val Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Ser Ser Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Ile Asp Ser Gly Tyr Asp Pro Thr Pro Val Phe Asp Tyr
100 105 110
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 371
<211> 123
<212> PRT
<213> Homo sapiens
<400> 371
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly
1 5 10 15
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser
20 25 30
Asn Trp Trp Thr Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp
35 40 45
Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu
50 55 60
Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser
65 70 75 80
Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ser Arg Trp Gly Asp Tyr Phe Asp Ser Ser Gly Ala Tyr Asp Ser
100 105 110
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 372
<211> 127
<212> PRT
<213> Homo sapiens
<400> 372
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Cys Ile Ser Ser Ser Ser Ser Phe Ile Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Pro Val Trp Val Asp Gly Glu Leu Leu Ser Gly Gly Ile
100 105 110
Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 373
<211> 129
<212> PRT
<213> Homo sapiens
<400> 373
Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Arg Ser Ser
20 25 30
Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu
35 40 45
Trp Ile Ala Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Ser Ser
50 55 60
Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe
65 70 75 80
Ser Leu Lys Val Asn Ser Met Thr Ala Ala Asp Thr Ala Val Tyr Tyr
85 90 95
Cys Ala Ile Leu Trp Arg Gly Ser Ser Trp Ala Asp Arg His Tyr Tyr
100 105 110
Tyr Tyr Ser Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser
115 120 125
Ser
<210> 374
<211> 117
<212> PRT
<213> Homo sapiens
<400> 374
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Leu Ile Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser Ala
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Leu Gly Arg Gly Leu Asp Pro Trp Gly Gln Gly Thr Leu
100 105 110
Val Thr Val Ser Ser
115
<210> 375
<211> 118
<212> PRT
<213> Homo sapiens
<400> 375
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr
20 25 30
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Gly Ile Ile Ser Ser Ser Gly Gly Ala Thr Tyr Asn Ala Asp Ser
50 55 60
Val Arg Gly Arg Phe Thr Thr Ser Arg Asp Asn Ser Lys Asn Ile Leu
65 70 75 80
Tyr Leu Gln Met Asn Ser Leu Arg Gly Glu Asp Thr Ala Val Tyr Tyr
85 90 95
Cys Val Lys Gly Leu Phe Asp Trp Phe Pro Leu Trp Gly Gln Gly Thr
100 105 110
Met Val Thr Val Ser Ser
115
<210> 376
<211> 122
<212> PRT
<213> Homo sapiens
<400> 376
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln
1 5 10 15
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Ala Ser Ile Ser Ser Gly
20 25 30
Ser Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu
35 40 45
Trp Ile Gly Arg Ile Tyr Thr Ser Gly Asn Thr Asn Tyr Asn Pro Ser
50 55 60
Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe
65 70 75 80
Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
85 90 95
Cys Ala Thr Gly Tyr Ile Gly Thr Tyr Tyr Tyr Tyr Met Asp Val Trp
100 105 110
Gly Lys Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 377
<211> 123
<212> PRT
<213> Homo sapiens
<400> 377
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Lys Val Ser Ser Ile Thr Ser Leu Leu Gly Tyr Tyr Phe Asp Ser
100 105 110
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 378
<211> 117
<212> PRT
<213> Homo sapiens
<400> 378
Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Gly Thr Ser
20 25 30
Gly Met Cys Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu
35 40 45
Trp Leu Ala Arg Ile Asp Trp Asp Asp Asp Lys Tyr Tyr Ser Thr Ser
50 55 60
Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val
65 70 75 80
Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr
85 90 95
Cys Ala Arg Gly Val Val Thr Tyr Asp Tyr Trp Gly Gln Gly Thr Leu
100 105 110
Val Thr Val Ser Ser
115
<210> 379
<211> 119
<212> PRT
<213> Homo sapiens
<400> 379
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Asp Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Ser Asn Arg Tyr Tyr Ala Ala Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Val Tyr Phe Cys
85 90 95
Ala Arg Gly Asp Gly Tyr Arg Ser Gln Phe Asp Pro Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 380
<211> 120
<212> PRT
<213> Homo sapiens
<400> 380
Gln Ile Thr Phe Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Glu
1 5 10 15
Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Val Ser Thr Ser
20 25 30
Gly Glu Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu
35 40 45
Trp Leu Ala Val Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Ser Pro Ser
50 55 60
Leu Lys Ser Arg Leu Thr Ile Thr Arg Asp Thr Ser Lys Asn Gln Val
65 70 75 80
Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr
85 90 95
Cys Ala His Arg Leu Trp Phe Arg Asp Ala Phe Asp Ile Trp Gly Gln
100 105 110
Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 381
<211> 128
<212> PRT
<213> Homo sapiens
<400> 381
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr
20 25 30
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Gly Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Glu Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Val Glu Gly Asp Trp Leu Leu Gly Gly Pro Tyr Tyr His Tyr
100 105 110
Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 382
<211> 122
<212> PRT
<213> Homo sapiens
<400> 382
Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser
20 25 30
Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Asn Gly Leu Glu
35 40 45
Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser
50 55 60
Leu Lys Gly Arg Val Ser Ile Ser Val Asp Thr Ser Lys Asn Gln Phe
65 70 75 80
Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
85 90 95
Cys Ala Arg Ile Leu Val Ile Phe Thr Leu Asn Trp Phe Asp Pro Trp
100 105 110
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 383
<211> 119
<212> PRT
<213> Homo sapiens
<400> 383
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile Tyr
20 25 30
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Gln Trp Val
35 40 45
Ala Asn Ile Lys Gln Asp Ala Ser Glu Lys Tyr Tyr Val Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Leu Gly Gly Ser Ser Trp His Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 384
<211> 131
<212> PRT
<213> Homo sapiens
<400> 384
Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Pro Ile Ser Ser Ser
20 25 30
Arg Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu
35 40 45
Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser
50 55 60
Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe
65 70 75 80
Ser Leu Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
85 90 95
Cys Ala Arg His Asp Gly Ser Gly Glu Met Asp Thr Ile Thr Trp Gly
100 105 110
Pro Ile Tyr Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr
115 120 125
Val Ser Ser
130
<210> 385
<211> 120
<212> PRT
<213> Homo sapiens
<400> 385
Gln Ile Thr Phe Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Glu
1 5 10 15
Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Val Ser Thr Ser
20 25 30
Gly Glu Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu
35 40 45
Trp Leu Ala Val Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Ser Pro Ser
50 55 60
Leu Lys Ser Arg Leu Thr Ile Thr Arg Asp Thr Ser Lys Asn Gln Val
65 70 75 80
Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr
85 90 95
Cys Ala His Arg Leu Trp Phe Arg Asp Ala Phe Asp Ile Trp Gly Gln
100 105 110
Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 386
<211> 119
<212> PRT
<213> Homo sapiens
<400> 386
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Gly Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met
35 40 45
Gly Trp Ile Asn Val Gly Asn Gly Asn Thr Lys Tyr Ser Gln Arg Phe
50 55 60
Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Met Gly Pro Ser Ala Phe Ser Trp Leu Asp Pro Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 387
<211> 121
<212> PRT
<213> Homo sapiens
<400> 387
Gln Val Gln Leu Ala Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ser Thr Ser Gly Ser Tyr Tyr Tyr Gly Met Asp Val Trp Gly
100 105 110
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 388
<211> 123
<212> PRT
<213> Homo sapiens
<400> 388
Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln
1 5 10 15
Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Asn Thr Ser
20 25 30
Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu
35 40 45
Trp Leu Ala Leu Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser
50 55 60
Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val
65 70 75 80
Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr
85 90 95
Cys Ala His Arg Pro Pro Ser Tyr His Gly Trp Cys Tyr Phe Asp Tyr
100 105 110
Trp Gly Gln Gly Asn Leu Val Thr Val Ser Ser
115 120
<210> 389
<211> 117
<212> PRT
<213> Homo sapiens
<400> 389
Gln Val Gln Val Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Lys Asn Tyr
20 25 30
Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Ile Ser Ala Tyr Thr Gly Asn Thr Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Met Thr Met Thr Thr Asp Thr Ser Thr Gly Thr Gly Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Val Gln Arg Arg Arg Leu Asp Tyr Trp Gly Gln Gly Thr Leu
100 105 110
Val Ile Val Ser Ser
115
<210> 390
<211> 123
<212> PRT
<213> Homo sapiens
<400> 390
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly His
20 25 30
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
35 40 45
Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys
50 55 60
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
65 70 75 80
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Pro Pro Gln Ala Ala Arg Ile His Tyr Tyr Tyr Tyr Met Asp Val
100 105 110
Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 391
<211> 119
<212> PRT
<213> Homo sapiens
<400> 391
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr
20 25 30
Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
35 40 45
Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Thr Tyr Asn Pro Ser Phe
50 55 60
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Leu Thr Thr Ala Phe
65 70 75 80
Leu His Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Ile Tyr Tyr Cys
85 90 95
Ala Arg Arg Phe Tyr Gly Pro Ser Ser Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Ile Val Ser Ser
115
<210> 392
<211> 125
<212> PRT
<213> Homo sapiens
<400> 392
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Ala
1 5 10 15
Ser Met Asn Ile Ser Cys Lys Ala Ser Gly Tyr Asn Phe Asn Asn Asn
20 25 30
Tyr Ile Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Val Val Asn Pro Thr Gly Gly Gly Thr Ala Tyr Ala Gln Gly Phe
50 55 60
Gln Asp Arg Val Thr Ile Thr Ser Asp Thr Pro Arg Asn Thr Val Tyr
65 70 75 80
Leu Gly Val Thr Gly Leu His Ser Glu Asp Thr Ala Val Tyr Phe Cys
85 90 95
Ala Arg Gly Gly Glu Trp Arg Ile Val Pro Gly Gly Arg Asp Tyr Phe
100 105 110
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala
115 120 125
<210> 393
<211> 131
<212> PRT
<213> Homo sapiens
<400> 393
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys Ile Ser Cys Lys Gly Phe Gly Tyr Asn Phe Thr Asn Tyr
20 25 30
Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
35 40 45
Gly Ile Ile Tyr Pro Gly Asp Ser Glu Thr Arg Asn Ser Pro Ser Phe
50 55 60
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Met Ser Thr Ala Tyr
65 70 75 80
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
85 90 95
Ala Arg Leu Gly Val Ser Lys Tyr Cys Ser Gly Gly Arg Cys Leu Ser
100 105 110
Gly Gly Ser Asn Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr
115 120 125
Val Ser Ser
130
<210> 394
<211> 118
<212> PRT
<213> Homo sapiens
<400> 394
Glu Val His Leu Val Gly Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn
20 25 30
Phe Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ile Ile His Asn Gly Gly Asp Ser Tyr Tyr Thr Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
65 70 75 80
Gln Met Asn Asn Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Ser Ser Ser Trp Leu Arg Gly Ala Phe Asp Ile Trp Gly Gln Gly Thr
100 105 110
Met Val Thr Val Ser Ser
115
<210> 395
<211> 123
<212> PRT
<213> Homo sapiens
<400> 395
Gln Met Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Thr
1 5 10 15
Ser Val Lys Val Ser Cys Lys Thr Ser Gly Phe Thr Phe Thr Ser Ser
20 25 30
Ala Ile Gln Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Ile
35 40 45
Gly Trp Ile Val Val Gly Ser Gly Asn Thr Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Glu Arg Val Thr Ile Thr Arg Asp Met Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ala Pro His Cys Asn Arg Thr Ser Cys Tyr Asp Ala Phe Asp Leu
100 105 110
Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120
<210> 396
<211> 128
<212> PRT
<213> Homo sapiens
<400> 396
Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Thr Phe Gly Asp Tyr
20 25 30
Thr Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala
50 55 60
Ser Val Ile Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile
65 70 75 80
Ala Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr
85 90 95
Tyr Cys Ser Arg Val Arg Gly Ser Phe Tyr Gly Ser Val Gly Lys Asn
100 105 110
Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 397
<211> 123
<212> PRT
<213> Homo sapiens
<400> 397
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Tyr
20 25 30
Val Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Ser Ser Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Ile Asp Ser Gly Tyr Asp Pro Thr Pro Val Phe Asp Tyr
100 105 110
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 398
<211> 122
<212> PRT
<213> Homo sapiens
<400> 398
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr
20 25 30
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile Ile Pro Ile Phe Gly Ala Ala Asn Tyr Ala Gln Asn Phe
50 55 60
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Gly Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Arg Phe Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Thr Ser His Tyr Asp Ser Ser Gly Ser Tyr Phe Glu Tyr Trp
100 105 110
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 399
<211> 122
<212> PRT
<213> Homo sapiens
<400> 399
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Thr Tyr
20 25 30
Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
35 40 45
Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe
50 55 60
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65 70 75 80
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
85 90 95
Ala Arg Arg Arg Gly Gly Ile Gly Ile Glu Tyr Gly Met Asp Val Trp
100 105 110
Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 400
<211> 125
<212> PRT
<213> Homo sapiens
<400> 400
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Asp Ile Ser Tyr Asp Gly Ser Glu Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Tyr Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Asp Phe Gly Gly Asp Asn Thr Ala Met Val Glu Tyr Phe Phe
100 105 110
Asp Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 401
<211> 122
<212> PRT
<213> Homo sapiens
<400> 401
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Gly
20 25 30
Ser Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu
35 40 45
Cys Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Ser Asn Tyr Asn Pro Ser
50 55 60
Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe
65 70 75 80
Ser Leu Lys Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
85 90 95
Cys Ala Gly Ser Pro Val Pro Pro Thr Ile Val Gly Ala Ser Tyr Trp
100 105 110
Gly Gln Gly Thr Leu Val Thr Asp Ser Ser
115 120
<210> 402
<211> 120
<212> PRT
<213> Homo sapiens
<400> 402
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr
20 25 30
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Thr Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Arg Gly Asn Tyr Leu Thr Phe Phe Asp Ser Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 403
<211> 127
<212> PRT
<213> Homo sapiens
<400> 403
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Val Ser Ser Asn
20 25 30
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Gly Asp Asn Ser Lys Asn Thr Leu Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Val Asp Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Asp Pro Gly Ser Arg Tyr Ser Gly Gly Trp Tyr Asp Tyr Tyr Tyr
100 105 110
Ala Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 404
<211> 116
<212> PRT
<213> Homo sapiens
<400> 404
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Pro Thr Tyr
20 25 30
Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
35 40 45
Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Gly Pro Ser Phe
50 55 60
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65 70 75 80
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
85 90 95
Ala Arg Arg Asp Thr Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 405
<211> 123
<212> PRT
<213> Homo sapiens
<400> 405
Gln Met Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Thr
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Ser Ser
20 25 30
Ala Val Gln Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Ile
35 40 45
Gly Trp Ile Ala Val Gly Ser Gly Asn Thr Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Glu Arg Val Ser Ile Thr Arg Asp Met Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ala Pro Tyr Cys Ser Arg Thr Ser Cys His Asp Ala Phe Asp Ile
100 105 110
Trp Gly Gln Gly Thr Lys Val Thr Val Ser Ser
115 120
<210> 406
<211> 125
<212> PRT
<213> Homo sapiens
<400> 406
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Phe Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Phe Tyr Cys
85 90 95
Ala Lys Asp Leu Pro Pro Tyr Ala Ser Gly Trp Tyr Glu Gly Gly Phe
100 105 110
Asp Tyr Trp Gly Arg Gly Thr Gln Val Thr Val Ser Ser
115 120 125
<210> 407
<211> 120
<212> PRT
<213> Homo sapiens
<400> 407
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Val Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Thr Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe
65 70 75 80
Leu Gln Met Ile Gly Leu Arg Glu Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Gln Gly Arg Gly Gly Tyr Tyr Ser Pro Phe Asp Asp Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 408
<211> 124
<212> PRT
<213> Homo sapiens
<400> 408
Gln Val Thr Leu Lys Glu Ser Gly Pro Val Leu Val Lys Pro Thr Glu
1 5 10 15
Thr Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Asn Ala
20 25 30
Arg Met Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu
35 40 45
Trp Leu Ala His Ile Phe Ser Gly Asp Glu Lys Ser Tyr Ser Thr Ser
50 55 60
Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val
65 70 75 80
Val Leu Thr Met Thr Asn Met Asp Pro Leu Asp Thr Ala Thr Tyr Tyr
85 90 95
Cys Ala Arg Thr Thr Trp Gly Thr Trp Ile Gln Ala Trp Tyr Phe Asp
100 105 110
Ile Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 409
<211> 124
<212> PRT
<213> Homo sapiens
<400> 409
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Trp Phe Asp Gly Ser Asn Lys His Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu Gly Asp Phe Trp Ser Gly Tyr Tyr Thr Gly Trp Phe Asp
100 105 110
Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 410
<211> 124
<212> PRT
<213> Homo sapiens
<400> 410
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Asp Leu Thr Ile Val Val Ile Pro Ala Ala Pro Asn Phe Asp
100 105 110
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 411
<211> 129
<212> PRT
<213> Homo sapiens
<400> 411
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Phe Ile Ser Gly Thr Gly Asp Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Asp Gln Ala Arg Val Gln Asp Tyr Ile Trp Gly Ser Tyr Arg
100 105 110
Ser Tyr Gly Met Asp Val Trp Gly Leu Gly Thr Thr Val Thr Val Ser
115 120 125
Ser
<210> 412
<211> 121
<212> PRT
<213> Homo sapiens
<400> 412
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Gly Ile Ser Trp Asn Ser Gly Thr Ile Gly Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Lys Asp Ile Ile Arg Gln Gly Glu Asp Gly Met Asp Val Trp Gly
100 105 110
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 413
<211> 123
<212> PRT
<213> Homo sapiens
<400> 413
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Gly Ser Phe
20 25 30
Asp Ile Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Arg Met Asn Ser Asn Ser Gly Asn Thr Ala Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Asn Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys
85 90 95
Ala Arg Met Arg Ser Gly Trp Pro Thr His Gly Arg Pro Asp Asp Phe
100 105 110
Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 414
<211> 124
<212> PRT
<213> Homo sapiens
<400> 414
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr
20 25 30
Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Trp Leu Gln Leu Arg Ser Asp Tyr Tyr Tyr Phe Gly Met Asp
100 105 110
Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 415
<211> 119
<212> PRT
<213> Homo sapiens
<400> 415
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Phe Tyr
20 25 30
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Asn Ile Lys Gln Asp Gly Gly Glu Lys Tyr Tyr Val Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Leu Ser Gly Ser Ser Trp Asp Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 416
<211> 114
<212> PRT
<213> Homo sapiens
<400> 416
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Val Ser Thr Asn
20 25 30
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Asp Tyr Arg Asp Trp Ile Trp Gly Gln Gly Thr Leu Val Thr Val
100 105 110
Ser Ser
<210> 417
<211> 129
<212> PRT
<213> Homo sapiens
<400> 417
Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln
1 5 10 15
Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser
20 25 30
Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu
35 40 45
Trp Leu Ala Leu Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Ser Pro Ser
50 55 60
Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val
65 70 75 80
Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr
85 90 95
Cys Ala His Asn Arg Phe Gln Tyr Cys Ser Ser Thr Thr Cys Tyr Thr
100 105 110
Leu Leu Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
115 120 125
Ser
<210> 418
<211> 121
<212> PRT
<213> Homo sapiens
<400> 418
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Ala Leu Phe Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Pro Tyr Thr Gly Ser Tyr Lys Ser Tyr Met Asp Val Trp Gly
100 105 110
Lys Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 419
<211> 126
<212> PRT
<213> Homo sapiens
<400> 419
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Phe Tyr Cys
85 90 95
Ala Arg Gly Asp Gly Asp Val Tyr Asn Phe Leu Leu Val Arg Asn Trp
100 105 110
Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 420
<211> 121
<212> PRT
<213> Homo sapiens
<400> 420
Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser
20 25 30
Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu
35 40 45
Trp Ile Gly Ser Phe Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser
50 55 60
Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe
65 70 75 80
Ser Leu Asn Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Ser
85 90 95
Cys Ala Ser Leu Trp Phe Gly Asp Leu Tyr Ser Phe Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 421
<211> 119
<212> PRT
<213> Homo sapiens
<400> 421
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Asp Ser Ala Phe Thr Phe Ser Ser Phe
20 25 30
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Phe Tyr Leu Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Leu Gly Arg Ser Ser Trp Asn Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 422
<211> 125
<212> PRT
<213> Homo sapiens
<400> 422
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Gly
20 25 30
Ser Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu
35 40 45
Trp Ile Gly Arg Ile Tyr Thr Ser Gly Ser Thr Thr Tyr Asn Pro Ser
50 55 60
Leu Lys Ser Arg Val Thr Ile Ser Val Asn Thr Ser Lys Asn Gln Phe
65 70 75 80
Ser Leu Asn Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
85 90 95
Cys Ala Arg Val Gly Gly Ile Ser Pro Tyr Tyr Tyr Tyr Tyr Tyr Met
100 105 110
Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 423
<211> 123
<212> PRT
<213> Homo sapiens
<400> 423
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Asp Ile Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Met Asn Pro Asn Ser Gly Asn Ala Gly Tyr Gly Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Arg Asn Thr Ser Ile Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Met Arg Ser Gly Trp Pro Thr His Gly Arg Pro Asp Asp Tyr
100 105 110
Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 424
<211> 122
<212> PRT
<213> Homo sapiens
<400> 424
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly
20 25 30
Gly Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu
35 40 45
Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser
50 55 60
Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe
65 70 75 80
Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
85 90 95
Cys Ala Ser Ala Lys Leu Val Ala Thr Ile Ser Tyr Phe Asp Tyr Trp
100 105 110
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 425
<211> 119
<212> PRT
<213> Homo sapiens
<400> 425
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr
20 25 30
Tyr Trp Asn Trp Leu Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
35 40 45
Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys
50 55 60
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
65 70 75 80
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Val Gly Gly Tyr Tyr Tyr Tyr Tyr Met Asp Val Trp Gly Lys Gly
100 105 110
Thr Thr Val Thr Val Ser Ser
115
<210> 426
<211> 115
<212> PRT
<213> Homo sapiens
<400> 426
Glu Val Arg Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr
20 25 30
Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Ala Thr Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ser Lys Asn Ser Leu Val
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Pro Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr
100 105 110
Val Ser Ser
115
<210> 427
<211> 131
<212> PRT
<213> Homo sapiens
<400> 427
Gln Gly Gln Leu Val Gln Ser Gly Gly Asp Val Val Gln Pro Gly Lys
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asn Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Asn Asp Gly Ser Asn Glu Lys Tyr Val Asp Ser Val
50 55 60
Lys Gly Arg Phe Ser Leu Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr
65 70 75 80
Leu Asp Met His Ser Leu Arg Pro Glu Asp Thr Ala Ile Tyr Tyr Cys
85 90 95
Ala Arg Asp Arg Ser Asn Leu Glu Arg Leu Val Met Thr Phe Gly Gly
100 105 110
Ile Ile Ala Gly Ala Phe Asp Ile Trp Gly Gln Gly Ala Arg Val Thr
115 120 125
Val Ser Ser
130
<210> 428
<211> 121
<212> PRT
<213> Homo sapiens
<400> 428
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Ile Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Val Asn Ser Gly Ser Tyr Tyr Ser Tyr Phe Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 429
<211> 123
<212> PRT
<213> Homo sapiens
<400> 429
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly
1 5 10 15
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser
20 25 30
Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp
35 40 45
Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu
50 55 60
Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser
65 70 75 80
Leu Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ser Arg Trp Gly Asp Tyr Phe Asp Ser Ser Gly Ala Tyr Asp Ser
100 105 110
Trp Gly Gln Gly Thr Leu Leu Thr Val Ser Ser
115 120
<210> 430
<211> 118
<212> PRT
<213> Homo sapiens
<400> 430
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Lys
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Trp Tyr Asp Gly Asn Asn Lys Phe Tyr Val Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Met Glu Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Lys Gly Pro Leu Trp Arg Phe Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Leu Val Thr Val Ser Ser
115
<210> 431
<211> 112
<212> PRT
<213> Homo sapiens
<400> 431
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Val Ser Ser Asn
20 25 30
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Glu Ser Thr Gln Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
100 105 110
<210> 432
<211> 127
<212> PRT
<213> Homo sapiens
<400> 432
Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser
20 25 30
Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu
35 40 45
Trp Ile Gly Ser Val Tyr Tyr Ile Gly Ser Thr Tyr Tyr Asn Pro Ser
50 55 60
Leu Lys Ser Arg Val Thr Met Ser Val Asp Thr Ser Lys Asn Gln Phe
65 70 75 80
Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
85 90 95
Cys Ala Arg Ala Pro Phe Gln Leu Leu Asp Lys Tyr Tyr Phe Phe Tyr
100 105 110
Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 433
<211> 116
<212> PRT
<213> Homo sapiens
<400> 433
Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Ile Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Val Ser Ser Asn
20 25 30
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ile Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Ser Ile Ser Arg Asp Asn Ser Asn Asn Thr Leu Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala
85 90 95
Arg His Ile Pro Ala Trp Gly Tyr Lys Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 434
<211> 124
<212> PRT
<213> Homo sapiens
<400> 434
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Ser Tyr
20 25 30
Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Ile Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Leu Gly Ser Gly Ile Thr Leu Asp Asn Asp Ala Phe Asp
100 105 110
Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120
<210> 435
<211> 122
<212> PRT
<213> Homo sapiens
<400> 435
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr
20 25 30
Ala Ile Ile Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile Ile Pro Ile Phe Gly Thr Thr Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65 70 75 80
Val Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ile Gly His Phe Asp Ser Ser Gly Tyr Tyr Leu Asp Tyr Trp
100 105 110
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 436
<211> 123
<212> PRT
<213> Homo sapiens
<400> 436
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Ser Tyr
20 25 30
Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Val Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Asp Phe Gly Ser Gly Ile Val Gly Ala Thr Gly Phe Asp Phe
100 105 110
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 437
<211> 129
<212> PRT
<213> Homo sapiens
<400> 437
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr His Cys
85 90 95
Ala Arg Arg Arg Ser Ser Ser Arg Tyr Ser Ser Gly Trp Tyr Met Tyr
100 105 110
Tyr Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser
115 120 125
Ser
<210> 438
<211> 121
<212> PRT
<213> Homo sapiens
<400> 438
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asn Ser
20 25 30
Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
35 40 45
Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe
50 55 60
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65 70 75 80
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Ile Tyr Tyr Cys
85 90 95
Ala Thr His Arg Cys Ser Gly Gly Phe Cys Tyr Leu Ala Tyr Trp Gly
100 105 110
Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 439
<211> 124
<212> PRT
<213> Homo sapiens
<400> 439
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe Ser Ser Phe
20 25 30
Ala Leu His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Thr Val Ile Ser Asp Asp Gly Asn Asn Lys Tyr Tyr Val Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Ile Tyr Tyr Cys
85 90 95
Ala Arg Ala Ser Tyr Asn Ser Asn Trp Ser Ile Gly Glu Tyr Phe Arg
100 105 110
Asp Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 440
<211> 127
<212> PRT
<213> Homo sapiens
<400> 440
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr
20 25 30
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Leu Tyr Asp Gly Ser Asn Arg Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gln Gly Gly Leu Tyr Cys Ser Gly Thr Asn Cys Trp Gly Gly
100 105 110
Tyr Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 441
<211> 119
<212> PRT
<213> Homo sapiens
<400> 441
Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln
1 5 10 15
Thr Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Thr Ser
20 25 30
Gly Val Gly Val Gly Cys Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu
35 40 45
Trp Leu Ala Leu Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Ser Pro Ser
50 55 60
Leu Lys Ser Arg Leu Thr Ile Thr Arg Asp Thr Ser Lys Asn Gln Val
65 70 75 80
Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Gly Thr Tyr Phe
85 90 95
Cys Val His Arg His Val Ser Gly Ala Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 442
<211> 131
<212> PRT
<213> Homo sapiens
<400> 442
Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Ile Asn Thr Asn Thr Gly Asn Pro Thr Tyr Ala Gln Gly Phe
50 55 60
Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Asn Thr Ala Tyr
65 70 75 80
Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ala Arg Leu Leu Gly Tyr Cys Ser Ser Thr Ser Cys Tyr Thr
100 105 110
Ile Gly Trp Gly Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr
115 120 125
Val Ser Ser
130
<210> 443
<211> 118
<212> PRT
<213> Homo sapiens
<400> 443
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu Gly Gln Gly Thr Tyr Leu Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Leu Val Thr Val Ser Ser
115
<210> 444
<211> 126
<212> PRT
<213> Homo sapiens
<400> 444
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Glu Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Tyr Ile Ser Ser Ser Gly Ser Ala Ile Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu Ala Arg Ser Arg Tyr Phe Asp Trp Leu Pro Ser Tyr Tyr
100 105 110
Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 445
<211> 122
<212> PRT
<213> Homo sapiens
<400> 445
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg His
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Ala Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Pro Ser Pro Leu Val Leu Ile Thr Ser Ile Asp Tyr Trp
100 105 110
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 446
<211> 123
<212> PRT
<213> Homo sapiens
<400> 446
Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly
20 25 30
Thr Tyr Tyr Cys Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu
35 40 45
Trp Ile Gly Ser Thr Tyr Tyr Gly Gly Ser Thr Leu Tyr Asn Pro Ser
50 55 60
Leu Arg Gly Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe
65 70 75 80
Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
85 90 95
Cys Ala Arg Arg Gly Asn Tyr Tyr Asp Ser Lys Asn Trp Phe Asp Pro
100 105 110
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 447
<211> 121
<212> PRT
<213> Homo sapiens
<400> 447
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly
20 25 30
Gly Tyr Phe Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu
35 40 45
Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser
50 55 60
Leu Arg Ser Arg Ile Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe
65 70 75 80
Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
85 90 95
Cys Ala Arg Gly Gly Ser Gly Ser Tyr Ser Leu Phe Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 448
<211> 122
<212> PRT
<213> Homo sapiens
<400> 448
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Ser
20 25 30
Asp Leu His Trp Val Arg Gln Ala Thr Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Gly Thr Ala Gly Asp Thr Tyr Tyr Leu Gly Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Glu Asn Gly Lys Asn Ser Leu Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Ala Gly Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Val Leu Tyr Asp Ser Ser Gly Phe Tyr Asn Trp Phe Asp Pro Trp
100 105 110
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 449
<211> 126
<212> PRT
<213> Homo sapiens
<400> 449
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly
20 25 30
Gly Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu
35 40 45
Trp Ile Gly Tyr Ile Ser Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser
50 55 60
Leu Lys Ser Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe
65 70 75 80
Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
85 90 95
Cys Ala Arg Asp Leu Gly Asp Gly Tyr Asn Leu Arg Val Pro Ala Tyr
100 105 110
Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 450
<211> 118
<212> PRT
<213> Homo sapiens
<400> 450
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly
1 5 10 15
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser
20 25 30
Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp
35 40 45
Ile Gly Glu Ile Tyr His Gly Gly Ser Thr Asp Tyr Asn Pro Ser Leu
50 55 60
Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser
65 70 75 80
Leu Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Val Asp His Val Asn Val Arg Asp Tyr Trp Gly Pro Gly Thr
100 105 110
Leu Val Thr Val Ser Ser
115
<210> 451
<211> 128
<212> PRT
<213> Homo sapiens
<400> 451
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Ser Asn Ser Asn Ser Phe Ile Tyr Tyr Ala Asp Ser Met
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Val Asn Gly Asn Ser Asn Trp Asn Phe Gly Ser Tyr Tyr Tyr
100 105 110
Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 452
<211> 121
<212> PRT
<213> Homo sapiens
<400> 452
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr
20 25 30
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Tyr Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Ile His Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu Gly Gln Met Ala Ala Thr Thr Gly Ile Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 453
<211> 128
<212> PRT
<213> Homo sapiens
<400> 453
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala
20 25 30
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Gly Arg Ile Lys Gly Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala
50 55 60
Pro Val Lys Gly Arg Phe Thr Ile Ser Lys Asp Asp Ser Lys Asn Thr
65 70 75 80
Leu Tyr Leu Gln Met Ser Ser Leu Asn Thr Glu Asp Thr Ala Val Tyr
85 90 95
Trp Cys Thr Thr Leu Thr Tyr Tyr Tyr Asp Ser Ser Ala Tyr Leu Asn
100 105 110
Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120 125
<210> 454
<211> 121
<212> PRT
<213> Homo sapiens
<400> 454
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Gly Ile Ser Trp Asn Ser Asp Asn Ile Gly Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Ile Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Lys Gly Ile Tyr Tyr Asp Ile Phe Met Pro Leu Leu Asp Trp Gly
100 105 110
Arg Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 455
<211> 121
<212> PRT
<213> Homo sapiens
<400> 455
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Thr Ser Gly Asp Thr Ser Ser Ser Tyr
20 25 30
Thr Val Gly Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Tyr Ser Ala Gln Lys Phe
50 55 60
Gln Gly Arg Leu Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ser Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Val Val Ala Ala Thr Pro Gly Trp Phe Asp Pro Trp Gly
100 105 110
Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 456
<211> 124
<212> PRT
<213> Homo sapiens
<400> 456
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Gly Ser Tyr
20 25 30
Val Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Gln Trp Met
35 40 45
Gly Gly Ile Ile Pro Ile Phe Gly Lys Pro Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Trp Phe Gly Glu Leu Leu Lys Gly Thr Tyr Trp Phe Asp
100 105 110
Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 457
<211> 125
<212> PRT
<213> Homo sapiens
<400> 457
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr
20 25 30
Ser Ile Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Arg Ile Ile Pro Val Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Val Gly Val Ser Gly Phe Lys Ser Gly Ser Asn Trp Tyr Phe
100 105 110
Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 458
<211> 120
<212> PRT
<213> Homo sapiens
<400> 458
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val
35 40 45
Ser Arg Ile Asn Ser Asp Gly Ser Ser Thr Ser Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu Val Glu Gln Leu Ala His Met Val Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 459
<211> 123
<212> PRT
<213> Homo sapiens
<400> 459
Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Thr
20 25 30
Thr Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu
35 40 45
Trp Ile Ala Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser
50 55 60
Leu Lys Ser Arg Leu Thr Val Ser Val Asp Thr Ser Lys Asn Gln Phe
65 70 75 80
Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
85 90 95
Cys Ala Arg Gln Trp Lys Trp Phe Gly Glu Ala Trp Tyr Phe Asp Leu
100 105 110
Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 460
<211> 124
<212> PRT
<213> Homo sapiens
<400> 460
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Asn Ile Asn Gln Asp Gly Gly Glu Lys Tyr Tyr Val Asp Ser Val
50 55 60
Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Pro Tyr Asp Leu Tyr Gly Asp Tyr Gly Gly Thr Phe Asp
100 105 110
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 461
<211> 129
<212> PRT
<213> Homo sapiens
<400> 461
Gln Val Gln Leu Val Gln Ser Gly Ala Ala Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr
20 25 30
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile Val Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu Asn Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu Asp Tyr Tyr Gly Ser Gly Ser Leu Val Asp Pro Tyr Tyr
100 105 110
Tyr Tyr Arg Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser
115 120 125
Ser
<210> 462
<211> 122
<212> PRT
<213> Homo sapiens
<400> 462
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr
20 25 30
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Val Arg Asp Leu Ala Leu Phe Glu Val Val Ile Gln Gln Gly Val Trp
100 105 110
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 463
<211> 127
<212> PRT
<213> Homo sapiens
<400> 463
Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Arg
20 25 30
Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu
35 40 45
Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser
50 55 60
Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe
65 70 75 80
Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
85 90 95
Cys Ala Arg His Thr Val Asp Cys Gly Gly Asp Cys Phe Pro Asn Asp
100 105 110
Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120 125
<210> 464
<211> 130
<212> PRT
<213> Homo sapiens
<400> 464
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Ile Asn Pro Asn Ser Arg Gly Thr Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Val Tyr
65 70 75 80
Met Glu Leu Ser Arg Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Val Val Val Leu Gly Tyr Gly Arg Pro Asn Asn Tyr Tyr Asp
100 105 110
Gly Arg Asn Val Trp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val
115 120 125
Ser Ser
130
<210> 465
<211> 121
<212> PRT
<213> Homo sapiens
<400> 465
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Thr Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Asp Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Pro Arg Gly Gly Ser Tyr Gln Thr Cys Phe Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 466
<211> 122
<212> PRT
<213> Homo sapiens
<400> 466
Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser His
20 25 30
Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Ile Asn Thr Asn Thr Gly Asn Pro Met Tyr Ala Gln Gly Phe
50 55 60
Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Gly Ser Thr Ala Tyr
65 70 75 80
Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Trp Gly Pro Asp Tyr Gly Asp Tyr Ala Ser Asn Asp Tyr Trp
100 105 110
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 467
<211> 129
<212> PRT
<213> Homo sapiens
<400> 467
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Asp Asp Tyr
20 25 30
Asp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Gly Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr His Cys
85 90 95
Ala Val Ile Met Ser Pro Ile Pro Arg Tyr Ser Gly Tyr Asp Trp Ala
100 105 110
Gly Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser
115 120 125
Ser
<210> 468
<211> 117
<212> PRT
<213> Homo sapiens
<400> 468
Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr
20 25 30
Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Ile Asn Thr Asn Thr Gly Asn Pro Thr Tyr Ala Gln Asp Phe
50 55 60
Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr
65 70 75 80
Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Leu Val Gly Arg Ile Asp Pro Trp Gly Gln Gly Thr Leu
100 105 110
Val Thr Val Ser Ser
115
<210> 469
<211> 122
<212> PRT
<213> Homo sapiens
<400> 469
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr
20 25 30
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Ile Leu Asn Pro Gly Ala Gly Ser Thr Ser Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Ser Asp Thr Ser Thr Asn Thr Val Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Gln Gln Ile Val Pro His Ala Asp Gly Phe Asp Ile Trp
100 105 110
Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120
<210> 470
<211> 119
<212> PRT
<213> Homo sapiens
<400> 470
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Arg Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr
20 25 30
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile Ile Pro Val Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Phe
65 70 75 80
Met Glu Leu Asn Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ile Gly Ser Tyr Pro Glu Tyr Phe Gln His Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 471
<211> 121
<212> PRT
<213> Homo sapiens
<400> 471
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Gly Ile Ser Trp Asn Ser Gly Thr Ile Gly Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Lys Asp Ile Ile Arg Gln Gly Glu Asp Gly Met Asp Val Trp Gly
100 105 110
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 472
<211> 129
<212> PRT
<213> Homo sapiens
<400> 472
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Asn Ile Lys Glu Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Val Gly Gly Tyr Ser Gly Tyr Asp Leu Gly Phe Asp Tyr
100 105 110
Tyr Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser
115 120 125
Ser
<210> 473
<211> 126
<212> PRT
<213> Homo sapiens
<400> 473
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ala Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser Leu
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Asp Arg Thr Ala Val Phe Leu Phe Phe Gly Leu Gly Asp Ala
100 105 110
Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120 125
<210> 474
<211> 121
<212> PRT
<213> Homo sapiens
<400> 474
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser His
20 25 30
Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
35 40 45
Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe
50 55 60
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65 70 75 80
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
85 90 95
Ala Ser Ala Leu Arg Glu Arg Gly Val Gln Leu Trp Ser Val Trp Gly
100 105 110
Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 475
<211> 123
<212> PRT
<213> Homo sapiens
<400> 475
Glu Val Arg Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Ser Tyr
20 25 30
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Gln Trp Val
35 40 45
Ser Thr Ile Ser Val Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Asp Pro Ala Ser Gly Ile Val Gly Pro Thr His Phe Asp Tyr
100 105 110
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 476
<211> 121
<212> PRT
<213> Homo sapiens
<400> 476
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Thr Glu Leu
20 25 30
Ser Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met
35 40 45
Gly Gly Phe Asp Pro Glu Asp Ala Glu Thr Ile Tyr Ala Gln Gln Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Lys Ser Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Thr Gly Phe Ala Val Phe Gly Arg Ala Ala Val Pro Tyr Trp Gly
100 105 110
Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 477
<211> 127
<212> PRT
<213> Homo sapiens
<400> 477
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly
20 25 30
Asp Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu
35 40 45
Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser
50 55 60
Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val
65 70 75 80
Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
85 90 95
Cys Ala Arg Phe Arg Arg Ser Tyr Gly Ser Gly Ser Tyr Tyr Asn Ile
100 105 110
Ser Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 478
<211> 119
<212> PRT
<213> Homo sapiens
<400> 478
Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg His
20 25 30
Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Ile Asn Thr Asn Thr Gly Asn Pro Thr Tyr Ala Gln Gly Phe
50 55 60
Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr
65 70 75 80
Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Val Arg Glu Tyr Gly Ser Gly His Pro Leu Pro Ile Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 479
<211> 118
<212> PRT
<213> Homo sapiens
<400> 479
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Ser Val Ser Gly Gly Ser Ile Arg Ser Tyr
20 25 30
Phe Trp Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
35 40 45
Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Lys Pro Ser Phe Lys
50 55 60
Ser Arg Val Thr Ile Ser Leu Asp Thr Ser Lys Asn Gln Ile Ser Leu
65 70 75 80
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Ala Thr Trp Leu Arg Asp Ala Phe Gly Ile Trp Gly Gln Gly Thr
100 105 110
Met Val Thr Val Ser Ser
115
<210> 480
<211> 123
<212> PRT
<213> Homo sapiens
<400> 480
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Arg Val Ser Cys Lys Ala Pro Gly Tyr Thr Phe Thr Thr Tyr
20 25 30
Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Ile Ile Asn Pro Ser Ala Gly Ser Thr Thr Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Phe His Val Pro Ala Ala Leu Arg Asn Trp Phe Asp Pro
100 105 110
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 481
<211> 125
<212> PRT
<213> Homo sapiens
<400> 481
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly
20 25 30
Gly Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu
35 40 45
Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser
50 55 60
Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe
65 70 75 80
Ser Leu Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
85 90 95
Cys Ala Arg Glu Ala Asn Asp Ser Gly Ser Phe Tyr Asn Gly Pro Phe
100 105 110
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 482
<211> 125
<212> PRT
<213> Homo sapiens
<400> 482
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly
20 25 30
Ser Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu
35 40 45
Trp Ile Gly Arg Ile Phe Thr Ser Gly Ser Thr Asn Tyr Asn Pro Ser
50 55 60
Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe
65 70 75 80
Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
85 90 95
Cys Ala Arg Gly Gly Leu Leu Trp Phe Gly Gly Ala Gly Asn Tyr Met
100 105 110
Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 483
<211> 123
<212> PRT
<213> Homo sapiens
<400> 483
Gln Val Gln Leu Ala Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Gly Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Asp Ile Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Met Asn Ser Asn Ser Gly Asn Ala Gly Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Met Arg Thr Gly Trp Pro Thr His Gly Arg Pro Asp Asp Phe
100 105 110
Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 484
<211> 124
<212> PRT
<213> Homo sapiens
<400> 484
Gln Val Gln Ile Gln Gln Trp Gly Ala Gly Val Leu Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly His
20 25 30
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
35 40 45
Gly Glu Ile Asn His Ser Gly Ser Thr Lys Tyr Asn Pro Ser Leu Lys
50 55 60
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
65 70 75 80
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Gly Pro Pro Val Thr Thr Phe Phe Val Phe Ser Leu Leu Phe Asp
100 105 110
Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 485
<211> 122
<212> PRT
<213> Homo sapiens
<400> 485
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Arg Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Gly Glu Trp Glu Leu Arg Gly Asn Ala Leu Asp Ile Trp
100 105 110
Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120
<210> 486
<211> 120
<212> PRT
<213> Homo sapiens
<400> 486
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Gly Met His Trp Val Arg Gln Ala Pro Asp Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu Gly Gln Trp Pro Asn Gln Ala Phe Asp Ile Trp Gly Gln
100 105 110
Gly Thr Met Val Thr Val Ser Ser
115 120
<210> 487
<211> 124
<212> PRT
<213> Homo sapiens
<400> 487
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser
20 25 30
Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu
35 40 45
Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Ser Tyr Tyr Ser Pro Ser
50 55 60
Leu Lys Ser Arg Val Thr Ile Ser Ala Asp Thr Ser Lys Asn Gln Phe
65 70 75 80
Ser Leu Asn Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
85 90 95
Cys Ala Ser Gly Pro Pro Tyr Met Ala Thr Phe Ser Tyr Tyr Phe Asp
100 105 110
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 488
<211> 124
<212> PRT
<213> Homo sapiens
<400> 488
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr
20 25 30
Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Cys Val
35 40 45
Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Pro Ile Arg Asp Gly Val Trp Gly Leu Asn Glu Asn Asp
100 105 110
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 489
<211> 125
<212> PRT
<213> Homo sapiens
<400> 489
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Ser Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ser Pro Pro Ala Ser Tyr Tyr Asn Pro Ser Thr Gly Tyr Phe
100 105 110
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 490
<211> 122
<212> PRT
<213> Homo sapiens
<400> 490
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser His
20 25 30
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Ser Asp Thr Ser Thr Ser Thr Val Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys
85 90 95
Ala Arg Asp Val Phe Trp Val Pro Ala Ala Ser Ser Phe Asp Tyr Trp
100 105 110
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 491
<211> 122
<212> PRT
<213> Homo sapiens
<400> 491
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Gln Glu Trp Phe Arg Glu Leu Phe Leu Phe Asp Tyr Trp
100 105 110
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 492
<211> 123
<212> PRT
<213> Homo sapiens
<400> 492
Gln Val Gln Leu Ala Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ala Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Asp Ile Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Met Asn Ser Asn Ser Gly Asn Ala Gly Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Met Arg Thr Gly Trp Pro Thr His Gly Arg Pro Asp Asp Phe
100 105 110
Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 493
<211> 125
<212> PRT
<213> Homo sapiens
<400> 493
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr
20 25 30
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
35 40 45
Gly Glu Ile Asn His Ser Gly Ser Ser Asn Tyr Asn Pro Ser Leu Lys
50 55 60
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
65 70 75 80
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Gly Trp Gly Trp Gly Ala Val Ala Gly Arg Ala Glu Tyr Tyr Phe
100 105 110
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 494
<211> 121
<212> PRT
<213> Homo sapiens
<400> 494
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Tyr Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ala Gln Gly Gly Asn Tyr Tyr Tyr Gly Met Asp Val Trp Gly
100 105 110
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 495
<211> 119
<212> PRT
<213> Homo sapiens
<400> 495
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly
20 25 30
Ser Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu
35 40 45
Trp Ile Gly Arg Val Tyr Ile Tyr Ser Ser Gly Ser Thr Asn Tyr Asn
50 55 60
Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn
65 70 75 80
Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val
85 90 95
Tyr Tyr Cys Ala Arg Gly Ala Ala Ser Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 496
<211> 126
<212> PRT
<213> Homo sapiens
<400> 496
Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser
20 25 30
Ser Asn Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu
35 40 45
Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser
50 55 60
Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe
65 70 75 80
Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
85 90 95
Cys Ala Arg Asp Pro Arg Val Val Val Thr Ala Arg Met Tyr Asn Trp
100 105 110
Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 497
<211> 128
<212> PRT
<213> Homo sapiens
<400> 497
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Leu Ser Ser Tyr
20 25 30
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
35 40 45
Gly Tyr Ile Tyr Asp Ser Gly Gly Ala Ser Arg Ser Thr Asn Tyr Asn
50 55 60
Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Arg Asn
65 70 75 80
Gln Leu Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val
85 90 95
Tyr Tyr Cys Ala Arg Asp Gln Arg Gln Phe Gln Leu Leu Gly Arg Phe
100 105 110
Gly Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 498
<211> 123
<212> PRT
<213> Homo sapiens
<400> 498
Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Thr
20 25 30
Thr Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu
35 40 45
Trp Ile Ala Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser
50 55 60
Leu Lys Ser Arg Leu Thr Val Ser Val Asp Thr Ser Lys Asn Gln Phe
65 70 75 80
Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
85 90 95
Cys Ala Arg Gln Trp Lys Trp Phe Gly Glu Ala Trp Tyr Phe Asp Leu
100 105 110
Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 499
<211> 125
<212> PRT
<213> Homo sapiens
<400> 499
Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr
20 25 30
Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Ile Asn Thr Asn Thr Gly Asn Pro Thr Tyr Ala Gln Gly Phe
50 55 60
Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Asn Thr Ala Phe
65 70 75 80
Leu His Ile Gly Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Gln Asp Ser Gly Tyr Pro Thr Tyr Tyr Tyr Tyr Tyr Met
100 105 110
Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 500
<211> 128
<212> PRT
<213> Homo sapiens
<400> 500
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Asp Met Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Met Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Arg Asn Thr Ser Ile Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Gly Ile Tyr Tyr Leu Val Arg Gly Phe Ile Ile Gly Tyr
100 105 110
Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 501
<211> 122
<212> PRT
<213> Homo sapiens
<400> 501
Glu Val Ala Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Ala
20 25 30
Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Gly Arg Ile Lys Ser Lys Ser Glu Gly Gly Thr Pro Glu Tyr Ala Ala
50 55 60
Pro Val Lys Gly Arg Phe Ile Ile Ser Arg Asp Asp Ser Thr Asn Ser
65 70 75 80
Leu His Leu Gln Met Asn Tyr Leu Arg Ile Glu Asp Thr Ala Val Tyr
85 90 95
Tyr Cys Thr Thr Gly Gly Tyr Ser Ser Tyr Ala Ala Ser Asp Tyr Trp
100 105 110
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 502
<211> 124
<212> PRT
<213> Homo sapiens
<400> 502
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Tyr Ile Ser Ser Arg Ser Ser Thr Ile Lys Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Val Asp Tyr Tyr Gly Ser Gly Ser Val Tyr Trp Tyr Phe Asp
100 105 110
Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 503
<211> 121
<212> PRT
<213> Homo sapiens
<400> 503
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Ala Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Phe Cys
85 90 95
Ala Lys Val Gly Trp Glu Leu Ser Ile Asp Ala Phe Asp Leu Trp Gly
100 105 110
Gln Gly Thr Met Val Thr Val Ser Ser
115 120
<210> 504
<211> 120
<212> PRT
<213> Homo sapiens
<400> 504
Gln Ile Thr Phe Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Glu
1 5 10 15
Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Val Ser Thr Ser
20 25 30
Gly Glu Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu
35 40 45
Trp Leu Ala Val Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Ser Pro Ser
50 55 60
Leu Lys Ser Arg Leu Thr Ile Thr Arg Asp Thr Ser Lys Asn Gln Val
65 70 75 80
Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr
85 90 95
Cys Ala His Arg Leu Trp Phe Arg Asp Ala Phe Asp Ile Trp Gly Gln
100 105 110
Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 505
<211> 120
<212> PRT
<213> Homo sapiens
<400> 505
Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln
1 5 10 15
Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser
20 25 30
Gly Met Cys Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu
35 40 45
Trp Leu Ala Arg Ile Asp Trp Asp Asp Asp Lys Tyr Tyr Ser Thr Ser
50 55 60
Leu Glu Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val
65 70 75 80
Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr
85 90 95
Cys Ala Arg Ile Gln Tyr Gln Leu Asn Gly Met Asp Val Trp Gly Gln
100 105 110
Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 506
<211> 130
<212> PRT
<213> Homo sapiens
<400> 506
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Ser Tyr
20 25 30
Asp Ile Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Val Asn Pro Asn Ser Gly His Thr Gly Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Arg Asn Thr Ser Val Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Phe Tyr Cys
85 90 95
Ala Arg Gly Arg Val Gly Tyr Val Gly Ser Gly Ser Arg Gly Tyr Tyr
100 105 110
Tyr Tyr Tyr Asp Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val
115 120 125
Ser Ser
130
<210> 507
<211> 124
<212> PRT
<213> Homo sapiens
<400> 507
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr
20 25 30
Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
35 40 45
Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe
50 55 60
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65 70 75 80
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
85 90 95
Ala Arg Pro Asp Tyr Ser Ser Gly Trp Phe Ser Tyr Trp Tyr Phe Asp
100 105 110
Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 508
<211> 119
<212> PRT
<213> Homo sapiens
<400> 508
Gln Val Gln Leu Val Gln Ser Gly Ser Ala Leu Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Ile Asn Thr Asn Thr Gly Asn Pro Thr Tyr Ala Gln Gly Phe
50 55 60
Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr
65 70 75 80
Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Arg Ser Tyr Gly Leu Ser Leu Gly Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 509
<211> 120
<212> PRT
<213> Homo sapiens
<400> 509
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser His
20 25 30
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Ser
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu Ser Ala Asp Ile Ser Ser Arg Leu Asp Tyr Trp Gly Arg
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 510
<211> 120
<212> PRT
<213> Homo sapiens
<400> 510
Gln Ile Thr Phe Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Glu
1 5 10 15
Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Val Ser Thr Ser
20 25 30
Gly Glu Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu
35 40 45
Trp Leu Ala Val Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Ser Pro Ser
50 55 60
Leu Lys Ser Arg Leu Thr Ile Thr Arg Asp Thr Ser Lys Asn Gln Val
65 70 75 80
Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr
85 90 95
Cys Ala His Arg Leu Trp Phe Arg Asp Ala Phe Asp Ile Trp Gly Gln
100 105 110
Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 511
<211> 123
<212> PRT
<213> Homo sapiens
<400> 511
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Leu Ser Asp His
20 25 30
Tyr Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Gly Arg Thr Arg Asn Lys Ala Asn Ser Tyr Thr Thr Glu Tyr Ala Ala
50 55 60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ser
65 70 75 80
Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
85 90 95
Tyr Cys Ala Ser Val Ile Thr Phe Gly Gly Val Ile Val Arg Ser Tyr
100 105 110
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 512
<211> 122
<212> PRT
<213> Homo sapiens
<400> 512
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr
20 25 30
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile Ile Pro Val Phe Gly Thr Thr Asn Tyr Ala Gln Lys Leu
50 55 60
Gln Gly Arg Val Thr Ile Ser Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Val Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Val Ser Gly Tyr Gly Asp Tyr Gly Ala Tyr Ser Asp Tyr Trp
100 105 110
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 513
<211> 121
<212> PRT
<213> Homo sapiens
<400> 513
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Val Ala Ser Glu Phe Thr Phe Ser Ser Tyr
20 25 30
Trp Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Gly Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ser Val Ile Thr Phe Gly Gly Val Ile Val Arg Ser Tyr Trp Gly
100 105 110
Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 514
<211> 128
<212> PRT
<213> Homo sapiens
<400> 514
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr
20 25 30
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Gly Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Glu Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Val Glu Gly Asp Trp Leu Leu Gly Gly Pro Tyr Tyr His Tyr
100 105 110
Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 515
<211> 121
<212> PRT
<213> Homo sapiens
<400> 515
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Gly Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ala Asp Thr Met Val Arg Gly Thr Tyr Phe Glu Tyr Trp Gly
100 105 110
Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 516
<211> 120
<212> PRT
<213> Homo sapiens
<400> 516
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Leu Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Trp Ala Asn Gly Asn Arg Tyr Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Ile Ser Lys Asn Thr Leu Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys Ala
85 90 95
Arg Asp Tyr Cys Asn Gly Val Thr Cys Asn Ser Asn Tyr Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 517
<211> 115
<212> PRT
<213> Homo sapiens
<400> 517
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly
1 5 10 15
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser
20 25 30
Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp
35 40 45
Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu
50 55 60
Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser
65 70 75 80
Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Trp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr
100 105 110
Val Ser Ala
115
<210> 518
<211> 124
<212> PRT
<213> Homo sapiens
<400> 518
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe His Asn Tyr
20 25 30
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Phe Ile Pro Ile Leu Gly Thr Thr Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Val Glu Gly Glu Gly Val Asp Ser Tyr Tyr Tyr Gly Met Asp
100 105 110
Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 519
<211> 121
<212> PRT
<213> Homo sapiens
<400> 519
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Gly Ile Ser Trp Asn Ser Gly Thr Ile Gly Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Lys Asp Ile Ile Arg Gln Gly Glu Asp Gly Met Asp Val Trp Gly
100 105 110
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 520
<211> 123
<212> PRT
<213> Homo sapiens
<400> 520
Gln Leu Gln Val Val Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Pro Val Ile Asn Thr
20 25 30
Asn Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu
35 40 45
Trp Ile Gly Thr Leu Ser Tyr Ser Gly Gly Thr His Tyr Asn Pro Ser
50 55 60
Leu Ser Ser Arg Val Thr Ile Ala Val Asp Ser Ser Lys Lys Arg Phe
65 70 75 80
Ser Leu Thr Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr
85 90 95
Cys Ala Arg His Pro Val Asp Gly Tyr Asn Tyr Gly Tyr Ser Asp Leu
100 105 110
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 521
<211> 130
<212> PRT
<213> Homo sapiens
<400> 521
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Ile Asn Pro Asn Ser Arg Gly Thr Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Val Tyr
65 70 75 80
Met Glu Leu Ser Arg Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Val Val Val Leu Gly Tyr Gly Arg Pro Asn Asn Tyr Tyr Asp
100 105 110
Gly Arg Asn Val Trp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val
115 120 125
Ser Ser
130
<210> 522
<211> 121
<212> PRT
<213> Homo sapiens
<400> 522
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Glu Ile Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Thr Thr Leu Asp
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ala Gly Gly Gly Ser Tyr Arg Gly Pro Phe Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 523
<211> 121
<212> PRT
<213> Homo sapiens
<400> 523
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Thr Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Ser Tyr Asn Gly Asn Tyr Tyr Asp Ala Phe Asp Ile Trp Gly
100 105 110
Gln Gly Thr Met Val Thr Val Ser Ser
115 120
<210> 524
<211> 121
<212> PRT
<213> Homo sapiens
<400> 524
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Ser Ala Gly Asn Tyr Tyr Tyr Gly Met Asp Val Trp Gly
100 105 110
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 525
<211> 127
<212> PRT
<213> Homo sapiens
<400> 525
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Ser Asp Tyr
20 25 30
Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
35 40 45
Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe
50 55 60
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65 70 75 80
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
85 90 95
Ala Arg Leu Thr Phe Gly Gly Ser Gly Ser Tyr Tyr Phe Tyr Tyr Asn
100 105 110
Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 526
<211> 125
<212> PRT
<213> Homo sapiens
<400> 526
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Asp Met His Trp Val Arg Gln Ala Thr Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Gly Thr Ala Gly Asp Thr Tyr Tyr Pro Gly Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Ser Leu Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Ala Gly Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Ala Asp Pro Tyr Gln Leu Leu Gly Gln His Tyr Tyr Tyr Gly Met
100 105 110
Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 527
<211> 127
<212> PRT
<213> Homo sapiens
<400> 527
Gln Val His Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr
20 25 30
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Asn Asp Glu Phe Asn Lys Phe Tyr Ala Asn Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Leu Asn Ser Leu Arg Thr Glu Asp Thr Ala Arg Tyr Tyr Cys
85 90 95
Ala Lys Gly Gly Asp Gly Ser Gly Trp Ala Trp Asp Gly Asp Asn Pro
100 105 110
Pro Thr Asp Tyr Trp Gly Gln Gly Thr Leu Val Ile Val Ser Ser
115 120 125
<210> 528
<211> 126
<212> PRT
<213> Homo sapiens
<400> 528
Gln Val Thr Leu Lys Glu Ser Gly Pro Val Leu Val Lys Pro Thr Glu
1 5 10 15
Thr Leu Thr Leu Thr Cys Ala Val Ser Gly Phe Ser Leu Ser Asn Ala
20 25 30
Lys Met Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu
35 40 45
Trp Leu Ala His Ile Phe Ser Asn Asp Glu Lys Ala Tyr Ser Thr Ser
50 55 60
Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val
65 70 75 80
Val Leu Thr Val Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr
85 90 95
Cys Ala Arg Ile Val Leu Gly Ala Ser Gly Thr Tyr Pro Ser Pro Gly
100 105 110
Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 529
<211> 121
<212> PRT
<213> Homo sapiens
<400> 529
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile Tyr
20 25 30
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Phe Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Asp Gly Ser Gly Ser Tyr Tyr Gly Trp Phe Asp Pro Trp Gly
100 105 110
Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 530
<211> 121
<212> PRT
<213> Homo sapiens
<400> 530
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr
20 25 30
Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Phe Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Val Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ser Cys Gly Asp Cys Tyr Ser Ala Asp Leu Asp Phe Trp Gly
100 105 110
Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 531
<211> 120
<212> PRT
<213> Homo sapiens
<400> 531
Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser
20 25 30
Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu
35 40 45
Trp Ile Gly Ser Met Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser
50 55 60
Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe
65 70 75 80
Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
85 90 95
Cys Ala Arg Leu Leu Trp Leu Arg Gly His Phe Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 532
<211> 129
<212> PRT
<213> Homo sapiens
<400> 532
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Asp Asp Tyr
20 25 30
Asp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Gly Ile Ser Trp Asn Gly Gly Asn Thr Gly Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr His Cys
85 90 95
Ala Val Ile Met Ser Pro Ile Pro Arg Tyr Ser Gly Tyr Asp Trp Ala
100 105 110
Gly Gly Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser
115 120 125
Ser
<210> 533
<211> 117
<212> PRT
<213> Homo sapiens
<400> 533
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Phe Tyr
20 25 30
Ala Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ala
35 40 45
Ala Ala Ile Ser Ser Asp Gly Thr Tyr Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Ser Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ala Leu Asn Lys Gly Phe Asp Pro Trp Gly Gln Gly Thr Leu
100 105 110
Leu Thr Val Ser Ser
115
<210> 534
<211> 123
<212> PRT
<213> Homo sapiens
<400> 534
Gln Met Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Thr
1 5 10 15
Ser Val Lys Val Ser Cys Lys Thr Ser Gly Phe Thr Phe Thr Ser Ser
20 25 30
Ala Ile Gln Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Ile
35 40 45
Gly Trp Ile Val Val Gly Ser Gly Asn Thr Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Glu Arg Val Thr Ile Thr Arg Asp Met Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ala Pro His Cys Asn Arg Thr Ser Cys Tyr Asp Ala Phe Asp Leu
100 105 110
Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120
<210> 535
<211> 127
<212> PRT
<213> Homo sapiens
<400> 535
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Gln Val Ser Cys Glu Ala Ser Gly Tyr Thr Phe Thr Thr Tyr
20 25 30
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Thr Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65 70 75 80
Met Asp Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Arg Leu Gly Asp Gly Ser Tyr Leu Gly Gly Gly Tyr Tyr
100 105 110
Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 536
<211> 123
<212> PRT
<213> Homo sapiens
<400> 536
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Gln Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Asp Ile Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Met Lys Ser Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Arg Asn Thr Ser Ile Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Thr Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Met Arg Ser Gly Trp Pro Thr His Gly Arg Pro Asp Asp Leu
100 105 110
Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 537
<211> 127
<212> PRT
<213> Homo sapiens
<400> 537
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr
20 25 30
Thr Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Arg Ile Ile Pro Ile Leu Ala Val Ala Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp His Ser Gly Tyr Tyr Asp Ser Thr Ser Leu Met Ser Pro
100 105 110
Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 538
<211> 124
<212> PRT
<213> Homo sapiens
<400> 538
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser His
20 25 30
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Gly Asp Thr Ser Thr Ser Thr Val Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Leu Ala Gly Val Pro Ala Ala Leu Gly Cys Trp Phe Asp
100 105 110
Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 539
<211> 127
<212> PRT
<213> Homo sapiens
<400> 539
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Gly Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Asn Leu Gly Pro Tyr Cys Ser Gly Gly Thr Cys Tyr Ser Leu
100 105 110
Val Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 540
<211> 119
<212> PRT
<213> Homo sapiens
<400> 540
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Asp Met His Trp Val Arg Gln Ala Thr Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Gly Thr Ala Gly Asp Thr Tyr Tyr Pro Gly Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Ser Leu Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Ala Gly Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Ala Arg Gly Gly Tyr Asn Trp Asn Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 541
<211> 120
<212> PRT
<213> Homo sapiens
<400> 541
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Ser Tyr Lys Tyr Phe Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Gln Gly Thr Val Val Thr His Phe Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 542
<211> 127
<212> PRT
<213> Homo sapiens
<400> 542
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr
20 25 30
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Met Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Asn Leu Gly Pro Tyr Cys Ser Gly Gly Thr Cys Tyr Ser Leu
100 105 110
Val Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 543
<211> 123
<212> PRT
<213> Homo sapiens
<400> 543
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Asp Ile Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Met Ser Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Asn Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Met Arg Ser Gly Trp Pro Thr His Gly Arg Pro Asp Asp His
100 105 110
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 544
<211> 127
<212> PRT
<213> Homo sapiens
<400> 544
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Leu Ile Ser Gly Asp Gly Gly Asn Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Lys Asp Glu Met Ala Tyr Pro Pro Ser His His Tyr Tyr Tyr Tyr
100 105 110
Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 545
<211> 123
<212> PRT
<213> Homo sapiens
<400> 545
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Thr Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Asp Ile Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Pro Glu Trp Met
35 40 45
Gly Trp Met Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala His Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Arg Asn Thr Ser Ile Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Pro Ser Ile Leu Thr Gly Phe Tyr Asn Pro Leu Asp Tyr
100 105 110
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 546
<211> 130
<212> PRT
<213> Homo sapiens
<400> 546
Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser
20 25 30
Asn Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu
35 40 45
Trp Ile Gly Thr Ile His Tyr Ser Gly Ile Ser Tyr Tyr Asn Pro Ser
50 55 60
Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Asn Asn Lys Phe
65 70 75 80
Ser Leu Glu Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Phe
85 90 95
Cys Ala Arg Arg Thr Tyr Tyr Asp Leu Trp Ser Ala Tyr Ser Ser Thr
100 105 110
Ala Tyr Tyr Cys Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val
115 120 125
Ser Ser
130
<210> 547
<211> 122
<212> PRT
<213> Homo sapiens
<400> 547
Gln Val Arg Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asp Tyr
20 25 30
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Phe Thr Ile Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Leu Ser Gly Ser Gly Trp Leu Gly Tyr Ala Met Asp Val Trp
100 105 110
Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 548
<211> 117
<212> PRT
<213> Homo sapiens
<400> 548
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Asn Asp Gly Arg Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Leu Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Pro Ser Asn Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu
100 105 110
Val Thr Val Ser Ser
115
<210> 549
<211> 127
<212> PRT
<213> Homo sapiens
<400> 549
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Gly Ile Asp Trp Asn Gly Gly Thr Ile Gly Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Lys Ala Gly Tyr Tyr Ala Tyr Val Trp Gly Ser Tyr Arg Phe Glu
100 105 110
Tyr Phe Asp Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 550
<211> 117
<212> PRT
<213> Homo sapiens
<400> 550
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Val Thr Val Ser Ser Asn
20 25 30
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Leu Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg His Asn Ser Lys Asn Thr Leu Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Gly Pro Glu Pro Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met
100 105 110
Val Thr Val Ser Ser
115
<210> 551
<211> 122
<212> PRT
<213> Homo sapiens
<400> 551
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Gly
20 25 30
Ser Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu
35 40 45
Cys Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Ser Asn Tyr Asn Pro Ser
50 55 60
Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe
65 70 75 80
Ser Leu Lys Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
85 90 95
Cys Ala Gly Ser Pro Val Pro Pro Thr Ile Val Gly Ala Ser Tyr Trp
100 105 110
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 552
<211> 127
<212> PRT
<213> Homo sapiens
<400> 552
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Asp Ile Ser Phe Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Ser Glu Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asp Ser Leu Arg Ala Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Leu Ser Thr Thr Trp Tyr Leu Glu Met Trp Gly Pro Asp
100 105 110
Ala Phe Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser
115 120 125
<210> 553
<211> 127
<212> PRT
<213> Homo sapiens
<400> 553
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Arg Tyr
20 25 30
Gly Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Thr Asp Lys Tyr Tyr Thr Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Lys Gly Gly Pro Tyr Cys Gly Gly Gly Asn Cys Tyr Ala Gly
100 105 110
Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 554
<211> 122
<212> PRT
<213> Homo sapiens
<400> 554
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Phe Ser Ala Tyr
20 25 30
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
35 40 45
Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Arg
50 55 60
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
65 70 75 80
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Val Gly Tyr Ser Gln Gly Tyr Tyr Tyr Tyr Tyr Met Asp Val Trp
100 105 110
Gly Lys Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 555
<211> 127
<212> PRT
<213> Homo sapiens
<400> 555
Glu Val Gln Val Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Val Ser Ser Gly Phe Ile Phe Asp Asp Tyr
20 25 30
Val Met His Trp Val Arg Gln Arg Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Gly Ile Thr Tyr Asn Gly Gly Ile Leu Gly Tyr Gly Asp Ser Val
50 55 60
Lys Gly Arg Phe Ile Ile Ala Arg Asp Asn Val Arg Gly Phe Leu Ser
65 70 75 80
Leu Gln Met Gly Asp Leu Arg Thr Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Arg Asp Tyr Cys Ser Ser Thr Thr Cys Pro Ala Glu Thr Tyr Tyr
100 105 110
Tyr Met Asp Val Trp Gly Lys Gly Thr Ala Val Thr Val Ser Ser
115 120 125
<210> 556
<211> 116
<212> PRT
<213> Homo sapiens
<400> 556
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Val Thr Val Ser Ser Asn
20 25 30
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Leu Ile Tyr Ser Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Asp Phe Leu Arg Trp His Asp Leu Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 557
<211> 120
<212> PRT
<213> Homo sapiens
<400> 557
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Asp Met His Trp Val Arg Gln Ala Thr Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Thr Ile Gly Thr Ala Gly Asp Thr Tyr Tyr Pro Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Ser Leu Phe Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Ala Gly Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Val Asp Phe Asp Ile Leu Thr Gly Tyr Tyr Ser Asn Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 558
<211> 122
<212> PRT
<213> Homo sapiens
<400> 558
Glu Ala Gln Leu Leu Glu Ser Gly Gly Ala Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Cys Cys
20 25 30
Ala Met Gly Trp Val Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile His Asp Asp Gly Val Gly Thr Phe Tyr Ala Val Ser Val
50 55 60
Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Gly Leu Arg Ala Glu Asp Thr Gly Val Tyr Tyr Cys
85 90 95
Ala Lys Trp Ala Gly Pro Ile Val Met Lys Tyr Tyr Leu Gln Tyr Trp
100 105 110
Gly Gln Gly Ala Leu Val Thr Val Ser Ser
115 120
<210> 559
<211> 123
<212> PRT
<213> Homo sapiens
<400> 559
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Asp Met His Trp Val Arg Gln Ala Thr Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Gly Thr Ala Gly Asp Thr Tyr Tyr Pro Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Ser Leu Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Ala Gly Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Gly Gly Asp Ser Gly Tyr Asp Leu Gly Ala Trp Tyr Phe Asp Leu
100 105 110
Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 560
<211> 119
<212> PRT
<213> Homo sapiens
<400> 560
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asn Tyr
20 25 30
Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
35 40 45
Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe
50 55 60
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65 70 75 80
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
85 90 95
Ala Arg Thr Pro Thr Leu Tyr Asn Trp Phe His Pro Trp Gly Gln Gly
100 105 110
Thr Pro Val Thr Val Ser Ser
115
<210> 561
<211> 120
<212> PRT
<213> Homo sapiens
<400> 561
Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln
1 5 10 15
Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser
20 25 30
Gly Leu Cys Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu
35 40 45
Trp Leu Ala Arg Ile Asp Trp Asp Asp Asp Lys Tyr Tyr Asn Thr Ser
50 55 60
Leu Arg Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val
65 70 75 80
Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr
85 90 95
Cys Ala Arg Ala Thr Thr Phe Phe Tyr Gly Met Asp Val Trp Gly Gln
100 105 110
Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 562
<211> 125
<212> PRT
<213> Homo sapiens
<400> 562
Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser
20 25 30
Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu
35 40 45
Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ile Thr Tyr Tyr Asn Pro Ser
50 55 60
Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe
65 70 75 80
Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
85 90 95
Cys Ala Arg His Gln Arg Tyr Cys Ser Ser Ser Ser Cys His Val Trp
100 105 110
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 563
<211> 121
<212> PRT
<213> Homo sapiens
<400> 563
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Gly Ile Ser Trp Asn Ser Asp Ser Ile Gly Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys
85 90 95
Ala Lys Gly Arg Gly Ala Gly Tyr Thr Ser Tyr Met Asp Val Trp Gly
100 105 110
Lys Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 564
<211> 122
<212> PRT
<213> Homo sapiens
<400> 564
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn
20 25 30
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Val Ile Tyr Pro Gly Gly Ser Ala Phe Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg His Asn Ser Asn Asn Thr Leu Cys Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Ser Tyr Asp Ile Leu Thr Gly Tyr Arg Asp Ala Phe Asp Ile Trp
100 105 110
Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120
<210> 565
<211> 129
<212> PRT
<213> Homo sapiens
<400> 565
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Asp Asn Ser Pro Gln Gly Ser Gly Trp Tyr Phe Tyr Tyr
100 105 110
Tyr Tyr Ala Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser
115 120 125
Ser
<210> 566
<211> 124
<212> PRT
<213> Homo sapiens
<400> 566
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Ile Gly Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Trp Ala Pro Thr Tyr Tyr Asp Met Pro Ser Ala Phe Asp
100 105 110
Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120
<210> 567
<211> 119
<212> PRT
<213> Homo sapiens
<400> 567
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Ser
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Val Arg Leu Gly Val Ser Ser Trp Tyr Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 568
<211> 133
<212> PRT
<213> Homo sapiens
<400> 568
Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser His
20 25 30
Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Asn Ile Lys Glu Asp Gly Arg Glu Lys Tyr Tyr Val Asp Ser Val
50 55 60
Lys Gly Arg Leu Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Val Val Val Glu Val Ala Thr Asn Lys Gly Ile His Gly Val
100 105 110
Asp Tyr Tyr Tyr Tyr Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr Thr
115 120 125
Val Thr Val Ser Ser
130
<210> 569
<211> 121
<212> PRT
<213> Homo sapiens
<400> 569
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Arg Thr Cys Ala Val Tyr Gly Ala Ser Phe Ser Asn Tyr
20 25 30
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
35 40 45
Gly Glu Ile Asn His Ser Glu Asn Thr Asn Tyr Asn Pro Ser Leu Lys
50 55 60
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
65 70 75 80
Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Leu Arg Tyr Ser Ser Ser Gly Gly His Ile Phe Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 570
<211> 125
<212> PRT
<213> Homo sapiens
<400> 570
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr
20 25 30
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Leu Thr Gly Ser Ser Ala Tyr Lys Asp Glu Ile Tyr Phe
100 105 110
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 571
<211> 127
<212> PRT
<213> Homo sapiens
<400> 571
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr
20 25 30
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
35 40 45
Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Lys Tyr Asn Pro Ser Leu Lys
50 55 60
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
65 70 75 80
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Asp Gly Gly Asn Ala Tyr Ser Ser Gly Trp Tyr Arg Tyr Tyr Tyr
100 105 110
His Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 572
<211> 122
<212> PRT
<213> Homo sapiens
<400> 572
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Asp Leu His Trp Val Arg Gln Gly Thr Gly Lys Arg Leu Glu Trp Val
35 40 45
Ser Ala Ile Gly Thr Ala Gly Asp Thr Tyr Tyr Leu Gly Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Ser Leu Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Ala Gly Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Val Leu Tyr Asp Ser Ser Gly Phe Tyr Asn Trp Phe Asp Pro Trp
100 105 110
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 573
<211> 123
<212> PRT
<213> Homo sapiens
<400> 573
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Arg Val Ser Cys Lys Ala Pro Gly Tyr Thr Phe Thr Thr Tyr
20 25 30
Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Ile Ile Asn Pro Ser Ala Gly Ser Thr Thr Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Phe His Val Pro Ala Ala Leu Arg Asn Trp Phe Asp Pro
100 105 110
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 574
<211> 122
<212> PRT
<213> Homo sapiens
<400> 574
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn
20 25 30
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Val Ile Tyr Pro Gly Gly Ser Ala Phe Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg His Asn Ser Asn Asn Thr Leu Cys Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Ser Tyr Asp Ile Leu Thr Gly Tyr Arg Asp Ala Phe Asp Ile Trp
100 105 110
Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120
<210> 575
<211> 124
<212> PRT
<213> Homo sapiens
<400> 575
Glu Ala Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Ile Phe Ser Ser Tyr
20 25 30
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Val Asn Asp Gly Arg Pro Asn Pro Leu Glu Tyr Tyr Phe Asp
100 105 110
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 576
<211> 124
<212> PRT
<213> Homo sapiens
<400> 576
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Gly
20 25 30
Arg Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu
35 40 45
Trp Ile Gly Phe Val Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser
50 55 60
Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe
65 70 75 80
Ser Leu Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
85 90 95
Cys Ala Arg Glu Thr Tyr Ser Ala Tyr Glu Met Pro Pro Tyr Phe Asp
100 105 110
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 577
<211> 128
<212> PRT
<213> Homo sapiens
<400> 577
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr
20 25 30
Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
35 40 45
Gly Ile Ile Gln Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe
50 55 60
Gln Gly Gln Val Thr Met Ser Ala Asp Lys Ser Thr Ser Thr Ala Tyr
65 70 75 80
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
85 90 95
Ala Arg Asp Leu Ile Ile Glu Ser Thr Ile Ala Ala Arg Pro Gly Tyr
100 105 110
Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 578
<211> 119
<212> PRT
<213> Homo sapiens
<400> 578
Gln Val His Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr
20 25 30
Leu Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Asn Val Asn Pro Ser Arg Gly Thr Ala Thr Tyr Pro Gln Lys Leu
50 55 60
Asp Asp Arg Val Thr Met Thr Ser Asp Lys Ser Ala Ser Thr Ile Tyr
65 70 75 80
Met Glu Leu Ser Gly Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys
85 90 95
Ala Arg Glu Arg Ser Gly Thr Tyr Phe Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Leu Thr Val Ser Ser
115
<210> 579
<211> 119
<212> PRT
<213> Homo sapiens
<400> 579
Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln
1 5 10 15
Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser
20 25 30
Gly Met Cys Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu
35 40 45
Trp Leu Ala Arg Ile Asp Trp Asp Asp Asp Lys Tyr Tyr Ser Thr Ser
50 55 60
Leu Gln Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val
65 70 75 80
Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr
85 90 95
Cys Ala Arg Glu Thr Pro Val Thr Ala Ile Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 580
<211> 123
<212> PRT
<213> Homo sapiens
<400> 580
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Met Ser Ser
20 25 30
Ala Val Gln Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Ile
35 40 45
Gly Trp Ile Val Ile Gly Ser Gly Asn Thr Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Glu Arg Val Thr Ile Thr Arg Asp Met Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ala Pro Tyr Cys Ser Ser Ile Ser Cys Asn Asp Gly Phe Asp Ile
100 105 110
Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120
<210> 581
<211> 123
<212> PRT
<213> Homo sapiens
<400> 581
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Phe Thr Gly Tyr
20 25 30
Val Val His Trp Val Arg Gln Ala Pro Gly Gln Asp Leu Glu Trp Met
35 40 45
Gly Trp Ile Asn Thr Gly Tyr Gly Asn Thr Lys Tyr Ser Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Ile Ser Trp Asp Thr Ser Ala Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Asn Leu Lys Ser Glu Asp Lys Ala Val Tyr Tyr Cys
85 90 95
Ala Ser Met Thr Arg Met Ser Glu Gln Thr Tyr Tyr Gly Met Asp Val
100 105 110
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 582
<211> 115
<212> PRT
<213> Homo sapiens
<400> 582
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ala Tyr Tyr Cys
85 90 95
Ala Arg Glu Leu Met Ser Val Gly Trp Gly Gln Gly Thr Leu Val Thr
100 105 110
Val Ser Ser
115
<210> 583
<211> 123
<212> PRT
<213> Homo sapiens
<400> 583
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Val Ser Ser Asn
20 25 30
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Val Ile Tyr Ala Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Asp Ala Leu Tyr Tyr Asn Gly Pro Gly Arg Asp Gly Met Asp Val
100 105 110
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 584
<211> 123
<212> PRT
<213> Homo sapiens
<400> 584
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Val Ser Ser Asn
20 25 30
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Val Ile Tyr Ala Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Asp Ala Leu Tyr Tyr Asn Gly Pro Gly Arg Asp Gly Met Asp Val
100 105 110
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 585
<211> 126
<212> PRT
<213> Homo sapiens
<400> 585
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Ser Asp Gly Ser Asn Lys Tyr Tyr Ala Gly Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Asp Met Val Glu Pro Leu Phe Ser His Tyr Tyr Tyr Tyr Gly
100 105 110
Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 586
<211> 123
<212> PRT
<213> Homo sapiens
<400> 586
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr
20 25 30
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
35 40 45
Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys
50 55 60
Ser Arg Val Thr Ile Ser Val Asp Met Ser Lys Asn Gln Phe Ser Leu
65 70 75 80
Lys Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Ala Pro Arg Glu Arg Leu Gln Trp Gly Glu Tyr Tyr Phe Asp Tyr
100 105 110
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 587
<211> 128
<212> PRT
<213> Homo sapiens
<400> 587
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Tyr
20 25 30
Asp Met His Trp Val Arg Gln Val Thr Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Thr Ile Gly Thr Ala Gly Asp Thr Tyr Tyr Pro Gly Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Ser Leu Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Ala Gly Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Val Phe Glu Thr Lys Val Ile Arg Gly Gly Arg Tyr Tyr Tyr Tyr
100 105 110
Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 588
<211> 122
<212> PRT
<213> Homo sapiens
<400> 588
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr
20 25 30
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
35 40 45
Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys
50 55 60
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn His Phe Ser Leu
65 70 75 80
Lys Met Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Cys Arg Gln Met Gly Asn Phe Tyr Tyr Tyr Tyr Met Asp Val Trp
100 105 110
Gly Lys Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 589
<211> 123
<212> PRT
<213> Homo sapiens
<400> 589
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ala
20 25 30
Gly Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu
35 40 45
Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Arg Thr Tyr Tyr Asn Pro Ser
50 55 60
Leu Lys Ser Arg Val Thr Met Ser Val Asp Thr Ser Lys Asn Gln Phe
65 70 75 80
Ser Leu Arg Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
85 90 95
Cys Ala Arg Val Val Pro Thr Arg Gly Pro Val Ala Trp Phe Asp Pro
100 105 110
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 590
<211> 128
<212> PRT
<213> Homo sapiens
<400> 590
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Trp Tyr Asp Gly Ser Lys Lys Asp Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Gln Ser Gln Gly Ala Tyr Ile Leu Thr Gly Tyr Arg Gly
100 105 110
Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 591
<211> 124
<212> PRT
<213> Homo sapiens
<400> 591
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Thr Ala Gly Gly Thr Ser Ser Ser Tyr
20 25 30
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Arg Ile Ile Pro Ile Leu Gly Val Ala Ile Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Asn Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Thr Thr Thr Gln Gly Gly Asp Tyr Gly Asp Asn Leu Tyr Tyr Leu Asp
100 105 110
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 592
<211> 117
<212> PRT
<213> Homo sapiens
<400> 592
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Val Thr Val Ser Ser Asn
20 25 30
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Leu Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg His Asn Ser Lys Asn Thr Leu Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Gly Pro Glu Pro Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met
100 105 110
Val Thr Val Ser Ser
115
<210> 593
<211> 123
<212> PRT
<213> Homo sapiens
<400> 593
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Asp Thr Phe Thr Thr Tyr
20 25 30
Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Ile Ile Asn Pro Ser Gly Gly Ser Arg Ser Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Ile Ser Met Thr Ser Asp Thr Ser Thr Ser Thr Val Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Tyr Gly Phe Val Pro Asn Val Leu Tyr Tyr Phe Asp Tyr
100 105 110
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Thr
115 120
<210> 594
<211> 120
<212> PRT
<213> Homo sapiens
<400> 594
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Ser Ser Gly Gly Ser Tyr Ile Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Gly Ser Ile Leu Trp Trp Leu Ile Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 595
<211> 123
<212> PRT
<213> Homo sapiens
<400> 595
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Ser Tyr
20 25 30
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Gly Ile Ser Ile Ser Gly Gly Ser Thr Tyr Tyr Ala Ala Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Asp Ser Arg Ser Gly Ile Ala Gly Val Asp Ala Phe Asp Ile
100 105 110
Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120
<210> 596
<211> 119
<212> PRT
<213> Homo sapiens
<400> 596
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Val Ser Ser Asn
20 25 30
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Cys Val
35 40 45
Ser Val Ile Tyr Ala Gly Gly Asn Thr Tyr Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Gly Asp Gly Gly Tyr Tyr Ser Pro Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 597
<211> 127
<212> PRT
<213> Homo sapiens
<400> 597
Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln
1 5 10 15
Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser
20 25 30
Gly Val Gly Val Ala Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu
35 40 45
Trp Leu Ala Leu Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Ser Pro Ser
50 55 60
Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val
65 70 75 80
Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr
85 90 95
Cys Ala His Arg Leu Pro Thr Pro Gln Leu Leu Pro Ser Phe Glu Asn
100 105 110
Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 598
<211> 116
<212> PRT
<213> Homo sapiens
<400> 598
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Val Gly Ser Asn
20 25 30
Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
65 70 75 80
Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Glu Val Val Gly Tyr Phe Asp Cys Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 599
<211> 118
<212> PRT
<213> Homo sapiens
<400> 599
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr
20 25 30
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
35 40 45
Gly His Ile Tyr Tyr Thr Gly Ser Ser Tyr Tyr Asn Pro Ser Leu Lys
50 55 60
Ser Arg Val Thr Ile Ser Leu Asp Thr Ser Lys Asn Gln Phe Ser Leu
65 70 75 80
Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Leu Arg Trp Leu Arg Gly Gly Ile Asp Phe Trp Gly Gln Gly Thr
100 105 110
Leu Val Ile Val Ser Ser
115
<210> 600
<211> 123
<212> PRT
<213> Homo sapiens
<400> 600
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Asp Thr Phe Thr Thr Tyr
20 25 30
Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Ile Ile Asn Pro Ser Gly Gly Ser Arg Ser Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Ile Ser Met Thr Ser Asp Thr Ser Thr Ser Thr Val Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Tyr Gly Phe Val Pro Asn Val Leu Tyr Tyr Phe Asp Tyr
100 105 110
Trp Gly Gln Gly Ile Leu Val Thr Val Ser Ser
115 120
<210> 601
<211> 121
<212> PRT
<213> Homo sapiens
<400> 601
Gln Val Glu Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Ser Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Gly Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ala Gln Gly Gly Asn Tyr Tyr Tyr Gly Met Asp Val Trp Gly
100 105 110
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 602
<211> 132
<212> PRT
<213> Homo sapiens
<400> 602
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr
20 25 30
Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Leu Ile Ser Tyr Asp Gly Arg Asn Glu Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Gly Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Leu Ala Tyr His Pro Tyr Arg Asp Tyr Gly Asp Asp Asp
100 105 110
Tyr Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val
115 120 125
Thr Val Ser Ser
130
<210> 603
<211> 122
<212> PRT
<213> Homo sapiens
<400> 603
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Ile Ile Asn Pro Gly Gly Gly Ser Thr Thr Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Ser Asp Thr Ser Thr Ser Thr Val Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys
85 90 95
Ala Arg Gly Ala Ile Pro Pro Asn Ser Arg Ala Glu Ile Asp Tyr Trp
100 105 110
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 604
<211> 128
<212> PRT
<213> Homo sapiens
<400> 604
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Tyr Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Thr Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Ala Val Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu Asn Asp Tyr Gly Asp Tyr Val Glu Pro Arg Asp Tyr Tyr
100 105 110
Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 605
<211> 124
<212> PRT
<213> Homo sapiens
<400> 605
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr
20 25 30
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Trp Tyr Asp Gly Asn Lys Lys Tyr Cys Ala Asp Ser Val
50 55 60
Lys Gly Arg Cys Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu Gly Pro Phe Gly Asp Arg Glu Ala Ser Gly Ala Phe Asp
100 105 110
Val Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120
<210> 606
<211> 120
<212> PRT
<213> Homo sapiens
<400> 606
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr
20 25 30
Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Tyr Ile Ser Ser Ser Gly Ile Thr Ile Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Thr Gly Val Val Ala Ala Pro Ala Glu Tyr Phe Gln His Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 607
<211> 119
<212> PRT
<213> Homo sapiens
<400> 607
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg His
20 25 30
Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val
50 55 60
Lys Gly Arg Leu Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Leu Gly Phe Tyr Tyr Gly Gly Ala Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 608
<211> 118
<212> PRT
<213> Homo sapiens
<400> 608
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr
20 25 30
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys
85 90 95
Ala Lys Asp Gly Ser Ile Ala Ala Ala Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Leu Val Thr Val Ser Ser
115
<210> 609
<211> 121
<212> PRT
<213> Homo sapiens
<400> 609
Gln Val Gln Leu Val Gln Ala Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Ala Ala Val Pro Ala Ala Gly Glu Phe Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 610
<211> 121
<212> PRT
<213> Homo sapiens
<400> 610
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Ser Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr
20 25 30
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Ile Ile Ser Tyr Asp Gly Ile Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Met Tyr Tyr Cys
85 90 95
Ala Lys Gly Asp Gly Ser Tyr Leu Met Asp Tyr Phe Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 611
<211> 122
<212> PRT
<213> Homo sapiens
<400> 611
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn
20 25 30
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Val Ile Tyr Pro Gly Gly Ser Ala Phe Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg His Asn Ser Asn Asn Thr Leu Cys Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Ser Tyr Asp Ile Leu Thr Gly Tyr Arg Asp Ala Phe Asp Ile Trp
100 105 110
Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120
<210> 612
<211> 122
<212> PRT
<213> Homo sapiens
<400> 612
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr
20 25 30
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
35 40 45
Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys
50 55 60
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn His Phe Ser Leu
65 70 75 80
Lys Met Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Cys Arg Gln Met Gly Asn Phe Tyr Tyr Tyr Tyr Met Asp Val Trp
100 105 110
Gly Lys Gly Thr Thr Val Thr Val Ser Pro
115 120
<210> 613
<211> 125
<212> PRT
<213> Homo sapiens
<400> 613
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr
20 25 30
Trp Val Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
35 40 45
Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Asp Ser Pro Ser Phe
50 55 60
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65 70 75 80
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
85 90 95
Ala Arg Leu Gly Ser Glu Ser Lys Ile Asp Tyr Tyr Tyr Tyr Gly Met
100 105 110
Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 614
<211> 124
<212> PRT
<213> Homo sapiens
<400> 614
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Asp Thr Phe Ser Ser Tyr
20 25 30
Thr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Arg Ile Ile Pro Ile Leu Gly Ile Pro Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Phe
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Arg Gly Tyr Ser Asn Tyr Gly Ala Ser Tyr Tyr Met Asp
100 105 110
Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 615
<211> 123
<212> PRT
<213> Homo sapiens
<400> 615
Gln Leu Gln Leu Arg Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser
20 25 30
Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu
35 40 45
Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser
50 55 60
Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe
65 70 75 80
Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Phe Tyr
85 90 95
Cys Ala Arg Met Ser Arg Gly Tyr Asn Tyr Ala Tyr Thr Phe Asp Ile
100 105 110
Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120
<210> 616
<211> 120
<212> PRT
<213> Homo sapiens
<400> 616
Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln
1 5 10 15
Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser
20 25 30
Gly Met Cys Leu Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu
35 40 45
Trp Leu Ala Arg Ile Asp Trp Asp Asp Asp Lys Tyr Tyr Ser Thr Ser
50 55 60
Leu Glu Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val
65 70 75 80
Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Gly Thr Tyr Tyr
85 90 95
Cys Ala Arg Thr Met Ala Thr Ile Asn Ala Phe Asp Ile Trp Gly Gln
100 105 110
Gly Thr Met Val Thr Val Ser Ser
115 120
<210> 617
<211> 119
<212> PRT
<213> Homo sapiens
<400> 617
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Tyr Tyr
20 25 30
Pro Met His Trp Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu
35 40 45
Trp Val Ala Val Thr Ser Tyr Asp Gly Thr Asn Lys Tyr Tyr Ala Asp
50 55 60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr
65 70 75 80
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
85 90 95
Tyr Cys Ala Arg Gly Gly Ala Thr Asn Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 618
<211> 118
<212> PRT
<213> Homo sapiens
<400> 618
Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Glu Tyr Thr Phe Thr Ser Tyr
20 25 30
Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Ile Asn Thr Asn Thr Gly Asn Pro Thr Tyr Ala Gln Gly Phe
50 55 60
Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr
65 70 75 80
Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Pro Gly Lys Ala Ala Ala Phe Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Leu Val Thr Val Ser Ser
115
<210> 619
<211> 128
<212> PRT
<213> Homo sapiens
<400> 619
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Glu Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Leu His Gln Asp Trp Val Val Val Val Ala Ala Asn Val
100 105 110
Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 620
<211> 123
<212> PRT
<213> Homo sapiens
<400> 620
Gln Met Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Thr
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Met Ser Ser
20 25 30
Ala Val Gln Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Ile
35 40 45
Gly Trp Ile Val Ile Gly Ser Gly Asn Thr Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Glu Arg Val Thr Ile Thr Arg Asp Met Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ala Pro Tyr Cys Ser Ser Ile Ser Cys Asn Asp Gly Phe Asp Ile
100 105 110
Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120
<210> 621
<211> 120
<212> PRT
<213> Homo sapiens
<400> 621
Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln
1 5 10 15
Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser
20 25 30
Gly Leu Cys Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu
35 40 45
Trp Leu Ala Arg Ile Asp Trp Asp Asp Asp Lys Tyr Tyr Asn Thr Ser
50 55 60
Leu Arg Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val
65 70 75 80
Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr
85 90 95
Cys Ala Arg Ala Thr Thr Phe Phe Tyr Gly Met Asp Val Trp Gly Gln
100 105 110
Gly Thr Thr Ala Thr Val Ser Ser
115 120
<210> 622
<211> 127
<212> PRT
<213> Homo sapiens
<400> 622
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Arg Tyr
20 25 30
Gly Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Thr Asp Lys Tyr Tyr Thr Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Lys Gly Gly Pro Tyr Cys Gly Gly Gly Asn Cys Tyr Ala Gly
100 105 110
Tyr Phe Asp Tyr Trp Gly Gln Gly Ile Leu Val Thr Val Ser Ser
115 120 125
<210> 623
<211> 127
<212> PRT
<213> Homo sapiens
<400> 623
Glu Val Gln Val Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Asp Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Gly Val Ser Trp Asn Ser Gly Ile Ile Gly Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Lys Leu Asp Val Gly Gly Tyr Asp Phe Val Ser Gly His Tyr Tyr
100 105 110
Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120 125
<210> 624
<211> 128
<212> PRT
<213> Homo sapiens
<400> 624
Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asp Tyr
20 25 30
Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Ile Asn Thr Asn Thr Gly Asn Pro Thr Tyr Ala Gln Gly Phe
50 55 60
Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr
65 70 75 80
Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Leu Ile Ser Leu Phe Arg Gly Ala Ile Phe His Tyr Tyr
100 105 110
Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 625
<211> 117
<212> PRT
<213> Homo sapiens
<400> 625
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Val Arg Ser Asn
20 25 30
Tyr Met Thr Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Asp Leu Val Thr Tyr Gly Leu Asp Val Trp Gly Gln Gly Thr Thr
100 105 110
Val Thr Val Ser Ser
115
<210> 626
<211> 127
<212> PRT
<213> Homo sapiens
<400> 626
Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln
1 5 10 15
Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Lys
20 25 30
Arg Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu
35 40 45
Trp Leu Ala Leu Ile Tyr Trp Asp Asp Asp Gln Arg Tyr Ser Pro Ser
50 55 60
Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val
65 70 75 80
Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr
85 90 95
Cys Ala His Ser Gly Pro Pro Asp Leu Ser Pro Val Leu Ser Gln Gly
100 105 110
Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 627
<211> 129
<212> PRT
<213> Homo sapiens
<400> 627
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Val Thr Ser
20 25 30
Gly Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Gly Pro Asn Lys Glu Val Leu Tyr Phe Gly Glu Leu Leu
100 105 110
Asp Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser
115 120 125
Ser
<210> 628
<211> 117
<212> PRT
<213> Homo sapiens
<400> 628
Gln Val Gln Val Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Lys Asn Tyr
20 25 30
Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Ile Ser Ala Tyr Thr Gly Asn Thr Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Met Thr Met Thr Thr Asp Thr Ser Thr Gly Thr Gly Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Val Gln Arg Arg Arg Leu Asp Tyr Trp Gly Gln Gly Thr Leu
100 105 110
Val Ile Val Ser Ser
115
<210> 629
<211> 123
<212> PRT
<213> Homo sapiens
<400> 629
Gln Met Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Thr
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Met Ser Ser
20 25 30
Ala Val Gln Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Ile
35 40 45
Gly Trp Ile Val Ile Gly Ser Gly Asn Thr Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Glu Arg Val Thr Ile Thr Arg Asp Met Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ala Pro Tyr Cys Ser Ser Ile Ser Cys Asn Asp Gly Phe Asp Ile
100 105 110
Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120
<210> 630
<211> 122
<212> PRT
<213> Homo sapiens
<400> 630
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Ile Ile Asn Pro Gly Gly Gly Ser Thr Thr Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Ser Asp Thr Ser Thr Ser Thr Val Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys
85 90 95
Ala Arg Gly Ala Ile Pro Pro Asn Ser Arg Ala Glu Ile Asp Tyr Trp
100 105 110
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 631
<211> 127
<212> PRT
<213> Homo sapiens
<400> 631
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Asp Ile Ser Phe Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Ser Glu Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asp Ser Leu Arg Ala Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Leu Ser Thr Thr Trp Tyr Leu Glu Met Trp Gly Pro Asp
100 105 110
Ala Phe Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser
115 120 125
<210> 632
<211> 122
<212> PRT
<213> Homo sapiens
<400> 632
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Asp Leu His Trp Val Arg Gln Gly Thr Gly Lys Arg Leu Glu Trp Val
35 40 45
Ser Ala Ile Gly Thr Ala Gly Asp Thr Tyr Tyr Leu Gly Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Ser Leu Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Ala Gly Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Val Leu Tyr Asp Ser Ser Gly Phe Tyr Asn Trp Phe Asp Pro Trp
100 105 110
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 633
<211> 127
<212> PRT
<213> Homo sapiens
<400> 633
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr
20 25 30
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Met Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Asn Leu Gly Pro Tyr Cys Ser Gly Gly Thr Cys Tyr Ser Leu
100 105 110
Val Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 634
<211> 123
<212> PRT
<213> Homo sapiens
<400> 634
Glu Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Thr
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Met Ser Ser
20 25 30
Ala Val Gln Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Ile
35 40 45
Gly Trp Ile Val Ile Gly Ser Gly Asn Thr Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Glu Arg Val Thr Ile Thr Arg Asp Met Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ala Pro Tyr Cys Ser Ser Ile Ser Cys Asn Asp Gly Phe Asp Ile
100 105 110
Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120
<210> 635
<211> 127
<212> PRT
<213> Homo sapiens
<400> 635
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Leu Ile Ser Gly Asp Gly Gly Asn Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Lys Asp Glu Met Ala Tyr Pro Pro Ser His His Tyr Tyr Tyr Tyr
100 105 110
Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 636
<211> 130
<212> PRT
<213> Homo sapiens
<400> 636
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Phe Val Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Ala Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Leu Val Thr Thr Val Thr Thr Ala Asn Gly Leu Tyr Tyr Tyr
100 105 110
Ser Tyr Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val
115 120 125
Ser Ser
130
<210> 637
<211> 121
<212> PRT
<213> Homo sapiens
<400> 637
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ala Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr
20 25 30
Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Ser Asn Arg Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Arg Ser Gly Asn Tyr Arg Asp Ala Phe Asp Ile Trp Gly
100 105 110
Gln Gly Thr Met Val Thr Val Ser Ser
115 120
<210> 638
<211> 122
<212> PRT
<213> Homo sapiens
<400> 638
His Gln His Gln Val Glu Gln Gly Pro Gly Gly Val Glu Gln Ser Glu
1 5 10 15
Thr Leu Phe Leu Thr Cys Cys Val Ser Gly Gly Phe Thr Ile Ser Ser
20 25 30
Cys Tyr Lys Arg Gly Gly Ile Arg Gln Pro Pro Arg Lys Gly Glu Glu
35 40 45
Trp Ala Val Ser Ser Tyr Tyr Ser Ser Ser Thr Tyr Tyr Thr Pro Ser
50 55 60
Leu Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe
65 70 75 80
Ser Leu Lys Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
85 90 95
Cys Ala Arg Val Ser Ser Gly Tyr Tyr Phe Thr Pro Phe Asp Tyr Trp
100 105 110
Gly Gln Gly Thr Arg Gly His Arg Leu Phe
115 120
<210> 639
<211> 121
<212> PRT
<213> Homo sapiens
<400> 639
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Ser Asn Gln Tyr Tyr Ala Asp Ser Val
50 55 60
Arg Gly Arg Phe Thr Ile Ser Arg Gly Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ala Arg Gly Gly Ser Tyr Asn Asp Ala Phe Asp Ile Trp Gly
100 105 110
Gln Gly Thr Met Val Thr Val Ser Ser
115 120
<210> 640
<211> 135
<212> PRT
<213> Homo sapiens
<400> 640
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Asp Gly Gln Tyr Tyr Asp Phe Trp Ser Gly Tyr Leu Gly Ala
100 105 110
Arg Thr Asn Pro His Tyr Tyr Tyr Tyr Met Asp Val Trp Gly Lys Gly
115 120 125
Thr Met Val Thr Val Ser Ser
130 135
<210> 641
<211> 124
<212> PRT
<213> Homo sapiens
<400> 641
Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Glu Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Asp Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Lys Asp Met Gly Glu Ala Val Ala Gly Thr His Tyr Gly Met Asp
100 105 110
Val Trp Gly Gln Gly Thr Met Val Thr Ala Ser Ser
115 120
<210> 642
<211> 122
<212> PRT
<213> Homo sapiens
<400> 642
Gln Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Leu Ser Ser Tyr
20 25 30
Ala Ile Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val
35 40 45
Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Val Gly Ala Tyr Asp Ser Ser Gly Tyr Ser Asn Asp Tyr Trp
100 105 110
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 643
<211> 121
<212> PRT
<213> Homo sapiens
<400> 643
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu Asp Tyr Tyr Asp Ser Ser Gly Ser Phe Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 644
<211> 122
<212> PRT
<213> Homo sapiens
<400> 644
Gln Leu Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr
20 25 30
Phe Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
35 40 45
Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys
50 55 60
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
65 70 75 80
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg His Ser Gln Gly Trp Leu Gln Gln Ala Val Ala Phe Asp Ile Trp
100 105 110
Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120
<210> 645
<211> 127
<212> PRT
<213> Homo sapiens
<400> 645
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Thr Ser Thr
20 25 30
Tyr Met Thr Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ile Ile Tyr Asn Asp Asp Thr Thr Tyr Tyr Ala Asp Ser Val Lys
50 55 60
Asp Arg Val Thr Val Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys Ala
85 90 95
Arg Gly Gly Tyr Tyr Tyr Asp Pro Ser Gly Tyr Tyr Ser Arg Ser Phe
100 105 110
Ser Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 646
<211> 119
<212> PRT
<213> Homo sapiens
<400> 646
Glu Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Pro Gly Tyr
20 25 30
Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Ile Asn Pro Asn Ser Gly Val Ala Lys Ser Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Arg Asp Ser Ser Ile Ser Thr Val Tyr
65 70 75 80
Leu Asp Val Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp
85 90 95
Leu Val Trp Ala Thr Val Ser Gly Thr Met Asp Val Trp Gly Gln Gly
100 105 110
Thr Thr Val Thr Val Ser Ser
115
<210> 647
<211> 129
<212> PRT
<213> Homo sapiens
<400> 647
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Ile Ile Asn Ser Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Pro Pro Arg Asn Tyr Tyr Asp Arg Ser Gly Tyr Tyr Gln Arg
100 105 110
Ala Glu Tyr Phe Gln His Trp Gly Gln Gly Thr Leu Val Thr Val Ser
115 120 125
Ser
<210> 648
<211> 118
<212> PRT
<213> Homo sapiens
<400> 648
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn
20 25 30
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Val Glu Trp Ala Ala Ala Gly Thr Phe Tyr Trp Gly Gln Gly Thr
100 105 110
Leu Val Thr Val Ser Ser
115
<210> 649
<211> 127
<212> PRT
<213> Homo sapiens
<400> 649
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Ser Ser Ser Ser Ser Phe Ile Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Trp Lys Ser Asp Tyr Tyr Asp Ser Ser Gly Tyr Tyr Pro Ala
100 105 110
Ala Phe Asp Ile Trp Gly Gln Arg Asp Lys Trp Ser Pro Ser Ser
115 120 125
<210> 650
<211> 129
<212> PRT
<213> Homo sapiens
<400> 650
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Ser Leu Phe
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Gly Asp Gln Asn Leu Tyr Cys Ser Gly Asp Ser Cys Tyr Tyr His
100 105 110
Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Val Val Thr Val Ser
115 120 125
Ser
<210> 651
<211> 133
<212> PRT
<213> Homo sapiens
<400> 651
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Ser Glu Tyr Tyr Asp Ile Leu Thr Gly Tyr Leu Ala Pro
100 105 110
Thr His Tyr Tyr Tyr Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr Thr
115 120 125
Val Thr Val Ser Ser
130
<210> 652
<211> 127
<212> PRT
<213> Homo sapiens
<400> 652
Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Ile Ser Ala Tyr Asn Gly Tyr Thr Asn Ser Ala Gln Lys Leu
50 55 60
Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Leu Val Asp Thr Ala Met Val Gln Thr Leu Asp Asp Tyr
100 105 110
Gly Met Asp Val Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120 125
<210> 653
<211> 122
<212> PRT
<213> Homo sapiens
<400> 653
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Arg Phe Thr Thr Tyr
20 25 30
Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
35 40 45
Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe
50 55 60
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65 70 75 80
Leu Gln Trp Ser Ser Leu Thr Ala Ser Asp Thr Ala Ile Tyr Tyr Cys
85 90 95
Ala Arg Tyr Tyr Tyr Asp Ser Arg Gly Tyr Thr Ser Ile Asp Phe Trp
100 105 110
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 654
<211> 129
<212> PRT
<213> Homo sapiens
<400> 654
Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Thr
20 25 30
Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu
35 40 45
Cys Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser
50 55 60
Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe
65 70 75 80
Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
85 90 95
Cys Ala Arg Leu Asn Tyr Asp Phe Trp Ser Gly Tyr Tyr Ser Tyr Ala
100 105 110
Leu Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr Met Val Thr Val Ser
115 120 125
Ser
<210> 655
<211> 124
<212> PRT
<213> Homo sapiens
<400> 655
Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly
20 25 30
Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Leu Pro Gly Lys Gly Leu Glu
35 40 45
Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser
50 55 60
Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe
65 70 75 80
Ser Leu Asn Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
85 90 95
Cys Ala Arg Gln Gln Leu Asp Tyr Tyr Asp Ser Ser Gly Cys Phe Asp
100 105 110
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 656
<211> 112
<212> PRT
<213> Homo sapiens
<400> 656
Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr
20 25 30
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Arg Leu Glu Trp Ile
35 40 45
Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys
50 55 60
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
65 70 75 80
Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Ala Tyr Tyr Cys Ala
85 90 95
Arg Gly Phe Asp Tyr Trp Gly Gln Gly Thr Arg Val Thr Val Ser Ser
100 105 110
<210> 657
<211> 120
<212> PRT
<213> Homo sapiens
<400> 657
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Asp Met His Trp Val Arg Gln Thr Thr Gly Lys Gly Leu Gln Trp Val
35 40 45
Ser Ala Ile Gly Thr Ala Gly Asp Thr Tyr Tyr Pro Gly Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Ser Leu Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Ala Gly Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Gly Gly Asp Arg Tyr Pro Val Gly Tyr Phe Asp Leu Trp Gly Arg
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 658
<211> 123
<212> PRT
<213> Homo sapiens
<400> 658
Val Gln Leu Gln Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser
20 25 30
Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu
35 40 45
Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser
50 55 60
Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe
65 70 75 80
Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
85 90 95
Cys Ala Arg Arg Ser Thr Ser Arg Trp Gly Tyr Tyr Tyr Met Asp Val
100 105 110
Trp Gly Lys Gly Thr Arg Val Thr Val Ser Ser
115 120
<210> 659
<211> 125
<212> PRT
<213> Homo sapiens
<400> 659
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu Ala Asn Ser Asp Phe Trp Ser Gly Tyr Leu Gly Tyr Phe
100 105 110
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 660
<211> 118
<212> PRT
<213> Homo sapiens
<400> 660
Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn
20 25 30
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Asp Leu Glu Arg Ala Gly Gly Met Asp Val Trp Gly Gln Gly Thr
100 105 110
Met Val Thr Val Ser Ser
115
<210> 661
<211> 127
<212> PRT
<213> Homo sapiens
<400> 661
Glu Val Gln Leu Leu Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr
20 25 30
Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
35 40 45
Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe
50 55 60
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65 70 75 80
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
85 90 95
Ala Arg His Met Arg Pro Ser Ile Ala Ala Arg Pro Gly Tyr Gln Tyr
100 105 110
Tyr Met Asp Val Trp Gly Lys Gly Thr Arg Val Thr Val Ser Ser
115 120 125
<210> 662
<211> 115
<212> PRT
<213> Homo sapiens
<400> 662
Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Val Ser Ser Asn
20 25 30
Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Glu Ala Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Met Val Thr
100 105 110
Val Ser Ser
115
<210> 663
<211> 125
<212> PRT
<213> Homo sapiens
<400> 663
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Gly Ser Gly Ser Asn Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Leu Arg Gly Gln Gln Leu Val Ile Pro Thr Glu Tyr Phe
100 105 110
Gln His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 664
<211> 126
<212> PRT
<213> Homo sapiens
<400> 664
Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Leu Ser Ser Tyr
20 25 30
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Ile Thr Thr Asp Glu Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Pro Arg Gly Cys Ser Ser Thr Ser Cys Tyr Gly Ser Tyr
100 105 110
Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 665
<211> 127
<212> PRT
<213> Homo sapiens
<400> 665
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Ser Tyr
20 25 30
Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Ser Arg Ser Ser Ser Tyr Ile Tyr Asn Ala Asp Ser Val
50 55 60
Arg Gly Arg Leu Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Gln Pro Leu Pro Asp Ile Leu Thr Gly Tyr Tyr Thr Gly
100 105 110
Pro Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 666
<211> 118
<212> PRT
<213> Homo sapiens
<400> 666
Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn
20 25 30
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Asp Leu Asp Thr Met Gly Gly Met Asp Val Trp Gly Gln Gly Thr
100 105 110
Arg Val Thr Val Ser Ser
115
<210> 667
<211> 122
<212> PRT
<213> Homo sapiens
<400> 667
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr
20 25 30
Ala Ile Ile Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Ile Thr Thr Asp Glu Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Val Arg Tyr Tyr Asp Ser Ser Gly Tyr Tyr Glu Asp Tyr Trp
100 105 110
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 668
<211> 129
<212> PRT
<213> Homo sapiens
<400> 668
Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ala
35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Asp Thr Gly Tyr Cys Gly Asp Asp Cys Tyr Ile Lys Leu Ile
100 105 110
Arg Gly Gly Pro Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
115 120 125
Ser
<210> 669
<211> 123
<212> PRT
<213> Homo sapiens
<400> 669
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Thr Val Lys Ile Ser Cys Lys Val Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Tyr Met His Trp Val Gln Gln Ala Pro Gly Lys Gly Leu Glu Trp Met
35 40 45
Gly Leu Val Asp Pro Glu Asp Gly Glu Thr Ile Tyr Ala Glu Lys Phe
50 55 60
Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Asp Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ser Ser Asp Ser Ser Gly Phe Val Gly Ser Arg Gly Phe Asp Tyr
100 105 110
Trp Gly Gln Gly Thr Arg Val Thr Val Ser Ser
115 120
<210> 670
<211> 120
<212> PRT
<213> Homo sapiens
<400> 670
Gln Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr
20 25 30
Gly Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Ile Thr Thr Asp Glu Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ser Phe Gly Asp Asp Ser Gly Asp Glu Gly Val Arg Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 671
<211> 122
<212> PRT
<213> Homo sapiens
<400> 671
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr
20 25 30
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile Ile Pro Ile Phe Gly Thr Thr Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Ile Thr Thr Asp Glu Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Val Tyr Ser Tyr Asp Ser Ser Gly Tyr Tyr Leu Glu Tyr Trp
100 105 110
Gly Gln Gly Thr Arg Val Thr Val Ser Ser
115 120
<210> 672
<211> 123
<212> PRT
<213> Homo sapiens
<400> 672
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn
20 25 30
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Ser Pro Leu Leu Leu Thr Pro Pro Asp Tyr Tyr Tyr Tyr Met Asp Val
100 105 110
Trp Gly Lys Gly Thr Met Val Thr Val Ser Ser
115 120
<210> 673
<211> 117
<212> PRT
<213> Homo sapiens
<400> 673
Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr
20 25 30
Tyr Trp Ser Trp Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu Trp Ile
35 40 45
Gly Arg Ile Tyr Thr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys
50 55 60
Ser Arg Val Thr Met Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
65 70 75 80
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Trp Lys Tyr Asn Asp Arg Phe Asp Tyr Trp Gly Gln Gly Thr Arg
100 105 110
Val Thr Val Ser Ser
115
<210> 674
<211> 127
<212> PRT
<213> Homo sapiens
<400> 674
Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr
20 25 30
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Ile Thr Thr Asp Glu Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Pro Arg Tyr Cys Ser Ser Thr Ser Cys Tyr Ala Gly Val
100 105 110
Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Arg Val Thr Val Ser Ser
115 120 125
<210> 675
<211> 127
<212> PRT
<213> Homo sapiens
<400> 675
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr
20 25 30
Trp Ile Ser Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
35 40 45
Gly Arg Ile Asp Pro Ser Asp Ser Tyr Thr Asn Tyr Ser Pro Ser Phe
50 55 60
Gln Gly His Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65 70 75 80
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
85 90 95
Ala Arg Pro Asn Pro Ala Gly Gly Tyr Asp Ser Ser Gly Trp Val Asp
100 105 110
Ala Phe Asp Ile Trp Gly Gln Gly Thr Arg Val Thr Val Ser Ser
115 120 125
<210> 676
<211> 123
<212> PRT
<213> Homo sapiens
<400> 676
Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Pro Glu Leu
20 25 30
Ser Met His Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Met
35 40 45
Gly Gly Phe Asp Pro Glu Asp Gly Glu Thr Ile Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Thr Gly Pro Thr Ile Ala Ala Ala Ala Thr Asn Trp Phe Asp Pro
100 105 110
Gly Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 677
<211> 125
<212> PRT
<213> Homo sapiens
<400> 677
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala
20 25 30
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala
50 55 60
Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr
65 70 75 80
Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
85 90 95
Tyr Cys Thr Thr Asp Arg Gly Asp Ser Tyr Gly Tyr Tyr Tyr Cys Met
100 105 110
Asp Val Trp Gly Lys Gly Thr Arg Val Thr Val Ser Ser
115 120 125
<210> 678
<211> 124
<212> PRT
<213> Homo sapiens
<400> 678
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys
85 90 95
Ala Lys Asp Lys Ala Pro Pro Cys Ser Ser Gly Trp Tyr Tyr Phe Asp
100 105 110
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 679
<211> 125
<212> PRT
<213> Homo sapiens
<400> 679
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ser Leu Pro Val Val Pro Ala Ala Ile Gly Pro Leu Pro Ala Phe
100 105 110
Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120 125
<210> 680
<211> 128
<212> PRT
<213> Homo sapiens
<400> 680
Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly
20 25 30
Asp Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu
35 40 45
Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser
50 55 60
Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe
65 70 75 80
Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
85 90 95
Cys Ala Arg Gly Val Glu Asp Pro Val Val Pro Ala Ala Ile Pro Trp
100 105 110
Cys Trp Phe Asp Pro Trp Gly Gln Gly Thr Arg Val Thr Val Ser Ser
115 120 125
<210> 681
<211> 136
<212> PRT
<213> Homo sapiens
<400> 681
Glu Val Gln Leu Val Glu Ser Gly Val Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Phe Gly Tyr Thr Phe Thr Gly Gln
20 25 30
Asp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Ile Asn Pro Ser Ser Ala Gly Thr Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ser Val Tyr Tyr Cys
85 90 95
Arg Lys Met Leu Thr Ile Phe Gly Lys Val Asn Gln Thr Met Leu Leu
100 105 110
Ile Ser Gly Ala Lys Gly Gln Trp Ser Pro Ser Leu Gln Trp Gly Gln
115 120 125
Gly Thr Met Val Thr Val Ser Ser
130 135
<210> 682
<211> 122
<212> PRT
<213> Homo sapiens
<400> 682
Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr
20 25 30
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Ala Thr Ile Thr Thr Asp Glu Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Gly Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Thr His Ser Tyr Asp Asn Ser Gly Gln Tyr Phe Asp Tyr Trp
100 105 110
Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120
<210> 683
<211> 127
<212> PRT
<213> Homo sapiens
<400> 683
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser His
20 25 30
Trp Ile Ser Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
35 40 45
Gly Arg Ile Asp Pro Ser Asp Ser Tyr Thr Asn Tyr Ser Pro Ser Phe
50 55 60
Gln Gly His Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65 70 75 80
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
85 90 95
Ala Arg Leu Lys Val Ile Thr Ile Phe Gly Val Val Arg Asp Asp Tyr
100 105 110
Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 684
<211> 121
<212> PRT
<213> Homo sapiens
<400> 684
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ser Ala Ser Gly Ser Tyr Tyr Gly Ala Phe Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 685
<211> 121
<212> PRT
<213> Homo sapiens
<400> 685
Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Pro Glu Leu
20 25 30
Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Asp Trp Met
35 40 45
Gly Gly Phe Asp Pro Glu Asp Gly Glu Thr Ile Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Thr Ser Pro Ala Val Met Ser Val Gly Trp Val Asp Pro Trp Gly
100 105 110
Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 686
<211> 123
<212> PRT
<213> Homo sapiens
<400> 686
Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
1 5 10 15
Thr Leu Pro Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser
20 25 30
Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu
35 40 45
Trp Ile Gly Ser Val Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser
50 55 60
Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Leu
65 70 75 80
Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
85 90 95
Cys Ala Arg Gln Val Arg Gln Trp Leu Glu Asp Asp Ala Phe Asp Ile
100 105 110
Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120
<210> 687
<211> 123
<212> PRT
<213> Homo sapiens
<400> 687
Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn
20 25 30
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Val Ile Tyr Thr Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Ala His Val Asp Thr Ala Met Val Glu Ser Gly Ala Phe Asp Ile
100 105 110
Trp Gly Gln Gly Thr Arg Val Thr Val Ser Ser
115 120
<210> 688
<211> 122
<212> PRT
<213> Homo sapiens
<400> 688
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly
1 5 10 15
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser
20 25 30
Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp
35 40 45
Ile Gly Glu Ile Tyr His Ser Gly Ser Ser Asn Tyr Asn Pro Ser Leu
50 55 60
Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser
65 70 75 80
Leu Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Gly Arg Tyr Cys Ser Gly Gly Arg Cys Gly Trp Phe Asp Pro Trp
100 105 110
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 689
<211> 131
<212> PRT
<213> Homo sapiens
<400> 689
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Thr Phe Ser Asn Tyr
20 25 30
Asn Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Leu Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Val Gln Lys Asp Ile Val Val Val Pro Val Ala Leu Ala Asp
100 105 110
Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr
115 120 125
Val Ser Ser
130
<210> 690
<211> 126
<212> PRT
<213> Homo sapiens
<400> 690
Gln Val Gln Leu Val Gln Pro Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Ile Ser Ala Tyr Asn Gly Asp Thr Asn Tyr Ala Gln Lys Leu
50 55 60
Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Phe Asp Tyr Gly Tyr Pro Tyr Ser Ser Trp Ser Val Leu Ser
100 105 110
Ile Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 691
<211> 122
<212> PRT
<213> Homo sapiens
<400> 691
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Ser Tyr Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Thr Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu Gly Ser Arg Gln Trp Leu Val Ile Tyr Phe Asp Tyr Trp
100 105 110
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 692
<211> 131
<212> PRT
<213> Homo sapiens
<400> 692
Glu Val Gln Leu Leu Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr
20 25 30
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Asp Gly Asp Tyr Tyr Asp Ser Ser Gly Tyr Tyr Arg Pro
100 105 110
Thr Leu Tyr Asn Trp Leu Asp Pro Trp Gly Gln Gly Thr Arg Val Thr
115 120 125
Val Ser Ser
130
<210> 693
<211> 120
<212> PRT
<213> Homo sapiens
<400> 693
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Ala Ser Gly Gly Ser Ile Ser Ser Ser
20 25 30
Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu
35 40 45
Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser
50 55 60
Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe
65 70 75 80
Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
85 90 95
Cys Ala Arg His Pro Ser Gly Leu Tyr Gln Leu Leu Asn Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 694
<211> 128
<212> PRT
<213> Homo sapiens
<400> 694
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Lys Val Ala Thr Tyr Tyr Tyr Asp Arg Ser Gly Tyr Tyr Tyr Gly
100 105 110
Gly Ala Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 695
<211> 120
<212> PRT
<213> Homo sapiens
<400> 695
Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr
20 25 30
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
35 40 45
Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys
50 55 60
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
65 70 75 80
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Gly Pro Ala Ala Thr Tyr Tyr Tyr Tyr Met Asp Val Trp Gly Lys
100 105 110
Gly Thr Arg Val Thr Val Ser Ser
115 120
<210> 696
<211> 119
<212> PRT
<213> Homo sapiens
<400> 696
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Thr Ile Ser Gly Ser Gly Gly Asn Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Ile Ala Val Ala Gly Cys Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 697
<211> 129
<212> PRT
<213> Homo sapiens
<400> 697
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Val Gly Ser Val Lys Ser Thr Ala Gly Tyr Asp Phe Trp Ser
100 105 110
Gly Asp Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
115 120 125
Ser
<210> 698
<211> 123
<212> PRT
<213> Homo sapiens
<400> 698
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Thr Glu Leu
20 25 30
Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met
35 40 45
Gly Gly Phe Asp Pro Glu Asp Gly Glu Thr Ile Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Thr Ala Tyr Ser Val Asp Thr Ala Met Val Arg Gly Val Gly Tyr
100 105 110
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 699
<211> 125
<212> PRT
<213> Homo sapiens
<400> 699
Gln Val Gln Leu Val Glu Ser Arg Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr
20 25 30
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Arg Ile Ile Pro Ile Leu Gly Ile Thr Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Ala Pro Asp Tyr Tyr Asp Ser Ser Gly Pro Thr Tyr Phe
100 105 110
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 700
<211> 123
<212> PRT
<213> Homo sapiens
<400> 700
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Lys Ala Glu Pro Glu Val Gly Gly Tyr Asp Tyr Tyr Met Asp Val
100 105 110
Trp Gly Lys Gly Thr Met Val Thr Val Ser Ser
115 120
<210> 701
<211> 120
<212> PRT
<213> Homo sapiens
<400> 701
Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr
20 25 30
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
35 40 45
Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys
50 55 60
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
65 70 75 80
Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Gly Pro Ala Ala Thr Tyr Tyr Tyr Tyr Met Asp Val Trp Gly Lys
100 105 110
Gly Thr Met Val Thr Val Ser Ser
115 120
<210> 702
<211> 127
<212> PRT
<213> Homo sapiens
<400> 702
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Lys Met Gly Pro Asp Pro Ala His Asp Tyr Gly Arg Lys Asn Asp
100 105 110
Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120 125
<210> 703
<211> 123
<212> PRT
<213> Homo sapiens
<400> 703
Glu Val Gln Leu Val Glu Ser Arg Ala Glu Met Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asn His
20 25 30
Trp Ile Ala Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
35 40 45
Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe
50 55 60
Glu Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65 70 75 80
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
85 90 95
Ala Arg Arg Gly Tyr Thr Tyr Gly Ala Asp Phe Tyr Gly Leu Asp Val
100 105 110
Trp Gly Gln Gly Thr Arg Val Thr Val Ser Ser
115 120
<210> 704
<211> 119
<212> PRT
<213> Homo sapiens
<400> 704
Gln Met Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Gly Phe Ile Thr Tyr
20 25 30
Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
35 40 45
Gly Ile Ile Tyr Pro Gly Asp Ser Glu Thr Arg Tyr Ser Pro Ser Phe
50 55 60
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Asn Thr Ala Tyr
65 70 75 80
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Ile Tyr Tyr Cys
85 90 95
Ala Gly Gly Ser Gly Ile Ser Thr Pro Met Asp Val Trp Gly Gln Gly
100 105 110
Thr Thr Val Thr Val Ser Ser
115
<210> 705
<211> 124
<212> PRT
<213> Homo sapiens
<400> 705
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Ser Ser Gly
20 25 30
Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp
35 40 45
Ile Gly Ser Ile Tyr His Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu
50 55 60
Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser
65 70 75 80
Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Thr Pro Leu Ser Leu Arg Leu Arg Tyr Asn Trp Tyr Phe Asp
100 105 110
Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 706
<211> 112
<212> PRT
<213> Homo sapiens
<400> 706
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Asn Val Ser Gly Gly Ser Ile Ser Ser Tyr
20 25 30
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
35 40 45
Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys
50 55 60
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
65 70 75 80
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
100 105 110
<210> 707
<211> 118
<212> PRT
<213> Homo sapiens
<400> 707
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly
20 25 30
Gly Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu
35 40 45
Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser
50 55 60
Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe
65 70 75 80
Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
85 90 95
Cys Ala Arg Glu Thr Thr Gly His Phe Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Leu Val Thr Val Ser Ser
115
<210> 708
<211> 120
<212> PRT
<213> Homo sapiens
<400> 708
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Leu Ser Asn Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Leu Ile Ser Tyr Asp Gly Ser Val Lys Tyr Tyr Thr Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Val Ser Gly Asp Asn Ser Lys Asn Thr Leu Phe
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Pro Asp Asp Ser Ala Leu Tyr Tyr Cys
85 90 95
Val Arg Gly Gly Val Ser Gly Pro Asn Ser Phe Asp Met Trp Gly Gln
100 105 110
Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 709
<211> 122
<212> PRT
<213> Homo sapiens
<400> 709
Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Gln Ala Ser Gly Tyr Ser Phe Thr Asn His
20 25 30
Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Ile Asn Thr Asn Thr Gly Asn Pro Thr Tyr Ala Gln Gly Phe
50 55 60
Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Thr Tyr
65 70 75 80
Leu His Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ala Ser Ala Arg Pro Gly Val Ala Thr Asn Leu Asp Phe Trp
100 105 110
Gly Gln Gly Thr Leu Val Val Val Ser Ser
115 120
<210> 710
<211> 126
<212> PRT
<213> Homo sapiens
<400> 710
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Phe Asn Ser Tyr Gln Leu Leu Trp Tyr Tyr Tyr Tyr Gly
100 105 110
Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 711
<211> 125
<212> PRT
<213> Homo sapiens
<400> 711
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr
20 25 30
Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
35 40 45
Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe
50 55 60
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65 70 75 80
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
85 90 95
Ala Arg Gln Ser Ser Phe Tyr Ser Ser Gly Trp Tyr Ser Tyr Gly Met
100 105 110
Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 712
<211> 124
<212> PRT
<213> Homo sapiens
<400> 712
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr
20 25 30
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Val Asp Tyr Gly Ser Gly Ser Tyr Gly Trp Gly Trp Phe Asp
100 105 110
Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 713
<211> 122
<212> PRT
<213> Homo sapiens
<400> 713
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Thr Glu Leu
20 25 30
Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met
35 40 45
Gly Gly Phe Asp Pro Glu Asp Gly Glu Thr Ile Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Thr Thr Ser Pro Ile Val Gly Ala Ile Thr Trp Phe Asp Pro Trp
100 105 110
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 714
<211> 127
<212> PRT
<213> Homo sapiens
<400> 714
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr
20 25 30
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu Tyr Tyr Tyr Asp Ser Ser Val Tyr Pro Tyr Tyr Tyr Tyr
100 105 110
Ala Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 715
<211> 119
<212> PRT
<213> Homo sapiens
<400> 715
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Val Arg Gly Ser Tyr Tyr Leu Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 716
<211> 127
<212> PRT
<213> Homo sapiens
<400> 716
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala
20 25 30
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala
50 55 60
Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr
65 70 75 80
Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
85 90 95
Tyr Cys Thr Thr Asp Arg Val Tyr Asp Tyr Ile Trp Gly Ser Tyr Arg
100 105 110
Tyr Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 717
<211> 128
<212> PRT
<213> Homo sapiens
<400> 717
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Arg Glu Ser Tyr Asp Ile Leu Thr Gly Tyr Ser Met Glu
100 105 110
Gly Cys Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 718
<211> 126
<212> PRT
<213> Homo sapiens
<400> 718
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met
35 40 45
Gly Trp Ile Asn Ala Gly Asn Gly Asn Thr Lys Tyr Ser Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Val Trp Gly Tyr Cys Ser Gly Gly Ser Cys Tyr Val Asp Ala
100 105 110
Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120 125
<210> 719
<211> 122
<212> PRT
<213> Homo sapiens
<400> 719
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Thr Glu Leu
20 25 30
Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met
35 40 45
Gly Gly Phe Asp Pro Glu Asp Gly Glu Thr Ile Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Thr Ala Pro Pro Tyr Ser Pro Pro Ser Ser Trp Phe Asp Pro Trp
100 105 110
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 720
<211> 130
<212> PRT
<213> Homo sapiens
<400> 720
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly
20 25 30
Asp Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu
35 40 45
Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser
50 55 60
Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe
65 70 75 80
Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
85 90 95
Cys Ala Arg Asp His His Tyr Asp Phe Trp Ser Gly Tyr Ser Ser Tyr
100 105 110
Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val
115 120 125
Ser Ser
130
<210> 721
<211> 134
<212> PRT
<213> Homo sapiens
<400> 721
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Glu Ala Tyr Tyr Asp Ile Leu Thr Gly Tyr Ile Asn Ala
100 105 110
Pro Lys Asn Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr
115 120 125
Thr Val Thr Val Ser Ser
130
<210> 722
<211> 121
<212> PRT
<213> Homo sapiens
<400> 722
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Leu Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ser Phe Gly Gly Ser Tyr Tyr Tyr Gly Met Asp Val Trp Gly
100 105 110
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 723
<211> 122
<212> PRT
<213> Homo sapiens
<400> 723
Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Leu Ser Cys Gln Ala Ser Gly Tyr Ser Phe Thr Asn His
20 25 30
Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Ile Asn Thr Asn Thr Gly Asn Pro Thr Tyr Ala Gln Gly Phe
50 55 60
Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Thr Tyr
65 70 75 80
Leu His Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ala Ser Ala Arg Pro Gly Val Ala Thr Asn Leu Asp Phe Trp
100 105 110
Gly Gln Gly Thr Leu Val Val Val Ser Ser
115 120
<210> 724
<211> 118
<212> PRT
<213> Homo sapiens
<400> 724
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Val Ile Val Ser Ser Asn
20 25 30
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Asp Leu Asp Val Ser Gly Gly Met Asp Val Trp Gly Gln Gly Thr
100 105 110
Thr Val Thr Val Ser Ser
115
<210> 725
<211> 122
<212> PRT
<213> Homo sapiens
<400> 725
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Thr Glu Leu
20 25 30
Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met
35 40 45
Gly Gly Phe Asp Pro Glu Asp Gly Glu Thr Ile Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Thr Ala Pro Pro Tyr Ser Pro Pro Ser Ser Trp Phe Asp Pro Trp
100 105 110
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 726
<211> 122
<212> PRT
<213> Homo sapiens
<400> 726
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr
20 25 30
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Ile Asn Pro Asn Ser Asp Val Thr Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu Ala Arg Asp Tyr Tyr Gly Ser Gly Ser Leu Asp Tyr Trp
100 105 110
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 727
<211> 123
<212> PRT
<213> Homo sapiens
<400> 727
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Asp Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu
50 55 60
Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Ser Val Ala Gly Ile Tyr Tyr Tyr Tyr Gly Met Asp Val
100 105 110
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 728
<211> 121
<212> PRT
<213> Homo sapiens
<400> 728
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ser Tyr Gly Gly Ser Tyr Tyr Tyr Gly Met Asp Val Trp Gly
100 105 110
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 729
<211> 124
<212> PRT
<213> Homo sapiens
<400> 729
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Ser Ser Gly
20 25 30
Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp
35 40 45
Ile Gly Ser Ile Tyr His Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu
50 55 60
Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser
65 70 75 80
Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Thr Pro Leu Ser Leu Arg Leu Arg Tyr Asn Trp Tyr Phe Asp
100 105 110
Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 730
<211> 125
<212> PRT
<213> Homo sapiens
<400> 730
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr
20 25 30
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Val Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Asn Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Phe Cys
85 90 95
Ala Arg Asp Leu Thr Thr Thr Ala Gly Thr Asp Tyr Tyr Tyr Gly Met
100 105 110
Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 731
<211> 128
<212> PRT
<213> Homo sapiens
<400> 731
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu
50 55 60
Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ala Arg Val Ala Tyr Asp Tyr Ile Trp Gly Ser Tyr Arg Tyr
100 105 110
Lys Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 732
<211> 121
<212> PRT
<213> Homo sapiens
<400> 732
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ala Gln Thr Ala His Tyr Ser Ser Ser Phe Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 733
<211> 120
<212> PRT
<213> Homo sapiens
<400> 733
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Met Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Leu Ser Ser Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Leu Ile Ser Tyr Asp Gly Ser Ile Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Val Ser Gly Asp Asn Ser Lys Asn Thr Leu Phe
65 70 75 80
Leu Gln Met Ser Ser Leu Arg Ala Asp Asp Ser Ala Leu Tyr Tyr Cys
85 90 95
Val Arg Gly Gly Val Ser Gly Pro Asn Ala Phe Asp Ile Trp Gly Gln
100 105 110
Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 734
<211> 121
<212> PRT
<213> Homo sapiens
<400> 734
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ser Ile Ser Gly Ser Tyr Leu Gly Ala Phe Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 735
<211> 123
<212> PRT
<213> Homo sapiens
<400> 735
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Ser Tyr
20 25 30
Gly Ile Ser Trp Val Arg Gln Asp Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu
50 55 60
Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Val Gly Leu Trp Trp Leu Gly His Pro Asp Ala Phe Asp Ile
100 105 110
Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120
<210> 736
<211> 121
<212> PRT
<213> Homo sapiens
<400> 736
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Thr Lys Gly Gly Ser Tyr Phe Ala Pro Phe Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 737
<211> 122
<212> PRT
<213> Homo sapiens
<400> 737
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Val
50 55 60
Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Arg Gly Tyr Ala Ala Thr Phe Gly Val Phe Asp Tyr Trp
100 105 110
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 738
<211> 117
<212> PRT
<213> Homo sapiens
<400> 738
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Val Thr Val Val His Phe Asp Tyr Trp Gly Gln Gly Thr Leu
100 105 110
Val Thr Val Ser Ser
115
<210> 739
<211> 127
<212> PRT
<213> Homo sapiens
<400> 739
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Leu Thr Ser Thr Ser Ser Ser Pro Tyr Ser Tyr Tyr Tyr
100 105 110
Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 740
<211> 129
<212> PRT
<213> Homo sapiens
<400> 740
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu
50 55 60
Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Val Thr Val Glu Ala Ile Phe Gly Val Val Ile Leu Pro Leu
100 105 110
Lys Asn Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser
115 120 125
Ser
<210> 741
<211> 120
<212> PRT
<213> Homo sapiens
<400> 741
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Leu Ser Asn Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Leu Ile Ser Tyr Asp Gly Ser Ile Lys Tyr Tyr Thr Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Val Ser Gly Asp Asn Ser Lys Asn Thr Leu Phe
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Pro Asp Asp Ser Ala Leu Tyr Tyr Cys
85 90 95
Val Arg Gly Gly Val Ser Gly Pro Asn Ser Phe Asp Met Trp Gly Gln
100 105 110
Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 742
<211> 123
<212> PRT
<213> Homo sapiens
<400> 742
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Ile Ser Ala Tyr Ser Gly Asn Thr Asn Tyr Ala Gln Lys Leu
50 55 60
Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Val Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Val Gly Leu Trp Trp Leu Gly His Pro Asp Val Phe Asp Ile
100 105 110
Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120
<210> 743
<211> 125
<212> PRT
<213> Homo sapiens
<400> 743
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr
20 25 30
Thr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Leu Val Glu Asp Thr Ala Met Val Thr Gly Ala Ala Ala
100 105 110
Gly Thr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 744
<211> 124
<212> PRT
<213> Homo sapiens
<400> 744
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Thr Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Tyr Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Ile Ile Asn Pro Ser Gly Gly Thr Thr Ser Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ala Gly Arg Arg Tyr Ser Ser Ser Asp Asp Gly Ala Phe Asp
100 105 110
Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120
<210> 745
<211> 124
<212> PRT
<213> Homo sapiens
<400> 745
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Ile Met Phe Gly Asp Asp Trp Leu Gln Lys Gln Pro Asp
100 105 110
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 746
<211> 121
<212> PRT
<213> Homo sapiens
<400> 746
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ser Ile Ser Gly Ser Tyr Leu Gly Ala Phe Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 747
<211> 132
<212> PRT
<213> Homo sapiens
<400> 747
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu
50 55 60
Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Leu Val Pro Thr Trp Ala Ser Tyr Tyr Asp Phe Trp Ser Gly
100 105 110
Tyr Pro Gly Gly Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val
115 120 125
Thr Val Ser Ser
130
<210> 748
<211> 125
<212> PRT
<213> Homo sapiens
<400> 748
Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser
20 25 30
Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu
35 40 45
Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser
50 55 60
Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe
65 70 75 80
Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
85 90 95
Cys Ala Thr His Ile Val Val Val Thr Ala Thr Pro Asn Trp Tyr Phe
100 105 110
Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 749
<211> 121
<212> PRT
<213> Homo sapiens
<400> 749
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Ala Phe Thr Phe Ser Ser Tyr
20 25 30
Asp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Asp Gly Gly Lys Leu Trp Val Tyr Tyr Phe Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 750
<211> 122
<212> PRT
<213> Homo sapiens
<400> 750
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr
20 25 30
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Thr Gln Met Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr
65 70 75 80
Met Glu Val Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Arg Ser Trp Ala Val Val Tyr Tyr Tyr Met Asp Val Trp
100 105 110
Gly Lys Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 751
<211> 138
<212> PRT
<213> Homo sapiens
<400> 751
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Asp Ile Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Met Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Arg Asn Thr Ser Ile Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ala Thr Thr Asp Cys Ser Ser Thr Ser Cys Trp Ser Leu Asp
100 105 110
Phe Trp Ser Gly Tyr Tyr Thr Gly Gly Arg Glu Lys Ile Phe Asp Trp
115 120 125
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
130 135
<210> 752
<211> 118
<212> PRT
<213> Homo sapiens
<400> 752
Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Leu Arg Phe
20 25 30
Ala Met Asn Trp Leu Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Ile Asp Thr Asn Thr Gly Thr Pro Thr Tyr Ala Gln Gly Phe
50 55 60
Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr
65 70 75 80
Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ser Leu Arg Gly Ala Asn Leu Val Pro Trp Gly Gln Gly Thr
100 105 110
Leu Val Thr Val Ser Ser
115
<210> 753
<211> 118
<212> PRT
<213> Homo sapiens
<400> 753
Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Leu Arg Phe
20 25 30
Ala Met Asn Trp Leu Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Ile Asp Thr Asn Thr Gly Thr Pro Thr Tyr Ala Gln Gly Phe
50 55 60
Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr
65 70 75 80
Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ser Leu Arg Gly Ala Asn Leu Val Pro Trp Gly Gln Gly Thr
100 105 110
Leu Val Thr Val Ser Ser
115
<210> 754
<211> 127
<212> PRT
<213> Homo sapiens
<400> 754
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Met Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Arg Thr Phe Ser Thr Ala
20 25 30
Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val
35 40 45
Ala Ala Ile Arg Trp Ser Gly Gly Ser Ala Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Tyr Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Thr Glu Asn Val Arg Ser Leu Leu Ser Asp Tyr Ala Thr Trp
100 105 110
Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120 125
<210> 755
<211> 127
<212> PRT
<213> Homo sapiens
<400> 755
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Met Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Arg Thr Phe Ser Thr Ala
20 25 30
Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val
35 40 45
Ala Ala Ile Arg Trp Ser Gly Gly Ser Ala Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Tyr Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Gln Thr His Tyr Val Ser Tyr Leu Leu Ser Asp Tyr Ala Thr Trp
100 105 110
Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120 125
<210> 756
<211> 126
<212> PRT
<213> Homo sapiens
<400> 756
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr
20 25 30
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Arg Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Val Pro Tyr Cys Ser Ser Thr Ser Cys His Arg Asp Trp Tyr
100 105 110
Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 757
<211> 126
<212> PRT
<213> Homo sapiens
<400> 757
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Trp Tyr Asp Gly Arg Asn Lys Tyr Tyr Val Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Ile Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ala Ala Arg Arg Pro Val Val Thr Asp Thr Met Ala Tyr Tyr
100 105 110
Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 758
<211> 123
<212> PRT
<213> Homo sapiens
<400> 758
Gln Met Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Thr
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Ser Ser
20 25 30
Ala Val Gln Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Ile
35 40 45
Gly Trp Ile Val Val Gly Ser Gly Asn Thr Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Glu Arg Val Thr Ile Thr Arg Asp Met Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ala Pro His Cys Ser Ser Thr Ile Cys Tyr Asp Gly Phe Asp Ile
100 105 110
Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120
<210> 759
<211> 120
<212> PRT
<213> Homo sapiens
<400> 759
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Thr Gly Phe Thr Phe Arg Arg Tyr
20 25 30
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Gly Ile Leu Phe Asp Gly Ser Asn Lys Tyr Tyr Val Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Ser Arg Asn Thr Leu Tyr
65 70 75 80
Leu Gln Leu Asn Ser Leu Arg Arg Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Gly Asp Tyr Glu Trp Glu Leu Leu Glu Ser Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 760
<211> 117
<212> PRT
<213> Homo sapiens
<400> 760
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn
20 25 30
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Asp Phe Gly Asp Phe Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu
100 105 110
Val Thr Val Ser Ser
115
<210> 761
<211> 117
<212> PRT
<213> Homo sapiens
<400> 761
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Val Ser Ser Asn
20 25 30
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Asp Tyr Gly Asp Tyr Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu
100 105 110
Val Thr Val Ser Ser
115
<210> 762
<211> 123
<212> PRT
<213> Homo sapiens
<400> 762
Gln Met Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Thr
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Ser Ser Ser
20 25 30
Ala Val Gln Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Ile
35 40 45
Gly Trp Ile Val Val Gly Ser Gly Asn Thr Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Ile Thr Arg Asp Met Ser Thr Arg Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys
85 90 95
Ala Ala Pro Tyr Cys Ser Ser Thr Arg Cys Tyr Asp Ala Phe Asp Ile
100 105 110
Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120
<210> 763
<211> 125
<212> PRT
<213> Homo sapiens
<400> 763
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Gly Leu Tyr Tyr Cys
85 90 95
Ala Lys Asp Ile Asn Tyr Asp Ser Gly Gly Tyr His Lys Asn Tyr Phe
100 105 110
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 764
<211> 125
<212> PRT
<213> Lama pacos
<400> 764
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ser Ser Ile Thr
20 25 30
Tyr Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val
35 40 45
Ala Ala Leu Ile Thr Asp Ser Gly Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Val Ser Leu Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Ala Ala Glu Trp Gly Tyr Glu Trp Pro Leu Tyr Tyr Ala Ser Ser
100 105 110
Trp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120 125
<210> 765
<211> 125
<212> PRT
<213> Lama pacos
<400> 765
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ser Ser Ile Thr
20 25 30
Tyr Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val
35 40 45
Ala Ala Leu Ile Thr Asp Ser Gly Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Val Ser Leu Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Ala Ala Glu Trp Gly Tyr Glu Trp Pro Leu Tyr Tyr Ala Ser Ser
100 105 110
Trp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120 125
<210> 766
<211> 125
<212> PRT
<213> Lama pacos
<400> 766
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ser Ser Ile Thr
20 25 30
Tyr Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val
35 40 45
Ala Ala Leu Ile Thr Asp Ser Gly Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Val Ser Leu Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Ala Ala Glu Trp Gly Tyr Glu Trp Pro Leu Tyr Tyr Ala Ser Ser
100 105 110
Trp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120 125
<210> 767
<211> 125
<212> PRT
<213> Lama pacos
<400> 767
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ser Ser Ile Thr
20 25 30
Tyr Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val
35 40 45
Ala Ala Leu Ile Thr Asp Ser Gly Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Val Ser Leu Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Ala Ala Glu Trp Gly Tyr Glu Trp Pro Leu Tyr Tyr Ala Ser Ser
100 105 110
Trp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120 125
<210> 768
<211> 125
<212> PRT
<213> Lama pacos
<400> 768
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ser Ser Ile Thr
20 25 30
Tyr Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val
35 40 45
Ala Ala Leu Ile Thr Asp Ser Gly Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Val Ser Leu Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Ala Ala Glu Trp Gly Tyr Glu Trp Pro Leu Tyr Tyr Ala Ser Ser
100 105 110
Trp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120 125
<210> 769
<211> 125
<212> PRT
<213> Lama pacos
<400> 769
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ser Ser Ile Thr
20 25 30
Tyr Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val
35 40 45
Ala Ala Leu Ile Thr Asp Ser Gly Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Val Ser Leu Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Ala Ala Glu Trp Gly Tyr Glu Trp Pro Leu Tyr Tyr Ala Ser Ser
100 105 110
Trp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120 125
<210> 770
<211> 125
<212> PRT
<213> Lama pacos
<400> 770
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ser Ser Ile Thr
20 25 30
Tyr Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val
35 40 45
Ala Ala Leu Ile Thr Asp Ser Gly Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Val Ser Leu Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Ala Ala Glu Trp Gly Tyr Glu Trp Pro Leu Tyr Tyr Ala Ser Ser
100 105 110
Trp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120 125
<210> 771
<211> 125
<212> PRT
<213> Lama pacos
<400> 771
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ser Ser Ile Thr
20 25 30
Tyr Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val
35 40 45
Ala Ala Leu Ile Thr Asp Ser Gly Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Val Ser Leu Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Ala Ala Glu Trp Gly Tyr Glu Trp Pro Leu Tyr Tyr Ala Ser Ser
100 105 110
Trp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120 125
<210> 772
<211> 125
<212> PRT
<213> Lama pacos
<400> 772
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ser Ser Ile Thr
20 25 30
Tyr Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val
35 40 45
Ala Ala Leu Ile Thr Asp Ser Gly Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Val Ser Leu Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Ala Ala Glu Trp Gly Tyr Glu Trp Pro Leu Tyr Tyr Ala Ser Ser
100 105 110
Trp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120 125
<210> 773
<211> 125
<212> PRT
<213> Lama pacos
<400> 773
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ser Ser Ile Thr
20 25 30
Tyr Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val
35 40 45
Ala Ala Leu Ile Thr Asp Ser Gly Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Val Ser Leu Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Ala Ala Glu Trp Gly Tyr Glu Trp Pro Leu Tyr Tyr Ala Ser Ser
100 105 110
Trp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120 125
<210> 774
<211> 125
<212> PRT
<213> Homo sapiens
<400> 774
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ser Ser Ile Thr
20 25 30
Tyr Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val
35 40 45
Ala Ala Leu Ile Thr Asp Ser Gly Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Val Ser Leu Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Ala Ala Glu Trp Gly Tyr Glu Trp Pro Leu Tyr Tyr Ala Ser Ser
100 105 110
Trp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120 125
<210> 775
<211> 125
<212> PRT
<213> Homo sapiens
<400> 775
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ser Ser Ile Thr
20 25 30
Tyr Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val
35 40 45
Ala Ala Leu Ile Thr Asp Ser Gly Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Val Ser Leu Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Ala Ala Glu Trp Gly Tyr Glu Trp Pro Leu Tyr Tyr Ala Ser Ser
100 105 110
Trp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120 125
<210> 776
<211> 125
<212> PRT
<213> Homo sapiens
<400> 776
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ser Ser Ile Thr
20 25 30
Tyr Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val
35 40 45
Ala Ala Leu Ile Thr Asp Ser Gly Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Val Ser Leu Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Ala Ala Glu Trp Gly Tyr Glu Trp Pro Leu Tyr Tyr Ala Ser Ser
100 105 110
Trp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120 125
<210> 777
<211> 125
<212> PRT
<213> Homo sapiens
<400> 777
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ser Ser Ile Thr
20 25 30
Tyr Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val
35 40 45
Ala Ala Leu Ile Thr Asp Ser Gly Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Val Ser Leu Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Ala Ala Glu Trp Gly Tyr Glu Trp Pro Leu Tyr Tyr Ala Ser Ser
100 105 110
Trp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120 125
<210> 778
<211> 125
<212> PRT
<213> Homo sapiens
<400> 778
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ser Ser Ile Thr
20 25 30
Tyr Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val
35 40 45
Ala Ala Leu Ile Thr Asp Ser Gly Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Val Ser Leu Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Ala Ala Glu Trp Gly Tyr Glu Trp Pro Leu Tyr Tyr Ala Ser Ser
100 105 110
Trp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120 125
<210> 779
<211> 125
<212> PRT
<213> Homo sapiens
<400> 779
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ser Ser Ile Thr
20 25 30
Tyr Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val
35 40 45
Ala Ala Leu Ile Thr Asp Ser Gly Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Val Ser Leu Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Ala Ala Glu Trp Gly Tyr Glu Trp Pro Leu Tyr Tyr Ala Ser Ser
100 105 110
Trp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120 125
<210> 780
<211> 125
<212> PRT
<213> Homo sapiens
<400> 780
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ser Ser Ile Thr
20 25 30
Tyr Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val
35 40 45
Ala Ala Leu Ile Thr Asp Ser Gly Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Val Ser Leu Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Ala Ala Glu Trp Gly Tyr Glu Trp Pro Leu Tyr Tyr Ala Ser Ser
100 105 110
Trp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120 125
<210> 781
<211> 125
<212> PRT
<213> Homo sapiens
<400> 781
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ser Ser Ile Thr
20 25 30
Tyr Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val
35 40 45
Ala Ala Leu Ile Thr Asp Ser Gly Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Val Ser Leu Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Ala Ala Glu Trp Gly Tyr Glu Trp Pro Leu Tyr Tyr Ala Ser Ser
100 105 110
Trp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120 125
<210> 782
<211> 125
<212> PRT
<213> Homo sapiens
<400> 782
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ser Ser Ile Thr
20 25 30
Tyr Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val
35 40 45
Ala Ala Leu Ile Thr Asp Ser Gly Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Val Ser Leu Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Ala Ala Glu Trp Gly Tyr Glu Trp Pro Leu Tyr Tyr Ala Ser Ser
100 105 110
Trp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120 125
<210> 783
<211> 125
<212> PRT
<213> Homo sapiens
<400> 783
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ser Ser Ile Thr
20 25 30
Tyr Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val
35 40 45
Ala Ala Leu Ile Thr Asp Ser Gly Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Val Ser Leu Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Ala Ala Glu Trp Gly Tyr Glu Trp Pro Leu Tyr Tyr Ala Ser Ser
100 105 110
Trp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120 125
<210> 784
<211> 125
<212> PRT
<213> Homo sapiens
<400> 784
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ser Ser Ile Thr
20 25 30
Tyr Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val
35 40 45
Ala Ala Leu Ile Thr Asp Ser Gly Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Val Ser Leu Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Ala Ala Glu Trp Gly Tyr Glu Trp Pro Leu Tyr Tyr Ala Ser Ser
100 105 110
Trp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120 125
<210> 785
<211> 125
<212> PRT
<213> Homo sapiens
<400> 785
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ser Ser Ile Thr
20 25 30
Tyr Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val
35 40 45
Ala Ala Leu Ile Thr Asp Ser Gly Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Val Ser Leu Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Ala Ala Glu Trp Gly Tyr Glu Trp Pro Leu Tyr Tyr Ala Ser Ser
100 105 110
Trp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120 125
<210> 786
<211> 125
<212> PRT
<213> Homo sapiens
<400> 786
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ser Ser Ile Thr
20 25 30
Tyr Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val
35 40 45
Ala Ala Leu Ile Thr Asp Ser Gly Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Val Ser Leu Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Ala Ala Glu Trp Gly Tyr Glu Trp Pro Leu Tyr Tyr Ala Ser Ser
100 105 110
Trp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120 125
<210> 787
<211> 116
<212> PRT
<213> Homo sapiens
<400> 787
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Val Gly Ser Gly Arg Val Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 788
<211> 130
<212> PRT
<213> Homo sapiens
<400> 788
Gln Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gly
1 5 10 15
Thr Leu Ser Val Thr Cys Ala Val Ser Gly Asp Ser Ile Ser Ser Asp
20 25 30
Tyr Trp Cys Thr Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp
35 40 45
Ile Gly Lys Ile Ser His Ser Gly Ser Leu Asn Tyr Asn Pro Ser Leu
50 55 60
Lys Ser Arg Val Thr Met Ser Val Asp Lys Ser Lys Asn His Phe Ser
65 70 75 80
Leu Lys Leu Ala Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Val Arg Ile Gly Ala Ser His His Asn Phe Trp Ser Gly Tyr
100 105 110
Tyr Thr Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Thr Val Thr Val
115 120 125
Ser Ser
130
<210> 789
<211> 128
<212> PRT
<213> Homo sapiens
<400> 789
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asn Tyr
20 25 30
Trp Val Gly Trp Val Arg Gln Met Pro Ala Lys Gly Leu Glu Trp Met
35 40 45
Gly Ile Ile Trp Pro Asp Asp Ser Asp Thr Arg Tyr Arg Pro Ser Phe
50 55 60
Gln Gly Gln Val Thr Ile Ser Val Asp Lys Ser Ile Ser Thr Ala Tyr
65 70 75 80
Leu His Trp Asn Ser Leu Lys Ala Ser Asp Asn Gly Met Tyr Phe Cys
85 90 95
Ala Arg Ala Pro Leu Ala Ser Cys Ser Gly Gly Arg Cys Pro Thr Tyr
100 105 110
Asn Arg Phe Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 790
<211> 125
<212> PRT
<213> Homo sapiens
<400> 790
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Met Lys Val Ser Cys Lys Ala Ser Gly Val Asn Phe Arg Ser Tyr
20 25 30
Ser Phe Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Val Ile Pro Tyr Phe Pro Thr Ala Asn Tyr Ala Asp Lys Phe
50 55 60
Arg Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Gly Thr Val Tyr
65 70 75 80
Leu Asp Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys
85 90 95
Ala Ser Glu Tyr Phe Asp Gly Arg Ser Tyr His Ser Phe Cys Gly Leu
100 105 110
Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 791
<211> 123
<212> PRT
<213> Homo sapiens
<400> 791
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr
20 25 30
Ala Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Lys Trp Val
35 40 45
Ser Gly Ile Asn Pro Ser Gly Asp Ala Thr Phe Tyr Thr Asp Ser Val
50 55 60
Lys Gly Gln Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ile Leu Tyr
65 70 75 80
Leu Gln Met Asn Arg Leu Arg Ala Asp Asp Thr Ala Ile Tyr Tyr Cys
85 90 95
Ala Lys Gly Leu Ser Phe Tyr Gly Ser Gly Ser Asp Ala Phe Asp Val
100 105 110
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 792
<211> 124
<212> PRT
<213> Homo sapiens
<400> 792
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Tyr Val His Trp Val Arg Gln Val Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Ile Ser Pro Asp Ser Gly Asp Thr Ile Arg Ala Gln Asn Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Met Asn Thr Ala Tyr
65 70 75 80
Met Glu Val Asn Arg Leu Arg Thr Asp Asp Thr Ala Ile Tyr Tyr Cys
85 90 95
Ala Arg Asp Leu Ile Ser Val Ile Arg Gly Leu Gly Gly Gly Met Asp
100 105 110
Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 793
<211> 126
<212> PRT
<213> Homo sapiens
<400> 793
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Gly His
20 25 30
Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Ile Asn Pro Ala Ser Gly Asp Thr Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Lys Thr Arg Asp Thr Ser Ile Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu Asn Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Gly Pro Leu Pro Trp Ser Asp Leu Asp Ile Val Gly Thr
100 105 110
Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 794
<211> 125
<212> PRT
<213> Homo sapiens
<400> 794
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Lys
1 5 10 15
Ser Leu Arg Leu Ser Cys Val Pro Ser Gly Phe Ser Phe Gly Thr Tyr
20 25 30
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Leu
35 40 45
Ala Val Met Trp Tyr Asp Gly Ile Thr Gln Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Glu Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Thr Ala Asp Asp Thr Gly Ile Tyr Tyr Cys
85 90 95
Val Lys Asp Gln Ser Ser Gly Asp Arg Leu Leu Tyr Leu Gly Tyr Phe
100 105 110
Asp Leu Trp Gly Pro Gly Ala Leu Val Thr Val Ser Ser
115 120 125
<210> 795
<211> 125
<212> PRT
<213> Homo sapiens
<400> 795
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Lys
1 5 10 15
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Ser Phe Gly Thr Tyr
20 25 30
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Leu
35 40 45
Ala Val Met Trp Tyr Asp Gly Ile Thr Gln Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Glu Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Thr Ala Asp Asp Thr Gly Val Tyr Tyr Cys
85 90 95
Val Lys Asp Gln Ser Ser Gly Asp Arg Leu Leu Tyr Leu Gly Tyr Phe
100 105 110
Asp Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 796
<211> 127
<212> PRT
<213> Homo sapiens
<400> 796
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly
1 5 10 15
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Ala Ser Val Ser Ser Asp
20 25 30
His Trp Trp Ser Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp
35 40 45
Ile Gly Glu Val Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu
50 55 60
Lys Ser Arg Val Thr Ile Ser Leu Asp Gln Ser Asn Asn Gln Phe Ser
65 70 75 80
Leu Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr Cys
85 90 95
Ala Thr Met Trp Gly Gly Leu Cys Thr Ala Ser Asn Cys Tyr Gly Asn
100 105 110
Pro Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 797
<211> 129
<212> PRT
<213> Homo sapiens
<400> 797
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Arg Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Thr His
20 25 30
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Arg Pro Glu Trp Met
35 40 45
Gly Gly Ile Met Pro Ile Phe Gly Glu Ser Lys Asp Thr Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Phe Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Ile Tyr Tyr Cys
85 90 95
Val Arg Asp Ser Asp Pro Tyr Thr Ala Thr Val Thr Ser Asn His Tyr
100 105 110
Trp Tyr Ala Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser
115 120 125
Ser
<210> 798
<211> 128
<212> PRT
<213> Homo sapiens
<400> 798
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Val Leu Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Arg Gly Phe
20 25 30
Phe Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
35 40 45
Gly Gln Ile Thr His Ser Gly Ser Thr Asn Tyr Asn Ser Ser Leu Lys
50 55 60
Ser Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
65 70 75 80
Asn Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr Cys Ala
85 90 95
Arg Gly Gln Gly Gly Tyr Asp Leu Arg Arg Val Gly Tyr Gly Leu Thr
100 105 110
Ser Trp Phe Asp Pro Trp Gly Gln Gly Ile Leu Val Thr Val Ser Ser
115 120 125
<210> 799
<211> 127
<212> PRT
<213> Homo sapiens
<400> 799
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu
35 40 45
Gly Val Ile His Pro Ser Gly Gly Ser Thr Thr Phe Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65 70 75 80
Met Glu Leu Gly Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Val Leu Ala Gly Ser Ser His Glu Trp Gln Leu Thr His Asp
100 105 110
Ala Phe Asp Ile Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 800
<211> 124
<212> PRT
<213> Homo sapiens
<400> 800
Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Ile Leu Ser Cys Lys Ala Ser Gly Tyr Thr Val Thr Asn Tyr
20 25 30
Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Ile Asp Pro Asp Ser Gly Val Thr Asn Phe Ala Glu Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Trp Leu Glu Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Asp Leu Ile Thr Val Ile Arg Gly Leu Gly Gly Gly Met Asp
100 105 110
Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 801
<211> 122
<212> PRT
<213> Homo sapiens
<400> 801
Glu Val Gln Leu Leu Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Asp
20 25 30
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile Ile Pro Ile Phe Gly Thr Thr Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Asn Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Gly Pro Tyr Asp Ser Gly Gly Tyr His Leu Asn His Trp
100 105 110
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 802
<211> 120
<212> PRT
<213> Homo sapiens
<400> 802
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Asn Pro Gly Gly
1 5 10 15
Ser Met Arg Leu Ser Cys Ala Gly Ser Gly Phe Thr Phe Ser Asp His
20 25 30
Tyr Met Gly Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Val Ile
35 40 45
Ser Tyr Ile Ser Ser Ser Gly Ser Phe Ile Arg Asp Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Met Gly Pro Tyr Gly Ser Gly Thr Phe Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 803
<211> 124
<212> PRT
<213> Homo sapiens
<400> 803
Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Arg Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Thr Gly Gly Thr Phe Ser Ser Tyr
20 25 30
Gly Ile Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Arg Ile Ile Pro Thr Leu Gly Arg Thr Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala His
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Leu Ser Thr Leu Gln Pro Asp Ala Ile Val Asn Phe Asp
100 105 110
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 804
<211> 123
<212> PRT
<213> Homo sapiens
<400> 804
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Thr Ser Gly Gly Ser Phe Thr Ser Tyr
20 25 30
Val Leu Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Arg Ile Val Pro Asn Leu Gly Val Ala Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Thr Thr Ala Tyr
65 70 75 80
Leu Glu Leu Arg Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Leu Tyr Tyr Asp Asn Gly Gly Tyr Asn Tyr Leu Asp Tyr
100 105 110
Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 805
<211> 127
<212> PRT
<213> Homo sapiens
<400> 805
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr
20 25 30
Asn Met Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
35 40 45
Ser Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu His
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Val Arg Asp Tyr Cys Asn Ser Val Ser Cys Tyr Thr Tyr Tyr Tyr Ile
100 105 110
Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 806
<211> 123
<212> PRT
<213> Homo sapiens
<400> 806
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Ser Thr Asn Tyr
20 25 30
Gly Phe Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Ile Ser Val His Ser Gly Asn Ala Asn Phe Ala Gln Lys Phe
50 55 60
Gln Gly Arg Ile Thr Met Thr Thr Asp Thr Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Asn Leu Arg Ser Asp Asp Thr Ala Thr Tyr Tyr Cys
85 90 95
Ala Thr Ser Ala Ser Ser Tyr Ser Arg Tyr Tyr Phe Gly Leu Asp Val
100 105 110
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 807
<211> 126
<212> PRT
<213> Homo sapiens
<400> 807
Glu Val Gln Leu Leu Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Asn Gly Phe Ile Ser Ser Gly
20 25 30
Glu Tyr Tyr Trp Ser Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu
35 40 45
Trp Ile Gly Tyr Ile Ser His Ser Gly Ser Thr Tyr Tyr Asn Arg Ser
50 55 60
Leu Lys Ser Arg Val Thr Ile Ser Leu Asp Thr Ser Arg Asn Gln Phe
65 70 75 80
Ser Leu Asn Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
85 90 95
Cys Ala Arg Asp Leu Ala Lys Trp Ser Tyr Gly Tyr Tyr Tyr Ser Gly
100 105 110
Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 808
<211> 124
<212> PRT
<213> Homo sapiens
<400> 808
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ile Ser Gly Gly Thr Phe Lys Asn Ser
20 25 30
Ala Phe Ser Trp Ala Arg Gln Val Pro Gly Gln Gly Phe Gln Trp Met
35 40 45
Gly Gly Ile Ile Pro Met Phe Gly Val Pro His Ser Val Gln Met Phe
50 55 60
Gln Gly Arg Val Thr Leu Thr Ala Asp Glu Ser Thr Ser Ala Val Tyr
65 70 75 80
Met Glu Leu Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu Glu Tyr Ser Gly Thr Val His Asn Phe Phe Gly Met Asp
100 105 110
Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 809
<211> 125
<212> PRT
<213> Homo sapiens
<400> 809
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His Trp Val Arg Gln Val Pro Gly Arg Gly Leu Glu Trp Val
35 40 45
Ser Gly Ile Ser Trp Asn Ser Gly Thr Ile Asn Tyr Ala Asp Ser Val
50 55 60
Met Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Lys Asp Gly Arg Tyr Cys Ser Gly Ile Ser Cys Arg Thr Gly Met
100 105 110
Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 810
<211> 121
<212> PRT
<213> Homo sapiens
<400> 810
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Glu
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Phe Ser Pro Tyr
20 25 30
Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
35 40 45
Ala Tyr Ile Ile Ser Gly Ser Gly Thr Ile Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Gln Ser Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Leu Leu Asp Tyr Leu His Asp Ala Phe Asp Ile Trp Gly
100 105 110
Gln Gly Thr Met Val Thr Val Ser Ser
115 120
<210> 811
<211> 123
<212> PRT
<213> Homo sapiens
<400> 811
Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Val Ser Ser Asp
20 25 30
Thr Asp Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu
35 40 45
Trp Ile Gly Ser Ile His Asp Ser Glu Arg Thr Tyr Tyr Asp Pro Ser
50 55 60
Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe
65 70 75 80
Ser Leu Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Leu Tyr Phe
85 90 95
Cys Ala Ser Arg His Leu Asp Leu Leu Pro Ile Gly Ser Phe Asp Val
100 105 110
Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser
115 120
<210> 812
<211> 125
<212> PRT
<213> Homo sapiens
<400> 812
Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Arg Phe Gly Asp Tyr
20 25 30
Thr Met Thr Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Gly Phe Ile Arg Ser Ile Ala Tyr Gly Gly Thr Thr Glu His Ala Ala
50 55 60
Ser Val Glu Gly Arg Phe Ile Ile Ser Arg Asp Asp Ser Lys Ser Ile
65 70 75 80
Ala Tyr Leu Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Gly Val Tyr
85 90 95
Phe Cys Thr Arg Gly Ser Gly Met Phe Tyr Gly Ser Ser Ser Gly Met
100 105 110
Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 813
<211> 121
<212> PRT
<213> Homo sapiens
<400> 813
Glu Val Gln Leu Leu Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Thr Ser Gly Gly Thr Phe Asn Ser Tyr
20 25 30
Thr Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile Ile Pro Ile Leu Asp Thr Pro His Tyr Ala Gln Lys Phe
50 55 60
Arg Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Phe
65 70 75 80
Met Asp Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ile Arg Arg Asp Tyr Ser Asp Tyr Arg Asp Phe Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 814
<211> 121
<212> PRT
<213> Homo sapiens
<400> 814
Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Ala Cys Thr Val Ser Gly Gly Ser Ile Ser Asn Tyr
20 25 30
Tyr Trp Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
35 40 45
Gly Asn Ile Tyr Tyr Ser Gly Ser Thr Thr Phe Asn Pro Ser Leu Lys
50 55 60
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Arg Asn Gln Phe Ser Leu
65 70 75 80
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Gln Ser Ser Ser Trp Tyr Asn Pro Tyr Tyr Phe Asp Gln Trp Gly
100 105 110
Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 815
<211> 121
<212> PRT
<213> Homo sapiens
<400> 815
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Glu
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Phe Ser Pro Tyr
20 25 30
Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
35 40 45
Ala Tyr Ile Ile Ser Gly Ser Gly Thr Ile Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Gln Ser Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Leu Leu Asp Tyr Leu His Asp Ala Phe Asp Ile Trp Gly
100 105 110
Gln Gly Thr Met Val Thr Val Ser Ser
115 120
<210> 816
<211> 126
<212> PRT
<213> Homo sapiens
<400> 816
Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Asn Pro Gly Ser
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ser Ser Gly Gly Thr Leu Gly Asp Tyr
20 25 30
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Leu Gly Leu Glu Trp Leu
35 40 45
Gly Gly Ile Met Pro Leu His Gly Thr Thr Gly Tyr Ser Gln Arg Phe
50 55 60
Arg Pro Arg Leu Thr Ile Thr Ala Asp Glu Ser Ala Arg Thr Ala Tyr
65 70 75 80
Met Glu Leu Thr Ala Leu Ser Ser Glu Asp Ser Ala Ile Tyr Tyr Cys
85 90 95
Ala Arg Asp Pro Ser Ile Leu Asn Thr Gly Asn His His Trp Tyr Asp
100 105 110
Leu Asp Leu Trp Gly Gln Gly Thr Glu Val Thr Val Ser Ser
115 120 125
<210> 817
<211> 121
<212> PRT
<213> Homo sapiens
<400> 817
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Tyr
20 25 30
Ala Leu Phe Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Val Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ser Val Tyr Tyr Cys
85 90 95
Ala Arg Pro Arg Ser Gly Ser Tyr Arg Gln Ala Ile Asp Tyr Trp Gly
100 105 110
Leu Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 818
<211> 123
<212> PRT
<213> Homo sapiens
<400> 818
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Gly His
20 25 30
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Asn Ile Lys Gln Asp Gly Arg Glu Lys His Tyr Val Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Val Ser
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Val Arg Gln Asn Val Ala Ile Gln Tyr Tyr Tyr Tyr Ala Met Asp Val
100 105 110
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 819
<211> 121
<212> PRT
<213> Homo sapiens
<400> 819
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr
20 25 30
Pro Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Leu Ile Ser Phe Asp Gly Asp Ser Lys Tyr Tyr Thr Asp Ser Val
50 55 60
Lys Ala Arg Phe Ala Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Val Ala Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Arg Ala Lys Gly Gly Ser Tyr Ser Asn Ala Phe Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 820
<211> 126
<212> PRT
<213> Homo sapiens
<400> 820
Gln Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Leu Ser Asp Tyr
20 25 30
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile Met Pro Ile Phe Gly Ser Pro Gly Tyr Ala Glu Ile Phe
50 55 60
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Lys Ser Thr Val Tyr
65 70 75 80
Met Glu Leu Thr Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Pro Ser Ile Leu Asp Thr Gly Asn His His Trp Tyr Asp
100 105 110
Leu Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120 125
<210> 821
<211> 124
<212> PRT
<213> Homo sapiens
<400> 821
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Thr Ser Gly Ala Thr Tyr Lys Asn Ser
20 25 30
Ala Phe Ser Trp Ala Arg Gln Ala Pro Gly Gln Gly Phe Gln Trp Met
35 40 45
Gly Gly Ile Ile Pro Leu Phe Gly Val Pro His Tyr Val Gln Met Phe
50 55 60
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Ala Val Tyr
65 70 75 80
Met Glu Leu Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu Glu Tyr Ser Gly Thr Val His Asn Phe Phe Gly Met Asp
100 105 110
Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 822
<211> 122
<212> PRT
<213> Homo sapiens
<400> 822
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ser Ala Ser Glu Phe Thr Leu Arg Ser His
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val
35 40 45
Ser Gly Ile Ser Thr Asp Gly Ser Gly Arg Phe Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Lys Leu Phe
65 70 75 80
Leu Gln Met Ser Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Val Arg Asp Trp Gly Ser Ser Thr His Tyr Asp Val Phe Asp Leu Trp
100 105 110
Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120
<210> 823
<211> 126
<212> PRT
<213> Homo sapiens
<400> 823
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Leu Ala Asp Tyr
20 25 30
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile Lys Pro Leu His Gly Ala Ala Gly Tyr Ser Gln His Phe
50 55 60
Arg Gly Arg Leu Ser Ile Thr Ala Asp Glu Ser Ala Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Thr Gly Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys
85 90 95
Ala Arg Asp Pro Ser Ile Leu Asn Thr Gly Asn His His Trp Tyr Asp
100 105 110
Leu Asp Leu Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120 125
<210> 824
<211> 126
<212> PRT
<213> Homo sapiens
<400> 824
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Leu Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Tyr Asn Ser
20 25 30
Ala Phe Ser Trp Leu Arg His Ala Pro Gly Gln Gly Pro Glu Trp Met
35 40 45
Gly Gly Ile Thr Pro Ser Leu Gly Arg Val Gly Tyr Ser Glu Arg Phe
50 55 60
Leu Ala Arg Leu Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Val Tyr
65 70 75 80
Met Glu Leu Thr Ser Leu Ala Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Ala Ser Ile Val Gly Thr Gly Asn His Leu Trp Tyr Gly
100 105 110
Leu Asp Phe Trp Gly His Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 825
<211> 123
<212> PRT
<213> Homo sapiens
<400> 825
Glu Val Gln Leu Val Glu Ser Gly Gly His Val Val Leu Pro Gly Lys
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Gly Ser Gly Phe Gly Phe Pro Leu Tyr
20 25 30
Ala Met Gln Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Leu Val Ser Tyr Asp Ser Ser Asn Ile Arg Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Gln Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Ala Met Tyr Tyr Cys
85 90 95
Ala Arg Asp Asn Ala Leu Gln Asp Gly Arg Pro Gly Tyr Phe Asp Ser
100 105 110
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 826
<211> 123
<212> PRT
<213> Homo sapiens
<400> 826
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asp Tyr
20 25 30
Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Tyr Ile Thr Gly Ser Gly Arg Thr Ile His Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly His Arg Phe Leu Glu Phe Pro Leu Asn Tyr Phe Asp Pro
100 105 110
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 827
<211> 123
<212> PRT
<213> Homo sapiens
<400> 827
Glu Val Gln Leu Leu Glu Ser Gly Gly His Val Val Leu Pro Gly Lys
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Gly Ser Gly Phe Gly Phe Pro Leu Tyr
20 25 30
Ala Met Gln Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Leu Val Ser Tyr Asp Ser Ser Asn Ile Arg Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Gln Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Ala Met Tyr Tyr Cys
85 90 95
Ala Arg Asp Asn Ala Leu Gln Asp Gly Arg Pro Gly Tyr Phe Asp Ser
100 105 110
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 828
<211> 130
<212> PRT
<213> Homo sapiens
<400> 828
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Phe
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Ile Ile Ser Tyr Asp Gly Ser His Lys Asn Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Val Asp Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Leu Leu Tyr Gly Ser Gly Ser Tyr Tyr Asn Phe Val Phe Phe Gly
100 105 110
Trp Lys Asp Gly Ser Asp Ala Trp Gly Pro Gly Thr Thr Val Thr Val
115 120 125
Ser Ser
130
<210> 829
<211> 129
<212> PRT
<213> Homo sapiens
<400> 829
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Met Phe Thr Asp Tyr
20 25 30
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met
35 40 45
Gly Gly Ile Leu Pro Ala Phe Ala Ala Ser Gly Ser Pro Gly Tyr Ala
50 55 60
Pro Ile Phe Arg Gly Arg Ala Thr Phe Ser Ala Asp Val Ser Thr Ser
65 70 75 80
Thr Ala Tyr Leu Glu Leu Thr Asn Leu Lys Pro Glu Asp Thr Ala Val
85 90 95
Tyr Tyr Cys Ala Arg Asp Pro Ser Ile Leu Asn Thr Gly Asn His His
100 105 110
Trp Tyr Asp Leu Asp Leu Trp Gly Gln Gly Thr Glu Val Thr Val Ser
115 120 125
Ser
<210> 830
<211> 126
<212> PRT
<213> Homo sapiens
<400> 830
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Leu Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Arg Val Ser Cys Lys Ala Ala Gly Gly Thr Leu Thr Asn Tyr
20 25 30
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Phe Glu Trp Met
35 40 45
Gly Gly Ile Met Pro Val Ser His Thr Ala Gly Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Phe Thr Ala Asp Glu Ser Ala Thr Thr Ala Tyr
65 70 75 80
Met Asp Leu Thr Ser Leu Arg Pro Glu Asp Thr Ala Ile Tyr Tyr Cys
85 90 95
Ala Arg Asp Pro Ser Ile His Tyr Thr Gly Asn His His Trp Tyr Asp
100 105 110
Leu Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120 125
<210> 831
<211> 126
<212> PRT
<213> Homo sapiens
<400> 831
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Leu Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Arg Val Ser Cys Lys Ala Ala Gly Gly Thr Leu Thr Asn Tyr
20 25 30
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Phe Glu Trp Met
35 40 45
Gly Gly Ile Met Pro Val Ser His Thr Ala Gly Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Phe Thr Ala Asp Glu Ser Ala Thr Thr Ala Tyr
65 70 75 80
Met Asp Leu Thr Ser Leu Arg Pro Glu Asp Thr Ala Ile Tyr Tyr Cys
85 90 95
Ala Arg Asp Pro Ser Ile His Tyr Thr Gly Asn His His Trp Tyr Asp
100 105 110
Leu Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120 125
<210> 832
<211> 129
<212> PRT
<213> Homo sapiens
<400> 832
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Met Arg Val Ser Cys Arg Val Ser Gly Gly Thr Phe Ile Thr His
20 25 30
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Pro Glu Trp Met
35 40 45
Gly Gly Ile Val Pro Leu Phe Gly Arg Ala Ser Tyr Ala Gln Pro Ser
50 55 60
Gln Thr Arg Val Gln Ile Thr Ala Asp Glu Ser Thr Ser Thr Val Tyr
65 70 75 80
Leu Glu Val Pro Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Val Arg Asp Ser Glu Pro Tyr Thr Ala Thr Arg Ser Gln Asn His Tyr
100 105 110
Trp Tyr Asp Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser
115 120 125
Ser
<210> 833
<211> 126
<212> PRT
<213> Homo sapiens
<400> 833
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Leu Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Arg Val Ser Cys Lys Ala Ala Gly Gly Thr Leu Thr Asn Tyr
20 25 30
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Phe Glu Trp Met
35 40 45
Gly Gly Ile Met Pro Val Ser His Thr Ala Gly Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Phe Thr Ala Asp Glu Ser Ala Thr Thr Ala Tyr
65 70 75 80
Met Asp Leu Thr Ser Leu Arg Pro Glu Asp Thr Ala Ile Tyr Tyr Cys
85 90 95
Ala Arg Asp Pro Ser Ile His Tyr Thr Gly Asn His His Trp Tyr Asp
100 105 110
Leu Asp Ile Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 834
<211> 126
<212> PRT
<213> Homo sapiens
<400> 834
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Leu Ser His Tyr
20 25 30
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile Met Pro Val Ser Gly Thr Val Gly Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Lys Phe Thr Ala Asp Glu Tyr Ala Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Thr Asn Leu Arg Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95
Ala Arg Asp Pro Ser Ile Val Asp Ser Gly Pro His His Trp Tyr Asp
100 105 110
Leu Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120 125
<210> 835
<211> 116
<212> PRT
<213> Homo sapiens
<400> 835
Gln Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Arg Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Asp Tyr
20 25 30
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Pro Glu Trp Met
35 40 45
Gly Trp Ile Asn Pro Asn Ser Gly Asp Thr Gly Tyr Pro Gln Lys Phe
50 55 60
Arg Gly Trp Val Thr Met Thr Arg Asp Thr Ser Val Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Lys Arg Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ser Gly Pro Asn Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 836
<211> 125
<212> PRT
<213> Homo sapiens
<400> 836
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Ser Asn Tyr
20 25 30
Asn Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Ser Gly Ser Ser Ser Tyr Ile Ser Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ala Asp Arg Asp Tyr Asp Phe Trp Ser Asp Pro Pro Leu Ile
100 105 110
Asp His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 837
<211> 120
<212> PRT
<213> Homo sapiens
<400> 837
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Thr Asp Asn
20 25 30
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Val Leu Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ala Val Gln
50 55 60
Gly Arg Phe Ser Ile Ser Arg Asp Asn Ser Lys Asn Ala Leu Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Gly Phe Gly Asn Gly Trp Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 838
<211> 129
<212> PRT
<213> Homo sapiens
<400> 838
Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Tyr Ile Thr Arg Ser Ser Asp Asn Ile Tyr Tyr Ala Glu Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu His Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Pro Gly Leu Glu Tyr Ser Gly Asn Tyr Phe Ser Tyr Tyr
100 105 110
Tyr Tyr Ala Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser
115 120 125
Ser
<210> 839
<211> 129
<212> PRT
<213> Homo sapiens
<400> 839
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Thr His
20 25 30
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly His Gly Pro Glu Trp Met
35 40 45
Gly Gly Ile Ile Pro Leu Phe Gly Thr Ser Glu Ser Ala Gln Arg Phe
50 55 60
Gln Ala Arg Val Arg Phe Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Val Arg Asp Ser Asp Pro Tyr Thr Ala Thr Ser Arg Asn Asn His Tyr
100 105 110
Trp Tyr Asp Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser
115 120 125
Ser
<210> 840
<211> 126
<212> PRT
<213> Homo sapiens
<400> 840
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Val Ser Gly Gly Arg Phe Ser Asp Tyr
20 25 30
Ala Ile Ser Trp Leu Arg Gln Ala Pro Val Lys Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile Ile Pro Arg Leu Asn Arg Lys Gly Tyr Ser Gln Asp Phe
50 55 60
Gln Gly Arg Leu Thr Phe Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Gly Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Pro Thr Phe Leu Asn Ser Gly Asn His Phe Trp Tyr Ala
100 105 110
Val Asp Ile Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 841
<211> 129
<212> PRT
<213> Homo sapiens
<400> 841
Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Arg Thr Pro Gly Ser
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Thr His
20 25 30
Ala Phe Ser Trp Val Arg Gln Ala Pro Gly Gln Arg Pro Glu Trp Met
35 40 45
Gly Gly Ile Ile Pro Ile Phe Gly Glu Ser Lys Asp Thr Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Phe Thr Ala Asp Glu Ser Thr Thr Thr Val Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Lys Ser Asp Asp Thr Ala Ile Tyr Tyr Cys
85 90 95
Val Arg Asp Ser Asp Pro Tyr Thr Ala Thr Tyr Arg Asn Asn His Tyr
100 105 110
Trp Tyr Ala Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser
115 120 125
Ser
<210> 842
<211> 120
<212> PRT
<213> Homo sapiens
<400> 842
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Lys Pro Gly Gly
1 5 10 15
Ser Leu Arg Val Ser Cys Val Gly Ser Gly Phe Thr Phe Ser Asp His
20 25 30
Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Ile Ile
35 40 45
Ser Tyr Ile Ser Thr Asp Gly Ser Tyr Ile Asn Asp Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Ile Asn Ser Arg Asp Asn Ala Lys Asn Ser Val Tyr
65 70 75 80
Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Met Gly Pro Ser Gly Ser Gly Ser Leu Asp Tyr Trp Gly Gln
100 105 110
Gly Ser Leu Val Thr Val Ser Ser
115 120
<210> 843
<211> 125
<212> PRT
<213> Homo sapiens
<400> 843
Glu Val Gln Leu Val Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln
1 5 10 15
Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Asn Thr Arg
20 25 30
Glu Leu Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu
35 40 45
Trp Leu Ala Leu Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Ser Pro Ser
50 55 60
Leu Lys Ser Arg Leu Ser Ile Thr Lys Asp Thr Ser Lys Asn Gln Val
65 70 75 80
Val Leu Thr Leu Thr Asn Met Asp Pro Gly Asp Thr Ala Thr Tyr Tyr
85 90 95
Cys Ala His Thr Ser Glu Leu Pro Pro Arg Arg Pro Tyr Ala Ala Phe
100 105 110
Asp Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 844
<211> 116
<212> PRT
<213> Homo sapiens
<400> 844
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Pro Phe Gly Arg Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu
35 40 45
Thr Leu Ile Ser Phe Asp Ser Ser Asn Ile Glu Tyr Ser Asp Ser Val
50 55 60
Gln Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Arg Asn Thr Leu Phe
65 70 75 80
Leu Gln Met Thr Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Phe Cys
85 90 95
Ala Arg Asp Leu Pro Pro Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 845
<211> 126
<212> PRT
<213> Homo sapiens
<400> 845
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Ala Val Asn Gly Gly Ser Phe Asn Asn Tyr
20 25 30
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Pro Glu Trp Ile
35 40 45
Gly Glu Val Val His Ser Gly Ser Thr Thr Tyr Asn Pro Ser Leu Lys
50 55 60
Ser Arg Val Thr Ile Ser Ile Asp Met Ser Lys Asn Gln Phe Ala Leu
65 70 75 80
Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Gly Phe Thr Phe Thr Tyr Ser Asp Phe Leu Thr Gly Gln Arg Thr
100 105 110
Phe Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 846
<211> 120
<212> PRT
<213> Homo sapiens
<400> 846
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Leu Ile Ser Tyr Asp Gly Asp Lys Lys Tyr Tyr Pro Asp Ser Val
50 55 60
Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu His
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Leu Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ser Tyr Gly Gly Ser Tyr Ser Thr Val Gly Tyr Trp Gly Gln
100 105 110
Gly Ala Leu Val Thr Val Ser Ser
115 120
<210> 847
<211> 120
<212> PRT
<213> Homo sapiens
<400> 847
Gln Val Gln Leu Val Gln Ser Gly Gly Asp Ser Val Asn Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Gly Ser Gly Phe Ser Val Arg Asp Val
20 25 30
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
35 40 45
Gly Arg Ile Lys Ser Glu Ala Asp Gly Gly Ser Ser Asp Tyr Arg Ala
50 55 60
Ser Leu Lys Asp Arg Phe Ser Ile Trp Arg Asp Ala Ser Lys Asn Thr
65 70 75 80
Leu Tyr Leu Gln Val Asn Gly Leu Gln Thr Glu Asp Thr Ala Ile Tyr
85 90 95
Phe Cys Ser Trp Asn Asp Val Gly Trp Ala Phe Thr Phe Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 848
<211> 124
<212> PRT
<213> Homo sapiens
<400> 848
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Ala Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Pro Phe Ser Ser Phe
20 25 30
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu
35 40 45
Gly Gly Ile Met Thr Val Phe Gly Pro Ala His Tyr Ala Gln Lys Ser
50 55 60
Arg Asp Arg Ile Ser Ile Thr Ala Asp Glu Ser Thr Ser Thr Ser Tyr
65 70 75 80
Leu Glu Leu Ser Ser Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ala Glu Glu Arg Ser Gly Thr Asn His Asn Tyr Tyr Gly Leu Asp
100 105 110
Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 849
<211> 124
<212> PRT
<213> Homo sapiens
<400> 849
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Phe Ser Gly Thr
20 25 30
Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ile Ile Tyr Ser Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Met Tyr Tyr Cys Ala
85 90 95
Arg Asp Arg Glu Met Ala Ile Ile Thr Glu Arg Ser Tyr Gly Leu Asp
100 105 110
Val Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120
<210> 850
<211> 125
<212> PRT
<213> Homo sapiens
<400> 850
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Gly Ala Ser Gly Phe Thr Phe Ser Asp Tyr
20 25 30
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Thr Ile Ser Gly Ser Gly Asp Lys Thr Tyr Tyr Ala Asp Ser Leu
50 55 60
Lys Gly Arg Phe Thr Asn Ser Arg Asp Asn Ser Lys Ser Thr Leu Tyr
65 70 75 80
Leu Gln Met Thr Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys
85 90 95
Ala Lys Asp Arg Tyr Cys Ser Gly Gly Ser Cys Phe Tyr Asp Ala Phe
100 105 110
Asp Ile Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 851
<211> 122
<212> PRT
<213> Homo sapiens
<400> 851
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Ala Asp Tyr
20 25 30
Pro Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Ser His Gly Arg Ser Gln Gly Tyr Ala Ala Ser Val
50 55 60
Lys Gly Arg Phe Thr Phe Ser Arg Asp Asn Ser Gln Ser Ser Leu Phe
65 70 75 80
Leu Gln Leu Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Phe Cys
85 90 95
Ala Arg Glu Ala Gln Ser Ser Gly Arg Ala Gly Cys Leu Asp Ala Trp
100 105 110
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 852
<211> 126
<212> PRT
<213> Homo sapiens
<400> 852
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Leu Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Arg Val Ser Cys Lys Ala Ala Gly Gly Thr Leu Thr Asn Tyr
20 25 30
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Phe Glu Trp Met
35 40 45
Gly Gly Ile Met Pro Val Ser His Thr Ala Gly Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Phe Thr Ala Asp Glu Ser Ala Thr Thr Ala Tyr
65 70 75 80
Met Asp Leu Thr Ser Leu Arg Pro Glu Asp Thr Ala Ile Tyr Tyr Cys
85 90 95
Ala Arg Asp Pro Ser Ile His Tyr Thr Gly Asn His His Trp Tyr Asp
100 105 110
Leu Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120 125
<210> 853
<211> 129
<212> PRT
<213> Homo sapiens
<400> 853
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Arg Glu Pro Gly Ser
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Thr Ser Gly Gly Thr Phe Ser Thr His
20 25 30
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Arg Pro Glu Trp Met
35 40 45
Gly Gly Ile Met Pro Ile Phe Gly Glu Ser Lys Asp Thr Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Phe Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Lys Ser Asp Asp Thr Ala Ile Tyr Tyr Cys
85 90 95
Val Arg Asp Ser Asp Pro Tyr Thr Ala Thr Val Arg Ser Asn His Tyr
100 105 110
Trp Tyr Ala Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser
115 120 125
Ser
<210> 854
<211> 126
<212> PRT
<213> Homo sapiens
<400> 854
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Val Ser Gly Gly Arg Phe Ser Asp Tyr
20 25 30
Ala Ile Ser Trp Leu Arg Gln Ala Pro Val Lys Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile Ile Pro Arg Leu Asn Arg Lys Gly Tyr Ser Gln Asp Phe
50 55 60
Gln Gly Arg Leu Thr Phe Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Gly Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Pro Thr Phe Leu Asn Ser Gly Asn His Phe Trp Tyr Ala
100 105 110
Val Asp Ile Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 855
<211> 127
<212> PRT
<213> Homo sapiens
<400> 855
Gln Val Gln Leu Gln Glu Ser Gly Arg Gly Leu Val Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Thr Ser Ser
20 25 30
Arg Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Arg Asn Leu Glu
35 40 45
Trp Ile Gly Ser Ile His Tyr Ser Gly Thr Thr Ser Tyr Asn Pro Ser
50 55 60
Leu Trp Ser Arg Val Ala Ile Ser Val Asp Thr Ala Gln Asn Gln Phe
65 70 75 80
Ser Leu Arg Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
85 90 95
Cys Ala Ala Pro Ala Pro Ser Asn His Glu Ser Trp Ser Gly Thr Asp
100 105 110
Trp Phe Asp Pro Trp Gly Gln Gly Ile Leu Val Thr Val Ser Ser
115 120 125
<210> 856
<211> 123
<212> PRT
<213> Homo sapiens
<400> 856
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Gly Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Ser Phe Ile Thr Tyr
20 25 30
Asp Ile Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Ile Ser Thr Lys Ser Gly Asp Thr Arg Tyr Ala Gln Asn Val
50 55 60
Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Asn Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Asn Leu Lys Ser Asp Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Arg Thr Thr Pro Arg Gly Trp Glu Gln Trp Pro Val Leu Glu Tyr
100 105 110
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 857
<211> 124
<212> PRT
<213> Homo sapiens
<400> 857
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Asn Phe Asn Ser Tyr
20 25 30
Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu
35 40 45
Ser Tyr Ile Ser Ser Arg Ser Ser Thr Ile Lys Tyr Ala Ser Ser Val
50 55 60
Gln Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Lys Ser Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Phe Cys
85 90 95
Ala Arg Glu Leu Asp Ser Glu Thr Tyr Tyr Asn Tyr Asn Ser Leu Asp
100 105 110
Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 858
<211> 128
<212> PRT
<213> Homo sapiens
<400> 858
Gln Val Gln Leu Val Glu Ser Gly Gly Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Leu Ser Ser Tyr
20 25 30
Pro Ile Ser Trp Val Arg Gln Ala Pro Gly His Gly Leu Glu Trp Met
35 40 45
Gly Trp Ile Asn Thr Tyr Asn Gly Arg Thr Asn Tyr Glu Gln Met Leu
50 55 60
Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Val Val Phe Arg His Gly Gln Tyr Asp Asp Ser Ser Gly Arg
100 105 110
Leu Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120 125
<210> 859
<211> 126
<212> PRT
<213> Homo sapiens
<400> 859
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Leu Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Arg Val Ser Cys Lys Ala Ala Gly Gly Thr Leu Thr Asn Tyr
20 25 30
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Phe Glu Trp Met
35 40 45
Gly Gly Ile Met Pro Val Ser His Thr Ala Gly Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Phe Thr Ala Asp Glu Ser Ala Thr Thr Ala Tyr
65 70 75 80
Met Asp Leu Thr Ser Leu Arg Pro Glu Asp Thr Ala Ile Tyr Tyr Cys
85 90 95
Ala Arg Asp Pro Ser Ile His Tyr Thr Gly Asn His His Trp Tyr Asp
100 105 110
Leu Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120 125
<210> 860
<211> 129
<212> PRT
<213> Homo sapiens
<400> 860
Glu Val Gln Leu Leu Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Thr Ser Gly Gly Thr Phe Ser Thr His
20 25 30
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Pro Glu Trp Met
35 40 45
Gly Gly Ile Ile Pro Leu Phe Gly Thr Ser Glu His Ala Gln Arg Phe
50 55 60
Gln Ala Arg Val Lys Phe Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Val Arg Asp Ser Asp Pro Tyr Thr Ala Thr Ser Arg Asn Asn His Tyr
100 105 110
Trp Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser
115 120 125
Ser
<210> 861
<211> 122
<212> PRT
<213> Homo sapiens
<400> 861
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Thr
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Met Phe Lys Asn Tyr
20 25 30
Ala Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Phe Asp Gly Ser Asp Ile Ser Tyr Thr Glu Ser Val
50 55 60
Gln Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Glu Asn Met Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys
85 90 95
Ala Arg Glu Pro Asp Gly Ile Gly Ala Ala Gly Ile Ser Gly Tyr Trp
100 105 110
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 862
<211> 123
<212> PRT
<213> Homo sapiens
<400> 862
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asp Phe
20 25 30
Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Tyr Ile Ser Gly Ser Gly Asp Thr Ile Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe
65 70 75 80
Leu Gln Met Ser Ser Leu Gly Ala Glu Asp Thr Ala Met Tyr Tyr Cys
85 90 95
Ala Arg Glu Met Ala Thr Ser Phe Gly Tyr Tyr Phe Val Leu Asp Val
100 105 110
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 863
<211> 124
<212> PRT
<213> Homo sapiens
<400> 863
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Ser Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Phe
20 25 30
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
35 40 45
Gly Glu Ile Asn His Ser Gly Ser Ala Asn Tyr Asn Pro Ser Leu Met
50 55 60
Ser Arg Val Thr Ile Ser Met Asp Thr Ser Lys Lys Gln Phe Ser Leu
65 70 75 80
Gln Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Gly Gln Glu Ser Pro Ile Val Gly Val Thr Gly Arg Trp Phe Asp
100 105 110
Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 864
<211> 121
<212> PRT
<213> Homo sapiens
<400> 864
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Phe Thr Phe Ser Thr Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Leu Ile Ser Tyr Asp Gly Ile Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Ala Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Val Asn Ser Leu Arg Ala Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Val Arg Pro Tyr Ser Gly Ser Tyr Thr Asn Trp Phe Asp Leu Trp Gly
100 105 110
Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 865
<211> 126
<212> PRT
<213> Homo sapiens
<400> 865
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Met Leu Ser Asp Tyr
20 25 30
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met
35 40 45
Gly Gly Ile Met Pro Ala Phe Gly Ser Pro Gly Tyr Ala Gln Ile Phe
50 55 60
Arg Gly Arg Ala Thr Ile Ser Ala Asp Val Ser Thr Ser Thr Ala Tyr
65 70 75 80
Leu Glu Leu Thr Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Pro Ser Ile Leu Asn Thr Gly Asn His His Trp Tyr Asp
100 105 110
Leu Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120 125
<210> 866
<211> 126
<212> PRT
<213> Homo sapiens
<400> 866
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Met Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Val Ser Gly Gly Arg Phe Ser Asp Tyr
20 25 30
Ala Ile Ser Trp Leu Arg Gln Ala Pro Leu Glu Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile Val Pro His Leu Asn Arg Lys Gly Tyr Ser Gln Lys Phe
50 55 60
Gln Asp Arg Leu Thr Phe Thr Ala Asp Asp Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Gly Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Pro Thr Phe Leu Asn Thr Gly Asn His Phe Trp Tyr Ala
100 105 110
Val Asp Ile Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 867
<211> 129
<212> PRT
<213> Homo sapiens
<400> 867
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Thr His
20 25 30
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly His Gly Pro Glu Trp Leu
35 40 45
Gly Gly Ile Leu Pro Leu Phe Gly Thr Ser Glu Ser Ala Gln Arg Phe
50 55 60
Gln Ala Arg Val Lys Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Val Arg Asp Ser Asp Pro Tyr Thr Ala Thr Ser Arg Asn Asn His Tyr
100 105 110
Trp Tyr Ala Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser
115 120 125
Ser
<210> 868
<211> 126
<212> PRT
<213> Homo sapiens
<400> 868
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Val Ser Gly Gly Thr Phe Ser Asn Tyr
20 25 30
Ala Ile Ser Trp Leu Arg Gln Ala Pro Gly Gln Gly Pro Glu Trp Met
35 40 45
Gly Gly Ile Ile Pro Ala Leu Ser Arg Val Gly Tyr Val Arg Lys Phe
50 55 60
Gln Ala Arg Leu Thr Ile Ser Ala Asp Glu Leu Thr Thr Thr Ala Tyr
65 70 75 80
Met Asp Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Pro Ser Phe Leu Asn Thr Gly Asn His Phe Trp Tyr Asp
100 105 110
Phe Asp Leu Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 869
<211> 126
<212> PRT
<213> Homo sapiens
<400> 869
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Phe
20 25 30
Tyr Trp Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
35 40 45
Gly Glu Ile Asn His Ser Gly Ser Ser Asn Tyr Asp Leu Ser Leu Lys
50 55 60
Ser Arg Val Thr Met Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
65 70 75 80
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Gly Met Ile Ser Pro Arg Ile Pro Arg Thr Thr Arg Gln Arg Trp
100 105 110
Phe Asp Thr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 870
<211> 127
<212> PRT
<213> Homo sapiens
<400> 870
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Gly Val Tyr Gly Gly Ser Phe Ser Gly Tyr
20 25 30
Phe Trp Ser Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Ile
35 40 45
Gly Glu Ile Asn His Ser Arg Ser Met Ser Tyr Asn Pro Ser Leu Lys
50 55 60
Ser Arg Ile Thr Met Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
65 70 75 80
Asn Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Phe Cys Ala
85 90 95
Arg Gly Lys Ala His Arg Asn Asp Phe Trp Ser Gly Tyr Tyr Pro His
100 105 110
Trp Phe Asp Pro Trp Gly Gln Gly Ile Leu Val Thr Val Ser Ser
115 120 125
<210> 871
<211> 129
<212> PRT
<213> Homo sapiens
<400> 871
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ile Ser Gly Asp Thr Phe Ser Thr Asn
20 25 30
Ala Ile Ser Trp Leu Arg Gln Ala Pro Gly Arg Glu Pro Glu Trp Met
35 40 45
Gly Gly Ile Val Pro Leu Val Gly Pro Ala Ser Tyr Ala Gln Arg Pro
50 55 60
Gln Gly Arg Leu Thr Ile Thr Ala Asp Glu Phe Thr Asn Thr Ala Tyr
65 70 75 80
Leu Glu Leu Asn Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys
85 90 95
Ala Arg Asp Ser Asp Pro Tyr Thr Ala Thr Arg Arg His Asn His Tyr
100 105 110
Trp Tyr Ala Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser
115 120 125
Ser
<210> 872
<211> 129
<212> PRT
<213> Homo sapiens
<400> 872
Glu Val Gln Leu Leu Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Asn Ser Gln
20 25 30
Tyr Trp Asn Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Ile
35 40 45
Gly Tyr Val Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys
50 55 60
Ser Arg Val Thr Met Ser Val Asp Thr Ser Lys Asn His Phe Ser Leu
65 70 75 80
Asn Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Gly Leu Val Val Arg Tyr Phe Asp Gly Phe Pro Ser Gly Pro Ile
100 105 110
Ile Gly Ala Phe Asp Ile Trp Asn Gln Gly Thr Thr Val Thr Val Ser
115 120 125
Ser
<210> 873
<211> 129
<212> PRT
<213> Homo sapiens
<400> 873
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Val Ser Gly Gly Thr Phe Ser Ser His
20 25 30
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Arg Pro Glu Trp Met
35 40 45
Gly Gly Ile Met Pro Ile Phe Gly Glu Ser Lys Asp Thr Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Phe Thr Val Asp Glu Ser Thr Asn Thr Ala Tyr
65 70 75 80
Met Glu Leu Thr Ser Leu Lys Ser Glu Asp Thr Ala Ile Tyr Tyr Cys
85 90 95
Val Arg Asp Pro Asp Pro Tyr Thr Ala Thr Val Arg His Asn His Tyr
100 105 110
Trp His Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser
115 120 125
Ser
<210> 874
<211> 129
<212> PRT
<213> Homo sapiens
<400> 874
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Phe
20 25 30
His Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
35 40 45
Gly Glu Val Asn His Ser Gly Ser Thr Lys Tyr Asn Pro Ser Leu Lys
50 55 60
Ser Arg Val Thr Val Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
65 70 75 80
Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr Cys Ala
85 90 95
Arg Gly Ser Leu Ser Arg Glu Tyr Asp Phe Leu Thr Ala Pro Gln Asn
100 105 110
Gly Pro Trp Phe Asp Ser Trp Gly Gln Gly Ala Leu Val Thr Val Ser
115 120 125
Ser
<210> 875
<211> 129
<212> PRT
<213> Homo sapiens
<400> 875
Glu Val Gln Leu Leu Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Asn
20 25 30
Asn Leu Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu
35 40 45
Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser
50 55 60
Leu Lys Ser Arg Val Ile Ile Pro Val Asp Thr Ser Lys Asp Gln Phe
65 70 75 80
Ser Leu Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
85 90 95
Cys Ala Arg His Ser Gln Lys Asp Ile Val Leu Ile Pro Ala Ala Gln
100 105 110
Ser Pro Ile Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
115 120 125
Ser
<210> 876
<211> 121
<212> PRT
<213> Homo sapiens
<400> 876
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Thr Phe Ser Arg Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val
35 40 45
Ser Ala Ile Asn Leu Asn Gly Asp Ser Thr Tyr Tyr Thr Asp Ser Val
50 55 60
Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe
65 70 75 80
Leu Gln Met Ser Asn Val Arg Pro Glu Asp Thr Ala Phe Tyr Tyr Cys
85 90 95
Val Lys Asp Gly Gly Tyr Tyr Asp Ser Ser Gly Pro Gly His Trp Gly
100 105 110
Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 877
<211> 122
<212> PRT
<213> Homo sapiens
<400> 877
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Asp Ser Gly Asn Ala Phe Ile Ala Asn
20 25 30
Pro Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu
35 40 45
Ala Leu Ile Ser Thr Asp Gly Asn Asn Arg His Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Phe Ser Arg Asp Asn Ser Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Tyr Cys
85 90 95
Ala Arg Glu Ser Arg Ser Ser Gly Arg Ala Gly Cys Phe Asp Ser Trp
100 105 110
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 878
<211> 121
<212> PRT
<213> Homo sapiens
<400> 878
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Thr
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Thr Gly Phe Thr Phe Thr Thr Tyr
20 25 30
Pro Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Met Asn Gln Tyr Tyr Ala Asp Phe Leu
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ala Tyr Gly Gly Asn Tyr Gln Asn His Phe Asp His Trp Gly
100 105 110
Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 879
<211> 132
<212> PRT
<213> Homo sapiens
<400> 879
Glu Val Gln Leu Val Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Arg Cys Ala Val Tyr Gly Gly Ser Phe Asn Gly Phe
20 25 30
Tyr Trp Thr Trp Ile Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Ala Glu Ile Asn His Ser Gly Thr Thr Asn Tyr Asn Pro Ser Leu Lys
50 55 60
Ser Arg Val Thr Ile Ser Ile Asp Thr Ser Lys Lys Gln Phe Ser Leu
65 70 75 80
Ser Leu Lys Ser Val Thr Ala Ala Asp Thr Ala Met Tyr Phe Cys Ala
85 90 95
Arg Gly Thr Ile Ser Pro Ile Val Gly Val Pro Thr Pro Val Val Pro
100 105 110
Arg Arg Gly Arg Ser Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val
115 120 125
Thr Val Ser Ser
130
<210> 880
<211> 129
<212> PRT
<213> Homo sapiens
<400> 880
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Thr His
20 25 30
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly His Gly Pro Glu Trp Leu
35 40 45
Gly Gly Ile Ile Pro Leu Phe Gly Thr Ser Glu Ser Ala Gln Arg Phe
50 55 60
Gln Ala Arg Val Lys Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Val Arg Asp Ser Asp Pro Tyr Thr Ala Thr Ser Arg Asn Asn His Tyr
100 105 110
Trp Tyr Ala Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser
115 120 125
Ser
<210> 881
<211> 129
<212> PRT
<213> Homo sapiens
<400> 881
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Arg Glu Pro Gly Ser
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Thr Ser Gly Gly Pro Phe Ser Thr His
20 25 30
Ala Phe Ser Trp Val Arg Gln Ala Pro Gly Gln Arg Pro Glu Trp Met
35 40 45
Gly Gly Ile Met Pro Val Phe Gly Glu Ser Lys Asp Thr Gln Lys Phe
50 55 60
Lys Gly Arg Val Thr Phe Thr Ala Asp Ala Ser Thr Thr Thr Thr Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Lys Ser Asp Asp Thr Ala Ile Tyr Tyr Cys
85 90 95
Val Arg Asp Ser Asp Pro Tyr Thr Ala Thr Ser Ser His Asn His Tyr
100 105 110
Trp Tyr Ala Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser
115 120 125
Ser
<210> 882
<211> 118
<212> PRT
<213> Homo sapiens
<400> 882
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr
20 25 30
Tyr Met Ile Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu
35 40 45
Ser Tyr Ile Ser His Thr Ala Ser Thr Ile Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe
65 70 75 80
Leu Gln Met Asn Ser Leu Thr Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Arg Gly Ser Gly Val Ile Asp Pro Trp Gly Gln Gly Thr
100 105 110
Leu Val Thr Val Ser Ser
115
<210> 883
<211> 121
<212> PRT
<213> Homo sapiens
<400> 883
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Thr Phe Ser Arg Phe
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val
35 40 45
Ser Ala Ile Asn Leu Asn Gly Asp Ser Thr Tyr Tyr Thr Asp Ser Val
50 55 60
Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Ser Ser Val Arg Pro Asp Asp Thr Ala Phe Tyr Tyr Cys
85 90 95
Val Lys Asp Gly Gly Tyr Tyr Asp Ser Ser Gly Pro Gly His Trp Gly
100 105 110
Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 884
<211> 128
<212> PRT
<213> Homo sapiens
<400> 884
Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala Ser Val Thr Ala Gly
20 25 30
Ser Ser Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu
35 40 45
Trp Ile Gly Tyr Met Phe Ser Ser Gly Asn Thr Lys Tyr Asn Pro Ser
50 55 60
Leu Lys Ser Arg Val Thr Ile Ser Ala Asp Thr Ser Lys Asn Gln Phe
65 70 75 80
Ser Leu Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Phe
85 90 95
Cys Ala Arg Val Gly Trp Val Arg Tyr Phe Asp Trp Ser Lys Pro Tyr
100 105 110
Tyr Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 885
<211> 128
<212> PRT
<213> Homo sapiens
<400> 885
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Ser
20 25 30
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Arg Ile Gly Gly Gly Gly Gly Arg Thr Lys Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Cys Asp Leu Val Arg Tyr Phe Asp Trp Leu Gly Glu Glu Asn
100 105 110
Asn Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 886
<211> 129
<212> PRT
<213> Homo sapiens
<400> 886
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Arg Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Thr His
20 25 30
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Arg Pro Glu Trp Met
35 40 45
Gly Gly Ile Met Pro Ile Phe Gly Glu Ser Lys Asp Thr Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Phe Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Lys Ser Asp Asp Thr Ala Ile Tyr Tyr Cys
85 90 95
Val Arg Asp Ser Asp Pro Tyr Thr Ala Thr Val Arg Asn Asn His Tyr
100 105 110
Trp Tyr Ala Leu Asp Val Trp Gly Pro Gly Thr Met Val Thr Val Ser
115 120 125
Ser
<210> 887
<211> 123
<212> PRT
<213> Homo sapiens
<400> 887
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ser Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Arg Thr Tyr
20 25 30
Cys Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Leu Val Cys Gly Asp Asn Ile Asp Tyr Tyr Pro Asp Ser Val Lys
50 55 60
Gly Arg Phe Ser Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Leu Leu
65 70 75 80
His Met Asp Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Ala Thr Pro Pro Gly Gly Gly Thr Gly Trp Pro Tyr Phe Asp Phe
100 105 110
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 888
<211> 123
<212> PRT
<213> Homo sapiens
<400> 888
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Met Arg Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Arg Tyr
20 25 30
Cys Phe Ser Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met
35 40 45
Gly Gly Ile Met Ser Ile Leu Gly Ala His Tyr Ala Gln Lys Phe Gln
50 55 60
Gly Arg Val Thr Phe Thr Ala Asp Glu Ser Thr Asn Thr Ala Tyr Met
65 70 75 80
Glu Leu Ile Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Glu Glu Pro Ser Gly Thr Tyr His Asn Tyr Tyr Gly Leu Asp Val
100 105 110
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 889
<211> 130
<212> PRT
<213> Homo sapiens
<400> 889
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly
1 5 10 15
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser
20 25 30
Asp Trp Cys Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Pro Glu Trp
35 40 45
Ile Ala Glu Ile Ser His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu
50 55 60
Lys Ser Arg Val Thr Met Ser Val Asp Arg Ser Lys Asn Gln Phe Ser
65 70 75 80
Leu Asn Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ala Arg Ile Arg Gly Ala Thr His Tyr Asp Phe Trp Ser Gly Phe
100 105 110
Trp Ala Gly Pro Phe Asp Ile Trp Gly Gln Gly Thr Thr Val Thr Val
115 120 125
Ser Ser
130
<210> 890
<211> 126
<212> PRT
<213> Homo sapiens
<400> 890
Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly
1 5 10 15
Thr Leu Ser Leu Thr Cys Gly Val Ser Gly Val Ser Ile Ser Ser Ser
20 25 30
Ser Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Arg Gly Leu Glu Trp
35 40 45
Ile Gly Glu Ile Ser Pro Ser Gly Ser Thr Ser Tyr Asn Pro Ser Phe
50 55 60
Arg Ser Arg Leu Thr Met Ser Val Asp Lys Ser Arg Asn Gln Leu Ser
65 70 75 80
Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Thr Gln Ser Asn Asp Phe Trp Ser Gly Tyr Tyr Thr Ala Ala
100 105 110
Phe Asp Leu Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120 125
<210> 891
<211> 129
<212> PRT
<213> Homo sapiens
<400> 891
Gln Val Gln Leu Val Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Phe
20 25 30
His Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
35 40 45
Gly Glu Ile Asn His Ser Gly Ser Thr Lys Tyr Asn Pro Ser Leu Lys
50 55 60
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
65 70 75 80
Arg Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr Cys Ala
85 90 95
Arg Gly Ser Leu Ser Arg Glu Tyr Asp Phe Leu Thr Ala Pro Gln Asn
100 105 110
Gly Pro Trp Phe Asp Ser Trp Gly Gln Gly Ala Leu Val Thr Val Ser
115 120 125
Ser
<210> 892
<211> 124
<212> PRT
<213> Homo sapiens
<400> 892
Glu Val Gln Leu Val Glu Ser Gly Pro Glu Leu Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Ser Phe Ser Asn Phe
20 25 30
Ala Val Ser Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met
35 40 45
Gly Gly Val Ile Pro Arg Phe Gly Arg Ser Glu Tyr Val Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Ile Thr Val Asp Glu Ala Ala Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys
85 90 95
Val Leu Asp Thr Thr Ser Ala Asn Pro His Asn Trp Tyr Gly Met Asp
100 105 110
Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 893
<211> 120
<212> PRT
<213> Homo sapiens
<400> 893
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Asn Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Val Gly Ser Gly Phe Thr Phe Ser Asp Tyr
20 25 30
Tyr Met Gly Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Val Ile
35 40 45
Ser Tyr Ile Ser Ser Thr Gly Ser Tyr Ile Arg Asp Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Asn Ser Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Gly Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Met Gly Pro Tyr Gly Ser Gly Ser Phe Asp Tyr Trp Gly Leu
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 894
<211> 123
<212> PRT
<213> Homo sapiens
<400> 894
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Val Ser Ser Ser
20 25 30
Asp Tyr His Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu
35 40 45
Trp Ile Gly Ser Ile Tyr Tyr Gly Gly Arg Ser His Phe Asn Pro Ser
50 55 60
Leu Lys Ser Arg Val Ala Ile Phe Val Asp Thr Ser Asn Asn Gln Phe
65 70 75 80
Ser Leu Arg Leu Asn Ser Val Thr Ala Ser Asp Thr Ala Val Tyr Phe
85 90 95
Cys Ala Gly Arg His Gln Glu Leu Leu Pro Met Gly Ser Phe Asp Met
100 105 110
Trp Ala Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 895
<211> 126
<212> PRT
<213> Homo sapiens
<400> 895
Pro Gly Pro Ala Cys Thr Val Trp Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Met Phe Ser Asp Tyr
20 25 30
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met
35 40 45
Gly Gly Ile Met Pro Gly Leu Gly Ser Pro Gly Tyr Ala Gln Ile Phe
50 55 60
Arg Gly Arg Ala Thr Ile Ser Ala Asp Val Ser Thr Ser Thr Ala Tyr
65 70 75 80
Leu Glu Leu Thr Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Pro Ser Ile Leu Asn Thr Gly Asn His His Trp Tyr Asp
100 105 110
Leu Asp Ile Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120 125
<210> 896
<211> 122
<212> PRT
<213> Homo sapiens
<400> 896
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Ser Ser Thr His
20 25 30
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile Ile Pro Ile Phe Gly Thr Thr Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys
85 90 95
Val Arg Asp Gly Ala Tyr Asp Ser Ser Gly Tyr Tyr Ser Thr Gln Trp
100 105 110
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 897
<211> 126
<212> PRT
<213> Homo sapiens
<400> 897
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Val Ser Gly Gly Arg Phe Ser Asp Tyr
20 25 30
Ala Ile Ser Trp Leu Arg Gln Ala Pro Val Lys Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile Ile Pro Arg Leu Asn Arg Lys Gly Tyr Ser Gln Asp Phe
50 55 60
Gln Gly Arg Leu Thr Phe Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Gly Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Pro Thr Phe Leu Asn Ser Gly Asn His Phe Trp Tyr Ala
100 105 110
Val Asp Ile Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 898
<211> 126
<212> PRT
<213> Homo sapiens
<400> 898
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Thr Val Ser Cys Lys Val Ser Gly Gly Arg Phe Ser Asp Tyr
20 25 30
Ala Ile Ser Trp Leu Arg Gln Ala Pro Val Glu Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile Ile Pro His Leu Asn Lys Lys Gly Tyr Ser Gln Lys Phe
50 55 60
Gln Asp Arg Ile Thr Phe Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Gly Leu Thr Ser Glu Asp Thr Ala Ile Tyr Tyr Cys
85 90 95
Ala Arg Asp Pro Thr Phe Leu Asn Thr Gly Asn His Phe Trp Tyr Ala
100 105 110
Val Asp Ile Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 899
<211> 127
<212> PRT
<213> Homo sapiens
<400> 899
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Leu Phe
20 25 30
His Val His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Ile Asn Pro His Asn Gly Asp Thr Thr Phe Ala Glu Arg Phe
50 55 60
Gln Gly Arg Val Ala Leu Thr Arg Asp Thr Ser Ile Asn Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Arg Leu Thr Ser Asp Asp Thr Ala Val Tyr Phe Cys
85 90 95
Ala Arg Asp Phe Gly Val Arg Tyr Asp Asp Ser Arg Gln Leu Met Lys
100 105 110
Tyr Cys Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 900
<211> 126
<212> PRT
<213> Homo sapiens
<400> 900
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Leu Ala Asp Tyr
20 25 30
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile Lys Pro Leu His Gly Ala Ala Gly Tyr Ser Gln Leu Phe
50 55 60
Arg Gly Arg Leu Ser Ile Thr Ala Asp Glu Ser Ala Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Thr Gly Leu Thr Ser Asp Asp Thr Ala Met Tyr Tyr Cys
85 90 95
Ala Arg Asp Pro Ser Ile Leu Asn Thr Gly Asn His His Trp Tyr Asp
100 105 110
Leu Asp Leu Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 901
<211> 124
<212> PRT
<213> Homo sapiens
<400> 901
Gln Val Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Ser Ile Ser Ser Tyr
20 25 30
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met
35 40 45
Gly Gly Val Leu Pro Met Met Gly Arg Glu Ser Pro Val Gln Lys Phe
50 55 60
Lys Asp Arg Val Thr Ile Ala Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Ser Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Val Val Asp Thr Thr Met Ala Asp Pro His Asn Trp Tyr Gly Leu Asp
100 105 110
Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 902
<211> 130
<212> PRT
<213> Homo sapiens
<400> 902
Gln Val Gln Leu Val Gln Ser Gly Pro Gly Leu Val Arg Pro Ser Gly
1 5 10 15
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Asp Ser Ile Ser Gly Asp
20 25 30
Tyr Trp Cys Thr Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp
35 40 45
Ile Gly Lys Ile Ser His Ser Gly Ser Ile Asn Tyr Asn Pro Ser Leu
50 55 60
Lys Ser Arg Ile Thr Met Ser Val Asp Lys Ser Lys Asn Gln Phe Ser
65 70 75 80
Leu Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Met Tyr Tyr Cys
85 90 95
Ala Arg Val Arg Val Gly Ala Ser His His Asn Phe Trp Ser Gly Tyr
100 105 110
Tyr Thr Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Thr Val Thr Val
115 120 125
Ser Ser
130
<210> 903
<211> 126
<212> PRT
<213> Homo sapiens
<400> 903
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Val Ser Gly Gly Thr Phe Ser Asn Tyr
20 25 30
Ala Ile Ser Trp Leu Arg Gln Ala Pro Gly Gln Gly Pro Glu Trp Met
35 40 45
Gly Gly Ile Ile Pro Ala Leu Ser Arg Val Gly Tyr Ala Arg Lys Phe
50 55 60
Gln Ala Arg Leu Thr Ile Ser Ala Asp Glu Leu Thr Thr Thr Ala Tyr
65 70 75 80
Met Asp Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Pro Ser Phe Leu Asn Thr Gly Asn His Phe Trp Tyr Asp
100 105 110
Phe Asp Met Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 904
<211> 122
<212> PRT
<213> Homo sapiens
<400> 904
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Ser Ser Thr His
20 25 30
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile Ile Pro Ile Phe Gly Thr Thr Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys
85 90 95
Val Arg Asp Gly Ala Tyr Asp Ser Ser Gly Tyr Tyr Ser Thr Gln Trp
100 105 110
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 905
<211> 123
<212> PRT
<213> Homo sapiens
<400> 905
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr
20 25 30
Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Ser Ser Ser Ser Tyr Met Tyr Tyr Ala Asp Ser Met Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Gln Asn Ser Leu Tyr Leu
65 70 75 80
Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Asp Phe Pro Gly Asp Thr Ala Val Ala Gly Thr Gly Phe Asn Tyr
100 105 110
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 906
<211> 128
<212> PRT
<213> Homo sapiens
<400> 906
Gln Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Ile Gly Asp Tyr
20 25 30
Ala Met Thr Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Cys Val
35 40 45
Ala Val Ile Arg Ser Arg Ala Phe Gly Gly Thr Thr Glu Tyr Ala Ala
50 55 60
Ser Val Lys Gly Arg Phe Ile Val Ser Arg Asp Asp Ser Asn Ser Val
65 70 75 80
Ala Phe Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
85 90 95
Tyr Cys Ser Arg Asp Leu Arg Arg Gly Tyr Tyr Asp Ser Asn Gly His
100 105 110
Gln Gln Phe Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 907
<211> 136
<212> PRT
<213> Homo sapiens
<400> 907
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr
20 25 30
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Tyr Ser Asp Gly Arg Asn Glu Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu His
65 70 75 80
Leu Gln Met Asn Ser Leu Gly Ala Ala Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Pro Gly Pro Ile Thr Phe Phe Asp Trp Ser Pro Asp Lys
100 105 110
Ser Arg Lys Ser Tyr Tyr Asp Tyr Asn Gly Met Asp Val Trp Gly Gln
115 120 125
Gly Thr Thr Val Thr Val Ser Ser
130 135
<210> 908
<211> 116
<212> PRT
<213> Homo sapiens
<400> 908
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Thr
1 5 10 15
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Thr Phe
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Leu Ile Ser Phe Asp Ser Thr Asn Ile Arg Tyr Ala Asn Ser Val
50 55 60
Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Val Asp Ser Leu Arg Ile Glu Asp Thr Gly Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Leu Pro Pro Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 909
<211> 129
<212> PRT
<213> Homo sapiens
<400> 909
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Arg Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Thr His
20 25 30
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Arg Pro Glu Trp Met
35 40 45
Gly Gly Ile Ile Pro Ile Phe Gly Glu Ser Lys Asp Thr Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Phe Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Ile Tyr Tyr Cys
85 90 95
Val Arg Asp Ser Asp Pro Tyr Thr Thr Thr Phe Ser His Asn His Tyr
100 105 110
Trp Tyr Ala Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser
115 120 125
Ser
<210> 910
<211> 125
<212> PRT
<213> Homo sapiens
<400> 910
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Val Ser Cys Ser Ala Ser Gly Phe Thr Phe Ser Ser Phe
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val
35 40 45
Ala Gly Ile Ser Asp Asn Gly His Thr Thr Met Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Leu Ser Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Phe Cys
85 90 95
Val Lys Asp Asn Val Ile Leu Pro Gly Ala Ile Val Arg Pro Gln Phe
100 105 110
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 911
<211> 126
<212> PRT
<213> Homo sapiens
<400> 911
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Val Ser Gly Gly Met Phe Ser Asp Tyr
20 25 30
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met
35 40 45
Gly Gly Ile Met Pro Gly Leu Gly Ser Pro Ala Tyr Ala Gln Ile Phe
50 55 60
Arg Gly Arg Val Thr Ile Ser Ala Asp Ile Ser Thr Ser Thr Ala Tyr
65 70 75 80
Leu Glu Val Thr Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Pro Ser Ile Leu Asn Thr Gly Asn His His Trp Tyr Asp
100 105 110
Leu Asp Met Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 912
<211> 125
<212> PRT
<213> Homo sapiens
<400> 912
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Leu Ala Pro Tyr
20 25 30
Gly Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Phe Leu Ser His Asp Gly Ser His Leu Gly Tyr Val Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr Cys
85 90 95
Ala Arg Asp Asn Val Val Gln Gln Asn Ala Asp Asn Val Gly Tyr Phe
100 105 110
Asp Phe Trp Gly Gln Gly Ser Leu Val Thr Val Ser Ser
115 120 125
<210> 913
<211> 126
<212> PRT
<213> Homo sapiens
<400> 913
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Met Phe Arg Asp Tyr
20 25 30
Ala Ile Ser Trp Leu Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met
35 40 45
Gly Gly Ile Met Pro Ala Phe Gly Ala Pro Gly Tyr Ala Gln Ile Phe
50 55 60
Arg Gly Arg Ala Thr Ile Ser Ala Asp Val Ser Thr Thr Thr Ala Tyr
65 70 75 80
Leu Glu Leu Thr Ser Leu Met Pro Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Pro Ser Ile Leu Asn Thr Gly Asn His His Trp Tyr Asp
100 105 110
Leu Asp Leu Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 914
<211> 129
<212> PRT
<213> Homo sapiens
<400> 914
Gln Val Thr Leu Lys Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Thr Ser Gly Gly Thr Phe Ser Thr His
20 25 30
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Pro Glu Trp Met
35 40 45
Gly Gly Ile Ile Pro Leu Phe Gly Thr Ser Gln His Ala Gln Arg Phe
50 55 60
Gln Ala Arg Val Lys Phe Thr Ala Asp Glu Ser Thr Asn Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Val Arg Asp Ser Asp Pro Tyr Thr Ala Thr Ser Arg Asn Asn His Tyr
100 105 110
Trp Tyr Gly Met Asp Val Trp Gly His Gly Thr Thr Val Thr Val Ser
115 120 125
Ser
<210> 915
<211> 126
<212> PRT
<213> Homo sapiens
<400> 915
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Met Phe Ser Asp Tyr
20 25 30
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met
35 40 45
Gly Gly Ile Met Pro Gly Leu Gly Ser Pro Ala Tyr Ala Gln Ser Phe
50 55 60
Gly Gly Arg Val Thr Ile Ser Ala Asp Ile Ser Thr Ser Thr Ala Tyr
65 70 75 80
Leu Glu Val Thr Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Pro Ser Ile Leu Asn Thr Gly Asn His His Trp Tyr Asp
100 105 110
Leu Asp Met Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120 125
<210> 916
<211> 126
<212> PRT
<213> Homo sapiens
<400> 916
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Ser Phe Gly Asp Tyr
20 25 30
Ala Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Gln Trp Val
35 40 45
Gly Leu Ile Lys Thr Arg Ala Tyr Gly Ala Ala Thr Asp Tyr Ala Ala
50 55 60
Ser Val Gln Gly Arg Phe Ile Ile Ser Arg Asp Asp Ser Lys Ser Ile
65 70 75 80
Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
85 90 95
Phe Cys Ala Arg Glu Gly Thr Ser Leu Gly Tyr Tyr Tyr Tyr Tyr Ala
100 105 110
Met Asp Val Trp Gly His Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 917
<211> 126
<212> PRT
<213> Homo sapiens
<400> 917
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Met Phe Ser Asp Tyr
20 25 30
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met
35 40 45
Gly Gly Ile Met Pro Gly Leu Gly Ser Pro Ala Tyr Ala Gln Ile Phe
50 55 60
Arg Gly Arg Val Thr Ile Ser Ala Asp Ile Ser Thr Ser Thr Ala Tyr
65 70 75 80
Leu Glu Val Thr Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Pro Ser Ile Leu Asn Thr Gly Asn His His Trp Tyr Asp
100 105 110
Leu Asp Met Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 918
<211> 122
<212> PRT
<213> Homo sapiens
<400> 918
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Leu Thr Ser Gly Phe Ser Phe Ser Ser Tyr
20 25 30
Trp Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Asn Ile Glu Pro Asp Gly Asn Glu Glu Tyr Tyr Val Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Pro Ile Arg His Phe Gly Leu Asp Ala Phe Asp Ile Trp
100 105 110
Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 919
<211> 129
<212> PRT
<213> Homo sapiens
<400> 919
Gln Val Gln Leu Val Gln Ser Gly Asp Glu Met Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Asp Thr Phe Ser Thr His
20 25 30
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Pro Glu Trp Met
35 40 45
Gly Gly Ile Ile Pro Leu Phe Gly Thr Ala Ser Tyr Ala Gln Thr Ser
50 55 60
Gln Ser Arg Val Lys Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Val Arg Asp Ser Asp Pro Tyr Thr Ala Thr Ser Arg Asn Asn His Tyr
100 105 110
Trp Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser
115 120 125
Ser
<210> 920
<211> 126
<212> PRT
<213> Homo sapiens
<400> 920
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Met Phe Ser Asp Tyr
20 25 30
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met
35 40 45
Gly Gly Ile Met Pro Gly Leu Gly Ser Pro Ala Tyr Ala Gln Ser Phe
50 55 60
Gly Gly Arg Val Thr Ile Ser Ala Asp Ile Ser Thr Ser Thr Ala Tyr
65 70 75 80
Leu Glu Val Thr Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Pro Ser Ile Leu Asn Thr Gly Asn His His Trp Tyr Asp
100 105 110
Leu Asp Met Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120 125
<210> 921
<211> 122
<212> PRT
<213> Homo sapiens
<400> 921
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Thr Phe Ser Asn Tyr
20 25 30
Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Arg Pro Glu Tyr Val
35 40 45
Ser Gly Ile Ser Ser Asn Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Glu Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Lys Ser Leu Tyr
65 70 75 80
Leu Gln Met Ser Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Val Lys Asp Leu Gly Ala Thr Val Thr Tyr Asp Val Phe Asp Val Trp
100 105 110
Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120
<210> 922
<211> 120
<212> PRT
<213> Homo sapiens
<400> 922
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Gly His Asp Gly Gly Thr Thr His Tyr Ala Asp Ser Val Lys Gly
50 55 60
Arg Phe Thr Ile Ser Arg Asp Asp Ser Met Asn Thr Leu Ser Leu Gln
65 70 75 80
Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys
85 90 95
Glu Arg Asp Leu Pro Gly Arg Gly Gly Tyr Phe Asp His Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 923
<211> 129
<212> PRT
<213> Homo sapiens
<400> 923
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Arg Gly Phe
20 25 30
Tyr Trp Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
35 40 45
Gly Glu Val Ser His Ser Gly Glu Thr Asn Tyr Asn Pro Ser Leu Lys
50 55 60
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
65 70 75 80
Asn Leu Ile Ser Val Thr Ala Ala Asp Thr Ser Val Tyr Tyr Cys Ala
85 90 95
Arg Gly Tyr Thr Ala Pro Ile Ile Arg Glu Val Pro Ile Thr Phe Arg
100 105 110
Pro Arg Trp Phe Asp Pro Trp Gly Gln Gly Thr Pro Val Thr Val Ser
115 120 125
Ser
<210> 924
<211> 120
<212> PRT
<213> Homo sapiens
<400> 924
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Asn Pro Gly Gly
1 5 10 15
Ser Met Arg Leu Ser Cys Ala Gly Ser Gly Phe Thr Phe Ser Asp His
20 25 30
Tyr Met Gly Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Val Ile
35 40 45
Ser Tyr Ile Ser Ser Ser Gly Ser Phe Ile Arg Asp Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Met Gly Pro Tyr Gly Ser Gly Thr Phe Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 925
<211> 123
<212> PRT
<213> Homo sapiens
<400> 925
Gln Val Gln Leu Val Gln Ser Gly Gly Asn Val Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Val Gly Ser Glu Phe Ser Ile Thr Phe Phe
20 25 30
Ala Met Gln Trp Val Arg Arg Thr Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Leu Val Ser His Asp Gly Ser Asn Ile Arg Tyr Ser Asp Ser Val
50 55 60
Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Leu Asp Ser Leu Thr Pro Glu Asp Thr Gly Ile Tyr Tyr Cys
85 90 95
Ala Arg Asp His Ala Leu Gln Asn Gly Arg Pro Gly Tyr Phe Asp Ser
100 105 110
Trp Gly Gln Gly Ser Gln Val Thr Val Ser Ser
115 120
<210> 926
<211> 121
<212> PRT
<213> Homo sapiens
<400> 926
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Thr Phe Asn Thr Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Tyr Val
35 40 45
Ser Ser Ile Thr Arg Asp Gly Ala Gly Lys Phe Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Gln Gln Met Ser Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Val Arg Glu Gly Gln Gln Trp Leu Gly Leu Tyr Phe Asp His Trp Gly
100 105 110
Gln Gly Ala Leu Val Thr Val Ser Ser
115 120
<210> 927
<211> 125
<212> PRT
<213> Homo sapiens
<400> 927
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Arg Ala Ser Gly Tyr Thr Phe Ser Gly Tyr
20 25 30
Asp Ile Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Met Asn Pro Asn Ser Gly Asp Thr Gly Tyr Ala His Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Arg Asn Ser Ser Ile Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Phe Cys
85 90 95
Ala Arg Glu Lys Lys Ser Phe Gly Pro Gln Tyr Tyr Tyr Gly Ser Gly
100 105 110
Glu Asp Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 928
<211> 127
<212> PRT
<213> Homo sapiens
<400> 928
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Met Lys Lys Pro Gly Glu
1 5 10 15
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Pro Asn Tyr
20 25 30
Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
35 40 45
Ala Ile Met Trp Pro Ser Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe
50 55 60
Gln Gly Gln Val Thr Ile Ser Ala Asp Thr Ser Thr Ser Thr Val Tyr
65 70 75 80
Leu Gln Trp Gly Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
85 90 95
Val Arg Gln Arg Tyr Cys Ser Gly Gly Ser Cys Phe Leu Phe Glu Asp
100 105 110
Ala Phe Glu Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120 125
<210> 929
<211> 117
<212> PRT
<213> Homo sapiens
<400> 929
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Lys Asn Glu
20 25 30
Pro Met Asn Trp Ile Arg Gln Phe Pro Gly Lys Gly Leu Glu Trp Ile
35 40 45
Ser Asn Ile Arg Asp Asn Gly Asn Asp Val Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Asp Asp Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Val Arg Asp Thr Asp Trp Ala Phe Asp Ser Trp Gly Gln Gly Thr Leu
100 105 110
Val Thr Val Ser Ser
115
<210> 930
<211> 125
<212> PRT
<213> Homo sapiens
<400> 930
Glu Val Gln Leu Val Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln
1 5 10 15
Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Arg
20 25 30
Arg Gln Gly Val Gly Trp Leu Arg Arg Pro Pro Gly Lys Ala Leu Glu
35 40 45
Trp Leu Ala Leu Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Ser Pro Ser
50 55 60
Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn His Val
65 70 75 80
Val Leu Ser Leu Thr Asn Val Gly Pro Ala Asp Thr Ala Thr Tyr Tyr
85 90 95
Cys Ala His Thr Ser Glu Leu Pro Pro Arg Arg Pro Tyr Ala Ala Phe
100 105 110
Asp Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 931
<211> 115
<212> PRT
<213> Homo sapiens
<400> 931
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Phe Ser Thr Asp
20 25 30
Ala Met Asn Trp Val Arg Gln Ala Pro Gly Glu Gly Leu Glu Trp Val
35 40 45
Ser Thr Ile Ser Asp Ser Gly Arg Asp Thr Tyr Tyr Ala Ala Ser Val
50 55 60
Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Asn Thr Asn Phe Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr
100 105 110
Val Ser Ser
115
<210> 932
<211> 127
<212> PRT
<213> Homo sapiens
<400> 932
Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Leu Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ser Pro Ile Ala Ser Asn
20 25 30
Tyr Trp Ser Trp Val Arg Gln Pro Ala Gly Lys Gly Leu Glu Trp Ile
35 40 45
Gly Arg Ile Asp Thr Ser Pro Thr Thr Asp Tyr Asn Pro Ser Leu Lys
50 55 60
Ser Arg Val Ile Met Ser Val Asp Thr Ser Thr Ser Gln Phe Ser Leu
65 70 75 80
Lys Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Thr
85 90 95
Arg Ser Phe Ile Ser Phe Asp Ser Ser Gly His Pro Tyr Tyr Tyr Tyr
100 105 110
Ala Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 933
<211> 118
<212> PRT
<213> Homo sapiens
<400> 933
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Arg Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Leu Ser Cys Arg Ala Ser Gly Gly Thr Phe His Thr Tyr
20 25 30
Thr Val Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu
35 40 45
Gly Gly Ile Ile Pro Ile Phe Gly Thr Pro Thr Tyr Ala Gln Arg Phe
50 55 60
Gln Gly Lys Val Ser Ile Thr Ala Asp Ser Ser Thr Asn Thr Val Phe
65 70 75 80
Met Glu Leu Thr Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Thr Arg Glu Thr Gly Thr Asp Glu Phe Asp Phe Trp Gly Gln Gly Ala
100 105 110
Leu Val Thr Val Ser Ser
115
<210> 934
<211> 127
<212> PRT
<213> Homo sapiens
<400> 934
Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly
1 5 10 15
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Ala Ser Val Ser Ser Asp
20 25 30
His Trp Trp Ser Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp
35 40 45
Ile Gly Glu Val Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu
50 55 60
Lys Ser Arg Val Thr Ile Ser Leu Asp Gln Ser Asn Asn Gln Phe Ser
65 70 75 80
Leu Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr Cys
85 90 95
Ala Thr Met Trp Gly Gly Leu Cys Thr Ala Ser Asn Cys Tyr Gly Asn
100 105 110
Pro Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 935
<211> 127
<212> PRT
<213> Homo sapiens
<400> 935
Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly
1 5 10 15
Thr Leu Ser Leu Thr Cys Ala Val Thr Gly Ala Ser Val Ser Ser Asp
20 25 30
His Trp Trp Ser Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp
35 40 45
Ile Gly Glu Val Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu
50 55 60
Lys Ser Arg Val Thr Ile Ser Leu Asp Gln Ser Asn Asn Gln Phe Ser
65 70 75 80
Leu Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr Cys
85 90 95
Ala Thr Met Trp Gly Gly Leu Cys Thr Ala Ser Asn Cys Tyr Gly Asn
100 105 110
Pro Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 936
<211> 127
<212> PRT
<213> Homo sapiens
<400> 936
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly
1 5 10 15
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Ala Ser Val Ser Ser Asp
20 25 30
His Trp Trp Ser Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp
35 40 45
Ile Gly Glu Val Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu
50 55 60
Lys Ser Arg Val Thr Ile Ser Leu Asp Gln Ser Asn Asn Gln Phe Ser
65 70 75 80
Leu Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr Cys
85 90 95
Ala Thr Met Trp Gly Gly Leu Cys Thr Ala Ser Asn Cys Tyr Gly Asn
100 105 110
Pro Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 937
<211> 118
<212> PRT
<213> Homo sapiens
<400> 937
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Ser Phe Ser Asp Phe
20 25 30
Val Met His Trp Val Arg Gln Val Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Arg Ile Ser His Asp Gly Ser Ile Thr Ser Tyr Val Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Gly Lys Lys Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Pro Arg Thr Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Leu Ala Trp Thr Phe Phe Asp Tyr Trp Gly His Gly Thr
100 105 110
Leu Val Thr Val Ser Ser
115
<210> 938
<211> 123
<212> PRT
<213> Homo sapiens
<400> 938
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Ser Arg Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Ala Ser Arg Asn
20 25 30
Cys Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ile Ile Cys Gly Asp Glu Ile Thr Tyr Ile Arg Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu His Leu
65 70 75 80
Glu Met Asn Ser Leu Arg Ala Asp Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Ala Thr Pro Pro Gly Gly Thr Thr Gly Trp Pro Tyr Ile Asp Leu
100 105 110
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 939
<211> 115
<212> PRT
<213> Homo sapiens
<400> 939
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Phe Ser Thr Asp
20 25 30
Ala Met Asn Trp Val Arg Gln Ala Pro Gly Glu Gly Leu Glu Trp Val
35 40 45
Ser Thr Ile Ser Asp Thr Gly Arg Asp Thr Tyr Tyr Ala Ala Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Asn Thr Asn Phe Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr
100 105 110
Val Ser Ser
115
<210> 940
<211> 120
<212> PRT
<213> Homo sapiens
<400> 940
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Leu Asp Asp Tyr
20 25 30
Ala Val His Trp Val Arg Leu Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Gly Ile Thr Trp Asn Ser Gly Tyr Leu Gly Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Lys Leu Gly Thr Asp His Pro Ile Gly Val Asp Val Trp Gly Gln
100 105 110
Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 941
<211> 121
<212> PRT
<213> Homo sapiens
<400> 941
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Thr Phe Asn Thr Tyr
20 25 30
Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val
35 40 45
Ser Ala Ile Ser Ser Asn Gly Val Val Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Val Lys Ala Leu Tyr Ser Ser Ser Trp Cys Pro Phe Asp Tyr Trp Gly
100 105 110
Gln Gly Ala Leu Val Thr Val Ser Ser
115 120
<210> 942
<211> 124
<212> PRT
<213> Homo sapiens
<400> 942
Gln Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Asn Phe Asn Ser Tyr
20 25 30
Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu
35 40 45
Ser Tyr Ile Ser Ser Arg Ser Ser Thr Ile Lys Tyr Ala Ser Ser Val
50 55 60
Gln Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Lys Ser Val Phe
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu Leu Asp Ser Glu Thr Tyr Tyr Asn Tyr Asn Ser Leu Asp
100 105 110
Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 943
<211> 123
<212> PRT
<213> Homo sapiens
<400> 943
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Arg Gly Ser Ile Ser Ser Ser
20 25 30
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
35 40 45
Gly Phe Met Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys
50 55 60
Ser Arg Val Thr Ile Ser Leu Asp Thr Ser Lys Asn Gln Phe Ser Leu
65 70 75 80
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Lys Ala Gln Gly Ile Tyr Tyr Arg Gly Trp Ser Tyr Trp Phe Asp Pro
100 105 110
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 944
<211> 131
<212> PRT
<213> Homo sapiens
<400> 944
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Arg Asn Asn
20 25 30
Tyr Ile Asn Trp Ile Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Ile Ile Asn Pro Ser Ala Gly Thr Ser Thr Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Asn Thr Val Tyr
65 70 75 80
Met Glu Ile Thr Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Phe Cys
85 90 95
Ala Arg Glu Ala Arg Arg Gln Val Thr Gln Trp Phe Gly Glu Phe Trp
100 105 110
Gly Pro Tyr Asn Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr
115 120 125
Val Ser Ser
130
<210> 945
<211> 124
<212> PRT
<213> Homo sapiens
<400> 945
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Gly Val Tyr Gly Val Ser Phe Ser Asp Tyr
20 25 30
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
35 40 45
Gly Glu Ile Asn His Ser Gly Ile Thr Asn Tyr Asn Pro Ser Leu Lys
50 55 60
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
65 70 75 80
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Gly Leu Ile Ser Tyr Thr Leu Trp Leu Arg Glu Ser Tyr Phe Asp
100 105 110
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 946
<211> 126
<212> PRT
<213> Homo sapiens
<400> 946
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Ser Leu Arg Asp Tyr
20 25 30
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Pro Glu Trp Met
35 40 45
Gly Gly Ile Met Pro Ile Phe Gly Thr Ala Gly Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Lys Phe Thr Ala Asp Glu Ser Ala Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu Thr Gly Leu Arg Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95
Ala Arg Asp Pro Ser Ile Leu Asn Thr Gly Asn His His Trp Tyr Asp
100 105 110
Leu Asp Ile Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 947
<211> 118
<212> PRT
<213> Homo sapiens
<400> 947
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Asp
20 25 30
Gly Phe Val Trp Val Arg Gln Ala Pro Gly Gln Val Pro Glu Trp Met
35 40 45
Gly Trp Ile Ser Val His Thr Gly Asp Thr Ile Tyr Ala Gln Arg Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Arg Thr Ser Tyr
65 70 75 80
Met Glu Leu Met Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Tyr Gly Asp Gly Pro Pro Asp His Trp Gly Gln Gly Thr
100 105 110
Leu Val Thr Val Ser Ser
115
<210> 948
<211> 124
<212> PRT
<213> Homo sapiens
<400> 948
Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Arg Val Ser Cys Lys Val Ser Gly Gly Pro Phe Ser Ser Tyr
20 25 30
Gly Val Ser Trp Ala Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Met
35 40 45
Gly Gly Val Leu Pro Ile Phe Gly Thr Val Gly Tyr Val His Lys Phe
50 55 60
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Val Tyr
65 70 75 80
Met Ala Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Val Leu Asp Thr Thr Met Ser His Pro His Asn Trp Tyr Gly Met Asp
100 105 110
Val Trp Gly His Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 949
<211> 125
<212> PRT
<213> Homo sapiens
<400> 949
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Met Lys Leu Ser Cys Lys Ala Ser Gly Ile Asn Phe Arg Ser Tyr
20 25 30
Ser Phe Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Val Ile Pro Tyr Phe Pro Thr Ala Asn Tyr Ala Glu Lys Phe
50 55 60
Arg Gly Arg Val Thr Ala Thr Ala Asp Glu Ser Thr Gly Thr Val Tyr
65 70 75 80
Leu Glu Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ser Glu Tyr Phe Asp Gly Arg Ser Tyr His Ser Phe Cys Gly Leu
100 105 110
Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 950
<211> 126
<212> PRT
<213> Homo sapiens
<400> 950
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Leu Ser Asp Tyr
20 25 30
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile Met Pro Val Phe Gly Ser Pro Gly Tyr Ala Glu Ile Phe
50 55 60
Gln Gly Arg Leu Thr Ile Thr Ala Asp Glu Ser Arg Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Thr Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Pro Ser Ile Leu Asn Thr Gly Pro His His Trp Tyr Asp
100 105 110
Leu Asp Ile Trp Gly Pro Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 951
<211> 129
<212> PRT
<213> Homo sapiens
<400> 951
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Met Arg Val Ser Cys Arg Val Ser Gly Gly Thr Phe Ile Thr His
20 25 30
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Pro Glu Trp Met
35 40 45
Gly Gly Ile Val Pro Leu Phe Gly Arg Ala Ser Tyr Ala Gln Pro Ser
50 55 60
Gln Thr Arg Val Gln Ile Thr Ala Asp Glu Ser Thr Ser Thr Val Tyr
65 70 75 80
Leu Glu Val Pro Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Val Arg Asp Ser Glu Pro Tyr Thr Ala Thr Arg Ser Gln Asn His Tyr
100 105 110
Trp Tyr Asp Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser
115 120 125
Ser
<210> 952
<211> 125
<212> PRT
<213> Homo sapiens
<400> 952
Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Ala
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Asn Asn Tyr
20 25 30
Tyr Trp Thr Trp Val Arg Gln Ser Ala Gly Lys Gly Leu Glu Trp Ile
35 40 45
Gly Arg Ile Asn Thr Ser Gly Ser Thr Asn Tyr Asn Ala Ser Leu Lys
50 55 60
Ser Arg Val Thr Met Ser Ile Asp Thr Ser Lys Asn Glu Phe Ser Leu
65 70 75 80
Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Glu Phe Gly Val Arg Phe Leu Asp Arg Ser Leu Phe Gly Ala Met
100 105 110
Asp Val Trp Gly His Gly Ala Thr Val Thr Val Ser Ser
115 120 125
<210> 953
<211> 119
<212> PRT
<213> Homo sapiens
<400> 953
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ala Phe
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Thr Ile Ile Ser Tyr Asp Gly Ser Asn Glu Tyr Tyr Ala Asp Ser Val
50 55 60
Gln Gly Arg Phe Ser Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe
65 70 75 80
Leu Gln Met Ser Ser Leu Arg Thr Glu Asp Thr Ala Ile Tyr Tyr Cys
85 90 95
Ala Arg Ala Gly Gly Tyr Leu Ser Ala Phe Asp Ile Trp Gly Gln Gly
100 105 110
Thr Thr Val Thr Val Ser Ser
115
<210> 954
<211> 126
<212> PRT
<213> Homo sapiens
<400> 954
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Val Ser Gly Gly Thr Phe Ser Asn Tyr
20 25 30
Ala Ile Ser Trp Leu Arg Gln Ala Pro Gly Gln Gly Pro Glu Trp Met
35 40 45
Gly Gly Ile Ile Pro Ala Leu Ser Lys Val Gly Tyr Ala Gly Lys Phe
50 55 60
Gln Ala Arg Leu Thr Phe Ser Ala Asp Glu Leu Lys Thr Thr Val Tyr
65 70 75 80
Met Asp Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Pro Ser Phe Leu Asn Ala Gly Asn His Phe Tyr Tyr Asp
100 105 110
Phe Asp Val Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120 125
<210> 955
<211> 125
<212> PRT
<213> Homo sapiens
<400> 955
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly
1 5 10 15
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Thr Ser Arg
20 25 30
Asp Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp
35 40 45
Ile Gly Glu Val Tyr His Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu
50 55 60
Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Glu Phe Ser
65 70 75 80
Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ala Gly Asn Ile Val Val Met Pro Ala Ala Gln Tyr Tyr Phe
100 105 110
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 956
<211> 127
<212> PRT
<213> Homo sapiens
<400> 956
Glu Val Gln Leu Val Glu Ser Gly Gly Ser Val Val Gln Pro Gly Thr
1 5 10 15
Ser Leu Lys Leu Ser Cys Ala Gly Ser Ala Gly Leu Thr Ile Thr Arg
20 25 30
Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp
35 40 45
Val Ala Leu Val Ser His Asp Gly Ile His Ile Gly Tyr Ser Asp Ser
50 55 60
Val Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Arg Asn Thr Leu
65 70 75 80
Tyr Leu Gln Met Asp Gly Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr
85 90 95
Cys Val Arg Asp Asp Val Leu Gln His Ser Arg Pro Ser Gly Pro Gly
100 105 110
Tyr Phe Val Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 957
<211> 125
<212> PRT
<213> Homo sapiens
<400> 957
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Met Asn His Tyr
20 25 30
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Gly Ile
35 40 45
Gly Tyr Thr Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys
50 55 60
Ser Arg Val Thr Ile Ser Val Asp Ala Ser Lys Asn Gln Phe Ser Leu
65 70 75 80
Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Arg Gly Ser Gln Ile Asp Leu Arg Gly Gly Leu Gly Ala Thr Phe Phe
100 105 110
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 958
<211> 129
<212> PRT
<213> Homo sapiens
<400> 958
Gln Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ile Ser Gly Asp Thr Phe Ser Thr Asn
20 25 30
Ala Ile Ser Trp Leu Arg Gln Ala Pro Gly Arg Glu Pro Glu Trp Met
35 40 45
Gly Gly Ile Val Pro Leu Val Gly Pro Ala Ser Tyr Ala Gln Arg Pro
50 55 60
Gln Gly Arg Leu Thr Ile Thr Ala Asp Glu Phe Thr Asn Thr Ala Tyr
65 70 75 80
Leu Glu Leu Asn Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys
85 90 95
Ala Arg Asp Ser Asp Pro Tyr Thr Ala Thr Arg Arg His Asn His Tyr
100 105 110
Trp Tyr Ala Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser
115 120 125
Ser
<210> 959
<211> 117
<212> PRT
<213> Homo sapiens
<400> 959
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Lys Asn Glu
20 25 30
Pro Met Asn Trp Ile Arg Gln Phe Pro Gly Lys Gly Leu Glu Trp Ile
35 40 45
Ser Asn Ile Arg Asp Asn Gly Asn Asp Val Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Asp Asp Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Val Arg Asp Thr Asp Trp Ala Phe Asp Ser Trp Gly Gln Gly Thr Leu
100 105 110
Val Thr Val Ser Ser
115
<210> 960
<211> 124
<212> PRT
<213> Homo sapiens
<400> 960
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Ser Tyr
20 25 30
Asp Ile Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Met Ser Pro Asn Thr Gly Asp Thr Gly Tyr Ala His Lys Phe
50 55 60
Gln Gly Arg Val Arg Met Thr Ser Asn Thr Ser Ile Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Asn Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Arg Gly Asn Asn Phe Gly Tyr Tyr Tyr Tyr Tyr Thr Val Asp
100 105 110
Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 961
<211> 127
<212> PRT
<213> Homo sapiens
<400> 961
Gln Val Gln Leu Val Gln Ser Gly Ala Asp Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu
35 40 45
Gly Val Ile His Pro Ser Gly Gly Ser Thr Thr Phe Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Val Leu Ala Gly Ser Ser His Glu Trp Gln Leu Thr His Asp
100 105 110
Ala Phe Asp Ile Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 962
<211> 127
<212> PRT
<213> Homo sapiens
<400> 962
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Gly Ile Asp Gly Gly Gly Gly Ser Ser Tyr Tyr Ala Asp Ser Val
50 55 60
Arg Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Asn Met Leu His
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Asp Asp Thr Ala Val Tyr Phe Cys
85 90 95
Ala Lys Gly Asp Trp Ile Arg Tyr Phe Asp Trp Ser Leu Pro Ile Ser
100 105 110
Phe Phe Asp Tyr Trp Gly Gln Gly Ala Leu Val Thr Val Ser Ser
115 120 125
<210> 963
<211> 126
<212> PRT
<213> Homo sapiens
<400> 963
Glu Val Gln Leu Leu Glu Ser Gly Pro Gly Leu Leu Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Val Ser Ser Gly
20 25 30
Asn Phe Tyr Trp Ser Trp Val Arg Arg Pro Pro Gly Lys Ala Leu Glu
35 40 45
Trp Ile Ala Tyr Ser His Tyr Thr Gly Gly Thr Asn Ser Asp Pro Ser
50 55 60
Phe Met Gly Arg Val Thr Met Ser Ile Asp Pro Ser Arg Asn Gln Phe
65 70 75 80
Ser Leu Arg Leu Thr Ser Val Ala Ala Ala Asp Thr Ala Val Tyr Tyr
85 90 95
Cys Ala Arg Thr Thr Ser Pro Leu Thr Tyr Ser Gly His Trp Pro Leu
100 105 110
Phe Asp Tyr Trp Gly Gln Gly Ser Leu Val Thr Val Ser Ser
115 120 125
<210> 964
<211> 129
<212> PRT
<213> Homo sapiens
<400> 964
Gln Val Gln Leu Val Gln Ser Gly Asp Glu Met Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Asp Thr Phe Ser Thr His
20 25 30
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Pro Glu Trp Met
35 40 45
Gly Gly Ile Ile Pro Leu Phe Gly Thr Ala Ser Tyr Ala Gln Thr Ser
50 55 60
Gln Ser Arg Val Lys Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Val Arg Asp Ser Asp Pro Tyr Thr Ala Thr Ser Arg Asn Asn His Tyr
100 105 110
Trp Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser
115 120 125
Ser
<210> 965
<211> 126
<212> PRT
<213> Homo sapiens
<400> 965
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Met Phe Thr Asp Tyr
20 25 30
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met
35 40 45
Gly Gly Ile Met Pro Gly Leu Gly Ser Pro Ala Tyr Ala Gln Ile Phe
50 55 60
Arg Asp Arg Ala Thr Ile Ser Ala Asp Val Ser Thr Ser Thr Ala Tyr
65 70 75 80
Leu Glu Leu Thr Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Pro Ser Ile Leu Asn Thr Gly Asn His His Trp Tyr Asp
100 105 110
Leu Asp Ile Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 966
<211> 126
<212> PRT
<213> Homo sapiens
<400> 966
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Met Phe Thr Asp Tyr
20 25 30
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Arg Pro Glu Trp Met
35 40 45
Gly Gly Ile Met Pro Gly Leu Gly Ser Pro Ala Tyr Ala Gln Ile Phe
50 55 60
Arg Gly Arg Ala Thr Ile Ser Ala Asp Leu Ser Thr Ser Thr Ala Tyr
65 70 75 80
Leu Glu Leu Thr Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Pro Ser Ile Leu Asn Thr Gly Asn His His Trp Tyr Asp
100 105 110
Leu Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120 125
<210> 967
<211> 122
<212> PRT
<213> Homo sapiens
<400> 967
Gln Val Thr Leu Lys Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Asn Ser Tyr
20 25 30
Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Gly Phe Lys Ser Arg Ser Asp Arg Pro Asp Tyr Ala Glu Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys Asn Thr Val Tyr
65 70 75 80
Leu Glu Met Ile Gly Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr Cys
85 90 95
Val Arg Met Asp Trp Met Glu Trp Met Lys Tyr Tyr Phe Asp Ser Trp
100 105 110
Gly Gln Gly Ala Leu Val Thr Val Ser Ser
115 120
<210> 968
<211> 126
<212> PRT
<213> Homo sapiens
<400> 968
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Met Ile Ser Asp Tyr
20 25 30
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met
35 40 45
Gly Gly Ile Met Pro Ala Phe Gly Ser Pro Gly Tyr Ala Gln Ile Phe
50 55 60
Arg Gly Arg Ala Thr Ile Ser Ala Asp Val Ser Thr Asn Thr Ala Tyr
65 70 75 80
Leu Glu Leu Thr Ser Leu Asn Pro Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Pro Ser Ile Leu Asn Thr Gly Asn His His Trp Tyr Asp
100 105 110
Leu Asp Met Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120 125
<210> 969
<211> 127
<212> PRT
<213> Homo sapiens
<400> 969
Gln Val Gln Leu Val Glu Ser Gly Gly Ser Val Val Gln Pro Gly Thr
1 5 10 15
Ser Leu Lys Leu Ser Cys Ala Gly Ser Ala Gly Leu Thr Ile Thr Arg
20 25 30
Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp
35 40 45
Val Ala Leu Val Ser His Asp Gly Ile His Ile Gly Tyr Ser Asp Ser
50 55 60
Val Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Arg Asn Thr Leu
65 70 75 80
Tyr Leu Gln Met Asp Gly Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr
85 90 95
Cys Val Arg Asp Asp Val Leu Gln His Ser Arg Pro Ser Gly Pro Gly
100 105 110
Tyr Phe Val Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 970
<211> 127
<212> PRT
<213> Homo sapiens
<400> 970
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly
1 5 10 15
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Ala Ser Val Ser Ser Asp
20 25 30
His Trp Trp Ser Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp
35 40 45
Ile Gly Glu Val Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu
50 55 60
Lys Ser Arg Val Thr Ile Ser Leu Asp Gln Ser Asn Asn Gln Phe Ser
65 70 75 80
Leu Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr Cys
85 90 95
Ala Thr Met Trp Gly Gly Leu Cys Thr Ala Ser Asn Cys Tyr Gly Asn
100 105 110
Pro Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 971
<211> 116
<212> PRT
<213> Mus musculus
<400> 971
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Met Lys Phe Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asp Tyr
20 25 30
Trp Met Asn Trp Val Arg Gln Ser Pro Asp Lys Gly Leu Glu Trp Val
35 40 45
Ala Glu Ile Arg Leu Lys Ser Asn Asn Tyr Ala Thr His Tyr Ala Ala
50 55 60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser
65 70 75 80
Val Tyr Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Ser Gly Ile Tyr
85 90 95
Tyr Cys Thr Arg Ser Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val
100 105 110
Thr Val Ser Ser
115
<210> 972
<211> 111
<212> PRT
<213> Mus musculus
<400> 972
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu
1 5 10 15
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Ser Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Ser Lys Trp Met
35 40 45
Gly Trp Ile Asn Thr Glu Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe
50 55 60
Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr
65 70 75 80
Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys
85 90 95
Ala Leu Arg Arg Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
100 105 110
<210> 973
<211> 111
<212> PRT
<213> Mus musculus
<400> 973
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu
1 5 10 15
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Ser Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Ser Lys Trp Met
35 40 45
Gly Trp Ile Asn Thr Glu Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe
50 55 60
Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr
65 70 75 80
Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys
85 90 95
Ala Leu Arg Arg Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala
100 105 110
<210> 974
<211> 111
<212> PRT
<213> Mus musculus
<400> 974
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu
1 5 10 15
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Ser Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Ser Lys Trp Met
35 40 45
Gly Trp Ile Asn Thr Glu Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe
50 55 60
Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr
65 70 75 80
Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys
85 90 95
Ala Leu Arg Arg Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala
100 105 110
<210> 975
<211> 120
<212> PRT
<213> Mus musculus
<400> 975
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr
20 25 30
Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Leu Val
35 40 45
Ala Thr Ile Asn Arg Asn Gly Gly Ser Thr Tyr Tyr Leu Asp Ser Val
50 55 60
Lys Val Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Leu Phe
65 70 75 80
Leu Gln Leu Ser Ser Leu Lys Ser Asp Asp Thr Ala Met Tyr Tyr Cys
85 90 95
Ala Arg Ile Tyr Asp Phe Asp Glu Asp Tyr Phe Asp Val Trp Gly Ala
100 105 110
Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 976
<211> 120
<212> PRT
<213> Homo sapiens
<400> 976
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asn Tyr
20 25 30
Ala Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Gly Ile Ser Asp Ser Gly Asp Arg Thr Tyr Asn Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu His
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Leu Ala Ser Gly Ser Tyr Phe Gly Gly Ala Asn Tyr Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 977
<211> 119
<212> PRT
<213> Homo sapiens
<400> 977
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn
20 25 30
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Val
35 40 45
Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Thr Gly Ala Arg Phe Gly Glu Ser Pro Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 978
<211> 119
<212> PRT
<213> Homo sapiens
<400> 978
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn
20 25 30
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Thr Gly Ala Arg Phe Gly Glu Ser Pro Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 979
<211> 130
<212> PRT
<213> Homo sapiens
<400> 979
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Arg Tyr
20 25 30
Thr Ile Ile Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Arg Ile Ile Pro Ile Leu Asp Ile Ala Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu Gly Gly Leu Asp Tyr Phe Gly Ser Arg Asn Ser Gly Trp
100 105 110
Thr Tyr Thr Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val
115 120 125
Ser Ser
130
<210> 980
<211> 128
<212> PRT
<213> Homo sapiens
<400> 980
Gln Leu Gln Val Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala Ser Ile Ser Ser Asn
20 25 30
His Tyr Phe Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Ala
35 40 45
Trp Ile Gly Ser Met His Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser
50 55 60
Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Leu
65 70 75 80
Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
85 90 95
Cys Ala Arg Gly Val Asn Tyr Tyr Asp Arg Asn Gly Tyr Tyr Arg Asn
100 105 110
Asp Gly Phe Asp Ile Arg Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120 125
<210> 981
<211> 122
<212> PRT
<213> Homo sapiens
<400> 981
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Tyr Ile Ser Ser Ser Ser Asn Thr Arg Tyr Tyr Thr Asp Ser Val
50 55 60
Met Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ser Ser Lys Gly Phe Cys Ser Gly Gly Ser Cys Ser Asp Tyr Trp
100 105 110
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 982
<211> 124
<212> PRT
<213> Homo sapiens
<400> 982
Glu Val Gln Leu Val Glu Ser Gly Gly His Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His Trp Val Arg Gln Val Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Gly Ile Ser Trp Asn Gly Gly Ile Leu Asp Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu His Met Arg Ser Leu Arg Thr Asp Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Lys Asp Leu Arg Arg Gln Asp Tyr Tyr Ala Asp Trp Tyr Phe Asp
100 105 110
Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 983
<211> 128
<212> PRT
<213> Homo sapiens
<400> 983
Gln Leu Gln Val Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala Ser Ile Ser Ser Asn
20 25 30
His Tyr Phe Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Ala
35 40 45
Trp Ile Gly Ser Met His Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser
50 55 60
Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Leu
65 70 75 80
Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
85 90 95
Cys Ala Arg Gly Val Asn Tyr Tyr Asp Arg Asn Gly Tyr Tyr Arg Asn
100 105 110
Asp Gly Phe Asp Ile Arg Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120 125
<210> 984
<211> 124
<212> PRT
<213> Homo sapiens
<400> 984
Glu Val Gln Leu Val Glu Ser Gly Gly His Leu Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His Trp Val Arg Gln Val Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Gly Ile Ser Trp Asn Gly Gly Ile Leu Gly Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Arg Ser Leu Arg Thr Asp Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Lys Asp Leu Arg Arg Gln Asp Tyr Tyr Ala Asp Trp Tyr Phe Asp
100 105 110
Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 985
<211> 128
<212> PRT
<213> Homo sapiens
<400> 985
Gln Leu Gln Val Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala Ser Ile Ser Ser Asn
20 25 30
His Tyr Phe Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Ala
35 40 45
Trp Ile Gly Ser Met His Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser
50 55 60
Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Leu
65 70 75 80
Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
85 90 95
Cys Ala Arg Gly Val Asn Tyr Tyr Asp Arg Asn Gly Tyr Tyr Arg Asn
100 105 110
Asp Gly Phe Asp Ile Arg Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120 125
<210> 986
<211> 118
<212> PRT
<213> Homo sapiens
<400> 986
Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ile Phe Ile Asn Tyr
20 25 30
Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Ile Asn Thr Asn Thr Gly Asn Pro Thr Tyr Ala Gln Asp Phe
50 55 60
Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Leu Ser Thr Ala Tyr
65 70 75 80
Leu Gln Ile Ser Ser Leu Glu Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Ile Gly Ser Arg Asn Ser Leu Gly Val Trp Gly Gln Gly Thr
100 105 110
Leu Val Thr Val Ser Ala
115
<210> 987
<211> 123
<212> PRT
<213> Homo sapiens
<400> 987
Gln Met Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Thr
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Ser Ser
20 25 30
Ala Val Gln Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Ile
35 40 45
Gly Trp Ile Val Val Gly Ser Gly Asn Thr Asp Tyr Ala Gln Lys Phe
50 55 60
Gln Glu Arg Val Thr Ile Thr Arg Asp Val Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ala Pro Arg Cys Ser Gly Gly Ser Cys Tyr Asp Gly Phe Asp Ile
100 105 110
Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120
<210> 988
<211> 121
<212> PRT
<213> Lama pacos
<400> 988
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Ala Asn Thr
20 25 30
Trp Met Glu Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Thr Ser Tyr Gly Tyr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Asn Val Lys Asp Glu Gly Ala Thr Thr Lys Val Tyr Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 989
<211> 121
<212> PRT
<213> Lama pacos
<400> 989
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Met Tyr Thr
20 25 30
His Met His Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Val Ser Leu Gly Glu Tyr Thr Thr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Asn Val Lys Asp Trp Gly Ala Ala Asn Lys Tyr Tyr Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 990
<211> 121
<212> PRT
<213> Lama pacos
<400> 990
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Glu Val Trp
20 25 30
Arg Met Glu Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val
35 40 45
Ala Ala Ile Glu Ser Tyr Gly His Gly Thr Arg Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Asn Val Lys Asp Asp Gly Gln Leu Ala Tyr His Tyr Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 991
<211> 121
<212> PRT
<213> Lama pacos
<400> 991
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Glu Val Trp
20 25 30
Arg Met Glu Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val
35 40 45
Ala Ala Ile Glu Ser Tyr Gly Trp Gly Thr Arg Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Asn Val Lys Asp Asp Gly Gln Leu Ala Tyr His Tyr Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 992
<211> 121
<212> PRT
<213> Lama pacos
<400> 992
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Glu Val Trp
20 25 30
Arg Met Glu Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val
35 40 45
Ala Ala Ile Glu Ser Tyr Gly His Gly Thr Arg Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Asn Val Trp Asp Asp Gly Gln Leu Ala Tyr His Tyr Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 993
<211> 121
<212> PRT
<213> Lama pacos
<400> 993
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Glu Val Trp
20 25 30
Arg Met Glu Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val
35 40 45
Ala Ala Ile Glu Ser Tyr Gly His Gly Thr Arg Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Asn Val Tyr Asp Asp Gly Gln Leu Ala Tyr His Tyr Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 994
<211> 121
<212> PRT
<213> Lama pacos
<400> 994
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Tyr Phe Ser
20 25 30
Tyr Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Asn Ser Glu Gly Asp Ser Thr Thr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Asn Val Lys Asp Tyr Gly Trp Tyr Asn Ser Gln Tyr Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 995
<211> 120
<212> PRT
<213> Lama pacos
<400> 995
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Asn Ala His
20 25 30
Phe Met Tyr Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Tyr Ser Tyr Gly Arg Thr Leu Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn
85 90 95
Val Lys Asp Tyr Gly Ala Ala Ser Trp Glu Tyr Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 996
<211> 121
<212> PRT
<213> Lama pacos
<400> 996
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Met Tyr Ala Trp
20 25 30
Glu Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Arg Ser Met Gly Val His Thr His Tyr Ser Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Asn Val Lys Asp Phe Gly Gly His Gln Ala Tyr Tyr Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 997
<211> 121
<212> PRT
<213> Lama pacos
<400> 997
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Glu Asp Thr
20 25 30
Trp Met Glu Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Thr Ser Trp Gly Phe Lys Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Asn Val Lys Asp Glu Gly Asp Thr Ser Ala Ser Tyr Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 998
<211> 120
<212> PRT
<213> Lama pacos
<400> 998
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Asn Ser Trp
20 25 30
Met Glu Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val Ala
35 40 45
Ala Ile Thr Ser Tyr Gly Tyr Lys Thr Tyr Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn
85 90 95
Val Lys Asp Glu Gly Tyr Phe Ser Asp Glu Tyr Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 999
<211> 121
<212> PRT
<213> Lama pacos
<400> 999
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Glu Trp Ala
20 25 30
His Met His Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Val Ser Ala Gly His Tyr Thr Val Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Asn Val Lys Asp Trp Gly Ser Ser Asn Gln Tyr Tyr Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 1000
<211> 130
<212> PRT
<213> Lama pacos
<400> 1000
Asp Val Gln Leu Gln Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Tyr Tyr
20 25 30
Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val
35 40 45
Ser Cys Ile Ser Ser Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ser Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ala Val Pro Ser Thr Tyr Tyr Asn Gly Ser Tyr Tyr Tyr Thr Cys
100 105 110
His Pro Gly Gly Met Asp Tyr Trp Gly Lys Gly Thr Gln Val Thr Val
115 120 125
Ser Ser
130
<210> 1001
<211> 130
<212> PRT
<213> Lama pacos
<400> 1001
Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Leu Asp Tyr Tyr
20 25 30
Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val
35 40 45
Ser Cys Ile Ser Ser Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ser Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ala Val Pro Ser Thr Tyr Tyr Ser Gly Thr Tyr Tyr Tyr Asn Cys
100 105 110
His Pro Gly Gly Met Asp Tyr Trp Gly Lys Gly Thr Gln Val Thr Val
115 120 125
Ser Ser
130
<210> 1002
<211> 130
<212> PRT
<213> Lama pacos
<400> 1002
Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Leu Asp Tyr Tyr
20 25 30
Thr Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val
35 40 45
Ser Cys Ile Ser Ser Ser Asp Asp Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Thr Ala Pro Gly Thr Tyr Tyr Lys Gly Ser Tyr Tyr Pro Met Cys
100 105 110
His Tyr Tyr Gly Met Asp Tyr Trp Gly Lys Gly Thr Gln Val Thr Val
115 120 125
Ser Ser
130
<210> 1003
<211> 130
<212> PRT
<213> Lama pacos
<400> 1003
Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Leu Asp Tyr Tyr
20 25 30
Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val
35 40 45
Ala Cys Ile Ser Ser Ser Asp Gly Thr Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Thr Arg Pro Leu Thr Tyr Tyr Ser Gly Ser Tyr Tyr Thr Thr Cys
100 105 110
Ser Asp Tyr Gly Met Asp Tyr Trp Gly Lys Gly Thr Leu Val Thr Val
115 120 125
Ser Ser
130
<210> 1004
<211> 130
<212> PRT
<213> Lama pacos
<400> 1004
Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Tyr Tyr
20 25 30
Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val
35 40 45
Ser Cys Ile Ser Asn Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Thr Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ala Val Pro Ser Thr Tyr Tyr Ser Gly Ser Tyr Tyr Tyr Thr Cys
100 105 110
His Pro Gly Gly Met Asp Tyr Trp Gly Lys Gly Thr Gln Val Thr Val
115 120 125
Ser Ser
130
<210> 1005
<211> 130
<212> PRT
<213> Lama pacos
<400> 1005
Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ser Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Tyr Tyr
20 25 30
Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val
35 40 45
Ser Cys Ile Ser Asn Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Thr Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ala Val Pro Ser Thr Tyr Tyr Ser Gly Ser Tyr Tyr Tyr Thr Cys
100 105 110
His Pro Gly Gly Met Asp Tyr Trp Gly Lys Gly Thr Gln Val Thr Val
115 120 125
Ser Ser
130
<210> 1006
<211> 130
<212> PRT
<213> Lama pacos
<400> 1006
Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Tyr Tyr
20 25 30
Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val
35 40 45
Ser Cys Ile Ser Asn Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Thr Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ala Val Pro Ser Thr Tyr Tyr Ser Gly Ser Tyr Tyr Tyr Thr Cys
100 105 110
His Pro Gly Gly Met Asp Tyr Trp Gly Lys Gly Thr Leu Val Thr Val
115 120 125
Ser Ser
130
<210> 1007
<211> 130
<212> PRT
<213> Lama pacos
<400> 1007
Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Tyr Tyr
20 25 30
Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val
35 40 45
Ser Cys Ile Ser Asn Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Thr Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ala Val Pro Ser Thr Tyr Tyr Ser Gly Ser Tyr Tyr Tyr Thr Cys
100 105 110
His Pro Gly Gly Met Asp Tyr Trp Gly Lys Gly Thr Gln Val Thr Val
115 120 125
Ser Ser
130
<210> 1008
<211> 130
<212> PRT
<213> Lama pacos
<400> 1008
Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ser Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Tyr Tyr
20 25 30
Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val
35 40 45
Ser Cys Ile Thr Asn Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Thr Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ser Phe Pro Ser Thr Tyr Tyr Ser Gly Ser Tyr Tyr Tyr Thr Cys
100 105 110
His Pro Gly Gly Met Asp Tyr Trp Gly Lys Gly Thr Gln Val Thr Val
115 120 125
Ser Ser
130
<210> 1009
<211> 133
<212> PRT
<213> Lama pacos
<400> 1009
Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Tyr Tyr
20 25 30
Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val
35 40 45
Ser Cys Ile Ser Ser Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ala Ala Leu Ser Glu Gly Gly Tyr Thr Ile Asp Gly Ser Ser Trp
100 105 110
Cys Tyr His Ser Val Tyr Gly Met Asp Tyr Trp Gly Lys Gly Thr Gln
115 120 125
Val Thr Val Ser Ser
130
<210> 1010
<211> 130
<212> PRT
<213> Lama pacos
<400> 1010
Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Glu Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Val Thr Leu Asp Tyr Tyr
20 25 30
Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val
35 40 45
Ser Cys Ile Ser Ser Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Thr Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Asp Tyr Tyr Cys
85 90 95
Ala Ala Val Pro Ser Thr Tyr Tyr Ser Gly Thr Tyr Tyr Tyr Asn Cys
100 105 110
His Pro Gly Ala Met His Tyr Trp Gly Lys Gly Thr Gln Val Thr Val
115 120 125
Ser Ser
130
<210> 1011
<211> 130
<212> PRT
<213> Lama pacos
<400> 1011
Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Leu Asp Tyr Tyr
20 25 30
Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val
35 40 45
Ser Cys Ile Ser Ser Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Thr Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ala Val Pro Ser Thr Tyr Tyr Ser Gly Thr Tyr Tyr Tyr Thr Cys
100 105 110
His Pro Gly Gly Met Asp Tyr Trp Gly Lys Gly Thr Gln Val Thr Val
115 120 125
Ser Ser
130
<210> 1012
<211> 130
<212> PRT
<213> Lama pacos
<400> 1012
Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Leu Asp Tyr Tyr
20 25 30
Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val
35 40 45
Ser Cys Ile Ser Ser Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Thr Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ala Val Pro Ser Thr Tyr Tyr Ser Gly Thr Tyr Tyr Tyr Thr Cys
100 105 110
His Pro Gly Gly Met Asp Tyr Trp Gly Lys Gly Thr Leu Val Thr Val
115 120 125
Ser Ser
130
<210> 1013
<211> 127
<212> PRT
<213> Homo sapiens
<400> 1013
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Ser Ser Gly
20 25 30
Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp
35 40 45
Ile Gly Ser Ile Tyr His Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu
50 55 60
Lys Thr Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser
65 70 75 80
Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ala Val Val Gly Ile Val Val Val Pro Ala Ala Gly Arg Arg
100 105 110
Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120 125
<210> 1014
<211> 127
<212> PRT
<213> Homo sapiens
<400> 1014
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Pro Phe Thr Ser Tyr
20 25 30
Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Ile Ser Thr Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Thr Thr Gly Tyr
65 70 75 80
Met Glu Leu Arg Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Tyr Thr Arg Gly Ala Trp Phe Gly Glu Ser Leu Ile Gly
100 105 110
Gly Phe Asp Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 1015
<211> 114
<212> PRT
<213> Lama pacos
<400> 1015
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Arg Lys Ala
20 25 30
Asn Met His Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Met Ser Lys Gly Glu Gln Thr Val Tyr Ala Asp Ser Val
50 55 60
Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Arg Val Phe Val Gly Trp His Tyr Phe Gly Gln Gly Thr Gln Val Thr
100 105 110
Val Ser
<210> 1016
<211> 114
<212> PRT
<213> Lama pacos
<400> 1016
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Gln Ser His
20 25 30
Tyr Met Arg Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Glu Ser Thr Gly His His Thr Ala Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Thr Val Tyr Val Gly Tyr Glu Tyr His Gly Gln Gly Thr Gln Val Thr
100 105 110
Val Ser
<210> 1017
<211> 114
<212> PRT
<213> Lama pacos
<400> 1017
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Glu Thr Glu
20 25 30
Asn Met His Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Tyr Ser His Gly Met Trp Thr Ala Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Glu Val Glu Val Gly Lys Trp Tyr Phe Gly Gln Gly Thr Gln Val Thr
100 105 110
Val Ser
<210> 1018
<211> 114
<212> PRT
<213> Lama pacos
<400> 1018
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Lys Ala Ser
20 25 30
Arg Met Tyr Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Gln Ser Phe Gly Glu Val Thr Trp Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Tyr Val Trp Val Gly Gln Glu Tyr Trp Gly Gln Gly Thr Gln Val Thr
100 105 110
Val Ser
<210> 1019
<211> 114
<212> PRT
<213> Lama pacos
<400> 1019
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Tyr Ala Ser
20 25 30
Asn Met His Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Glu Ser Gln Gly Tyr Met Thr Ala Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Trp Val Ile Val Gly Glu Tyr Tyr Val Gly Gln Gly Thr Gln Val Thr
100 105 110
Val Ser
<210> 1020
<211> 114
<212> PRT
<213> Lama pacos
<400> 1020
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Gln Ala Arg
20 25 30
Glu Met Glu Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Lys Ser Thr Gly Thr Tyr Thr Ala Tyr Ala Tyr Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Tyr Val Tyr Val Gly Ser Ser Tyr Ile Gly Gln Gly Thr Gln Val Thr
100 105 110
Val Ser
<210> 1021
<211> 114
<212> PRT
<213> Lama pacos
<400> 1021
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Lys Asn Phe
20 25 30
Glu Met Glu Trp Tyr Arg Lys Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Gln Ser Gly Gly Val Glu Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Phe Val Tyr Val Gly Arg Ser Tyr Ile Gly Gln Gly Thr Gln Val Thr
100 105 110
Val Ser
<210> 1022
<211> 115
<212> PRT
<213> Lama pacos
<400> 1022
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Ala Tyr Lys
20 25 30
Thr Met Trp Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Glu Ser Tyr Gly Ile Lys Trp Thr Arg Tyr Ala Asp Ser
50 55 60
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val
65 70 75 80
Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr
85 90 95
Cys Ile Val Trp Val Gly Ala Gln Tyr His Gly Gln Gly Thr Gln Val
100 105 110
Thr Val Ser
115
<210> 1023
<211> 114
<212> PRT
<213> Lama pacos
<400> 1023
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Ala Gly Arg
20 25 30
Asn Met Trp Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Tyr Ser Ser Gly Thr Tyr Thr Glu Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
His Val Trp Val Gly Ser Leu Tyr Lys Gly Gln Gly Thr Gln Val Thr
100 105 110
Val Ser
<210> 1024
<211> 114
<212> PRT
<213> Lama pacos
<400> 1024
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Lys His Ala
20 25 30
Arg Met Trp Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Asp Ser His Gly Asp Thr Thr Trp Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Tyr Val Tyr Val Gly Ala Ser Tyr Trp Gly Gln Gly Thr Gln Val Thr
100 105 110
Val Ser
<210> 1025
<211> 114
<212> PRT
<213> Lama pacos
<400> 1025
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Asn Ser His
20 25 30
Glu Met Thr Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Gln Ser Thr Gly Thr Val Thr Glu Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Tyr Val Tyr Val Gly Ser Ser Tyr Leu Gly Gln Gly Thr Gln Val Thr
100 105 110
Val Ser
<210> 1026
<211> 115
<212> PRT
<213> Lama pacos
<400> 1026
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Pro Val Tyr Gln Ala
20 25 30
Asn Met His Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Gln Ser Tyr Gly Asp Gly Thr His Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Arg Ala Val Tyr Val Gly Met His Tyr Phe Gly Gln Gly Thr Gln Val
100 105 110
Thr Val Ser
115
<210> 1027
<211> 114
<212> PRT
<213> Lama pacos
<400> 1027
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Glu Gln Arg
20 25 30
Glu Met Glu Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Asp Ser Asn Gly Asn Tyr Thr Phe Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Tyr Val Tyr Val Gly Lys Ser Tyr Ile Gly Gln Gly Thr Gln Val Thr
100 105 110
Val Ser
<210> 1028
<211> 114
<212> PRT
<213> Lama pacos
<400> 1028
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Lys His His
20 25 30
Trp Met Phe Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Lys Ser Tyr Gly Tyr Gly Thr Glu Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Phe Val Gly Val Gly Thr His Tyr Ala Gly Gln Gly Thr Gln Val Thr
100 105 110
Val Ser
<210> 1029
<211> 114
<212> PRT
<213> Lama pacos
<400> 1029
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Tyr Ala Ala
20 25 30
Glu Met Glu Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Ser Ser Gln Gly Thr Ile Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Phe Val Tyr Val Gly Lys Ser Tyr Ile Gly Gln Gly Thr Gln Val Ser
100 105 110
Val Ser
<210> 1030
<211> 114
<212> PRT
<213> Lama pacos
<400> 1030
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Tyr Ala Ala
20 25 30
Glu Met Glu Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Ser Ser Gln Gly Thr Ile Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Phe Val Tyr Val Gly Lys Ser Tyr Ile Gly Gln Gly Thr Gln Val Ser
100 105 110
Val Ser
<210> 1031
<211> 120
<212> PRT
<213> Lama pacos
<400> 1031
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val His Ala Trp
20 25 30
Glu Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Arg Ser Phe Gly Ser Ser Thr His Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Asn Val Lys Asp Phe Gly Thr His His Tyr Ala Tyr Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Gln Val Thr Val Ser
115 120
<210> 1032
<211> 120
<212> PRT
<213> Lama pacos
<400> 1032
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Asn Thr Trp
20 25 30
Trp Met His Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Thr Ser Trp Gly Phe Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Asn Val Lys Asp Lys Gly Met Ala Val Gln Trp Tyr Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Gln Val Thr Val Ser
115 120
<210> 1033
<211> 120
<212> PRT
<213> Lama pacos
<400> 1033
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Tyr Asn Thr
20 25 30
Trp Met Glu Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Thr Ser His Gly Tyr Lys Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Asn Val Lys Asp Glu Gly Asp Met Phe Thr Ala Tyr Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Gln Val Thr Val Ser
115 120
<210> 1034
<211> 120
<212> PRT
<213> Lama pacos
<400> 1034
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Tyr His Ser
20 25 30
Thr Met Phe Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Tyr Ser Ser Gly Gln His Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Asn Val Lys Asp Ser Gly Gln Trp Arg Gln Glu Tyr Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Gln Val Thr Val Ser
115 120
<210> 1035
<211> 119
<212> PRT
<213> Lama pacos
<400> 1035
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Glu His Glu
20 25 30
Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val Ala
35 40 45
Ala Ile Arg Ser Met Gly Arg Lys Thr Leu Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn
85 90 95
Val Lys Asp Phe Gly Tyr Thr Trp His Glu Tyr Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Gln Val Thr Val Ser
115
<210> 1036
<211> 114
<212> PRT
<213> Lama pacos
<400> 1036
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Asn Tyr Lys
20 25 30
Thr Met Trp Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Trp Ser Tyr Gly His Thr Thr His Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Val Val Trp Val Gly His Asn Tyr Glu Gly Gln Gly Thr Gln Val Thr
100 105 110
Val Ser
<210> 1037
<211> 120
<212> PRT
<213> Lama pacos
<400> 1037
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Thr Met Ala
20 25 30
Trp Met Trp Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Arg Ser Glu Gly Val Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Asn Val Lys Asp Tyr Gly Gln Ala His Ala Tyr Tyr Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Gln Val Thr Val Ser
115 120
<210> 1038
<211> 120
<212> PRT
<213> Lama pacos
<400> 1038
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Asn Ser His
20 25 30
Phe Met Glu Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Gln His Ser Ser Gly Phe His Thr Tyr Tyr Ala Asp Ser
50 55 60
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val
65 70 75 80
Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr
85 90 95
Cys Asn Val Lys Asp Thr Gly Thr Thr Glu Asp Tyr Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Gln Val Thr Val Ser
115 120
<210> 1039
<211> 120
<212> PRT
<213> Lama pacos
<400> 1039
Gln Val Gln Leu Asp Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Tyr His Ala
20 25 30
Trp Met Glu Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Thr Ser Ser Gly Arg His Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Asn Val Lys Asp Ala Gly Arg Val Tyr Asn Ser Tyr Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Gln Val Thr Val Ser
115 120
<210> 1040
<211> 120
<212> PRT
<213> Lama pacos
<400> 1040
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Ala His Ala
20 25 30
Trp Met Glu Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Thr Ser Tyr Gly Tyr Lys Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Asn Val Lys Asp Thr Gly Thr Tyr Arg Phe Tyr Tyr Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Gln Val Thr Val Ser
115 120
<210> 1041
<211> 119
<212> PRT
<213> Lama pacos
<400> 1041
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Trp Asn Gln
20 25 30
Thr Met Val Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Trp Ser Met Gly His Thr Tyr Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn
85 90 95
Val Lys Asp Ala Gly Val Tyr Asn Arg Tyr Tyr Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Gln Val Thr Val Ser
115
<210> 1042
<211> 120
<212> PRT
<213> Lama pacos
<400> 1042
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Glu His Tyr
20 25 30
Trp Met Glu Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Thr Ser Phe Gly Tyr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Asn Val Lys Asp Trp Gly Phe Ala Ser His Ala Tyr Asp Tyr Trp Gly
100 105 110
Gln Gly Ile Gln Val Thr Val Ser
115 120
<210> 1043
<211> 120
<212> PRT
<213> Lama pacos
<400> 1043
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Glu Ile Ala Trp
20 25 30
Glu Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Arg Ser Phe Gly Glu Arg Thr Leu Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Asn Val Lys Asp Phe Gly Trp Gln His Gln Glu Tyr Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Gln Val Thr Val Ser
115 120
<210> 1044
<211> 120
<212> PRT
<213> Lama pacos
<400> 1044
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Tyr His Ala
20 25 30
Tyr Met Glu Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Tyr Ser Asn Gly Glu His Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Asn Val Lys Asp Ser Gly Ser Phe Asn Gln Ala Tyr Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Gln Val Thr Val Ser
115 120
<210> 1045
<211> 120
<212> PRT
<213> Lama pacos
<400> 1045
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Glu Trp Ser
20 25 30
His Met His Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Val Ser Lys Gly Gly Tyr Thr Leu Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Asn Val Lys Asp Tyr Gly Val His Phe Lys Arg Tyr Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Gln Val Thr Val Ile
115 120
<210> 1046
<211> 120
<212> PRT
<213> Lama pacos
<400> 1046
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Phe His Val
20 25 30
Trp Met Glu Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Asp Ser Ala Gly Trp His Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Asn Val Lys Asp Ala Gly Asn Thr Thr Ser Ala Tyr Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Gln Val Thr Val Ser
115 120
<210> 1047
<211> 114
<212> PRT
<213> Lama pacos
<400> 1047
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Tyr Ala Gln
20 25 30
Asn Met His Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Tyr Ser His Gly Tyr Trp Thr Leu Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Glu Val Gln Val Gly Ala Trp Tyr Thr Gly Gln Gly Thr Gln Val Thr
100 105 110
Val Ser
<210> 1048
<211> 120
<212> PRT
<213> Lama pacos
<400> 1048
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Tyr Tyr Asn
20 25 30
Trp Met Glu Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile His Ser Asn Gly Asp Glu Thr Phe Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Asn Val Lys Asp Ile Asp Ala Glu Ala Tyr Ala Tyr Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Gln Val Thr Val Ser
115 120
<210> 1049
<211> 120
<212> PRT
<213> Lama pacos
<400> 1049
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Tyr His Val
20 25 30
Trp Met Glu Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Thr Ser Ser Gly Ser His Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Asn Val Lys Asp Ser Gly Gln Trp Arg Val Gln Tyr Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Gln Val Thr Val Ser
115 120
<210> 1050
<211> 120
<212> PRT
<213> Lama pacos
<400> 1050
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Tyr Trp His
20 25 30
His Met His Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Ile Ser Trp Gly Trp Tyr Thr Thr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Asn Val Lys Asp His Gly Ala Gln Asn Gln Met Tyr Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Gln Val Thr Val Ser
115 120
<210> 1051
<211> 120
<212> PRT
<213> Lama pacos
<400> 1051
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Tyr Arg Asp
20 25 30
Arg Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Tyr Ser Ala Gly Gln Gln Thr Arg Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Asn Val Lys Asp Val Gly His His Tyr Glu Tyr Tyr Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Gln Val Thr Val Ser
115 120
<210> 1052
<211> 120
<212> PRT
<213> Lama pacos
<400> 1052
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Asp Asn Gly
20 25 30
Tyr Met His Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Asp Ser Tyr Gly Trp His Thr Ile Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Asn Val Lys Asp Lys Gly Gln Met Arg Ala Ala Tyr Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Gln Val Thr Val Ser
115 120
<210> 1053
<211> 120
<212> PRT
<213> Lama pacos
<400> 1053
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Ser Trp His
20 25 30
Ser Met Tyr Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Phe Ser Glu Gly Asp Trp Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Asn Val Lys Asp Tyr Gly Ser Ser Tyr Tyr Lys Tyr Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Gln Val Thr Val Ser
115 120
<210> 1054
<211> 120
<212> PRT
<213> Lama pacos
<400> 1054
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Ser Gln Ser
20 25 30
Val Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Tyr Ser Lys Gly Gln Tyr Thr His Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Asn Val Lys Asp Ala Gly Ser Ser Tyr Trp Asp Tyr Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Gln Val Thr Val Ser
115 120
<210> 1055
<211> 124
<212> PRT
<213> Lama pacos
<400> 1055
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Gly Gln Ile Glu
20 25 30
Tyr Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val
35 40 45
Ala Ala Leu Asn Thr Trp Thr Gly Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Val Ser Leu Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Ala Ala Arg Trp Gly Arg Thr Lys Pro Leu Asn Thr Tyr Tyr Tyr
100 105 110
Ser Tyr Trp Gly Gln Gly Thr Pro Val Thr Val Ser
115 120
<210> 1056
<211> 114
<212> PRT
<213> Lama pacos
<400> 1056
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Phe Ser Gly
20 25 30
His Met His Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Leu Ser Asn Gly Asp Ser Thr His Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Arg Val His Val Gly Ala His Tyr Phe Gly Gln Gly Thr Gln Val Thr
100 105 110
Val Ser
<210> 1057
<211> 123
<212> PRT
<213> Lama pacos
<400> 1057
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ile Asp Lys Ile Val
20 25 30
Tyr Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val
35 40 45
Ala Ala Leu Tyr Thr Leu Ser Gly His Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Val Ser Leu Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Ala Ala Thr Glu Gly His Ala His Ala Leu Tyr Arg Leu His Tyr
100 105 110
Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser
115 120
<210> 1058
<211> 114
<212> PRT
<213> Lama pacos
<400> 1058
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Tyr Gln Gly
20 25 30
Glu Met His Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Arg Ser Thr Gly Val Gln Thr Trp Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Arg Val Trp Val Gly Thr His Tyr Phe Gly Gln Gly Thr Gln Val Thr
100 105 110
Val Ser
<210> 1059
<211> 124
<212> PRT
<213> Lama pacos
<400> 1059
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Ile Gln Arg Ile Tyr
20 25 30
Tyr Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val
35 40 45
Ala Ala Leu Met Thr Tyr Thr Gly His Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Val Ser Leu Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Ala Ala Tyr Val Gly Ala Glu Asn Pro Leu Pro Tyr Ser Met Tyr
100 105 110
Gly Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser
115 120
<210> 1060
<211> 124
<212> PRT
<213> Lama pacos
<400> 1060
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gln Ile Ser His Ile Lys
20 25 30
Tyr Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val
35 40 45
Ala Ala Leu Ile Thr Arg Trp Gly Gln Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Val Ser Leu Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Ala Ala Asp Tyr Gly Ala Ser Asp Pro Leu Trp Phe Ile His Tyr
100 105 110
Leu Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser
115 120
<210> 1061
<211> 124
<212> PRT
<213> Lama pacos
<400> 1061
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Lys Ile Trp Thr Ile Lys
20 25 30
Tyr Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val
35 40 45
Ala Ala Leu Met Thr Arg Trp Gly Tyr Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Val Ser Leu Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Ala Ala Asn Tyr Gly Ser Asn Phe Pro Leu Ala Glu Glu Asp Tyr
100 105 110
Trp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser
115 120
<210> 1062
<211> 125
<212> PRT
<213> Lama pacos
<400> 1062
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Ile Ser Gln Ile His
20 25 30
Tyr Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val
35 40 45
Ala Ala Leu Asn Thr Asp Tyr Gly Tyr Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Val Ser Leu Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Ala Ala Tyr Tyr Phe Gly Asp Asp Ile Pro Leu Trp Trp Glu Ala
100 105 110
Tyr Ser Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser
115 120 125
<210> 1063
<211> 124
<212> PRT
<213> Lama pacos
<400> 1063
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Ile Ser Thr Ile Glu
20 25 30
Tyr Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val
35 40 45
Ala Ala Leu Tyr Thr Trp His Gly Gln Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Val Ser Leu Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Ala Ala Arg Trp Gly Arg His Met Pro Leu Ser Ala Thr Glu Tyr
100 105 110
Ser Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser
115 120
<210> 1064
<211> 124
<212> PRT
<213> Lama pacos
<400> 1064
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Ile Glu Ser Ile Tyr
20 25 30
Tyr Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val
35 40 45
Ala Ala Leu Trp Thr Gly Asp Gly Glu Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Val Ser Leu Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Ala Ala Ala Trp Gly Asn Ser Ala Pro Leu Thr Thr Tyr Arg Tyr
100 105 110
Tyr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser
115 120
<210> 1065
<211> 114
<212> PRT
<213> Lama pacos
<400> 1065
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Glu Gln Gly
20 25 30
Arg Met Tyr Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Ile Ser His Gly Thr Val Thr Val Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Tyr Val Tyr Val Gly Ala Gln Tyr Trp Gly Gln Gly Thr Gln Val Thr
100 105 110
Val Ser
<210> 1066
<211> 124
<212> PRT
<213> Lama pacos
<400> 1066
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Tyr Gly Ile Thr
20 25 30
Tyr Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val
35 40 45
Ala Ala Leu Val Thr Trp Asn Gly Gln Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Val Ser Leu Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Ala Ala Asp Trp Gly Tyr Asp Trp Pro Leu Trp Asp Glu Trp Tyr
100 105 110
Trp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser
115 120
<210> 1067
<211> 124
<212> PRT
<213> Lama pacos
<400> 1067
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Ile Ala Asp Ile Lys
20 25 30
Tyr Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val
35 40 45
Ala Ala Leu Met Thr Arg Trp Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Val Ser Leu Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Ala Ala Asn Tyr Gly Ala Asn Tyr Pro Leu Tyr Ser Gln Gln Tyr
100 105 110
Ser Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser
115 120
<210> 1068
<211> 124
<212> PRT
<213> Lama pacos
<400> 1068
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ser Ser Ile Lys
20 25 30
Tyr Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val
35 40 45
Ala Ala Leu Met Thr Arg Trp Gly Met Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Val Ser Leu Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Ala Ala Asn Tyr Gly Ala Asn Glu Pro Leu Gln Tyr Thr His Tyr
100 105 110
Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser
115 120
<210> 1069
<211> 124
<212> PRT
<213> Lama pacos
<400> 1069
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Glu Ile Glu Ser Ile Phe
20 25 30
Tyr Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val
35 40 45
Ala Ala Leu Tyr Thr Tyr Val Gly Gln Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Val Ser Leu Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Ala Ala Ser Tyr Gly Ala Ala His Pro Leu Ser Ile Met Arg Tyr
100 105 110
Tyr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser
115 120
<210> 1070
<211> 124
<212> PRT
<213> Lama pacos
<400> 1070
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Ile Ala His Ile Lys
20 25 30
Tyr Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val
35 40 45
Ala Ala Leu Met Thr Lys Trp Gly Gln Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Val Ser Leu Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Ala Ala Ser Tyr Gly Ala Asn Phe Pro Leu Lys Ala Ser Asp Tyr
100 105 110
Ser Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser
115 120
<210> 1071
<211> 124
<212> PRT
<213> Lama pacos
<400> 1071
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Gln Ala Ile Thr
20 25 30
Tyr Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val
35 40 45
Ala Ala Leu Val Thr Trp Asn Gly Gln Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Val Ser Leu Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Ala Ala Asp Trp Gly Tyr Asp Trp Pro Leu Trp Asp Glu Trp Tyr
100 105 110
Trp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser
115 120
<210> 1072
<211> 124
<212> PRT
<213> Lama pacos
<400> 1072
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ser Ser Ile Thr
20 25 30
Tyr Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val
35 40 45
Ala Ala Leu Val Thr Tyr Ser Gly Asn Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Val Ser Leu Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Ala Ala Thr Trp Gly His Ser Trp Pro Leu Tyr Asn Asp Glu Tyr
100 105 110
Trp Tyr Trp Gly Gln Gly Ser Gln Val Thr Val Ser
115 120
<210> 1073
<211> 124
<212> PRT
<213> Lama pacos
<400> 1073
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ser Ser Ile Thr
20 25 30
Tyr Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val
35 40 45
Ala Ala Leu Ile Thr Val Asn Gly His Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Val Ser Leu Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Ala Ala Ala Trp Gly Tyr Ala Trp Pro Leu His Gln Asp Asp Tyr
100 105 110
Trp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser
115 120
<210> 1074
<211> 124
<212> PRT
<213> Lama pacos
<400> 1074
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ser Ser Ile Thr
20 25 30
Tyr Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val
35 40 45
Ala Ala Leu Asn Thr Phe Asn Gly Thr Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Val Ser Leu Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Ala Ala Thr Trp Gly Tyr Ser Trp Pro Leu Ile Ala Glu Tyr Asn
100 105 110
Trp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser
115 120
<210> 1075
<211> 114
<212> PRT
<213> Lama pacos
<400> 1075
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Leu Phe Thr
20 25 30
Tyr Met His Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Trp Ser Ser Gly Asn Ser Thr Trp Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Phe Val Lys Val Gly Asn Trp Tyr Ala Gly Gln Gly Thr Gln Val Thr
100 105 110
Val Ser
<210> 1076
<211> 124
<212> PRT
<213> Lama pacos
<400> 1076
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ser Ser Ile Thr
20 25 30
Tyr Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val
35 40 45
Ala Ala Leu Lys Thr Gln Ala Gly Phe Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Val Ser Leu Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Ala Ala Asn Trp Gly Tyr Ser Trp Pro Leu Tyr Glu Ala Asp Asp
100 105 110
Trp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser
115 120
<210> 1077
<211> 114
<212> PRT
<213> Lama pacos
<400> 1077
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Asn Ala Gly
20 25 30
Asn Met His Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Gln Ser Tyr Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Arg Val Phe Val Gly Met His Tyr Phe Gly Gln Gly Thr Gln Val Thr
100 105 110
Val Ser
<210> 1078
<211> 114
<212> PRT
<213> Lama pacos
<400> 1078
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Ser Ser Ser
20 25 30
Thr Met Thr Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Asn Ser Tyr Gly Trp Glu Thr His Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Tyr Val Tyr Val Gly Gly Ser Tyr Ile Gly Gln Gly Thr Gln Val Thr
100 105 110
Val Ser
<210> 1079
<211> 125
<212> PRT
<213> Lama pacos
<400> 1079
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ser Ser Ile Thr
20 25 30
Tyr Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val
35 40 45
Ala Ala Leu Val Thr Ser Asp Gly Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Val Ser Leu Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Ala Ala Asn Trp Gly Tyr Ser Trp Pro Leu Tyr Gln Thr Glu Tyr
100 105 110
Trp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120 125
<210> 1080
<211> 115
<212> PRT
<213> Lama pacos
<400> 1080
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Gln Leu Tyr
20 25 30
Trp Met Glu Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Thr Ser Asp Gly Asp Tyr Thr Glu Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Tyr Val Lys Val Gly Glu Trp Tyr Tyr Gly Gln Gly Thr Gln Val Thr
100 105 110
Val Ser Ser
115
<210> 1081
<211> 115
<212> PRT
<213> Lama pacos
<400> 1081
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Glu Asn Tyr
20 25 30
Tyr Met Arg Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Glu Ser Ser Gly Ala Glu Thr Arg Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Tyr Val Val Val Gly Trp Gly Tyr Ala Gly Gln Gly Thr Gln Val Thr
100 105 110
Val Ser Ser
115
<210> 1082
<211> 115
<212> PRT
<213> Lama pacos
<400> 1082
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Tyr Glu His
20 25 30
Tyr Met Arg Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Gln Ser His Gly Asn His Thr Ala Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Phe Val Val Val Gly Asn Gly Tyr Thr Gly Gln Gly Thr Gln Val Thr
100 105 110
Val Ser Ser
115
<210> 1083
<211> 115
<212> PRT
<213> Lama pacos
<400> 1083
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Arg Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Ala Ser Gln
20 25 30
Glu Met Thr Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Ser Ser Ser Gly Arg Gln Thr Glu Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Tyr Val Tyr Val Gly Gly Ser Tyr Ile Gly Gln Gly Thr Gln Val Thr
100 105 110
Val Ser Ser
115
<210> 1084
<211> 115
<212> PRT
<213> Lama pacos
<400> 1084
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Lys Ala Ser
20 25 30
Glu Met Glu Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Ala Ser Ile Gly Tyr Asn Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Leu Val Tyr Val Gly Ala Thr Tyr Ile Gly Gln Gly Thr Gln Val Thr
100 105 110
Val Ser Ser
115
<210> 1085
<211> 115
<212> PRT
<213> Lama pacos
<400> 1085
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Ser Asn Glu
20 25 30
Glu Met Thr Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Ala Ser Asn Gly Asn Gln Thr Glu Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Tyr Val Tyr Val Gly Ala Ser Tyr Ile Gly Gln Gly Thr Gln Val Thr
100 105 110
Val Ser Ser
115
<210> 1086
<211> 115
<212> PRT
<213> Lama pacos
<400> 1086
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Lys Glu Ser
20 25 30
Glu Met Thr Trp Tyr Arg Gln Ala Arg Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Asn Ser His Gly Met Thr Thr His Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Tyr Val Tyr Val Gly Gly Ser Tyr Ile Gly Gln Gly Thr Gln Val Thr
100 105 110
Val Ser Ser
115
<210> 1087
<211> 116
<212> PRT
<213> Lama pacos
<400> 1087
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Asn His Tyr
20 25 30
Glu Met Glu Trp Tyr Arg Gln Ala Pro Gly Arg Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Met Asp Ser Thr Gly Tyr Glu Thr Ala Tyr Ala Asp Ser
50 55 60
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val
65 70 75 80
Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr
85 90 95
Cys Tyr Val Tyr Val Gly Ala Ser Tyr Ile Gly Gln Gly Thr Gln Val
100 105 110
Thr Val Ser Ser
115
<210> 1088
<211> 115
<212> PRT
<213> Lama pacos
<400> 1088
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Glu Ser Glu
20 25 30
Asn Met His Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Tyr Ser Thr Gly Gly Trp Thr Leu Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Val Gln Val Gly Tyr Trp Tyr Glu Gly Gln Gly Thr Gln Val Thr
100 105 110
Val Ser Ser
115
<210> 1089
<211> 115
<212> PRT
<213> Lama pacos
<400> 1089
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Glu Ser Thr
20 25 30
Glu Met Thr Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Glu Ser Glu Gly His Gly Thr Glu Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Tyr Val Tyr Val Gly Ala Gly Tyr Ile Gly Gln Gly Thr Gln Val Thr
100 105 110
Val Ser Ser
115
<210> 1090
<211> 115
<212> PRT
<213> Lama pacos
<400> 1090
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Lys Ala Ser
20 25 30
Glu Met Val Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Leu Ser Gln Gly His Ala Thr Glu Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Tyr Val Trp Val Gly Arg Ser Tyr Ile Gly Gln Gly Thr Gln Val Thr
100 105 110
Val Ser Ser
115
<210> 1091
<211> 115
<212> PRT
<213> Lama pacos
<400> 1091
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Tyr Ser Ala
20 25 30
Glu Met Glu Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Ser Ser Tyr Gly Thr Asn Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Tyr Val Tyr Val Gly Ser Ser Tyr Ile Gly Gln Gly Thr Gln Val Thr
100 105 110
Val Ser Ser
115
<210> 1092
<211> 115
<212> PRT
<213> Lama pacos
<400> 1092
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Trp Tyr Lys
20 25 30
Glu Met Glu Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Thr Ser Ala Gly His His Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Tyr Val Tyr Val Gly Glu Ser Tyr Ile Gly Gln Gly Thr Gln Val Thr
100 105 110
Val Ser Ser
115
<210> 1093
<211> 115
<212> PRT
<213> Lama pacos
<400> 1093
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Ala His Lys
20 25 30
Ser Met Trp Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Glu Ser Thr Gly Asp Thr Thr Arg Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Val Val Trp Val Gly Glu Val Tyr Arg Gly Gln Gly Thr Gln Val Thr
100 105 110
Val Ser Ser
115
<210> 1094
<211> 121
<212> PRT
<213> Lama pacos
<400> 1094
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Tyr Asn Thr
20 25 30
Trp Met Glu Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Thr Ser Tyr Gly Phe His Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Asn Val Lys Asp Glu Gly Asn Thr Thr Ala Tyr Tyr Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 1095
<211> 121
<212> PRT
<213> Lama pacos
<400> 1095
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Tyr Trp Ala
20 25 30
His Met Thr Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Val Ser Ser Gly Ala Tyr Thr Ala Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Asn Val Lys Asp Phe Gly Thr Gln Glu His Tyr Tyr Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 1096
<211> 121
<212> PRT
<213> Lama pacos
<400> 1096
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Pro Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Met Trp Ser
20 25 30
His Met His Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Val Ser Tyr Gly Ala Tyr Thr Ile Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Asn Val Lys Asp Phe Gly Gly Tyr Arg Tyr Tyr Tyr Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 1097
<211> 121
<212> PRT
<213> Lama pacos
<400> 1097
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Gln Gly Thr
20 25 30
Trp Met Glu Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Thr Ser Val Gly Tyr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Asn Val Lys Asp Glu Gly Ala Ile Ala Lys Asn Tyr Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 1098
<211> 121
<212> PRT
<213> Lama pacos
<400> 1098
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Tyr Asn Thr
20 25 30
Trp Met Glu Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Thr Ser Trp Gly Phe Lys Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Asn Val Lys Asp Glu Gly Tyr Thr Gly Tyr Tyr Tyr Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 1099
<211> 121
<212> PRT
<213> Lama pacos
<400> 1099
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Glu Trp Thr
20 25 30
His Met His Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Ala Ser Ser Gly Ala Tyr Thr Val Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Asn Val Lys Asp Trp Gly Ser Gln Asp Arg Tyr Tyr Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 1100
<211> 121
<212> PRT
<213> Lama pacos
<400> 1100
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Ala Gly Thr
20 25 30
Trp Met Glu Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Thr Ser Tyr Gly Tyr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Asn Val Lys Asp Glu Gly Lys Ser Ser Gln Val Tyr Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 1101
<211> 121
<212> PRT
<213> Lama pacos
<400> 1101
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Asn Tyr Thr
20 25 30
Ile Met Phe Trp Tyr Arg Lys Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Lys Ser His Gly Ala Thr Thr Leu Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Asn Val Lys Asp Val Gly Asn Asp Gln Lys Ser Tyr Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 1102
<211> 121
<212> PRT
<213> Lama pacos
<400> 1102
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Val Trp Ala
20 25 30
His Met His Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Thr Ser Glu Gly Ala His Thr Ile Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Asn Val Lys Asp Trp Gly Thr Tyr Ser Thr Tyr Tyr Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 1103
<211> 115
<212> PRT
<213> Lama pacos
<400> 1103
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Ala Gln Gln
20 25 30
Glu Met Thr Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Ser Ser Ile Gly Ser Ile Thr His Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Tyr Val Tyr Val Gly Ala Ser Tyr Ile Gly Gln Gly Thr Gln Val Thr
100 105 110
Val Ser Ser
115
<210> 1104
<211> 121
<212> PRT
<213> Lama pacos
<400> 1104
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Gln Tyr Glu
20 25 30
His Met His Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Val Ser Glu Gly Ala Tyr Thr His Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Asn Val Lys Asp Trp Gly Trp Leu Ala Gln Tyr Tyr Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 1105
<211> 121
<212> PRT
<213> Lama pacos
<400> 1105
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Asn Tyr Asn
20 25 30
Trp Met Glu Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Thr Ser Trp Gly Tyr Lys Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Asn Val Lys Asp Glu Gly Met Trp Gln His Tyr Tyr Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 1106
<211> 121
<212> PRT
<213> Lama pacos
<400> 1106
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Trp Asn Thr
20 25 30
Trp Met Glu Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Thr Ser Tyr Gly Phe Lys Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Asn Val Lys Asp Glu Gly Asn Ser Gln Ser His Tyr Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 1107
<211> 121
<212> PRT
<213> Lama pacos
<400> 1107
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Glu Met Trp
20 25 30
Ser Met Glu Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Met Ser Phe Gly Tyr Gln Thr Trp Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Asn Val Lys Asp Ala Gly Asn Ser Lys Ala Leu Tyr Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 1108
<211> 121
<212> PRT
<213> Lama pacos
<400> 1108
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Glu His Asp
20 25 30
His Met His Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Val Ser Gln Gly Ala Tyr Thr Val Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Asn Val Lys Asp Trp Gly Arg Ala Gly Ala Arg Tyr Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 1109
<211> 121
<212> PRT
<213> Lama pacos
<400> 1109
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Asp Ala Ala
20 25 30
Trp Met Glu Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Thr Ser Tyr Gly Tyr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Asn Val Lys Asp Met Asp Arg Trp Arg Thr Thr Tyr Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 1110
<211> 115
<212> PRT
<213> Lama pacos
<400> 1110
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Asn His Thr
20 25 30
Arg Met Tyr Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Gln Ser His Gly Gln Asn Thr Phe Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Tyr Val Trp Val Gly Asn Gln Tyr Trp Gly Gln Gly Thr Gln Val Thr
100 105 110
Val Ser Ser
115
<210> 1111
<211> 121
<212> PRT
<213> Lama pacos
<400> 1111
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Val Ala Trp
20 25 30
Gln Met Thr Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Arg Ser Phe Gly Val Ser Thr His Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Asn Val Lys Asp Trp Gly Tyr Glu Tyr Glu Gly Tyr Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 1112
<211> 121
<212> PRT
<213> Lama pacos
<400> 1112
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Gln His Glu
20 25 30
Trp Met Glu Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Thr Ser Tyr Gly Tyr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Asn Val Lys Asp Thr Gly Thr Tyr Gln Ala Trp Tyr Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 1113
<211> 121
<212> PRT
<213> Lama pacos
<400> 1113
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Glu Gln Glu
20 25 30
His Met Tyr Trp Tyr Arg Gln Ala Ser Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Val Ser Glu Gly Ala Tyr Thr Ala Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Asn Val Lys Asp Trp Gly Gly Tyr Gln Trp Tyr Tyr Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 1114
<211> 121
<212> PRT
<213> Lama pacos
<400> 1114
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Asn Ala Glu
20 25 30
Ile Met Phe Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Lys Ser Ala Gly Thr Thr Thr Leu Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Asn Val Lys Asp Tyr Gly Ala Gln Ala His Tyr Tyr Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 1115
<211> 121
<212> PRT
<213> Lama pacos
<400> 1115
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Met Trp Ala
20 25 30
His Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Val Ser Ala Gly Ala Tyr Thr His Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Asn Val Lys Asp Trp Gly Thr Tyr Asn Ser Tyr Tyr Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 1116
<211> 115
<212> PRT
<213> Lama pacos
<400> 1116
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Asn Ala Glu
20 25 30
Glu Met Glu Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Ser Ser Ser Gly Asp Trp Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Leu Val Tyr Val Gly Ser Thr Tyr Ile Gly Gln Gly Thr Gln Val Thr
100 105 110
Val Ser Ser
115
<210> 1117
<211> 125
<212> PRT
<213> Lama pacos
<400> 1117
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Ile Gln His Ile Lys
20 25 30
Tyr Leu Gly Trp Phe Arg Gln Ala Pro Gly Arg Glu Arg Glu Gly Val
35 40 45
Ala Ala Leu Met Thr Arg Tyr Gly Gln Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Val Ser Leu Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Ala Ala His Tyr Gly Asp Asn Phe Pro Leu Ala Tyr Gln Ala Tyr
100 105 110
Leu Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120 125
<210> 1118
<211> 125
<212> PRT
<213> Lama pacos
<400> 1118
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ile Asn Gln Ile Tyr
20 25 30
Tyr Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val
35 40 45
Ala Ala Leu Asn Thr Tyr Gln Gly Gln Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Val Ser Leu Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Ala Ala Arg Trp Gly Arg Asp Glu Pro Leu Tyr His Tyr Tyr Tyr
100 105 110
Ser Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120 125
<210> 1119
<211> 121
<212> PRT
<213> Lama pacos
<400> 1119
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Ser Phe Pro Val Asp Thr Tyr
20 25 30
His Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Val Ser Trp Gly Trp Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Asn Val Lys Asp Ile Gly Ala Gln Glu Val His Tyr Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 1120
<211> 125
<212> PRT
<213> Lama pacos
<400> 1120
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ile Lys Ser Ile Lys
20 25 30
Tyr Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val
35 40 45
Ala Ala Leu Met Thr Arg Tyr Gly Glu Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Val Ser Leu Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Ala Ala Asn Tyr Gly Asn Asn Trp Pro Leu Thr Gly Val Asn Tyr
100 105 110
Trp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120 125
<210> 1121
<211> 115
<212> PRT
<213> Lama pacos
<400> 1121
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Lys Ser Tyr
20 25 30
Glu Met Glu Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Ser Ser Tyr Gly Glu Tyr Thr Glu Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Tyr Val Trp Val Gly Asp Ser Tyr Leu Gly Gln Gly Thr Gln Val Thr
100 105 110
Val Ser Ser
115
<210> 1122
<211> 125
<212> PRT
<213> Lama pacos
<400> 1122
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Ile Thr His Ile Val
20 25 30
Tyr Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val
35 40 45
Ala Ala Leu Met Thr Arg Trp Gly Thr Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Val Ser Leu Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Ala Ala Lys Tyr Gly Gln Asn Phe Pro Leu Ser Tyr His Ala Tyr
100 105 110
Arg Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120 125
<210> 1123
<211> 125
<212> PRT
<213> Lama pacos
<400> 1123
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ile Lys His Ile Glu
20 25 30
Tyr Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val
35 40 45
Ala Ala Leu Lys Thr Ser Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Val Ser Leu Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Ala Ala Arg Tyr Gly Arg Ser Asp Pro Leu His Tyr His Glu Tyr
100 105 110
Ser Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120 125
<210> 1124
<211> 125
<212> PRT
<213> Lama pacos
<400> 1124
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ser Ser Ile Thr
20 25 30
Tyr Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val
35 40 45
Ala Ala Leu Val Thr Ser Arg Gly Lys Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Val Ser Leu Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Ala Ala Ser Trp Gly Tyr Thr Trp Pro Leu Tyr Thr Tyr Asp Tyr
100 105 110
Trp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120 125
<210> 1125
<211> 121
<212> PRT
<213> Lama pacos
<400> 1125
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Trp Ala His
20 25 30
His Met Leu Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Ala Ser Trp Gly Ala Asn Thr Ala Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Asn Val Lys Asp Ser Gly Gln Tyr Arg Glu Asn Tyr Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Gln Val Thr Val Ser Ser
115 120
<210> 1126
<211> 115
<212> PRT
<213> Lama pacos
<400> 1126
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Gly Gln Gln
20 25 30
His Met Tyr Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Tyr Ser Tyr Gly His Ile Thr Lys Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Trp Val Tyr Val Gly Asp Tyr Tyr Glu Gly Gln Gly Thr Gln Val Thr
100 105 110
Val Ser Ser
115
<210> 1127
<211> 125
<212> PRT
<213> Lama pacos
<400> 1127
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ala Ile Asn Gln Ile Tyr
20 25 30
Tyr Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val
35 40 45
Ala Ala Leu Ser Thr Lys Tyr Gly Glu Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Val Ser Leu Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Ala Ala Arg Trp Gly Arg Gln Tyr Pro Leu Thr Phe Val Tyr Tyr
100 105 110
Ser Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120 125
<210> 1128
<211> 125
<212> PRT
<213> Lama pacos
<400> 1128
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly His Ile Ala Gln Ile Glu
20 25 30
Tyr Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val
35 40 45
Ala Ala Leu Ser Thr Asn Gln Gly Tyr Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Val Ser Leu Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Ala Ala Arg Trp Gly Arg Thr Tyr Pro Leu Ser Tyr Met Ala Tyr
100 105 110
Thr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120 125
<210> 1129
<211> 125
<212> PRT
<213> Lama pacos
<400> 1129
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ile Thr Met Ile Glu
20 25 30
Tyr Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val
35 40 45
Ala Ala Leu Asn Thr His Thr Gly Gly Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Val Ser Leu Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Ala Ala Arg Trp Gly Arg Tyr Glu Pro Leu His Tyr Ala Tyr Tyr
100 105 110
Ser Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120 125
<210> 1130
<211> 125
<212> PRT
<213> Lama pacos
<400> 1130
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Ile Tyr Asn Ile Lys
20 25 30
Tyr Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val
35 40 45
Ala Ala Leu Met Thr Arg Tyr Gly Glu Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Val Ser Leu Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Ala Ala Ser Tyr Gly Ala Asn Trp Pro Leu Val Ser Ala Ala Tyr
100 105 110
Thr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120 125
<210> 1131
<211> 126
<212> PRT
<213> Lama pacos
<400> 1131
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ala Ile Ser Thr Ile Glu
20 25 30
Tyr Leu Gly Trp Phe Arg Gln Ala Pro Gly Arg Glu Arg Glu Gly Val
35 40 45
Ala Ala Leu Tyr Thr Glu Arg Gly Tyr Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Val Ser Leu Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Ala Ala Arg Tyr Gly His Ala Gln Ala Pro Leu His Tyr Phe Trp
100 105 110
Tyr Gly Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120 125
<210> 1132
<211> 115
<212> PRT
<213> Lama pacos
<400> 1132
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Ala Ala Tyr
20 25 30
Glu Met Glu Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Asn Ser Met Gly Asp Gln Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Tyr Val Tyr Val Gly Phe Ser Tyr Ile Gly Gln Gly Thr Gln Val Thr
100 105 110
Val Ser Ser
115
<210> 1133
<211> 115
<212> PRT
<213> Lama pacos
<400> 1133
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Asp Tyr Met
20 25 30
Glu Met Glu Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Thr Ser Asn Gly Arg Glu Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Tyr Val Tyr Val Gly Ser Ser Tyr Ile Gly Gln Gly Thr Gln Val Thr
100 105 110
Val Ser Ser
115
<210> 1134
<211> 115
<212> PRT
<213> Lama pacos
<400> 1134
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Trp Phe Gln
20 25 30
Glu Met Glu Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Ser Ser Gln Gly Thr His Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Tyr Val Tyr Val Gly Ala Ser Tyr Leu Gly Gln Gly Thr Gln Val Thr
100 105 110
Val Ser Ser
115
<210> 1135
<211> 115
<212> PRT
<213> Lama pacos
<400> 1135
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Trp Gln Gly
20 25 30
Glu Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Ser Ser Met Gly Tyr Lys Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Val Met Val Gly Phe Trp Tyr Ala Gly Gln Gly Thr Gln Val Thr
100 105 110
Val Ser Ser
115
<210> 1136
<211> 117
<212> PRT
<213> Lama pacos
<400> 1136
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Gly Gly Phe Pro Val Lys Asp His
20 25 30
Glu Met Glu Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Thr Ser Ser Gly Trp Gly Thr Asn Thr Tyr Tyr Ala Asp
50 55 60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr
65 70 75 80
Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr
85 90 95
Tyr Cys Tyr Val Tyr Val Gly Ser Ser Tyr Ile Gly Gln Gly Thr Gln
100 105 110
Val Thr Val Ser Ser
115
<210> 1137
<211> 115
<212> PRT
<213> Lama pacos
<400> 1137
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Asn Gln Glu
20 25 30
Glu Met Glu Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Lys Ser Trp Gly Thr Leu Thr Ala Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Val His Val Gly Gln Thr Tyr Ile Gly Gln Gly Thr Gln Val Thr
100 105 110
Val Ser Ser
115
<210> 1138
<211> 115
<212> PRT
<213> Lama pacos
<400> 1138
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Tyr Ser Trp
20 25 30
Asn Met Trp Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Glu Ser His Gly Asp Ser Thr Arg Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Tyr Val Trp Val Gly His Thr Tyr Tyr Gly Gln Gly Thr Gln Val Thr
100 105 110
Val Ser Ser
115
<210> 1139
<211> 115
<212> PRT
<213> Lama pacos
<400> 1139
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Arg Cys Ala Ala Ser Gly Phe Pro Val Glu Thr Thr
20 25 30
Glu Met Glu Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Ser Ser Tyr Gly Ser Glu Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Tyr Val Tyr Val Gly Thr Ser Tyr Leu Gly Gln Gly Thr Gln Val Thr
100 105 110
Val Ser Ser
115
<210> 1140
<211> 114
<212> PRT
<213> Lama pacos
<400> 1140
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Trp Ser Asn
20 25 30
Glu Met Glu Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val
35 40 45
Ala Ala Ile Thr Ser Tyr Gly Thr Thr Glu Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Tyr
85 90 95
Val Tyr Val Gly Tyr Ser Tyr Ile Gly Gln Gly Thr Gln Val Thr Val
100 105 110
Ser Ser
<210> 1141
<211> 118
<212> PRT
<213> Lama pacos
<400> 1141
Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Val
20 25 30
Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val
35 40 45
Ser Arg Ile Ser Pro Asn Ser Gly Asn Ile Gly Tyr Thr Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Ile Gly Leu Asn Leu Ser Ser Ser Ser Val Arg Gly Gln Gly Thr
100 105 110
Gln Val Thr Val Ser Ser
115
<210> 1142
<211> 125
<212> PRT
<213> Lama pacos
<400> 1142
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Glu Tyr
20 25 30
Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val
35 40 45
Ala Thr Ile Ser Trp Ser Gly Gly Ser Thr Tyr Tyr Thr Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ala Ala Gly Leu Gly Thr Val Val Ser Glu Trp Asp Tyr Asp Tyr
100 105 110
Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
115 120 125
<210> 1143
<211> 119
<212> PRT
<213> Lama pacos
<400> 1143
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Glu
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Ile Phe Gly Ile Ala
20 25 30
Ala Val His Trp Phe Arg Lys Ala Pro Gly Lys Glu Arg Glu Phe Thr
35 40 45
Ala Gly Phe Gly Ser Asp Gly Ser Thr Asn Tyr Ala Asn Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Thr Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys His
85 90 95
Ala Leu Ile Lys Asn Glu Leu Gly Phe Leu Asp Tyr Trp Gly Pro Gly
100 105 110
Thr Gln Val Thr Val Ser Ser
115
<210> 1144
<211> 119
<212> PRT
<213> Lama pacos
<400> 1144
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Glu
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Gly Ile Tyr
20 25 30
Ala Val His Trp Phe Arg Met Ala Pro Gly Lys Glu Arg Glu Phe Thr
35 40 45
Ala Gly Phe Gly Ser His Gly Ser Thr Asn Tyr Ala Ala Ser Val Lys
50 55 60
Gly Arg Phe Thr Met Ser Arg Asp Asn Ala Lys Asn Thr Thr Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Lys Pro Ala Asp Thr Ala Val Tyr Tyr Cys His
85 90 95
Ala Leu Ile Lys Asn Glu Leu Gly Phe Leu Asp Tyr Trp Gly Pro Gly
100 105 110
Thr Gln Val Thr Val Ser Ser
115
<210> 1145
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1145
Glu Ile Val Met Thr Gln Ser His Thr Leu Leu Pro Val Thr Pro Gly
1 5 10 15
Glu Pro Ala Ser Ile Thr Cys Arg Ser Ser Gln Ser Leu Leu His Ser
20 25 30
Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala
85 90 95
Leu Gln Thr Pro Gln Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys
100 105 110
<210> 1146
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1146
Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Glu
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Lys Trp Pro Pro
85 90 95
Trp Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys
100 105
<210> 1147
<211> 113
<212> PRT
<213> Homo sapiens
<400> 1147
Glu Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Glu Arg Ala Thr Ile Asn Cys Arg Ser Ser Gln Ser Val Leu Tyr Ser
20 25 30
Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
35 40 45
Pro Pro Lys Val Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln
85 90 95
Tyr Tyr Ser Ser Pro Tyr Ala Phe Gly Pro Gly Thr Lys Val Asp Ile
100 105 110
Lys
<210> 1148
<211> 113
<212> PRT
<213> Homo sapiens
<400> 1148
Glu Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser
20 25 30
Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
35 40 45
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys His Gln
85 90 95
Tyr Tyr Asn Thr Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile
100 105 110
Lys
<210> 1149
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1149
Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Ala Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Arg Gln Arg Ser Asn Trp Pro Pro
85 90 95
Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys
100 105
<210> 1150
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1150
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Glu Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys
100 105
<210> 1151
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1151
Asp Ile Gln Met Thr His Ser Leu Ile Leu Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Ala Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Tyr Arg Pro Pro Trp
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys
100 105
<210> 1152
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1152
Glu Ile Val Val Thr Gln Ser Leu Leu Ser Leu Pro Val Thr Pro Gly
1 5 10 15
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser
20 25 30
Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Gln Val Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Thr
85 90 95
Leu Gln Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105 110
<210> 1153
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1153
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Leu
85 90 95
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1154
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1154
Glu Ile Val Met Thr Gln Ser Pro Leu Ser Ser Pro Val Thr Leu Gly
1 5 10 15
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser
20 25 30
Asp Gly Asn Thr Tyr Leu Ser Trp Leu Gln Gln Arg Pro Gly Gln Pro
35 40 45
Pro Arg Leu Leu Ile Tyr Lys Ile Ser Asn Arg Phe Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ala Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala
85 90 95
Thr Gln Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys
100 105 110
<210> 1155
<211> 113
<212> PRT
<213> Homo sapiens
<400> 1155
Asp Ile Val Met Thr His Ser Leu Arg Leu Leu Ala Val Ser Leu Gly
1 5 10 15
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser
20 25 30
Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
35 40 45
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln
85 90 95
Tyr Tyr Ser Thr Tyr Gly Ser Phe Gly Gly Gly Thr Lys Val Asp Ile
100 105 110
Lys
<210> 1156
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1156
Gln Ala Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln
1 5 10 15
Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn
20 25 30
Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln
65 70 75 80
Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu
85 90 95
Ser Val Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1157
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1157
Gln Ala Val Val Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn
20 25 30
Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu
85 90 95
Asn Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1158
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1158
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Arg
1 5 10 15
Asn Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Lys Asn Asp
20 25 30
Leu Cys Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Asn Tyr Pro Leu
85 90 95
Thr Phe Gly Gly Gly Thr Asn Glu Glu Ile Lys
100 105
<210> 1159
<211> 109
<212> PRT
<213> Mus musculus
<400> 1159
Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu
1 5 10 15
Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser
20 25 30
Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly
35 40 45
Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe
50 55 60
Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala
65 70 75 80
Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn
85 90 95
His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1160
<211> 107
<212> PRT
<213> Mus musculus
<400> 1160
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly
1 5 10 15
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile
35 40 45
Phe Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln
65 70 75 80
Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1161
<211> 106
<212> PRT
<213> Mus musculus
<400> 1161
Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly
1 5 10 15
Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Phe
20 25 30
Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile
35 40 45
Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Asp Tyr
65 70 75 80
Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Arg Thr
85 90 95
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1162
<211> 109
<212> PRT
<213> Mus musculus
<400> 1162
Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu
1 5 10 15
Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser
20 25 30
Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Ile Thr Gly
35 40 45
Leu Ile Gly Gly Thr Asn Asn Arg Val Pro Gly Val Pro Ala Arg Phe
50 55 60
Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala
65 70 75 80
Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn
85 90 95
Gln Phe Ile Phe Gly Ser Gly Thr Lys Val Thr Val Leu
100 105
<210> 1163
<211> 109
<212> PRT
<213> Mus musculus
<400> 1163
Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu
1 5 10 15
Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser
20 25 30
Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly
35 40 45
Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe
50 55 60
Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala
65 70 75 80
Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn
85 90 95
His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1164
<211> 111
<212> PRT
<213> Mus musculus
<400> 1164
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr
20 25 30
Gly Thr Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
35 40 45
Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala
50 55 60
Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp
65 70 75 80
Pro Val Glu Ala Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Asn Asn
85 90 95
Glu Asp Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105 110
<210> 1165
<211> 112
<212> PRT
<213> Mus musculus
<400> 1165
Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly
1 5 10 15
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser
20 25 30
Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly
85 90 95
Ser His Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 1166
<211> 111
<212> PRT
<213> Mus musculus
<400> 1166
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Gly Val Asp Ser Tyr
20 25 30
Gly Ser Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
35 40 45
Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala
50 55 60
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp
65 70 75 80
Pro Val Glu Ala Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Asn Asn
85 90 95
Glu Asp Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105 110
<210> 1167
<211> 106
<212> PRT
<213> Mus musculus
<400> 1167
Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly
1 5 10 15
Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Phe
20 25 30
Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile
35 40 45
Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr
65 70 75 80
Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Arg Thr
85 90 95
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1168
<211> 109
<212> PRT
<213> Mus musculus
<400> 1168
Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu
1 5 10 15
Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser
20 25 30
Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Ile Thr Gly
35 40 45
Leu Ile Gly Gly Thr Asn Asn Arg Val Pro Gly Val Pro Ala Arg Phe
50 55 60
Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala
65 70 75 80
Gln Thr Glu Asp Lys Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn
85 90 95
Gln Phe Ile Phe Gly Ser Gly Thr Lys Val Thr Val Leu
100 105
<210> 1169
<211> 111
<212> PRT
<213> Mus musculus
<400> 1169
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Gly Val Asp Ser Tyr
20 25 30
Gly Ser Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro
35 40 45
Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala
50 55 60
Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp
65 70 75 80
Pro Val Glu Ala Asp Asp Ala Ala Ile Tyr Tyr Cys Gln Gln Asn Asn
85 90 95
Glu Asp Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 1170
<211> 111
<212> PRT
<213> Mus musculus
<400> 1170
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Glu Tyr Tyr
20 25 30
Gly Thr Ser Leu Met Gln Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro
35 40 45
Lys Leu Leu Ile Phe Ala Ala Ser Asn Val Glu Ser Gly Val Pro Ala
50 55 60
Arg Phe Gly Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His
65 70 75 80
Pro Val Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys Gln Gln Ser Arg
85 90 95
Lys Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 1171
<211> 106
<212> PRT
<213> Mus musculus
<400> 1171
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
1 5 10 15
Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
20 25 30
His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr
35 40 45
Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu
65 70 75 80
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr
85 90 95
Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1172
<211> 111
<212> PRT
<213> Mus musculus
<400> 1172
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Glu Tyr Tyr
20 25 30
Gly Thr Ser Leu Met Gln Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro
35 40 45
Lys Leu Leu Ile Phe Ala Ala Ser Asn Val Glu Ser Gly Val Pro Ala
50 55 60
Arg Phe Gly Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His
65 70 75 80
Pro Val Glu Glu Asp Asp Ile Ala Thr Tyr Phe Cys Gln Gln Ser Arg
85 90 95
Lys Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 1173
<211> 109
<212> PRT
<213> Mus musculus
<400> 1173
Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu
1 5 10 15
Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser
20 25 30
Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly
35 40 45
Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe
50 55 60
Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala
65 70 75 80
Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn
85 90 95
His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1174
<211> 110
<212> PRT
<213> Mus musculus
<400> 1174
Gln Ala Val Val Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn
20 25 30
Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Asn Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg
65 70 75 80
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu
85 90 95
Ile Tyr Val Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1175
<211> 109
<212> PRT
<213> Mus musculus
<400> 1175
Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu
1 5 10 15
Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser
20 25 30
Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly
35 40 45
Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe
50 55 60
Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala
65 70 75 80
Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Asn Asn
85 90 95
His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1176
<211> 106
<212> PRT
<213> Mus musculus
<400> 1176
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
1 5 10 15
Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
20 25 30
Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Leu Leu Ile Tyr
35 40 45
Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Ile Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu
65 70 75 80
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro Leu Thr
85 90 95
Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105
<210> 1177
<211> 112
<212> PRT
<213> Mus musculus
<400> 1177
Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly
1 5 10 15
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val Tyr Ser
20 25 30
Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Gly Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly
85 90 95
Ser His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 1178
<211> 111
<212> PRT
<213> Mus musculus
<400> 1178
Asp Ile Val Leu Thr Gln Ser Gln Ala Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Glu Tyr Tyr
20 25 30
Gly Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
35 40 45
Lys Leu Leu Ile Tyr Ala Ala Ser Asn Val Glu Ser Gly Val Pro Ala
50 55 60
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His
65 70 75 80
Pro Val Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys Gln Gln Ser Arg
85 90 95
Lys Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 1179
<211> 106
<212> PRT
<213> Mus musculus
<400> 1179
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
1 5 10 15
Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
20 25 30
Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Leu Leu Ile Tyr
35 40 45
Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Ile Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu
65 70 75 80
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro Leu Thr
85 90 95
Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105
<210> 1180
<211> 111
<212> PRT
<213> Mus musculus
<400> 1180
Asp Ile Val Leu Thr Gln Ser Gln Ala Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Glu Tyr Tyr
20 25 30
Gly Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
35 40 45
Lys Leu Leu Ile Tyr Ala Ala Ser Asn Val Glu Ser Gly Val Pro Ala
50 55 60
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His
65 70 75 80
Pro Val Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys Gln Gln Ser Arg
85 90 95
Lys Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 1181
<211> 111
<212> PRT
<213> Mus musculus
<400> 1181
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr
20 25 30
Gly Ile Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro
35 40 45
Lys Leu Leu Ile Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ala
50 55 60
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His
65 70 75 80
Pro Met Glu Glu Asp Asp Thr Ala Met Tyr Phe Phe Gln Gln Ser Lys
85 90 95
Glu Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 1182
<211> 111
<212> PRT
<213> Mus musculus
<400> 1182
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Thr Val Ser Leu Gly
1 5 10 15
Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Gly
20 25 30
Gly Asp Arg Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
35 40 45
Lys Leu Leu Ile Phe Ala Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala
50 55 60
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His
65 70 75 80
Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Asn
85 90 95
Glu Asp Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 1183
<211> 111
<212> PRT
<213> Mus musculus
<400> 1183
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Gln Arg Ala Thr Met Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr
20 25 30
Gly Asn Gly Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
35 40 45
Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala
50 55 60
Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Ser Leu Thr Ile Asp
65 70 75 80
Pro Val Glu Ala Asp Asp Ala Ala Ile Tyr Tyr Cys Gln Gln Asn Asn
85 90 95
Glu Asp Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105 110
<210> 1184
<211> 107
<212> PRT
<213> Mus musculus
<400> 1184
Asp Ile Val Leu Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly
1 5 10 15
Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Asn Ile Gly Thr Ile
20 25 30
Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile
35 40 45
Lys Tyr Ala Ser Glu Ser Val Ser Gly Ile Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser
65 70 75 80
Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Ser Ser Ser Trp Pro Leu
85 90 95
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105
<210> 1185
<211> 107
<212> PRT
<213> Mus musculus
<400> 1185
Asp Ile Val Leu Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly
1 5 10 15
Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Asn Ile Gly Thr Ile
20 25 30
Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile
35 40 45
Lys Tyr Ala Ser Glu Ser Val Ser Gly Ile Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser
65 70 75 80
Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Ser Ser Ser Trp Pro Leu
85 90 95
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105
<210> 1186
<211> 111
<212> PRT
<213> Homo sapiens
<400> 1186
Gln Ser Ala Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys
1 5 10 15
Thr Val Thr Ile Ser Cys Thr Gly Ser Ser Gly Ser Ile Ala Ser Asn
20 25 30
Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ala Pro Thr Thr Val
35 40 45
Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly
65 70 75 80
Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser
85 90 95
Ser Asn His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1187
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1187
Ala Ile Arg Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Thr Gly Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Ser Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Arg
85 90 95
Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1188
<211> 113
<212> PRT
<213> Homo sapiens
<400> 1188
Ala Ile Arg Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser
20 25 30
Pro Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
35 40 45
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln
85 90 95
Tyr Tyr Ser Thr Pro Phe Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile
100 105 110
Lys
<210> 1189
<211> 109
<212> PRT
<213> Homo sapiens
<400> 1189
Glu Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser
20 25 30
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
35 40 45
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65 70 75 80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Arg
85 90 95
Ser Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1190
<211> 109
<212> PRT
<213> Homo sapiens
<400> 1190
Ala Ile Arg Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Phe Thr
85 90 95
Leu Tyr Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys
100 105
<210> 1191
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1191
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Ser Ile Thr Cys Arg Ala Ser Gln Asn Ile Ser Asn Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Glu Ala Pro Lys Leu Leu Ile
35 40 45
Ser Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Gly Gly
50 55 60
Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Asn Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser His Ser Phe Pro Phe
85 90 95
Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys
100 105
<210> 1192
<211> 106
<212> PRT
<213> Homo sapiens
<400> 1192
Ala Ile Arg Met Thr Gln Ser Pro Ser Phe Leu Ser Val Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Ser Tyr Val Thr
85 90 95
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1193
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1193
Gln Ser Val Leu Thr Gln Leu Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Thr Val Thr Ile Ser Cys Ser Gly Asn Val Phe Lys Glu Lys Ser Asn
20 25 30
Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Arg Asn Asn His Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Lys Ser Gly Thr Ser Pro Ser Leu Ala Ile Ser Gly Leu Arg
65 70 75 80
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Arg Asp Asp Ser Leu
85 90 95
Ser Gly Trp Val Phe Ser Gly Arg Thr Lys Leu Thr Val Leu
100 105 110
<210> 1194
<211> 106
<212> PRT
<213> Homo sapiens
<400> 1194
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Ser
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Arg Ala Thr Gly Val Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro
65 70 75 80
Asp Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Thr Asn Trp Pro Leu
85 90 95
Phe Gly Pro Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1195
<211> 106
<212> PRT
<213> Homo sapiens
<400> 1195
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Ala Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr
20 25 30
Leu Ile Trp Cys His Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Thr Leu Gln Thr Gly Val Pro Ser Arg Phe Ile Gly
50 55 60
Gly Gly Ser Gly Thr Asn Phe Thr Leu Thr Ile Ile Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Ala Tyr Tyr Cys Gln Gln Asn Tyr Ser Thr Trp Thr
85 90 95
Ile Gly Gln Gly Ser Arg Val Glu Met Lys
100 105
<210> 1196
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1196
Gln Ser Val Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Met Tyr
20 25 30
Asn Leu Val Ser Trp Tyr Gln Gln His Pro Gly Gln Ala Pro Lys Leu
35 40 45
Met Ile Tyr Glu Gly Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Tyr Tyr Tyr Cys Cys Ser Tyr Ala Val Ser
85 90 95
Ser Thr Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1197
<211> 109
<212> PRT
<213> Homo sapiens
<400> 1197
Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Asn Phe
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro
85 90 95
Ala Phe Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1198
<211> 109
<212> PRT
<213> Homo sapiens
<400> 1198
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro
85 90 95
Lys Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys
100 105
<210> 1199
<211> 113
<212> PRT
<213> Homo sapiens
<400> 1199
Asp Ile Gln Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Glu Arg Ala Thr Ile Lys Cys Lys Ser Ser Gln Ser Val Leu His Ser
20 25 30
Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Ala Gly Gln
35 40 45
Pro Pro Ser Leu Leu Leu Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln
85 90 95
Tyr Tyr Asn Asn Gln Trp Thr Phe Gly Gln Gly Thr Lys Val Asp Ile
100 105 110
Lys
<210> 1200
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1200
Ala Ile Arg Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Ser Cys Arg Ala Thr Gln Asn Ile Asn Tyr Phe
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Arg Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Gly Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Thr Gly Arg Val Phe Thr Leu Thr Ile Asn Ser Leu Gln Pro
65 70 75 80
Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Phe Val Ser Pro Arg
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys
100 105
<210> 1201
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1201
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Phe Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Asp Ile Gly Gly Asp
20 25 30
Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Glu Arg Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Ala Thr Glu Phe Ala Leu Thr Ile Thr Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Lys Ser Tyr Pro Leu
85 90 95
Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys
100 105
<210> 1202
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1202
Glu Ile Val Met Thr Gln Ser Pro Leu Ser Ser Pro Val Thr Leu Gly
1 5 10 15
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser
20 25 30
Asp Gly Asn Thr Tyr Leu Ser Trp Leu Gln Gln Arg Pro Gly Gln Pro
35 40 45
Pro Arg Leu Leu Ile Tyr Lys Ile Ser Asn Arg Phe Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ala Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Thr Gln Ala
85 90 95
Thr Gln Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys
100 105 110
<210> 1203
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1203
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp
20 25 30
Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser Tyr Pro Leu
85 90 95
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1204
<211> 106
<212> PRT
<213> Homo sapiens
<400> 1204
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
1 5 10 15
Thr Ala Ser Ile Thr Cys Ser Gly Asp Lys Leu Gly Asp Lys Tyr Ala
20 25 30
Cys Trp Tyr Arg Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr
35 40 45
Gln Asp Ser Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Ser Thr Gly Val
85 90 95
Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1205
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1205
Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Ala Ser Pro Gly
1 5 10 15
Glu Arg Val Thr Leu Ser Cys Arg Ala Ser Gln Asn Ile Arg Asn Asn
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
His Gly Ala Ser Thr Arg Ala Ala Gly Ala Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Asp Thr Gln Phe Thr Leu Thr Val Ser Ser Leu Gln Ser
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Tyr Ser Lys Trp Pro Val
85 90 95
Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys
100 105
<210> 1206
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1206
Asp Ile Val Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Ser Tyr Pro Pro
85 90 95
Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1207
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1207
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr
85 90 95
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1208
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1208
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Arg
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1209
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1209
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Thr
20 25 30
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
35 40 45
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65 70 75 80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro
85 90 95
Arg Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1210
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1210
Ala Ile Arg Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Ile
85 90 95
Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys
100 105
<210> 1211
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1211
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Ser Ser
20 25 30
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
35 40 45
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65 70 75 80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro
85 90 95
Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1212
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1212
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Arg Val Thr Val Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn
20 25 30
Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp Glu Ala Asp Tyr Phe Cys Ala Ala Trp Asp Asp Ser Leu
85 90 95
Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1213
<211> 106
<212> PRT
<213> Homo sapiens
<400> 1213
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Asn Gln Ser Ile Ser Ser Trp
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Trp Thr
85 90 95
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1214
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1214
Gln Ser Ala Leu Thr Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr
20 25 30
Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Met Ile Tyr Glu Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Glu Tyr Tyr Cys Ser Ser Asp Ala Gly Ser
85 90 95
Asn Asn Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1215
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1215
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Thr Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro
85 90 95
Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1216
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1216
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Leu
85 90 95
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1217
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1217
Ala Ile Arg Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Asn Ser Leu Gln Pro
65 70 75 80
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Pro
85 90 95
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1218
<211> 103
<212> PRT
<213> Homo sapiens
<400> 1218
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ile Thr Phe Gly Gln
85 90 95
Gly Thr Arg Leu Glu Ile Lys
100
<210> 1219
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1219
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Arg Ser Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro
85 90 95
Ala Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1220
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1220
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys
1 5 10 15
Thr Ala Arg Ile Thr Cys Gly Glu Asn Asn Ile Gly Ser Lys Ser Val
20 25 30
His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr
35 40 45
Tyr Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Asn Arg Val Glu Ala Gly
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp His
85 90 95
Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1221
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1221
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly
1 5 10 15
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser
20 25 30
Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala
85 90 95
Leu Gln Thr Pro Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys
100 105 110
<210> 1222
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1222
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Ser Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Asn Tyr Arg Tyr
85 90 95
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1223
<211> 106
<212> PRT
<213> Homo sapiens
<400> 1223
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Ser Thr
85 90 95
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1224
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1224
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly
1 5 10 15
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser
20 25 30
Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala
85 90 95
Leu Gln Thr Pro His Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105 110
<210> 1225
<211> 106
<212> PRT
<213> Homo sapiens
<400> 1225
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Ser Thr
85 90 95
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1226
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1226
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro
85 90 95
Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1227
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1227
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser
20 25 30
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
35 40 45
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Gly Gly Ser Glu Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65 70 75 80
Pro Glu Asp Cys Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro
85 90 95
Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1228
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1228
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser
20 25 30
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
35 40 45
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65 70 75 80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro
85 90 95
Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1229
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1229
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Val Thr Ala Asn
20 25 30
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
35 40 45
Ile Tyr Gly Ala Ser Lys Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Ser Arg Leu Glu
65 70 75 80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Thr Thr Thr Pro
85 90 95
Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1230
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1230
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Val Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Trp Ala Ser Gln Ser Val Ser Ala Ser
20 25 30
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
35 40 45
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65 70 75 80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Thr Thr Pro
85 90 95
Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1231
<211> 111
<212> PRT
<213> Homo sapiens
<400> 1231
Gln Ser Ala Leu Thr Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr
20 25 30
Lys Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Met Ile Tyr Glu Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Glu Gly Ser
85 90 95
Asn Asn Phe Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1232
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1232
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys
1 5 10 15
Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val
20 25 30
His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr
35 40 45
Phe Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Arg Asp His
85 90 95
Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1233
<211> 111
<212> PRT
<213> Homo sapiens
<400> 1233
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn
20 25 30
Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg
65 70 75 80
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu
85 90 95
Ser Gly Phe Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1234
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1234
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr
20 25 30
Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Tyr Thr Ser Ser
85 90 95
Ser Thr Arg Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 1235
<211> 111
<212> PRT
<213> Homo sapiens
<400> 1235
Gln Ser Ala Leu Thr Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr
20 25 30
Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Met Ile Tyr Glu Val Thr Lys Arg Pro Ser Gly Val Pro Asp Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ala Gly Ser
85 90 95
Asn Asn Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1236
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1236
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Tyr Trp
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Gln Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Glu Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr
85 90 95
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1237
<211> 111
<212> PRT
<213> Homo sapiens
<400> 1237
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln
1 5 10 15
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn
20 25 30
Ala Val Asn Trp Tyr Gln Gln Val Pro Gly Lys Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Tyr Asp Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser
50 55 60
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu
85 90 95
Asn Gly Ala Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1238
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1238
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr
20 25 30
Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser
85 90 95
Ser Thr Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1239
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1239
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Met Ser Ser Trp
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Asn Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Asn Ser Ser Pro Leu
85 90 95
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1240
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1240
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln
1 5 10 15
Arg Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asn Ile Gly Ala Gly
20 25 30
Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Arg Ala Pro Lys Val
35 40 45
Leu Ile Ser Gly Asn Asn Ile Arg Pro Ser Glu Val Pro Asp Arg Phe
50 55 60
Ser Gly Ser Arg Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Ser Leu
65 70 75 80
Gln Pro Glu Asp Glu Ala Gln Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser
85 90 95
Leu Tyr Ala Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1241
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1241
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Ser Val Thr Pro Gly
1 5 10 15
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser
20 25 30
Asn Gly Asn Asn Tyr Phe Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Val
85 90 95
Leu Gln Ile Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 1242
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1242
Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys
1 5 10 15
Thr Val Thr Ile Ser Cys Thr Gly Ser Ser Gly Ser Ile Ala Ser Asn
20 25 30
Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ala Pro Thr Thr Val
35 40 45
Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Ile Asp Arg Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly
65 70 75 80
Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser
85 90 95
Gly Asn His Trp Val Val Phe Gly Gly Gly Thr Arg Leu Thr Val Leu
100 105 110
<210> 1243
<211> 113
<212> PRT
<213> Homo sapiens
<400> 1243
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln
1 5 10 15
Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn
20 25 30
Leu Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Glu Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln
65 70 75 80
Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Trp Asp Ser Ser Leu
85 90 95
Ser Ala Gly Gly Val Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val
100 105 110
Leu
<210> 1244
<211> 111
<212> PRT
<213> Homo sapiens
<400> 1244
Gln Pro Val Leu Thr Gln Ser Pro Ser Ala Ser Ala Ser Leu Gly Ala
1 5 10 15
Ser Val Lys Leu Thr Cys Thr Leu Ser Ser Gly His Ser Ser Tyr Ala
20 25 30
Ile Ala Trp His Gln Gln Gln Pro Glu Lys Gly Pro Arg Tyr Leu Met
35 40 45
Lys Leu Asn Thr Asp Gly Ser His Ser Lys Gly Asp Gly Ile Pro Asp
50 55 60
Arg Phe Ser Gly Ser Ser Ser Gly Ala Glu Arg Tyr Leu Thr Ile Ser
65 70 75 80
Ser Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Thr Trp Gly
85 90 95
Thr Gly Ile Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1245
<211> 111
<212> PRT
<213> Homo sapiens
<400> 1245
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr
20 25 30
Lys Tyr Val Ser Trp Tyr Gln Arg His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser
85 90 95
Ser Thr Ser Val Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu
100 105 110
<210> 1246
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1246
Ala Ile Arg Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Thr Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Lys Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Gln
85 90 95
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1247
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1247
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr
20 25 30
Asn Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Met Ile Tyr Glu Gly Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Ser
85 90 95
Ser Thr Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1248
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1248
Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Ser Asp Ser Tyr
85 90 95
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1249
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1249
Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Ser Tyr Pro Pro
85 90 95
Ala Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys
100 105
<210> 1250
<211> 109
<212> PRT
<213> Homo sapiens
<400> 1250
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Phe Ser Ser Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Asn Asn Trp Pro Pro
85 90 95
Glu Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1251
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1251
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser
20 25 30
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
35 40 45
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65 70 75 80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro
85 90 95
Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1252
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1252
Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys
1 5 10 15
Thr Val Thr Ile Ser Cys Thr Gly Ser Ser Gly Ser Ile Ala Ser Asn
20 25 30
Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ala Pro Thr Thr Val
35 40 45
Ile Asn Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly
65 70 75 80
Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser
85 90 95
Ser Asn Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1253
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1253
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn
20 25 30
Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu
85 90 95
Asn Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1254
<211> 109
<212> PRT
<213> Homo sapiens
<400> 1254
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Asn Ser Arg
20 25 30
Gln Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
35 40 45
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Glu Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65 70 75 80
Ser Glu Asp Phe Ala Val Tyr His Cys Gln Gln Tyr Gly Ser Ser Arg
85 90 95
Ala Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1255
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1255
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys
1 5 10 15
Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val
20 25 30
His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr
35 40 45
Tyr Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp His
85 90 95
Pro Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1256
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1256
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Ile
85 90 95
Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys
100 105
<210> 1257
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1257
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr
20 25 30
Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser
85 90 95
Ser Thr Leu Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1258
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1258
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro
85 90 95
Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1259
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1259
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys
1 5 10 15
Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val
20 25 30
His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr
35 40 45
Tyr Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly
65 70 75 80
Asp Glu Ala Glu Tyr His Cys Gln Val Trp Asp Ser Ser Ser Asp Arg
85 90 95
Pro Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1260
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1260
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asn Trp
20 25 30
Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Glu Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Trp
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1261
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1261
Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys
1 5 10 15
Thr Val Thr Ile Ser Cys Thr Gly Ser Ser Gly Ser Ile Ala Ser Asn
20 25 30
Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ala Pro Thr Thr Val
35 40 45
Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly
65 70 75 80
Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser
85 90 95
Ser Asn Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1262
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1262
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Leu
85 90 95
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1263
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1263
Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Ser Tyr Ser Tyr
85 90 95
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1264
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1264
Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys
1 5 10 15
Thr Val Thr Ile Ser Cys Thr Gly Ser Ser Gly Ser Ile Ala Ser Asn
20 25 30
Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ala Pro Thr Thr Val
35 40 45
Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly
65 70 75 80
Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser
85 90 95
Ser Asn Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1265
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1265
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Asn Asp Val Gly Ser Tyr
20 25 30
Thr Leu Val Ser Trp Tyr Gln Gln Tyr Pro Gly Lys Ala Pro Lys Leu
35 40 45
Leu Ile Phe Glu Gly Thr Lys Arg Ser Ser Gly Ile Ser Asn Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Gly Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Ala
85 90 95
Ser Thr Phe Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1266
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1266
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr
20 25 30
Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser
85 90 95
Ser Thr Arg Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 1267
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1267
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr
20 25 30
Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser
85 90 95
Thr Thr Arg Val Phe Gly Thr Gly Thr Arg Val Thr Val Leu
100 105 110
<210> 1268
<211> 111
<212> PRT
<213> Homo sapiens
<400> 1268
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Ile Gly Val Tyr
20 25 30
Asn Tyr Ile Ser Trp Ser Gln Gln His Pro Gly Lys Ala Pro Lys Val
35 40 45
Met Ile Tyr Asp Val Thr Asn Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Arg Gly Ser
85 90 95
Ser Thr Pro Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 1269
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1269
Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly
1 5 10 15
Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly
20 25 30
His Tyr Pro Tyr Trp Phe Gln Gln Lys Ser Gly Gln Ala Pro Arg Thr
35 40 45
Leu Ile Tyr Glu Thr Ser Ile Lys His Ser Trp Thr Pro Ala Arg Phe
50 55 60
Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Ala
65 70 75 80
Gln Pro Glu Asp Glu Ala Asp Tyr Tyr Cys Leu Leu Ser Tyr Ser Gly
85 90 95
Ala Arg Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1270
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1270
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser His
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Thr Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Pro
85 90 95
Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1271
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1271
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Tyr Tyr
20 25 30
Asn Phe Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Met Ile Tyr Glu Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Ile Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Arg Ser Ser
85 90 95
Ser Thr Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1272
<211> 111
<212> PRT
<213> Homo sapiens
<400> 1272
Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys
1 5 10 15
Thr Val Thr Ile Ser Cys Thr Gly Ser Ser Gly Ser Ile Ala Ser Asn
20 25 30
Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ala Pro Thr Thr Val
35 40 45
Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly
65 70 75 80
Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser
85 90 95
Ser Asn Tyr Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1273
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1273
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr
20 25 30
Asn Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Met Ile Tyr Glu Gly Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Ser
85 90 95
Ser Thr Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1274
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1274
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Gly Ile Ser Asn Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Ile
85 90 95
Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys
100 105
<210> 1275
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1275
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Gly Ala Ser Thr Arg Ala Thr Ala Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Arg
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1276
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1276
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln
1 5 10 15
Thr Ala Arg Ile Ser Cys Gly Gly Asn Asn Ile Gly Ser Lys Asn Val
20 25 30
His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr
35 40 45
Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp Pro
85 90 95
Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1277
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1277
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Asn Asp Val Gly Ser Tyr
20 25 30
Thr Leu Val Ser Trp Tyr Gln Gln Tyr Pro Gly Lys Ala Pro Lys Leu
35 40 45
Leu Ile Phe Glu Val Thr Lys Arg Ser Ser Gly Ile Ser Asn Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Gly Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Ala
85 90 95
Ser Thr Phe Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1278
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1278
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Thr
20 25 30
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
35 40 45
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65 70 75 80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro
85 90 95
Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1279
<211> 106
<212> PRT
<213> Homo sapiens
<400> 1279
Ile Arg Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly Asp
1 5 10 15
Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu
20 25 30
Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr
35 40 45
Val Glu Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu
65 70 75 80
Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Leu Thr
85 90 95
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1280
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1280
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Arg
85 90 95
Ser Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1281
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1281
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro
85 90 95
Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1282
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1282
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser
20 25 30
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
35 40 45
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65 70 75 80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Val Ser Ser Pro
85 90 95
Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1283
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1283
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Arg
85 90 95
Gly Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1284
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1284
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Gly Ser
20 25 30
Tyr Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Leu
35 40 45
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65 70 75 80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Leu
85 90 95
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1285
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1285
Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Ser Tyr Pro Gln
85 90 95
Gly Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1286
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1286
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Gly Pro Arg Leu Leu Ile
35 40 45
Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Arg
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1287
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1287
Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln Ser Ile Thr
1 5 10 15
Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr Asn Leu Val
20 25 30
Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu Met Ile Tyr
35 40 45
Glu Asp Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe Ser Gly Ser
50 55 60
Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Ser Ser Thr Arg
85 90 95
Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1288
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1288
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr
20 25 30
Leu Thr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro
85 90 95
Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1289
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1289
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro
85 90 95
Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1290
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1290
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Val Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro
85 90 95
Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys
100 105
<210> 1291
<211> 106
<212> PRT
<213> Homo sapiens
<400> 1291
Asp Ile Val Met Thr Gln Thr Pro Ala Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Arg Asn Trp Gly Thr
85 90 95
Phe Gly Pro Gly Thr Lys Val Asp Ile Lys
100 105
<210> 1292
<211> 109
<212> PRT
<213> Homo sapiens
<400> 1292
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Arg Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro
85 90 95
Glu Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1293
<211> 109
<212> PRT
<213> Homo sapiens
<400> 1293
Asp Ile Val Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Ser Tyr Pro Pro
85 90 95
Lys Phe Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1294
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1294
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Leu Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr
20 25 30
Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Asp Lys Ala Pro Lys Leu
35 40 45
Met Ile Tyr Asp Val Asn Asn Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Ser Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ala Gly Ser
85 90 95
Ser Thr Gln Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1295
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1295
Gln Ser Val Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr
20 25 30
Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Val Pro Lys Leu
35 40 45
Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser
85 90 95
Ser Ala Gln Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1296
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1296
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr
20 25 30
Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Asp Lys Ala Pro Lys Leu
35 40 45
Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Gly
85 90 95
Ser Thr Gln Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1297
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1297
Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Phe Ala Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Thr Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Ile
85 90 95
Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys
100 105
<210> 1298
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1298
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly
1 5 10 15
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser
20 25 30
Asp Gly Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser
35 40 45
Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Phe Tyr Cys Met Gln Gly
85 90 95
Thr His Trp Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys
100 105 110
<210> 1299
<211> 111
<212> PRT
<213> Homo sapiens
<400> 1299
Gln Ala Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln
1 5 10 15
Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Glu Ala Gly
20 25 30
Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu
35 40 45
Leu Ile Tyr Val Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser
85 90 95
Leu Ser Gly Val Val Phe Gly Gly Gly Thr Lys Leu Ile Val Leu
100 105 110
<210> 1300
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1300
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln
1 5 10 15
Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val
20 25 30
His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr
35 40 45
Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp Pro
85 90 95
Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1301
<211> 109
<212> PRT
<213> Homo sapiens
<400> 1301
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys
1 5 10 15
Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val
20 25 30
His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr
35 40 45
Asp Asp Thr Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Ser Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp His
85 90 95
Pro Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1302
<211> 114
<212> PRT
<213> Homo sapiens
<400> 1302
Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys
1 5 10 15
Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Ile Ala Asn Asn
20 25 30
Tyr Val Lys Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr Val
35 40 45
Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly
65 70 75 80
Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser
85 90 95
Ser Asn His Glu Glu Ile Trp Val Phe Gly Gly Gly Thr Lys Leu Ile
100 105 110
Val Leu
<210> 1303
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1303
Ser Tyr Glu Leu Thr Gln Ser Pro Ser Val Ser Val Ala Pro Gly Gln
1 5 10 15
Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val
20 25 30
His Trp Tyr Gln Arg Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr
35 40 45
Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Asn Asn Ser Asp His
85 90 95
Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1304
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1304
Glu Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser
20 25 30
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
35 40 45
Ile Tyr Gly Val Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gly Ser Glu Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65 70 75 80
Pro Glu Glu Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro
85 90 95
Arg Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1305
<211> 111
<212> PRT
<213> Homo sapiens
<400> 1305
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Ser Thr Pro Gly Gln
1 5 10 15
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn
20 25 30
Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Thr Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg
65 70 75 80
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu
85 90 95
Ser Gly Arg Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1306
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1306
Gln Ala Val Val Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn
20 25 30
Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu
85 90 95
Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1307
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1307
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
1 5 10 15
Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Lys Gln Tyr Ala
20 25 30
Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr
35 40 45
Lys Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Ser Ser Gly Thr Thr Ala Thr Leu Thr Ile Ser Gly Val Gln Ala Glu
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Ala Asp Ser Ser Gly Thr Tyr
85 90 95
Leu Val Val Phe Gly Gly Gly Thr Lys Leu Ala Val
100 105
<210> 1308
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1308
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Trp
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1309
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1309
Gln Ser Ala Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn
20 25 30
Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Val Leu
35 40 45
Val Tyr Ser Asn Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu
85 90 95
Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1310
<211> 111
<212> PRT
<213> Homo sapiens
<400> 1310
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly
1 5 10 15
Thr Val Thr Leu Thr Cys Val Ser Ser Thr Gly Ala Val Thr Ser Gly
20 25 30
Tyr Tyr Pro Asn Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Arg Ala
35 40 45
Leu Ile Tyr Ser Thr Ser Lys Lys His Ser Trp Thr Pro Ala Arg Phe
50 55 60
Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val
65 70 75 80
Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Leu Leu Tyr Tyr Gly Gly
85 90 95
Ala Gln Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1311
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1311
Gln Ser Val Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr
20 25 30
Asn Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Met Ile Tyr Glu Gly Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Tyr Ser Tyr Ala Gly Ser
85 90 95
Ser Thr Phe Val Phe Val Phe Gly Thr Gly Thr Lys Val Ile Val Leu
100 105 110
<210> 1312
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1312
Gln Ser Ala Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn
20 25 30
Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Arg Asn Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Lys Ser Gly Thr Ser Val Ser Leu Ala Ile Ser Gly Leu Arg
65 70 75 80
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu
85 90 95
Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1313
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1313
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Arg
85 90 95
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1314
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1314
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr
20 25 30
Asp Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Met Ile Tyr Glu Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Pro Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Thr Ser Tyr Ala Gly Ser
85 90 95
Asn Asn Phe Val Phe Gly Gly Gly Thr Lys Leu Ile Val Leu
100 105 110
<210> 1315
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1315
Gln Thr Val Val Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr
20 25 30
Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Asp Lys Ala Pro Lys Leu
35 40 45
Ile Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Ala Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser
85 90 95
Ser Thr Gln Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1316
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1316
Gln Ser Ala Leu Thr Gln Pro Thr Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr
20 25 30
Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Ile Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Val Ser
85 90 95
Ser Thr Gln Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1317
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1317
Gln Pro Val Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Leu Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Ile Gly Gly Phe
20 25 30
Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Met Ile Phe Asp Val Ser Lys Arg Pro Ser Gly Val Pro Asn Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Gly Asp Tyr Tyr Cys Ser Ser Tyr Thr Ile Ser
85 90 95
Ser Ala Gln Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1318
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1318
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr
20 25 30
Asn His Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser
85 90 95
Ser Ala Gln Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1319
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1319
Gln Ser Val Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr
20 25 30
Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Val Pro Lys Leu
35 40 45
Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser
85 90 95
Ser Ala Gln Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1320
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1320
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ala Ser Ser Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Val Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys
100 105
<210> 1321
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1321
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Ser Ser Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Glu Ala Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Arg
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys
100 105
<210> 1322
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1322
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp
20 25 30
Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser Tyr Pro Ile
85 90 95
Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1323
<211> 109
<212> PRT
<213> Homo sapiens
<400> 1323
Gln Leu Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys
1 5 10 15
Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val
20 25 30
Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr
35 40 45
Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp His
85 90 95
Pro Tyr Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu
100 105
<210> 1324
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1324
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser
20 25 30
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
35 40 45
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65 70 75 80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Tyr Gly Ser Ser Leu
85 90 95
Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1325
<211> 112
<212> PRT
<213> Mus musculus
<400> 1325
Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly
1 5 10 15
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser
20 25 30
Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly
85 90 95
Ser His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105 110
<210> 1326
<211> 109
<212> PRT
<213> Homo sapiens
<400> 1326
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro
85 90 95
Ala Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1327
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1327
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr
20 25 30
Asn Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Met Ile Tyr Glu Gly Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Ser
85 90 95
Ser Thr Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1328
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1328
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly
1 5 10 15
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser
20 25 30
Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala
85 90 95
Leu Gln Thr Pro Gly Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys
100 105 110
<210> 1329
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1329
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly
1 5 10 15
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser
20 25 30
Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala
85 90 95
Leu Gln Thr Pro Gly Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys
100 105 110
<210> 1330
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1330
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Gly Asp Val Gly Ser Tyr
20 25 30
Asn Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Val Ile Tyr Glu Ala Thr Lys Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Phe Ala Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Val
85 90 95
Arg Thr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1331
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1331
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Gly Asp Ile Gly Ser Tyr
20 25 30
Asn Leu Val Ser Trp Tyr Gln Gln Tyr Pro Gly Lys Ala Pro Lys Leu
35 40 45
Ile Ile Tyr Glu Ala Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Phe Ala Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Val
85 90 95
Arg Thr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1332
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1332
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser
20 25 30
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
35 40 45
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65 70 75 80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro
85 90 95
Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1333
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1333
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Thr Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Leu Phe
85 90 95
Thr Phe Gly Pro Gly Thr Lys Val Asp Val Lys
100 105
<210> 1334
<211> 111
<212> PRT
<213> Homo sapiens
<400> 1334
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Gly Asp Val Gly Ala Tyr
20 25 30
Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Val Lys Ala Pro Lys Leu
35 40 45
Met Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser
85 90 95
Ser Thr Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1335
<211> 86
<212> PRT
<213> Homo sapiens
<400> 1335
Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr
1 5 10 15
Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser
20 25 30
Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Gly Gly Ser Ala Ser Gly
35 40 45
Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala
50 55 60
Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Phe Thr Phe Gly Pro Gly
65 70 75 80
Thr Lys Val Asp Ile Lys
85
<210> 1336
<211> 113
<212> PRT
<213> Homo sapiens
<400> 1336
Asp Ile Val Met Thr Gln Ser Pro Asp Phe Leu Ala Val Ser Leu Gly
1 5 10 15
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu His Thr
20 25 30
Pro Lys Asn Lys Asn Tyr Leu Ala Trp Tyr Lys Gln Lys Pro Gly Gln
35 40 45
Pro Pro Lys Val Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
Pro Glu Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Ile
65 70 75 80
Ile Ser Ser Leu Gln Ala Glu Asp Ala Ala Val Tyr Tyr Cys Gln Gln
85 90 95
Tyr Tyr Thr Ala Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile
100 105 110
Lys
<210> 1337
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1337
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Asp Thr Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro
85 90 95
Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1338
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1338
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr
20 25 30
His Tyr Val Ser Trp Tyr Gln His His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Ile Ile Tyr Asp Val Ile Lys Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Tyr Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser
85 90 95
Thr Thr Trp Val Phe Gly Gly Gly Thr Arg Leu Thr Val Leu
100 105 110
<210> 1339
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1339
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln
1 5 10 15
Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly
20 25 30
Tyr Asn Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu
35 40 45
Leu Ile Tyr Gly Asn Asn Asn Arg Pro Ser Gly Val Pro Asp Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Phe Asp Ser Ser
85 90 95
Leu Ser Gly Ser Asp Val Phe Gly Thr Gly Thr Lys Val Ser Val Leu
100 105 110
<210> 1340
<211> 111
<212> PRT
<213> Homo sapiens
<400> 1340
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn
20 25 30
Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg
65 70 75 80
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Ala Ser Leu
85 90 95
Ser Gly His Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1341
<211> 113
<212> PRT
<213> Homo sapiens
<400> 1341
Asp Ile Val Met Ala Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly
1 5 10 15
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Asp Ser
20 25 30
Asp Asp Gly Asn Thr Tyr Phe Asp Trp Tyr Leu Gln Lys Pro Gly Gln
35 40 45
Ser Pro Gln Leu Leu Ile Tyr Thr Leu Ser Tyr Arg Ala Ser Gly Val
50 55 60
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys
65 70 75 80
Ile Asn Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln
85 90 95
Arg Ile Glu Phe Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile
100 105 110
Lys
<210> 1342
<211> 113
<212> PRT
<213> Homo sapiens
<400> 1342
Asp Ile Val Met Thr Gln Ser Pro Asp Phe Leu Ala Val Ser Leu Gly
1 5 10 15
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu His Thr
20 25 30
Pro Lys Asn Lys Asn Tyr Leu Ala Trp Tyr Lys Gln Lys Pro Gly Gln
35 40 45
Pro Pro Lys Val Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
Pro Glu Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Ile
65 70 75 80
Ile Ser Ser Leu Gln Ala Glu Asp Ala Ala Val Tyr Tyr Cys Gln Gln
85 90 95
Tyr Tyr Thr Ala Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile
100 105 110
Lys
<210> 1343
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1343
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Thr Asn Tyr
20 25 30
Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile
35 40 45
Tyr Ala Val Ser Ser Leu Gln Ser Gly Val Pro Ser Lys Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Trp
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1344
<211> 109
<212> PRT
<213> Homo sapiens
<400> 1344
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
1 5 10 15
Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Lys Gln Tyr Ala
20 25 30
Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr
35 40 45
Lys Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Ser Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Val Gln Ala Glu
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Ala Asp Ser Ser Gly Thr Tyr
85 90 95
Phe Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1345
<211> 113
<212> PRT
<213> Homo sapiens
<400> 1345
Asp Ile Val Met Thr Gln Ser Pro Asp Phe Leu Ala Val Ser Leu Gly
1 5 10 15
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu His Thr
20 25 30
Pro Lys Asn Lys Asn Tyr Leu Ala Trp Tyr Lys Gln Lys Pro Gly Gln
35 40 45
Pro Pro Lys Val Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
Pro Glu Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Ile
65 70 75 80
Ile Ser Ser Leu Gln Ala Glu Asp Ala Ala Val Tyr Tyr Cys Gln Gln
85 90 95
Tyr Tyr Thr Ala Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile
100 105 110
Lys
<210> 1346
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1346
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln
1 5 10 15
Arg Val Thr Ile Ser Cys Ser Gly Ser Asn Ser Lys Ile Gly Ser Tyr
20 25 30
Ser Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Phe
50 55 60
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Val Trp Asp Asp Ser Leu
85 90 95
Asn Gly Pro Leu Phe Gly Gly Gly Thr Lys Leu Thr Phe Val
100 105 110
<210> 1347
<211> 106
<212> PRT
<213> Homo sapiens
<400> 1347
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
1 5 10 15
Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Trp Pro Asn Gln Tyr Ala
20 25 30
Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr
35 40 45
Lys Asp Thr Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Ser Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Val Gln Ala Glu
65 70 75 80
Asp Glu Ala Asp Tyr Phe Cys Gln Ser Ser Asp Ser Ser Gly Val Val
85 90 95
Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1348
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1348
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Ser Trp
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1349
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1349
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Arg Val Thr Ile Ser Cys Ser Gly Ser Asn Ser Lys Ile Gly Ser Tyr
20 25 30
Ser Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Val Trp Asp Asp Ser Leu
85 90 95
Asn Gly Pro Leu Phe Gly Gly Gly Thr Lys Leu Thr Phe Leu
100 105 110
<210> 1350
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1350
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro
85 90 95
Thr Phe Gly Gly Gly Thr Lys Val Gln Ile Lys
100 105
<210> 1351
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1351
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Asn Thr Pro Arg
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1352
<211> 106
<212> PRT
<213> Homo sapiens
<400> 1352
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Asn Ser Phe Pro Thr
85 90 95
Phe Gly Gln Gly Thr Arg Leu Glu Ile Arg
100 105
<210> 1353
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1353
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser
20 25 30
Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
35 40 45
Ile Tyr Gly Ala Ser Asn Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65 70 75 80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Asn Ser Pro
85 90 95
Gln Phe Gly Pro Gly Thr Lys Val Asp Ile Lys
100 105
<210> 1354
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1354
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asn Trp
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Ser Thr
85 90 95
Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1355
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1355
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Phe
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Phe Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Asn Thr Pro Tyr
85 90 95
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1356
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1356
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Arg Val Ile Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn
20 25 30
Thr Val Lys Trp Tyr His Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
35 40 45
Ile Cys Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Lys Ser Asp Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu
85 90 95
Asn Ala Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1357
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1357
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ala Gly Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Gly Thr Thr Ser Leu Gln Ser Gly Val Pro Val Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Gly
85 90 95
Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys
100 105
<210> 1358
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1358
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Asn His Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Thr Ser Leu Gln Pro
65 70 75 80
Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asp Asn Leu Pro Met
85 90 95
Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1359
<211> 109
<212> PRT
<213> Homo sapiens
<400> 1359
Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys
1 5 10 15
Thr Ala Arg Ile Thr Cys Glu Gly Asn Asn Ile Gly Ser Lys Ser Val
20 25 30
His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr
35 40 45
Asp Asp Ser Gly Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly
65 70 75 80
Asp Glu Ala Asp Tyr Phe Cys Gln Val Trp Asp Ser Ser Ser Asp His
85 90 95
His Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1360
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1360
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Arg Val Thr Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Ser Tyr
20 25 30
Thr Val Asn Trp Tyr Gln Gln Phe Pro Gly Thr Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Asp Asn Asn Gln Arg Thr Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp Glu Ala Asn Tyr Tyr Cys Leu Val Trp Asp Asp Ser Leu
85 90 95
Asn Gly Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1361
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1361
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln
1 5 10 15
Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ser Gly
20 25 30
Ser Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu
35 40 45
Leu Ile Tyr Gly Asn Thr Asn Arg Pro Ser Gly Val Pro Asp Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Arg
85 90 95
Leu Ser Gly Phe Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1362
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1362
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asn Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Ser Cys Gln Gln Ser Tyr Thr Thr Leu Leu
85 90 95
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1363
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1363
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser
20 25 30
Tyr Leu Gly Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
35 40 45
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65 70 75 80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro
85 90 95
Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1364
<211> 111
<212> PRT
<213> Homo sapiens
<400> 1364
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln
1 5 10 15
Arg Val Thr Leu Ser Cys Thr Gly Ser Asn Ser Asn Ile Gly Ala Gly
20 25 30
Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu
35 40 45
Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser
85 90 95
Leu Ser Asp Ser Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 1365
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1365
Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Thr Ala Pro Asn Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Leu Leu Asn Ser His Pro Leu
85 90 95
Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys
100 105
<210> 1366
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1366
Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln
1 5 10 15
Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala
20 25 30
Ser Trp Tyr Gln Gln Lys Pro Gly Gln Val Pro Ile Leu Val Ile Tyr
35 40 45
Asp Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser
50 55 60
Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn Ala
85 90 95
Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1367
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1367
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ala Asn Leu Pro Phe
85 90 95
Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys
100 105
<210> 1368
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1368
Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln
1 5 10 15
Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala
20 25 30
Ser Trp Tyr Gln Gln Lys Pro Gly Gln Val Pro Ile Leu Val Ile Tyr
35 40 45
Asp Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser
50 55 60
Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn Ala
85 90 95
Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1369
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1369
Gln Ser Val Leu Thr Gln Ala Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Arg Val Thr Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Ser Tyr
20 25 30
Thr Ile Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Gly Asn Asp Gln Arg Thr Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Lys Phe Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp Glu Asn Asn Tyr Tyr Cys Ala Val Trp Asp Asp Ser Leu
85 90 95
Asn Gly Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1370
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1370
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Ala Ser Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Glu Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Trp
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1371
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1371
Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
1 5 10 15
Glu Arg Ala Ile Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Ser Asn
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Ser Gly Ala Ser Thr Arg Ala Thr Ala Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Thr Ser Leu Gln Ser
65 70 75 80
Glu Asp Cys Ala Val Tyr Tyr Cys His Gln Tyr Asn Asn Trp Pro Gln
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1372
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1372
Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys
1 5 10 15
Thr Val Thr Ile Ser Cys Thr Gly Ser Ser Gly Ser Ile Ala Ser Asn
20 25 30
Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ala Pro Thr Thr Val
35 40 45
Ile Ser Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly
65 70 75 80
Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly
85 90 95
Ile Asn Arg Ala Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1373
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1373
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly
1 5 10 15
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser
20 25 30
Leu Gly Tyr Asn Ser Leu Ser Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro His Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Ala Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Leu Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala
85 90 95
Leu Gln Thr Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys
100 105 110
<210> 1374
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1374
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Cys Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Gly Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ser Leu Ser
85 90 95
Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys
100 105
<210> 1375
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1375
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Glu Ile Pro Pro
85 90 95
Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1376
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1376
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Asn Asn Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Leu Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Ile Phe Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Pro
85 90 95
Val Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1377
<211> 111
<212> PRT
<213> Homo sapiens
<400> 1377
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln
1 5 10 15
Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly
20 25 30
Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Glu Thr Ala Pro Lys Leu
35 40 45
Leu Ile Tyr Ala Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser
85 90 95
Leu Ser Gly Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1378
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1378
Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys
1 5 10 15
Thr Val Thr Ile Ser Cys Thr Gly Ser Ser Gly Ser Ile Ala Ser Asn
20 25 30
Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ala Pro Thr Thr Val
35 40 45
Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly
65 70 75 80
Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser
85 90 95
Gly Asn Pro Ile Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1379
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1379
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser
20 25 30
Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
35 40 45
Pro Pro Lys Leu Leu Met Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Ala Glu Phe Thr Leu Thr
65 70 75 80
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Ile Tyr Tyr Cys Gln Gln
85 90 95
Tyr Tyr Ser Thr Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105 110
<210> 1380
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1380
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Asn Asn Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Leu Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Pro
85 90 95
Val Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1381
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1381
Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys
1 5 10 15
Thr Val Thr Phe Ser Cys Thr Gly Ser Ser Gly Ser Ile Ala Ser Asn
20 25 30
Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ala Pro Thr Thr Val
35 40 45
Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly
65 70 75 80
Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly
85 90 95
Ile Asn Arg Trp Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1382
<211> 117
<212> PRT
<213> Homo sapiens
<400> 1382
Gln Pro Val Leu Thr Gln Pro Pro Ser Ala Ser Ala Ser Leu Gly Ala
1 5 10 15
Ser Val Thr Leu Thr Cys Thr Leu Ser Ser Gly Tyr Ser Asn Tyr Lys
20 25 30
Val Asp Trp Tyr Gln Gln Arg Pro Gly Lys Gly Pro Arg Phe Val Met
35 40 45
Arg Val Gly Thr Gly Gly Ile Val Gly Ser Lys Gly Asp Gly Ile Pro
50 55 60
Asp Arg Phe Ser Val Leu Gly Ser Gly Leu Asn Arg Tyr Leu Thr Ile
65 70 75 80
Lys Asn Ile Gln Glu Glu Asp Glu Ser Asp Tyr His Cys Gly Ala Asp
85 90 95
His Gly Ser Gly Ser Asn Phe Glu Tyr Val Val Phe Gly Gly Gly Thr
100 105 110
Lys Leu Thr Val Leu
115
<210> 1383
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1383
Gln Ser Val Val Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Tyr Asn
20 25 30
Ile Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ser Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu
85 90 95
Asn Gly Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 1384
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1384
Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Ser Tyr Pro Val
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1385
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1385
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Asp Tyr
20 25 30
Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Glu Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser
85 90 95
Ser Thr Leu Leu Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 1386
<211> 109
<212> PRT
<213> Homo sapiens
<400> 1386
Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys
1 5 10 15
Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Asn Lys Gly Val
20 25 30
His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Asp
35 40 45
Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Asn Ser Gly Asn Thr Ala Thr Leu Ile Ile Ser Ser Val Glu Val Gly
65 70 75 80
Asp Glu Ala Asp Phe Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp His
85 90 95
Pro Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1387
<211> 109
<212> PRT
<213> Homo sapiens
<400> 1387
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Phe
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys His Tyr Arg Ser Asn Trp Pro Pro
85 90 95
Val Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Glu
100 105
<210> 1388
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1388
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Thr Asn Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Tyr Ser
85 90 95
Val His Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1389
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1389
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Asp Tyr
20 25 30
Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Glu Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser
85 90 95
Ser Thr Leu Leu Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 1390
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1390
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Asp Tyr
20 25 30
Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Glu Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser
85 90 95
Ser Thr Leu Leu Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 1391
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1391
Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Thr Ala Pro Asn Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Leu Leu Asn Ser His Pro Leu
85 90 95
Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys
100 105
<210> 1392
<211> 109
<212> PRT
<213> Homo sapiens
<400> 1392
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Phe
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Arg Pro Thr Gly Ile Pro Ala Arg Phe Thr Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Arg Thr Asn Trp Pro Pro
85 90 95
Leu Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys
100 105
<210> 1393
<211> 106
<212> PRT
<213> Homo sapiens
<400> 1393
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
1 5 10 15
Thr Ala Ser Ile Thr Cys Ser Gly Asp Lys Leu Gly Asp Lys Tyr Ala
20 25 30
Cys Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro Val Leu Val Ile Tyr
35 40 45
Gln Asp Ser Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Ser Thr Gly Val
85 90 95
Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105
<210> 1394
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1394
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Thr Trp
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile
35 40 45
Tyr Glu Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Thr Tyr Ser Gly
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1395
<211> 106
<212> PRT
<213> Homo sapiens
<400> 1395
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
1 5 10 15
Thr Ala Ser Ile Thr Cys Ser Gly Asp Lys Leu Gly Asp Lys Tyr Ala
20 25 30
Cys Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro Val Leu Val Ile Tyr
35 40 45
Gln Asp Ser Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Ser Thr Gly Val
85 90 95
Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105
<210> 1396
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1396
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Arg Gln Ser Ile Ser Asn Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Tyr Ser Thr Phe Trp
85 90 95
Thr Phe Gly Gln Gly Thr Asn Val Glu Ile Lys
100 105
<210> 1397
<211> 106
<212> PRT
<213> Homo sapiens
<400> 1397
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
1 5 10 15
Thr Ala Ser Ile Thr Cys Ser Gly Asp Lys Leu Gly Asp Lys Tyr Ala
20 25 30
Cys Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Val Val Ile Tyr
35 40 45
Gln Asp Ser Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Ser Thr Ala Val
85 90 95
Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1398
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1398
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr
20 25 30
Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Cys Cys Ser Ser Tyr Thr Ser Ser
85 90 95
Arg Ala Val Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1399
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1399
Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys
1 5 10 15
Thr Ala Asn Ile Thr Cys Gly Gly Asn Asn Ile Gly Arg Lys Ser Val
20 25 30
His Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Val Leu Val Val Tyr
35 40 45
Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp His
85 90 95
Pro Glu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1400
<211> 106
<212> PRT
<213> Homo sapiens
<400> 1400
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Gly Ala Ser Ser Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Arg Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Ser Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Thr
85 90 95
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1401
<211> 111
<212> PRT
<213> Homo sapiens
<400> 1401
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Ile Gly Gly Tyr
20 25 30
Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Leu Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Thr Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser
85 90 95
Ser Thr His Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1402
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1402
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Thr Trp
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile
35 40 45
Tyr Glu Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Thr Tyr Ser Gly
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1403
<211> 113
<212> PRT
<213> Homo sapiens
<400> 1403
Asp Ile Val Met Thr Gln Ser Pro Asp Phe Leu Ala Val Ser Leu Gly
1 5 10 15
Glu Arg Ala Thr Ile Ser Cys Lys Ser Ser Gln Ser Val Leu Tyr Thr
20 25 30
Pro Lys Asn Lys Asn Tyr Leu Ala Trp Tyr Lys Gln Lys Pro Gly Gln
35 40 45
Pro Pro Lys Val Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Ile
65 70 75 80
Ile Ser Ser Leu Gln Ala Glu Asp Ala Ala Val Tyr Tyr Cys Gln Gln
85 90 95
Tyr Tyr Thr Ala Pro Leu Thr Phe Gly Gly Gly Thr Arg Val Glu Ile
100 105 110
Lys
<210> 1404
<211> 109
<212> PRT
<213> Homo sapiens
<400> 1404
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser
20 25 30
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
35 40 45
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65 70 75 80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Tyr Gly Ser Ser Arg
85 90 95
Gly Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1405
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1405
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn
20 25 30
Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
35 40 45
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65 70 75 80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Arg Ser Pro
85 90 95
Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys
100 105
<210> 1406
<211> 106
<212> PRT
<213> Homo sapiens
<400> 1406
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
1 5 10 15
Thr Ala Ser Ile Thr Cys Phe Gly Asp Lys Leu Gly Asp Lys Tyr Ala
20 25 30
Cys Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Ile Ile Tyr
35 40 45
Gln Gly Ala Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Ser Thr Val Val
85 90 95
Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1407
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1407
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Thr Asn Tyr
20 25 30
Leu Asn Trp Tyr Gln Leu Lys Ser Gly Arg Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Tyr
85 90 95
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1408
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1408
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln
1 5 10 15
Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly
20 25 30
Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu
35 40 45
Leu Ile Phe Ile Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser
85 90 95
Leu Gly Ala Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1409
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1409
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Pro
85 90 95
Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys
100 105
<210> 1410
<211> 106
<212> PRT
<213> Homo sapiens
<400> 1410
Glu Ile Val Leu Thr Gln Ser Pro Ala Ile Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Asp Thr Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro
65 70 75 80
Glu Asp Phe Ala Phe Tyr Tyr Cys Gln Gln Arg Gly Asn Trp Trp Thr
85 90 95
Phe Ala Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1411
<211> 109
<212> PRT
<213> Homo sapiens
<400> 1411
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Phe
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Arg Pro Thr Gly Ile Pro Ala Arg Phe Thr Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Arg Thr Asn Trp Pro Pro
85 90 95
Leu Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys
100 105
<210> 1412
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1412
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Asn Asn
20 25 30
Leu Ala Trp Tyr Gln His Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
65 70 75 80
Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Cys Tyr Asn Trp Pro Pro
85 90 95
Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1413
<211> 109
<212> PRT
<213> Homo sapiens
<400> 1413
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Asp Pro
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys His Lys Arg Ser Asn Trp Pro Pro
85 90 95
Ser Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1414
<211> 113
<212> PRT
<213> Homo sapiens
<400> 1414
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser
20 25 30
Ser Asn Asn Lys Asn Ser Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
35 40 45
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln
85 90 95
Tyr Tyr Ser Ile Ser Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile
100 105 110
Lys
<210> 1415
<211> 111
<212> PRT
<213> Homo sapiens
<400> 1415
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr
20 25 30
Asn Leu Val Ser Trp Tyr Gln Gln His Ala Gly Lys Ala Pro Lys Leu
35 40 45
Met Ile Tyr Glu Val Ile Lys Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Val Ser
85 90 95
Thr Thr Tyr Val Ile Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1416
<211> 113
<212> PRT
<213> Homo sapiens
<400> 1416
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu His Ser
20 25 30
Ser Asn Asn Lys Asp Ser Leu Val Trp Tyr Gln Gln Lys Pro Gly Gln
35 40 45
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ser Arg Glu Ser Gly Val
50 55 60
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln
85 90 95
Tyr Tyr Ser Thr Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile
100 105 110
Lys
<210> 1417
<211> 117
<212> PRT
<213> Homo sapiens
<400> 1417
Gln Pro Val Leu Thr Gln Pro Pro Ser Ala Ser Ala Ser Leu Gly Ala
1 5 10 15
Ser Val Thr Leu Thr Cys Thr Leu Ser Ser Gly Tyr Ser Asn Tyr Lys
20 25 30
Val Asp Trp Tyr Gln Gln Arg Pro Gly Lys Gly Pro Arg Phe Val Met
35 40 45
Arg Val Gly Thr Gly Gly Ile Val Gly Ser Lys Gly Asp Gly Ile Pro
50 55 60
Asp Arg Phe Ser Val Leu Gly Ser Gly Leu Asn Arg Tyr Leu Thr Ile
65 70 75 80
Lys Asn Ile Gln Glu Glu Asp Glu Ser Asp Tyr His Cys Gly Ala Asp
85 90 95
His Gly Ser Gly Ser Asn Phe Val Phe Val Val Phe Gly Gly Gly Thr
100 105 110
Lys Leu Thr Val Leu
115
<210> 1418
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1418
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly
1 5 10 15
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser
20 25 30
Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Gln Phe Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ile Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala
85 90 95
Leu Gln Thr Pro Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys
100 105 110
<210> 1419
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1419
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Tyr Trp Pro Pro
85 90 95
Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1420
<211> 109
<212> PRT
<213> Homo sapiens
<400> 1420
Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys
1 5 10 15
Thr Ala Arg Ile Thr Cys Glu Gly Asn Asn Ile Gly Ser Lys Ser Val
20 25 30
His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr
35 40 45
Asp Asp Ser Gly Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly
65 70 75 80
Asp Glu Ala Asp Tyr Phe Cys Gln Val Trp Asp Ser Ser Ser Asp His
85 90 95
His Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1421
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1421
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser His Ser Ile Ser Ser Trp
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Thr Tyr Ser Gln
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1422
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1422
Phe Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
1 5 10 15
Thr Ala Gly Ile Thr Cys Ser Gly Asp Lys Leu Gly His Lys Tyr Ala
20 25 30
Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Ile Leu Leu Ile Tyr
35 40 45
Gln Asp Asp Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Asn Ser Gly Thr Ile Ala Thr Leu Thr Ile Ser Gly Thr Gln Pro Val
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Asn Asp Ala Gly Val
85 90 95
Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1423
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1423
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr
20 25 30
Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Lys Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser His Pro Pro
85 90 95
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1424
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1424
Gln Ser Ala Leu Thr Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Thr Tyr
20 25 30
Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Met Ile Tyr Glu Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Glu Tyr Tyr Cys Ser Ala Tyr Ala Gly Ser
85 90 95
Asn Asn Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1425
<211> 117
<212> PRT
<213> Homo sapiens
<400> 1425
Gln Pro Val Leu Thr Gln Pro Pro Ser Ala Ser Ala Ser Leu Gly Ala
1 5 10 15
Ser Val Thr Leu Thr Cys Thr Leu Ser Ser Gly Tyr Ser Asn Tyr Lys
20 25 30
Val Asp Trp Tyr Gln Gln Arg Pro Gly Lys Gly Pro Arg Phe Val Met
35 40 45
Arg Val Gly Thr Gly Gly Ile Val Gly Ser Lys Gly Asp Gly Ile Pro
50 55 60
Asp Arg Phe Ser Val Leu Gly Ser Gly Leu Asn Arg Tyr Leu Thr Ile
65 70 75 80
Lys Asn Ile Gln Glu Glu Asp Glu Ser Asp Tyr His Cys Gly Ala Asp
85 90 95
His Gly Ser Gly Ser Asn Phe Glu Tyr Val Val Phe Gly Gly Gly Thr
100 105 110
Lys Leu Thr Val Leu
115
<210> 1426
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1426
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser His Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr
20 25 30
Asn Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Met Ile Tyr Glu Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Ser Gly Ser Thr Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Ile
85 90 95
Val Leu Phe Gly Gly Gly Thr Lys Val Thr Val Leu
100 105
<210> 1427
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1427
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
1 5 10 15
Thr Thr Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Lys Gln Tyr Gly
20 25 30
Tyr Trp Tyr Gln Gln Lys Ala Gly Gln Ala Pro Ile Leu Val Ile Tyr
35 40 45
Lys Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Ser Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Val Gln Ala Glu
65 70 75 80
Asp Glu Ala His Tyr Tyr Cys Gln Ser Gly Asp Ser Ser Gly Thr Tyr
85 90 95
Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1428
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1428
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
1 5 10 15
Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Ser Lys Gln Tyr Ala
20 25 30
Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr
35 40 45
Lys Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Ser Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Val Gln Ala Glu
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Val Asp Arg Ser Gly Thr Tyr
85 90 95
Phe Asn Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1429
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1429
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Thr Asn Tyr
20 25 30
Leu Asn Trp Tyr Gln Leu Lys Ser Gly Arg Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Tyr
85 90 95
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1430
<211> 109
<212> PRT
<213> Homo sapiens
<400> 1430
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly
1 5 10 15
Thr Val Thr Leu Thr Cys Ala Ser Ser Ala Gly Ala Val Thr Ser Gly
20 25 30
Tyr Tyr Pro Asn Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Arg Ala
35 40 45
Leu Ile Tyr Ser Thr Ala Asn Lys His Ser Trp Thr Leu Ala Arg Phe
50 55 60
Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val
65 70 75 80
Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Leu Leu Tyr Tyr Gly Gly
85 90 95
Ala Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1431
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1431
Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys
1 5 10 15
Thr Val Thr Ile Ser Cys Thr Gly Ser Ser Gly Ser Ile Ala Ser Asn
20 25 30
Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ala Pro Thr Thr Val
35 40 45
Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly
65 70 75 80
Leu Met Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly
85 90 95
Ser Asn His Ala Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1432
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1432
Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys
1 5 10 15
Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Asn Val
20 25 30
His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Val Val Val Tyr
35 40 45
Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp Pro
85 90 95
Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1433
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1433
Asn Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly
1 5 10 15
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Asn Ser
20 25 30
Asn Gly Leu Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Gln Leu Leu Ile Tyr Phe Val Ser Asn Arg Ala Ser Gly Val Ser
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Ala Asp Phe Thr Leu Thr Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala
85 90 95
Leu Gln Thr Pro Gln Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105 110
<210> 1434
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1434
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Gly Ala Ser Gln Ser Ile Ser Ser Ser
20 25 30
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
35 40 45
Ile Tyr Gly Ala Ser Ser Arg Ala Ala Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65 70 75 80
Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Tyr Gly Gly Ser Leu
85 90 95
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1435
<211> 106
<212> PRT
<213> Homo sapiens
<400> 1435
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
1 5 10 15
Thr Ala Ser Ile Thr Cys Ser Gly Asp Lys Met Gly Asp Lys Tyr Ala
20 25 30
Cys Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Val Val Ile Tyr
35 40 45
Glu Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Ser Leu Val Val
85 90 95
Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1436
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1436
Gln Ser Ala Leu Thr Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr
20 25 30
Asn Arg Val Ser Trp Tyr Gln Gln Pro Pro Gly Thr Ala Pro Lys Leu
35 40 45
Met Ile Tyr Glu Val Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser
85 90 95
Ser Leu Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1437
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1437
Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Ser Tyr Pro Val
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1438
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1438
Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr
20 25 30
Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Met Ile Tyr Asp Val Thr Lys Arg Pro Ser Gly Val Pro Glu Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Ser Cys Cys Ser Tyr Ala Gly Ser
85 90 95
Tyr Thr Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 1439
<211> 111
<212> PRT
<213> Homo sapiens
<400> 1439
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Gly Ser Asp Val Gly Gly Ser
20 25 30
Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser
85 90 95
Ser Thr Leu Val Leu Phe Gly Gly Gly Thr Lys Leu Ser Val Leu
100 105 110
<210> 1440
<211> 109
<212> PRT
<213> Homo sapiens
<400> 1440
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Phe
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro
85 90 95
Ser Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1441
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1441
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Ile Gly Gly Tyr
20 25 30
Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ile
85 90 95
Ser Thr Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 1442
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1442
Ser Tyr Glu Leu Thr Gln Pro Ser Ser Val Ser Val Ser Pro Gly Gln
1 5 10 15
Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Lys Arg Tyr Ala
20 25 30
Tyr Trp Tyr Arg Gln Lys Ser Gly Gln Ala Pro Val Leu Val Ile His
35 40 45
Glu Asp Ser Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Thr Ser Gly Thr Met Ala Thr Leu Thr Ile Thr Gly Ala Gln Leu Glu
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Phe Ser Met Asp Ser Ser Gly Asp Leu
85 90 95
Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1443
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1443
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Thr Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Tyr Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Gly
85 90 95
Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1444
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1444
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Val Gly Tyr
20 25 30
Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Met Ile Tyr Asp Val Arg Asn Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Phe Cys Ile Ser Tyr Thr Ser Ser
85 90 95
Arg Thr Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1445
<211> 109
<212> PRT
<213> Homo sapiens
<400> 1445
Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys
1 5 10 15
Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Asn Val
20 25 30
His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr
35 40 45
Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Tyr Tyr His
85 90 95
Pro Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1446
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1446
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Arg Val Thr Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Ser Tyr
20 25 30
Thr Val Asn Trp Tyr Gln Gln Phe Pro Gly Thr Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Asp Asn Asn Gln Arg Thr Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp Glu Ala Asn Tyr Tyr Cys Leu Val Trp Asp Asp Ser Leu
85 90 95
Asn Gly Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1447
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1447
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln
1 5 10 15
Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn
20 25 30
Tyr Ile Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln
65 70 75 80
Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu
85 90 95
Ser Ala Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1448
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1448
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Asn Ser Trp
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Ile Tyr Ser Trp
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1449
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1449
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Cys Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Gly Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Trp
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1450
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1450
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Arg Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Leu Pro Leu
85 90 95
Thr Phe Gly Gly Gly Thr Lys Val Glu Val Lys
100 105
<210> 1451
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1451
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Glu Ser Asn
20 25 30
Ser Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu
85 90 95
Asn Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1452
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1452
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Arg Val Thr Ile Ser Cys Ser Gly Ser Thr Ser Asn Ile Gly Ser Asn
20 25 30
Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Lys Ser Gly Pro Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Val Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu
85 90 95
Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1453
<211> 106
<212> PRT
<213> Homo sapiens
<400> 1453
Ser Tyr Glu Leu Thr Gln Ser Pro Ser Val Ser Val Ser Pro Gly Gln
1 5 10 15
Thr Ala Ser Ile Thr Cys Ser Gly Asp Lys Leu Gly Asp Lys Tyr Ala
20 25 30
Cys Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro Val Leu Val Ile Tyr
35 40 45
Gln Asp Ser Gln Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Ser Thr Ala Val
85 90 95
Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1454
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1454
Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
1 5 10 15
Glu Arg Ala Ile Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Ser Asn
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Ser Gly Ala Ser Thr Arg Ala Thr Ala Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Thr Ser Leu Gln Ser
65 70 75 80
Glu Asp Cys Ala Val Tyr Tyr Cys His Gln Tyr Asn Asn Trp Pro Gln
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1455
<211> 106
<212> PRT
<213> Homo sapiens
<400> 1455
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Thr Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr His Cys Gln Gln Ser Tyr Ser Thr Leu Thr
85 90 95
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1456
<211> 109
<212> PRT
<213> Homo sapiens
<400> 1456
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Arg Ser Asn Trp Pro Pro
85 90 95
Arg Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1457
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1457
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ala Gly Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Gly Thr Thr Ser Leu Gln Ser Gly Val Pro Val Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Gly
85 90 95
Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys
100 105
<210> 1458
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1458
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser
20 25 30
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
35 40 45
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65 70 75 80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Tyr
85 90 95
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1459
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1459
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Arg Gln Ser Ile Ser Asn Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Tyr Ser Thr Phe Trp
85 90 95
Thr Phe Gly Gln Gly Thr Asn Val Glu Ile Lys
100 105
<210> 1460
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1460
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn
20 25 30
Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
35 40 45
Ile Ser Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg
65 70 75 80
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu
85 90 95
Ser Ser Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1461
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1461
Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys
1 5 10 15
Thr Val Thr Ile Ser Cys Thr Gly Ser Ser Gly Ser Ile Ala Ser Asn
20 25 30
Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ala Pro Thr Thr Val
35 40 45
Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly
65 70 75 80
Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser
85 90 95
Gly Asn Pro Ile Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1462
<211> 106
<212> PRT
<213> Homo sapiens
<400> 1462
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
1 5 10 15
Thr Ala Ser Ile Thr Cys Ser Gly Asp Lys Leu Gly Asp Lys Tyr Ser
20 25 30
Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr
35 40 45
Glu Asp Thr Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Ser Ser Ser Thr Ala Val
85 90 95
Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1463
<211> 111
<212> PRT
<213> Homo sapiens
<400> 1463
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr
20 25 30
Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Met Ile Tyr Tyr Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser
85 90 95
Thr Leu Asn Val Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1464
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1464
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Arg Gln Ser Ile Ser Asn Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Gly
85 90 95
Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys
100 105
<210> 1465
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1465
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln
1 5 10 15
Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly
20 25 30
Tyr Asp Val His Trp Tyr Gln His Leu Pro Gly Thr Ala Pro Lys Leu
35 40 45
Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser
85 90 95
Leu Ser Gly Trp Ser Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 1466
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1466
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Asp Tyr
20 25 30
Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Glu Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser
85 90 95
Ser Thr Leu Leu Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 1467
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1467
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ile Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr His Met
85 90 95
Ser Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1468
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1468
Asp Ile Val Val Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly
1 5 10 15
Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Glu Thr Leu Leu His Ser
20 25 30
Asp Gly Lys Thr Tyr Leu Ser Trp Tyr Leu Gln Lys Pro Gly Gln Pro
35 40 45
Pro Gln Leu Leu Ile Tyr Glu Val Ser Asn Arg Phe Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Gly Arg Val Glu Ala Glu Asp Val Gly Leu Tyr Tyr Cys Met Gln Ser
85 90 95
Ile Gln Leu Ala Phe Gly Gln Gly Thr Arg Leu Glu Ile Glu
100 105 110
<210> 1469
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1469
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Tyr Trp Pro Pro
85 90 95
Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1470
<211> 109
<212> PRT
<213> Homo sapiens
<400> 1470
Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln
1 5 10 15
Thr Val Thr Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser His Tyr Ala
20 25 30
Ser Trp Tyr Lys Val Lys Pro Gly Gln Ala Pro Leu Leu Val Ile Tyr
35 40 45
Gly Arg Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser
50 55 60
Arg Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Val Asp
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Gly Asp Ser Ser Thr Asp His
85 90 95
His Val Val Phe Ala Gly Gly Thr Lys Leu Ala Val Val
100 105
<210> 1471
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1471
Asp Met Glu Val Thr Gln Phe Pro Ser Ser Leu Ser Ala Ser Ile Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Thr Gln Ser Ile Ser Thr Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile
35 40 45
Tyr Ser Ala Ser His Leu Gln Arg Gly Val Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Thr Thr Leu Gln Pro
65 70 75 80
Glu Asp Val Gly Thr Tyr Tyr Cys His Gln Ser Tyr Gly Val Pro Ile
85 90 95
Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys
100 105
<210> 1472
<211> 109
<212> PRT
<213> Homo sapiens
<400> 1472
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Pro
85 90 95
Met Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1473
<211> 111
<212> PRT
<213> Homo sapiens
<400> 1473
Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys
1 5 10 15
Thr Val Thr Ile Ser Cys Thr Gly Ser Ser Gly Ser Ile Ala Ser Asn
20 25 30
Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ala Pro Thr Thr Val
35 40 45
Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly
65 70 75 80
Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser
85 90 95
Ser Lys Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1474
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1474
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser
20 25 30
Tyr Leu Gly Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
35 40 45
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65 70 75 80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro
85 90 95
Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1475
<211> 113
<212> PRT
<213> Homo sapiens
<400> 1475
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly
1 5 10 15
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser
20 25 30
Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Gln Leu Leu Ile Tyr Leu Gly Ser Thr Arg Ala Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala
85 90 95
Leu Gln Thr Pro Leu Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile
100 105 110
Lys
<210> 1476
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1476
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Cys Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Gly Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ser Leu Ser
85 90 95
Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys
100 105
<210> 1477
<211> 109
<212> PRT
<213> Homo sapiens
<400> 1477
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Asp Pro
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys His Lys Arg Ser Asn Trp Pro Pro
85 90 95
Ser Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1478
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1478
Ser Asn Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
1 5 10 15
Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Lys Gln Tyr Ala
20 25 30
Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr
35 40 45
Lys Asp Thr Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Ser Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Val Gln Ala Glu
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Thr Ala Ser Ser Gly Thr Tyr
85 90 95
Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1479
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1479
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Ser Pro
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1480
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1480
Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys
1 5 10 15
Thr Val Thr Phe Ser Cys Thr Gly Ser Ser Gly Ser Ile Ala Ser Asn
20 25 30
Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ala Pro Thr Thr Val
35 40 45
Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly
65 70 75 80
Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly
85 90 95
Ile Asn Arg Trp Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1481
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1481
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Gly
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1482
<211> 109
<212> PRT
<213> Homo sapiens
<400> 1482
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser
20 25 30
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
35 40 45
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65 70 75 80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro
85 90 95
Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1483
<211> 117
<212> PRT
<213> Homo sapiens
<400> 1483
Gln Pro Val Leu Thr Gln Pro Pro Ser Ala Ser Ala Ser Leu Gly Ala
1 5 10 15
Ser Val Thr Leu Thr Cys Thr Leu Ser Ser Gly Tyr Ser Asn Tyr Lys
20 25 30
Val Asp Trp Phe Gln Gln Arg Pro Gly Lys Gly Pro Arg Phe Val Met
35 40 45
Arg Val Gly Thr Gly Gly Ile Val Gly Ser Lys Gly Asp Gly Ile Pro
50 55 60
Asp Arg Phe Ser Val Leu Gly Ser Gly Leu Asn Arg Tyr Leu Thr Ile
65 70 75 80
Lys Asn Ile Gln Glu Glu Asp Glu Ser Asp Tyr His Cys Gly Ala Asp
85 90 95
His Gly Ser Gly Ser Asn Phe Val Tyr Val Val Phe Gly Gly Gly Thr
100 105 110
Lys Leu Thr Val Leu
115
<210> 1484
<211> 109
<212> PRT
<213> Homo sapiens
<400> 1484
Glu Val Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser
20 25 30
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
35 40 45
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65 70 75 80
Pro Glu Asp Phe Ala Val Tyr His Cys Gln His Phe Gly Ser Ser Ser
85 90 95
Gln Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1485
<211> 109
<212> PRT
<213> Homo sapiens
<400> 1485
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly
1 5 10 15
Thr Val Thr Leu Thr Cys Ala Ser Ser Thr Gly Ala Val Thr Ser Gly
20 25 30
Tyr Phe Pro Asn Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Arg Ala
35 40 45
Leu Ile Phe Ser Thr Asn Asn Arg His Ser Trp Thr Pro Ala Arg Phe
50 55 60
Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Leu Ser Gly Val
65 70 75 80
Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Leu Leu Tyr Tyr Gly Gly
85 90 95
Pro Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1486
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1486
Glu Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Val Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Leu Ser Ser Asn
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
65 70 75 80
Glu Asp Phe Ala Val Tyr His Cys Gln Gln Tyr Asn Asn Trp Pro Leu
85 90 95
Ala Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1487
<211> 111
<212> PRT
<213> Homo sapiens
<400> 1487
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Ile Gly Ser Tyr
20 25 30
Asn Leu Val Ser Trp Tyr Gln Gln Tyr Pro Gly Lys Ala Pro Lys Leu
35 40 45
Met Ile Tyr Glu Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Gly
85 90 95
Asn Thr Phe Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1488
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1488
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Arg
85 90 95
Thr Phe Gly Gln Gly Asn Arg Val Glu Ile Asn
100 105
<210> 1489
<211> 111
<212> PRT
<213> Homo sapiens
<400> 1489
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr
20 25 30
Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Ser Gly Ser Arg Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser
85 90 95
Ser Thr Pro Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1490
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1490
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly
1 5 10 15
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser
20 25 30
Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro His Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala
85 90 95
Leu Gln Thr Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105 110
<210> 1491
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1491
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Ala Ser Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Glu Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Trp
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1492
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1492
Gln Ser Val Leu Thr Gln Ala Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Arg Val Thr Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Ser Tyr
20 25 30
Thr Ile Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Gly Asn Asp Gln Arg Thr Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Lys Phe Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp Glu Asn Asn Tyr Tyr Cys Ala Val Trp Asp Asp Ser Leu
85 90 95
Asn Gly Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1493
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1493
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Asn Asn
20 25 30
Leu Ala Trp Tyr Gln His Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
65 70 75 80
Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Cys Tyr Asn Trp Pro Pro
85 90 95
Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1494
<211> 106
<212> PRT
<213> Homo sapiens
<400> 1494
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
1 5 10 15
Thr Ala Ser Ile Thr Cys Ser Gly Asp Lys Leu Gly Asp Lys Tyr Ala
20 25 30
Cys Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro Val Leu Val Ile Tyr
35 40 45
Gln Asp Ser Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Ser Thr Gly Val
85 90 95
Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105
<210> 1495
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1495
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Lys Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Leu Glu Arg Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Ala
65 70 75 80
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr His Asn Leu Pro Arg
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1496
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1496
Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Arg
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Ser Tyr Pro Phe
85 90 95
Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys
100 105
<210> 1497
<211> 113
<212> PRT
<213> Homo sapiens
<400> 1497
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser
20 25 30
Ser Asn Asn Lys Asn Ser Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
35 40 45
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln
85 90 95
Tyr Tyr Ser Ile Ser Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile
100 105 110
Lys
<210> 1498
<211> 111
<212> PRT
<213> Homo sapiens
<400> 1498
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr
20 25 30
Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Met Ile Tyr Asp Val Gly Asn Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser
85 90 95
Ser Thr Leu Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 1499
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1499
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Phe Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ile Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Val Ala Thr Tyr Tyr Cys Gln Lys Tyr Asn Ser Ala Pro Trp
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1500
<211> 106
<212> PRT
<213> Homo sapiens
<400> 1500
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
1 5 10 15
Thr Ala Ser Ile Thr Cys Ser Gly Asp Lys Leu Gly Asp Lys Phe Val
20 25 30
Cys Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr
35 40 45
Gln Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Leu
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Ser Thr Gly Val
85 90 95
Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1501
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1501
Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Met
35 40 45
Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Asn Thr Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Ser Tyr Pro Ile
85 90 95
Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys
100 105
<210> 1502
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1502
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Arg Val Thr Phe Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Ser Tyr
20 25 30
Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Asp Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Val Trp Asp Asp Ser Leu
85 90 95
Asn Gly Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1503
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1503
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln
1 5 10 15
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn
20 25 30
Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Tyr Asp Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser
50 55 60
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu
85 90 95
Asn Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1504
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1504
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Thr Ser Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Thr Thr Leu Leu
85 90 95
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1505
<211> 111
<212> PRT
<213> Homo sapiens
<400> 1505
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr
20 25 30
Asn Phe Val Ser Trp His Gln Gln His Pro Gly Lys Ala Pro Lys Asn
35 40 45
Met Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
His Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Thr
85 90 95
Ser Thr Pro Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1506
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1506
Glu Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Val Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Leu Ser Ser His
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Gly Val Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Ala Ile Ser Ser Leu Gln Ser
65 70 75 80
Glu Asp Ser Ala Val Tyr Tyr Cys Gln Gln Tyr His Val Trp Pro Pro
85 90 95
Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys
100 105
<210> 1507
<211> 113
<212> PRT
<213> Homo sapiens
<400> 1507
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser
20 25 30
Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
35 40 45
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln
85 90 95
Tyr Tyr Ser Thr Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile
100 105 110
Lys
<210> 1508
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1508
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Ser Phe Pro Leu
85 90 95
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1509
<211> 111
<212> PRT
<213> Homo sapiens
<400> 1509
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln
1 5 10 15
Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly
20 25 30
Tyr Asp Val His Trp Tyr Gln Gln Ile Pro Gly Thr Ala Pro Lys Leu
35 40 45
Leu Phe Tyr Gly Asn Asn Asn Arg Pro Ser Gly Val Pro Asp Arg Phe
50 55 60
Ser Asp Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser
85 90 95
Leu Ser Ala Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1510
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1510
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser His Ser Ile Ser Ser Trp
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Thr Tyr Ser Gln
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1511
<211> 109
<212> PRT
<213> Homo sapiens
<400> 1511
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro
85 90 95
Gly Val Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys
100 105
<210> 1512
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1512
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Arg Asn Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Glu Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Ile Phe Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Ile Ala Thr Tyr Tyr Cys His Gln Tyr Asp Tyr Leu Pro Tyr
85 90 95
Thr Phe Gly Gln Gly Thr Lys Leu Asp Ile Lys
100 105
<210> 1513
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1513
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Thr Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Tyr Ser Thr Pro Leu
85 90 95
Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1514
<211> 109
<212> PRT
<213> Homo sapiens
<400> 1514
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Phe
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Arg Pro Thr Gly Ile Pro Ala Arg Phe Thr Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Arg Thr Asn Trp Pro Pro
85 90 95
Leu Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys
100 105
<210> 1515
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1515
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
1 5 10 15
Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Asn Gln Tyr Ala
20 25 30
Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Met Cys
35 40 45
Lys Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Ser Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Val Gln Ala Glu
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Ala Asp Ser Ser Gly Thr Tyr
85 90 95
Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1516
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1516
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Thr Trp
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile
35 40 45
Tyr Glu Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Thr Tyr Ser Gly
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1517
<211> 117
<212> PRT
<213> Homo sapiens
<400> 1517
Gln Pro Val Leu Thr Gln Pro Pro Ser Ala Ser Ala Ser Leu Gly Ala
1 5 10 15
Ser Val Thr Leu Thr Cys Thr Leu Ser Ser Gly Tyr Ser Asn Tyr Lys
20 25 30
Val Asp Trp Tyr Gln Gln Arg Pro Gly Lys Gly Pro Arg Phe Val Met
35 40 45
Arg Val Gly Thr Gly Gly Ile Val Gly Ser Lys Gly Asp Gly Ile Pro
50 55 60
Asp Arg Phe Ser Val Leu Gly Ser Gly Leu Asn Arg Tyr Leu Thr Ile
65 70 75 80
Lys Asn Ile Gln Glu Glu Asp Glu Ser Asp Tyr His Cys Gly Ala Asp
85 90 95
His Gly Ser Gly Ser Asn Phe Val Phe Val Val Phe Gly Gly Gly Thr
100 105 110
Lys Leu Thr Val Leu
115
<210> 1518
<211> 113
<212> PRT
<213> Homo sapiens
<400> 1518
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Tyr Thr
20 25 30
Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
35 40 45
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln
85 90 95
Tyr Tyr Ser Pro Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile
100 105 110
Lys
<210> 1519
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1519
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr
20 25 30
Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr His Asn Leu Pro Pro
85 90 95
Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys
100 105
<210> 1520
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1520
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
1 5 10 15
Thr Ala Ser Ile Thr Cys Ser Gly Asp Lys Leu Gly Glu Thr Tyr Val
20 25 30
Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr
35 40 45
Glu Asp Ser Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Ser Thr Gly Gly
85 90 95
Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105
<210> 1521
<211> 111
<212> PRT
<213> Homo sapiens
<400> 1521
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Leu Asp Ile Ser Lys Tyr
20 25 30
Leu Asn Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile
35 40 45
Tyr Asp Ala Phe Asn Leu Glu Arg Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Pro
85 90 95
Gly Val Ser Thr Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys
100 105 110
<210> 1522
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1522
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
1 5 10 15
Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Lys Lys Tyr Ala
20 25 30
His Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Val Leu Val Ile Tyr
35 40 45
Glu Asp Ser Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Ser Ser Gly Thr Met Ala Thr Leu Thr Ile Ser Gly Ala Gln Val Glu
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Thr Asp Ser Ser Gly Asn Gln
85 90 95
Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1523
<211> 111
<212> PRT
<213> Homo sapiens
<400> 1523
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Ile Gly Gly Tyr
20 25 30
Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Leu Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Thr Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser
85 90 95
Ser Thr His Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1524
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1524
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
1 5 10 15
Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Arg Gln Tyr Thr
20 25 30
Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr
35 40 45
Lys Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Ser Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Val Gln Ala Glu
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Ala Asp Thr Ile Gly Thr Tyr
85 90 95
Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1525
<211> 109
<212> PRT
<213> Homo sapiens
<400> 1525
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Val Ser Val Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Ala
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Pro
85 90 95
Met Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1526
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1526
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Thr Asn Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Tyr Ser
85 90 95
Val His Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1527
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1527
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Lys Ser Gly Val Pro Ser Arg Phe Gly Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Glu Met Pro Pro
85 90 95
Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Glu
100 105
<210> 1528
<211> 106
<212> PRT
<213> Homo sapiens
<400> 1528
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
1 5 10 15
Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Asn Gln Tyr Ala
20 25 30
Tyr Trp Tyr His Gln Lys Pro Gly Gln Ala Pro Val Val Val Ile Tyr
35 40 45
Lys Asp Ser Glu Arg Pro Ser Gly Ile Pro Gln Arg Phe Ser Gly Ser
50 55 60
Ser Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Val Gln Ala Glu
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Ala Asp Ser Ser Gly Tyr Val
85 90 95
Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105
<210> 1529
<211> 111
<212> PRT
<213> Homo sapiens
<400> 1529
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr
20 25 30
Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Met Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser
85 90 95
Ser Ile Pro Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 1530
<211> 106
<212> PRT
<213> Homo sapiens
<400> 1530
Glu Ile Val Leu Thr Gln Ser Pro Ala Ile Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Asp Thr Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro
65 70 75 80
Glu Asp Phe Ala Phe Tyr Tyr Cys Gln Gln Arg Gly Asn Trp Trp Thr
85 90 95
Phe Ala Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1531
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1531
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Arg Gln
1 5 10 15
Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Lys Lys Tyr Ala
20 25 30
Tyr Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Val Leu Val Ile Tyr
35 40 45
Glu Asp Ser Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Ser Ser Gly Thr Met Ala Thr Leu Thr Ile Ser Gly Ala Gln Val Glu
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Tyr Ser Thr Asp Thr Ser Gly Asn His
85 90 95
Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1532
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1532
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
1 5 10 15
Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Lys Lys Tyr Ala
20 25 30
Tyr Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Val Leu Val Ile Ser
35 40 45
Glu Asp Ser Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Ser Ser Gly Thr Val Ala Thr Leu Thr Ile Ser Gly Ala Gln Val Glu
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Tyr Ser Thr Asp Ser Ser Gly Asn His
85 90 95
Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1533
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1533
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Thr
20 25 30
Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
35 40 45
Ile Phe Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65 70 75 80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Tyr Gly Thr Ser Pro
85 90 95
Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1534
<211> 106
<212> PRT
<213> Homo sapiens
<400> 1534
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
1 5 10 15
Glu Arg Val Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Gly Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Phe Leu Thr
85 90 95
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1535
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1535
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser
20 25 30
Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
35 40 45
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln
85 90 95
Tyr Tyr Ser Thr Pro Gly Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 1536
<211> 111
<212> PRT
<213> Homo sapiens
<400> 1536
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln
1 5 10 15
Arg Val Thr Leu Ser Cys Thr Gly Ser Asn Ser Asn Ile Gly Ala Gly
20 25 30
Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu
35 40 45
Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser
85 90 95
Leu Ser Asp Ser Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 1537
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1537
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
1 5 10 15
Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Asn Gln Tyr Ala
20 25 30
Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr
35 40 45
Lys Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Ser Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Val Gln Ala Glu
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Ala Asp Ser Ser Gly Thr Ser
85 90 95
Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1538
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1538
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Ser Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser
20 25 30
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
35 40 45
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65 70 75 80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro
85 90 95
Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1539
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1539
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Arg Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Lys Ala Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Ser Leu
85 90 95
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1540
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1540
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
65 70 75 80
Glu Asp Phe Ala Leu Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Trp Arg
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Asn
100 105
<210> 1541
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1541
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
1 5 10 15
Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Lys Lys Tyr Ala
20 25 30
Tyr Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Val Leu Val Ile Tyr
35 40 45
Glu Asp Ser Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Ser Ser Gly Thr Met Ala Thr Leu Thr Ile Ser Gly Ala Gln Val Glu
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Tyr Ser Thr Asp Ser Ser Gly Asn His
85 90 95
Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1542
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1542
Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln
1 5 10 15
Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala
20 25 30
Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Leu Leu Val Ile Tyr
35 40 45
Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser
50 55 60
Ser Ser Gly Asn Thr Pro Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Asn Phe Arg Asp Ser Ser Gly His His
85 90 95
Pro Val Phe Gly Glu Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1543
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1543
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Arg Val Ile Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn
20 25 30
Thr Val Lys Trp Tyr His Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
35 40 45
Ile Cys Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Lys Ser Asp Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu
85 90 95
Asn Ala Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1544
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1544
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Gly
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1545
<211> 106
<212> PRT
<213> Homo sapiens
<400> 1545
Ser Tyr Glu Leu Thr Gln Pro Ser Ser Val Ser Val Ser Pro Gly Gln
1 5 10 15
Thr Ala Arg Ile Thr Cys Ser Gly Asp Val Leu Ala Lys Asn Tyr Ala
20 25 30
Arg Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr
35 40 45
Lys Asp Ser Glu Arg Pro Ser Gly Ile Pro Lys Arg Phe Ser Gly Ser
50 55 60
Ser Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Ala Gln Val Glu
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Tyr Ser Ala Ala Asp Asn Asn Arg Val
85 90 95
Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1546
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1546
Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln
1 5 10 15
Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala
20 25 30
Ser Trp Tyr Gln Gln Lys Pro Gly Gln Val Pro Ile Leu Val Ile Tyr
35 40 45
Asp Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser
50 55 60
Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn Ala
85 90 95
Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1547
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1547
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Ser
20 25 30
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Leu Leu
85 90 95
Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys
100 105
<210> 1548
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1548
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro
85 90 95
Arg Thr Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105 110
<210> 1549
<211> 109
<212> PRT
<213> Homo sapiens
<400> 1549
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Phe
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys His Tyr Arg Ser Asn Trp Pro Pro
85 90 95
Val Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Glu
100 105
<210> 1550
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1550
Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln
1 5 10 15
Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala
20 25 30
Ser Trp Tyr Gln Gln Lys Pro Gly Gln Val Pro Ile Leu Val Ile Tyr
35 40 45
Asp Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser
50 55 60
Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn Ala
85 90 95
Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Ala
100 105
<210> 1551
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1551
Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln
1 5 10 15
Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala
20 25 30
Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Val Val Ile Phe
35 40 45
Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser
50 55 60
Asn Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Tyr Ile
85 90 95
Trp Gly Trp Met Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1552
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1552
Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys
1 5 10 15
Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val
20 25 30
His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Val Val Val Tyr
35 40 45
Asp Asp Ser Asp Arg Pro Ser Gly Leu Pro Glu Arg Phe Ser Gly Ser
50 55 60
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp His
85 90 95
Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1553
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1553
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln
1 5 10 15
Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly
20 25 30
Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu
35 40 45
Leu Ile Phe Ile Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser
85 90 95
Leu Gly Ala Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1554
<211> 111
<212> PRT
<213> Homo sapiens
<400> 1554
Gln Leu Val Leu Thr Gln Ser Pro Ser Ala Ser Ala Ser Leu Gly Ala
1 5 10 15
Ser Val Lys Leu Thr Cys Thr Leu Ser Ser Gly His Thr Thr Tyr Ala
20 25 30
Ile Ala Trp His Gln Gln Gln Pro Glu Lys Gly Pro Arg Tyr Leu Met
35 40 45
Lys Leu Asn Ser Asp Gly Ser His Thr Arg Gly Asp Gly Ile Pro Asp
50 55 60
Arg Phe Ser Gly Ser Ser Ser Gly Ala Glu Arg Tyr Leu Thr Ile Ser
65 70 75 80
Ser Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Trp Asp
85 90 95
Thr Gly Ile Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1555
<211> 106
<212> PRT
<213> Homo sapiens
<400> 1555
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
1 5 10 15
Thr Ala Ser Ile Thr Cys Phe Gly Asp Lys Leu Gly Asp Lys Tyr Ala
20 25 30
Cys Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Ile Ile Tyr
35 40 45
Gln Gly Ala Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Ser Thr Val Val
85 90 95
Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1556
<211> 111
<212> PRT
<213> Homo sapiens
<400> 1556
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr
20 25 30
Asn Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Met Ile Tyr Glu Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Val Gly Ser
85 90 95
Ser Thr Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1557
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1557
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
1 5 10 15
Thr Ala Arg Ile Thr Cys Ser Ala Asp Ala Leu Ser Lys Gln Tyr Ala
20 25 30
Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Val Val Ile Tyr
35 40 45
Lys Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Ser Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Val Gln Ala Glu
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Ala Asp Ser Ser Ser His Trp
85 90 95
Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1558
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1558
Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys
1 5 10 15
Thr Val Thr Ile Ser Cys Thr Gly Asn Ser Gly Ser Ile Ala Ser Asn
20 25 30
Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ala Pro Thr Thr Val
35 40 45
Ile Tyr Glu Asp Ser Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly
65 70 75 80
Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Phe Asp Ser
85 90 95
Gly Asn Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1559
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1559
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn
20 25 30
Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Asn Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Leu Ser
50 55 60
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Val Ala Trp Asp Asp Ser Arg
85 90 95
Asn Gly Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1560
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1560
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser
20 25 30
Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
35 40 45
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln
85 90 95
Tyr Tyr Ser Thr Arg Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 1561
<211> 114
<212> PRT
<213> Homo sapiens
<400> 1561
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser
20 25 30
Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
35 40 45
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln
85 90 95
Tyr Tyr Ser Thr Pro Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu
100 105 110
Ile Lys
<210> 1562
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1562
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Arg Val Thr Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Ser Tyr
20 25 30
Thr Val Asn Trp Tyr Gln Gln Phe Pro Gly Thr Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Asp Asn Asn Gln Arg Thr Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp Glu Ala Ser Tyr Tyr Cys Leu Ala Trp Asp Asp Ser Leu
85 90 95
Asn Gly Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1563
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1563
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn
20 25 30
Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Ser Ser Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg
65 70 75 80
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Ala Ser Leu
85 90 95
Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1564
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1564
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
1 5 10 15
Thr Ala Arg Ile Thr Cys Ser Ala Asp Ala Leu Pro Lys His Tyr Ala
20 25 30
Tyr Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Val Leu Val Ile Tyr
35 40 45
Lys Asp Ile Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Ser Ser Gly Thr Thr Val Thr Leu Thr Ile Thr Gly Ala Gln Ala Glu
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Val Asp Gly Ser Gly Ser Ser
85 90 95
Val Val Phe Gly Gly Gly Thr Lys Leu Ala Val Leu
100 105
<210> 1565
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1565
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
1 5 10 15
Thr Ala Ser Ile Thr Cys Ser Gly Asp Lys Leu Gly Asp Lys Tyr Ala
20 25 30
Cys Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile His
35 40 45
Gln Asp Ser Gln Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Ser Thr His Val
85 90 95
Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1566
<211> 111
<212> PRT
<213> Homo sapiens
<400> 1566
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr
20 25 30
Asn Tyr Val Ser Trp Phe Gln His His Pro Asp Lys Ala Pro Arg Leu
35 40 45
Met Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser
85 90 95
Ser Thr Pro Phe Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 1567
<211> 111
<212> PRT
<213> Homo sapiens
<400> 1567
Gln Pro Val Leu Thr Gln Ser Ser Ser Ala Ser Ala Ser Leu Gly Ser
1 5 10 15
Ser Val Lys Leu Thr Cys Thr Leu Ser Ser Gly His Ser Ser Tyr Ile
20 25 30
Ile Ala Trp His Gln Gln Gln Pro Gly Lys Ala Pro Arg Tyr Leu Met
35 40 45
Lys Leu Glu Gly Ser Gly Ser Tyr Asn Lys Gly Ser Gly Val Pro Asp
50 55 60
Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Cys Tyr Leu Thr Ile Ser
65 70 75 80
Asn Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Glu Thr Trp Asp
85 90 95
Ser Asn Thr Arg Val Phe Ala Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1568
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1568
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Phe Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Met
85 90 95
His Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1569
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1569
Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Ser Tyr Leu Gly
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1570
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1570
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Pro
85 90 95
Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys
100 105
<210> 1571
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1571
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Arg Val Thr Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Ser Tyr
20 25 30
Thr Val Asn Trp Tyr Gln Gln Phe Pro Gly Thr Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Asp Asn Asn Gln Arg Thr Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp Glu Ala Asn Tyr Tyr Cys Leu Val Trp Asp Asp Ser Leu
85 90 95
Asn Gly Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1572
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1572
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr
20 25 30
Asn Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Met Ile Tyr Glu Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Ser
85 90 95
Ser Thr Trp Gly Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 1573
<211> 109
<212> PRT
<213> Homo sapiens
<400> 1573
Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys
1 5 10 15
Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Thr Lys Gly Val
20 25 30
His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr
35 40 45
Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Gly Arg Phe Ser Gly Ser
50 55 60
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly
65 70 75 80
Asp Glu Ala Asp Tyr Phe Cys Gln Val Trp Asp Ser Ser Ser Asp His
85 90 95
His Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1574
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1574
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly
1 5 10 15
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser
20 25 30
Asp Gly Tyr Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Gln Leu Leu Ile Tyr Leu Gly Ser Lys Arg Ala Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala
85 90 95
Leu Gln Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105 110
<210> 1575
<211> 109
<212> PRT
<213> Homo sapiens
<400> 1575
Glu Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Val Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Gly Ala Ser Thr Arg Ala Thr Gly Val Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Pro
85 90 95
Met Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1576
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1576
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Arg
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1577
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1577
Gln Pro Val Val Thr Gln Ser Pro Ser Ala Ser Ala Ser Leu Gly Ala
1 5 10 15
Ser Val Lys Leu Thr Cys Thr Leu Asp Ser Gly His Arg Ser Tyr Ala
20 25 30
Ile Ala Trp His Gln Gln Arg Pro Glu Lys Gly Pro Arg Phe Leu Met
35 40 45
Arg Ile Thr Thr Asp Gly Arg His Thr Lys Gly Asp Gly Ile Pro Asp
50 55 60
Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Arg Tyr Leu Thr Ile Ser
65 70 75 80
Ser Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Thr Trp Gly
85 90 95
Thr Phe Gly Gly Gly Thr Arg Leu Thr Val Leu
100 105
<210> 1578
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1578
Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly
1 5 10 15
Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu His Ser
20 25 30
Asp Gly Lys Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Gln Leu Leu Ile Tyr Glu Val Ser Asn Arg Phe Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ser
85 90 95
Ile Gln Pro Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105 110
<210> 1579
<211> 113
<212> PRT
<213> Homo sapiens
<400> 1579
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser
20 25 30
Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
35 40 45
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln
85 90 95
Tyr Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile
100 105 110
Lys
<210> 1580
<211> 111
<212> PRT
<213> Homo sapiens
<400> 1580
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Leu Ile Thr Ile Phe Cys Asn Gly Ser Ile Ser Asp Val Gly Gly Trp
20 25 30
Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Asp Lys Ala Pro Lys Met
35 40 45
Met Ile Tyr Asp Val Arg His Arg Pro Ser Gly Val Ser Ser Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Gly Asp Tyr Tyr Cys Ser Ser Phe Thr Ser Arg
85 90 95
Gly Ala Leu Val Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1581
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1581
Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr
20 25 30
Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Met Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Ile
85 90 95
Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1582
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1582
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser
20 25 30
Tyr Leu Gly Trp Tyr His Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
35 40 45
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65 70 75 80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Tyr Gly Ser Ser Arg
85 90 95
Ser Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1583
<211> 106
<212> PRT
<213> Homo sapiens
<400> 1583
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Arg Gln Ser Ile Ser Asn Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Thr
85 90 95
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1584
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1584
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Tyr
85 90 95
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1585
<211> 109
<212> PRT
<213> Homo sapiens
<400> 1585
Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln
1 5 10 15
Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala
20 25 30
Ser Trp Tyr Gln Gln Lys Pro Arg Gln Ala Pro Val Leu Ile Ile Ser
35 40 45
Gly Asn Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser
50 55 60
Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His
85 90 95
Leu Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1586
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1586
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn
20 25 30
Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
35 40 45
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65 70 75 80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Arg Ser Pro
85 90 95
Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys
100 105
<210> 1587
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1587
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Leu Gln
85 90 95
Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys
100 105
<210> 1588
<211> 106
<212> PRT
<213> Homo sapiens
<400> 1588
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
1 5 10 15
Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Thr Lys Tyr Ala
20 25 30
Tyr Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Val Leu Val Ile Tyr
35 40 45
Asp Asp Ser Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Ser Ser Gly Thr Met Ala Thr Leu Thr Ile Ser Gly Ala Gln Val Glu
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Tyr Ser Thr Asp Ser Ser Gly Asn Val
85 90 95
Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105
<210> 1589
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1589
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Ala Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Ser Asn
20 25 30
Leu Ala Trp Tyr His Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Ser Leu
85 90 95
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1590
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1590
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser
20 25 30
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
35 40 45
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65 70 75 80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Tyr Tyr Gly Ser Ser Pro
85 90 95
Phe Gly Phe Gly Pro Gly Thr Lys Val Asp Ile Lys
100 105
<210> 1591
<211> 109
<212> PRT
<213> Homo sapiens
<400> 1591
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Arg Phe
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro
85 90 95
Arg Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1592
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1592
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn
20 25 30
Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp Glu Asn Asn Tyr Tyr Cys Ala Val Trp Asp Asp Ser Leu
85 90 95
Asn Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1593
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1593
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn
20 25 30
Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
35 40 45
Ile Ser Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp Glu Ala Asn Tyr Tyr Cys Leu Val Trp Asp Asp Ser Leu
85 90 95
Asn Gly Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1594
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1594
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr
20 25 30
Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Cys Cys Ser Ser Tyr Thr Ser Ser
85 90 95
Arg Ala Val Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1595
<211> 113
<212> PRT
<213> Homo sapiens
<400> 1595
Asp Phe Val Met Thr Gln Ser Pro Gly Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Glu Arg Ala Thr Ile Asn Cys Arg Ser Ser Gln Ser Val Leu Asp Asn
20 25 30
Ser Ser Asn Lys Asn His Leu Ala Trp His Gln Gln Lys Pro Gly Gln
35 40 45
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln
85 90 95
Tyr Tyr Ser Ser His Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile
100 105 110
Lys
<210> 1596
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1596
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr
20 25 30
Asn Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Met Ile Tyr Glu Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Tyr Ser Tyr Ala Gly Ser
85 90 95
Ser Thr Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1597
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1597
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
1 5 10 15
Thr Ala Arg Ile Thr Cys Ser Ala Asp Ala Leu Pro Lys Gln Tyr Ala
20 25 30
Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr
35 40 45
Lys Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Ser Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Val Gln Ala Glu
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Thr Asp Ser Ser Gly Ser Tyr
85 90 95
Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1598
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1598
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Ala Ser Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Glu Phe Ala Thr Tyr Tyr Cys His Gln Ser Tyr Phe Thr Pro Gln
85 90 95
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1599
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1599
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ala Leu Ser Val Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Val Ala Ser Gln Arg Val Ser Ser Asp
20 25 30
Tyr Ile Ala Trp Tyr Gln Lys Lys Pro Gly Leu Ala Pro Arg Leu Leu
35 40 45
Val Tyr His Gly Ser Ala Trp Ala Thr Gly Ser Ser Ala Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Thr Ile Ser Ser Leu Glu
65 70 75 80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Asn Ser Pro
85 90 95
Phe Thr Phe Gly Pro Gly Thr Lys Val Glu Phe Lys
100 105
<210> 1600
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1600
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser
20 25 30
Tyr Leu Ala Trp Tyr Gln Glu Lys Pro Gly Gln Ala Pro Arg Leu Leu
35 40 45
Met Tyr Ser Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gly Ser Ala Thr Asp Phe Thr Leu Thr Ile Asn Arg Leu Glu
65 70 75 80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Val Glu Pro Pro
85 90 95
Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1601
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1601
Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr
20 25 30
Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Met Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Glu Tyr Tyr Cys Ser Ala Tyr Ala Gly Ser
85 90 95
Asn Asn Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1602
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1602
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Gly Gln Thr Val Ser Ser Ser
20 25 30
Tyr Leu Ala Trp Tyr Gln His Lys Pro Gly Gln Ala Pro Arg Leu Leu
35 40 45
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65 70 75 80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Tyr
85 90 95
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1603
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1603
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Tyr Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Gly
85 90 95
Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys
100 105
<210> 1604
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1604
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser
20 25 30
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
35 40 45
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65 70 75 80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Arg Ser Ser
85 90 95
Gly Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1605
<211> 109
<212> PRT
<213> Homo sapiens
<400> 1605
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser
20 25 30
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
35 40 45
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65 70 75 80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro
85 90 95
Leu Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys
100 105
<210> 1606
<211> 113
<212> PRT
<213> Homo sapiens
<400> 1606
Asp Ile Val Met Thr Gln Ser Pro Asp Phe Leu Ala Val Ser Leu Gly
1 5 10 15
Glu Arg Ala Thr Ile Ser Cys Lys Ser Ser Gln Ser Val Leu Tyr Thr
20 25 30
Pro Lys Asn Lys Asn Tyr Leu Ala Trp Tyr Lys Gln Lys Pro Gly Gln
35 40 45
Pro Pro Lys Val Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Ile
65 70 75 80
Ile Ser Ser Leu Gln Ala Glu Asp Ala Ala Val Tyr Tyr Cys Gln Gln
85 90 95
Tyr Tyr Thr Ala Pro Leu Thr Phe Gly Gly Gly Thr Arg Val Glu Ile
100 105 110
Lys
<210> 1607
<211> 109
<212> PRT
<213> Homo sapiens
<400> 1607
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly
1 5 10 15
Thr Val Thr Leu Thr Cys Ala Ser Ser Ala Gly Ala Val Thr Ser Gly
20 25 30
Tyr Tyr Pro Asn Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Arg Ala
35 40 45
Leu Ile Tyr Ser Thr Ala Asn Lys His Ser Trp Thr Pro Ala Arg Phe
50 55 60
Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val
65 70 75 80
Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Leu Leu Tyr Tyr Gly Gly
85 90 95
Ala Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1608
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1608
Glu Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
1 5 10 15
Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Gly Ser Ser
20 25 30
Leu His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Val Ile Ile
35 40 45
Lys Tyr Ala Ser Gln Ser Phe Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Ala
65 70 75 80
Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Ser Ser Ser Leu Pro Pro
85 90 95
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1609
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1609
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Ser Phe
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Arg Arg Ser Asn Trp Pro Pro
85 90 95
Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys
100 105
<210> 1610
<211> 111
<212> PRT
<213> Homo sapiens
<400> 1610
Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys
1 5 10 15
Thr Val Thr Ile Ser Cys Thr Gly Ser Ser Gly Ser Ile Ala Ser Asn
20 25 30
Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ala Pro Thr Thr Val
35 40 45
Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly
65 70 75 80
Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser
85 90 95
Ser Asn Tyr Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1611
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1611
Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln
1 5 10 15
Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala
20 25 30
Ser Trp Tyr Gln Gln Lys Pro Gly Gln Val Pro Ile Leu Val Ile Tyr
35 40 45
Asp Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser
50 55 60
Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn Ala
85 90 95
Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1612
<211> 113
<212> PRT
<213> Homo sapiens
<400> 1612
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser
20 25 30
Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
35 40 45
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln
85 90 95
Tyr Tyr Ser Ser Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile
100 105 110
Lys
<210> 1613
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1613
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser
20 25 30
Tyr Leu Gly Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
35 40 45
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65 70 75 80
Ser Glu Asp Phe Ala Leu Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Trp
85 90 95
Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1614
<211> 109
<212> PRT
<213> Homo sapiens
<400> 1614
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser
20 25 30
Tyr Leu Ala Trp Tyr Gln Gln Lys Arg Gly Gln Ala Pro Arg Leu Leu
35 40 45
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65 70 75 80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro
85 90 95
Arg Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1615
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1615
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Arg Val Thr Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Ser Tyr
20 25 30
Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Asp Asn Asn Gln Arg Thr Ser Gly Val Pro Asp Arg Leu Ser
50 55 60
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp Glu Ala Asn Tyr Tyr Cys Ala Val Trp Asp Asp Ser Leu
85 90 95
Asn Gly Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1616
<211> 111
<212> PRT
<213> Homo sapiens
<400> 1616
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln
1 5 10 15
Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly
20 25 30
Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu
35 40 45
Leu Ile Phe Gly Asn Thr Asn Arg Pro Ser Gly Val Pro Asp Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Thr Ser Thr Ser Leu Ala Ile Thr Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser
85 90 95
Leu Asn Gly Asp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1617
<211> 109
<212> PRT
<213> Homo sapiens
<400> 1617
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Asp Ala Tyr Lys Arg Asp Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Leu
85 90 95
Ile Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys
100 105
<210> 1618
<211> 111
<212> PRT
<213> Homo sapiens
<400> 1618
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Val Pro Gly Gln
1 5 10 15
Arg Val Thr Val Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly
20 25 30
Phe Asp Val Tyr Trp Tyr Gln Gln Phe Leu Gly Thr Ala Pro Lys Leu
35 40 45
Leu Ile Tyr Gly Asn Asn Asn Arg Pro Ser Gly Val Pro Asp Arg Phe
50 55 60
Ser Ala Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser
85 90 95
Leu Ser Gly Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 1619
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1619
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro
85 90 95
Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys
100 105
<210> 1620
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1620
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Thr Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Arg Ser Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Val Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro
85 90 95
Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1621
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1621
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ala Asn Leu Pro Phe
85 90 95
Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys
100 105
<210> 1622
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1622
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Arg Val Thr Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Ser Tyr
20 25 30
Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
35 40 45
Ile Phe Gly Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Val Ala Trp Asp Asp Ser Arg
85 90 95
Asn Gly Leu Val Phe Gly Gly Gly Ala Lys Leu Thr Val Leu
100 105 110
<210> 1623
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1623
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
1 5 10 15
Thr Ala Arg Ile Thr Cys Ser Thr Asp Ala Leu Pro Asn Glu Tyr Ile
20 25 30
Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr
35 40 45
Lys Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Ser Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Val Gln Ala Glu
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Val Asp Ser Ser Gly Thr Tyr
85 90 95
Pro His Val Ile Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1624
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1624
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ile Ser Tyr
20 25 30
Leu Asn Trp Tyr His Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Tyr
85 90 95
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1625
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1625
Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Ser Tyr Pro Leu
85 90 95
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1626
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1626
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr
20 25 30
Asn Phe Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Ile Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Thr Ser Tyr Thr Ser Ser
85 90 95
Ser Thr Leu Asn Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1627
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1627
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr
20 25 30
Asn Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Met Ile Tyr Glu Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Ser Ser
85 90 95
Ser Ile Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1628
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1628
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Leu
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro
85 90 95
Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1629
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1629
Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Ser Tyr Ser Phe
85 90 95
Glu Thr Phe Gly Pro Gly Thr Lys Val Ala Ile Lys
100 105
<210> 1630
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1630
Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys
1 5 10 15
Thr Val Thr Phe Ser Cys Thr Gly Ser Ser Gly Ser Ile Ala Ser Asn
20 25 30
Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ala Pro Thr Thr Val
35 40 45
Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly
65 70 75 80
Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly
85 90 95
Ile Asn Arg Trp Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1631
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1631
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Ile Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp
20 25 30
Leu Ala Trp Tyr Gln Gln Ile Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr
85 90 95
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1632
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1632
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Ile Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Arg Ser Tyr
20 25 30
Leu Asn Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Glu Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Ser Ser Ser Pro Ile
85 90 95
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1633
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1633
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asn Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Ser Cys Gln Gln Ser Tyr Thr Thr Leu Leu
85 90 95
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1634
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1634
Ser Tyr Glu Leu Ala Gln Pro Pro Ser Val Ser Val Ala Pro Gly Glu
1 5 10 15
Thr Ala Thr Ile Phe Cys Arg Ala Thr Tyr Ile Gly Arg Lys Asn Val
20 25 30
Gln Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr
35 40 45
Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Gly Arg Phe Ser Gly Ser
50 55 60
Asn Ser Gly Asp Thr Ala Thr Leu Thr Ile Ser Arg Ile Glu Ala Gly
65 70 75 80
Asp Glu Ala Ala Tyr Tyr Cys Gln Val Trp Asp Gly Ile Asn Asp Arg
85 90 95
Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1635
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1635
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Asn Asn Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Leu Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Pro
85 90 95
Val Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1636
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1636
Asp Phe Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Thr Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile
35 40 45
Phe Ala Ala Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ser Glu Trp
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1637
<211> 111
<212> PRT
<213> Homo sapiens
<400> 1637
Gln Ser Leu Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln
1 5 10 15
Arg Val Thr Leu Ser Cys Ala Gly Ala Thr Ser Asn Ile Gly Ala Gly
20 25 30
Ser Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu
35 40 45
Leu Ile Tyr Tyr Asn Thr Asn Arg Pro Ser Gly Val Pro Asp Arg Phe
50 55 60
Ser Gly Ser Lys Ser Ala Thr Ser Ala Ser Leu Val Ile Thr Gly Leu
65 70 75 80
Gln Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ile Ser
85 90 95
Leu Gly Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1638
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1638
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ile Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Val Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Met Pro Pro
85 90 95
Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys
100 105
<210> 1639
<211> 111
<212> PRT
<213> Homo sapiens
<400> 1639
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn
20 25 30
Ser Leu Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu
85 90 95
Asn Gly Ser Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1640
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1640
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Arg Val Thr Ile Ser Cys Ser Gly Ser Arg Tyr Asn Ile Gly Ser Asn
20 25 30
Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Arg Leu Leu
35 40 45
Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg
65 70 75 80
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu
85 90 95
Ser Gly Leu Ile Phe Gly Gly Gly Thr Lys Leu Thr Val Gln
100 105 110
<210> 1641
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1641
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr
20 25 30
Asn Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Met Ile Tyr Glu Gly Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Ser
85 90 95
Ser Thr Trp Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1642
<211> 109
<212> PRT
<213> Homo sapiens
<400> 1642
Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys
1 5 10 15
Thr Ala Arg Ile Thr Cys Glu Gly Asn Asn Ile Gly Ser Lys Ser Val
20 25 30
His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr
35 40 45
Asp Asp Ser Gly Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly
65 70 75 80
Asp Glu Ala Asp Tyr Phe Cys Gln Val Trp Asp Ser Ser Ser Asp His
85 90 95
His Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1643
<211> 111
<212> PRT
<213> Homo sapiens
<400> 1643
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln
1 5 10 15
Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly
20 25 30
Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Glu Thr Ala Pro Lys Leu
35 40 45
Leu Ile Tyr Ala Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu
65 70 75 80
Gln Ser Glu Ala Glu Ala Asp Tyr Tyr Cys Val Ala Trp Asp Asp Ser
85 90 95
Arg Asn Gly Leu Val Phe Gly Gly Gly Ala Lys Leu Thr Val Leu
100 105 110
<210> 1644
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1644
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln
1 5 10 15
Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn
20 25 30
Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Asp Asn Asn Glu Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln
65 70 75 80
Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu
85 90 95
Ser Ala Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 1645
<211> 109
<212> PRT
<213> Homo sapiens
<400> 1645
Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys
1 5 10 15
Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Asn Lys Gly Val
20 25 30
His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Asp
35 40 45
Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Asn Ser Gly Asn Thr Ala Thr Leu Ile Ile Ser Ser Val Glu Val Gly
65 70 75 80
Asp Glu Ala Asp Phe Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp His
85 90 95
Pro Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1646
<211> 106
<212> PRT
<213> Homo sapiens
<400> 1646
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
1 5 10 15
Thr Ala Ser Ile Thr Cys Ser Gly Asp Lys Leu Gly Asp Lys Tyr Ala
20 25 30
Cys Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr
35 40 45
Gln Asp Thr Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Gly Ser Ser Arg Gly Val
85 90 95
Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1647
<211> 109
<212> PRT
<213> Homo sapiens
<400> 1647
Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln
1 5 10 15
Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala
20 25 30
Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Val Val Ile Tyr
35 40 45
Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser
50 55 60
Ser Ser Gly Asn Lys Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Gly
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Asn Ser Gly Asn Leu
85 90 95
Asn Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1648
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1648
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Asn Asn Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Ser Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Asn Ser Leu Gln Pro
65 70 75 80
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Tyr
85 90 95
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1649
<211> 106
<212> PRT
<213> Homo sapiens
<400> 1649
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
1 5 10 15
Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Lys Gln Tyr Ala
20 25 30
Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr
35 40 45
Lys Asp Thr Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Ser Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Val Gln Ala Glu
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Ala Asp Ser Ser Gly Ser Arg
85 90 95
Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1650
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1650
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Gly Ala Ser Thr Arg Ala Thr Val Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Tyr
85 90 95
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1651
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1651
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Glu Ile Pro Pro
85 90 95
Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1652
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1652
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn
20 25 30
Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Asn Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Leu Ser
50 55 60
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1653
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1653
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln
1 5 10 15
Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ser Gly
20 25 30
Ser Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu
35 40 45
Leu Ile Tyr Gly Asn Thr Asn Arg Pro Ser Gly Val Pro Asp Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Arg
85 90 95
Leu Ser Gly Phe Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1654
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1654
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
1 5 10 15
Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Lys Gln Tyr Ala
20 25 30
Tyr Trp Tyr His Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr
35 40 45
Lys Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Ser Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Val Gln Ala Glu
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Ala Asp Ser Ser Gly Thr Ser
85 90 95
Val Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1655
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1655
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr
20 25 30
Asn Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Met Ile Tyr Glu Gly Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Arg Ser
85 90 95
Ser Thr Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1656
<211> 106
<212> PRT
<213> Homo sapiens
<400> 1656
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
1 5 10 15
Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Phe Pro Lys Gln Tyr Gly
20 25 30
Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr
35 40 45
Lys Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Ser Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Val Gln Ala Glu
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Ala Asp Ser Arg Gly Ala Val
85 90 95
Phe Gly Ser Gly Thr Lys Val Thr Val Leu
100 105
<210> 1657
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1657
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Ser Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn
20 25 30
Lys Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Val Leu
35 40 45
Ile Tyr Asn Ser Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Val Trp Asp Asp Ser Leu
85 90 95
His Ser Tyr Val Phe Gly Thr Glu Thr Lys Val Thr Val Leu
100 105 110
<210> 1658
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1658
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Arg Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Thr Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Arg
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1659
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1659
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asn Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Asp Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Leu
85 90 95
Ala Phe Gly Pro Gly Thr Lys Val Asp Ile Lys
100 105
<210> 1660
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1660
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asn Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Ser Cys Gln Gln Ser Tyr Thr Thr Leu Leu
85 90 95
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1661
<211> 111
<212> PRT
<213> Homo sapiens
<400> 1661
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln
1 5 10 15
Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Arg
20 25 30
Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu
35 40 45
Leu Met Tyr Gly Asn Asn Asn Arg Pro Ser Gly Val Pro Asp Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Thr Ser Val Ser Leu Ala Ile Thr Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser
85 90 95
Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1662
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1662
Val Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Asn Lys Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ala Asn Leu Pro Phe
85 90 95
Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys
100 105
<210> 1663
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1663
Val Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Asn Lys Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Arg
85 90 95
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1664
<211> 111
<212> PRT
<213> Homo sapiens
<400> 1664
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln
1 5 10 15
Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly
20 25 30
Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu
35 40 45
Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Ser Cys Gln Ser Tyr Asp Ser Ser
85 90 95
Leu Ser Gly Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 1665
<211> 111
<212> PRT
<213> Homo sapiens
<400> 1665
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr
20 25 30
Asn Leu Val Ser Trp Tyr Gln Gln His Ala Gly Lys Ala Pro Lys Leu
35 40 45
Met Ile Tyr Glu Val Ile Lys Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Val Ser
85 90 95
Thr Thr Tyr Val Ile Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1666
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1666
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Asn Pro Ser
85 90 95
Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1667
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1667
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ala Ser Ser
20 25 30
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
35 40 45
Ile Tyr Gly Ala Ser Gly Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65 70 75 80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro
85 90 95
Pro Arg Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 1668
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1668
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Thr Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Leu Leu
85 90 95
Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1669
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1669
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly
1 5 10 15
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser
20 25 30
Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Gln Phe Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ile Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala
85 90 95
Leu Gln Thr Pro Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys
100 105 110
<210> 1670
<211> 109
<212> PRT
<213> Homo sapiens
<400> 1670
Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys
1 5 10 15
Thr Ala Ser Ile Thr Cys Glu Gly Asn Asn Ile Gly Ser Lys Ser Val
20 25 30
His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr
35 40 45
Tyr Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp Arg
85 90 95
Leu Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105
<210> 1671
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1671
Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Asn Pro Ser
85 90 95
Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1672
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1672
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr
20 25 30
Asn Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Met Ile Tyr Glu Gly Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Ile Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Ser
85 90 95
Ser Thr Trp Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1673
<211> 111
<212> PRT
<213> Homo sapiens
<400> 1673
Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys
1 5 10 15
Thr Val Thr Ile Ser Cys Thr Gly Ser Ser Gly Ser Ile Ala Ser Asn
20 25 30
Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ala Pro Thr Thr Val
35 40 45
Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly
65 70 75 80
Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser
85 90 95
Thr Ser Arg Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1674
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1674
Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Arg
1 5 10 15
Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val
20 25 30
His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr
35 40 45
Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Lys Phe Gly Asn Thr Ala Thr Leu Ile Ile Ser Arg Val Glu Ala Gly
65 70 75 80
Asp Glu Ala Asp Tyr Ser Cys Gln Val Trp Asp Ser Gly Ser Asp His
85 90 95
Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu
100 105
<210> 1675
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1675
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Ile
35 40 45
Tyr Ala Ala Ser Thr Met Gln Ser Gly Val Pro Ser Arg Phe Arg Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Leu
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Gln
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1676
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1676
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln
1 5 10 15
Arg Val Thr Ile Ser Cys Ser Gly Gly Ser Ser Asn Ile Gly Asn Asn
20 25 30
Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Tyr Asp Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser
50 55 60
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Trp Asp Asp Ser Leu
85 90 95
Ile Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1677
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1677
Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Thr Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Ser Tyr Pro Gly
85 90 95
Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1678
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1678
Asn Leu Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys
1 5 10 15
Thr Val Thr Ile Ser Cys Thr Gly Ser Ser Gly Ser Ile Ala Ser Asn
20 25 30
Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ala Pro Thr Thr Val
35 40 45
Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly
65 70 75 80
Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser
85 90 95
Asn Asn Gln Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1679
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1679
Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys
1 5 10 15
Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Ile Ala Ser Ser
20 25 30
Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ala Pro Thr Thr Val
35 40 45
Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly
65 70 75 80
Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser
85 90 95
Ser Asp Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1680
<211> 109
<212> PRT
<213> Homo sapiens
<400> 1680
Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys
1 5 10 15
Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Asn Val
20 25 30
His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Lys Val Val Tyr
35 40 45
His Asp Gly Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Asn Arg Val Glu Ala Gly
65 70 75 80
Asp Glu Ala Asp Tyr Ser Cys Gln Val Trp Asp Ser Ser Ser Asp His
85 90 95
His Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1681
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1681
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
1 5 10 15
Thr Ala Arg Ile Thr Cys Phe Gly Asp Ala Leu Pro Lys Gln Tyr Ala
20 25 30
Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Gly Pro Val Leu Val Ile Tyr
35 40 45
Lys Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Thr Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Val Gln Ala Glu
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Ala Asp Ser Ser Gly Thr Tyr
85 90 95
Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1682
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1682
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
1 5 10 15
Glu Arg Val Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn
20 25 30
Leu Ala Trp Cys Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Asn Trp Pro Leu
85 90 95
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1683
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1683
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
1 5 10 15
Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Lys Gln Tyr Ala
20 25 30
Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr
35 40 45
Lys Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Ser Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Val Gln Ala Glu
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Ala Asp Ser Ser Ala Ala Tyr
85 90 95
Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1684
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1684
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
1 5 10 15
Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Lys Lys Tyr Thr
20 25 30
Tyr Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Val Val Val Ile Tyr
35 40 45
Glu Asp Ser Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Ser Ser Gly Thr Met Ala Thr Leu Thr Ile Ser Gly Ala Gln Val Glu
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Tyr Ser Thr Asp Ser Ser Gly Lys Gly
85 90 95
Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1685
<211> 109
<212> PRT
<213> Homo sapiens
<400> 1685
Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys
1 5 10 15
Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val
20 25 30
His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr
35 40 45
Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp Pro
85 90 95
Phe Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105
<210> 1686
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1686
Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys
1 5 10 15
Thr Val Thr Ile Ser Cys Thr Gly Ser Ser Gly Ser Ile Ala Ser Asn
20 25 30
Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ala Pro Thr Thr Val
35 40 45
Ile Ser Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly
65 70 75 80
Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly
85 90 95
Ile Asn Arg Ala Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1687
<211> 113
<212> PRT
<213> Homo sapiens
<400> 1687
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu His Ser
20 25 30
Ser Asn Asn Lys Asp Ser Leu Val Trp Tyr Gln Gln Lys Pro Gly Gln
35 40 45
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ser Arg Glu Ser Gly Val
50 55 60
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln
85 90 95
Tyr Tyr Ser Thr Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile
100 105 110
Lys
<210> 1688
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1688
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Ser Tyr
85 90 95
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1689
<211> 109
<212> PRT
<213> Homo sapiens
<400> 1689
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Asn Asn
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Val Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asp Asp Trp Pro Pro
85 90 95
Glu Val Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1690
<211> 111
<212> PRT
<213> Homo sapiens
<400> 1690
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln
1 5 10 15
Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ser Gly
20 25 30
Ser Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu
35 40 45
Leu Ile Tyr Gly Asn Thr Asn Arg Pro Ser Gly Val Pro Asp Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Val Ala Trp Asp Asp Ser
85 90 95
Arg Asn Gly Leu Val Phe Gly Gly Gly Ala Lys Leu Thr Val Leu
100 105 110
<210> 1691
<211> 111
<212> PRT
<213> Homo sapiens
<400> 1691
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Val Pro Gly Gln
1 5 10 15
Arg Val Thr Val Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly
20 25 30
Phe Asp Val Tyr Trp Tyr Gln Gln Phe Leu Gly Thr Ala Pro Lys Leu
35 40 45
Leu Ile Tyr Gly Asn Asn Asn Arg Pro Ser Gly Val Pro Asp Arg Phe
50 55 60
Ser Ala Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Phe Asp Ile Gly
85 90 95
Arg Gly Gly Trp Ile Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1692
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1692
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Pro Ser Gln Ser Ile Thr Thr Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Ala Val Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro
85 90 95
Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys
100 105
<210> 1693
<211> 111
<212> PRT
<213> Homo sapiens
<400> 1693
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln
1 5 10 15
Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly
20 25 30
Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Glu Thr Ala Pro Lys Leu
35 40 45
Leu Ile Tyr Ala Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser
85 90 95
Leu Ser Gly Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1694
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1694
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr
20 25 30
Asn Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Lys Ile Tyr Glu Gly Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Ser
85 90 95
Val Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1695
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1695
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Ala Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Arg Tyr Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Ala Tyr Tyr Cys Gln Gln Ser Phe Ser Thr Pro Arg
85 90 95
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1696
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1696
Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys
1 5 10 15
Thr Ala Asn Ile Thr Cys Gly Gly Asn Asn Ile Gly Arg Lys Ser Val
20 25 30
His Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Val Leu Val Val Tyr
35 40 45
Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp His
85 90 95
Pro Glu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1697
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1697
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly
1 5 10 15
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser
20 25 30
Asn Gly Tyr Asn Phe Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Gln Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala
85 90 95
Leu Gln Thr Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105 110
<210> 1698
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1698
Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln
1 5 10 15
Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Arg Tyr Tyr Ala
20 25 30
Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr
35 40 45
Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser
50 55 60
Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn Pro
85 90 95
Arg Trp Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1699
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1699
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser
20 25 30
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
35 40 45
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65 70 75 80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro
85 90 95
Pro Arg Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 1700
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1700
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
1 5 10 15
Thr Ala Arg Ile Thr Cys Ser Thr Asp Ala Leu Pro Asn Glu Tyr Ile
20 25 30
Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr
35 40 45
Lys Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Ser Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Val Gln Ala Glu
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Val Asp Ser Ser Gly Thr Tyr
85 90 95
Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1701
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1701
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Ala Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Asp Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Leu
85 90 95
Ala Phe Gly Pro Gly Thr Lys Val Asp Val Lys
100 105
<210> 1702
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1702
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly
1 5 10 15
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser
20 25 30
Asp Gly Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser
35 40 45
Pro Arg Arg Leu Ile Tyr Lys Val Ser Ser Arg Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly
85 90 95
Thr His Trp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 1703
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1703
Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr
20 25 30
Thr Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Met Ile Tyr Asp Val Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Ile Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Arg
85 90 95
Tyr Thr Trp Val Phe Gly Gly Gly Thr Thr Leu Thr Val Leu
100 105 110
<210> 1704
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1704
Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Thr Ala Pro Asn Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Leu Leu Asn Ser His Pro Leu
85 90 95
Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys
100 105
<210> 1705
<211> 106
<212> PRT
<213> Homo sapiens
<400> 1705
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
1 5 10 15
Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Lys Gln Tyr Ala
20 25 30
Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr
35 40 45
Arg Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Thr Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Val Gln Ala Glu
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Ala Asp Ser Thr Gly Trp Val
85 90 95
Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1706
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1706
Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly
1 5 10 15
Gln Pro Ala Ser Phe Ser Cys Lys Ser Ser Gln Ser Leu Leu His Ser
20 25 30
Asp Gly Lys Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Gln Leu Leu Ile Tyr Ala Val Ser Asn Arg Phe Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ser
85 90 95
Ile Gln Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 1707
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1707
Asp Ile Val Val Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly
1 5 10 15
Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Glu Thr Leu Leu His Ser
20 25 30
Asp Gly Lys Thr Tyr Leu Ser Trp Tyr Leu Gln Lys Pro Gly Gln Pro
35 40 45
Pro Gln Leu Leu Ile Tyr Glu Val Ser Asn Arg Phe Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Gly Arg Val Glu Ala Glu Asp Val Gly Leu Tyr Tyr Cys Met Gln Ser
85 90 95
Ile Gln Leu Ala Phe Gly Gln Gly Thr Arg Leu Glu Ile Glu
100 105 110
<210> 1708
<211> 109
<212> PRT
<213> Homo sapiens
<400> 1708
Glu Thr Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser
20 25 30
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
35 40 45
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65 70 75 80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Tyr Gly Ser Ser Arg
85 90 95
Gly Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1709
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1709
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
1 5 10 15
Glu Arg Val Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn
20 25 30
Leu Ala Trp Cys Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Asn Trp Pro Leu
85 90 95
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1710
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1710
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Ile Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp
20 25 30
Leu Ala Trp Tyr Gln Gln Ile Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr
85 90 95
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1711
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1711
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Glu Ile Pro Pro
85 90 95
Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1712
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1712
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ala Asn Leu Pro Phe
85 90 95
Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys
100 105
<210> 1713
<211> 109
<212> PRT
<213> Homo sapiens
<400> 1713
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser
20 25 30
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
35 40 45
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65 70 75 80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Tyr Gly Ser Ser Arg
85 90 95
Gly Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1714
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1714
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
1 5 10 15
Thr Ala Arg Ile Thr Cys Ser Thr Asp Ala Leu Pro Asn Glu Tyr Ile
20 25 30
Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr
35 40 45
Lys Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Ser Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Val Gln Ala Glu
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Val Asp Ser Ser Gly Thr Tyr
85 90 95
Pro His Val Ile Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1715
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1715
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln
1 5 10 15
Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly
20 25 30
Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu
35 40 45
Leu Ile Tyr Gly Asn Thr Asn Arg Pro Ser Gly Val Pro Asp Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Ala Ser Ser
85 90 95
Leu Ser Ala His Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1716
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1716
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser
20 25 30
Ser Asn Asn Glu Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
35 40 45
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln
85 90 95
Tyr Tyr Ser Ser Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105 110
<210> 1717
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1717
Glu Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser
20 25 30
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
35 40 45
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65 70 75 80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro
85 90 95
Pro Pro Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys
100 105 110
<210> 1718
<211> 111
<212> PRT
<213> Homo sapiens
<400> 1718
Asn Phe Met Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Ala Ser Ser Asp Val Gly Gly Tyr
20 25 30
Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser
85 90 95
Ser Thr Pro Val Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu
100 105 110
<210> 1719
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1719
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Val Ala Thr Tyr Tyr Cys Gln Lys Tyr Asn Ser Ala Pro Pro
85 90 95
Ala Phe Gly Gln Gly Thr Lys Val Asp Ile Lys
100 105
<210> 1720
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1720
Gln Ser Ala Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
1 5 10 15
Thr Ala Ser Ile Pro Cys Ser Gly Asp Lys Leu Gly Asp Ile Tyr Ala
20 25 30
Cys Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr
35 40 45
Gln Asp Thr Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Gly Ser Thr Thr Ala Lys
85 90 95
Val Phe Gly Gly Gly Thr Lys Leu Thr Val Pro
100 105
<210> 1721
<211> 109
<212> PRT
<213> Homo sapiens
<400> 1721
Asp Ile Gln Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro
85 90 95
Arg Val Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1722
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1722
Gln Ser Val Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr
20 25 30
Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser
85 90 95
Ser Thr Arg His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1723
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1723
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Arg
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Thr Ser Ser
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Tyr
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1724
<211> 111
<212> PRT
<213> Homo sapiens
<400> 1724
Asn Phe Met Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Ser Ser Ser Asp Ile Ala Pro Tyr
20 25 30
Thr Phe Val Ser Trp Tyr Gln Gln His Ser Gly Thr Ala Pro Lys Leu
35 40 45
Ile Ile Tyr Asp Val Arg Asn Arg Pro Ser Gly Ile Ser Asp Arg Phe
50 55 60
Ser Gly Ser Arg Ser Gly Asn Thr Ala Ser Leu Ser Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ala Tyr Thr Thr Thr
85 90 95
Ser Thr Ser Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1725
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1725
Gln Ser Ala Leu Thr Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Ile Gly Thr Tyr
20 25 30
Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Met Ile Tyr Glu Val Thr Lys Arg Pro Ser Gly Val Pro Asp Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly Leu
65 70 75 80
Gln Ala Asp Asp Glu Gly Asp Tyr Tyr Cys Ser Ser Tyr Val Gly Asn
85 90 95
Asn Asn Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1726
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1726
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Pro Pro Leu
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1727
<211> 109
<212> PRT
<213> Homo sapiens
<400> 1727
Gln Ser Ala Leu Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly
1 5 10 15
Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly
20 25 30
His Tyr Pro Tyr Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Arg Thr
35 40 45
Leu Ile Tyr Asp Thr Ser Asn Lys Arg Ser Trp Thr Pro Ala Arg Phe
50 55 60
Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Ala
65 70 75 80
Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Leu Leu Ser Tyr Ser Gly
85 90 95
Val Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1728
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1728
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Pro
85 90 95
Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1729
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1729
Asn Phe Met Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys
1 5 10 15
Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val
20 25 30
His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr
35 40 45
Tyr Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp His
85 90 95
Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1730
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1730
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Tyr Arg Ala Ser Gln Ser Val Ser Ser Asn
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Pro
85 90 95
Gly Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1731
<211> 106
<212> PRT
<213> Homo sapiens
<400> 1731
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
1 5 10 15
Thr Ala Ser Ile Thr Cys Ser Gly Asp Lys Leu Gly Asp Lys Tyr Ala
20 25 30
Cys Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Thr Tyr
35 40 45
Gln Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Ser Thr Ala Val
85 90 95
Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1732
<211> 109
<212> PRT
<213> Homo sapiens
<400> 1732
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
1 5 10 15
Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Lys Gln Tyr Ala
20 25 30
Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr
35 40 45
Lys Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Ser Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Val Gln Ala Glu
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Ala Asp Ser Ser Gly Thr Tyr
85 90 95
Ser Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1733
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1733
Asp Ile Gln Leu Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Ser Ile
85 90 95
Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys
100 105
<210> 1734
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1734
Asp Ile Val Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu His Ser Tyr Pro Leu
85 90 95
Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys
100 105
<210> 1735
<211> 109
<212> PRT
<213> Homo sapiens
<400> 1735
Asp Val Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asn Val Ser Ser Ser
20 25 30
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
35 40 45
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65 70 75 80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro
85 90 95
Leu Phe Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1736
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1736
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro
85 90 95
Val Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1737
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1737
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asn Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Leu
35 40 45
Tyr Ala Ala Ser Asp Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr His Met
85 90 95
Ser Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys
100 105
<210> 1738
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1738
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Gln
85 90 95
Val Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys
100 105
<210> 1739
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1739
Glu Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser
20 25 30
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
35 40 45
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65 70 75 80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Leu Tyr
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys
100 105
<210> 1740
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1740
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Leu
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1741
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1741
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser
20 25 30
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
35 40 45
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Trp Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65 70 75 80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro
85 90 95
Gly Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys
100 105
<210> 1742
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1742
Asp Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser
20 25 30
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
35 40 45
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65 70 75 80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Leu
85 90 95
Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1743
<211> 109
<212> PRT
<213> Homo sapiens
<400> 1743
Asp Ile Gln Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser
20 25 30
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
35 40 45
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65 70 75 80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro
85 90 95
Arg Leu Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys
100 105
<210> 1744
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1744
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Pro
85 90 95
Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1745
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1745
Glu Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser
20 25 30
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
35 40 45
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65 70 75 80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro
85 90 95
Gly Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1746
<211> 109
<212> PRT
<213> Homo sapiens
<400> 1746
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Glu Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro
85 90 95
Met Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1747
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1747
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly
1 5 10 15
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser
20 25 30
Asp Gly Asn Thr Phe Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser
35 40 45
Pro Arg Arg Leu Ile Tyr Gln Val Ser Asn Arg Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly
85 90 95
Thr His Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 1748
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1748
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp
20 25 30
Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser Tyr Pro Pro
85 90 95
Leu Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1749
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1749
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro
85 90 95
Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1750
<211> 109
<212> PRT
<213> Homo sapiens
<400> 1750
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro
85 90 95
Ser Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys
100 105
<210> 1751
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1751
Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp
20 25 30
Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser Tyr Leu Trp
85 90 95
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1752
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1752
Ala Ile Arg Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Ile
85 90 95
Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys
100 105
<210> 1753
<211> 109
<212> PRT
<213> Homo sapiens
<400> 1753
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser
20 25 30
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
35 40 45
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65 70 75 80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro
85 90 95
Gly Val Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1754
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1754
Ala Ile Arg Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Gln
85 90 95
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1755
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1755
Gln Pro Val Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr
20 25 30
Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Ser Gly Ser Arg Ser Gly Asp Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser
85 90 95
Ser Thr Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1756
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1756
Gln Leu Val Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
1 5 10 15
Thr Ala Ser Ile Thr Cys Ser Gly Asp Lys Leu Gly Asp Lys Tyr Ala
20 25 30
Cys Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr
35 40 45
Gln Asp Ser Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Ser Thr Ala Val
85 90 95
Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1757
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1757
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn
20 25 30
Leu Ala Trp Tyr Gln His Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Tyr Trp Pro Leu
85 90 95
Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys
100 105
<210> 1758
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1758
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Arg
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1759
<211> 106
<212> PRT
<213> Homo sapiens
<400> 1759
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln
1 5 10 15
Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val
20 25 30
His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr
35 40 45
Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Ala Ser Ser Ser Val Val
85 90 95
Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1760
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1760
Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly
1 5 10 15
Gln Pro Ala Ser Ile Ser Cys Lys Ser Gly Gln Ser Leu Leu His Ser
20 25 30
Asp Gly Lys Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Pro
35 40 45
Pro Gln Leu Leu Ile Tyr Glu Val Ser Asn Arg Phe Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ser
85 90 95
Ile Gln Leu Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105 110
<210> 1761
<211> 109
<212> PRT
<213> Homo sapiens
<400> 1761
Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Phe
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro
85 90 95
Arg Leu Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys
100 105
<210> 1762
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1762
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr
20 25 30
Asn Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Met Ile Tyr Asp Ser Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Ser
85 90 95
Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1763
<211> 113
<212> PRT
<213> Homo sapiens
<400> 1763
Gln Thr Val Val Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr
20 25 30
Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser
85 90 95
Ser Thr Leu Gly Leu Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val
100 105 110
Leu
<210> 1764
<211> 111
<212> PRT
<213> Homo sapiens
<400> 1764
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln
1 5 10 15
Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly
20 25 30
Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Val
35 40 45
Leu Ile Tyr Asp Asn Asn Asn Arg Pro Ser Gly Val Pro Asp Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser
85 90 95
Leu Ser Gly Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1765
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1765
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp
20 25 30
Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser Tyr Pro Leu
85 90 95
Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys
100 105
<210> 1766
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1766
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr
20 25 30
Asn Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Met Ile Tyr Glu Val Thr Lys Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Ser
85 90 95
Ser Thr Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1767
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1767
Gln Ser Val Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr
20 25 30
Asn Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Met Ile Tyr Glu Ala Ser Lys Arg Pro Ser Gly Ile Ser Asn Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Ser
85 90 95
Ser Thr Trp Val Phe Gly Gly Gly Thr Lys Pro Thr Val Leu
100 105 110
<210> 1768
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1768
Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Cys Tyr Asn Trp Pro Pro
85 90 95
Trp Thr Phe Gly Gln Gly Thr Arg Val Glu Phe Lys
100 105
<210> 1769
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1769
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp
20 25 30
Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser Tyr Pro Leu
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1770
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1770
Ala Ile Arg Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Thr Thr Phe Ile
85 90 95
Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1771
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1771
Asp Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser
20 25 30
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
35 40 45
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65 70 75 80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro
85 90 95
Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1772
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1772
Ala Ile Arg Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Leu Ser
85 90 95
Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1773
<211> 114
<212> PRT
<213> Homo sapiens
<400> 1773
Glu Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser
20 25 30
Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
35 40 45
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr His Phe Thr Leu Thr
65 70 75 80
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln
85 90 95
Tyr Tyr Ser Thr Pro Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Asp
100 105 110
Ile Lys
<210> 1774
<211> 106
<212> PRT
<213> Homo sapiens
<400> 1774
Glu Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Met Ser Ser Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Leu Thr
85 90 95
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1775
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1775
Gln Thr Val Val Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
1 5 10 15
Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Lys Gln Tyr Ala
20 25 30
Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr
35 40 45
Lys Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Ser Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Val Gln Ala Glu
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Ala Asp Ser Ser Gly Thr Tyr
85 90 95
Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1776
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1776
Gln Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln
1 5 10 15
Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val
20 25 30
His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr
35 40 45
Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp His
85 90 95
Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105
<210> 1777
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1777
Asn Phe Met Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn
20 25 30
Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu
85 90 95
Asn Gly Pro His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1778
<211> 113
<212> PRT
<213> Homo sapiens
<400> 1778
Asp Val Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser
20 25 30
Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
35 40 45
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln
85 90 95
Tyr Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Asp Ile
100 105 110
Lys
<210> 1779
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1779
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser
20 25 30
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
35 40 45
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65 70 75 80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro
85 90 95
Phe Thr Phe Gly Pro Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1780
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1780
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu
85 90 95
Thr Phe Gly Pro Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1781
<211> 106
<212> PRT
<213> Homo sapiens
<400> 1781
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Met Ser Ser Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Leu Thr
85 90 95
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1782
<211> 113
<212> PRT
<213> Homo sapiens
<400> 1782
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser
20 25 30
Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
35 40 45
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln
85 90 95
Tyr Tyr Ser Thr Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile
100 105 110
Lys
<210> 1783
<211> 113
<212> PRT
<213> Homo sapiens
<400> 1783
Asp Ile Gln Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser
20 25 30
Ser Ile Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
35 40 45
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln
85 90 95
Tyr Tyr Ser Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile
100 105 110
Lys
<210> 1784
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1784
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn
20 25 30
Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu
85 90 95
Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1785
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1785
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ile
20 25 30
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
35 40 45
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65 70 75 80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Ala Gly Ser Pro
85 90 95
Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1786
<211> 109
<212> PRT
<213> Homo sapiens
<400> 1786
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro
85 90 95
Ile Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys
100 105
<210> 1787
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1787
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly
1 5 10 15
Gln Pro Ala Thr Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser
20 25 30
Asp Gly Asn Thr Tyr Val Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser
35 40 45
Pro Arg Arg Leu Ile Tyr Gln Val Ser Ile Arg Ala Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ala Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly
85 90 95
Thr His Trp Pro Val Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105 110
<210> 1788
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1788
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Asp Asn Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Ile Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Leu Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Asn Pro Leu
85 90 95
Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Arg
100 105
<210> 1789
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1789
Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr
20 25 30
Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Met Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Ser
85 90 95
Tyr Thr Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1790
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1790
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser
20 25 30
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
35 40 45
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65 70 75 80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Arg
85 90 95
Gly Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1791
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1791
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr
20 25 30
Asn Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Met Ile Tyr Glu Gly Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Ser
85 90 95
Ser Thr Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 1792
<211> 111
<212> PRT
<213> Homo sapiens
<400> 1792
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln
1 5 10 15
Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn
20 25 30
Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln
65 70 75 80
Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu
85 90 95
Ser Ala Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1793
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1793
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser
20 25 30
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
35 40 45
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65 70 75 80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro
85 90 95
Pro Lys Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 1794
<211> 109
<212> PRT
<213> Homo sapiens
<400> 1794
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Pro
85 90 95
Ser Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1795
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1795
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Leu
85 90 95
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1796
<211> 111
<212> PRT
<213> Homo sapiens
<400> 1796
Gln Leu Val Leu Thr Gln Ser Pro Ser Ala Ser Ala Ser Leu Gly Ala
1 5 10 15
Ser Val Lys Leu Thr Cys Thr Leu Ser Ser Gly His Ser Ser Tyr Ala
20 25 30
Ile Ala Trp His Gln Gln Gln Pro Glu Lys Gly Pro Arg Tyr Leu Met
35 40 45
Lys Leu Asn Ser Asp Gly Ser His Ser Lys Gly Asp Gly Ile Pro Asp
50 55 60
Arg Phe Ser Gly Ser Ser Ser Gly Ala Glu Arg Tyr Leu Thr Ile Ser
65 70 75 80
Ser Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Thr Trp Gly
85 90 95
Thr Gly Ile Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1797
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1797
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
1 5 10 15
Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Lys Gln Tyr Ala
20 25 30
Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr
35 40 45
Lys Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Ser Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Val Gln Ala Glu
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Ala Asp Ser Ser Gly Thr Tyr
85 90 95
Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1798
<211> 111
<212> PRT
<213> Homo sapiens
<400> 1798
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln
1 5 10 15
Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn
20 25 30
Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln
65 70 75 80
Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu
85 90 95
Ser Ala Ser Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 1799
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1799
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Tyr
85 90 95
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1800
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1800
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp
20 25 30
Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser Tyr Pro Phe
85 90 95
Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys
100 105
<210> 1801
<211> 111
<212> PRT
<213> Homo sapiens
<400> 1801
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr
20 25 30
Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser
85 90 95
Ser Thr Pro Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 1802
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1802
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Asp Asn Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Ile Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Leu Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Asn Pro Leu
85 90 95
Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Arg
100 105
<210> 1803
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1803
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser
20 25 30
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
35 40 45
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65 70 75 80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro
85 90 95
Gln Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1804
<211> 111
<212> PRT
<213> Homo sapiens
<400> 1804
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln
1 5 10 15
Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn
20 25 30
Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln
65 70 75 80
Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu
85 90 95
Ser Ala Ser Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 1805
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1805
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln
1 5 10 15
Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn
20 25 30
Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln
65 70 75 80
Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu
85 90 95
Ser Ala Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1806
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1806
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln
1 5 10 15
Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly
20 25 30
Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu
35 40 45
Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser
85 90 95
Leu Ser Gly Pro Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1807
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1807
Ser Tyr Glu Leu Thr Gln Pro His Ser Val Ser Val Ala Thr Ala Gln
1 5 10 15
Met Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ala Val
20 25 30
His Trp Tyr Gln Gln Lys Pro Gly Gln Asp Pro Val Leu Val Ile Tyr
35 40 45
Ser Asp Ser Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Asn Pro Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Ile Glu Ala Gly
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp His
85 90 95
Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1808
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1808
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn
20 25 30
Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu
85 90 95
Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1809
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1809
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
1 5 10 15
Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Lys Gln Tyr Ala
20 25 30
Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr
35 40 45
Lys Asp Thr Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Ser Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Val Gln Ala Glu
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Ala Asp Ser Ser Gly Thr Tyr
85 90 95
Met Ile Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105
<210> 1810
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1810
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Arg
85 90 95
Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Arg
100 105
<210> 1811
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1811
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro
85 90 95
Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys
100 105
<210> 1812
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1812
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly
1 5 10 15
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser
20 25 30
Asp Gly Asn Thr Tyr Val Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser
35 40 45
Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ala Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly
85 90 95
Thr His Trp Pro Val Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105 110
<210> 1813
<211> 105
<212> PRT
<213> Homo sapiens
<400> 1813
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Thr Phe
85 90 95
Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1814
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1814
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp
20 25 30
Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser Tyr Pro Leu
85 90 95
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1815
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1815
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Leu
85 90 95
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1816
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1816
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Phe Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Tyr Ile Thr Ala Phe
85 90 95
Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys
100 105
<210> 1817
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1817
Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys
1 5 10 15
Thr Val Thr Ile Ser Cys Thr Gly Ser Ser Gly Ser Ile Ala Ser Asn
20 25 30
Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ala Pro Thr Thr Val
35 40 45
Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly
65 70 75 80
Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser
85 90 95
Ser Asn Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1818
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1818
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
1 5 10 15
Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Lys Gln Tyr Ala
20 25 30
Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Val Val Ile Tyr
35 40 45
Lys Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Ser Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Val Gln Ala Glu
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Ala Asp Ser Ser Gly Thr Tyr
85 90 95
Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1819
<211> 111
<212> PRT
<213> Homo sapiens
<400> 1819
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln
1 5 10 15
Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly
20 25 30
Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu
35 40 45
Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser
85 90 95
Leu Thr Leu Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 1820
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1820
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly
1 5 10 15
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser
20 25 30
Asp Gly Asn Thr Tyr Val Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser
35 40 45
Pro Arg Arg Leu Ile Tyr Gln Val Ser Ile Arg Ala Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ala Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly
85 90 95
Thr His Trp Pro Val Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105 110
<210> 1821
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1821
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp
20 25 30
Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser Tyr Pro Leu
85 90 95
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1822
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1822
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly
1 5 10 15
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser
20 25 30
Asp Gly Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser
35 40 45
Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro
50 55 60
Asp Lys Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly
85 90 95
Thr His Trp Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105 110
<210> 1823
<211> 113
<212> PRT
<213> Homo sapiens
<400> 1823
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Asn Val Leu Tyr Ser
20 25 30
Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
35 40 45
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln
85 90 95
Tyr Tyr Ile Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile
100 105 110
Lys
<210> 1824
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1824
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
1 5 10 15
Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Lys Lys Tyr Ala
20 25 30
Tyr Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Val Leu Val Ile Tyr
35 40 45
Glu Asp Ser Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Ser Ser Gly Thr Met Ala Thr Leu Thr Ile Ser Gly Ala Gln Val Glu
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Tyr Ser Thr Asp Ser Ser Gly Asn Leu
85 90 95
Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105
<210> 1825
<211> 105
<212> PRT
<213> Homo sapiens
<400> 1825
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Thr Phe
85 90 95
Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1826
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1826
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser
20 25 30
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
35 40 45
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65 70 75 80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro
85 90 95
Gly Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys
100 105
<210> 1827
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1827
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr
20 25 30
Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ile
85 90 95
Ser Thr Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1828
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1828
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Leu Ala
85 90 95
Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1829
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1829
Gln Ser Ala Leu Thr Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr
20 25 30
Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Met Ile Tyr Glu Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ala Gly Ser
85 90 95
Asn Asn Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1830
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1830
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser
20 25 30
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
35 40 45
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65 70 75 80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro
85 90 95
Gly Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1831
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1831
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Val Ser Asn Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Gln Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Asp Ala Phe Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Leu
85 90 95
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1832
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1832
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Val Ser Asn Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Gln Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Asp Ala Phe Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Leu
85 90 95
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1833
<211> 113
<212> PRT
<213> Homo sapiens
<400> 1833
Asp Ile Gln Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly
1 5 10 15
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Asp Ser
20 25 30
Asp Asp Gly Asn Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln
35 40 45
Ser Pro Gln Leu Leu Ile Tyr Thr Leu Ser Tyr Arg Ala Ser Gly Val
50 55 60
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys
65 70 75 80
Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln
85 90 95
Arg Ile Glu Phe Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile
100 105 110
Lys
<210> 1834
<211> 109
<212> PRT
<213> Homo sapiens
<400> 1834
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Leu Ser Leu Ser Ser Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro
85 90 95
Thr Trp Thr Phe Gly Gln Gly Thr Lys Ala Glu Ile Lys
100 105
<210> 1835
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1835
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser
20 25 30
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
35 40 45
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Val Glu
65 70 75 80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro
85 90 95
Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1836
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1836
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Val Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Asp Asn Trp
20 25 30
Leu Ala Trp Tyr Gln Glu Lys Pro Gly Lys Ala Pro Lys Val Leu Ile
35 40 45
Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Arg Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Gly Asp Phe Ala Thr Tyr Tyr Cys Gln His Tyr His Ser Phe Pro Leu
85 90 95
Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys
100 105
<210> 1837
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1837
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Gly Val Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Arg
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1838
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1838
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Ser Gly Ala Ser Ser Arg Ala Ala Gly Ile Pro Asp Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Arg Leu Glu Pro
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Arg
85 90 95
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1839
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1839
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser
20 25 30
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
35 40 45
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65 70 75 80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Arg Ser Pro
85 90 95
Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile
100 105
<210> 1840
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1840
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Ala Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr
20 25 30
Leu Asn Trp Tyr Gln Glu Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Asn Pro Leu
85 90 95
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1841
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1841
Gln Pro Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln
1 5 10 15
Arg Ile Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly
20 25 30
Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu
35 40 45
Leu Ile Tyr Gly Ser Ser Ser Arg Pro Ser Gly Val Pro Asp Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser
85 90 95
Leu Ser Val Leu Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 1842
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1842
Asp Ile Val Leu Thr Gln Thr Pro Ala Thr Leu Ser Val Ser Pro Gly
1 5 10 15
Glu Gly Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Ser Asn
20 25 30
Leu Ala Trp Phe Gln Gln Arg Pro Gly Gln Val Pro Arg Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Thr Arg Ala Thr Gly Val Pro Ala Arg Phe Thr Gly
50 55 60
Ser Gly Ser Gly Thr Tyr Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Ser Trp Pro Pro
85 90 95
Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1843
<211> 106
<212> PRT
<213> Homo sapiens
<400> 1843
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
1 5 10 15
Glu Thr Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Arg Phe
20 25 30
Met Gly Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Phe Asp Ala Ser Asn Arg Val Thr Gly Val Pro Asp Arg Phe Arg Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Ile Leu Thr Ile Asn Ser Leu Glu Pro
65 70 75 80
Glu Asp Ser Ala Ser Tyr Tyr Cys Gln Arg Arg Gly Asp Gly Tyr Asn
85 90 95
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1844
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1844
Glu Thr Thr Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly
1 5 10 15
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Gly Leu Val His Ser
20 25 30
Asp Gly Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser
35 40 45
Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Ile Gly Val Tyr Tyr Cys Met Gln Gly
85 90 95
Thr Glu Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105 110
<210> 1845
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1845
Asp Ile Arg Val Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly
1 5 10 15
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Arg Ile Val His Thr
20 25 30
Asp Gly Asn Thr Tyr Leu Asn Trp Phe Leu Gln Arg Pro Gly Gln Ser
35 40 45
Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Met Gln Gly
85 90 95
Thr Glu Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys
100 105 110
<210> 1846
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1846
Glu Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Gly His Thr Ile Ser Thr Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Ile Leu Ile
35 40 45
Ser Gly Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Gly Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Tyr
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys
100 105
<210> 1847
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1847
Gln Pro Val Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ser Thr Leu Ser Cys Ser Gly Thr Ser Ser Asp Val Gly Ser Tyr
20 25 30
Asp Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Met Ile Tyr Glu Gly Thr Lys Arg Pro Ser Gly Val Ser Asp Arg Phe
50 55 60
Ser Gly Ser Thr Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asn Tyr Tyr Cys Cys Ser Tyr Ala Gly Ser
85 90 95
Gly Thr Trp Ile Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1848
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1848
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Asp Arg Val Thr Leu Phe Cys Arg Ala Ser Gln Asn Ile Ala Asn Asn
20 25 30
His Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Val Leu
35 40 45
Ile Tyr Gly Ala Ser Thr Thr Ala Thr Asp Ile Pro Asp Arg Phe Ser
50 55 60
Gly Arg Val Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Asp
65 70 75 80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Tyr Gly Ser Ser Pro
85 90 95
Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1849
<211> 106
<212> PRT
<213> Homo sapiens
<400> 1849
Glu Thr Thr Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
1 5 10 15
Glu Thr Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Arg Phe
20 25 30
Met Gly Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Phe Asp Ala Ser Asn Arg Val Thr Gly Val Pro Asp Arg Phe Arg Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Ile Leu Thr Ile Asn Ser Leu Glu Pro
65 70 75 80
Glu Asp Ser Ala Ser Tyr Tyr Cys Gln Arg Arg Gly Asp Gly Tyr Asn
85 90 95
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1850
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1850
Asp Ile Arg Met Thr Gln Ser Pro Leu Ser Leu Pro Val Asp Leu Gly
1 5 10 15
Gln Ser Ala Ser Ile Ser Cys Arg Ser Ser Gln Arg Val Val His Thr
20 25 30
Asn Gly Asn Thr Tyr Leu His Trp Phe His Gln Arg Pro Gly Gln Ala
35 40 45
Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Glu Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala
85 90 95
Thr Asp Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 1851
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1851
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Ser Val Thr Leu Gly
1 5 10 15
Gln Ala Ala Ser Ile Ser Cys Thr Cys Ser Gln Thr Ala Val His Ser
20 25 30
Asp Gly Asn Thr Tyr Leu Asn Trp Phe His Gln Arg Pro Gly Gln Ser
35 40 45
Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Asn Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Met Gln Thr
85 90 95
Thr Asp Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105 110
<210> 1852
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1852
Glu Thr Thr Leu Thr Gln Ser Pro Val Thr Leu Pro Val Thr Leu Gly
1 5 10 15
Gln Pro Ala Ser Ile Ser Cys Thr Ser Ser Arg Trp Leu Val His Thr
20 25 30
Asn Gly Asn Thr Tyr Leu Asn Trp Phe His Gln Arg Pro Gly Gln Ser
35 40 45
Pro Arg Arg Leu Ile Tyr Gln Val Ser Asn Arg Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Gln Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly
85 90 95
Thr Glu Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 1853
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1853
Glu Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Arg Lys Cys
20 25 30
Leu Asn Trp Tyr Gln His Ile Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
His Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Ser Phe Thr Ile Asn Ser Leu His Pro
65 70 75 80
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Phe Glu Asp Leu Pro Ile
85 90 95
Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys
100 105
<210> 1854
<211> 113
<212> PRT
<213> Homo sapiens
<400> 1854
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser
20 25 30
Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
35 40 45
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln
85 90 95
Tyr Tyr Ser Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile
100 105 110
Lys
<210> 1855
<211> 109
<212> PRT
<213> Homo sapiens
<400> 1855
Asp Ile Val Val Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Ala Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Asn Asn
20 25 30
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
35 40 45
Ile Tyr Gly Ala Thr Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65 70 75 80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Thr Ser Pro
85 90 95
Val Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1856
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1856
Gln Pro Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln
1 5 10 15
Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Glu Asn Asn
20 25 30
Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Ala Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln
65 70 75 80
Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Phe Ser Leu
85 90 95
Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1857
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1857
Glu Thr Thr Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly
1 5 10 15
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Gly Leu Val His Thr
20 25 30
Asn Gly Asn Leu Tyr Leu Asn Trp Phe His Gln Arg Pro Gly Gln Ser
35 40 45
Pro Arg Arg Leu Ile Tyr Gln Val Ser Asn Arg Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Met Gln Gly
85 90 95
Thr Glu Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105 110
<210> 1858
<211> 106
<212> PRT
<213> Homo sapiens
<400> 1858
Asp Ile Gln Leu Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Ser Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Lys Ala Ser Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Lys Ser Pro Leu Ser
85 90 95
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1859
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1859
Asp Ile Gln Val Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Lys Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asp Trp His Pro
85 90 95
Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys
100 105
<210> 1860
<211> 106
<212> PRT
<213> Homo sapiens
<400> 1860
Asp Ile Gln Val Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Ser
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Thr Leu Leu Ile
35 40 45
Tyr Thr Ala Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Gly
85 90 95
Phe Gly Pro Gly Thr Lys Val Asp Ile Lys
100 105
<210> 1861
<211> 109
<212> PRT
<213> Homo sapiens
<400> 1861
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ile Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Arg Ala Thr Gly Val Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Asn Leu Glu Pro
65 70 75 80
Glu Asp Phe Ala Ile Tyr Tyr Cys Gln Gln Arg Ala Lys Trp Pro Pro
85 90 95
Arg Val Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys
100 105
<210> 1862
<211> 109
<212> PRT
<213> Homo sapiens
<400> 1862
Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ile Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Asn Leu Glu Pro
65 70 75 80
Glu Asp Phe Ala Ile Tyr Tyr Cys Gln Gln Arg Ala Lys Trp Pro Pro
85 90 95
Arg Val Ile Phe Gly Pro Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1863
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1863
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
1 5 10 15
Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Arg Arg Tyr Ala
20 25 30
Tyr Trp Tyr Gln Gln Arg Ser Gly Gln Ala Pro Val Leu Val Ile Tyr
35 40 45
Glu Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Ala Phe
50 55 60
Ser Ser Gly Thr Met Ala Thr Leu Thr Ile Ser Gly Ala Gln Val Glu
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Tyr Ser Thr Asp Ser Thr Ala Asn Tyr
85 90 95
Lys Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1864
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1864
Glu Thr Thr Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly
1 5 10 15
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Gly Leu Val His Ser
20 25 30
Asn Gly Asn Thr Tyr Val Asn Trp Phe His Gln Arg Pro Gly Gln Ser
35 40 45
Pro Arg Arg Leu Ile Tyr Glu Val Ser Asn Arg Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Ile Gly Val Tyr Tyr Cys Met Gln Gly
85 90 95
Thr Glu Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys
100 105 110
<210> 1865
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1865
Gln Ser Val Leu Ile Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Ser Ser Ser Asp Val Gly Ser Tyr
20 25 30
Asn Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Met Ile Tyr Glu Gly Tyr Lys Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Ser
85 90 95
Ser Ala Val Val Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1866
<211> 113
<212> PRT
<213> Homo sapiens
<400> 1866
Asp Ile Arg Val Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Glu Arg Ala Thr Ile Asn Cys Arg Thr Ser Gln Ser Val Leu Tyr Ser
20 25 30
Ser Asn Asn Lys Asn Tyr Leu Gly Trp Tyr Gln Gln Lys Pro Gly Gln
35 40 45
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln
85 90 95
Tyr Tyr Ser Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Asp Ile
100 105 110
Lys
<210> 1867
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1867
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro
65 70 75 80
Glu Asp Phe Ala Leu Tyr Tyr Cys Leu Gln Arg Ser Asp Trp His Pro
85 90 95
Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys
100 105
<210> 1868
<211> 109
<212> PRT
<213> Homo sapiens
<400> 1868
Asp Ile Gln Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Asn Gln Ser Val Ser Asn Phe
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg His Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro
85 90 95
Arg Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1869
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1869
Asp Ile Val Met Thr Gln Thr Pro Gly Thr Leu Ser Val Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ile Ile Asn Arg Ser
20 25 30
Gln Leu Gly Trp Tyr Gln His Lys Pro Gly Gln Pro Pro Arg Leu Leu
35 40 45
Ile Phe Asp Ser Ser Lys Arg Ala Thr Gly Thr Pro Asp Arg Phe Ser
50 55 60
Ala Ser Gly Ser Glu Thr Asp Phe Thr Leu Thr Ile Ser Gly Val Glu
65 70 75 80
Pro Glu Asp Ser Gly Val Tyr Tyr Cys Leu Gln Tyr Ser Leu Ala Thr
85 90 95
Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1870
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1870
Gln Pro Val Leu Thr Gln Ser Ser Ser Ala Ser Ala Ser Leu Gly Ser
1 5 10 15
Ser Val Lys Leu Thr Cys Thr Leu Ser Ser Gly His Ser Ser Tyr Ile
20 25 30
Leu Ala Trp His Gln Gln Gln Pro Gly Lys Ala Pro Arg Phe Leu Met
35 40 45
Lys Phe Glu Val Gly Gly Arg Tyr Asn Lys Gly Ser Gly Val Pro Asp
50 55 60
Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Thr Ile Ser
65 70 75 80
Asn Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Glu Thr Trp Asp
85 90 95
Ser Asn Leu Lys Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 1871
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1871
Gln Pro Val Leu Thr Gln Ser Ser Ser Ala Ser Ala Ser Leu Gly Ser
1 5 10 15
Ser Val Lys Leu Thr Cys Thr Leu Arg Ser Gly His Ser Ser Tyr Ile
20 25 30
Ile Ala Trp His Gln Gln Gln Pro Gly Lys Ala Pro Arg Phe Leu Met
35 40 45
Lys Val Gly His Ser Gly Ser Tyr Asn Lys Gly Ser Gly Val Pro Asp
50 55 60
Arg Phe Ser Gly Ser Arg Ser Gly Ala Asp His Tyr Leu Thr Ile Ser
65 70 75 80
Asn Leu Gln Pro Asp Asp Glu Ala Asp Tyr Tyr Cys Glu Ala Trp Asp
85 90 95
Asn Asn Asn Leu Gly Val Phe Ser Gly Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 1872
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1872
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Asn Asp Asn
20 25 30
Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Val Pro Lys Arg Leu Ile
35 40 45
Tyr Ala Ala Ser Asn Leu Gln Asn Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser Tyr Pro Leu
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1873
<211> 113
<212> PRT
<213> Homo sapiens
<400> 1873
Asp Ile Arg Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly
1 5 10 15
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser
20 25 30
Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala
85 90 95
Leu Gln Thr Pro Gly Val Thr Phe Gly Gly Gly Thr Lys Val Asp Ile
100 105 110
Lys
<210> 1874
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1874
Gln Pro Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Arg Val Thr Ile Ser Cys Ser Gly Ser Tyr Ser Asn Ile Gly Thr Asn
20 25 30
Pro Ala Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Asn Asn Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp Glu Thr Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
85 90 95
Asn Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1875
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1875
Asp Ile Arg Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Arg Gly
1 5 10 15
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser His Asn Val Val His Ser
20 25 30
Asp Gly Lys Thr Tyr Leu Asn Trp Phe His Gln Arg Pro Gly Gln Ala
35 40 45
Pro Arg Arg Leu Ile Tyr Gln Val Ser Lys Arg Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Phe Thr Leu Thr Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly
85 90 95
Thr Asp Trp Pro Arg Ser Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105 110
<210> 1876
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1876
Glu Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Ser Ile Ser Ser Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Leu His Thr Tyr Thr Thr Pro Arg
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1877
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1877
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
1 5 10 15
Glu Arg Ile Thr Leu Ser Cys Arg Ala Ser His Ser Val Ser Ser Asn
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Val Pro Arg Leu Leu Ile
35 40 45
Tyr Gly Ala Ser Ala Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Tyr Trp Pro Pro
85 90 95
Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1878
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1878
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Thr Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Thr Gly Lys Ala Pro Glu Leu Leu Ile
35 40 45
Tyr Val Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Arg Phe Pro Ile
85 90 95
Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys
100 105
<210> 1879
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1879
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Thr Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys His Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Ser Asp Val Ser Lys Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Ser Leu Glu Pro
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Thr Asn Trp Pro Gly
85 90 95
Ala Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys
100 105
<210> 1880
<211> 111
<212> PRT
<213> Homo sapiens
<400> 1880
Gln Pro Val Leu Thr Gln Ser Pro Ser Ala Ser Ala Ser Leu Gly Gly
1 5 10 15
Ser Val Lys Leu Thr Cys Thr Leu Thr Ser Gly His Ser Thr Tyr Ala
20 25 30
Ile Ala Trp His Gln Gln Gln Pro Glu Lys Gly Pro Arg Phe Leu Met
35 40 45
Lys Leu Asn Ser Asp Gly Ser His Asn Lys Gly Asp Gly Ile Pro Asp
50 55 60
Arg Phe Ser Gly Ser Ser Ser Gly Ala Glu Arg Tyr Leu Thr Ile Ser
65 70 75 80
Ser Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys His Thr Trp Gly
85 90 95
Thr Asp Ile Gln Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1881
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1881
Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys
1 5 10 15
Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Ile Ala Asn Asn
20 25 30
Tyr Val Gln Trp Leu Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr Ile
35 40 45
Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Ile Asp Ala Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly
65 70 75 80
Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser
85 90 95
Ser Ser Gln Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 1882
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1882
Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
1 5 10 15
Glu Arg Ile Thr Leu Ser Cys Arg Ala Ser His Ser Val Ser Ser Asn
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Val Pro Arg Leu Leu Ile
35 40 45
Tyr Gly Ala Ser Ala Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Tyr Trp Pro Pro
85 90 95
Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1883
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1883
Glu Thr Thr Leu Thr Gln Ser Pro Leu Ser Leu Ser Val Thr Leu Gly
1 5 10 15
Gln Ala Ala Ser Ile Ser Cys Arg Pro Asn Leu Gly Leu Met His Thr
20 25 30
Asp Gly Asn Thr Tyr Leu Asn Trp Phe His Gln Arg Pro Gly Gln Ser
35 40 45
Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Ala Gly Ser Gly Ser Gly Thr His Phe Thr Leu Glu Ile
65 70 75 80
Ser Gly Val Glu Ala Asp Asp Val Gly Val Tyr Tyr Cys Met Gln Gly
85 90 95
Thr Glu Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 1884
<211> 106
<212> PRT
<213> Homo sapiens
<400> 1884
Asp Ile Arg Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Gly Ser Trp
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile
35 40 45
Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Leu Tyr Thr
85 90 95
Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1885
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1885
Glu Thr Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Val Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ile Ser Asn
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Gly Ala Ser Thr Arg Ala Thr Gly Val Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ala Ser Leu Gln Ser
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr His His Trp Pro Pro
85 90 95
Tyr Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys
100 105
<210> 1886
<211> 114
<212> PRT
<213> Homo sapiens
<400> 1886
Glu Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser
20 25 30
Ser Asn Asn Glu Asn Cys Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
35 40 45
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln
85 90 95
Tyr Cys Ser Thr Pro Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Asp
100 105 110
Ile Lys
<210> 1887
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1887
Glu Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Ser Leu Gly
1 5 10 15
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Val Ile His Thr
20 25 30
Asp Gly Asn Thr Tyr Leu Asn Trp Tyr His Gln Arg Pro Gly Gln Ser
35 40 45
Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Val Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly
85 90 95
Thr Glu Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105 110
<210> 1888
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1888
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Ser Arg Gly
1 5 10 15
Gln Ser Ala Ser Ile Ser Cys Arg Ser Ser His Ser Val Val His Ser
20 25 30
Asp Gly Lys Thr Tyr Val Asn Trp Phe His Gln Arg Pro Gly Gln Ala
35 40 45
Pro Arg Arg Leu Ile Tyr Gln Val Ser Lys Arg Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Phe Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys Met Gln Gly
85 90 95
Thr Asp Trp Pro Arg Ser Phe Gly Gly Gly Thr Lys Val Asp Ile Lys
100 105 110
<210> 1889
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1889
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Asn Ile Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu
85 90 95
Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys
100 105
<210> 1890
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1890
Asp Ile Arg Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly
1 5 10 15
Gln Ala Ala Ser Ile Ser Cys Lys Ser Ser His Phe Ile Val His Thr
20 25 30
Asp Gly Asn Thr Tyr Leu Asn Trp Phe His Gln Arg Pro Gly Gln Ser
35 40 45
Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Glu Ile
65 70 75 80
Ser Gly Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly
85 90 95
Thr Glu Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys
100 105 110
<210> 1891
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1891
Glu Thr Thr Leu Thr Gln Ser Pro Leu Phe Leu Pro Val Thr Leu Gly
1 5 10 15
Gln Pro Ala Ser Ile Ser Cys Thr Ser Ser Val His Val Val His Ser
20 25 30
Asp Gly Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser
35 40 45
Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Tyr Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly
85 90 95
Thr Asp Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys
100 105 110
<210> 1892
<211> 106
<212> PRT
<213> Homo sapiens
<400> 1892
Glu Thr Thr Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Asn Asp Tyr
20 25 30
Leu Gly Trp Tyr Gln His Arg Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
His Asp Ala Ser Thr Arg Ala Pro Gly Ile Pro Val Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro
65 70 75 80
Glu Asp Ser Ala Val Tyr Tyr Cys Gln Gln Arg Phe Ser Trp Tyr Asn
85 90 95
Phe Gly Pro Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1893
<211> 111
<212> PRT
<213> Homo sapiens
<400> 1893
Gln Ser Val Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Ala Val Thr Ser Ser Asp Val Gly Ser Tyr
20 25 30
Asn Leu Val Ser Trp His Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Met Ile Tyr Glu Val Asn Lys Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Val Tyr Tyr Cys Cys Ser Tyr Gly Gly Arg
85 90 95
Ser Thr Ser Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1894
<211> 106
<212> PRT
<213> Homo sapiens
<400> 1894
Asp Ile Arg Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Asn Asp Tyr
20 25 30
Leu Gly Trp Tyr Gln His Arg Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
His Asp Ala Ser Thr Arg Ala Pro Gly Ile Pro Val Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro
65 70 75 80
Glu Asp Ser Ala Val Tyr Tyr Cys Gln Gln Arg Phe Ser Trp Tyr Asn
85 90 95
Phe Gly Pro Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1895
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1895
Gln Pro Val Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Thr Ser Asp Val Gly Gly Tyr
20 25 30
Asp Tyr Val Ser Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Lys Leu
35 40 45
Ile Ile Tyr Asp Val Ile Asn Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Asp Asp Glu Thr Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Gly
85 90 95
Gly Thr Leu Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1896
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1896
Asp Ile Gln Met Thr Gln Ser Pro Leu Ser Leu Pro Val Gly Leu Gly
1 5 10 15
Gln Ser Ala Ser Ile Ser Cys Arg Ser Ser Gln Trp Val Val His Thr
20 25 30
Asp Gly Asn Thr Tyr Leu Asn Trp Phe His Gln Arg Pro Gly Gln Ser
35 40 45
Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala
85 90 95
Thr Glu Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105 110
<210> 1897
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1897
Asp Ile Arg Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly
1 5 10 15
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Arg Ile Val His Thr
20 25 30
Asp Gly Asn Thr Tyr Leu Asn Trp Phe Leu Gln Arg Pro Gly Gln Ser
35 40 45
Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Met Gln Gly
85 90 95
Thr Glu Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys
100 105 110
<210> 1898
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1898
Asp Ile Gln Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly
1 5 10 15
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Arg Ile Val His Thr
20 25 30
Asp Gly Asn Thr Tyr Leu Asn Trp Phe Leu Gln Arg Pro Gly Gln Ser
35 40 45
Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Met Gln Gly
85 90 95
Thr Glu Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105 110
<210> 1899
<211> 113
<212> PRT
<213> Homo sapiens
<400> 1899
Glu Thr Thr Leu Thr Gln Ser Pro Leu Ser Leu Ser Val Thr Leu Gly
1 5 10 15
Gln Ser Ala Ser Ile Ser Cys Arg Ala Ser Gln Thr Val Val His Ser
20 25 30
Val Asp Gly Asn Thr Tyr Leu Asn Trp Phe His Gln Arg Pro Gly Gln
35 40 45
Ser Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val
50 55 60
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg
65 70 75 80
Ile Ser Arg Val Glu Ala Glu Asp Ile Gly Ile Tyr Tyr Cys Met Gln
85 90 95
Gly Thr Asp Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile
100 105 110
Lys
<210> 1900
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1900
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly
1 5 10 15
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Arg Ile Val His Thr
20 25 30
Asp Gly Asn Thr Tyr Leu Asn Trp Phe Leu Gln Arg Pro Gly Gln Ser
35 40 45
Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Met Gln Gly
85 90 95
Thr Glu Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105 110
<210> 1901
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1901
Asp Ile Arg Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly
1 5 10 15
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Phe Val Val His Thr
20 25 30
Asp Gly Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser
35 40 45
Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala
85 90 95
Thr Glu Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys
100 105 110
<210> 1902
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1902
Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
1 5 10 15
Thr Ala Arg Ile Thr Cys Ser Ala Asp Gly Leu Pro Lys Gln Tyr Ser
20 25 30
Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Met Val Ile Tyr
35 40 45
Lys Asp Thr Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Ser Ser Gly Thr Thr Ala Thr Leu Thr Ile Ser Gly Val Gln Ala Glu
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Ala Asp Ser Asn Asp Ser Ser
85 90 95
Pro Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu
100 105
<210> 1903
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1903
Glu Thr Thr Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Gly Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Arg Ser Asn Trp Pro Tyr
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1904
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1904
Asp Ile Val Leu Thr Gln Thr Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Ala Thr Tyr
20 25 30
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Val Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Gly Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ile Pro Trp
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys
100 105
<210> 1905
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1905
Glu Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Tyr Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Ile Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln His Ser Tyr Ser Ser Pro Pro
85 90 95
Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1906
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1906
Glu Thr Thr Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly
1 5 10 15
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ile Val Val His Ser
20 25 30
Asp Gly Asn Thr Tyr Leu Asn Trp Phe His Gln Arg Pro Gly Gln Ser
35 40 45
Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Ile Gly Val Tyr Tyr Cys Met Gln Gly
85 90 95
Thr Asp Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys
100 105 110
<210> 1907
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1907
Asp Ile Arg Leu Thr Gln Ser Pro Leu Ser Leu Ser Val Thr Leu Gly
1 5 10 15
Gln Ala Ala Ser Ile Ser Cys Thr Cys Ser Gln Thr Ala Val His Ser
20 25 30
Asp Gly Asn Thr Tyr Leu Asn Trp Phe His Gln Arg Pro Gly Gln Ser
35 40 45
Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Met Gln Thr
85 90 95
Thr Asp Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105 110
<210> 1908
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1908
Glu Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly
1 5 10 15
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Leu Arg Leu Val His Thr
20 25 30
Asp Gly Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser
35 40 45
Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Ile Gly Val Tyr Tyr Cys Met Gln Gly
85 90 95
Thr Glu Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys
100 105 110
<210> 1909
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1909
Asp Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Ala Leu Ser Cys Arg Ala Ser Gln Ile Val Thr Arg Ser
20 25 30
Gln Leu Ala Trp Tyr Gln His Lys Pro Gly Gln Pro Pro Arg Leu Leu
35 40 45
Ile Tyr Asp Ser Ser Ser Arg Ala Thr Gly Thr Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65 70 75 80
Pro Glu Asp Ser Ala Val Tyr Tyr Cys His Gln Tyr Ser Gly Ser Ala
85 90 95
Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1910
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1910
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Arg Gln
1 5 10 15
Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ala Asn Ile Ala Ser Asn
20 25 30
Gly Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Tyr Asp Asp Leu Val Ser Ser Gly Val Ser Asp Arg Phe Ser
50 55 60
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ile Leu
85 90 95
Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1911
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1911
Asp Ile Arg Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Phe Gly Asn Lys
20 25 30
Val Ala Trp Tyr Gln Gln Lys Pro Gly Thr Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Glu Thr Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Ala Phe Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Gly Ala Thr Tyr Tyr Cys Gln Lys Tyr Asn Arg Ala Pro Trp
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1912
<211> 111
<212> PRT
<213> Homo sapiens
<400> 1912
Gln Ser Ala Leu Ile Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Arg Tyr
20 25 30
Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Ala Tyr Tyr Cys Ser Ser Tyr Ile Ser Asp
85 90 95
Ile Lys Leu Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1913
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1913
Gln Ser Ala Leu Ile Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Ser
20 25 30
Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Leu Val Tyr Asp Val Thr Lys Arg Pro Ser Gly Val Pro Asp Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Thr
85 90 95
Tyr Ile Phe Gly Thr Gly Thr Lys Leu Thr Val Leu
100 105
<210> 1914
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1914
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Val Ser Ile Ser Cys Ser Gly Thr Ser Ser Asp Phe Gly Asn Tyr
20 25 30
Asn Arg Ile Ser Trp Tyr Gln Gln Thr Pro Gly Thr Ala Pro Lys Val
35 40 45
Ile Ile Tyr Glu Val Asn Ser Arg Pro Ser Gly Val Pro Asp Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Arg Ser Asp
85 90 95
Asn Thr Tyr Ile Phe Gly Gly Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 1915
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1915
Glu Thr Thr Leu Thr Gln Ser Pro Leu Phe Leu Pro Val Thr Leu Gly
1 5 10 15
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Arg Leu Val His Thr
20 25 30
Asn Gly Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly His Ser
35 40 45
Pro Arg Arg Leu Ile Tyr Gln Val Ser Asn Arg Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly
85 90 95
Thr Glu Trp Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 1916
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1916
Gln Pro Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
1 5 10 15
Arg Val Thr Ile Ser Cys Ser Gly Gly Ser Ser Asn Ile Gly Ser Asn
20 25 30
Ser Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Ser Asn Ser Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu
85 90 95
Asn Thr Phe Arg Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 1917
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1917
Glu Thr Thr Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Asn Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Thr Tyr
20 25 30
Leu Thr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Gly Ala Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Thr Gly
50 55 60
Val Gly Ser Gly Thr Glu Phe Thr Leu Ser Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Asn Thr Phe Phe
85 90 95
Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys
100 105
<210> 1918
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1918
Asp Ile Arg Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ala Ile Ala Gly Trp
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Arg Ala Pro Lys Ser Leu Ile
35 40 45
Tyr Arg Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Ser Asn Leu Gln Pro
65 70 75 80
Glu Asp Ser Ala Thr Tyr Tyr Cys Gln His Tyr Asp Ser Tyr Pro Thr
85 90 95
Ala Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys
100 105
<210> 1919
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1919
Glu Thr Gly Leu Thr Gln Ile Pro Phe Ser Leu Pro Val Thr Phe Gly
1 5 10 15
Gln Pro Ala Ser Ile Ser Cys Arg Phe Ser Gln Arg Leu Val His Thr
20 25 30
Asp Gly Asn Thr Asn Leu Asn Trp Phe Leu Gln Arg Pro Gly Gln Phe
35 40 45
Pro Arg Gly Leu Ile Tyr Lys Val Phe Asn Arg Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Arg Gly Ser Gly Ser Gly Ile Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Val Glu Asp Val Gly Ile Tyr Tyr Gly Met Gln Gly
85 90 95
Thr Glu Trp Leu Gly Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105 110
<210> 1920
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1920
Glu Thr Thr Leu Thr Gln Ser Pro Leu Ser Leu Ala Val Thr Leu Gly
1 5 10 15
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Leu Gly Leu Val His Thr
20 25 30
Asn Gly Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser
35 40 45
Pro Arg Arg Leu Ile Tyr Arg Val Ser Asn Arg Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Val Thr Asp Phe Thr Leu Thr Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Ile Gly Val Tyr Tyr Cys Met Gln Gly
85 90 95
Thr Glu Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105 110
<210> 1921
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1921
Glu Thr Thr Leu Thr Gln Ser Pro Leu Ser Leu Ser Val Thr Leu Gly
1 5 10 15
Gln Ala Ala Ser Ile Ser Cys Thr Cys Ser Gln Thr Ala Val His Ser
20 25 30
Asp Gly Asn Thr Tyr Leu Asn Trp Phe His Gln Arg Pro Gly Gln Ser
35 40 45
Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Met Gln Thr
85 90 95
Thr Asp Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys
100 105 110
<210> 1922
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1922
Glu Ile Val Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Gly Gln Ser Ile Ser Thr Asn
20 25 30
Leu Cys Trp Tyr Gln Gln Arg Gln Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Arg Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro
85 90 95
Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys
100 105
<210> 1923
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1923
Asp Ile Gln Val Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
1 5 10 15
Glu Arg Val Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asn Thr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Tyr Asn Lys Trp Pro Pro
85 90 95
Ile Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1924
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1924
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Gly Ile Ser Thr Phe
20 25 30
Leu Ala Trp Phe Gln Gln Arg Pro Gly Lys Ala Pro Lys Ser Leu Ile
35 40 45
Tyr Ala Ala Ser Lys Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Asp Ser Gly Pro Asp Phe Thr Leu Thr Ile Asp Asn Leu Arg Pro
65 70 75 80
Glu Asp Ser Ala Thr Tyr Tyr Cys Lys Gln Tyr Asn Ser Tyr Pro Tyr
85 90 95
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1925
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1925
Glu Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Ser Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asn Tyr
20 25 30
Leu Asn Trp Tyr Gln Asp Lys Pro Gly Lys Ala Pro Glu Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Asp Ser Trp
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys
100 105
<210> 1926
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1926
Glu Thr Thr Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly
1 5 10 15
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Arg Ile Val His Thr
20 25 30
Asp Gly Asn Thr Tyr Leu Asn Trp Phe Leu Gln Arg Pro Gly Gln Ser
35 40 45
Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Met Gln Gly
85 90 95
Thr Glu Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105 110
<210> 1927
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1927
Asp Ile Gln Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly
1 5 10 15
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Val Val His Ser
20 25 30
Asp Gly Asn Thr Tyr Leu Asn Trp Phe His Gln Arg Pro Gly Gln Ser
35 40 45
Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Ile Gly Val Tyr Tyr Cys Met Gln Gly
85 90 95
Thr Asp Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys
100 105 110
<210> 1928
<211> 113
<212> PRT
<213> Homo sapiens
<400> 1928
Gly Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Val Gly
1 5 10 15
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Thr Val Leu Tyr Ser
20 25 30
Ser Lys Asn Lys His Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
35 40 45
Pro Pro Lys Leu Leu Thr Ser Ser Pro Ser Thr Arg Glu Pro Gly Val
50 55 60
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln
85 90 95
Tyr Tyr Thr Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Asp Ile
100 105 110
Lys
<210> 1929
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1929
Glu Ile Val Met Thr Gln Thr Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asn Tyr
20 25 30
Val Asn Trp Tyr Gln Gln Lys Pro Gly Arg Ala Pro Asn Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Ser Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Tyr Ser Thr Pro Pro
85 90 95
Glu Gly Pro Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys
100 105 110
<210> 1930
<211> 115
<212> PRT
<213> Homo sapiens
<400> 1930
Gln Pro Val Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr
20 25 30
Ser Asp Val Gly Asn Tyr Val Ser Trp Tyr Gln His His Pro Gly Lys
35 40 45
Ala Pro Lys Leu Met Ile Tyr Glu Val Arg Thr Arg Pro Ser Trp Val
50 55 60
Ser Thr Arg Phe Ser Gly Ser Lys Ser Gly Thr Thr Ala Ser Leu Thr
65 70 75 80
Ile Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser
85 90 95
Tyr Ala Gly Ala Ser Pro Phe Val Val Phe Gly Gly Gly Thr Lys Leu
100 105 110
Thr Val Leu
115
<210> 1931
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1931
Glu Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Ser Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Arg
20 25 30
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
35 40 45
Ile Tyr Gly Thr Ser Asn Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65 70 75 80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Tyr
85 90 95
Thr Phe Gly Pro Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1932
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1932
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Gly Leu Gly
1 5 10 15
Gln Ser Ala Ser Ile Ser Cys Arg Ser Ser Gln Arg Val Val His Thr
20 25 30
Asp Gly Asn Thr Tyr Leu Asn Trp Phe His Gln Arg Pro Gly Gln Ser
35 40 45
Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala
85 90 95
Thr Glu Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105 110
<210> 1933
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1933
Asp Ile Arg Leu Thr Gln Ser Pro Leu Ser Leu Ser Val Thr Leu Gly
1 5 10 15
Gln Ala Ala Ser Ile Ser Cys Thr Cys Ser Gln Ser Ala Val His Ser
20 25 30
Asp Gly Thr Thr Tyr Phe Asn Trp Phe His Gln Arg Pro Gly Gln Ser
35 40 45
Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr His Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Thr
85 90 95
Thr Asp Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105 110
<210> 1934
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1934
Glu Thr Thr Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly
1 5 10 15
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Val Val His Ser
20 25 30
Asp Gly Asn Thr Tyr Leu Asn Trp Phe His Gln Arg Pro Gly Gln Ser
35 40 45
Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Ile Gly Val Tyr Tyr Cys Met Gln Gly
85 90 95
Thr Asp Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105 110
<210> 1935
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1935
Glu Thr Thr Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly
1 5 10 15
Gln Pro Ala Ser Ile Ser Cys Thr Ser Ser Gln Thr Val Val His Thr
20 25 30
Asp Arg Asn Thr Tyr Leu Asn Trp Tyr His Gln Arg Pro Gly Gln Ser
35 40 45
Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Ser His Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly
85 90 95
Thr Glu Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 1936
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1936
Gln Pro Gly Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Gly Asp Val Gly Ser Asp
20 25 30
Asn Leu Val Ser Trp Tyr Gln Arg His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Met Ile Tyr Glu Gly Ser Lys Arg Pro Ser Gly Val Ser His Arg Phe
50 55 60
Ser Gly Ser Asn Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Asp Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Asp
85 90 95
Asp Thr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1937
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1937
Asp Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Val Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Ser Asn
20 25 30
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
35 40 45
Ile Ser Asp Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Ala Asp Phe Thr Leu Ile Ile Ser Arg Leu Glu
65 70 75 80
Pro Glu Asp Phe Ala Val Tyr Phe Cys His Gln Tyr Gly Gly Ser Pro
85 90 95
Thr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1938
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1938
Glu Thr Thr Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly
1 5 10 15
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ile Ala Met His Ser
20 25 30
Asp Gly Asn Thr Tyr Leu Ser Trp Phe His Gln Arg Pro Gly Gln Pro
35 40 45
Pro Arg Arg Leu Ile Tyr Lys Ile Ser Asn Arg Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Ile Gly Thr Phe Tyr Cys Met Gln Gly
85 90 95
Thr Asp Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105 110
<210> 1939
<211> 106
<212> PRT
<213> Homo sapiens
<400> 1939
Glu Thr Thr Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Asp Ala Phe Asn Arg Ala Thr Gly Val Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Thr Ser Thr Leu Thr
85 90 95
Phe Gly Gly Gly Thr Lys Val Asp Ile Lys
100 105
<210> 1940
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1940
Glu Thr Thr Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly
1 5 10 15
Gln Ala Ala Ser Ile Ser Cys Arg Ser Ser Gln Ala Val Val His Ser
20 25 30
Asp Gly Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Pro
35 40 45
Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Val Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Ile Gly Val Tyr Tyr Cys Met Gln Gly
85 90 95
Thr Glu Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105 110
<210> 1941
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1941
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln
1 5 10 15
Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Leu Gly Asn Asn
20 25 30
Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Asp Asn His Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln
65 70 75 80
Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Glu Thr Trp Asp Ser Ser Leu
85 90 95
Ser Val Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 1942
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1942
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Thr Pro Gly Gln
1 5 10 15
Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn
20 25 30
Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln
65 70 75 80
Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Arg Leu
85 90 95
Ser Ala Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1943
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1943
Asp Ile Arg Val Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Asn Ile Ala His Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Val Ile
35 40 45
Tyr Asp Ala Ser Ser Arg Ala Thr Gly Ile Pro Gly Arg Phe Ser Gly
50 55 60
Ser Gly Ala Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Pro
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Gln
85 90 95
Asn Phe Gly Gly Gly Thr Lys Val Asp Ile Lys
100 105
<210> 1944
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1944
Asp Ile Arg Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Ser Trp
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Ser Gly Lys Ala Pro Lys Ser Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Asn Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Leu Gly Thr Tyr Tyr Cys Gln Gln Tyr Asp Ser Tyr Pro Val
85 90 95
Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys
100 105
<210> 1945
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1945
Asp Ile Val Leu Thr Gln Thr Pro Asp Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser
20 25 30
Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
35 40 45
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln
85 90 95
Tyr Tyr Thr Met Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105 110
<210> 1946
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1946
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln
1 5 10 15
Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asp
20 25 30
Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Glu Asn Tyr Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Asp Ile Thr Gly Leu Gln
65 70 75 80
Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu
85 90 95
Ser Val Asp Asn Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1947
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1947
Asp Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly
1 5 10 15
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Val Val His Ser
20 25 30
Asp Gly Asn Thr Tyr Leu Asn Trp Phe His Gln Arg Pro Gly Gln Ser
35 40 45
Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Ile Gly Val Tyr Tyr Cys Met Gln Gly
85 90 95
Thr Asp Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys
100 105 110
<210> 1948
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1948
Glu Thr Thr Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly
1 5 10 15
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Val Leu Val His Ser
20 25 30
Asp Gly Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser
35 40 45
Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Ile Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Ile Gly Val Tyr Tyr Cys Met Gln Gly
85 90 95
Thr Glu Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys
100 105 110
<210> 1949
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1949
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser His Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Asn Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Ser Tyr Ser Thr Pro Leu
85 90 95
Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys
100 105
<210> 1950
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1950
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Asn Ile Ala His Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Val Ile
35 40 45
Tyr Asp Ala Ser Ser Arg Ala Thr Gly Ile Pro Gly Arg Phe Ser Gly
50 55 60
Ser Gly Ala Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Pro
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Gln
85 90 95
Asn Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1951
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1951
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln
1 5 10 15
Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly
20 25 30
Tyr Tyr Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu
35 40 45
Leu Ile Tyr Asp Asn Asn Asn Arg Pro Ser Gly Val Pro Asp Arg Phe
50 55 60
Ser Gly Ser Arg Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Gly Asp Tyr Phe Cys Gln Ser Tyr Asp Ser Ser
85 90 95
Leu Ser Ala Ser Phe Gly Gly Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 1952
<211> 111
<212> PRT
<213> Homo sapiens
<400> 1952
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln
1 5 10 15
Arg Val Thr Ile Ser Cys Thr Gly Ser Asn Ser Asn Ile Gly Ala Gly
20 25 30
Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Glu Thr Ala Pro Lys Leu
35 40 45
Leu Ile Tyr Ala Asn Gly Asn Arg Pro Ser Gly Val Pro Asp Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser
85 90 95
Leu Ser Gly Val Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1953
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1953
Asp Ile Gln Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly
1 5 10 15
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln His Leu Val His Ser
20 25 30
Asp Gly Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser
35 40 45
Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Ile Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Ile Gly Val Tyr Tyr Cys Met Gln Gly
85 90 95
Thr Glu Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105 110
<210> 1954
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1954
Asp Ile Gln Val Thr Gln Ser Pro Ala Thr Val Ser Val Ser Pro Gly
1 5 10 15
Glu Gly Ala Ser Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Ser Asn
20 25 30
Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Ser Asp Ala Ser Thr Arg Ala Ser Gly Val Pro Ala Arg Phe Thr Gly
50 55 60
Ser Gly Phe Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
65 70 75 80
Glu Asp Phe Ala Ile Tyr Tyr Cys Gln Gln Tyr Asn Thr Trp Pro Pro
85 90 95
Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1955
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1955
Asp Ile Arg Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly
1 5 10 15
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser
20 25 30
Asn Gly Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser
35 40 45
Pro Arg Arg Leu Ile Tyr Glu Val Ser Asn Arg Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly
85 90 95
Thr His Trp Pro Arg Ser Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105 110
<210> 1956
<211> 109
<212> PRT
<213> Homo sapiens
<400> 1956
Glu Thr Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Gly Ser Ser
20 25 30
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
35 40 45
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65 70 75 80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ala Pro
85 90 95
Leu Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1957
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1957
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Ser Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser
20 25 30
Tyr Leu Ala Trp Tyr Gln His Arg Pro Gly Gln Ala Pro Arg Leu Leu
35 40 45
Ile Tyr Asp Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65 70 75 80
Ser Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Asn Ser Pro
85 90 95
Arg Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys
100 105
<210> 1958
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1958
Gln Pro Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln
1 5 10 15
Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asp Asn
20 25 30
Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln
65 70 75 80
Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Glu Thr Trp Asp Thr Ser Leu
85 90 95
Ser Val Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1959
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1959
Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ala Val Thr Leu Gly
1 5 10 15
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser His Gly Leu Val His Thr
20 25 30
Asn Gly Asn Thr Tyr Leu Asn Trp Phe His Gln Arg Pro Gly Gln Pro
35 40 45
Pro Arg Arg Leu Ile Tyr Lys Ile Ser Asn Arg Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Asp Asp Val Gly Val Tyr Tyr Cys Met Gln Gly
85 90 95
Thr Asp Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105 110
<210> 1960
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1960
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Val Thr Arg Ser
20 25 30
Gln Leu Ala Trp Tyr Gln His Lys Pro Gly Gln Pro Pro Arg Leu Leu
35 40 45
Ile Tyr Asp Ser Ser Lys Arg Ala Thr Gly Ser Pro Asp Arg Phe Ser
50 55 60
Ala Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Gly Leu Glu
65 70 75 80
Pro Glu Asp Thr Gly Ile Tyr Tyr Cys Leu Gln Tyr Ser Asp Ala Thr
85 90 95
Thr Phe Gly Pro Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1961
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1961
Glu Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Ile Gly
1 5 10 15
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asn Ile Gly Ser Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Asn Leu Leu Ile
35 40 45
Phe Val Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Thr Thr Pro Ile
85 90 95
Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys
100 105
<210> 1962
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1962
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Gly Leu Gly
1 5 10 15
Gln Ser Ala Ser Ile Ser Cys Arg Ser Ser Gln Arg Val Val His Thr
20 25 30
Asp Gly Asn Thr Tyr Leu Asn Trp Phe His Gln Arg Pro Gly Gln Ser
35 40 45
Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala
85 90 95
Thr Glu Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105 110
<210> 1963
<211> 109
<212> PRT
<213> Homo sapiens
<400> 1963
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Asn Phe
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Arg Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Arg Ala Ser Gly Ile Ala Ala Arg Phe Ser Gly
50 55 60
Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Arg Asn Trp Pro Pro
85 90 95
Met Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 1964
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1964
Glu Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Ser Val Thr Leu Gly
1 5 10 15
Gln Ala Ala Ser Ile Ser Cys Thr Cys Ser Gln Thr Ala Val His Ser
20 25 30
Asp Gly Asn Thr Tyr Leu Asn Trp Phe His Gln Arg Pro Gly Gln Ser
35 40 45
Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Met Gln Thr
85 90 95
Thr Asp Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 1965
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1965
Glu Thr Thr Leu Thr Gln Ser Pro Leu Ser Leu Ser Val Thr Leu Gly
1 5 10 15
Gln Ala Ala Ser Ile Ser Cys Thr Cys Ser Gln Ser Ala Val His Ser
20 25 30
Asp Gly Asn Thr Tyr Phe Asn Trp Phe His Gln Arg Pro Gly Gln Ser
35 40 45
Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro
50 55 60
Glu Arg Phe Ser Gly Ser Gly Ser Gly Thr His Phe Thr Leu Ile Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Thr
85 90 95
Thr Asp Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys
100 105 110
<210> 1966
<211> 111
<212> PRT
<213> Homo sapiens
<400> 1966
Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys
1 5 10 15
Ala Val Ile Ile Ser Cys Thr Arg Ser Ser Gly Asn Ile Ala Ser Asn
20 25 30
Phe Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Thr Pro Val
35 40 45
Ile Tyr Glu Asp Lys Leu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Ile Asp Arg Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly
65 70 75 80
Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser
85 90 95
Gly Asn Leu Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1967
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1967
Asp Ile Gln Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly
1 5 10 15
Gln Ala Ala Ser Ile Ser Cys Arg Ser Ser Gln Pro Ile Pro His Thr
20 25 30
Asp Gly Asn Thr Tyr Leu Asn Trp Phe His Gln Arg Pro Gly Gln Ser
35 40 45
Pro Arg Arg Leu Ile His Lys Val Ser Asn Arg Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Leu Asp Phe Thr Leu Glu Ile
65 70 75 80
Ser Gly Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Met Gln Gly
85 90 95
Thr Glu Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105 110
<210> 1968
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1968
Glu Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Leu Gly
1 5 10 15
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser His Gly Leu Val His Thr
20 25 30
Asn Gly Asn Thr Tyr Leu Asn Trp Phe His Gln Arg Pro Gly Gln Pro
35 40 45
Pro Arg Arg Leu Ile Tyr Gln Val Ser His Arg Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Asp Asp Val Gly Val Tyr Tyr Cys Met Gln Gly
85 90 95
Thr Asp Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys
100 105 110
<210> 1969
<211> 109
<212> PRT
<213> Homo sapiens
<400> 1969
Glu Thr Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Asn Asn
20 25 30
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
35 40 45
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65 70 75 80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Thr Ser Pro
85 90 95
Val Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1970
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1970
Asp Ile Gln Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly
1 5 10 15
Gln Pro Ala Ser Ile Ser Cys Thr Ser Ser Gln Asn Val Val His Thr
20 25 30
Asp Gly Asn Thr Tyr Leu Asn Trp Phe His Gln Arg Pro Gly Gln Ser
35 40 45
Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Ser His Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Met Gln Gly
85 90 95
Thr Asp Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105 110
<210> 1971
<211> 109
<212> PRT
<213> Homo sapiens
<400> 1971
Asp Ile Val Leu Thr Gln Thr Pro Ala Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Asn Phe
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Arg Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Asn Arg Ala Ser Gly Ile Ala Ala Arg Phe Ser Gly
50 55 60
Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Arg Asn Trp Pro Pro
85 90 95
Met Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1972
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1972
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln
1 5 10 15
Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly
20 25 30
Tyr Asp Val His Trp Tyr Gln Gln Val Pro Gly Thr Ala Pro Lys Leu
35 40 45
Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser
85 90 95
Leu Ser Val Leu Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 1973
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1973
Asp Ile Arg Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Gly Tyr Tyr
20 25 30
Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Lys Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Arg Thr Asn Trp Pro Tyr
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1974
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1974
Gln Pro Gly Leu Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly
1 5 10 15
Thr Val Thr Leu Thr Cys Gly Ser Ser Ala Gly Ala Val Thr Ser Gly
20 25 30
His Tyr Pro Tyr Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Arg Thr
35 40 45
Leu Ile Tyr Asp Thr Asn Asn Lys Tyr Ser Trp Thr Pro Ala Arg Phe
50 55 60
Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Ala
65 70 75 80
Gln Pro Glu Asp Glu Ala Glu Tyr Phe Cys Phe Leu Ser Tyr Arg Gly
85 90 95
Ala Pro Pro Val Phe Gly Gly Gly Thr His Leu Thr Val Leu
100 105 110
<210> 1975
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1975
Asp Ile Arg Met Thr Gln Ser Pro Phe Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Phe Gly Asn Arg
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Arg Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Glu Thr Asp Phe Ala Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Val Ala Thr Tyr Tyr Cys Gln Lys His Asp Arg Asp Pro Trp
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1976
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1976
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly
1 5 10 15
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Arg Leu Val His Ser
20 25 30
Asp Gly Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser
35 40 45
Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Ile Gly Val Tyr Tyr Cys Met Gln Gly
85 90 95
Thr Glu Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105 110
<210> 1977
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1977
Glu Thr Thr Leu Thr Gln Ser Pro Ala Ser Val Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Gly Ile Gly Arg Trp
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Arg Ala Pro Lys Leu Leu Ile
35 40 45
Phe Ser Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Glu Ser Phe Pro Phe
85 90 95
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1978
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1978
Glu Thr Thr Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Asp Leu Gly
1 5 10 15
Gln Ser Ala Ser Ile Ser Cys Arg Ser Ser Gln Arg Val Val His Thr
20 25 30
Asn Gly Asn Thr Tyr Leu His Trp Phe His Gln Arg Pro Gly Gln Ala
35 40 45
Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Glu Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala
85 90 95
Thr Asp Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105 110
<210> 1979
<211> 106
<212> PRT
<213> Homo sapiens
<400> 1979
Cys Ile Arg Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Thr Ser Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Asp Thr Ser Asn Arg Val Thr Gly Val Pro Val Arg Phe Ser Gly
50 55 60
Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Gly Asn Gly Tyr Thr
85 90 95
Phe Gly Pro Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1980
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1980
Glu Thr Thr Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Gly Leu Gly
1 5 10 15
Gln Ser Ala Ser Ile Ser Cys Arg Ser Ser Gln Arg Val Val His Thr
20 25 30
Asp Gly Asn Thr Tyr Leu Asn Trp Phe His Gln Arg Pro Gly Gln Ser
35 40 45
Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala
85 90 95
Thr Glu Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys
100 105 110
<210> 1981
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1981
Glu Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly
1 5 10 15
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Val Val His Ser
20 25 30
Asp Gly Asn Thr Tyr Leu Asn Trp Phe His Gln Arg Pro Gly Gln Ser
35 40 45
Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Ile Gly Val Tyr Tyr Cys Met Gln Gly
85 90 95
Thr Asp Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 1982
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1982
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Asp Leu Gly
1 5 10 15
Gln Ser Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ala Val His Thr
20 25 30
Asn Gly Asn Thr Tyr Leu His Trp Phe His Gln Arg Pro Gly Gln Ala
35 40 45
Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Glu Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile
65 70 75 80
Asn Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala
85 90 95
Thr Asp Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 1983
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1983
Asp Ile Val Leu Thr Gln Thr Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Ser Tyr Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Val Gly Lys Ala Pro Gln Leu Leu Val
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Val Pro Leu
85 90 95
Thr Leu Gly Gln Gly Thr Lys Val Asp Ile Lys
100 105
<210> 1984
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1984
Asp Ile Gln Met Thr Gln Ser Pro Leu Ser Leu Pro Val Asp Leu Gly
1 5 10 15
Gln Ser Ala Ser Ile Ser Cys Arg Ser Ser Gln Arg Val Val His Thr
20 25 30
Asn Gly Asn Thr Tyr Leu His Trp Phe His Gln Arg Pro Gly Gln Ala
35 40 45
Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Glu Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala
85 90 95
Thr Asp Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105 110
<210> 1985
<211> 113
<212> PRT
<213> Homo sapiens
<400> 1985
Gln Pro Gly Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Arg Thr Ser Gly Asp Val Gly Asp Tyr
20 25 30
Asn Ser Val Ser Trp Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Arg
35 40 45
Ala Pro Lys Leu Met Leu Tyr Asp Val Ser Asn Arg Pro Ser Gly Val
50 55 60
Ser Asn Arg Phe Ser Gly Ser Lys Leu Gly Asp Thr Ala Ser Leu Thr
65 70 75 80
Ile Ser Glu Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Thr
85 90 95
Tyr Thr Ser Thr Ser Thr Ile Phe Gly Gly Gly Thr Lys Leu Thr Val
100 105 110
Leu
<210> 1986
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1986
Asp Ile Gln Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly
1 5 10 15
Gln Pro Ala Ser Ile Ser Cys Arg Ala Ser Gln Thr Val Val His Thr
20 25 30
Asn Gly Asn Thr Tyr Leu Asn Trp Phe His Gln Arg Pro Gly Gln Ser
35 40 45
Pro Arg Arg Leu Ile Tyr Glu Val Ser Asn Arg Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Ile Gly Val Tyr Tyr Cys Met Gln Gly
85 90 95
Thr Asp Trp Pro Arg Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys
100 105 110
<210> 1987
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1987
Asp Ile Arg Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Asp Leu Gly
1 5 10 15
Gln Ser Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Val Val His Thr
20 25 30
Asn Gly Asn Thr Tyr Leu His Trp Phe His Gln Arg Pro Gly Gln Ala
35 40 45
Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Glu Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala
85 90 95
Thr Asp Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys
100 105 110
<210> 1988
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1988
Asp Ile Arg Val Thr Gln Ser Pro Ser Ser Leu Ser Ala Thr Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Thr Lys Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Leu
35 40 45
Tyr Gly Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Tyr Ile Thr Pro Gly
85 90 95
Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys
100 105
<210> 1989
<211> 113
<212> PRT
<213> Homo sapiens
<400> 1989
Asp Ile Arg Leu Thr Gln Ser Pro Asp Ser Leu Ala Leu Ser Leu Gly
1 5 10 15
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Phe Ser
20 25 30
Ser Asn Asn Asn Asn Tyr Leu Gly Trp Tyr Gln Gln Lys Pro Gly Gln
35 40 45
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln
85 90 95
Tyr Tyr Leu Thr Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Asp Ile
100 105 110
Lys
<210> 1990
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1990
Gln Pro Val Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Asn Tyr
20 25 30
Asn Val Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Gln Leu
35 40 45
Phe Ile Tyr Glu Asp Thr Lys Arg Pro Ser Gly Val Ser Asp Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Ile Thr Ala Ser Leu Thr Ile Ser Arg Leu
65 70 75 80
Gln Pro Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Val Ser
85 90 95
Gly Thr Val Leu Phe Gly Gly Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 1991
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1991
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Val Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ile Ile Asn Arg Ser
20 25 30
Gln Leu Gly Trp Tyr Gln His Lys Pro Gly Gln Ala Pro Arg Leu Leu
35 40 45
Ile Phe Asp Ser Ser Lys Arg Ala Thr Gly Thr Pro Asp Arg Phe Ser
50 55 60
Ala Ser Gly Ser Glu Thr Asp Phe Thr Leu Thr Ile Ser Gly Val Glu
65 70 75 80
Pro Glu Asp Ser Gly Val Tyr Tyr Cys Leu Gln Tyr Ser Leu Ala Thr
85 90 95
Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys
100 105
<210> 1992
<211> 106
<212> PRT
<213> Homo sapiens
<400> 1992
Asp Ile Gln Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Pro Ser Val Phe Thr Phe
20 25 30
Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln Pro Pro Arg Leu Leu Ile
35 40 45
His Asp Val Ser Asn Arg Ala Pro Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Ile Ile Ser Ser Leu Glu Pro
65 70 75 80
Asp Asp Ser Ala Val Tyr Phe Cys Gln Gln Arg Ser Asp Gly Tyr Asn
85 90 95
Phe Gly Pro Gly Thr Lys Val Asp Ile Lys
100 105
<210> 1993
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1993
Asp Ile Arg Val Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Asn Asn Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Thr Leu Gln Asn Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Tyr Ile Thr Pro Thr
85 90 95
Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 1994
<211> 107
<212> PRT
<213> Homo sapiens
<400> 1994
Glu Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asn Tyr
20 25 30
Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Val Ala Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Tyr
85 90 95
Asn Phe Gly Gln Gly Thr Lys Val Asp Ile Lys
100 105
<210> 1995
<211> 106
<212> PRT
<213> Homo sapiens
<400> 1995
Glu Ile Val Leu Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Val Asn Asn Trp
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Glu Ala Ser Thr Leu Lys Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Gln Tyr Thr
85 90 95
Phe Gly Gln Gly Thr Lys Val Asp Ile Lys
100 105
<210> 1996
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1996
Gln Pro Val Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Thr Phe Gly Thr Asp
20 25 30
Asn His Ile Ser Trp Tyr Gln Gln Leu Pro Gly Lys Val Pro Lys Leu
35 40 45
Ile Ile His Ala Val Ser Gln Arg Pro Ser Val Val Pro Asp Arg Phe
50 55 60
Ser Gly Ser Arg Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Ser Pro Gly Thr
85 90 95
Ile Thr Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 1997
<211> 110
<212> PRT
<213> Homo sapiens
<400> 1997
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Val Pro Arg Gln
1 5 10 15
Lys Val Thr Ile Ser Cys Ser Gly Ser Thr Ala Asn Ile Ala Ser Asn
20 25 30
Gly Val Asn Trp Tyr Gln Leu Val Pro Gly Lys Ala Pro Arg Leu Leu
35 40 45
Ile Ser Tyr Asp Asp Leu Val Pro Ser Gly Val Ser Ala Arg Phe Ser
50 55 60
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ile Leu
85 90 95
Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 1998
<211> 112
<212> PRT
<213> Homo sapiens
<400> 1998
Asp Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly
1 5 10 15
Gln Ser Ala Ser Ile Ser Cys Arg Ser Ser Gln Gly Leu Val His Ser
20 25 30
Asp Gly Asn Ile Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser
35 40 45
Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Leu Tyr Tyr Cys Met Gln Ala
85 90 95
Thr His Trp Pro Arg Ala Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 1999
<211> 108
<212> PRT
<213> Homo sapiens
<400> 1999
Glu Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Val Thr Leu Ser Cys Arg Ala Thr Gln Ser Val Ser Asn Asn
20 25 30
His Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
35 40 45
Ile Tyr Gly Ala Ser Thr Thr Ala Thr Asp Ile Pro Asp Arg Phe Ser
50 55 60
Gly Arg Val Ala Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Asp
65 70 75 80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Tyr Gly Ser Ser Pro
85 90 95
Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 2000
<211> 109
<212> PRT
<213> Homo sapiens
<400> 2000
Asp Ile Arg Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Glu Ala Ser Asn Arg Ala Thr Gly Val Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Ala Ile Ser Ser Leu Glu Pro
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Arg Ser Asn Trp Pro Pro
85 90 95
Arg Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 2001
<211> 108
<212> PRT
<213> Homo sapiens
<400> 2001
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
1 5 10 15
Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Arg Arg Tyr Ala
20 25 30
Tyr Trp Tyr Gln Gln Arg Ser Gly Gln Ala Pro Val Leu Val Ile Tyr
35 40 45
Glu Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Ala Phe
50 55 60
Ser Ser Gly Thr Arg Ala Thr Leu Thr Ile Ser Gly Ala Gln Val Glu
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Tyr Ser Thr Asp Ser Thr Ala Asn Tyr
85 90 95
Lys Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu
100 105
<210> 2002
<211> 108
<212> PRT
<213> Homo sapiens
<400> 2002
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
1 5 10 15
Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Arg Arg Tyr Ala
20 25 30
Tyr Trp Tyr Gln Gln Arg Ser Gly Gln Ala Pro Val Leu Val Ile Tyr
35 40 45
Glu Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Ala Phe
50 55 60
Ser Ser Gly Thr Arg Ala Thr Leu Thr Ile Ser Gly Ala Gln Val Glu
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Tyr Ser Thr Asp Ser Thr Ala Asn Tyr
85 90 95
Lys Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 2003
<211> 108
<212> PRT
<213> Homo sapiens
<400> 2003
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
1 5 10 15
Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Arg Arg Tyr Ala
20 25 30
Tyr Trp Tyr Gln Gln Arg Ser Gly Gln Ala Pro Val Leu Val Ile Tyr
35 40 45
Glu Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Ala Phe
50 55 60
Ser Ser Gly Thr Arg Ala Thr Leu Thr Ile Ser Gly Ala Gln Val Glu
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Tyr Ser Thr Asp Ser Thr Ala Asn Tyr
85 90 95
Lys Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 2004
<211> 115
<212> PRT
<213> Homo sapiens
<400> 2004
Gln Ser Val Leu Thr Gln Pro Ser Ser Leu Ser Ala Ser Pro Gly Ala
1 5 10 15
Ser Ala Ser Leu Thr Cys Thr Leu His Ser Gly Phe Asn Val Gly Asp
20 25 30
His Thr Ile Asn Trp Tyr Gln Gln Arg Pro Gly Ser Pro Pro Arg Tyr
35 40 45
Leu Leu Lys Tyr Lys Ser Asp Ser Asp Lys Glu Gln Gly Ser Gly Val
50 55 60
Pro Ile Arg Phe Ser Gly Ser Lys Asp Ala Ser Ala Asn Ala Gly Phe
65 70 75 80
Leu Leu Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys
85 90 95
Met Ile Trp His Asp Asn Ala Val Val Phe Gly Gly Gly Thr Lys Leu
100 105 110
Thr Val Leu
115
<210> 2005
<211> 108
<212> PRT
<213> Homo sapiens
<400> 2005
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
1 5 10 15
Asp Gly Ala Ser Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Ser Asn
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Ser Asp Ala Ser Ala Arg Ala Thr Gly Val Pro Ala Arg Phe Thr Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Tyr Asn Thr Trp Pro Pro
85 90 95
Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 2006
<211> 112
<212> PRT
<213> Homo sapiens
<400> 2006
Glu Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly
1 5 10 15
Gln Ser Ala Ser Ile Ser Cys Arg Ser Ser Gln Gly Leu Val His Ser
20 25 30
Asp Gly Asn Ile Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser
35 40 45
Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Leu Tyr Tyr Cys Met Gln Ala
85 90 95
Thr His Trp Pro Arg Ala Phe Gly Gln Gly Thr Lys Val Asp Ile Lys
100 105 110
<210> 2007
<211> 112
<212> PRT
<213> Homo sapiens
<400> 2007
Asp Ile Val Met Thr Gln Ser Pro Leu Ala Leu Ser Val Thr Pro Gly
1 5 10 15
Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu His Ser
20 25 30
Asp Gly Lys Thr Tyr Phe Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro His Leu Leu Ile Tyr Glu Val Ser Asn Arg Phe Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ser
85 90 95
Ile Gln Val Pro Ile Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 2008
<211> 107
<212> PRT
<213> Homo sapiens
<400> 2008
Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Gly Ala Ser Thr Arg Ala Thr Asn Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Leu Trp Pro Tyr
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys
100 105
<210> 2009
<211> 107
<212> PRT
<213> Homo sapiens
<400> 2009
Glu Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Gly Ile Ser Thr Phe
20 25 30
Leu Ala Trp Phe Gln Gln Arg Pro Gly Lys Ala Pro Lys Ser Leu Ile
35 40 45
Tyr Ala Ala Ser Lys Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Asp Ser Gly Pro Asp Phe Thr Leu Thr Ile Asp Asn Leu Gln Pro
65 70 75 80
Glu Asp Ser Ala Thr Tyr Tyr Cys Lys Gln Tyr Asn Ser Tyr Pro Tyr
85 90 95
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 2010
<211> 110
<212> PRT
<213> Homo sapiens
<400> 2010
Gln Ser Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln
1 5 10 15
Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn
20 25 30
Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Asp Ser Asp Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser
50 55 60
Gly Ser Lys Ser Ala Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln
65 70 75 80
Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Glu Thr Trp Asp Asp Ser Leu
85 90 95
Ser Ala Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 2011
<211> 112
<212> PRT
<213> Homo sapiens
<400> 2011
Asp Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Ser Val Thr Pro Gly
1 5 10 15
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Gln His Thr
20 25 30
Asp Gly Lys Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Gln Leu Leu Ile Tyr Glu Leu Phe Asn Arg Phe Ser Gly Val Pro
50 55 60
Glu Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Met Gln Ser
85 90 95
Ile Gln Thr Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys
100 105 110
<210> 2012
<211> 113
<212> PRT
<213> Homo sapiens
<400> 2012
Asp Ile Arg Val Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser
20 25 30
Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Ile Gly Gln
35 40 45
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ile Arg Glu Ser Gly Val
50 55 60
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln
85 90 95
Tyr Tyr Ser Thr Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile
100 105 110
Lys
<210> 2013
<211> 112
<212> PRT
<213> Homo sapiens
<400> 2013
Glu Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Leu Gly
1 5 10 15
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Phe Val Ser His Thr
20 25 30
Asp Gly Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser
35 40 45
Pro Arg Arg Leu Ile Tyr Lys Val Ser Lys Arg Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala
85 90 95
Thr Glu Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Tyr Gln
100 105 110
<210> 2014
<211> 114
<212> PRT
<213> Homo sapiens
<400> 2014
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Phe Ser
20 25 30
Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Leu
35 40 45
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Lys Ser Gly Val
50 55 60
Ser Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln
85 90 95
Tyr Tyr Thr Thr Pro Leu Phe Thr Phe Gly Pro Gly Thr Lys Val Asp
100 105 110
Ile Lys
<210> 2015
<211> 112
<212> PRT
<213> Homo sapiens
<400> 2015
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly
1 5 10 15
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser His Ser Leu Val His Thr
20 25 30
Asn Gly Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Pro
35 40 45
Pro Arg Arg Leu Ile Tyr Gln Val Ser Asn Arg Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Asp Asp Val Gly Ile Tyr Tyr Cys Met Gln Gly
85 90 95
Thr Asp Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys
100 105 110
<210> 2016
<211> 112
<212> PRT
<213> Homo sapiens
<400> 2016
Glu Thr Thr Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly
1 5 10 15
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Gly Leu Ala His Ser
20 25 30
Asn Gly Asn Thr Tyr Leu Asn Trp Phe His Gln Arg Pro Gly Gln Ser
35 40 45
Pro Arg Arg Leu Ile Tyr Gln Val Ser Asn Arg Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly
85 90 95
Thr Glu Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105 110
<210> 2017
<211> 112
<212> PRT
<213> Homo sapiens
<400> 2017
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Ser Leu Gly
1 5 10 15
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Val Val His Thr
20 25 30
Asp Gly Asn Thr Tyr Leu Asn Trp Tyr Gln Gln Arg Pro Gly Gln Ser
35 40 45
Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Val Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Ala Val Tyr Tyr Cys Met Gln Gly
85 90 95
Thr Glu Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys
100 105 110
<210> 2018
<211> 113
<212> PRT
<213> Homo sapiens
<400> 2018
Asp Ile Gln Met Thr Gln Ser Pro Leu Ser Leu Ser Val Thr Leu Gly
1 5 10 15
Gln Ser Ala Ser Ile Ser Cys Arg Ala Ser Gln Thr Val Val His Ser
20 25 30
Val Asp Gly Asn Thr Tyr Leu Asn Trp Phe His Gln Arg Pro Gly Gln
35 40 45
Ser Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val
50 55 60
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg
65 70 75 80
Ile Ser Arg Val Glu Ala Glu Asp Ile Gly Ile Tyr Tyr Cys Met Gln
85 90 95
Gly Thr Asp Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile
100 105 110
Lys
<210> 2019
<211> 111
<212> PRT
<213> Homo sapiens
<400> 2019
Gln Pro Val Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Phe
20 25 30
Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Val Ile Tyr Asp Val Tyr Asn Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser
85 90 95
Ser Thr Leu Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 2020
<211> 106
<212> PRT
<213> Homo sapiens
<400> 2020
Asp Ile Arg Leu Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile
35 40 45
Tyr Lys Ala Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Gly Trp Thr
85 90 95
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 2021
<211> 112
<212> PRT
<213> Homo sapiens
<400> 2021
Asp Ile Arg Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly
1 5 10 15
Gln Pro Ala Ser Ile Ser Cys Thr Ser Ser Gln Asp Val Val His Thr
20 25 30
Asp Gly Asn Thr Tyr Leu Asn Trp Phe His Gln Arg Pro Gly Gln Ser
35 40 45
Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Ser His Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Ala Gly Ile Tyr Tyr Cys Met Gln Gly
85 90 95
Thr Asp Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys
100 105 110
<210> 2022
<211> 106
<212> PRT
<213> Homo sapiens
<400> 2022
Glu Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Leu Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Leu His Asn Tyr Ser Ser
85 90 95
Phe Gly Gly Gly Thr Lys Val Asp Ile Lys
100 105
<210> 2023
<211> 106
<212> PRT
<213> Homo sapiens
<400> 2023
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Phe
20 25 30
Leu Gly Trp Tyr Gln Gln Arg Pro Gly Gln Pro Pro Arg Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Tyr Arg Ala Pro Asp Ile Pro Val Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Pro
65 70 75 80
Glu Asp Ser Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asp Gly Tyr Asn
85 90 95
Phe Gly Pro Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 2024
<211> 109
<212> PRT
<213> Homo sapiens
<400> 2024
Gln Ser Val Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ala Tyr
20 25 30
Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Thr Val Tyr Asp Val Arg Asn Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala His Tyr Tyr Cys Ser Ser Tyr Thr Ser Thr
85 90 95
Asn Thr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 2025
<211> 112
<212> PRT
<213> Homo sapiens
<400> 2025
Asp Ile Arg Leu Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Leu Gly
1 5 10 15
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ile Ala Met His Ser
20 25 30
Asp Gly Asn Thr Tyr Leu Ser Trp Phe His Gln Arg Pro Gly Gln Pro
35 40 45
Pro Arg Arg Leu Ile Tyr Lys Ile Ser Asn Arg Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Ile Gly Thr Phe Tyr Cys Met Gln Gly
85 90 95
Thr Asp Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys
100 105 110
<210> 2026
<211> 110
<212> PRT
<213> Homo sapiens
<400> 2026
Gln Ser Ala Leu Ile Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Thr Phe Gly Thr Asp
20 25 30
Asn His Ile Ser Trp Tyr Gln Gln Leu Pro Gly Lys Val Pro Lys Leu
35 40 45
Ile Ile His Ala Val Ser Gln Arg Pro Ser Val Val Pro Asp Arg Phe
50 55 60
Ser Gly Ser Arg Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Ser Pro Gly Thr
85 90 95
Ile Thr Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 2027
<211> 107
<212> PRT
<213> Homo sapiens
<400> 2027
Asp Ile Arg Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Ala Cys Arg Ala Ser Gln Ser Val Ser Asn Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Asn Gly Val Pro Ser Arg Phe Gly Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Cys Tyr Ser Tyr Pro Pro
85 90 95
Thr Phe Gly His Gly Thr Lys Val Glu Ile Lys
100 105
<210> 2028
<211> 113
<212> PRT
<213> Homo sapiens
<400> 2028
Asp Ile Arg Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Glu Arg Ala Thr Ile Asn Cys Arg Thr Ser Gln Ser Val Leu Tyr Ser
20 25 30
Ser Asn Asn Lys Asn Tyr Leu Gly Trp Tyr Gln Gln Lys Pro Gly Gln
35 40 45
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln
85 90 95
Tyr Tyr Ser Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Asp Ile
100 105 110
Lys
<210> 2029
<211> 111
<212> PRT
<213> Homo sapiens
<400> 2029
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Asn Ser Asp Ile Ser Asn Ser
20 25 30
Tyr Ser Val Ser Trp Tyr Gln Gln Tyr Pro Gly Lys Ala Pro Lys Leu
35 40 45
Val Ile Phe Asp Val Ile Asn Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Thr Arg Thr
85 90 95
Asn Thr Pro Val Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 2030
<211> 108
<212> PRT
<213> Homo sapiens
<400> 2030
Asp Ile Gln Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Thr Lys His
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Gly Ala Ser Thr Arg Ala Thr Gly Val Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Asp Thr Glu Phe Ser Leu Thr Ile Ser Ser Leu Gln Ser
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Ser Trp Pro Pro
85 90 95
Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 2031
<211> 112
<212> PRT
<213> Homo sapiens
<400> 2031
Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Leu Gly
1 5 10 15
Gln Pro Ala Ser Ile Ser Cys Arg Ala Ser Gln Thr Val Val His Thr
20 25 30
Asn Gly Asn Thr Tyr Leu Asn Trp Phe His Gln Arg Pro Gly Gln Ser
35 40 45
Pro Arg Arg Leu Ile Tyr Glu Val Ser Asn Arg Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Ile Gly Val Tyr Tyr Cys Met Gln Gly
85 90 95
Thr Asp Trp Pro Arg Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys
100 105 110
<210> 2032
<211> 112
<212> PRT
<213> Homo sapiens
<400> 2032
Asp Ile Gln Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Gly Leu Gly
1 5 10 15
Gln Ser Ala Ser Ile Ser Cys Arg Ser Ser Gln Arg Val Val His Thr
20 25 30
Asp Gly Asn Thr Tyr Leu Asn Trp Tyr His Gln Arg Pro Gly Gln Ser
35 40 45
Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ser
85 90 95
Thr Asp Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 2033
<211> 112
<212> PRT
<213> Homo sapiens
<400> 2033
Asp Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Gly Leu Gly
1 5 10 15
Gln Ser Ala Ser Ile Ser Cys Arg Ser Ser Gln Arg Val Val His Thr
20 25 30
Asp Gly Asn Thr Tyr Leu His Trp Phe His Gln Arg Pro Gly Gln Ser
35 40 45
Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly
85 90 95
Thr Glu Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 2034
<211> 108
<212> PRT
<213> Homo sapiens
<400> 2034
Glu Thr Thr Leu Thr Gln Ser Pro Val Thr Leu Ser Val Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ile Ser Asn
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Phe Gly Ala Ser Thr Arg Ala Thr Gly Val Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Ser
85 90 95
Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 2035
<211> 112
<212> PRT
<213> Homo sapiens
<400> 2035
Asp Ile Gln Val Thr Gln Ser Pro Leu Ser Leu Pro Val Gly Leu Gly
1 5 10 15
Gln Ser Ala Ser Ile Ser Cys Arg Ser Ser Gln Arg Val Val His Thr
20 25 30
Asp Gly Asn Thr Tyr Leu Asn Trp Phe His Gln Arg Pro Gly Gln Ser
35 40 45
Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala
85 90 95
Thr Glu Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys
100 105 110
<210> 2036
<211> 106
<212> PRT
<213> Homo sapiens
<400> 2036
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Phe
20 25 30
Leu Gly Trp Tyr Gln Gln Arg Pro Gly Gln Pro Pro Arg Leu Leu Ile
35 40 45
Tyr Asp Ala Ser Tyr Arg Ala Pro Asp Ile Pro Val Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Pro
65 70 75 80
Glu Asp Ser Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asp Gly Tyr Asn
85 90 95
Phe Gly Pro Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 2037
<211> 108
<212> PRT
<213> Homo sapiens
<400> 2037
Gln Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
1 5 10 15
Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Arg Arg Tyr Ala
20 25 30
Tyr Trp Tyr Gln Gln Arg Ser Gly Gln Ala Pro Val Leu Val Ile Tyr
35 40 45
Glu Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Ala Phe
50 55 60
Ser Ser Gly Thr Arg Ala Thr Leu Thr Ile Ser Gly Ala Gln Val Glu
65 70 75 80
Asp Gln Ala Asp Tyr Tyr Cys Tyr Ser Thr Asp Ser Thr Ala Asn Tyr
85 90 95
Lys Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 2038
<211> 113
<212> PRT
<213> Mus musculus
<400> 2038
Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly
1 5 10 15
Glu Lys Ile Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Thr
20 25 30
Ser Asp Gln Lys Asn Tyr Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln
35 40 45
Ser Pro Lys Leu Leu Ile Phe Trp Ala Ser Thr Arg Asp Ser Gly Val
50 55 60
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln
85 90 95
Phe Tyr Asn Tyr Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile
100 105 110
Lys
<210> 2039
<211> 107
<212> PRT
<213> Mus musculus
<400> 2039
Ile Val Met Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Ala Gly Asp
1 5 10 15
Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asn Asp Val
20 25 30
Ala Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys Lys Leu Leu Ile
35 40 45
Tyr Phe Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly
50 55 60
Ser Gly Tyr Gly Thr Asp Phe Thr Phe Thr Ile Thr Thr Val Gln Ala
65 70 75 80
Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Pro Trp
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 2040
<211> 106
<212> PRT
<213> Mus musculus
<400> 2040
Ile Val Met Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Ala Gly Asp
1 5 10 15
Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asn Asp Val
20 25 30
Ala Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr
35 40 45
Phe Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly Ser
50 55 60
Gly Tyr Gly Thr Asp Phe Thr Phe Thr Ile Thr Thr Val Gln Ala Glu
65 70 75 80
Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Pro Trp Thr
85 90 95
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 2041
<211> 113
<212> PRT
<213> Mus musculus
<400> 2041
Asp Ile Val Met Thr Gln Ala Ala Pro Ser Glu Pro Val Thr Pro Gly
1 5 10 15
Glu Ser Val Ser Ile Ser Cys Gly Ser Ser Lys Ser Leu Leu His Ser
20 25 30
Asn Asp Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser
35 40 45
Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro
50 55 60
Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His
85 90 95
Leu Glu Asn Pro Leu Gly Val Arg Trp Arg His Gln Ala Gly Asn Gln
100 105 110
Thr
<210> 2042
<211> 108
<212> PRT
<213> Mus musculus
<400> 2042
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly
1 5 10 15
Glu Arg Val Thr Met Thr Cys Thr Ala Ser Ser Ser Val Ser Ser Ser
20 25 30
Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp
35 40 45
Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu
65 70 75 80
Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Leu Gln Tyr His Arg Ser Pro
85 90 95
Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 2043
<211> 109
<212> PRT
<213> Homo sapiens
<400> 2043
Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly
1 5 10 15
Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Pro Val Thr Ser Asp
20 25 30
His Tyr Pro Tyr Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Thr Thr
35 40 45
Leu Ile Tyr Asp Thr Asn Asn Lys His Ser Trp Thr Pro Ala Arg Phe
50 55 60
Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Ala
65 70 75 80
Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Leu Leu Ser Tyr Thr Gly
85 90 95
Ala Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 2044
<211> 107
<212> PRT
<213> Homo sapiens
<400> 2044
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Gly
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 2045
<211> 107
<212> PRT
<213> Homo sapiens
<400> 2045
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Gly
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 2046
<211> 107
<212> PRT
<213> Homo sapiens
<400> 2046
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Ser Ser Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Pro Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Leu Tyr
85 90 95
Ser Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 2047
<211> 107
<212> PRT
<213> Homo sapiens
<400> 2047
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp
20 25 30
Leu Gly Trp Tyr Glu Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Thr Tyr Pro Phe
85 90 95
Thr Phe Gly Pro Gly Thr Arg Val Asp Ile Lys
100 105
<210> 2048
<211> 108
<212> PRT
<213> Homo sapiens
<400> 2048
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser
20 25 30
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
35 40 45
Ile Tyr Gly Val Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65 70 75 80
Pro Glu Asp Phe Val Val Tyr Tyr Cys His Gln Tyr Gly Ser Ser Pro
85 90 95
Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 2049
<211> 106
<212> PRT
<213> Homo sapiens
<400> 2049
Asp Ile Gln Met Ile Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Thr Leu Leu Ser Ala Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Ser Phe Pro Phe
85 90 95
Thr Phe Gly Pro Gly Thr Ile Val Asp Val
100 105
<210> 2050
<211> 107
<212> PRT
<213> Homo sapiens
<400> 2050
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp
20 25 30
Leu Gly Trp Tyr Glu Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Thr Tyr Pro Phe
85 90 95
Thr Phe Gly Pro Gly Thr Arg Val Asp Ile Lys
100 105
<210> 2051
<211> 106
<212> PRT
<213> Homo sapiens
<400> 2051
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ala Ser Thr Leu Leu Ser Ala Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Ser Phe Pro Phe
85 90 95
Thr Phe Gly Pro Gly Thr Lys Val Asp Val
100 105
<210> 2052
<211> 107
<212> PRT
<213> Homo sapiens
<400> 2052
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp
20 25 30
Leu Gly Trp Tyr Glu Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Thr Tyr Pro Phe
85 90 95
Thr Phe Gly Pro Gly Thr Arg Val Asp Ile Lys
100 105
<210> 2053
<211> 108
<212> PRT
<213> Homo sapiens
<400> 2053
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser His Ser Val Asp Arg Ser
20 25 30
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Leu Ala Pro Arg Leu Leu
35 40 45
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65 70 75 80
Pro Glu Asp Phe Ala Leu Tyr Tyr Cys Gln His Phe Gly Thr Ser Ser
85 90 95
Val Thr Phe Gly Arg Gly Thr Arg Leu Glu Ile Lys
100 105
<210> 2054
<211> 108
<212> PRT
<213> Homo sapiens
<400> 2054
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser
20 25 30
Tyr Leu Ala Trp Tyr Gln His Lys Pro Gly Gln Ala Pro Arg Leu Leu
35 40 45
Ile Cys Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Arg Leu Glu
65 70 75 80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro
85 90 95
Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 2055
<211> 110
<212> PRT
<213> Homo sapiens
<400> 2055
Gln Ser Ala Leu Thr Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr
20 25 30
Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Met Ile Tyr Glu Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ala Gly Ser
85 90 95
Asn Asn Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 2056
<211> 107
<212> PRT
<213> Homo sapiens
<400> 2056
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Val Ser Ser Thr
20 25 30
Ser Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
35 40 45
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65 70 75 80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln His Asp Thr Ser Leu
85 90 95
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 2057
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2057
Ala Arg Arg Gly Asp Gly Leu Tyr Tyr Tyr Gly Met Asp Val
1 5 10
<210> 2058
<211> 18
<212> PRT
<213> Homo sapiens
<400> 2058
Ala Arg Asp Arg Ile Ala Pro Val Gly Lys Phe Phe Gly Trp Tyr Phe
1 5 10 15
Asp Leu
<210> 2059
<211> 10
<212> PRT
<213> Homo sapiens
<400> 2059
Ala Arg Ser Ser Ser Arg Gly Phe Asp Tyr
1 5 10
<210> 2060
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2060
Ala Arg Glu Leu Phe Thr Ala Val Ala Gly Lys Gly Gly Ile Asp Tyr
1 5 10 15
<210> 2061
<211> 22
<212> PRT
<213> Homo sapiens
<400> 2061
Ala Lys Asp Phe Lys Gly Gly Ser Ser Ser Trp Tyr Thr Pro Glu Ile
1 5 10 15
Glu Tyr Gly Met Asp Val
20
<210> 2062
<211> 28
<212> PRT
<213> Homo sapiens
<400> 2062
Ala Arg Leu Ile Arg His Glu Ala His Thr Tyr Cys Ser Gly Gly Ser
1 5 10 15
Cys Tyr Ser Pro Asp Tyr Tyr Tyr Gly Met Asp Val
20 25
<210> 2063
<211> 13
<212> PRT
<213> Homo sapiens
<400> 2063
Ala Ser Asn Pro Pro Leu Gly Glu Pro Tyr Phe Asp Ile
1 5 10
<210> 2064
<211> 12
<212> PRT
<213> Homo sapiens
<400> 2064
Ala Arg Trp Gly Gly Gly Met Gln Tyr Leu Asp Val
1 5 10
<210> 2065
<211> 19
<212> PRT
<213> Homo sapiens
<400> 2065
Ala Arg Ala Gly Pro Asn Tyr Asp Phe Trp Ser Gly Tyr Tyr Gln Thr
1 5 10 15
Phe Asp Tyr
<210> 2066
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2066
Ala Thr Ala Thr Ala Met Asp Gly Tyr Tyr Tyr Tyr Tyr Gly Met Asp
1 5 10 15
Val
<210> 2067
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2067
Ala Ser Ala Gly Ser Ser Trp Tyr Gly Asp Ala Phe Asp Ile
1 5 10
<210> 2068
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2068
Ala Thr Ala Thr Ile Phe Gly Val Ala Asn Asn Trp Phe Asp Pro
1 5 10 15
<210> 2069
<211> 25
<212> PRT
<213> Homo sapiens
<400> 2069
Ala Lys Asp Leu Gly Tyr Tyr Asp Ile Leu Thr Gly Gln Leu Gly Gly
1 5 10 15
Tyr Tyr Tyr Tyr Tyr Gly Met Asp Val
20 25
<210> 2070
<211> 19
<212> PRT
<213> Homo sapiens
<400> 2070
Ala Arg Asp Trp Asp Tyr Asp Ile Leu Thr Gly Ser Trp Phe Gly Ala
1 5 10 15
Phe Asp Ile
<210> 2071
<211> 15
<212> PRT
<213> Mus musculus
<400> 2071
Ala Arg Lys Asp Tyr Tyr Tyr Gly Ser Ser Tyr Ala Met Asp Tyr
1 5 10 15
<210> 2072
<211> 14
<212> PRT
<213> Mus musculus
<400> 2072
Ala Arg Asp Tyr Gly Ser Ser Tyr Val Asp Tyr Phe Asp Tyr
1 5 10
<210> 2073
<211> 14
<212> PRT
<213> Mus musculus
<400> 2073
Ser Thr Gly Gly Tyr Gly Asn Tyr Val Asp Ala Met Asp Tyr
1 5 10
<210> 2074
<211> 15
<212> PRT
<213> Mus musculus
<400> 2074
Ala Arg Lys Asp Tyr Tyr Gly Ser Ser Ser Asn Val Met Asp Tyr
1 5 10 15
<210> 2075
<211> 14
<212> PRT
<213> Mus musculus
<400> 2075
Ala Arg Lys Asp Tyr Tyr Gly Ser Ser Leu Ala Met Asp Tyr
1 5 10
<210> 2076
<211> 14
<212> PRT
<213> Mus musculus
<400> 2076
Ala Arg Arg Asn Tyr Asp Leu Tyr Tyr Tyr Ala Met Asp Tyr
1 5 10
<210> 2077
<211> 17
<212> PRT
<213> Mus musculus
<400> 2077
Ala Arg Ser Asp Tyr Tyr Gly Ser Ser Tyr Val Gly Tyr Ala Met Asp
1 5 10 15
Tyr
<210> 2078
<211> 14
<212> PRT
<213> Mus musculus
<400> 2078
Ala Arg Arg Asn Tyr Asp Leu Tyr Tyr Tyr Ala Met Asp Tyr
1 5 10
<210> 2079
<211> 14
<212> PRT
<213> Mus musculus
<400> 2079
Ser Thr Gly Gly Tyr Gly Asn Tyr Val Asp Ala Met Asp Tyr
1 5 10
<210> 2080
<211> 15
<212> PRT
<213> Mus musculus
<400> 2080
Ala Arg Lys Asp Tyr Tyr Gly Ser Ser Ser Asn Val Met Asp Tyr
1 5 10 15
<210> 2081
<211> 14
<212> PRT
<213> Mus musculus
<400> 2081
Ser Arg Arg Asn Tyr Asp Leu Tyr Tyr Tyr Ala Met Asp Tyr
1 5 10
<210> 2082
<211> 7
<212> PRT
<213> Mus musculus
<400> 2082
Ala Arg Gly Ala Gly Ala Tyr
1 5
<210> 2083
<211> 7
<212> PRT
<213> Mus musculus
<400> 2083
Ala Arg Asp His Gly Pro Ala
1 5
<210> 2084
<211> 7
<212> PRT
<213> Mus musculus
<400> 2084
Ala Arg Gly Ala Gly Ala Tyr
1 5
<210> 2085
<211> 13
<212> PRT
<213> Mus musculus
<400> 2085
Ala Arg Ile Ser Tyr Tyr Asp Tyr Glu Gly Val Asp Tyr
1 5 10
<210> 2086
<211> 20
<212> PRT
<213> Homo sapiens
<400> 2086
Ala Arg Gly Ala Glu Tyr Tyr Asp Phe Trp Ser Gly Tyr Tyr Ser Ala
1 5 10 15
Tyr Phe Asp Tyr
20
<210> 2087
<211> 14
<212> PRT
<213> Mus musculus
<400> 2087
Ala Arg Lys Asp Tyr Tyr Gly Arg Tyr Tyr Gly Met Asp Tyr
1 5 10
<210> 2088
<211> 11
<212> PRT
<213> Mus musculus
<400> 2088
Ala Ile Leu Asp Ser Tyr Trp Tyr Phe Asp Val
1 5 10
<210> 2089
<211> 12
<212> PRT
<213> Mus musculus
<400> 2089
Ala Arg Lys Ser Tyr Gly Tyr Trp His Phe Asp Val
1 5 10
<210> 2090
<211> 7
<212> PRT
<213> Mus musculus
<400> 2090
Ala Ala Gly Lys Gly Asp Tyr
1 5
<210> 2091
<211> 11
<212> PRT
<213> Mus musculus
<400> 2091
Ala Ile Leu Asp Ser Tyr Trp Tyr Phe Asp Val
1 5 10
<210> 2092
<211> 7
<212> PRT
<213> Mus musculus
<400> 2092
Ala Ala Gly Lys Gly Asp Tyr
1 5
<210> 2093
<211> 13
<212> PRT
<213> Mus musculus
<400> 2093
Ala Arg Lys Gly Asp Gly Tyr Tyr Gly Gly Phe Ala Tyr
1 5 10
<210> 2094
<211> 15
<212> PRT
<213> Mus musculus
<400> 2094
Ala Thr Tyr Gly Ser Tyr Tyr Leu Tyr Tyr Tyr Ala Met Asn Tyr
1 5 10 15
<210> 2095
<211> 14
<212> PRT
<213> Mus musculus
<400> 2095
Ala Arg Tyr Asp Gly Asn Leu Tyr Tyr Tyr Ala Met Asp Tyr
1 5 10
<210> 2096
<211> 13
<212> PRT
<213> Mus musculus
<400> 2096
Ala Arg Trp Asp Phe Tyr Gly Ser Arg Thr Phe Asp Tyr
1 5 10
<210> 2097
<211> 13
<212> PRT
<213> Mus musculus
<400> 2097
Ala Arg Trp Asp Phe Tyr Gly Ser Arg Thr Phe Asp Tyr
1 5 10
<210> 2098
<211> 13
<212> PRT
<213> Homo sapiens
<400> 2098
Ala Arg Ala Thr Trp Leu Arg Gly Val Met Asp Val Trp
1 5 10
<210> 2099
<211> 19
<212> PRT
<213> Homo sapiens
<400> 2099
Ala Lys Asp Val Arg Tyr Cys Ser Ser Thr Ser Cys Tyr Phe Ser Ala
1 5 10 15
Phe Asp Ile
<210> 2100
<211> 13
<212> PRT
<213> Homo sapiens
<400> 2100
Ala Arg Gly Gly Gly Ser Tyr Tyr Tyr Trp Phe Asp Pro
1 5 10
<210> 2101
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2101
Ala Arg Ala Gly Tyr Ser Ser Ser Trp Tyr Gly Val Arg Gly Val Asp
1 5 10 15
Pro
<210> 2102
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2102
Ala Lys Gly Ser Asp Ile Val Val Val Pro Val Gly Asn Trp Phe Asp
1 5 10 15
Pro
<210> 2103
<211> 20
<212> PRT
<213> Homo sapiens
<400> 2103
Ala Arg Val Gln Arg Tyr Tyr Pro Asp Ser Ser Gly Phe Tyr Gly Arg
1 5 10 15
Arg Phe Asp Ile
20
<210> 2104
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2104
Ala Arg Ser Gly Gly Gly Ser Tyr Arg Gly Pro Phe Asp Tyr
1 5 10
<210> 2105
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2105
Ala Arg Gly Asp Arg Ile Gln Leu Trp Leu Leu Asp Ala Phe Asp Ile
1 5 10 15
<210> 2106
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2106
Ala Lys Ile Gly Leu Gly Leu Gly Gly Leu Leu Arg Arg Tyr Phe Asp
1 5 10 15
Tyr
<210> 2107
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2107
Gly Thr Arg Ile Met Ile Thr Trp Tyr Ser Arg Arg Gly Met Asp Gly
1 5 10 15
<210> 2108
<211> 25
<212> PRT
<213> Homo sapiens
<400> 2108
Ala Arg Glu Arg Gly Asp Ser Ser Gly Tyr Tyr Glu Ile Ile Thr Thr
1 5 10 15
Ala Asn Arg Arg Phe Gly Met Asp Val
20 25
<210> 2109
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2109
Ala Arg Ile Pro Gly Trp Asp Arg Gly Thr Asp Arg Asn Trp Asn Asp
1 5 10 15
Asp
<210> 2110
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2110
Ala Arg Thr Tyr Ser Phe Asp Ser Ser Gly Tyr Tyr Tyr Asp Tyr
1 5 10 15
<210> 2111
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2111
Ala Arg Ala Phe Tyr Asp Ser Asn Trp Ser Val Gly Ser Tyr Phe Asp
1 5 10 15
Ser
<210> 2112
<211> 18
<212> PRT
<213> Homo sapiens
<400> 2112
Ala Lys Asp Ser Val Arg Arg Glu Tyr Thr His Ala Arg Val Pro Phe
1 5 10 15
Asp Asn
<210> 2113
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2113
Ala Lys Ser Ser Lys Ile Phe Tyr Leu Gly Glu Ser Arg Glu Val Asp
1 5 10 15
Tyr
<210> 2114
<211> 19
<212> PRT
<213> Homo sapiens
<400> 2114
Ala Arg Val Glu Tyr Tyr Tyr Gly Ser Gly Ser Tyr Met Pro Trp Tyr
1 5 10 15
Phe Asp Leu
<210> 2115
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2115
Ala Thr Tyr Tyr Tyr Asp Ser Ser Gly Tyr Ser Tyr Gly Met Asp Val
1 5 10 15
<210> 2116
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2116
Thr Glu Glu Gly Ser Gly Ser Glu Gly Pro Ile Glu Phe Asp Tyr
1 5 10 15
<210> 2117
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2117
Ala Arg Asp Asn Asn Tyr Arg Asn Tyr Tyr Tyr Tyr Met Asp Val Trp
1 5 10 15
<210> 2118
<211> 20
<212> PRT
<213> Homo sapiens
<400> 2118
Ala Arg Gly Ala Leu Gly Cys Ser Ser Thr Ser Cys Tyr Pro Asn Asn
1 5 10 15
Phe Asp Tyr Trp
20
<210> 2119
<211> 2
<212> PRT
<213> Homo sapiens
<400> 2119
Asn Asp
1
<210> 2120
<211> 21
<212> PRT
<213> Homo sapiens
<400> 2120
Ala Thr Ser Thr Ala Val Ala Gly Thr Pro Asp Leu Phe Asp Tyr Tyr
1 5 10 15
Tyr Gly Met Asp Val
20
<210> 2121
<211> 13
<212> PRT
<213> Homo sapiens
<400> 2121
Ala Arg Asp Phe Ile Ser Arg Pro Arg Gly Tyr Arg Trp
1 5 10
<210> 2122
<211> 13
<212> PRT
<213> Homo sapiens
<400> 2122
Ala Arg Asp Phe Ile Ser Arg Pro Arg Gly Tyr Arg Trp
1 5 10
<210> 2123
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2123
Ala Arg Gly Gln Asp Asp Phe Trp Ser Met Asn Trp Phe Asp Pro Trp
1 5 10 15
<210> 2124
<211> 13
<212> PRT
<213> Homo sapiens
<400> 2124
Ala Arg Asp Phe Ile Ser Arg Pro Arg Gly Tyr Arg Trp
1 5 10
<210> 2125
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2125
Thr Arg Gly Ser Gln Trp Ala Thr Ile Asn Asp Ala Arg Phe Asp Tyr
1 5 10 15
Trp
<210> 2126
<211> 13
<212> PRT
<213> Homo sapiens
<400> 2126
Ala Arg Val Trp Tyr Tyr Tyr Gly Pro Arg Asp Tyr Trp
1 5 10
<210> 2127
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2127
Ala Lys Asp Ser Ser Ser Trp Tyr Asn Tyr Tyr Gly Met Asp Val Trp
1 5 10 15
<210> 2128
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2128
Ala Arg Val Phe Arg Gly Ser Gln Tyr Trp Phe Asp Pro Trp
1 5 10
<210> 2129
<211> 13
<212> PRT
<213> Homo sapiens
<400> 2129
Ala Arg Met Glu Ala Pro Lys Leu Thr Leu Asp Pro Trp
1 5 10
<210> 2130
<211> 19
<212> PRT
<213> Homo sapiens
<400> 2130
Ala Arg Asp Trp Asp Tyr Asp Ile Leu Thr Gly Ser Trp Phe Gly Ala
1 5 10 15
Phe Asp Ile
<210> 2131
<211> 13
<212> PRT
<213> Homo sapiens
<400> 2131
Ala Arg Pro Thr Ile Gly Tyr Ser Tyr Gly Ser Asp Tyr
1 5 10
<210> 2132
<211> 18
<212> PRT
<213> Homo sapiens
<400> 2132
Ala Lys Val Ser Ala Ile Phe Trp Leu Gly Gln Gly Leu Ser Pro Ile
1 5 10 15
Asp Val
<210> 2133
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2133
Ala Arg Val Gln Val Ala Ala Ala Gly Ser Pro Tyr Asp Tyr
1 5 10
<210> 2134
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2134
Ala Lys Asp Arg Gly Tyr Glu Ile Leu Thr Pro Ala Ser Phe Asp Tyr
1 5 10 15
<210> 2135
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2135
Ala Thr Gly Arg Tyr Thr Tyr Gly Tyr Gly Tyr Tyr Phe Asp Tyr
1 5 10 15
<210> 2136
<211> 13
<212> PRT
<213> Homo sapiens
<400> 2136
Ala Arg Asp Tyr Gly Gly Asn Ser Asn Tyr Phe His Tyr
1 5 10
<210> 2137
<211> 11
<212> PRT
<213> Homo sapiens
<400> 2137
Ala Arg Ile Gln Arg Gly Ile Ala Ala Asp Tyr
1 5 10
<210> 2138
<211> 11
<212> PRT
<213> Homo sapiens
<400> 2138
Ala Arg Asp Lys Trp Glu Gly Thr Phe Asp Tyr
1 5 10
<210> 2139
<211> 10
<212> PRT
<213> Homo sapiens
<400> 2139
Ala Glu Thr Gly Trp Asp Gly Met Asp Val
1 5 10
<210> 2140
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2140
Ala Arg His Cys Pro Trp Gln Gln Leu Val Ser Asn Trp Phe Asp Pro
1 5 10 15
<210> 2141
<211> 21
<212> PRT
<213> Homo sapiens
<400> 2141
Ala Arg Glu Lys Ile Arg Ser Ile Ala Ala Ala Gly Thr Val Tyr Tyr
1 5 10 15
Tyr Gly Met Asp Val
20
<210> 2142
<211> 21
<212> PRT
<213> Homo sapiens
<400> 2142
Ala Arg Ile Tyr Arg Gly Thr Met Val Val Val Phe Ser Asp Leu His
1 5 10 15
Trp Tyr Phe Asp Leu
20
<210> 2143
<211> 12
<212> PRT
<213> Homo sapiens
<400> 2143
Ala Gly Leu Phe Trp Tyr Gly Gly Tyr Phe Asp Tyr
1 5 10
<210> 2144
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2144
Ala Ser Thr Tyr Trp Asp Ser Ser Gly Tyr Tyr Tyr Gly Val Asp Tyr
1 5 10 15
<210> 2145
<211> 22
<212> PRT
<213> Homo sapiens
<400> 2145
Ala Val Leu Asp Tyr Cys Ser Gly Gly Ser Ser Ser Ser Gly Tyr Tyr
1 5 10 15
Asn Tyr Gly Met Asp Val
20
<210> 2146
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2146
Ala Arg Asp Ser Leu Phe Ser Arg Val Asp Trp Tyr Phe Asp Leu
1 5 10 15
<210> 2147
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2147
Ala Leu Ala Val Gly Arg Gly Ile Pro Thr Ser Tyr Phe Asp Tyr
1 5 10 15
<210> 2148
<211> 13
<212> PRT
<213> Homo sapiens
<400> 2148
Ala Arg Glu Gly Ala Gly Leu Ile Ile Ala Tyr Asp Tyr
1 5 10
<210> 2149
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2149
Ala Arg Asp Gly Ala Leu Tyr Ser Asn Ser Pro Thr Glu Phe Asp Tyr
1 5 10 15
<210> 2150
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2150
Ala Lys Gly Gly Asn Tyr Gly Asp Tyr Leu Arg Gly Phe Asp Tyr
1 5 10 15
<210> 2151
<211> 19
<212> PRT
<213> Homo sapiens
<400> 2151
Val Arg Gly Asp His Ser Ser Gly Trp Tyr Gly Thr Tyr Tyr Tyr Tyr
1 5 10 15
Met Asp Val
<210> 2152
<211> 24
<212> PRT
<213> Homo sapiens
<400> 2152
Ala Arg Gly Leu Gln Tyr Tyr Tyr Asp Thr Ser Gly Tyr Tyr Lys Asp
1 5 10 15
Ser Tyr Tyr Tyr Gly Val Asp Val
20
<210> 2153
<211> 12
<212> PRT
<213> Homo sapiens
<400> 2153
Ala Arg Asp Leu Asn Ile Ala Gly Gly Phe Asp Ile
1 5 10
<210> 2154
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2154
Ala Arg Asp Leu Ala Trp Phe Gly Glu Leu Ser Glu Ser Pro Ile Glu
1 5 10 15
Tyr
<210> 2155
<211> 23
<212> PRT
<213> Homo sapiens
<400> 2155
Ala His Arg Leu Ala Pro Asp Tyr Asp Phe Leu Thr Gly Tyr Tyr Asn
1 5 10 15
Gly Asp Asp Ala Phe Asp Val
20
<210> 2156
<211> 18
<212> PRT
<213> Homo sapiens
<400> 2156
Ala Arg Glu Gly Leu Leu Val Gly Pro Thr Gly Arg Gly Leu Gly Met
1 5 10 15
Asp Val
<210> 2157
<211> 12
<212> PRT
<213> Homo sapiens
<400> 2157
Ala Arg Met Val Val Arg Gly Val Met Leu Asp Tyr
1 5 10
<210> 2158
<211> 13
<212> PRT
<213> Homo sapiens
<400> 2158
Ala Thr Arg Thr Gly Trp Thr Asn Asp Ala Phe Asp Ile
1 5 10
<210> 2159
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2159
Ala Arg Ala Arg Gln Leu Val Leu Asn Trp Tyr Phe Asp Leu
1 5 10
<210> 2160
<211> 12
<212> PRT
<213> Homo sapiens
<400> 2160
Ala Arg Leu Met Tyr Tyr Tyr Gly Asn Phe Asp Tyr
1 5 10
<210> 2161
<211> 19
<212> PRT
<213> Homo sapiens
<400> 2161
Ala Arg Val Gly Tyr Tyr Gly Ser Gly Ser Tyr Pro Leu Tyr Trp Tyr
1 5 10 15
Phe Asp Leu
<210> 2162
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2162
Ala Thr Gly Arg Tyr Thr Tyr Gly Tyr Gly Tyr Tyr Phe Asp Tyr
1 5 10 15
<210> 2163
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2163
Ala Arg Leu Ala Ser Asp Gly Ser Gly Ser Tyr Leu Asp Tyr Phe Asp
1 5 10 15
Tyr
<210> 2164
<211> 20
<212> PRT
<213> Homo sapiens
<400> 2164
Ala Thr Asp Gly Gly Gly Gly Ser Tyr Tyr Tyr Ala His Tyr Tyr Tyr
1 5 10 15
Gly Met Asp Val
20
<210> 2165
<211> 18
<212> PRT
<213> Homo sapiens
<400> 2165
Ala Lys Asp Ile Gly Val Met Val Pro Gly Val Thr Pro Tyr Gly Met
1 5 10 15
Asp Val
<210> 2166
<211> 11
<212> PRT
<213> Homo sapiens
<400> 2166
Ala Arg Asp Pro Met Arg Pro Gly Met Asp Val
1 5 10
<210> 2167
<211> 13
<212> PRT
<213> Homo sapiens
<400> 2167
Ala Arg Glu Ser Pro Lys Leu Thr Gly Tyr Phe Asp Tyr
1 5 10
<210> 2168
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2168
Ala Arg Gly Arg Tyr Thr Tyr Gly Thr Glu Gly Tyr Phe Asp Asn
1 5 10 15
<210> 2169
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2169
Ala Arg Asp Ala Val Gly Ser Tyr Tyr Tyr Gly Met Glu Val
1 5 10
<210> 2170
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2170
Ala Arg Glu Gly Leu Val Gly Thr Thr Leu Thr Phe Asp Tyr
1 5 10
<210> 2171
<211> 13
<212> PRT
<213> Homo sapiens
<400> 2171
Ala Arg Tyr Tyr Gly Pro Gln Gly Arg Ala Phe Asp Ile
1 5 10
<210> 2172
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2172
Ala Arg Gly Thr Glu Tyr Gly Asp Tyr Asp Val Ser His Asp
1 5 10
<210> 2173
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2173
Ala Arg Glu Gly Leu Val Gly Thr Ala Leu Ala Phe Asp Tyr
1 5 10
<210> 2174
<211> 21
<212> PRT
<213> Homo sapiens
<400> 2174
Ala Lys Asp Pro Thr Ser Leu Tyr Cys Ser Gly Gly Ser Cys Tyr Asn
1 5 10 15
Asn Trp Phe Asp Pro
20
<210> 2175
<211> 11
<212> PRT
<213> Homo sapiens
<400> 2175
Ala Arg Asp Leu Asp Tyr Tyr Gly Met Asp Val
1 5 10
<210> 2176
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2176
Ala Gly Gly Gly Val Leu Val Thr Ser Asp Pro Asp Ala Phe Asp Ile
1 5 10 15
<210> 2177
<211> 13
<212> PRT
<213> Homo sapiens
<400> 2177
Ala Gly Glu Gln His Ile Val Thr Thr Ile Ile Asp Tyr
1 5 10
<210> 2178
<211> 11
<212> PRT
<213> Homo sapiens
<400> 2178
Ala Arg Asp Tyr Gly Asp Tyr Tyr Phe Asp Tyr
1 5 10
<210> 2179
<211> 11
<212> PRT
<213> Homo sapiens
<400> 2179
Ala Arg Gln Glu Ser Gly Trp Ser Phe Asp Tyr
1 5 10
<210> 2180
<211> 13
<212> PRT
<213> Homo sapiens
<400> 2180
Ala Lys Gly Gln Arg Gly Ser Pro Asp Phe Phe Asp Tyr
1 5 10
<210> 2181
<211> 9
<212> PRT
<213> Homo sapiens
<400> 2181
Ala Arg Ala Gly Trp Glu Leu Asn Tyr
1 5
<210> 2182
<211> 11
<212> PRT
<213> Homo sapiens
<400> 2182
Ala Arg Asp Leu Val Thr Trp Gly Leu Asp Tyr
1 5 10
<210> 2183
<211> 13
<212> PRT
<213> Homo sapiens
<400> 2183
Ser Thr Thr Asn Asp Tyr Gly Asp Tyr Ser Ala Asn Tyr
1 5 10
<210> 2184
<211> 19
<212> PRT
<213> Homo sapiens
<400> 2184
Ala Arg Gly Leu Trp Phe Gly Asp Leu Thr Arg Thr Lys Tyr Asn Trp
1 5 10 15
Phe Asp Pro
<210> 2185
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2185
Ala Arg Asp Asp Ser Ser Ser Ser Gly Val Gly Thr Gly Met Asp Val
1 5 10 15
<210> 2186
<211> 11
<212> PRT
<213> Homo sapiens
<400> 2186
Ala Arg Ile Thr Pro His Leu Val Tyr Asp Tyr
1 5 10
<210> 2187
<211> 23
<212> PRT
<213> Homo sapiens
<400> 2187
Ala Arg Thr Leu Gly Ala Tyr Tyr Asp Ile Leu Thr Gly Phe Arg Thr
1 5 10 15
Pro Gly Gly Trp Phe Ala Pro
20
<210> 2188
<211> 23
<212> PRT
<213> Homo sapiens
<400> 2188
Ala Ser Pro Leu Leu Ser His Asn Tyr Gly Ser Gly Ser Tyr Tyr Asn
1 5 10 15
Val Tyr Trp Tyr Phe Glu Leu
20
<210> 2189
<211> 11
<212> PRT
<213> Homo sapiens
<400> 2189
Ala Arg Asp Leu Glu Asn Gly Gly Leu Asp Val
1 5 10
<210> 2190
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2190
Ala Ala Pro Asn Cys Asn Ser Thr Thr Cys His Asp Gly Phe Asp Ile
1 5 10 15
<210> 2191
<211> 13
<212> PRT
<213> Homo sapiens
<400> 2191
Ala Arg Asp Leu Pro Leu His Gly Asp Tyr Phe Asp Tyr
1 5 10
<210> 2192
<211> 22
<212> PRT
<213> Homo sapiens
<400> 2192
Ala Arg His Arg Arg Asp Tyr Ile Thr Met Ile Val Arg Pro Thr Arg
1 5 10 15
Leu Trp Ala Phe Asp Tyr
20
<210> 2193
<211> 13
<212> PRT
<213> Homo sapiens
<400> 2193
Ala Arg Glu Ala Gly Thr Thr Asp Trp Tyr Phe Asp Leu
1 5 10
<210> 2194
<211> 18
<212> PRT
<213> Homo sapiens
<400> 2194
Ala Arg His Pro Arg Phe Ser Trp Arg Gly Asn Asp Ser Gly Tyr Phe
1 5 10 15
Asp Tyr
<210> 2195
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2195
Ala His Ser Met Val Arg Gly Val Leu Phe Gly Ala Asp Phe Asp Tyr
1 5 10 15
<210> 2196
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2196
Ala Arg Asp Gly Val Asp Phe Gly Met Val Thr Leu Phe Asp Tyr
1 5 10 15
<210> 2197
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2197
Ala Ile Thr Ser Val Ala Arg Gly Leu Arg Gly Tyr Phe Asp Thr
1 5 10 15
<210> 2198
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2198
Ala Ile Thr Ser Leu Ala Arg Gly Leu Lys Gly Tyr Phe Asp Ser
1 5 10 15
<210> 2199
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2199
Ala Arg Gly Trp Thr Val Pro Pro Leu Trp Val Leu Asn Trp Phe Asp
1 5 10 15
Pro
<210> 2200
<211> 18
<212> PRT
<213> Homo sapiens
<400> 2200
Ala Met Thr Tyr Tyr Asp Tyr Ile Trp Gly Arg Val Asp Pro Gln Phe
1 5 10 15
Asp Pro
<210> 2201
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2201
Ala Arg Phe Ile Thr Asp Gly Tyr Ser Ser Gly Ser Asp Ser
1 5 10
<210> 2202
<211> 20
<212> PRT
<213> Homo sapiens
<400> 2202
Ala Lys Gln Ala Ser Pro Tyr Cys Ser Gly Gly Ser Cys Tyr Ser Gly
1 5 10 15
Asn Phe Asp Tyr
20
<210> 2203
<211> 9
<212> PRT
<213> Homo sapiens
<400> 2203
Ala Arg Glu Ala Tyr Gly Met Asp Val
1 5
<210> 2204
<211> 12
<212> PRT
<213> Homo sapiens
<400> 2204
Ala Arg Asp Leu Gly Glu Ala Gly Gly Met Asp Val
1 5 10
<210> 2205
<211> 11
<212> PRT
<213> Homo sapiens
<400> 2205
Ala Arg Asp Leu Val Val Tyr Gly Met Asp Val
1 5 10
<210> 2206
<211> 11
<212> PRT
<213> Homo sapiens
<400> 2206
Ala Arg Asp Leu Val Val Tyr Gly Met Asp Val
1 5 10
<210> 2207
<211> 11
<212> PRT
<213> Homo sapiens
<400> 2207
Ala Arg Asp Ala Met Ser Tyr Gly Met Asp Val
1 5 10
<210> 2208
<211> 11
<212> PRT
<213> Homo sapiens
<400> 2208
Ala Arg Asp Ala Ala Val Tyr Gly Ile Asp Val
1 5 10
<210> 2209
<211> 11
<212> PRT
<213> Homo sapiens
<400> 2209
Ala Arg Asp Leu Ile Ser Arg Gly Met Asp Val
1 5 10
<210> 2210
<211> 11
<212> PRT
<213> Homo sapiens
<400> 2210
Ala Arg Asp Arg Val Val Tyr Gly Met Asp Val
1 5 10
<210> 2211
<211> 11
<212> PRT
<213> Homo sapiens
<400> 2211
Ala Arg Asp Leu Val Ser Tyr Gly Met Asp Val
1 5 10
<210> 2212
<211> 11
<212> PRT
<213> Homo sapiens
<400> 2212
Ala Arg Asp Leu Val Val Tyr Gly Met Asp Val
1 5 10
<210> 2213
<211> 11
<212> PRT
<213> Homo sapiens
<400> 2213
Ala Arg Asp Ala Gln Asn Tyr Gly Met Asp Val
1 5 10
<210> 2214
<211> 11
<212> PRT
<213> Homo sapiens
<400> 2214
Ala Arg Asp Leu Gly Pro Tyr Gly Met Asp Val
1 5 10
<210> 2215
<211> 11
<212> PRT
<213> Homo sapiens
<400> 2215
Ala Arg Asp Tyr Gly Asp Tyr Tyr Phe Asp Tyr
1 5 10
<210> 2216
<211> 19
<212> PRT
<213> Homo sapiens
<400> 2216
Ala Arg Pro Gln Gly Gly Ser Ser Trp Tyr Arg Asp Tyr Tyr Tyr Gly
1 5 10 15
Met Asp Val
<210> 2217
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2217
Ala Lys Glu Gly Arg Pro Ser Asp Ile Val Val Val Val Ala Phe Asp
1 5 10 15
Tyr
<210> 2218
<211> 11
<212> PRT
<213> Homo sapiens
<400> 2218
Ala Arg Asp Tyr Gly Asp Phe Tyr Phe Asp Tyr
1 5 10
<210> 2219
<211> 21
<212> PRT
<213> Homo sapiens
<400> 2219
Ala Ser Pro Ala Ser Arg Gly Tyr Ser Gly Tyr Asp His Gly Tyr Tyr
1 5 10 15
Tyr Tyr Met Asp Val
20
<210> 2220
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2220
Ala Ala Pro His Cys Ser Gly Gly Ser Cys Leu Asp Ala Phe Asp Ile
1 5 10 15
<210> 2221
<211> 18
<212> PRT
<213> Homo sapiens
<400> 2221
Ala Arg Arg Gly Asp Gly Ser Ser Ser Ile Tyr Tyr Tyr Asn Tyr Met
1 5 10 15
Asp Val
<210> 2222
<211> 13
<212> PRT
<213> Homo sapiens
<400> 2222
Ala Arg Glu Phe Gly Asp Pro Glu Trp Tyr Phe Asp Tyr
1 5 10
<210> 2223
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2223
Ala Arg Asp Ser Pro Phe Ser Ala Leu Gly Ala Ser Asn Asp Tyr
1 5 10 15
<210> 2224
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2224
Ala Arg Asp Gly Ile Val Asp Thr Ala Leu Val Thr Trp Phe Asp Tyr
1 5 10 15
<210> 2225
<211> 31
<212> PRT
<213> Homo sapiens
<400> 2225
Ala Arg Gly Asn Arg Leu Leu Tyr Cys Ser Ser Thr Ser Cys Tyr Leu
1 5 10 15
Asp Ala Val Arg Gln Gly Tyr Tyr Tyr Tyr Tyr Tyr Met Asp Val
20 25 30
<210> 2226
<211> 20
<212> PRT
<213> Homo sapiens
<400> 2226
Ala Lys Val Thr Ala Pro Tyr Cys Ser Gly Gly Ser Cys Tyr Gly Gly
1 5 10 15
Asn Phe Asp Tyr
20
<210> 2227
<211> 19
<212> PRT
<213> Homo sapiens
<400> 2227
Ala Lys Ala Gly Val Arg Gly Ile Ala Ala Ala Gly Pro Asp Leu Asn
1 5 10 15
Phe Asp His
<210> 2228
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2228
Ala Arg Asp Phe Asp Asp Ser Ser Phe Trp Ala Phe Asp Tyr
1 5 10
<210> 2229
<211> 13
<212> PRT
<213> Homo sapiens
<400> 2229
Ala Arg Val Pro Arg Glu Gly Thr Pro Gly Phe Asp Pro
1 5 10
<210> 2230
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2230
Ala Arg Val Trp Gln Tyr Tyr Asp Ser Ser Gly Ser Phe Asp Tyr
1 5 10 15
<210> 2231
<211> 21
<212> PRT
<213> Homo sapiens
<400> 2231
Ala Arg His Ala Ala Ala Tyr Tyr Asp Arg Ser Gly Tyr Tyr Phe Ile
1 5 10 15
Glu Tyr Phe Gln His
20
<210> 2232
<211> 20
<212> PRT
<213> Homo sapiens
<400> 2232
Ala Lys Ala Ser Gly Ile Tyr Cys Ser Gly Gly Asp Cys Tyr Ser Tyr
1 5 10 15
Tyr Phe Asp Tyr
20
<210> 2233
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2233
Ala Arg Thr Met Tyr Tyr Tyr Asp Ser Ser Gly Ser Phe Asp Tyr
1 5 10 15
<210> 2234
<211> 20
<212> PRT
<213> Homo sapiens
<400> 2234
Ala Lys Ala Ser Gly Ile Tyr Cys Ser Gly Gly Asn Cys Tyr Ser Tyr
1 5 10 15
Tyr Phe Asp Tyr
20
<210> 2235
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2235
Ala Arg Val Gly Tyr Asp Ser Ser Gly Tyr Ser Gly Trp Tyr Phe Asp
1 5 10 15
Leu
<210> 2236
<211> 11
<212> PRT
<213> Homo sapiens
<400> 2236
Val Arg Asp Tyr Gly Asp Phe Tyr Phe Asp Tyr
1 5 10
<210> 2237
<211> 11
<212> PRT
<213> Homo sapiens
<400> 2237
Ala Arg Asp Tyr Gly Asp Tyr Tyr Phe Asp Tyr
1 5 10
<210> 2238
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2238
Ala Arg Lys Pro Leu Leu Tyr Ser Asp Phe Ser Pro Gly Ala Phe Asp
1 5 10 15
Ile
<210> 2239
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2239
Ala Arg Lys Pro Leu Leu Tyr Ser Asn Leu Ser Pro Gly Ala Phe Asp
1 5 10 15
Ile
<210> 2240
<211> 12
<212> PRT
<213> Homo sapiens
<400> 2240
Ala Arg Gly Glu Gly Trp Glu Leu Pro Tyr Asp Tyr
1 5 10
<210> 2241
<211> 24
<212> PRT
<213> Homo sapiens
<400> 2241
Ala Arg Glu Arg Pro Gly Gly Thr Tyr Ser Asn Thr Trp Tyr Thr Pro
1 5 10 15
Thr Asp Thr Asn Trp Phe Asp Thr
20
<210> 2242
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2242
Ala Arg Gly Glu Ala Val Ala Gly Thr Thr Gly Phe Phe Asp Tyr
1 5 10 15
<210> 2243
<211> 13
<212> PRT
<213> Homo sapiens
<400> 2243
Val Arg Asp Gly Gly Arg Pro Gly Asp Ala Phe Asp Ile
1 5 10
<210> 2244
<211> 12
<212> PRT
<213> Homo sapiens
<400> 2244
Ala Ile Gln Leu Trp Leu Arg Gly Gly Tyr Asp Tyr
1 5 10
<210> 2245
<211> 21
<212> PRT
<213> Homo sapiens
<400> 2245
Ala Arg Ser Phe Arg Asp Asp Pro Arg Ile Ala Val Ala Gly Pro Ala
1 5 10 15
Asp Ala Phe Asp Ile
20
<210> 2246
<211> 21
<212> PRT
<213> Homo sapiens
<400> 2246
Ala Arg Val Glu Asp Trp Gly Tyr Cys Ser Ser Thr Asn Cys Tyr Ser
1 5 10 15
Gly Ala Phe Asp Ile
20
<210> 2247
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2247
Ala Arg Glu Asp Tyr Tyr Asp Ser Ser Gly Ser Phe Asp Tyr
1 5 10
<210> 2248
<211> 18
<212> PRT
<213> Homo sapiens
<400> 2248
Ala Arg Gly Val Asn Pro Asp Asp Ile Leu Thr Gly Val Asp Ala Phe
1 5 10 15
Asp Ile
<210> 2249
<211> 11
<212> PRT
<213> Homo sapiens
<400> 2249
Ala Arg Gly Asp Gly Glu Leu Phe Phe Asp Gln
1 5 10
<210> 2250
<211> 11
<212> PRT
<213> Homo sapiens
<400> 2250
Thr Arg Trp Asp Gly Trp Ser Gln His Asp Tyr
1 5 10
<210> 2251
<211> 11
<212> PRT
<213> Homo sapiens
<400> 2251
Ala Arg Asp Phe Tyr His Asn Trp Phe Asp Pro
1 5 10
<210> 2252
<211> 20
<212> PRT
<213> Homo sapiens
<400> 2252
Ala Arg Asp Pro Ile Trp Phe Gly Glu Leu Leu Ser Pro Pro Phe Val
1 5 10 15
His Phe Asp Tyr
20
<210> 2253
<211> 20
<212> PRT
<213> Homo sapiens
<400> 2253
Ala Ser Gly Tyr Thr Gly Tyr Asp Tyr Phe Val Arg Gly Asp Tyr Tyr
1 5 10 15
Gly Leu Asp Val
20
<210> 2254
<211> 20
<212> PRT
<213> Homo sapiens
<400> 2254
Ala Arg Ala Asn His Glu Thr Thr Met Asp Thr Tyr Tyr Tyr Tyr Tyr
1 5 10 15
Tyr Met Asp Val
20
<210> 2255
<211> 12
<212> PRT
<213> Homo sapiens
<400> 2255
Ala Arg Glu Gly Met Gly Met Ala Ala Ala Gly Thr
1 5 10
<210> 2256
<211> 22
<212> PRT
<213> Homo sapiens
<400> 2256
Ala Arg Ala Pro Leu Phe Pro Thr Gly Val Leu Ala Gly Asp Tyr Tyr
1 5 10 15
Tyr Tyr Gly Met Asp Val
20
<210> 2257
<211> 13
<212> PRT
<213> Homo sapiens
<400> 2257
Ala Arg Glu Ser Gly Asp Thr Thr Met Ala Phe Asp Tyr
1 5 10
<210> 2258
<211> 10
<212> PRT
<213> Homo sapiens
<400> 2258
Ala Arg Asp Leu Ser Ala Ala Phe Asp Ile
1 5 10
<210> 2259
<211> 18
<212> PRT
<213> Homo sapiens
<400> 2259
Ala Arg Glu Gly Ala Arg Val Gly Ala Thr Tyr Asp Thr Tyr Tyr Phe
1 5 10 15
Asp Tyr
<210> 2260
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2260
Ala Ala Pro Tyr Cys Ser Gly Gly Ser Cys Ser Asp Ala Phe Asp Ile
1 5 10 15
<210> 2261
<211> 12
<212> PRT
<213> Homo sapiens
<400> 2261
Ala Arg Leu Gln Trp Leu Arg Gly Ala Phe Asp Ile
1 5 10
<210> 2262
<211> 18
<212> PRT
<213> Homo sapiens
<400> 2262
Ala Thr Ala His Pro Arg Arg Ile Gln Gly Val Phe Phe Leu Gly Pro
1 5 10 15
Gly Val
<210> 2263
<211> 18
<212> PRT
<213> Homo sapiens
<400> 2263
Ala Asn His Pro Leu Ala Ser Gly Asp Asp Tyr Tyr His Tyr Tyr Met
1 5 10 15
Asp Val
<210> 2264
<211> 13
<212> PRT
<213> Homo sapiens
<400> 2264
Ala Arg Ser Arg Pro Thr Pro Asp Trp Tyr Phe Asp Leu
1 5 10
<210> 2265
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2265
Ala Arg Val Asn Gln Ala Val Thr Thr Pro Phe Ser Met Asp Val
1 5 10 15
<210> 2266
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2266
Ala Arg Gly Gly Asp Thr Ala Met Gly Pro Glu Tyr Phe Asp Tyr
1 5 10 15
<210> 2267
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2267
Ala Arg Asp Ser Asp Val Asp Thr Ser Met Val Thr Trp Phe Asp Tyr
1 5 10 15
<210> 2268
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2268
Ala Lys Asp Pro Leu Ile Thr Gly Pro Thr Tyr Gln Tyr Phe His Tyr
1 5 10 15
<210> 2269
<211> 12
<212> PRT
<213> Homo sapiens
<400> 2269
Ala Ser Ser Ser Gly Tyr Leu Phe His Ser Asp Tyr
1 5 10
<210> 2270
<211> 12
<212> PRT
<213> Homo sapiens
<400> 2270
Ala Gly Gly Thr Trp Leu Arg Ser Ser Phe Asp Tyr
1 5 10
<210> 2271
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2271
Ala Lys Gly Gly Ala Tyr Ser Tyr Tyr Tyr Tyr Met Asp Val
1 5 10
<210> 2272
<211> 11
<212> PRT
<213> Homo sapiens
<400> 2272
Ala Arg Asp Leu Tyr Tyr Tyr Gly Met Asp Val
1 5 10
<210> 2273
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2273
Ala Arg Ala Asp Leu Gly Tyr Cys Thr Asn Gly Val Cys Tyr Val Asp
1 5 10 15
Tyr
<210> 2274
<211> 23
<212> PRT
<213> Homo sapiens
<400> 2274
Ala Arg Asp Ser Ser Glu Val Arg Asp His Pro Gly His Pro Gly Arg
1 5 10 15
Ser Val Gly Ala Phe Asp Ile
20
<210> 2275
<211> 25
<212> PRT
<213> Homo sapiens
<400> 2275
Ala Arg Glu Gly Glu Val Glu Gly Tyr Asn Asp Phe Trp Ser Gly Tyr
1 5 10 15
Ser Arg Asp Arg Tyr Tyr Phe Asp Tyr
20 25
<210> 2276
<211> 25
<212> PRT
<213> Homo sapiens
<400> 2276
Ala Arg Glu Gly Glu Val Glu Gly Tyr Tyr Asp Phe Trp Ser Gly Tyr
1 5 10 15
Ser Arg Asp Arg Tyr Tyr Phe Asp Tyr
20 25
<210> 2277
<211> 13
<212> PRT
<213> Homo sapiens
<400> 2277
Ala Arg Asp Val Ala Ser Asn Tyr Ala Tyr Phe Asp Leu
1 5 10
<210> 2278
<211> 13
<212> PRT
<213> Homo sapiens
<400> 2278
Ala Arg Leu Ser Asp Arg Trp Tyr Ser Pro Phe Asp Pro
1 5 10
<210> 2279
<211> 9
<212> PRT
<213> Homo sapiens
<400> 2279
Ala Arg Ile Ala Asn Tyr Met Asp Val
1 5
<210> 2280
<211> 20
<212> PRT
<213> Homo sapiens
<400> 2280
Ala Arg Pro Thr Ala Val Ala Ala Ala Gly Asn Tyr Phe Tyr Tyr Tyr
1 5 10 15
Gly Met Asp Val
20
<210> 2281
<211> 13
<212> PRT
<213> Homo sapiens
<400> 2281
Ala Arg Glu Arg Gly Tyr Asp Gly Gly Lys Thr Pro Pro
1 5 10
<210> 2282
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2282
Ala Arg Val Gly Gly Ala His Ser Gly Tyr Asp Gly Ser Phe Asp Tyr
1 5 10 15
<210> 2283
<211> 20
<212> PRT
<213> Homo sapiens
<400> 2283
Ala Lys Gln Ala Gly Pro Tyr Cys Ser Gly Gly Ser Cys Tyr Ser Ala
1 5 10 15
Pro Phe Asp Tyr
20
<210> 2284
<211> 11
<212> PRT
<213> Homo sapiens
<400> 2284
Ala Arg Asp Phe Gly Glu Phe Tyr Phe Asp Tyr
1 5 10
<210> 2285
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2285
Ala Lys Asp Pro Phe Pro Leu Ala Val Ala Gly Thr Gly Tyr Phe Asp
1 5 10 15
Tyr
<210> 2286
<211> 23
<212> PRT
<213> Homo sapiens
<400> 2286
Ala Arg Asp Ser Ser Glu Val Arg Asp His Pro Gly His Pro Gly Arg
1 5 10 15
Ser Val Gly Ala Phe Asp Ile
20
<210> 2287
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2287
Ala Arg Asp Leu Leu Asp Pro Gln Leu Asp Asp Ala Phe Asp Ile
1 5 10 15
<210> 2288
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2288
Val Lys Gly Val Glu Tyr Ser Ser Ser Ser Asn Phe Asp Tyr
1 5 10
<210> 2289
<211> 11
<212> PRT
<213> Homo sapiens
<400> 2289
Ala Arg Asp Thr Leu Gly Arg Gly Gly Asp Tyr
1 5 10
<210> 2290
<211> 19
<212> PRT
<213> Homo sapiens
<400> 2290
Ala Arg Glu Ser Asp Cys Gly Ser Thr Ser Cys Tyr Gln Val Gly Trp
1 5 10 15
Phe Asp Pro
<210> 2291
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2291
Ala Arg Gly Pro Glu Arg Gly Ile Val Gly Ala Thr Asp Tyr Phe Asp
1 5 10 15
Tyr
<210> 2292
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2292
Ala Lys Glu Pro Ile Gly Gln Pro Leu Leu Trp Trp Asp Tyr
1 5 10
<210> 2293
<211> 12
<212> PRT
<213> Homo sapiens
<400> 2293
Ala Arg Gly Pro Asn Leu Gln Asn Trp Phe Asp Pro
1 5 10
<210> 2294
<211> 11
<212> PRT
<213> Homo sapiens
<400> 2294
Ala Arg Asp Leu Met Ala Tyr Gly Met Asp Val
1 5 10
<210> 2295
<211> 11
<212> PRT
<213> Homo sapiens
<400> 2295
Ala Arg Asp Tyr Gly Asp Phe Tyr Phe Asp Phe
1 5 10
<210> 2296
<211> 13
<212> PRT
<213> Homo sapiens
<400> 2296
Ala Arg Glu Arg Tyr Phe Asp Leu Gly Gly Met Asp Val
1 5 10
<210> 2297
<211> 13
<212> PRT
<213> Homo sapiens
<400> 2297
Ala Arg Asp Val Gly Arg Val Thr Thr Trp Phe Asp Pro
1 5 10
<210> 2298
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2298
Ala Ser Glu Glu Asp Tyr Ser Asn Tyr Val Gly Trp Phe Asp Pro
1 5 10 15
<210> 2299
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2299
Ala Arg Asp Arg Gly Ser Ser Gly Trp Tyr Gly Trp Tyr Phe Asp Leu
1 5 10 15
<210> 2300
<211> 23
<212> PRT
<213> Homo sapiens
<400> 2300
Ala Arg Glu Gly Tyr Cys Ser Gly Gly Ser Cys Tyr Ser Gly Tyr Tyr
1 5 10 15
Tyr Tyr Tyr Gly Met Asp Val
20
<210> 2301
<211> 13
<212> PRT
<213> Homo sapiens
<400> 2301
Ala Arg Val Leu Pro Met Tyr Gly Asp Tyr Leu Asp Tyr
1 5 10
<210> 2302
<211> 11
<212> PRT
<213> Homo sapiens
<400> 2302
Ala Arg Asp Leu Asp Val Tyr Gly Leu Asp Val
1 5 10
<210> 2303
<211> 13
<212> PRT
<213> Homo sapiens
<400> 2303
Ala Arg Gly Pro Arg Tyr Ser Gly Thr His Phe Asp Tyr
1 5 10
<210> 2304
<211> 13
<212> PRT
<213> Homo sapiens
<400> 2304
Ala Arg Gly Pro Arg Tyr Ser Gly Thr Tyr Phe Asp Tyr
1 5 10
<210> 2305
<211> 13
<212> PRT
<213> Homo sapiens
<400> 2305
Ala Arg Gly Pro Arg Tyr Ser Gly Thr Tyr Phe Asp Tyr
1 5 10
<210> 2306
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2306
Ala Arg Asp Pro Tyr Gly Tyr Ser Ser Ile Trp Asp Gly Gln Gly Gly
1 5 10 15
His
<210> 2307
<211> 26
<212> PRT
<213> Homo sapiens
<400> 2307
Ala Arg Gly Gly Tyr Cys Ser Asp Gly Ser Cys Tyr Val Gln Asp Arg
1 5 10 15
Leu Ile Tyr Tyr Tyr Ser Gly Leu Asp Val
20 25
<210> 2308
<211> 22
<212> PRT
<213> Homo sapiens
<400> 2308
Ala Arg Asp Arg Arg Arg Arg Tyr Cys Thr Asn Gly Val Cys Tyr Arg
1 5 10 15
Pro Glu Glu Ile Asp Tyr
20
<210> 2309
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2309
Ala Arg Asp Pro Phe Pro Gly Ala Val Ala Gly Thr Gly Tyr Leu Gln
1 5 10 15
Tyr
<210> 2310
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2310
Ala Lys Ser Ser Gly Ser Tyr Tyr Tyr Tyr Tyr Tyr Gly Met Asp Val
1 5 10 15
<210> 2311
<211> 13
<212> PRT
<213> Homo sapiens
<400> 2311
Ala Arg Leu His Cys Gly Gly Asp Cys Tyr Leu Asp Tyr
1 5 10
<210> 2312
<211> 20
<212> PRT
<213> Homo sapiens
<400> 2312
Ala Lys Gly Ser Gly Ser Gly Ser Tyr Pro Asn Tyr Tyr Tyr Tyr Tyr
1 5 10 15
Gly Met Asp Val
20
<210> 2313
<211> 11
<212> PRT
<213> Homo sapiens
<400> 2313
Ala Arg Asp Tyr Gly Asp Leu Tyr Phe Asp Tyr
1 5 10
<210> 2314
<211> 27
<212> PRT
<213> Homo sapiens
<400> 2314
Ala Lys Asp Gln Ala Tyr Tyr Asp Ile Leu Thr Gly Tyr Leu Asn Pro
1 5 10 15
Pro Lys Asn Tyr Tyr Tyr Tyr Gly Met Asp Val
20 25
<210> 2315
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2315
Ala Thr Ala Phe Ser Ile Phe Gly Val Val Pro Pro Asp Tyr
1 5 10
<210> 2316
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2316
Ala Arg Gln Gly Asp Cys Ser Thr Thr Ser Cys Ala Tyr Asp Tyr
1 5 10 15
<210> 2317
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2317
Ala Lys Asp Arg Thr Gly Asn Tyr Tyr Tyr Gly Met Asp Val
1 5 10
<210> 2318
<211> 18
<212> PRT
<213> Homo sapiens
<400> 2318
Ala Lys Asp Arg Tyr Tyr Glu Phe Trp Ser Gly Tyr Ser Asn Trp Phe
1 5 10 15
Asp Pro
<210> 2319
<211> 18
<212> PRT
<213> Homo sapiens
<400> 2319
Ala Arg Val Asn Tyr Tyr Asp Ser Ser Gly Tyr Pro Ser Phe His Phe
1 5 10 15
Asp Tyr
<210> 2320
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2320
Ala Arg Glu Met Pro Ala Ala Met Gly Tyr Tyr Tyr Tyr Gly Met Asp
1 5 10 15
Val
<210> 2321
<211> 13
<212> PRT
<213> Homo sapiens
<400> 2321
Ala Lys Ala Asn Lys Tyr Ser Ser Ser Glu Phe Asp Phe
1 5 10
<210> 2322
<211> 11
<212> PRT
<213> Homo sapiens
<400> 2322
Ala Arg Asp Phe Gly Asp Phe Tyr Phe Asp Tyr
1 5 10
<210> 2323
<211> 19
<212> PRT
<213> Homo sapiens
<400> 2323
Ala Thr Glu Ser Trp Val Tyr Gly Ser Gly Ser Tyr Ser Ser Gly Ala
1 5 10 15
Phe Asp Ile
<210> 2324
<211> 13
<212> PRT
<213> Homo sapiens
<400> 2324
Ala Arg Gly Pro Arg Tyr Ser Gly Thr Tyr Phe Asp Tyr
1 5 10
<210> 2325
<211> 13
<212> PRT
<213> Homo sapiens
<400> 2325
Ala Arg Gly Pro Arg Tyr Ser Gly Thr Tyr Phe Asp Tyr
1 5 10
<210> 2326
<211> 13
<212> PRT
<213> Homo sapiens
<400> 2326
Ala Arg Gly Pro Arg Tyr Ser Gly Thr Tyr Phe Asp Tyr
1 5 10
<210> 2327
<211> 13
<212> PRT
<213> Homo sapiens
<400> 2327
Ala Arg Gly Pro Arg Tyr Ser Gly Thr Tyr Phe Asp Tyr
1 5 10
<210> 2328
<211> 13
<212> PRT
<213> Homo sapiens
<400> 2328
Ala Arg Gly Pro Arg Tyr Ser Gly Thr Tyr Phe Asp Tyr
1 5 10
<210> 2329
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2329
Ala Val Tyr Tyr Tyr Asp Ser Gly Ser Pro Gly Trp Phe Asp Pro
1 5 10 15
<210> 2330
<211> 18
<212> PRT
<213> Homo sapiens
<400> 2330
Ala Arg Asp Phe Arg Tyr Cys Ser Ser Thr Arg Cys Tyr Phe Trp Phe
1 5 10 15
Asp Pro
<210> 2331
<211> 12
<212> PRT
<213> Homo sapiens
<400> 2331
Ala Arg Trp Tyr Asp Ser Thr Gly Ser Ile Asp Tyr
1 5 10
<210> 2332
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2332
Ala Lys Asp Gln Gly Tyr Ser Tyr Gly Asn Tyr Phe Asp Tyr
1 5 10
<210> 2333
<211> 11
<212> PRT
<213> Homo sapiens
<400> 2333
Ala Leu Arg Asn Gln Trp Asp Leu Leu Val Tyr
1 5 10
<210> 2334
<211> 14
<212> PRT
<213> Mus musculus
<400> 2334
Ala Arg Arg Gly Tyr Gly Ser Ser Tyr Thr Trp Phe Ala Tyr
1 5 10
<210> 2335
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2335
Ala Arg Val Ser Gly Tyr Asp Ser Ser Gly Tyr Trp Gly Asp Tyr
1 5 10 15
<210> 2336
<211> 12
<212> PRT
<213> Homo sapiens
<400> 2336
Ala Arg Asp Gly Glu Leu Leu Gly Trp Phe Asp Pro
1 5 10
<210> 2337
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2337
Thr Arg Val Arg Arg Leu Trp Phe Gly Ser Tyr Tyr Tyr Gly Met Asp
1 5 10 15
Val
<210> 2338
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2338
Thr Arg Val Arg Arg Leu Trp Phe Gly Ser Tyr Tyr Tyr Gly Met Asp
1 5 10 15
Val
<210> 2339
<211> 13
<212> PRT
<213> Homo sapiens
<400> 2339
Ala Arg Ala Ser Val Ser Thr Ile Thr Asp Phe Asp Tyr
1 5 10
<210> 2340
<211> 13
<212> PRT
<213> Homo sapiens
<400> 2340
Ala Arg Ala Ser Val Ala Thr Ile Thr Asp Phe Asp Tyr
1 5 10
<210> 2341
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2341
Ala Arg Pro Gln Ser Gly Gly Tyr Tyr Ala Pro Leu Asp Tyr
1 5 10
<210> 2342
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2342
Ala Lys Val Ser Ala Thr Tyr Tyr Tyr Tyr Tyr Tyr Gly Met Asp Val
1 5 10 15
<210> 2343
<211> 19
<212> PRT
<213> Homo sapiens
<400> 2343
Ala Arg Asp Thr Ala Thr Tyr Val Leu Leu Trp Ser Gly Asp Phe Asn
1 5 10 15
Leu Asp Tyr
<210> 2344
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2344
Ala Arg Gly His Thr Gly Asn Tyr Tyr Tyr Gly Met Asp Val
1 5 10
<210> 2345
<211> 20
<212> PRT
<213> Homo sapiens
<400> 2345
Ala Lys Gly Gly Asp Ser Ser Gly Trp Ala Trp Asp Gly Asp Asn Pro
1 5 10 15
Pro Thr Asp Tyr
20
<210> 2346
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2346
Ala Met Gly Pro Phe Gly Glu Leu Leu Pro Tyr Tyr Phe Asp Tyr
1 5 10 15
<210> 2347
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2347
Ala Ala Ala Pro Ala Val Met Thr Ala Gly Trp Phe Asp Pro
1 5 10
<210> 2348
<211> 10
<212> PRT
<213> Homo sapiens
<400> 2348
Val Arg Gly Ala Met Ala Trp Phe Asp Pro
1 5 10
<210> 2349
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2349
Ala Thr Gln Pro Ala Ala Ile Gly Gly Thr Pro Pro Tyr Tyr
1 5 10
<210> 2350
<211> 21
<212> PRT
<213> Homo sapiens
<400> 2350
Ala Arg Asp Gln Gly Pro Thr Tyr Tyr Tyr Gly Ser Gly Ser Pro His
1 5 10 15
Tyr Gly Met Asp Val
20
<210> 2351
<211> 20
<212> PRT
<213> Homo sapiens
<400> 2351
Ala Lys Gly Gly Asp Ser Ser Gly Trp Ala Trp Asp Gly Asp Asn Pro
1 5 10 15
Pro Thr Asp Tyr
20
<210> 2352
<211> 21
<212> PRT
<213> Homo sapiens
<400> 2352
Ala Thr Ser Phe Pro Ile Arg Gly Asp Pro Ser Tyr Tyr Tyr Tyr Tyr
1 5 10 15
Tyr Gly Met Asp Val
20
<210> 2353
<211> 12
<212> PRT
<213> Homo sapiens
<400> 2353
Ala Ile Tyr Gly Tyr Tyr Tyr Tyr Gly Leu Asp Val
1 5 10
<210> 2354
<211> 20
<212> PRT
<213> Homo sapiens
<400> 2354
Ala Lys Gly Gly Asp Ser Ser Gly Trp Ala Trp Asp Gly Asp Asn Pro
1 5 10 15
Pro Thr Asp Tyr
20
<210> 2355
<211> 13
<212> PRT
<213> Homo sapiens
<400> 2355
Ala Arg Pro Thr Ala Gly Ala Gly Gly Ala Phe Asp Ile
1 5 10
<210> 2356
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2356
Ala Arg Thr Glu Trp Leu Leu Ser Asp Asn Trp Phe Asp Ser
1 5 10
<210> 2357
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2357
Ala Arg Gly Gly Leu Val Pro Ala Ala Arg Asn Ala Phe Asp Ile
1 5 10 15
<210> 2358
<211> 13
<212> PRT
<213> Homo sapiens
<400> 2358
Ala Arg Pro Thr Ala Gly Ala Gly Gly Ala Phe Asp Thr
1 5 10
<210> 2359
<211> 20
<212> PRT
<213> Homo sapiens
<400> 2359
Ala Arg Asp Leu Pro Ile Lys Val Val Val Pro Ala Ala Asp Tyr Asn
1 5 10 15
Trp Phe Asp Pro
20
<210> 2360
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2360
Ala His Arg Arg Gly Ile Leu Thr Glu Asp Ala Phe Asp Ile
1 5 10
<210> 2361
<211> 11
<212> PRT
<213> Homo sapiens
<400> 2361
Ala Arg Asp Leu Asn Glu His Gly Leu Asp Val
1 5 10
<210> 2362
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2362
Ala Arg Gly Thr Leu Ile Pro Ala His Arg Gly Ala Phe Asp Ile
1 5 10 15
<210> 2363
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2363
Ala Arg Ala Arg Pro Asp Tyr Tyr Tyr Tyr Tyr Ala Met Asp Val
1 5 10 15
<210> 2364
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2364
Ala Lys Ala His Ser Thr Gly His Gln Tyr Tyr Tyr Gly Met Asp Val
1 5 10 15
<210> 2365
<211> 23
<212> PRT
<213> Homo sapiens
<400> 2365
Ala Arg Val Val Val Leu Gly Tyr Gly Arg Pro Asn Asn Tyr Tyr Asp
1 5 10 15
Gly Arg Asn Val Trp Asp Tyr
20
<210> 2366
<211> 9
<212> PRT
<213> Homo sapiens
<400> 2366
Ala Arg Gly Val Val Thr Tyr Asp Tyr
1 5
<210> 2367
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2367
Ala Arg Gly Arg Gly Tyr Ser Asn Tyr Gly Ala Ser Tyr Tyr Met Asp
1 5 10 15
Val
<210> 2368
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2368
Ala Lys Gly Arg Gly Ala Gly Tyr Thr Ser Tyr Met Asp Val
1 5 10
<210> 2369
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2369
Ala Arg Met Arg Thr Gly Trp Pro Thr His Gly Arg Pro Asp Asp Phe
1 5 10 15
<210> 2370
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2370
Ala Arg Ser Tyr Asp Ile Leu Thr Gly Tyr Arg Asp Ala Phe Asp Ile
1 5 10 15
<210> 2371
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2371
Ala Arg Val Gly Tyr Ser Gln Gly Tyr Tyr Tyr Tyr Tyr Met Asp Val
1 5 10 15
<210> 2372
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2372
Ala Ala Pro His Cys Asn Arg Thr Ser Cys Tyr Asp Ala Phe Asp Leu
1 5 10 15
<210> 2373
<211> 18
<212> PRT
<213> Homo sapiens
<400> 2373
Ala Arg Val Gly Val Ser Gly Phe Lys Ser Gly Ser Asn Trp Tyr Phe
1 5 10 15
Asp Leu
<210> 2374
<211> 11
<212> PRT
<213> Homo sapiens
<400> 2374
Ala Arg Asp Leu Val Thr Tyr Gly Leu Asp Val
1 5 10
<210> 2375
<211> 22
<212> PRT
<213> Homo sapiens
<400> 2375
Ala Val Ile Met Ser Pro Ile Pro Arg Tyr Ser Gly Tyr Asp Trp Ala
1 5 10 15
Gly Gly Ala Phe Asp Ile
20
<210> 2376
<211> 20
<212> PRT
<213> Homo sapiens
<400> 2376
Ala Lys Asn Leu Gly Pro Tyr Cys Ser Gly Gly Thr Cys Tyr Ser Leu
1 5 10 15
Val Gly Asp Tyr
20
<210> 2377
<211> 22
<212> PRT
<213> Homo sapiens
<400> 2377
Ala Val Ile Met Ser Pro Ile Pro Arg Tyr Ser Gly Tyr Asp Trp Ala
1 5 10 15
Gly Asp Ala Phe Asp Ile
20
<210> 2378
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2378
Ala Arg Met Arg Ser Gly Trp Pro Thr His Gly Arg Pro Asp Asp Phe
1 5 10 15
<210> 2379
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2379
Ala Lys Asp Ile Ile Arg Gln Gly Glu Asp Gly Met Asp Val
1 5 10
<210> 2380
<211> 10
<212> PRT
<213> Homo sapiens
<400> 2380
Val Lys Gly Leu Phe Asp Trp Phe Pro Leu
1 5 10
<210> 2381
<211> 12
<212> PRT
<213> Homo sapiens
<400> 2381
Ala Arg Leu Gly Phe Tyr Tyr Gly Gly Ala Asp Tyr
1 5 10
<210> 2382
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2382
Ala Lys Gly Val Asp Tyr Gly Gly Lys Leu Ala Tyr Phe Asp Ser
1 5 10 15
<210> 2383
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2383
Ala Arg Asp Ile Asp Ser Gly Tyr Asp Pro Thr Pro Val Phe Asp Tyr
1 5 10 15
<210> 2384
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2384
Ala Arg Val Leu Tyr Asp Ser Ser Gly Phe Tyr Asn Trp Phe Asp Pro
1 5 10 15
<210> 2385
<211> 10
<212> PRT
<213> Homo sapiens
<400> 2385
Ala Arg Asp Phe Leu Arg Trp His Asp Leu
1 5 10
<210> 2386
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2386
Ala Arg Gly Arg Gly Tyr Ser Asn Tyr Gly Ala Ser Tyr Tyr Met Asp
1 5 10 15
Val
<210> 2387
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2387
Ala Arg Ile Leu Val Ile Phe Thr Leu Asn Trp Phe Asp Pro
1 5 10
<210> 2388
<211> 22
<212> PRT
<213> Homo sapiens
<400> 2388
Thr Thr Ala Gly Ser Tyr Tyr Tyr Asp Thr Val Gly Pro Gly Leu Pro
1 5 10 15
Glu Gly Lys Phe Asp Tyr
20
<210> 2389
<211> 10
<212> PRT
<213> Homo sapiens
<400> 2389
Ala Arg Asp Phe Leu Arg Trp His Asp Leu
1 5 10
<210> 2390
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2390
Ala Gly Ser Pro Val Pro Pro Thr Ile Val Gly Ala Ser Tyr
1 5 10
<210> 2391
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2391
Ala Arg Arg Gly Glu Ala Ala Gly Ile Trp Tyr Phe Asp Leu
1 5 10
<210> 2392
<211> 18
<212> PRT
<213> Homo sapiens
<400> 2392
Ala Lys Glu Gly Gly Ser Gly Ser Leu Arg Tyr Tyr Tyr Tyr Gly Met
1 5 10 15
Asp Val
<210> 2393
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2393
Ala Arg Arg Ser Tyr Arg Ser Ser Trp Tyr Tyr Tyr Tyr Gly Met Asp
1 5 10 15
Val
<210> 2394
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2394
Ala Arg Ser Thr Ser Gly Ser Tyr Tyr Tyr Gly Met Asp Val
1 5 10
<210> 2395
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2395
Ala Arg Asp Trp Ala Pro Thr Tyr Tyr Asp Met Pro Ser Ala Phe Asp
1 5 10 15
Ile
<210> 2396
<211> 12
<212> PRT
<213> Homo sapiens
<400> 2396
Ala Arg Ile Gly Ser Tyr Pro Glu Tyr Phe Gln His
1 5 10
<210> 2397
<211> 13
<212> PRT
<213> Homo sapiens
<400> 2397
Ala Arg Gly Gly Ser Gly Ser Tyr Ser Leu Phe Asp Tyr
1 5 10
<210> 2398
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2398
Ala Arg Ser Thr Ser Gly Ser Tyr Tyr Tyr Gly Met Asp Val
1 5 10
<210> 2399
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2399
Ala Arg Ser Thr Ser Gly Ser Tyr Tyr Tyr Gly Met Asp Val
1 5 10
<210> 2400
<211> 11
<212> PRT
<213> Homo sapiens
<400> 2400
Ala Arg Asp Leu Val Thr Tyr Gly Leu Asp Val
1 5 10
<210> 2401
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2401
Ala Arg Ile Gly His Phe Asp Ser Ser Gly Tyr Tyr Leu Asp Tyr
1 5 10 15
<210> 2402
<211> 12
<212> PRT
<213> Homo sapiens
<400> 2402
Ala Arg Leu Ser Gly Ser Ser Trp Asp Phe Asp Tyr
1 5 10
<210> 2403
<211> 22
<212> PRT
<213> Homo sapiens
<400> 2403
Ala Arg Arg Arg Ser Ser Ser Arg Tyr Ser Ser Gly Trp Tyr Met Tyr
1 5 10 15
Tyr Tyr Tyr Met Asp Val
20
<210> 2404
<211> 12
<212> PRT
<213> Homo sapiens
<400> 2404
Ala Arg Leu Ser Gly Ser Ser Trp Asp Phe Asp Tyr
1 5 10
<210> 2405
<211> 12
<212> PRT
<213> Homo sapiens
<400> 2405
Ala His Arg Leu Trp Phe Arg Asp Ala Phe Asp Ile
1 5 10
<210> 2406
<211> 12
<212> PRT
<213> Homo sapiens
<400> 2406
Ala Arg Val Gly Ser Ser Ser Trp Tyr Phe Asp Tyr
1 5 10
<210> 2407
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2407
Ala Arg Ala Asp Thr Met Val Arg Gly Thr Tyr Phe Glu Tyr
1 5 10
<210> 2408
<211> 10
<212> PRT
<213> Homo sapiens
<400> 2408
Ala Arg Gly Gly Ala Thr Asn Phe Asp Tyr
1 5 10
<210> 2409
<211> 19
<212> PRT
<213> Homo sapiens
<400> 2409
Thr Lys Ala Ser Arg Tyr Cys Ser Ser Thr Ile Cys Tyr Trp Asn Trp
1 5 10 15
Phe Asp Pro
<210> 2410
<211> 19
<212> PRT
<213> Homo sapiens
<400> 2410
Ala Arg Glu Ala Arg Ser Arg Tyr Phe Asp Trp Leu Pro Ser Tyr Tyr
1 5 10 15
Phe Asp Tyr
<210> 2411
<211> 22
<212> PRT
<213> Homo sapiens
<400> 2411
Ala Arg Arg Arg Ser Ser Ser Arg Tyr Ser Ser Gly Trp Tyr Met Tyr
1 5 10 15
Tyr Tyr Tyr Met Asp Val
20
<210> 2412
<211> 20
<212> PRT
<213> Homo sapiens
<400> 2412
Ala Lys Gly Gly Asp Gly Ser Gly Trp Ala Trp Asp Gly Asp Asn Pro
1 5 10 15
Pro Thr Asp Tyr
20
<210> 2413
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2413
Ala Ala Pro Tyr Cys Ser Ser Ile Ser Cys Asn Asp Gly Phe Asp Ile
1 5 10 15
<210> 2414
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2414
Ala Arg Pro Asp Tyr Ser Ser Gly Trp Phe Ser Tyr Trp Tyr Phe Asp
1 5 10 15
Leu
<210> 2415
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2415
Ala Thr Gly Phe Ala Val Phe Gly Arg Ala Ala Val Pro Tyr
1 5 10
<210> 2416
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2416
Ala Arg Gly Ser Ala Gly Asn Tyr Tyr Tyr Gly Met Asp Val
1 5 10
<210> 2417
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2417
Ala Ser Ala Leu Arg Glu Arg Gly Val Gln Leu Trp Ser Val
1 5 10
<210> 2418
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2418
Ala Arg Asp Gln Glu Trp Phe Arg Glu Leu Phe Leu Phe Asp Tyr
1 5 10 15
<210> 2419
<211> 21
<212> PRT
<213> Homo sapiens
<400> 2419
Ala Arg Val Asn Gly Asn Ser Asn Trp Asn Phe Gly Ser Tyr Tyr Tyr
1 5 10 15
Tyr Tyr Met Asp Val
20
<210> 2420
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2420
Ala Arg Ile Gly His Phe Asp Ser Ser Gly Tyr Tyr Leu Asp Tyr
1 5 10 15
<210> 2421
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2421
Ala Arg Trp Leu Gln Leu Arg Ser Asp Tyr Tyr Tyr Phe Gly Met Asp
1 5 10 15
Val
<210> 2422
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2422
Ala Arg Thr Ser His Tyr Asp Ser Ser Gly Ser Tyr Phe Glu Tyr
1 5 10 15
<210> 2423
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2423
Ala Arg Pro Tyr Thr Gly Ser Tyr Lys Ser Tyr Met Asp Val
1 5 10
<210> 2424
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2424
Ala Arg Ala Pro Arg Glu Arg Leu Gln Trp Gly Glu Tyr Tyr Phe Asp
1 5 10 15
Tyr
<210> 2425
<211> 11
<212> PRT
<213> Homo sapiens
<400> 2425
Ala Lys Asp Gly Ser Ile Ala Ala Ala Asp Tyr
1 5 10
<210> 2426
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2426
Ala Thr His Arg Cys Ser Gly Gly Phe Cys Tyr Leu Ala Tyr
1 5 10
<210> 2427
<211> 21
<212> PRT
<213> Homo sapiens
<400> 2427
Ala Arg Asp Gln Ser Gln Gly Ala Tyr Ile Leu Thr Gly Tyr Arg Gly
1 5 10 15
Tyr Gly Met Asp Val
20
<210> 2428
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2428
Ala Arg Pro Pro Gln Ala Ala Arg Ile His Tyr Tyr Tyr Tyr Met Asp
1 5 10 15
Val
<210> 2429
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2429
Ala Lys Gly Arg Gly Ala Gly Tyr Thr Ser Tyr Met Asp Val
1 5 10
<210> 2430
<211> 6
<212> PRT
<213> Homo sapiens
<400> 2430
Ala Arg Glu Ser Thr Gln
1 5
<210> 2431
<211> 11
<212> PRT
<213> Homo sapiens
<400> 2431
Ala His Arg Ala Val Ile Leu Asn Phe Asp His
1 5 10
<210> 2432
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2432
Ala Arg Pro Arg Ser Gly Ser Tyr Tyr Ala Tyr Phe Asp Tyr
1 5 10
<210> 2433
<211> 18
<212> PRT
<213> Homo sapiens
<400> 2433
Ala Lys Val Gly Tyr Thr Ile Ser Arg Gln Trp Leu Val Gly Glu Phe
1 5 10 15
Asp Tyr
<210> 2434
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2434
Ala Arg Arg Gly Glu Ala Ala Gly Ile Trp Tyr Phe Asp Leu
1 5 10
<210> 2435
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2435
Ala Arg Gln Ser Arg Gly Tyr Ser Tyr Ala Trp Ser Phe Asp Tyr
1 5 10 15
<210> 2436
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2436
Ala Gly Ser Ser Gly Glu Gly Gly Leu Tyr Tyr Tyr Tyr Gly Met Asp
1 5 10 15
Val
<210> 2437
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2437
Ala Arg Asp Ser Gly Gly Asn Tyr Gly Asp Ser Tyr Phe Asp Tyr
1 5 10 15
<210> 2438
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2438
Ala Arg Gly Ser Ala Gly Asn Tyr Tyr Tyr Gly Met Asp Val
1 5 10
<210> 2439
<211> 18
<212> PRT
<213> Homo sapiens
<400> 2439
Ala Arg Ile Val Leu Gly Ala Ser Gly Thr Tyr Pro Ser Pro Gly Phe
1 5 10 15
Asp Pro
<210> 2440
<211> 12
<212> PRT
<213> Homo sapiens
<400> 2440
Ala Gly Ser Pro Trp Leu Arg Gly Asp Ile Asp Tyr
1 5 10
<210> 2441
<211> 20
<212> PRT
<213> Homo sapiens
<400> 2441
Ala Arg Asp Pro Ser Tyr Cys Ser Ser Thr Arg Cys Tyr Thr Val Gly
1 5 10 15
Trp Phe Asp Pro
20
<210> 2442
<211> 13
<212> PRT
<213> Homo sapiens
<400> 2442
Ala Arg Gly His Val Ala Ala Trp Glu Ser Cys Tyr Tyr
1 5 10
<210> 2443
<211> 23
<212> PRT
<213> Homo sapiens
<400> 2443
Ala Arg Ala Arg Gly Pro Ser Glu Gln Tyr Tyr Asp Leu Leu Thr Gly
1 5 10 15
Tyr Tyr Asp Ala Phe Asp Ile
20
<210> 2444
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2444
Ala Gln Met Gly Pro Leu Gly Ser Thr Ser Ser Ala Ala Asp Tyr
1 5 10 15
<210> 2445
<211> 23
<212> PRT
<213> Homo sapiens
<400> 2445
Ala Arg Glu Ala Arg Tyr Phe Asp Trp Ile Phe Glu Gly Ser Asp Tyr
1 5 10 15
Tyr Tyr Tyr Gly Met Asp Val
20
<210> 2446
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2446
Ala Arg Arg Ser Tyr Arg Ser Ser Trp Tyr Tyr Tyr Tyr Gly Met Asp
1 5 10 15
Val
<210> 2447
<211> 20
<212> PRT
<213> Homo sapiens
<400> 2447
Ile Arg Asp Tyr Asp Phe Trp Gly Gly Tyr Tyr Tyr His Pro Leu Arg
1 5 10 15
Ala Phe Asp Ile
20
<210> 2448
<211> 11
<212> PRT
<213> Homo sapiens
<400> 2448
Ala Arg His Gln Ile Val Val Leu Phe Asp Met
1 5 10
<210> 2449
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2449
Ala Ile Thr Tyr Tyr Tyr Asp Ser Ser Gly Tyr Trp Trp Asp Asp
1 5 10 15
<210> 2450
<211> 18
<212> PRT
<213> Homo sapiens
<400> 2450
Ala Gly Glu Glu Val Arg Gly Val Lys Leu Tyr Tyr Tyr Tyr Ala Met
1 5 10 15
Asp Val
<210> 2451
<211> 12
<212> PRT
<213> Homo sapiens
<400> 2451
Ala Arg Asp Arg Gly Trp Asn Tyr Gly Leu Asp Tyr
1 5 10
<210> 2452
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2452
Ala Arg Asp Val Pro Thr Thr Val Thr Ala Phe Thr Val Phe Thr Tyr
1 5 10 15
<210> 2453
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2453
Ala Arg Val Pro Val Met Val Arg Gly Val Tyr Phe Asp Tyr
1 5 10
<210> 2454
<211> 12
<212> PRT
<213> Homo sapiens
<400> 2454
Ala Arg Gly Tyr Gly Leu Thr Tyr Tyr Met Asp Val
1 5 10
<210> 2455
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2455
Ala Arg Met Arg Ser Gly Trp Pro Thr His Gly Arg Pro Asp Asp Phe
1 5 10 15
<210> 2456
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2456
Ala Lys Asn Glu Arg Ile Thr Met Leu Val Val Val Thr Leu Phe Asp
1 5 10 15
Tyr
<210> 2457
<211> 18
<212> PRT
<213> Homo sapiens
<400> 2457
Ala Arg Asp Pro Ser Ala Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Gly
1 5 10 15
Asp Val
<210> 2458
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2458
Ala Arg Asp Ile Asp Ser Gly Tyr Asp Pro Thr Pro Val Phe Asp Tyr
1 5 10 15
<210> 2459
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2459
Ala Ser Arg Trp Gly Asp Tyr Phe Asp Ser Ser Gly Ala Tyr Asp Ser
1 5 10 15
<210> 2460
<211> 20
<212> PRT
<213> Homo sapiens
<400> 2460
Ala Arg Asp Pro Val Trp Val Asp Gly Glu Leu Leu Ser Gly Gly Ile
1 5 10 15
Pro Phe Asp Tyr
20
<210> 2461
<211> 21
<212> PRT
<213> Homo sapiens
<400> 2461
Ala Ile Leu Trp Arg Gly Ser Ser Trp Ala Asp Arg His Tyr Tyr Tyr
1 5 10 15
Tyr Ser Met Asp Val
20
<210> 2462
<211> 10
<212> PRT
<213> Homo sapiens
<400> 2462
Ala Arg Asp Leu Gly Arg Gly Leu Asp Pro
1 5 10
<210> 2463
<211> 10
<212> PRT
<213> Homo sapiens
<400> 2463
Val Lys Gly Leu Phe Asp Trp Phe Pro Leu
1 5 10
<210> 2464
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2464
Ala Thr Gly Tyr Ile Gly Thr Tyr Tyr Tyr Tyr Met Asp Val
1 5 10
<210> 2465
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2465
Ala Lys Val Ser Ser Ile Thr Ser Leu Leu Gly Tyr Tyr Phe Asp Ser
1 5 10 15
<210> 2466
<211> 9
<212> PRT
<213> Homo sapiens
<400> 2466
Ala Arg Gly Val Val Thr Tyr Asp Tyr
1 5
<210> 2467
<211> 12
<212> PRT
<213> Homo sapiens
<400> 2467
Ala Arg Gly Asp Gly Tyr Arg Ser Gln Phe Asp Pro
1 5 10
<210> 2468
<211> 12
<212> PRT
<213> Homo sapiens
<400> 2468
Ala His Arg Leu Trp Phe Arg Asp Ala Phe Asp Ile
1 5 10
<210> 2469
<211> 21
<212> PRT
<213> Homo sapiens
<400> 2469
Ala Arg Val Glu Gly Asp Trp Leu Leu Gly Gly Pro Tyr Tyr His Tyr
1 5 10 15
Tyr Gly Met Asp Val
20
<210> 2470
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2470
Ala Arg Ile Leu Val Ile Phe Thr Leu Asn Trp Phe Asp Pro
1 5 10
<210> 2471
<211> 12
<212> PRT
<213> Homo sapiens
<400> 2471
Ala Arg Leu Gly Gly Ser Ser Trp His Phe Asp Tyr
1 5 10
<210> 2472
<211> 23
<212> PRT
<213> Homo sapiens
<400> 2472
Ala Arg His Asp Gly Ser Gly Glu Met Asp Thr Ile Thr Trp Gly Pro
1 5 10 15
Ile Tyr Tyr Tyr Met Asp Val
20
<210> 2473
<211> 12
<212> PRT
<213> Homo sapiens
<400> 2473
Ala His Arg Leu Trp Phe Arg Asp Ala Phe Asp Ile
1 5 10
<210> 2474
<211> 12
<212> PRT
<213> Homo sapiens
<400> 2474
Ala Met Gly Pro Ser Ala Phe Ser Trp Leu Asp Pro
1 5 10
<210> 2475
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2475
Ala Arg Ser Thr Ser Gly Ser Tyr Tyr Tyr Gly Met Asp Val
1 5 10
<210> 2476
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2476
Ala His Arg Pro Pro Ser Tyr His Gly Trp Cys Tyr Phe Asp Tyr
1 5 10 15
<210> 2477
<211> 10
<212> PRT
<213> Homo sapiens
<400> 2477
Ala Arg Val Gln Arg Arg Arg Leu Asp Tyr
1 5 10
<210> 2478
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2478
Ala Arg Pro Pro Gln Ala Ala Arg Ile His Tyr Tyr Tyr Tyr Met Asp
1 5 10 15
Val
<210> 2479
<211> 12
<212> PRT
<213> Homo sapiens
<400> 2479
Ala Arg Arg Phe Tyr Gly Pro Ser Ser Phe Asp Tyr
1 5 10
<210> 2480
<211> 18
<212> PRT
<213> Homo sapiens
<400> 2480
Ala Arg Gly Gly Glu Trp Arg Ile Val Pro Gly Gly Arg Asp Tyr Phe
1 5 10 15
Asp Tyr
<210> 2481
<211> 24
<212> PRT
<213> Homo sapiens
<400> 2481
Ala Arg Leu Gly Val Ser Lys Tyr Cys Ser Gly Gly Arg Cys Leu Ser
1 5 10 15
Gly Gly Ser Asn Trp Phe Asp Pro
20
<210> 2482
<211> 12
<212> PRT
<213> Homo sapiens
<400> 2482
Ala Ser Ser Ser Trp Leu Arg Gly Ala Phe Asp Ile
1 5 10
<210> 2483
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2483
Ala Ala Pro His Cys Asn Arg Thr Ser Cys Tyr Asp Ala Phe Asp Leu
1 5 10 15
<210> 2484
<211> 19
<212> PRT
<213> Homo sapiens
<400> 2484
Ser Arg Val Arg Gly Ser Phe Tyr Gly Ser Val Gly Lys Asn Tyr Gly
1 5 10 15
Met Asp Val
<210> 2485
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2485
Ala Arg Asp Ile Asp Ser Gly Tyr Asp Pro Thr Pro Val Phe Asp Tyr
1 5 10 15
<210> 2486
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2486
Ala Arg Thr Ser His Tyr Asp Ser Ser Gly Ser Tyr Phe Glu Tyr
1 5 10 15
<210> 2487
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2487
Ala Arg Arg Arg Gly Gly Ile Gly Ile Glu Tyr Gly Met Asp Val
1 5 10 15
<210> 2488
<211> 18
<212> PRT
<213> Homo sapiens
<400> 2488
Ala Lys Asp Phe Gly Gly Asp Asn Thr Ala Met Val Glu Tyr Phe Phe
1 5 10 15
Asp Phe
<210> 2489
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2489
Ala Gly Ser Pro Val Pro Pro Thr Ile Val Gly Ala Ser Tyr
1 5 10
<210> 2490
<211> 13
<212> PRT
<213> Homo sapiens
<400> 2490
Ala Lys Gly Arg Gly Asn Tyr Leu Thr Phe Phe Asp Ser
1 5 10
<210> 2491
<211> 21
<212> PRT
<213> Homo sapiens
<400> 2491
Ala Arg Asp Pro Gly Ser Arg Tyr Ser Gly Gly Trp Tyr Asp Tyr Tyr
1 5 10 15
Tyr Ala Met Asp Val
20
<210> 2492
<211> 9
<212> PRT
<213> Homo sapiens
<400> 2492
Ala Arg Arg Asp Thr Asp Phe Asp Tyr
1 5
<210> 2493
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2493
Ala Ala Pro Tyr Cys Ser Arg Thr Ser Cys His Asp Ala Phe Asp Ile
1 5 10 15
<210> 2494
<211> 18
<212> PRT
<213> Homo sapiens
<400> 2494
Ala Lys Asp Leu Pro Pro Tyr Ala Ser Gly Trp Tyr Glu Gly Gly Phe
1 5 10 15
Asp Tyr
<210> 2495
<211> 13
<212> PRT
<213> Homo sapiens
<400> 2495
Ala Gln Gly Arg Gly Gly Tyr Tyr Ser Pro Phe Asp Asp
1 5 10
<210> 2496
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2496
Ala Arg Thr Thr Trp Gly Thr Trp Ile Gln Ala Trp Tyr Phe Asp Ile
1 5 10 15
<210> 2497
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2497
Ala Arg Glu Gly Asp Phe Trp Ser Gly Tyr Tyr Thr Gly Trp Phe Asp
1 5 10 15
Pro
<210> 2498
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2498
Ala Lys Asp Leu Thr Ile Val Val Ile Pro Ala Ala Pro Asn Phe Asp
1 5 10 15
Tyr
<210> 2499
<211> 22
<212> PRT
<213> Homo sapiens
<400> 2499
Ala Lys Asp Gln Ala Arg Val Gln Asp Tyr Ile Trp Gly Ser Tyr Arg
1 5 10 15
Ser Tyr Gly Met Asp Val
20
<210> 2500
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2500
Ala Lys Asp Ile Ile Arg Gln Gly Glu Asp Gly Met Asp Val
1 5 10
<210> 2501
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2501
Ala Arg Met Arg Ser Gly Trp Pro Thr His Gly Arg Pro Asp Asp Phe
1 5 10 15
<210> 2502
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2502
Ala Arg Trp Leu Gln Leu Arg Ser Asp Tyr Tyr Tyr Phe Gly Met Asp
1 5 10 15
Val
<210> 2503
<211> 12
<212> PRT
<213> Homo sapiens
<400> 2503
Ala Arg Leu Ser Gly Ser Ser Trp Asp Phe Asp Tyr
1 5 10
<210> 2504
<211> 8
<212> PRT
<213> Homo sapiens
<400> 2504
Ala Arg Asp Tyr Arg Asp Trp Ile
1 5
<210> 2505
<211> 21
<212> PRT
<213> Homo sapiens
<400> 2505
Ala His Asn Arg Phe Gln Tyr Cys Ser Ser Thr Thr Cys Tyr Thr Leu
1 5 10 15
Leu Pro Phe Asp Tyr
20
<210> 2506
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2506
Ala Arg Pro Tyr Thr Gly Ser Tyr Lys Ser Tyr Met Asp Val
1 5 10
<210> 2507
<211> 19
<212> PRT
<213> Homo sapiens
<400> 2507
Ala Arg Gly Asp Gly Asp Val Tyr Asn Phe Leu Leu Val Arg Asn Trp
1 5 10 15
Phe Asp Pro
<210> 2508
<211> 13
<212> PRT
<213> Homo sapiens
<400> 2508
Ala Ser Leu Trp Phe Gly Asp Leu Tyr Ser Phe Asp Tyr
1 5 10
<210> 2509
<211> 12
<212> PRT
<213> Homo sapiens
<400> 2509
Ala Arg Leu Gly Arg Ser Ser Trp Asn Phe Asp Tyr
1 5 10
<210> 2510
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2510
Ala Arg Val Gly Gly Ile Ser Pro Tyr Tyr Tyr Tyr Tyr Tyr Met Asp
1 5 10 15
Val
<210> 2511
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2511
Ala Arg Met Arg Ser Gly Trp Pro Thr His Gly Arg Pro Asp Asp Tyr
1 5 10 15
<210> 2512
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2512
Ala Ser Ala Lys Leu Val Ala Thr Ile Ser Tyr Phe Asp Tyr
1 5 10
<210> 2513
<211> 13
<212> PRT
<213> Homo sapiens
<400> 2513
Ala Arg Val Gly Gly Tyr Tyr Tyr Tyr Tyr Met Asp Val
1 5 10
<210> 2514
<211> 8
<212> PRT
<213> Homo sapiens
<400> 2514
Ala Lys Pro Tyr Gly Met Asp Val
1 5
<210> 2515
<211> 24
<212> PRT
<213> Homo sapiens
<400> 2515
Ala Arg Asp Arg Ser Asn Leu Glu Arg Leu Val Met Thr Phe Gly Gly
1 5 10 15
Ile Ile Ala Gly Ala Phe Asp Ile
20
<210> 2516
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2516
Ala Arg Val Asn Ser Gly Ser Tyr Tyr Ser Tyr Phe Asp Tyr
1 5 10
<210> 2517
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2517
Ala Ser Arg Trp Gly Asp Tyr Phe Asp Ser Ser Gly Ala Tyr Asp Ser
1 5 10 15
<210> 2518
<211> 11
<212> PRT
<213> Homo sapiens
<400> 2518
Ala Arg Lys Gly Pro Leu Trp Arg Phe Asp Tyr
1 5 10
<210> 2519
<211> 6
<212> PRT
<213> Homo sapiens
<400> 2519
Ala Arg Glu Ser Thr Gln
1 5
<210> 2520
<211> 19
<212> PRT
<213> Homo sapiens
<400> 2520
Ala Arg Ala Pro Phe Gln Leu Leu Asp Lys Tyr Tyr Phe Phe Tyr Tyr
1 5 10 15
Met Asp Val
<210> 2521
<211> 10
<212> PRT
<213> Homo sapiens
<400> 2521
Ala Arg His Ile Pro Ala Trp Gly Tyr Lys
1 5 10
<210> 2522
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2522
Ala Lys Leu Leu Gly Ser Gly Ile Thr Leu Asp Asn Asp Ala Phe Asp
1 5 10 15
Ile
<210> 2523
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2523
Ala Arg Ile Gly His Phe Asp Ser Ser Gly Tyr Tyr Leu Asp Tyr
1 5 10 15
<210> 2524
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2524
Ala Lys Asp Phe Gly Ser Gly Ile Val Gly Ala Thr Gly Phe Asp Phe
1 5 10 15
<210> 2525
<211> 22
<212> PRT
<213> Homo sapiens
<400> 2525
Ala Arg Arg Arg Ser Ser Ser Arg Tyr Ser Ser Gly Trp Tyr Met Tyr
1 5 10 15
Tyr Tyr Tyr Met Asp Val
20
<210> 2526
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2526
Ala Thr His Arg Cys Ser Gly Gly Phe Cys Tyr Leu Ala Tyr
1 5 10
<210> 2527
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2527
Ala Arg Ala Ser Tyr Asn Ser Asn Trp Ser Ile Gly Glu Tyr Phe Arg
1 5 10 15
Asp
<210> 2528
<211> 20
<212> PRT
<213> Homo sapiens
<400> 2528
Ala Lys Gln Gly Gly Leu Tyr Cys Ser Gly Thr Asn Cys Trp Gly Gly
1 5 10 15
Tyr Leu Asp Tyr
20
<210> 2529
<211> 11
<212> PRT
<213> Homo sapiens
<400> 2529
Val His Arg His Val Ser Gly Ala Phe Asp Tyr
1 5 10
<210> 2530
<211> 24
<212> PRT
<213> Homo sapiens
<400> 2530
Ala Arg Ala Arg Leu Leu Gly Tyr Cys Ser Ser Thr Ser Cys Tyr Thr
1 5 10 15
Ile Gly Trp Gly Ala Phe Asp Ile
20
<210> 2531
<211> 11
<212> PRT
<213> Homo sapiens
<400> 2531
Ala Arg Glu Gly Gln Gly Thr Tyr Leu Asp Tyr
1 5 10
<210> 2532
<211> 19
<212> PRT
<213> Homo sapiens
<400> 2532
Ala Arg Glu Ala Arg Ser Arg Tyr Phe Asp Trp Leu Pro Ser Tyr Tyr
1 5 10 15
Phe Asp Tyr
<210> 2533
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2533
Ala Arg Asp Pro Ser Pro Leu Val Leu Ile Thr Ser Ile Asp Tyr
1 5 10 15
<210> 2534
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2534
Ala Arg Arg Gly Asn Tyr Tyr Asp Ser Lys Asn Trp Phe Asp Pro
1 5 10 15
<210> 2535
<211> 13
<212> PRT
<213> Homo sapiens
<400> 2535
Ala Arg Gly Gly Ser Gly Ser Tyr Ser Leu Phe Asp Tyr
1 5 10
<210> 2536
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2536
Ala Arg Val Leu Tyr Asp Ser Ser Gly Phe Tyr Asn Trp Phe Asp Pro
1 5 10 15
<210> 2537
<211> 18
<212> PRT
<213> Homo sapiens
<400> 2537
Ala Arg Asp Leu Gly Asp Gly Tyr Asn Leu Arg Val Pro Ala Tyr Phe
1 5 10 15
Asp Leu
<210> 2538
<211> 11
<212> PRT
<213> Homo sapiens
<400> 2538
Ala Arg Val Asp His Val Asn Val Arg Asp Tyr
1 5 10
<210> 2539
<211> 21
<212> PRT
<213> Homo sapiens
<400> 2539
Ala Arg Val Asn Gly Asn Ser Asn Trp Asn Phe Gly Ser Tyr Tyr Tyr
1 5 10 15
Tyr Tyr Met Asp Val
20
<210> 2540
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2540
Ala Arg Glu Gly Gln Met Ala Ala Thr Thr Gly Ile Asp Tyr
1 5 10
<210> 2541
<211> 19
<212> PRT
<213> Homo sapiens
<400> 2541
Thr Thr Leu Thr Tyr Tyr Tyr Asp Ser Ser Ala Tyr Leu Asn Asp Ala
1 5 10 15
Phe Asp Ile
<210> 2542
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2542
Ala Lys Gly Ile Tyr Tyr Asp Ile Phe Met Pro Leu Leu Asp
1 5 10
<210> 2543
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2543
Ala Arg Gly Val Val Ala Ala Thr Pro Gly Trp Phe Asp Pro
1 5 10
<210> 2544
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2544
Ala Arg Gly Trp Phe Gly Glu Leu Leu Lys Gly Thr Tyr Trp Phe Asp
1 5 10 15
Pro
<210> 2545
<211> 18
<212> PRT
<213> Homo sapiens
<400> 2545
Ala Arg Val Gly Val Ser Gly Phe Lys Ser Gly Ser Asn Trp Tyr Phe
1 5 10 15
Asp Leu
<210> 2546
<211> 13
<212> PRT
<213> Homo sapiens
<400> 2546
Ala Arg Glu Val Glu Gln Leu Ala His Met Val Asp Tyr
1 5 10
<210> 2547
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2547
Ala Arg Gln Trp Lys Trp Phe Gly Glu Ala Trp Tyr Phe Asp Leu
1 5 10 15
<210> 2548
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2548
Ala Arg Asp Pro Tyr Asp Leu Tyr Gly Asp Tyr Gly Gly Thr Phe Asp
1 5 10 15
Tyr
<210> 2549
<211> 22
<212> PRT
<213> Homo sapiens
<400> 2549
Ala Arg Glu Asp Tyr Tyr Gly Ser Gly Ser Leu Val Asp Pro Tyr Tyr
1 5 10 15
Tyr Tyr Arg Met Asp Val
20
<210> 2550
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2550
Val Arg Asp Leu Ala Leu Phe Glu Val Val Ile Gln Gln Gly Val
1 5 10 15
<210> 2551
<211> 19
<212> PRT
<213> Homo sapiens
<400> 2551
Ala Arg His Thr Val Asp Cys Gly Gly Asp Cys Phe Pro Asn Asp Ala
1 5 10 15
Phe Asp Ile
<210> 2552
<211> 23
<212> PRT
<213> Homo sapiens
<400> 2552
Ala Arg Val Val Val Leu Gly Tyr Gly Arg Pro Asn Asn Tyr Tyr Asp
1 5 10 15
Gly Arg Asn Val Trp Asp Tyr
20
<210> 2553
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2553
Ala Arg Pro Arg Gly Gly Ser Tyr Gln Thr Cys Phe Asp Tyr
1 5 10
<210> 2554
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2554
Ala Arg Trp Gly Pro Asp Tyr Gly Asp Tyr Ala Ser Asn Asp Tyr
1 5 10 15
<210> 2555
<211> 22
<212> PRT
<213> Homo sapiens
<400> 2555
Ala Val Ile Met Ser Pro Ile Pro Arg Tyr Ser Gly Tyr Asp Trp Ala
1 5 10 15
Gly Asp Ala Phe Asp Ile
20
<210> 2556
<211> 10
<212> PRT
<213> Homo sapiens
<400> 2556
Ala Arg Gly Leu Val Gly Arg Ile Asp Pro
1 5 10
<210> 2557
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2557
Ala Arg Asp Gln Gln Ile Val Pro His Ala Asp Gly Phe Asp Ile
1 5 10 15
<210> 2558
<211> 12
<212> PRT
<213> Homo sapiens
<400> 2558
Ala Arg Ile Gly Ser Tyr Pro Glu Tyr Phe Gln His
1 5 10
<210> 2559
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2559
Ala Lys Asp Ile Ile Arg Gln Gly Glu Asp Gly Met Asp Val
1 5 10
<210> 2560
<211> 22
<212> PRT
<213> Homo sapiens
<400> 2560
Ala Arg Asp Val Gly Gly Tyr Ser Gly Tyr Asp Leu Gly Phe Asp Tyr
1 5 10 15
Tyr Tyr Tyr Met Asp Val
20
<210> 2561
<211> 19
<212> PRT
<213> Homo sapiens
<400> 2561
Ala Lys Asp Arg Thr Ala Val Phe Leu Phe Phe Gly Leu Gly Asp Ala
1 5 10 15
Phe Asp Ile
<210> 2562
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2562
Ala Ser Ala Leu Arg Glu Arg Gly Val Gln Leu Trp Ser Val
1 5 10
<210> 2563
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2563
Ala Lys Asp Pro Ala Ser Gly Ile Val Gly Pro Thr His Phe Asp Tyr
1 5 10 15
<210> 2564
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2564
Ala Thr Gly Phe Ala Val Phe Gly Arg Ala Ala Val Pro Tyr
1 5 10
<210> 2565
<211> 19
<212> PRT
<213> Homo sapiens
<400> 2565
Ala Arg Phe Arg Arg Ser Tyr Gly Ser Gly Ser Tyr Tyr Asn Ile Ser
1 5 10 15
Phe Asp Tyr
<210> 2566
<211> 12
<212> PRT
<213> Homo sapiens
<400> 2566
Val Arg Glu Tyr Gly Ser Gly His Pro Leu Pro Ile
1 5 10
<210> 2567
<211> 12
<212> PRT
<213> Homo sapiens
<400> 2567
Ala Arg Ala Thr Trp Leu Arg Asp Ala Phe Gly Ile
1 5 10
<210> 2568
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2568
Ala Arg Gly Phe His Val Pro Ala Ala Leu Arg Asn Trp Phe Asp Pro
1 5 10 15
<210> 2569
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2569
Ala Arg Glu Ala Asn Asp Ser Gly Ser Phe Tyr Asn Gly Pro Phe Asp
1 5 10 15
Tyr
<210> 2570
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2570
Ala Arg Gly Gly Leu Leu Trp Phe Gly Gly Ala Gly Asn Tyr Met Asp
1 5 10 15
Val
<210> 2571
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2571
Ala Arg Met Arg Thr Gly Trp Pro Thr His Gly Arg Pro Asp Asp Phe
1 5 10 15
<210> 2572
<211> 18
<212> PRT
<213> Homo sapiens
<400> 2572
Ala Arg Gly Pro Pro Val Thr Thr Phe Phe Val Phe Ser Leu Leu Phe
1 5 10 15
Asp Pro
<210> 2573
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2573
Ala Lys Glu Gly Glu Trp Glu Leu Arg Gly Asn Ala Leu Asp Ile
1 5 10 15
<210> 2574
<211> 13
<212> PRT
<213> Homo sapiens
<400> 2574
Ala Arg Glu Gly Gln Trp Pro Asn Gln Ala Phe Asp Ile
1 5 10
<210> 2575
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2575
Ala Ser Gly Pro Pro Tyr Met Ala Thr Phe Ser Tyr Tyr Phe Asp Tyr
1 5 10 15
<210> 2576
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2576
Ala Arg Asp Pro Ile Arg Asp Gly Val Trp Gly Leu Asn Glu Asn Asp
1 5 10 15
Tyr
<210> 2577
<211> 18
<212> PRT
<213> Homo sapiens
<400> 2577
Ala Arg Ser Pro Pro Ala Ser Tyr Tyr Asn Pro Ser Thr Gly Tyr Phe
1 5 10 15
Asp Tyr
<210> 2578
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2578
Ala Arg Asp Val Phe Trp Val Pro Ala Ala Ser Ser Phe Asp Tyr
1 5 10 15
<210> 2579
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2579
Ala Arg Asp Gln Glu Trp Phe Arg Glu Leu Phe Leu Phe Asp Tyr
1 5 10 15
<210> 2580
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2580
Ala Arg Met Arg Thr Gly Trp Pro Thr His Gly Arg Pro Asp Asp Phe
1 5 10 15
<210> 2581
<211> 19
<212> PRT
<213> Homo sapiens
<400> 2581
Ala Arg Gly Trp Gly Trp Gly Ala Val Ala Gly Arg Ala Glu Tyr Tyr
1 5 10 15
Phe Asp Tyr
<210> 2582
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2582
Ala Arg Ala Gln Gly Gly Asn Tyr Tyr Tyr Gly Met Asp Val
1 5 10
<210> 2583
<211> 9
<212> PRT
<213> Homo sapiens
<400> 2583
Ala Arg Gly Ala Ala Ser Phe Asp Tyr
1 5
<210> 2584
<211> 18
<212> PRT
<213> Homo sapiens
<400> 2584
Ala Arg Asp Pro Arg Val Val Val Thr Ala Arg Met Tyr Asn Trp Phe
1 5 10 15
Asp Pro
<210> 2585
<211> 18
<212> PRT
<213> Homo sapiens
<400> 2585
Ala Arg Asp Gln Arg Gln Phe Gln Leu Leu Gly Arg Phe Gly Trp Phe
1 5 10 15
Asp Pro
<210> 2586
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2586
Ala Arg Gln Trp Lys Trp Phe Gly Glu Ala Trp Tyr Phe Asp Leu
1 5 10 15
<210> 2587
<211> 18
<212> PRT
<213> Homo sapiens
<400> 2587
Ala Arg Asp Gln Asp Ser Gly Tyr Pro Thr Tyr Tyr Tyr Tyr Tyr Met
1 5 10 15
Asp Val
<210> 2588
<211> 21
<212> PRT
<213> Homo sapiens
<400> 2588
Ala Arg Gly Gly Ile Tyr Tyr Leu Val Arg Gly Phe Ile Ile Gly Tyr
1 5 10 15
Tyr Gly Met Asp Val
20
<210> 2589
<211> 13
<212> PRT
<213> Homo sapiens
<400> 2589
Thr Thr Gly Gly Tyr Ser Ser Tyr Ala Ala Ser Asp Tyr
1 5 10
<210> 2590
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2590
Ala Arg Val Asp Tyr Tyr Gly Ser Gly Ser Val Tyr Trp Tyr Phe Asp
1 5 10 15
Leu
<210> 2591
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2591
Ala Lys Val Gly Trp Glu Leu Ser Ile Asp Ala Phe Asp Leu
1 5 10
<210> 2592
<211> 12
<212> PRT
<213> Homo sapiens
<400> 2592
Ala His Arg Leu Trp Phe Arg Asp Ala Phe Asp Ile
1 5 10
<210> 2593
<211> 12
<212> PRT
<213> Homo sapiens
<400> 2593
Ala Arg Ile Gln Tyr Gln Leu Asn Gly Met Asp Val
1 5 10
<210> 2594
<211> 23
<212> PRT
<213> Homo sapiens
<400> 2594
Ala Arg Gly Arg Val Gly Tyr Val Gly Ser Gly Ser Arg Gly Tyr Tyr
1 5 10 15
Tyr Tyr Tyr Asp Met Asp Val
20
<210> 2595
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2595
Ala Arg Pro Asp Tyr Ser Ser Gly Trp Phe Ser Tyr Trp Tyr Phe Asp
1 5 10 15
Leu
<210> 2596
<211> 12
<212> PRT
<213> Homo sapiens
<400> 2596
Ala Arg Gly Arg Ser Tyr Gly Leu Ser Leu Gly Tyr
1 5 10
<210> 2597
<211> 13
<212> PRT
<213> Homo sapiens
<400> 2597
Ala Arg Glu Ser Ala Asp Ile Ser Ser Arg Leu Asp Tyr
1 5 10
<210> 2598
<211> 12
<212> PRT
<213> Homo sapiens
<400> 2598
Ala His Arg Leu Trp Phe Arg Asp Ala Phe Asp Ile
1 5 10
<210> 2599
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2599
Ala Ser Val Ile Thr Phe Gly Gly Val Ile Val Arg Ser Tyr
1 5 10
<210> 2600
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2600
Ala Arg Val Ser Gly Tyr Gly Asp Tyr Gly Ala Tyr Ser Asp Tyr
1 5 10 15
<210> 2601
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2601
Ala Ser Val Ile Thr Phe Gly Gly Val Ile Val Arg Ser Tyr
1 5 10
<210> 2602
<211> 21
<212> PRT
<213> Homo sapiens
<400> 2602
Ala Arg Val Glu Gly Asp Trp Leu Leu Gly Gly Pro Tyr Tyr His Tyr
1 5 10 15
Tyr Gly Met Asp Val
20
<210> 2603
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2603
Ala Arg Ala Asp Thr Met Val Arg Gly Thr Tyr Phe Glu Tyr
1 5 10
<210> 2604
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2604
Ala Arg Asp Tyr Cys Asn Gly Val Thr Cys Asn Ser Asn Tyr
1 5 10
<210> 2605
<211> 8
<212> PRT
<213> Homo sapiens
<400> 2605
Ala Arg Gly Trp Tyr Phe Asp Tyr
1 5
<210> 2606
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2606
Ala Arg Val Glu Gly Glu Gly Val Asp Ser Tyr Tyr Tyr Gly Met Asp
1 5 10 15
Val
<210> 2607
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2607
Ala Lys Asp Ile Ile Arg Gln Gly Glu Asp Gly Met Asp Val
1 5 10
<210> 2608
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2608
Ala Arg His Pro Val Asp Gly Tyr Asn Tyr Gly Tyr Ser Asp Leu
1 5 10 15
<210> 2609
<211> 23
<212> PRT
<213> Homo sapiens
<400> 2609
Ala Arg Val Val Val Leu Gly Tyr Gly Arg Pro Asn Asn Tyr Tyr Asp
1 5 10 15
Gly Arg Asn Val Trp Asp Tyr
20
<210> 2610
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2610
Ala Arg Ala Gly Gly Gly Ser Tyr Arg Gly Pro Phe Asp Tyr
1 5 10
<210> 2611
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2611
Ala Lys Ser Tyr Asn Gly Asn Tyr Tyr Asp Ala Phe Asp Ile
1 5 10
<210> 2612
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2612
Ala Arg Gly Ser Ala Gly Asn Tyr Tyr Tyr Gly Met Asp Val
1 5 10
<210> 2613
<211> 20
<212> PRT
<213> Homo sapiens
<400> 2613
Ala Arg Leu Thr Phe Gly Gly Ser Gly Ser Tyr Tyr Phe Tyr Tyr Asn
1 5 10 15
Gly Met Asp Val
20
<210> 2614
<211> 19
<212> PRT
<213> Homo sapiens
<400> 2614
Ala Arg Ala Asp Pro Tyr Gln Leu Leu Gly Gln His Tyr Tyr Tyr Gly
1 5 10 15
Met Asp Val
<210> 2615
<211> 20
<212> PRT
<213> Homo sapiens
<400> 2615
Ala Lys Gly Gly Asp Gly Ser Gly Trp Ala Trp Asp Gly Asp Asn Pro
1 5 10 15
Pro Thr Asp Tyr
20
<210> 2616
<211> 18
<212> PRT
<213> Homo sapiens
<400> 2616
Ala Arg Ile Val Leu Gly Ala Ser Gly Thr Tyr Pro Ser Pro Gly Phe
1 5 10 15
Asp Pro
<210> 2617
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2617
Ala Lys Asp Gly Ser Gly Ser Tyr Tyr Gly Trp Phe Asp Pro
1 5 10
<210> 2618
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2618
Ala Arg Ser Cys Gly Asp Cys Tyr Ser Ala Asp Leu Asp Phe
1 5 10
<210> 2619
<211> 12
<212> PRT
<213> Homo sapiens
<400> 2619
Ala Arg Leu Leu Trp Leu Arg Gly His Phe Asp Tyr
1 5 10
<210> 2620
<211> 22
<212> PRT
<213> Homo sapiens
<400> 2620
Ala Val Ile Met Ser Pro Ile Pro Arg Tyr Ser Gly Tyr Asp Trp Ala
1 5 10 15
Gly Gly Ala Phe Asp Ile
20
<210> 2621
<211> 10
<212> PRT
<213> Homo sapiens
<400> 2621
Ala Arg Ala Leu Asn Lys Gly Phe Asp Pro
1 5 10
<210> 2622
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2622
Ala Ala Pro His Cys Asn Arg Thr Ser Cys Tyr Asp Ala Phe Asp Leu
1 5 10 15
<210> 2623
<211> 20
<212> PRT
<213> Homo sapiens
<400> 2623
Ala Arg Asp Arg Leu Gly Asp Gly Ser Tyr Leu Gly Gly Gly Tyr Tyr
1 5 10 15
Gly Met Asp Val
20
<210> 2624
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2624
Ala Arg Met Arg Ser Gly Trp Pro Thr His Gly Arg Pro Asp Asp Leu
1 5 10 15
<210> 2625
<211> 20
<212> PRT
<213> Homo sapiens
<400> 2625
Ala Arg Asp His Ser Gly Tyr Tyr Asp Ser Thr Ser Leu Met Ser Pro
1 5 10 15
Phe Phe Asp Tyr
20
<210> 2626
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2626
Ala Arg Asp Leu Ala Gly Val Pro Ala Ala Leu Gly Cys Trp Phe Asp
1 5 10 15
Pro
<210> 2627
<211> 20
<212> PRT
<213> Homo sapiens
<400> 2627
Ala Lys Asn Leu Gly Pro Tyr Cys Ser Gly Gly Thr Cys Tyr Ser Leu
1 5 10 15
Val Gly Asp Tyr
20
<210> 2628
<211> 13
<212> PRT
<213> Homo sapiens
<400> 2628
Ala Arg Ala Arg Gly Gly Tyr Asn Trp Asn Phe Asp Tyr
1 5 10
<210> 2629
<211> 13
<212> PRT
<213> Homo sapiens
<400> 2629
Ala Arg Asp Gln Gly Thr Val Val Thr His Phe Asp Tyr
1 5 10
<210> 2630
<211> 20
<212> PRT
<213> Homo sapiens
<400> 2630
Ala Lys Asn Leu Gly Pro Tyr Cys Ser Gly Gly Thr Cys Tyr Ser Leu
1 5 10 15
Val Gly Asp Tyr
20
<210> 2631
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2631
Ala Arg Met Arg Ser Gly Trp Pro Thr His Gly Arg Pro Asp Asp His
1 5 10 15
<210> 2632
<211> 20
<212> PRT
<213> Homo sapiens
<400> 2632
Ala Lys Asp Glu Met Ala Tyr Pro Pro Ser His His Tyr Tyr Tyr Tyr
1 5 10 15
Tyr Met Asp Val
20
<210> 2633
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2633
Ala Arg Gly Pro Ser Ile Leu Thr Gly Phe Tyr Asn Pro Leu Asp Tyr
1 5 10 15
<210> 2634
<211> 22
<212> PRT
<213> Homo sapiens
<400> 2634
Ala Arg Arg Thr Tyr Tyr Asp Leu Trp Ser Ala Tyr Ser Ser Thr Ala
1 5 10 15
Tyr Tyr Cys Met Asp Val
20
<210> 2635
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2635
Ala Arg Leu Ser Gly Ser Gly Trp Leu Gly Tyr Ala Met Asp Val
1 5 10 15
<210> 2636
<211> 10
<212> PRT
<213> Homo sapiens
<400> 2636
Ala Arg Pro Ser Asn Trp Tyr Phe Asp Leu
1 5 10
<210> 2637
<211> 20
<212> PRT
<213> Homo sapiens
<400> 2637
Ala Lys Ala Gly Tyr Tyr Ala Tyr Val Trp Gly Ser Tyr Arg Phe Glu
1 5 10 15
Tyr Phe Asp Asn
20
<210> 2638
<211> 11
<212> PRT
<213> Homo sapiens
<400> 2638
Ala Arg Gly Pro Glu Pro Asp Ala Phe Asp Ile
1 5 10
<210> 2639
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2639
Ala Gly Ser Pro Val Pro Pro Thr Ile Val Gly Ala Ser Tyr
1 5 10
<210> 2640
<211> 20
<212> PRT
<213> Homo sapiens
<400> 2640
Ala Arg Asp Leu Ser Thr Thr Trp Tyr Leu Glu Met Trp Gly Pro Asp
1 5 10 15
Ala Phe Asp Ile
20
<210> 2641
<211> 20
<212> PRT
<213> Homo sapiens
<400> 2641
Ala Lys Lys Gly Gly Pro Tyr Cys Gly Gly Gly Asn Cys Tyr Ala Gly
1 5 10 15
Tyr Phe Asp Tyr
20
<210> 2642
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2642
Ala Arg Val Gly Tyr Ser Gln Gly Tyr Tyr Tyr Tyr Tyr Met Asp Val
1 5 10 15
<210> 2643
<211> 20
<212> PRT
<213> Homo sapiens
<400> 2643
Ala Arg Asp Tyr Cys Ser Ser Thr Thr Cys Pro Ala Glu Thr Tyr Tyr
1 5 10 15
Tyr Met Asp Val
20
<210> 2644
<211> 10
<212> PRT
<213> Homo sapiens
<400> 2644
Ala Arg Asp Phe Leu Arg Trp His Asp Leu
1 5 10
<210> 2645
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2645
Ala Arg Val Asp Phe Asp Ile Leu Thr Gly Tyr Tyr Ser Asn
1 5 10
<210> 2646
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2646
Ala Lys Trp Ala Gly Pro Ile Val Met Lys Tyr Tyr Leu Gln Tyr
1 5 10 15
<210> 2647
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2647
Ala Arg Gly Gly Asp Ser Gly Tyr Asp Leu Gly Ala Trp Tyr Phe Asp
1 5 10 15
Leu
<210> 2648
<211> 12
<212> PRT
<213> Homo sapiens
<400> 2648
Ala Arg Thr Pro Thr Leu Tyr Asn Trp Phe His Pro
1 5 10
<210> 2649
<211> 12
<212> PRT
<213> Homo sapiens
<400> 2649
Ala Arg Ala Thr Thr Phe Phe Tyr Gly Met Asp Val
1 5 10
<210> 2650
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2650
Ala Arg His Gln Arg Tyr Cys Ser Ser Ser Ser Cys His Val Trp Asp
1 5 10 15
Tyr
<210> 2651
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2651
Ala Lys Gly Arg Gly Ala Gly Tyr Thr Ser Tyr Met Asp Val
1 5 10
<210> 2652
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2652
Ala Arg Ser Tyr Asp Ile Leu Thr Gly Tyr Arg Asp Ala Phe Asp Ile
1 5 10 15
<210> 2653
<211> 22
<212> PRT
<213> Homo sapiens
<400> 2653
Ala Arg Asp Asp Asn Ser Pro Gln Gly Ser Gly Trp Tyr Phe Tyr Tyr
1 5 10 15
Tyr Tyr Ala Met Asp Val
20
<210> 2654
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2654
Ala Arg Asp Trp Ala Pro Thr Tyr Tyr Asp Met Pro Ser Ala Phe Asp
1 5 10 15
Ile
<210> 2655
<211> 12
<212> PRT
<213> Homo sapiens
<400> 2655
Val Arg Leu Gly Val Ser Ser Trp Tyr Phe Asp Tyr
1 5 10
<210> 2656
<211> 26
<212> PRT
<213> Homo sapiens
<400> 2656
Ala Arg Val Val Val Glu Val Ala Thr Asn Lys Gly Ile His Gly Val
1 5 10 15
Asp Tyr Tyr Tyr Tyr Tyr Tyr Met Asp Val
20 25
<210> 2657
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2657
Ala Arg Leu Arg Tyr Ser Ser Ser Gly Gly His Ile Phe Asp Tyr
1 5 10 15
<210> 2658
<211> 18
<212> PRT
<213> Homo sapiens
<400> 2658
Ala Arg Gly Leu Thr Gly Ser Ser Ala Tyr Lys Asp Glu Ile Tyr Phe
1 5 10 15
Asp Tyr
<210> 2659
<211> 21
<212> PRT
<213> Homo sapiens
<400> 2659
Ala Arg Asp Gly Gly Asn Ala Tyr Ser Ser Gly Trp Tyr Arg Tyr Tyr
1 5 10 15
Tyr His Met Asp Val
20
<210> 2660
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2660
Ala Arg Val Leu Tyr Asp Ser Ser Gly Phe Tyr Asn Trp Phe Asp Pro
1 5 10 15
<210> 2661
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2661
Ala Arg Gly Phe His Val Pro Ala Ala Leu Arg Asn Trp Phe Asp Pro
1 5 10 15
<210> 2662
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2662
Ala Arg Ser Tyr Asp Ile Leu Thr Gly Tyr Arg Asp Ala Phe Asp Ile
1 5 10 15
<210> 2663
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2663
Ala Arg Val Asn Asp Gly Arg Pro Asn Pro Leu Glu Tyr Tyr Phe Asp
1 5 10 15
Tyr
<210> 2664
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2664
Ala Arg Glu Thr Tyr Ser Ala Tyr Glu Met Pro Pro Tyr Phe Asp Tyr
1 5 10 15
<210> 2665
<211> 21
<212> PRT
<213> Homo sapiens
<400> 2665
Ala Arg Asp Leu Ile Ile Glu Ser Thr Ile Ala Ala Arg Pro Gly Tyr
1 5 10 15
Tyr Gly Met Asp Val
20
<210> 2666
<211> 12
<212> PRT
<213> Homo sapiens
<400> 2666
Ala Arg Glu Arg Ser Gly Thr Tyr Phe Phe Asp Tyr
1 5 10
<210> 2667
<211> 11
<212> PRT
<213> Homo sapiens
<400> 2667
Ala Arg Glu Thr Pro Val Thr Ala Ile Asp Tyr
1 5 10
<210> 2668
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2668
Ala Ala Pro Tyr Cys Ser Ser Ile Ser Cys Asn Asp Gly Phe Asp Ile
1 5 10 15
<210> 2669
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2669
Ala Ser Met Thr Arg Met Ser Glu Gln Thr Tyr Tyr Gly Met Asp Val
1 5 10 15
<210> 2670
<211> 8
<212> PRT
<213> Homo sapiens
<400> 2670
Ala Arg Glu Leu Met Ser Val Gly
1 5
<210> 2671
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2671
Ala Arg Asp Ala Leu Tyr Tyr Asn Gly Pro Gly Arg Asp Gly Met Asp
1 5 10 15
Val
<210> 2672
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2672
Ala Arg Asp Ala Leu Tyr Tyr Asn Gly Pro Gly Arg Asp Gly Met Asp
1 5 10 15
Val
<210> 2673
<211> 19
<212> PRT
<213> Homo sapiens
<400> 2673
Ala Lys Asp Met Val Glu Pro Leu Phe Ser His Tyr Tyr Tyr Tyr Gly
1 5 10 15
Met Asp Val
<210> 2674
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2674
Ala Arg Ala Pro Arg Glu Arg Leu Gln Trp Gly Glu Tyr Tyr Phe Asp
1 5 10 15
Tyr
<210> 2675
<211> 22
<212> PRT
<213> Homo sapiens
<400> 2675
Ala Arg Val Phe Glu Thr Lys Val Ile Arg Gly Gly Arg Tyr Tyr Tyr
1 5 10 15
Tyr Tyr Tyr Met Asp Val
20
<210> 2676
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2676
Ala Arg Cys Arg Gln Met Gly Asn Phe Tyr Tyr Tyr Tyr Met Asp Val
1 5 10 15
<210> 2677
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2677
Ala Arg Val Val Pro Thr Arg Gly Pro Val Ala Trp Phe Asp Pro
1 5 10 15
<210> 2678
<211> 21
<212> PRT
<213> Homo sapiens
<400> 2678
Ala Arg Asp Gln Ser Gln Gly Ala Tyr Ile Leu Thr Gly Tyr Arg Gly
1 5 10 15
Tyr Gly Met Asp Val
20
<210> 2679
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2679
Thr Thr Thr Gln Gly Gly Asp Tyr Gly Asp Asn Leu Tyr Tyr Leu Asp
1 5 10 15
Tyr
<210> 2680
<211> 11
<212> PRT
<213> Homo sapiens
<400> 2680
Ala Arg Gly Pro Glu Pro Asp Ala Phe Asp Ile
1 5 10
<210> 2681
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2681
Ala Arg Gly Tyr Gly Phe Val Pro Asn Val Leu Tyr Tyr Phe Asp Tyr
1 5 10 15
<210> 2682
<211> 13
<212> PRT
<213> Homo sapiens
<400> 2682
Ala Arg Gly Gly Ser Ile Leu Trp Trp Leu Ile Asp Tyr
1 5 10
<210> 2683
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2683
Ala Lys Asp Ser Arg Ser Gly Ile Ala Gly Val Asp Ala Phe Asp Ile
1 5 10 15
<210> 2684
<211> 13
<212> PRT
<213> Homo sapiens
<400> 2684
Ala Arg Gly Asp Gly Gly Tyr Tyr Ser Pro Phe Asp Tyr
1 5 10
<210> 2685
<211> 19
<212> PRT
<213> Homo sapiens
<400> 2685
Ala His Arg Leu Pro Thr Pro Gln Leu Leu Pro Ser Phe Glu Asn Trp
1 5 10 15
Phe Asp Pro
<210> 2686
<211> 10
<212> PRT
<213> Homo sapiens
<400> 2686
Ala Arg Glu Val Val Gly Tyr Phe Asp Cys
1 5 10
<210> 2687
<211> 12
<212> PRT
<213> Homo sapiens
<400> 2687
Ala Arg Leu Arg Trp Leu Arg Gly Gly Ile Asp Phe
1 5 10
<210> 2688
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2688
Ala Arg Gly Tyr Gly Phe Val Pro Asn Val Leu Tyr Tyr Phe Asp Tyr
1 5 10 15
<210> 2689
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2689
Ala Arg Ala Gln Gly Gly Asn Tyr Tyr Tyr Gly Met Asp Val
1 5 10
<210> 2690
<211> 25
<212> PRT
<213> Homo sapiens
<400> 2690
Ala Arg Asp Leu Ala Tyr His Pro Tyr Arg Asp Tyr Gly Asp Asp Asp
1 5 10 15
Tyr Tyr Tyr Tyr Tyr Gly Met Asp Val
20 25
<210> 2691
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2691
Ala Arg Gly Ala Ile Pro Pro Asn Ser Arg Ala Glu Ile Asp Tyr
1 5 10 15
<210> 2692
<211> 21
<212> PRT
<213> Homo sapiens
<400> 2692
Ala Arg Glu Asn Asp Tyr Gly Asp Tyr Val Glu Pro Arg Asp Tyr Tyr
1 5 10 15
Tyr Gly Met Asp Val
20
<210> 2693
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2693
Ala Arg Glu Gly Pro Phe Gly Asp Arg Glu Ala Ser Gly Ala Phe Asp
1 5 10 15
Val
<210> 2694
<211> 13
<212> PRT
<213> Homo sapiens
<400> 2694
Thr Gly Val Val Ala Ala Pro Ala Glu Tyr Phe Gln His
1 5 10
<210> 2695
<211> 12
<212> PRT
<213> Homo sapiens
<400> 2695
Ala Arg Leu Gly Phe Tyr Tyr Gly Gly Ala Asp Tyr
1 5 10
<210> 2696
<211> 11
<212> PRT
<213> Homo sapiens
<400> 2696
Ala Lys Asp Gly Ser Ile Ala Ala Ala Asp Tyr
1 5 10
<210> 2697
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2697
Ala Arg Gly Ala Ala Val Pro Ala Ala Gly Glu Phe Asp Tyr
1 5 10
<210> 2698
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2698
Ala Lys Gly Asp Gly Ser Tyr Leu Met Asp Tyr Phe Asp Tyr
1 5 10
<210> 2699
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2699
Ala Arg Ser Tyr Asp Ile Leu Thr Gly Tyr Arg Asp Ala Phe Asp Ile
1 5 10 15
<210> 2700
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2700
Ala Arg Cys Arg Gln Met Gly Asn Phe Tyr Tyr Tyr Tyr Met Asp Val
1 5 10 15
<210> 2701
<211> 18
<212> PRT
<213> Homo sapiens
<400> 2701
Ala Arg Leu Gly Ser Glu Ser Lys Ile Asp Tyr Tyr Tyr Tyr Gly Met
1 5 10 15
Asp Val
<210> 2702
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2702
Ala Arg Gly Arg Gly Tyr Ser Asn Tyr Gly Ala Ser Tyr Tyr Met Asp
1 5 10 15
Val
<210> 2703
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2703
Ala Arg Met Ser Arg Gly Tyr Asn Tyr Ala Tyr Thr Phe Asp Ile
1 5 10 15
<210> 2704
<211> 12
<212> PRT
<213> Homo sapiens
<400> 2704
Ala Arg Thr Met Ala Thr Ile Asn Ala Phe Asp Ile
1 5 10
<210> 2705
<211> 10
<212> PRT
<213> Homo sapiens
<400> 2705
Ala Arg Gly Gly Ala Thr Asn Phe Asp Tyr
1 5 10
<210> 2706
<211> 11
<212> PRT
<213> Homo sapiens
<400> 2706
Ala Arg Pro Gly Lys Ala Ala Ala Phe Asp Tyr
1 5 10
<210> 2707
<211> 21
<212> PRT
<213> Homo sapiens
<400> 2707
Ala Arg Asp Leu His Gln Asp Trp Val Val Val Val Ala Ala Asn Val
1 5 10 15
Tyr Gly Met Asp Val
20
<210> 2708
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2708
Ala Ala Pro Tyr Cys Ser Ser Ile Ser Cys Asn Asp Gly Phe Asp Ile
1 5 10 15
<210> 2709
<211> 12
<212> PRT
<213> Homo sapiens
<400> 2709
Ala Arg Ala Thr Thr Phe Phe Tyr Gly Met Asp Val
1 5 10
<210> 2710
<211> 20
<212> PRT
<213> Homo sapiens
<400> 2710
Ala Lys Lys Gly Gly Pro Tyr Cys Gly Gly Gly Asn Cys Tyr Ala Gly
1 5 10 15
Tyr Phe Asp Tyr
20
<210> 2711
<211> 20
<212> PRT
<213> Homo sapiens
<400> 2711
Ala Lys Leu Asp Val Gly Gly Tyr Asp Phe Val Ser Gly His Tyr Tyr
1 5 10 15
Ala Phe Asp Ile
20
<210> 2712
<211> 21
<212> PRT
<213> Homo sapiens
<400> 2712
Ala Arg Gly Leu Ile Ser Leu Phe Arg Gly Ala Ile Phe His Tyr Tyr
1 5 10 15
Tyr Gly Met Asp Val
20
<210> 2713
<211> 11
<212> PRT
<213> Homo sapiens
<400> 2713
Ala Arg Asp Leu Val Thr Tyr Gly Leu Asp Val
1 5 10
<210> 2714
<211> 19
<212> PRT
<213> Homo sapiens
<400> 2714
Ala His Ser Gly Pro Pro Asp Leu Ser Pro Val Leu Ser Gln Gly Trp
1 5 10 15
Phe Asp Pro
<210> 2715
<211> 22
<212> PRT
<213> Homo sapiens
<400> 2715
Ala Lys Gly Gly Pro Asn Lys Glu Val Leu Tyr Phe Gly Glu Leu Leu
1 5 10 15
Asp Tyr Gly Met Asp Val
20
<210> 2716
<211> 10
<212> PRT
<213> Homo sapiens
<400> 2716
Ala Arg Val Gln Arg Arg Arg Leu Asp Tyr
1 5 10
<210> 2717
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2717
Ala Ala Pro Tyr Cys Ser Ser Ile Ser Cys Asn Asp Gly Phe Asp Ile
1 5 10 15
<210> 2718
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2718
Ala Arg Gly Ala Ile Pro Pro Asn Ser Arg Ala Glu Ile Asp Tyr
1 5 10 15
<210> 2719
<211> 20
<212> PRT
<213> Homo sapiens
<400> 2719
Ala Arg Asp Leu Ser Thr Thr Trp Tyr Leu Glu Met Trp Gly Pro Asp
1 5 10 15
Ala Phe Asp Ile
20
<210> 2720
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2720
Ala Arg Val Leu Tyr Asp Ser Ser Gly Phe Tyr Asn Trp Phe Asp Pro
1 5 10 15
<210> 2721
<211> 20
<212> PRT
<213> Homo sapiens
<400> 2721
Ala Lys Asn Leu Gly Pro Tyr Cys Ser Gly Gly Thr Cys Tyr Ser Leu
1 5 10 15
Val Gly Asp Tyr
20
<210> 2722
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2722
Ala Ala Pro Tyr Cys Ser Ser Ile Ser Cys Asn Asp Gly Phe Asp Ile
1 5 10 15
<210> 2723
<211> 20
<212> PRT
<213> Homo sapiens
<400> 2723
Ala Lys Asp Glu Met Ala Tyr Pro Pro Ser His His Tyr Tyr Tyr Tyr
1 5 10 15
Tyr Met Asp Val
20
<210> 2724
<211> 23
<212> PRT
<213> Homo sapiens
<400> 2724
Ala Arg Leu Val Thr Thr Val Thr Thr Ala Asn Gly Leu Tyr Tyr Tyr
1 5 10 15
Ser Tyr Tyr Tyr Met Asp Val
20
<210> 2725
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2725
Ala Arg Asp Arg Ser Gly Asn Tyr Arg Asp Ala Phe Asp Ile
1 5 10
<210> 2726
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2726
Ala Arg Val Ser Ser Gly Tyr Tyr Phe Thr Pro Phe Asp Tyr
1 5 10
<210> 2727
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2727
Ala Arg Ala Arg Gly Gly Ser Tyr Asn Asp Ala Phe Asp Ile
1 5 10
<210> 2728
<211> 28
<212> PRT
<213> Homo sapiens
<400> 2728
Ala Lys Asp Gly Gln Tyr Tyr Asp Phe Trp Ser Gly Tyr Leu Gly Ala
1 5 10 15
Arg Thr Asn Pro His Tyr Tyr Tyr Tyr Met Asp Val
20 25
<210> 2729
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2729
Ala Lys Asp Met Gly Glu Ala Val Ala Gly Thr His Tyr Gly Met Asp
1 5 10 15
Val
<210> 2730
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2730
Ala Arg Val Gly Ala Tyr Asp Ser Ser Gly Tyr Ser Asn Asp Tyr
1 5 10 15
<210> 2731
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2731
Ala Arg Glu Asp Tyr Tyr Asp Ser Ser Gly Ser Phe Asp Tyr
1 5 10
<210> 2732
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2732
Ala Arg His Ser Gln Gly Trp Leu Gln Gln Ala Val Ala Phe Asp Ile
1 5 10 15
<210> 2733
<211> 21
<212> PRT
<213> Homo sapiens
<400> 2733
Ala Arg Gly Gly Tyr Tyr Tyr Asp Pro Ser Gly Tyr Tyr Ser Arg Ser
1 5 10 15
Phe Ser Phe Asp Tyr
20
<210> 2734
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2734
Ala Arg Asp Leu Val Trp Ala Thr Val Ser Gly Thr Met Asp Val
1 5 10 15
<210> 2735
<211> 22
<212> PRT
<213> Homo sapiens
<400> 2735
Ala Arg Pro Pro Arg Asn Tyr Tyr Asp Arg Ser Gly Tyr Tyr Gln Arg
1 5 10 15
Ala Glu Tyr Phe Gln His
20
<210> 2736
<211> 12
<212> PRT
<213> Homo sapiens
<400> 2736
Ala Arg Val Glu Trp Ala Ala Ala Gly Thr Phe Tyr
1 5 10
<210> 2737
<211> 20
<212> PRT
<213> Homo sapiens
<400> 2737
Ala Arg Trp Lys Ser Asp Tyr Tyr Asp Ser Ser Gly Tyr Tyr Pro Ala
1 5 10 15
Ala Phe Asp Ile
20
<210> 2738
<211> 22
<212> PRT
<213> Homo sapiens
<400> 2738
Ala Gly Asp Gln Asn Leu Tyr Cys Ser Gly Asp Ser Cys Tyr Tyr His
1 5 10 15
Tyr Tyr Gly Met Asp Val
20
<210> 2739
<211> 26
<212> PRT
<213> Homo sapiens
<400> 2739
Ala Arg Asp Ser Glu Tyr Tyr Asp Ile Leu Thr Gly Tyr Leu Ala Pro
1 5 10 15
Thr His Tyr Tyr Tyr Tyr Tyr Met Asp Val
20 25
<210> 2740
<211> 20
<212> PRT
<213> Homo sapiens
<400> 2740
Ala Arg Asp Leu Val Asp Thr Ala Met Val Gln Thr Leu Asp Asp Tyr
1 5 10 15
Gly Met Asp Val
20
<210> 2741
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2741
Ala Arg Tyr Tyr Tyr Asp Ser Arg Gly Tyr Thr Ser Ile Asp Phe
1 5 10 15
<210> 2742
<211> 21
<212> PRT
<213> Homo sapiens
<400> 2742
Ala Arg Leu Asn Tyr Asp Phe Trp Ser Gly Tyr Tyr Ser Tyr Ala Leu
1 5 10 15
Tyr Tyr Met Asp Val
20
<210> 2743
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2743
Ala Arg Gln Gln Leu Asp Tyr Tyr Asp Ser Ser Gly Cys Phe Asp Tyr
1 5 10 15
<210> 2744
<211> 13
<212> PRT
<213> Homo sapiens
<400> 2744
Ala Arg Ala Met Gly Ser Tyr Arg Ser Pro Phe Asp Tyr
1 5 10
<210> 2745
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2745
Ala Arg Gly Gly Asp Arg Tyr Pro Val Gly Tyr Phe Asp Leu
1 5 10
<210> 2746
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2746
Ala Arg Arg Ser Thr Ser Arg Trp Gly Tyr Tyr Tyr Met Asp Val
1 5 10 15
<210> 2747
<211> 18
<212> PRT
<213> Homo sapiens
<400> 2747
Ala Arg Glu Ala Asn Ser Asp Phe Trp Ser Gly Tyr Leu Gly Tyr Phe
1 5 10 15
Asp Tyr
<210> 2748
<211> 12
<212> PRT
<213> Homo sapiens
<400> 2748
Ala Arg Asp Leu Glu Arg Ala Gly Gly Met Asp Val
1 5 10
<210> 2749
<211> 20
<212> PRT
<213> Homo sapiens
<400> 2749
Ala Arg His Met Arg Pro Ser Ile Ala Ala Arg Pro Gly Tyr Gln Tyr
1 5 10 15
Tyr Met Asp Val
20
<210> 2750
<211> 9
<212> PRT
<213> Homo sapiens
<400> 2750
Ala Arg Glu Ala Tyr Gly Met Asp Val
1 5
<210> 2751
<211> 18
<212> PRT
<213> Homo sapiens
<400> 2751
Ala Lys Gly Leu Arg Gly Gln Gln Leu Val Ile Pro Thr Glu Tyr Phe
1 5 10 15
Gln His
<210> 2752
<211> 19
<212> PRT
<213> Homo sapiens
<400> 2752
Ala Arg Gly Pro Arg Gly Cys Ser Ser Thr Ser Cys Tyr Gly Ser Tyr
1 5 10 15
Phe Asp Tyr
<210> 2753
<211> 20
<212> PRT
<213> Homo sapiens
<400> 2753
Ala Arg Asp Gln Pro Leu Pro Asp Ile Leu Thr Gly Tyr Tyr Thr Gly
1 5 10 15
Pro Leu Asp Tyr
20
<210> 2754
<211> 12
<212> PRT
<213> Homo sapiens
<400> 2754
Ala Arg Asp Leu Asp Thr Met Gly Gly Met Asp Val
1 5 10
<210> 2755
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2755
Ala Arg Val Arg Tyr Tyr Asp Ser Ser Gly Tyr Tyr Glu Asp Tyr
1 5 10 15
<210> 2756
<211> 22
<212> PRT
<213> Homo sapiens
<400> 2756
Ala Lys Asp Thr Gly Tyr Cys Gly Asp Asp Cys Tyr Ile Lys Leu Ile
1 5 10 15
Arg Gly Gly Pro Asp Tyr
20
<210> 2757
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2757
Ala Ser Ser Asp Ser Ser Gly Phe Val Gly Ser Arg Gly Phe Asp Tyr
1 5 10 15
<210> 2758
<211> 13
<212> PRT
<213> Homo sapiens
<400> 2758
Ala Ser Phe Gly Asp Asp Ser Gly Asp Glu Gly Val Arg
1 5 10
<210> 2759
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2759
Ala Arg Val Tyr Ser Tyr Asp Ser Ser Gly Tyr Tyr Leu Glu Tyr
1 5 10 15
<210> 2760
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2760
Ala Ser Pro Leu Leu Leu Thr Pro Pro Asp Tyr Tyr Tyr Tyr Met Asp
1 5 10 15
Val
<210> 2761
<211> 20
<212> PRT
<213> Homo sapiens
<400> 2761
Ala Arg Gly Pro Arg Tyr Cys Ser Ser Thr Ser Cys Tyr Ala Gly Val
1 5 10 15
Tyr Phe Asp Tyr
20
<210> 2762
<211> 20
<212> PRT
<213> Homo sapiens
<400> 2762
Ala Arg Asp Gly Phe Gly Asp Val Glu Glu Met Ala Thr Ile Lys Asp
1 5 10 15
Ala Phe Asp Ile
20
<210> 2763
<211> 20
<212> PRT
<213> Homo sapiens
<400> 2763
Ala Arg Pro Asn Pro Ala Gly Gly Tyr Asp Ser Ser Gly Trp Val Asp
1 5 10 15
Ala Phe Asp Ile
20
<210> 2764
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2764
Ala Thr Gly Pro Thr Ile Ala Ala Ala Ala Thr Asn Trp Phe Asp Pro
1 5 10 15
<210> 2765
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2765
Thr Thr Asp Arg Gly Asp Ser Tyr Gly Tyr Tyr Tyr Cys Met Asp Val
1 5 10 15
<210> 2766
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2766
Ala Lys Asp Lys Ala Pro Pro Cys Ser Ser Gly Trp Tyr Tyr Phe Asp
1 5 10 15
Tyr
<210> 2767
<211> 20
<212> PRT
<213> Homo sapiens
<400> 2767
Ala Arg Gly Val Glu Asp Pro Val Val Pro Ala Ala Ile Pro Trp Cys
1 5 10 15
Trp Phe Asp Pro
20
<210> 2768
<211> 18
<212> PRT
<213> Homo sapiens
<400> 2768
Ala Ser Leu Pro Val Val Pro Ala Ala Ile Gly Pro Leu Pro Ala Phe
1 5 10 15
Asp Ile
<210> 2769
<211> 23
<212> PRT
<213> Homo sapiens
<400> 2769
Arg Lys Met Leu Thr Ile Phe Gly Lys Val Asn Gln Thr Met Leu Leu
1 5 10 15
Ile Ser Gly Ala Lys Gly Gln
20
<210> 2770
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2770
Ala Arg Thr His Ser Tyr Asp Asn Ser Gly Gln Tyr Phe Asp Tyr
1 5 10 15
<210> 2771
<211> 20
<212> PRT
<213> Homo sapiens
<400> 2771
Ala Arg Leu Lys Val Ile Thr Ile Phe Gly Val Val Arg Asp Asp Tyr
1 5 10 15
Gly Met Asp Val
20
<210> 2772
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2772
Ala Arg Ser Ala Ser Gly Ser Tyr Tyr Gly Ala Phe Asp Tyr
1 5 10
<210> 2773
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2773
Ala Thr Ser Pro Ala Val Met Ser Val Gly Trp Val Asp Pro
1 5 10
<210> 2774
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2774
Ala Arg Gln Val Arg Gln Trp Leu Glu Asp Asp Ala Phe Asp Ile
1 5 10 15
<210> 2775
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2775
Ala Arg Ala His Val Asp Thr Ala Met Val Glu Ser Gly Ala Phe Asp
1 5 10 15
Ile
<210> 2776
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2776
Ala Gly Arg Tyr Cys Ser Gly Gly Arg Cys Gly Trp Phe Asp Pro
1 5 10 15
<210> 2777
<211> 24
<212> PRT
<213> Homo sapiens
<400> 2777
Ala Arg Val Gln Lys Asp Ile Val Val Val Pro Val Ala Leu Ala Asp
1 5 10 15
Tyr Tyr Tyr Tyr Gly Met Asp Val
20
<210> 2778
<211> 19
<212> PRT
<213> Homo sapiens
<400> 2778
Ala Arg Phe Asp Tyr Gly Tyr Pro Tyr Ser Ser Trp Ser Val Leu Ser
1 5 10 15
Ile Asp Tyr
<210> 2779
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2779
Ala Arg Glu Gly Ser Arg Gln Trp Leu Val Ile Tyr Phe Asp Tyr
1 5 10 15
<210> 2780
<211> 24
<212> PRT
<213> Homo sapiens
<400> 2780
Ala Arg Gly Asp Gly Asp Tyr Tyr Asp Ser Ser Gly Tyr Tyr Arg Pro
1 5 10 15
Thr Leu Tyr Asn Trp Leu Asp Pro
20
<210> 2781
<211> 12
<212> PRT
<213> Homo sapiens
<400> 2781
Ala Arg His Pro Ser Gly Leu Tyr Gln Leu Leu Asn
1 5 10
<210> 2782
<211> 21
<212> PRT
<213> Homo sapiens
<400> 2782
Ala Lys Val Ala Thr Tyr Tyr Tyr Asp Arg Ser Gly Tyr Tyr Tyr Gly
1 5 10 15
Gly Ala Leu Asp Tyr
20
<210> 2783
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2783
Ala Arg Gly Pro Ala Ala Thr Tyr Tyr Tyr Tyr Met Asp Val
1 5 10
<210> 2784
<211> 12
<212> PRT
<213> Homo sapiens
<400> 2784
Ala Lys Glu Ile Ala Val Ala Gly Cys Phe Asp Tyr
1 5 10
<210> 2785
<211> 22
<212> PRT
<213> Homo sapiens
<400> 2785
Ala Arg Val Gly Ser Val Lys Ser Thr Ala Gly Tyr Asp Phe Trp Ser
1 5 10 15
Gly Asp Pro Phe Asp Tyr
20
<210> 2786
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2786
Ala Thr Ala Tyr Ser Val Asp Thr Ala Met Val Arg Gly Val Gly Tyr
1 5 10 15
<210> 2787
<211> 18
<212> PRT
<213> Homo sapiens
<400> 2787
Ala Arg Asp Ala Pro Asp Tyr Tyr Asp Ser Ser Gly Pro Thr Tyr Phe
1 5 10 15
Asp Tyr
<210> 2788
<211> 20
<212> PRT
<213> Homo sapiens
<400> 2788
Ala Lys Met Gly Pro Asp Pro Ala His Asp Tyr Gly Arg Lys Asn Asp
1 5 10 15
Ala Phe Asp Ile
20
<210> 2789
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2789
Ala Lys Ala Glu Pro Glu Val Gly Gly Tyr Asp Tyr Tyr Met Asp Val
1 5 10 15
<210> 2790
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2790
Ala Arg Gly Pro Ala Ala Thr Tyr Tyr Tyr Tyr Met Asp Val
1 5 10
<210> 2791
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2791
Ala Arg Arg Gly Tyr Thr Tyr Gly Ala Asp Phe Tyr Gly Leu Asp Val
1 5 10 15
<210> 2792
<211> 12
<212> PRT
<213> Homo sapiens
<400> 2792
Ala Gly Gly Ser Gly Ile Ser Thr Pro Met Asp Val
1 5 10
<210> 2793
<211> 11
<212> PRT
<213> Homo sapiens
<400> 2793
Ala Arg Asp Leu Ser Glu Gly Gly Met Asp Val
1 5 10
<210> 2794
<211> 18
<212> PRT
<213> Homo sapiens
<400> 2794
Ala Thr Arg Lys Glu Thr Thr Val Thr Thr Ser Leu Val Tyr Gly Met
1 5 10 15
Asp Val
<210> 2795
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2795
Ala Arg Glu Val Met Val Arg Gly Ala Leu Pro Pro Tyr Gly Met Asp
1 5 10 15
Val
<210> 2796
<211> 18
<212> PRT
<213> Homo sapiens
<400> 2796
Ala Arg Gly Pro Phe Tyr Tyr Asp Asn Ser Gly Thr Leu Gly Gly Leu
1 5 10 15
Asp Val
<210> 2797
<211> 12
<212> PRT
<213> Homo sapiens
<400> 2797
Ala Arg Asp Gly Val Ile Pro Pro Arg Phe Asp Tyr
1 5 10
<210> 2798
<211> 18
<212> PRT
<213> Homo sapiens
<400> 2798
Ala Arg Gly Pro Tyr Tyr Tyr Asp Ser Ser Gly Ser Leu Gly Ala Phe
1 5 10 15
Asp Ile
<210> 2799
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2799
Ala Gly Ser Asp Asn Tyr Gly Phe Pro Tyr Asn Gly Met Asp Val
1 5 10 15
<210> 2800
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2800
Ala Arg Asp Ser Arg Phe Ser Tyr Val Asn Gly Glu Phe Asp Tyr
1 5 10 15
<210> 2801
<211> 22
<212> PRT
<213> Homo sapiens
<400> 2801
Ala Arg Val Gly Trp Tyr Asp Phe Gly Thr Pro Gly Asp Tyr Tyr Tyr
1 5 10 15
Tyr Tyr Gly Met Asp Val
20
<210> 2802
<211> 22
<212> PRT
<213> Homo sapiens
<400> 2802
Ala Arg Val Phe Gly Pro Gly Leu Asp Cys Ser Ser Thr Ser Cys Tyr
1 5 10 15
Thr Tyr Gly Met Asp Val
20
<210> 2803
<211> 18
<212> PRT
<213> Homo sapiens
<400> 2803
Val Arg Gly Pro Phe Tyr Tyr Asp Ser Ser Gly Pro Leu Gly Gly Met
1 5 10 15
Asp Val
<210> 2804
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2804
Ala Ala Pro Tyr Cys Ser Ser Thr Asn Cys Tyr Asp Ala Phe Asp Ile
1 5 10 15
<210> 2805
<211> 18
<212> PRT
<213> Homo sapiens
<400> 2805
Ala Lys Asp Phe Leu Trp Asp Leu His Pro Pro Arg Tyr Tyr Gly Met
1 5 10 15
Asp Val
<210> 2806
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2806
Ala Arg Thr Pro Leu Ser Leu Arg Leu Arg Tyr Asn Trp Tyr Phe Asp
1 5 10 15
Leu
<210> 2807
<211> 6
<212> PRT
<213> Homo sapiens
<400> 2807
Ala Arg Gly Phe Asp Tyr
1 5
<210> 2808
<211> 10
<212> PRT
<213> Homo sapiens
<400> 2808
Ala Arg Glu Thr Thr Gly His Phe Asp Tyr
1 5 10
<210> 2809
<211> 13
<212> PRT
<213> Homo sapiens
<400> 2809
Val Arg Gly Gly Val Ser Gly Pro Asn Ser Phe Asp Met
1 5 10
<210> 2810
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2810
Ala Arg Ala Ser Ala Arg Pro Gly Val Ala Thr Asn Leu Asp Phe
1 5 10 15
<210> 2811
<211> 19
<212> PRT
<213> Homo sapiens
<400> 2811
Ala Arg Asp Phe Asn Ser Tyr Gln Leu Leu Trp Tyr Tyr Tyr Tyr Gly
1 5 10 15
Met Asp Val
<210> 2812
<211> 18
<212> PRT
<213> Homo sapiens
<400> 2812
Ala Arg Gln Ser Ser Phe Tyr Ser Ser Gly Trp Tyr Ser Tyr Gly Met
1 5 10 15
Asp Val
<210> 2813
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2813
Ala Arg Val Asp Tyr Gly Ser Gly Ser Tyr Gly Trp Gly Trp Phe Asp
1 5 10 15
Pro
<210> 2814
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2814
Ala Thr Thr Ser Pro Ile Val Gly Ala Ile Thr Trp Phe Asp Pro
1 5 10 15
<210> 2815
<211> 20
<212> PRT
<213> Homo sapiens
<400> 2815
Ala Arg Glu Tyr Tyr Tyr Asp Ser Ser Val Tyr Pro Tyr Tyr Tyr Tyr
1 5 10 15
Ala Met Asp Val
20
<210> 2816
<211> 12
<212> PRT
<213> Homo sapiens
<400> 2816
Ala Arg Val Arg Gly Ser Tyr Tyr Leu Phe Asp Tyr
1 5 10
<210> 2817
<211> 18
<212> PRT
<213> Homo sapiens
<400> 2817
Thr Thr Asp Arg Val Tyr Asp Tyr Ile Trp Gly Ser Tyr Arg Tyr Leu
1 5 10 15
Asp Tyr
<210> 2818
<211> 21
<212> PRT
<213> Homo sapiens
<400> 2818
Ala Arg Asp Arg Glu Ser Tyr Asp Ile Leu Thr Gly Tyr Ser Met Glu
1 5 10 15
Gly Cys Phe Asp Tyr
20
<210> 2819
<211> 19
<212> PRT
<213> Homo sapiens
<400> 2819
Ala Arg Val Trp Gly Tyr Cys Ser Gly Gly Ser Cys Tyr Val Asp Ala
1 5 10 15
Phe Asp Ile
<210> 2820
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2820
Ala Thr Ala Pro Pro Tyr Ser Pro Pro Ser Ser Trp Phe Asp Pro
1 5 10 15
<210> 2821
<211> 22
<212> PRT
<213> Homo sapiens
<400> 2821
Ala Arg Asp His His Tyr Asp Phe Trp Ser Gly Tyr Ser Ser Tyr Tyr
1 5 10 15
Tyr Tyr Gly Met Asp Val
20
<210> 2822
<211> 27
<212> PRT
<213> Homo sapiens
<400> 2822
Ala Arg Asp Glu Ala Tyr Tyr Asp Ile Leu Thr Gly Tyr Ile Asn Ala
1 5 10 15
Pro Lys Asn Tyr Tyr Tyr Tyr Gly Met Asp Val
20 25
<210> 2823
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2823
Ala Arg Ser Phe Gly Gly Ser Tyr Tyr Tyr Gly Met Asp Val
1 5 10
<210> 2824
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2824
Ala Arg Ala Ser Ala Arg Pro Gly Val Ala Thr Asn Leu Asp Phe
1 5 10 15
<210> 2825
<211> 12
<212> PRT
<213> Homo sapiens
<400> 2825
Ala Arg Asp Leu Asp Val Ser Gly Gly Met Asp Val
1 5 10
<210> 2826
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2826
Ala Thr Ala Pro Pro Tyr Ser Pro Pro Ser Ser Trp Phe Asp Pro
1 5 10 15
<210> 2827
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2827
Ala Arg Glu Ala Arg Asp Tyr Tyr Gly Ser Gly Ser Leu Asp Tyr
1 5 10 15
<210> 2828
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2828
Ala Arg Asp Ser Val Ala Gly Ile Tyr Tyr Tyr Tyr Gly Met Asp Val
1 5 10 15
<210> 2829
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2829
Ala Arg Ser Tyr Gly Gly Ser Tyr Tyr Tyr Gly Met Asp Val
1 5 10
<210> 2830
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2830
Ala Arg Thr Pro Leu Ser Leu Arg Leu Arg Tyr Asn Trp Tyr Phe Asp
1 5 10 15
Leu
<210> 2831
<211> 18
<212> PRT
<213> Homo sapiens
<400> 2831
Ala Arg Asp Leu Thr Thr Thr Ala Gly Thr Asp Tyr Tyr Tyr Gly Met
1 5 10 15
Asp Val
<210> 2832
<211> 21
<212> PRT
<213> Homo sapiens
<400> 2832
Ala Arg Ala Arg Val Ala Tyr Asp Tyr Ile Trp Gly Ser Tyr Arg Tyr
1 5 10 15
Lys Ala Phe Asp Tyr
20
<210> 2833
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2833
Ala Arg Ala Gln Thr Ala His Tyr Ser Ser Ser Phe Asp Tyr
1 5 10
<210> 2834
<211> 13
<212> PRT
<213> Homo sapiens
<400> 2834
Ala Arg Gly Gly Arg Leu Ala Asp Ala Ala Gly Asp Tyr
1 5 10
<210> 2835
<211> 10
<212> PRT
<213> Homo sapiens
<400> 2835
Ala Arg Gly His Tyr Asp Leu Phe Asp Tyr
1 5 10
<210> 2836
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2836
Ala Arg Ile Arg Gly Val Tyr Ser Ser Gly Trp Ile Gly Gly Asp Tyr
1 5 10 15
<210> 2837
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2837
Ala Arg Gly Asp Gly Trp Asp Asn Tyr Tyr Tyr Gly Met Asp Val
1 5 10 15
<210> 2838
<211> 11
<212> PRT
<213> Homo sapiens
<400> 2838
Ala Arg Gly Phe Gly Asp Tyr Tyr Phe Asp Tyr
1 5 10
<210> 2839
<211> 13
<212> PRT
<213> Homo sapiens
<400> 2839
Val Arg Gly Gly Val Ser Gly Pro Asn Ala Phe Asp Ile
1 5 10
<210> 2840
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2840
Ala Arg Ser Ile Ser Gly Ser Tyr Leu Gly Ala Phe Asp Tyr
1 5 10
<210> 2841
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2841
Ala Arg Val Gly Leu Trp Trp Leu Gly His Pro Asp Ala Phe Asp Ile
1 5 10 15
<210> 2842
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2842
Ala Arg Thr Lys Gly Gly Ser Tyr Phe Ala Pro Phe Asp Tyr
1 5 10
<210> 2843
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2843
Ala Arg Asp Arg Gly Tyr Ala Ala Thr Phe Gly Val Phe Asp Tyr
1 5 10 15
<210> 2844
<211> 10
<212> PRT
<213> Homo sapiens
<400> 2844
Ala Arg Val Thr Val Val His Phe Asp Tyr
1 5 10
<210> 2845
<211> 20
<212> PRT
<213> Homo sapiens
<400> 2845
Ala Arg Asp Leu Thr Ser Thr Ser Ser Ser Pro Tyr Ser Tyr Tyr Tyr
1 5 10 15
Gly Met Asp Val
20
<210> 2846
<211> 22
<212> PRT
<213> Homo sapiens
<400> 2846
Ala Arg Val Thr Val Glu Ala Ile Phe Gly Val Val Ile Leu Pro Leu
1 5 10 15
Lys Asn Trp Phe Asp Pro
20
<210> 2847
<211> 13
<212> PRT
<213> Homo sapiens
<400> 2847
Val Arg Gly Gly Val Ser Gly Pro Asn Ser Phe Asp Met
1 5 10
<210> 2848
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2848
Ala Arg Val Gly Leu Trp Trp Leu Gly His Pro Asp Val Phe Asp Ile
1 5 10 15
<210> 2849
<211> 18
<212> PRT
<213> Homo sapiens
<400> 2849
Ala Arg Asp Leu Val Glu Asp Thr Ala Met Val Thr Gly Ala Ala Ala
1 5 10 15
Gly Thr
<210> 2850
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2850
Ala Arg Ala Gly Arg Arg Tyr Ser Ser Ser Asp Asp Gly Ala Phe Asp
1 5 10 15
Ile
<210> 2851
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2851
Ala Arg Asp Ile Met Phe Gly Asp Asp Trp Leu Gln Lys Gln Pro Asp
1 5 10 15
Tyr
<210> 2852
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2852
Ala Arg Ser Ile Ser Gly Ser Tyr Leu Gly Ala Phe Asp Tyr
1 5 10
<210> 2853
<211> 25
<212> PRT
<213> Homo sapiens
<400> 2853
Ala Arg Leu Val Pro Thr Trp Ala Ser Tyr Tyr Asp Phe Trp Ser Gly
1 5 10 15
Tyr Pro Gly Gly Tyr Gly Met Asp Val
20 25
<210> 2854
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2854
Ala Thr His Ile Val Val Val Thr Ala Thr Pro Asn Trp Tyr Phe Asp
1 5 10 15
Leu
<210> 2855
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2855
Ala Lys Asp Gly Gly Lys Leu Trp Val Tyr Tyr Phe Asp Tyr
1 5 10
<210> 2856
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2856
Ala Arg Asp Arg Ser Trp Ala Val Val Tyr Tyr Tyr Met Asp Val
1 5 10 15
<210> 2857
<211> 31
<212> PRT
<213> Homo sapiens
<400> 2857
Ala Arg Ala Thr Thr Asp Cys Ser Ser Thr Ser Cys Trp Ser Leu Asp
1 5 10 15
Phe Trp Ser Gly Tyr Tyr Thr Gly Gly Arg Glu Lys Ile Phe Asp
20 25 30
<210> 2858
<211> 11
<212> PRT
<213> Homo sapiens
<400> 2858
Ala Arg Ser Leu Arg Gly Ala Asn Leu Val Pro
1 5 10
<210> 2859
<211> 11
<212> PRT
<213> Homo sapiens
<400> 2859
Ala Arg Ser Leu Arg Gly Ala Asn Leu Val Pro
1 5 10
<210> 2860
<211> 20
<212> PRT
<213> Lama pocos
<400> 2860
Ala Arg Thr Glu Asn Val Arg Ser Leu Leu Ser Asp Tyr Ala Thr Trp
1 5 10 15
Pro Tyr Asp Tyr
20
<210> 2861
<211> 20
<212> PRT
<213> Lama pocos
<400> 2861
Ala Gln Thr His Tyr Val Ser Tyr Leu Leu Ser Asp Tyr Ala Thr Trp
1 5 10 15
Pro Tyr Asp Tyr
20
<210> 2862
<211> 19
<212> PRT
<213> Homo sapiens
<400> 2862
Ala Arg Val Pro Tyr Cys Ser Ser Thr Ser Cys His Arg Asp Trp Tyr
1 5 10 15
Phe Asp Leu
<210> 2863
<211> 19
<212> PRT
<213> Homo sapiens
<400> 2863
Ala Arg Ala Ala Arg Arg Pro Val Val Thr Asp Thr Met Ala Tyr Tyr
1 5 10 15
Met Asp Val
<210> 2864
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2864
Ala Ala Pro His Cys Ser Ser Thr Ile Cys Tyr Asp Gly Phe Asp Ile
1 5 10 15
<210> 2865
<211> 13
<212> PRT
<213> Homo sapiens
<400> 2865
Ala Lys Gly Gly Asp Tyr Glu Trp Glu Leu Leu Glu Ser
1 5 10
<210> 2866
<211> 11
<212> PRT
<213> Homo sapiens
<400> 2866
Ala Arg Asp Phe Gly Asp Phe Phe Phe Asp Tyr
1 5 10
<210> 2867
<211> 11
<212> PRT
<213> Homo sapiens
<400> 2867
Ala Arg Asp Tyr Gly Asp Tyr Phe Phe Asp Tyr
1 5 10
<210> 2868
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2868
Ala Ala Pro Tyr Cys Ser Ser Thr Arg Cys Tyr Asp Ala Phe Asp Ile
1 5 10 15
<210> 2869
<211> 18
<212> PRT
<213> Homo sapiens
<400> 2869
Ala Lys Asp Ile Asn Tyr Asp Ser Gly Gly Tyr His Lys Asn Tyr Phe
1 5 10 15
Asp Tyr
<210> 2870
<211> 18
<212> PRT
<213> Lama pocos
<400> 2870
Ala Ala Ala Glu Trp Gly Tyr Glu Trp Pro Leu Tyr Tyr Ala Ser Ser
1 5 10 15
Trp Tyr
<210> 2871
<211> 18
<212> PRT
<213> Lama pocos
<400> 2871
Ala Ala Ala Tyr Trp Gly Trp Asp Trp Pro Leu Asn Ser Gln Asp Tyr
1 5 10 15
Trp Tyr
<210> 2872
<211> 18
<212> PRT
<213> Lama pocos
<400> 2872
Ala Ala Ala Asp Trp Gly Tyr Asn Trp Pro Leu Ile Arg Glu Glu Tyr
1 5 10 15
Glu Tyr
<210> 2873
<211> 18
<212> PRT
<213> Lama pocos
<400> 2873
Ala Ala Ala Asp Trp Gly Tyr Asn Ile Pro Leu Asn Ile Thr Asp Tyr
1 5 10 15
Trp Tyr
<210> 2874
<211> 18
<212> PRT
<213> Lama pocos
<400> 2874
Ala Ala Ala Met Asn Gly Tyr Asn Glu Pro Leu Tyr Ser Tyr Asp Tyr
1 5 10 15
Glu Tyr
<210> 2875
<211> 18
<212> PRT
<213> Lama pocos
<400> 2875
Ala Ala Ala Ser Trp Gly Tyr Glu Trp Pro Leu Val Tyr Asp Asp Tyr
1 5 10 15
Trp Tyr
<210> 2876
<211> 18
<212> PRT
<213> Lama pocos
<400> 2876
Ala Ala Ala Thr Trp Gly Tyr His Trp Pro Leu Gly Ala Trp Asp Tyr
1 5 10 15
Trp Tyr
<210> 2877
<211> 18
<212> PRT
<213> Lama pocos
<400> 2877
Ala Ala Ala Thr Trp Gly Tyr Ser Trp Pro Leu Glu His Asp Glu Tyr
1 5 10 15
Trp Tyr
<210> 2878
<211> 18
<212> PRT
<213> Lama pocos
<400> 2878
Ala Ala Ala Phe His Gly Glu Gln Tyr Pro Leu Tyr Thr Asn Lys Tyr
1 5 10 15
His Tyr
<210> 2879
<211> 18
<212> PRT
<213> Lama pocos
<400> 2879
Ala Ala Ala Asn Tyr Gly Ala Asn Phe Pro Leu Gln Ala Asn Thr Tyr
1 5 10 15
Phe Tyr
<210> 2880
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2880
Ala Arg Asp Phe Ser Gly His Thr Ala Val Ala Gly Thr Gly Phe Glu
1 5 10 15
Tyr
<210> 2881
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2881
Val Arg Ala Ser Pro Pro Gly Gly Asn Thr Gly Trp Pro Phe Phe Glu
1 5 10 15
Asp
<210> 2882
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2882
Ala Arg Asp Asn Ala Leu Gln Asn Ala Gln Ile Gly Tyr Leu Asp Tyr
1 5 10 15
<210> 2883
<211> 22
<212> PRT
<213> Homo sapiens
<400> 2883
Val Leu Asp Ser Asp Pro Tyr Thr Ala Thr Phe Ser His Asn His Tyr
1 5 10 15
Trp Tyr Ala Met Asp Val
20
<210> 2884
<211> 19
<212> PRT
<213> Homo sapiens
<400> 2884
Ala Arg Asp Pro Ser Ile His Tyr Thr Gly Asn His His Trp Tyr Asp
1 5 10 15
Leu Asp Ile
<210> 2885
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2885
Ala Arg Glu Glu His Tyr Asp Phe Ser Ser Gly Tyr Phe Arg Pro Ala
1 5 10 15
Tyr
<210> 2886
<211> 23
<212> PRT
<213> Homo sapiens
<400> 2886
Ala Arg Gly Met Thr Ser Pro Val Val His Leu Tyr Ser Ser Gly Arg
1 5 10 15
Pro Ser Arg Trp Phe Asp Phe
20
<210> 2887
<211> 21
<212> PRT
<213> Homo sapiens
<400> 2887
Ala Arg Ser Phe Ile Ser Phe Asp Ser Ser Gly His Pro Tyr Tyr Tyr
1 5 10 15
Tyr Ala Met Asp Val
20
<210> 2888
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2888
Ala Arg Asp Asn Ala Leu Gln Asn Ala Gln Ile Gly Tyr Leu Asp Tyr
1 5 10 15
<210> 2889
<211> 19
<212> PRT
<213> Homo sapiens
<400> 2889
Ala Arg Asp Pro Ser Ile Leu Asn Thr Gly Asn His His Trp Tyr Asp
1 5 10 15
Leu Asp Met
<210> 2890
<211> 19
<212> PRT
<213> Homo sapiens
<400> 2890
Ala Arg Asp Pro Thr Phe Leu Asn Ser Gly Asn His Phe Trp Tyr Asp
1 5 10 15
Val Asp Ile
<210> 2891
<211> 19
<212> PRT
<213> Homo sapiens
<400> 2891
Ala Arg Asp Ala Ser Phe Pro Asn Thr Gly Asn His Phe Trp Tyr Asp
1 5 10 15
Phe Asp Leu
<210> 2892
<211> 19
<212> PRT
<213> Homo sapiens
<400> 2892
Ala Lys Lys Gly Ser Pro Tyr Cys Gly Val Asp Cys Tyr Lys Gly Tyr
1 5 10 15
Phe Asp Tyr
<210> 2893
<211> 9
<212> PRT
<213> Homo sapiens
<400> 2893
Ala Arg Val Gly Ser Gly Arg Val Tyr
1 5
<210> 2894
<211> 23
<212> PRT
<213> Homo sapiens
<400> 2894
Ala Arg Val Arg Ile Gly Ala Ser His His Asn Phe Trp Ser Gly Tyr
1 5 10 15
Tyr Thr Asp Ala Phe Asp Ile
20
<210> 2895
<211> 21
<212> PRT
<213> Homo sapiens
<400> 2895
Ala Arg Ala Pro Leu Ala Ser Cys Ser Gly Gly Arg Cys Pro Thr Tyr
1 5 10 15
Asn Arg Phe Asp Leu
20
<210> 2896
<211> 18
<212> PRT
<213> Homo sapiens
<400> 2896
Ala Ser Glu Tyr Phe Asp Gly Arg Ser Tyr His Ser Phe Cys Gly Leu
1 5 10 15
Asp Val
<210> 2897
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2897
Ala Lys Gly Leu Ser Phe Tyr Gly Ser Gly Ser Asp Ala Phe Asp Val
1 5 10 15
<210> 2898
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2898
Ala Arg Asp Leu Ile Ser Val Ile Arg Gly Leu Gly Gly Gly Met Asp
1 5 10 15
Val
<210> 2899
<211> 19
<212> PRT
<213> Homo sapiens
<400> 2899
Ala Arg Gly Gly Pro Leu Pro Trp Ser Asp Leu Asp Ile Val Gly Thr
1 5 10 15
Phe Asp Tyr
<210> 2900
<211> 18
<212> PRT
<213> Homo sapiens
<400> 2900
Val Lys Asp Gln Ser Ser Gly Asp Arg Leu Leu Tyr Leu Gly Tyr Phe
1 5 10 15
Asp Leu
<210> 2901
<211> 18
<212> PRT
<213> Homo sapiens
<400> 2901
Val Lys Asp Gln Ser Ser Gly Asp Arg Leu Leu Tyr Leu Gly Tyr Phe
1 5 10 15
Asp Leu
<210> 2902
<211> 20
<212> PRT
<213> Homo sapiens
<400> 2902
Ala Thr Met Trp Gly Gly Leu Cys Thr Ala Ser Asn Cys Tyr Gly Asn
1 5 10 15
Pro Met Asp Val
20
<210> 2903
<211> 22
<212> PRT
<213> Homo sapiens
<400> 2903
Val Arg Asp Ser Asp Pro Tyr Thr Ala Thr Val Thr Ser Asn His Tyr
1 5 10 15
Trp Tyr Ala Met Asp Val
20
<210> 2904
<211> 22
<212> PRT
<213> Homo sapiens
<400> 2904
Ala Arg Gly Gln Gly Gly Tyr Asp Leu Arg Arg Val Gly Tyr Gly Leu
1 5 10 15
Thr Ser Trp Phe Asp Pro
20
<210> 2905
<211> 20
<212> PRT
<213> Homo sapiens
<400> 2905
Ala Arg Val Leu Ala Gly Ser Ser His Glu Trp Gln Leu Thr His Asp
1 5 10 15
Ala Phe Asp Ile
20
<210> 2906
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2906
Ala Lys Asp Leu Ile Thr Val Ile Arg Gly Leu Gly Gly Gly Met Asp
1 5 10 15
Val
<210> 2907
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2907
Ala Arg Asp Gly Pro Tyr Asp Ser Gly Gly Tyr His Leu Asn His
1 5 10 15
<210> 2908
<211> 13
<212> PRT
<213> Homo sapiens
<400> 2908
Ala Arg Met Gly Pro Tyr Gly Ser Gly Thr Phe Asp Tyr
1 5 10
<210> 2909
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2909
Ala Arg Asp Leu Ser Thr Leu Gln Pro Asp Ala Ile Val Asn Phe Asp
1 5 10 15
Tyr
<210> 2910
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2910
Ala Arg Asp Leu Tyr Tyr Asp Asn Gly Gly Tyr Asn Tyr Leu Asp Tyr
1 5 10 15
<210> 2911
<211> 20
<212> PRT
<213> Homo sapiens
<400> 2911
Val Arg Asp Tyr Cys Asn Ser Val Ser Cys Tyr Thr Tyr Tyr Tyr Ile
1 5 10 15
Gly Met Asp Val
20
<210> 2912
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2912
Ala Thr Ser Ala Ser Ser Tyr Ser Arg Tyr Tyr Phe Gly Leu Asp Val
1 5 10 15
<210> 2913
<211> 18
<212> PRT
<213> Homo sapiens
<400> 2913
Ala Arg Asp Leu Ala Lys Trp Ser Tyr Gly Tyr Tyr Tyr Ser Gly Met
1 5 10 15
Asp Val
<210> 2914
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2914
Ala Arg Glu Glu Tyr Ser Gly Thr Val His Asn Phe Phe Gly Met Asp
1 5 10 15
Val
<210> 2915
<211> 18
<212> PRT
<213> Homo sapiens
<400> 2915
Ala Lys Asp Gly Arg Tyr Cys Ser Gly Ile Ser Cys Arg Thr Gly Met
1 5 10 15
Asp Val
<210> 2916
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2916
Ala Arg Gly Leu Leu Asp Tyr Leu His Asp Ala Phe Asp Ile
1 5 10
<210> 2917
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2917
Ala Ser Arg His Leu Asp Leu Leu Pro Ile Gly Ser Phe Asp Val
1 5 10 15
<210> 2918
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2918
Thr Arg Gly Ser Gly Met Phe Tyr Gly Ser Ser Ser Gly Met Asp Val
1 5 10 15
<210> 2919
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2919
Ala Ile Arg Arg Asp Tyr Ser Asp Tyr Arg Asp Phe Asp Tyr
1 5 10
<210> 2920
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2920
Ala Arg Gln Ser Ser Ser Trp Tyr Asn Pro Tyr Tyr Phe Asp Gln
1 5 10 15
<210> 2921
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2921
Ala Arg Gly Leu Leu Asp Tyr Leu His Asp Ala Phe Asp Ile
1 5 10
<210> 2922
<211> 19
<212> PRT
<213> Homo sapiens
<400> 2922
Ala Arg Asp Pro Ser Ile Leu Asn Thr Gly Asn His His Trp Tyr Asp
1 5 10 15
Leu Asp Leu
<210> 2923
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2923
Ala Arg Pro Arg Ser Gly Ser Tyr Arg Gln Ala Ile Asp Tyr
1 5 10
<210> 2924
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2924
Val Arg Gln Asn Val Ala Ile Gln Tyr Tyr Tyr Tyr Ala Met Asp Val
1 5 10 15
<210> 2925
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2925
Ala Arg Ala Lys Gly Gly Ser Tyr Ser Asn Ala Phe Asp Tyr
1 5 10
<210> 2926
<211> 19
<212> PRT
<213> Homo sapiens
<400> 2926
Ala Arg Asp Pro Ser Ile Leu Asp Thr Gly Asn His His Trp Tyr Asp
1 5 10 15
Leu Asp Ile
<210> 2927
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2927
Ala Arg Glu Glu Tyr Ser Gly Thr Val His Asn Phe Phe Gly Met Asp
1 5 10 15
Val
<210> 2928
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2928
Val Arg Asp Trp Gly Ser Ser Thr His Tyr Asp Val Phe Asp Leu
1 5 10 15
<210> 2929
<211> 19
<212> PRT
<213> Homo sapiens
<400> 2929
Ala Arg Asp Pro Ser Ile Leu Asn Thr Gly Asn His His Trp Tyr Asp
1 5 10 15
Leu Asp Leu
<210> 2930
<211> 19
<212> PRT
<213> Homo sapiens
<400> 2930
Ala Arg Asp Ala Ser Ile Val Gly Thr Gly Asn His Leu Trp Tyr Gly
1 5 10 15
Leu Asp Phe
<210> 2931
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2931
Ala Arg Asp Asn Ala Leu Gln Asp Gly Arg Pro Gly Tyr Phe Asp Ser
1 5 10 15
<210> 2932
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2932
Ala Arg Gly His Arg Phe Leu Glu Phe Pro Leu Asn Tyr Phe Asp Pro
1 5 10 15
<210> 2933
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2933
Ala Arg Asp Asn Ala Leu Gln Asp Gly Arg Pro Gly Tyr Phe Asp Ser
1 5 10 15
<210> 2934
<211> 23
<212> PRT
<213> Homo sapiens
<400> 2934
Ala Leu Leu Tyr Gly Ser Gly Ser Tyr Tyr Asn Phe Val Phe Phe Gly
1 5 10 15
Trp Lys Asp Gly Ser Asp Ala
20
<210> 2935
<211> 19
<212> PRT
<213> Homo sapiens
<400> 2935
Ala Arg Asp Pro Ser Ile Leu Asn Thr Gly Asn His His Trp Tyr Asp
1 5 10 15
Leu Asp Leu
<210> 2936
<211> 19
<212> PRT
<213> Homo sapiens
<400> 2936
Ala Arg Asp Pro Ser Ile His Tyr Thr Gly Asn His His Trp Tyr Asp
1 5 10 15
Leu Asp Ile
<210> 2937
<211> 19
<212> PRT
<213> Homo sapiens
<400> 2937
Ala Arg Asp Pro Ser Ile His Tyr Thr Gly Asn His His Trp Tyr Asp
1 5 10 15
Leu Asp Ile
<210> 2938
<211> 22
<212> PRT
<213> Homo sapiens
<400> 2938
Val Arg Asp Ser Glu Pro Tyr Thr Ala Thr Arg Ser Gln Asn His Tyr
1 5 10 15
Trp Tyr Asp Met Asp Val
20
<210> 2939
<211> 19
<212> PRT
<213> Homo sapiens
<400> 2939
Ala Arg Asp Pro Ser Ile His Tyr Thr Gly Asn His His Trp Tyr Asp
1 5 10 15
Leu Asp Ile
<210> 2940
<211> 19
<212> PRT
<213> Homo sapiens
<400> 2940
Ala Arg Asp Pro Ser Ile Val Asp Ser Gly Pro His His Trp Tyr Asp
1 5 10 15
Leu Asp Ile
<210> 2941
<211> 9
<212> PRT
<213> Homo sapiens
<400> 2941
Ala Ser Gly Pro Asn Tyr Phe Asp Tyr
1 5
<210> 2942
<211> 18
<212> PRT
<213> Homo sapiens
<400> 2942
Ala Arg Ala Asp Arg Asp Tyr Asp Phe Trp Ser Asp Pro Pro Leu Ile
1 5 10 15
Asp His
<210> 2943
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2943
Ala Arg Gly Phe Gly Asn Gly Trp Ser Tyr Tyr Phe Asp Tyr
1 5 10
<210> 2944
<211> 22
<212> PRT
<213> Homo sapiens
<400> 2944
Ala Arg Asp Pro Gly Leu Glu Tyr Ser Gly Asn Tyr Phe Ser Tyr Tyr
1 5 10 15
Tyr Tyr Ala Met Asp Val
20
<210> 2945
<211> 22
<212> PRT
<213> Homo sapiens
<400> 2945
Val Arg Asp Ser Asp Pro Tyr Thr Ala Thr Ser Arg Asn Asn His Tyr
1 5 10 15
Trp Tyr Asp Met Asp Val
20
<210> 2946
<211> 19
<212> PRT
<213> Homo sapiens
<400> 2946
Ala Arg Asp Pro Thr Phe Leu Asn Ser Gly Asn His Phe Trp Tyr Ala
1 5 10 15
Val Asp Ile
<210> 2947
<211> 22
<212> PRT
<213> Homo sapiens
<400> 2947
Val Arg Asp Ser Asp Pro Tyr Thr Ala Thr Tyr Arg Asn Asn His Tyr
1 5 10 15
Trp Tyr Ala Met Asp Val
20
<210> 2948
<211> 13
<212> PRT
<213> Homo sapiens
<400> 2948
Ala Arg Met Gly Pro Ser Gly Ser Gly Ser Leu Asp Tyr
1 5 10
<210> 2949
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2949
Ala His Thr Ser Glu Leu Pro Pro Arg Arg Pro Tyr Ala Ala Phe Asp
1 5 10 15
Phe
<210> 2950
<211> 9
<212> PRT
<213> Homo sapiens
<400> 2950
Ala Arg Asp Leu Pro Pro Leu Asp Tyr
1 5
<210> 2951
<211> 20
<212> PRT
<213> Homo sapiens
<400> 2951
Ala Arg Gly Phe Thr Phe Thr Tyr Ser Asp Phe Leu Thr Gly Gln Arg
1 5 10 15
Thr Phe Glu Tyr
20
<210> 2952
<211> 13
<212> PRT
<213> Homo sapiens
<400> 2952
Ala Arg Ser Tyr Gly Gly Ser Tyr Ser Thr Val Gly Tyr
1 5 10
<210> 2953
<211> 11
<212> PRT
<213> Homo sapiens
<400> 2953
Ser Trp Asn Asp Val Gly Trp Ala Phe Thr Phe
1 5 10
<210> 2954
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2954
Ala Ala Glu Glu Arg Ser Gly Thr Asn His Asn Tyr Tyr Gly Leu Asp
1 5 10 15
Val
<210> 2955
<211> 18
<212> PRT
<213> Homo sapiens
<400> 2955
Ala Arg Asp Arg Glu Met Ala Ile Ile Thr Glu Arg Ser Tyr Gly Leu
1 5 10 15
Asp Val
<210> 2956
<211> 18
<212> PRT
<213> Homo sapiens
<400> 2956
Ala Lys Asp Arg Tyr Cys Ser Gly Gly Ser Cys Phe Tyr Asp Ala Phe
1 5 10 15
Asp Ile
<210> 2957
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2957
Ala Arg Glu Ala Gln Ser Ser Gly Arg Ala Gly Cys Leu Asp Ala
1 5 10 15
<210> 2958
<211> 19
<212> PRT
<213> Homo sapiens
<400> 2958
Ala Arg Asp Pro Ser Ile His Tyr Thr Gly Asn His His Trp Tyr Asp
1 5 10 15
Leu Asp Ile
<210> 2959
<211> 22
<212> PRT
<213> Homo sapiens
<400> 2959
Val Arg Asp Ser Asp Pro Tyr Thr Ala Thr Val Arg Ser Asn His Tyr
1 5 10 15
Trp Tyr Ala Met Asp Val
20
<210> 2960
<211> 19
<212> PRT
<213> Homo sapiens
<400> 2960
Ala Arg Asp Pro Thr Phe Leu Asn Ser Gly Asn His Phe Trp Tyr Ala
1 5 10 15
Val Asp Ile
<210> 2961
<211> 19
<212> PRT
<213> Homo sapiens
<400> 2961
Ala Ala Pro Ala Pro Ser Asn His Glu Ser Trp Ser Gly Thr Asp Trp
1 5 10 15
Phe Asp Pro
<210> 2962
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2962
Ala Arg Thr Thr Pro Arg Gly Trp Glu Gln Trp Pro Val Leu Glu Tyr
1 5 10 15
<210> 2963
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2963
Ala Arg Glu Leu Asp Ser Glu Thr Tyr Tyr Asn Tyr Asn Ser Leu Asp
1 5 10 15
Val
<210> 2964
<211> 21
<212> PRT
<213> Homo sapiens
<400> 2964
Ala Arg Val Val Phe Arg His Gly Gln Tyr Asp Asp Ser Ser Gly Arg
1 5 10 15
Leu Ala Phe Asp Ile
20
<210> 2965
<211> 19
<212> PRT
<213> Homo sapiens
<400> 2965
Ala Arg Asp Pro Ser Ile His Tyr Thr Gly Asn His His Trp Tyr Asp
1 5 10 15
Leu Asp Ile
<210> 2966
<211> 22
<212> PRT
<213> Homo sapiens
<400> 2966
Val Arg Asp Ser Asp Pro Tyr Thr Ala Thr Ser Arg Asn Asn His Tyr
1 5 10 15
Trp Tyr Gly Met Asp Val
20
<210> 2967
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2967
Ala Arg Glu Pro Asp Gly Ile Gly Ala Ala Gly Ile Ser Gly Tyr
1 5 10 15
<210> 2968
<211> 16
<212> PRT
<213> Homo sapiens
<400> 2968
Ala Arg Glu Met Ala Thr Ser Phe Gly Tyr Tyr Phe Val Leu Asp Val
1 5 10 15
<210> 2969
<211> 18
<212> PRT
<213> Homo sapiens
<400> 2969
Ala Arg Gly Gln Glu Ser Pro Ile Val Gly Val Thr Gly Arg Trp Phe
1 5 10 15
Asp Pro
<210> 2970
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2970
Val Arg Pro Tyr Ser Gly Ser Tyr Thr Asn Trp Phe Asp Leu
1 5 10
<210> 2971
<211> 19
<212> PRT
<213> Homo sapiens
<400> 2971
Ala Arg Asp Pro Ser Ile Leu Asn Thr Gly Asn His His Trp Tyr Asp
1 5 10 15
Leu Asp Ile
<210> 2972
<211> 19
<212> PRT
<213> Homo sapiens
<400> 2972
Ala Arg Asp Pro Thr Phe Leu Asn Thr Gly Asn His Phe Trp Tyr Ala
1 5 10 15
Val Asp Ile
<210> 2973
<211> 22
<212> PRT
<213> Homo sapiens
<400> 2973
Val Arg Asp Ser Asp Pro Tyr Thr Ala Thr Ser Arg Asn Asn His Tyr
1 5 10 15
Trp Tyr Ala Met Asp Val
20
<210> 2974
<211> 19
<212> PRT
<213> Homo sapiens
<400> 2974
Ala Arg Asp Pro Ser Phe Leu Asn Thr Gly Asn His Phe Trp Tyr Asp
1 5 10 15
Phe Asp Leu
<210> 2975
<211> 20
<212> PRT
<213> Homo sapiens
<400> 2975
Ala Arg Gly Met Ile Ser Pro Arg Ile Pro Arg Thr Thr Arg Gln Arg
1 5 10 15
Trp Phe Asp Thr
20
<210> 2976
<211> 21
<212> PRT
<213> Homo sapiens
<400> 2976
Ala Arg Gly Lys Ala His Arg Asn Asp Phe Trp Ser Gly Tyr Tyr Pro
1 5 10 15
His Trp Phe Asp Pro
20
<210> 2977
<211> 22
<212> PRT
<213> Homo sapiens
<400> 2977
Ala Arg Asp Ser Asp Pro Tyr Thr Ala Thr Arg Arg His Asn His Tyr
1 5 10 15
Trp Tyr Ala Met Asp Val
20
<210> 2978
<211> 23
<212> PRT
<213> Homo sapiens
<400> 2978
Ala Arg Gly Leu Val Val Arg Tyr Phe Asp Gly Phe Pro Ser Gly Pro
1 5 10 15
Ile Ile Gly Ala Phe Asp Ile
20
<210> 2979
<211> 22
<212> PRT
<213> Homo sapiens
<400> 2979
Val Arg Asp Pro Asp Pro Tyr Thr Ala Thr Val Arg His Asn His Tyr
1 5 10 15
Trp His Gly Met Asp Val
20
<210> 2980
<211> 23
<212> PRT
<213> Homo sapiens
<400> 2980
Ala Arg Gly Ser Leu Ser Arg Glu Tyr Asp Phe Leu Thr Ala Pro Gln
1 5 10 15
Asn Gly Pro Trp Phe Asp Ser
20
<210> 2981
<211> 21
<212> PRT
<213> Homo sapiens
<400> 2981
Ala Arg His Ser Gln Lys Asp Ile Val Leu Ile Pro Ala Ala Gln Ser
1 5 10 15
Pro Ile Phe Asp Tyr
20
<210> 2982
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2982
Val Lys Asp Gly Gly Tyr Tyr Asp Ser Ser Gly Pro Gly His
1 5 10
<210> 2983
<211> 15
<212> PRT
<213> Homo sapiens
<400> 2983
Ala Arg Glu Ser Arg Ser Ser Gly Arg Ala Gly Cys Phe Asp Ser
1 5 10 15
<210> 2984
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2984
Ala Arg Ala Tyr Gly Gly Asn Tyr Gln Asn His Phe Asp His
1 5 10
<210> 2985
<211> 26
<212> PRT
<213> Homo sapiens
<400> 2985
Ala Arg Gly Thr Ile Ser Pro Ile Val Gly Val Pro Thr Pro Val Val
1 5 10 15
Pro Arg Arg Gly Arg Ser Trp Phe Asp Pro
20 25
<210> 2986
<211> 22
<212> PRT
<213> Homo sapiens
<400> 2986
Val Arg Asp Ser Asp Pro Tyr Thr Ala Thr Ser Arg Asn Asn His Tyr
1 5 10 15
Trp Tyr Ala Met Asp Val
20
<210> 2987
<211> 22
<212> PRT
<213> Homo sapiens
<400> 2987
Val Arg Asp Ser Asp Pro Tyr Thr Ala Thr Ser Ser His Asn His Tyr
1 5 10 15
Trp Tyr Ala Met Asp Val
20
<210> 2988
<211> 11
<212> PRT
<213> Homo sapiens
<400> 2988
Ala Arg Asp Arg Gly Ser Gly Val Ile Asp Pro
1 5 10
<210> 2989
<211> 14
<212> PRT
<213> Homo sapiens
<400> 2989
Val Lys Asp Gly Gly Tyr Tyr Asp Ser Ser Gly Pro Gly His
1 5 10
<210> 2990
<211> 20
<212> PRT
<213> Homo sapiens
<400> 2990
Ala Arg Val Gly Trp Val Arg Tyr Phe Asp Trp Ser Lys Pro Tyr Tyr
1 5 10 15
Tyr Phe Asp Leu
20
<210> 2991
<211> 21
<212> PRT
<213> Homo sapiens
<400> 2991
Ala Lys Cys Asp Leu Val Arg Tyr Phe Asp Trp Leu Gly Glu Glu Asn
1 5 10 15
Asn Trp Phe Asp Pro
20
<210> 2992
<211> 22
<212> PRT
<213> Homo sapiens
<400> 2992
Val Arg Asp Ser Asp Pro Tyr Thr Ala Thr Val Arg Asn Asn His Tyr
1 5 10 15
Trp Tyr Ala Leu Asp Val
20
<210> 2993
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2993
Ala Arg Ala Thr Pro Pro Gly Gly Gly Thr Gly Trp Pro Tyr Phe Asp
1 5 10 15
Phe
<210> 2994
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2994
Ala Arg Glu Glu Pro Ser Gly Thr Tyr His Asn Tyr Tyr Gly Leu Asp
1 5 10 15
Val
<210> 2995
<211> 23
<212> PRT
<213> Homo sapiens
<400> 2995
Ala Ala Arg Ile Arg Gly Ala Thr His Tyr Asp Phe Trp Ser Gly Phe
1 5 10 15
Trp Ala Gly Pro Phe Asp Ile
20
<210> 2996
<211> 19
<212> PRT
<213> Homo sapiens
<400> 2996
Ala Arg Thr Gln Ser Asn Asp Phe Trp Ser Gly Tyr Tyr Thr Ala Ala
1 5 10 15
Phe Asp Leu
<210> 2997
<211> 23
<212> PRT
<213> Homo sapiens
<400> 2997
Ala Arg Gly Ser Leu Ser Arg Glu Tyr Asp Phe Leu Thr Ala Pro Gln
1 5 10 15
Asn Gly Pro Trp Phe Asp Ser
20
<210> 2998
<211> 17
<212> PRT
<213> Homo sapiens
<400> 2998
Val Leu Asp Thr Thr Ser Ala Asn Pro His Asn Trp Tyr Gly Met Asp
1 5 10 15
Val
<210> 2999
<211> 13
<212> PRT
<213> Homo sapiens
<400> 2999
Ala Arg Met Gly Pro Tyr Gly Ser Gly Ser Phe Asp Tyr
1 5 10
<210> 3000
<211> 15
<212> PRT
<213> Homo sapiens
<400> 3000
Ala Gly Arg His Gln Glu Leu Leu Pro Met Gly Ser Phe Asp Met
1 5 10 15
<210> 3001
<211> 19
<212> PRT
<213> Homo sapiens
<400> 3001
Ala Arg Asp Pro Ser Ile Leu Asn Thr Gly Asn His His Trp Tyr Asp
1 5 10 15
Leu Asp Ile
<210> 3002
<211> 15
<212> PRT
<213> Homo sapiens
<400> 3002
Val Arg Asp Gly Ala Tyr Asp Ser Ser Gly Tyr Tyr Ser Thr Gln
1 5 10 15
<210> 3003
<211> 19
<212> PRT
<213> Homo sapiens
<400> 3003
Ala Arg Asp Pro Thr Phe Leu Asn Ser Gly Asn His Phe Trp Tyr Ala
1 5 10 15
Val Asp Ile
<210> 3004
<211> 19
<212> PRT
<213> Homo sapiens
<400> 3004
Ala Arg Asp Pro Thr Phe Leu Asn Thr Gly Asn His Phe Trp Tyr Ala
1 5 10 15
Val Asp Ile
<210> 3005
<211> 20
<212> PRT
<213> Homo sapiens
<400> 3005
Ala Arg Asp Phe Gly Val Arg Tyr Asp Asp Ser Arg Gln Leu Met Lys
1 5 10 15
Tyr Cys Asp Ser
20
<210> 3006
<211> 19
<212> PRT
<213> Homo sapiens
<400> 3006
Ala Arg Asp Pro Ser Ile Leu Asn Thr Gly Asn His His Trp Tyr Asp
1 5 10 15
Leu Asp Leu
<210> 3007
<211> 17
<212> PRT
<213> Homo sapiens
<400> 3007
Val Val Asp Thr Thr Met Ala Asp Pro His Asn Trp Tyr Gly Leu Asp
1 5 10 15
Val
<210> 3008
<211> 23
<212> PRT
<213> Homo sapiens
<400> 3008
Ala Arg Val Arg Val Gly Ala Ser His His Asn Phe Trp Ser Gly Tyr
1 5 10 15
Tyr Thr Asp Ala Phe Asp Ile
20
<210> 3009
<211> 19
<212> PRT
<213> Homo sapiens
<400> 3009
Ala Arg Asp Pro Ser Phe Leu Asn Thr Gly Asn His Phe Trp Tyr Asp
1 5 10 15
Phe Asp Met
<210> 3010
<211> 15
<212> PRT
<213> Homo sapiens
<400> 3010
Val Arg Asp Gly Ala Tyr Asp Ser Ser Gly Tyr Tyr Ser Thr Gln
1 5 10 15
<210> 3011
<211> 17
<212> PRT
<213> Homo sapiens
<400> 3011
Ala Arg Asp Phe Pro Gly Asp Thr Ala Val Ala Gly Thr Gly Phe Asn
1 5 10 15
Tyr
<210> 3012
<211> 19
<212> PRT
<213> Homo sapiens
<400> 3012
Ser Arg Asp Leu Arg Arg Gly Tyr Tyr Asp Ser Asn Gly His Gln Gln
1 5 10 15
Phe Asp Leu
<210> 3013
<211> 29
<212> PRT
<213> Homo sapiens
<400> 3013
Ala Arg Asp Pro Gly Pro Ile Thr Phe Phe Asp Trp Ser Pro Asp Lys
1 5 10 15
Ser Arg Lys Ser Tyr Tyr Asp Tyr Asn Gly Met Asp Val
20 25
<210> 3014
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3014
Ala Arg Asp Leu Pro Pro Leu Asp Tyr
1 5
<210> 3015
<211> 22
<212> PRT
<213> Homo sapiens
<400> 3015
Val Arg Asp Ser Asp Pro Tyr Thr Thr Thr Phe Ser His Asn His Tyr
1 5 10 15
Trp Tyr Ala Met Asp Val
20
<210> 3016
<211> 18
<212> PRT
<213> Homo sapiens
<400> 3016
Val Lys Asp Asn Val Ile Leu Pro Gly Ala Ile Val Arg Pro Gln Phe
1 5 10 15
Asp Tyr
<210> 3017
<211> 19
<212> PRT
<213> Homo sapiens
<400> 3017
Ala Arg Asp Pro Ser Ile Leu Asn Thr Gly Asn His His Trp Tyr Asp
1 5 10 15
Leu Asp Met
<210> 3018
<211> 18
<212> PRT
<213> Homo sapiens
<400> 3018
Ala Arg Asp Asn Val Val Gln Gln Asn Ala Asp Asn Val Gly Tyr Phe
1 5 10 15
Asp Phe
<210> 3019
<211> 19
<212> PRT
<213> Homo sapiens
<400> 3019
Ala Arg Asp Pro Ser Ile Leu Asn Thr Gly Asn His His Trp Tyr Asp
1 5 10 15
Leu Asp Leu
<210> 3020
<211> 22
<212> PRT
<213> Homo sapiens
<400> 3020
Val Arg Asp Ser Asp Pro Tyr Thr Ala Thr Ser Arg Asn Asn His Tyr
1 5 10 15
Trp Tyr Gly Met Asp Val
20
<210> 3021
<211> 19
<212> PRT
<213> Homo sapiens
<400> 3021
Ala Arg Asp Pro Ser Ile Leu Asn Thr Gly Asn His His Trp Tyr Asp
1 5 10 15
Leu Asp Met
<210> 3022
<211> 17
<212> PRT
<213> Homo sapiens
<400> 3022
Ala Arg Glu Gly Thr Ser Leu Gly Tyr Tyr Tyr Tyr Tyr Ala Met Asp
1 5 10 15
Val
<210> 3023
<211> 19
<212> PRT
<213> Homo sapiens
<400> 3023
Ala Arg Asp Pro Ser Ile Leu Asn Thr Gly Asn His His Trp Tyr Asp
1 5 10 15
Leu Asp Met
<210> 3024
<211> 15
<212> PRT
<213> Homo sapiens
<400> 3024
Ala Arg Gly Pro Ile Arg His Phe Gly Leu Asp Ala Phe Asp Ile
1 5 10 15
<210> 3025
<211> 22
<212> PRT
<213> Homo sapiens
<400> 3025
Val Arg Asp Ser Asp Pro Tyr Thr Ala Thr Ser Arg Asn Asn His Tyr
1 5 10 15
Trp Tyr Gly Met Asp Val
20
<210> 3026
<211> 19
<212> PRT
<213> Homo sapiens
<400> 3026
Ala Arg Asp Pro Ser Ile Leu Asn Thr Gly Asn His His Trp Tyr Asp
1 5 10 15
Leu Asp Met
<210> 3027
<211> 15
<212> PRT
<213> Homo sapiens
<400> 3027
Val Lys Asp Leu Gly Ala Thr Val Thr Tyr Asp Val Phe Asp Val
1 5 10 15
<210> 3028
<211> 15
<212> PRT
<213> Homo sapiens
<400> 3028
Ala Lys Glu Arg Asp Leu Pro Gly Arg Gly Gly Tyr Phe Asp His
1 5 10 15
<210> 3029
<211> 23
<212> PRT
<213> Homo sapiens
<400> 3029
Ala Arg Gly Tyr Thr Ala Pro Ile Ile Arg Glu Val Pro Ile Thr Phe
1 5 10 15
Arg Pro Arg Trp Phe Asp Pro
20
<210> 3030
<211> 13
<212> PRT
<213> Homo sapiens
<400> 3030
Ala Arg Met Gly Pro Tyr Gly Ser Gly Thr Phe Asp Tyr
1 5 10
<210> 3031
<211> 16
<212> PRT
<213> Homo sapiens
<400> 3031
Ala Arg Asp His Ala Leu Gln Asn Gly Arg Pro Gly Tyr Phe Asp Ser
1 5 10 15
<210> 3032
<211> 14
<212> PRT
<213> Homo sapiens
<400> 3032
Val Arg Glu Gly Gln Gln Trp Leu Gly Leu Tyr Phe Asp His
1 5 10
<210> 3033
<211> 18
<212> PRT
<213> Homo sapiens
<400> 3033
Ala Arg Glu Lys Lys Ser Phe Gly Pro Gln Tyr Tyr Tyr Gly Ser Gly
1 5 10 15
Glu Asp
<210> 3034
<211> 20
<212> PRT
<213> Homo sapiens
<400> 3034
Val Arg Gln Arg Tyr Cys Ser Gly Gly Ser Cys Phe Leu Phe Glu Asp
1 5 10 15
Ala Phe Glu Ile
20
<210> 3035
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3035
Val Arg Asp Thr Asp Trp Ala Phe Asp Ser
1 5 10
<210> 3036
<211> 17
<212> PRT
<213> Homo sapiens
<400> 3036
Ala His Thr Ser Glu Leu Pro Pro Arg Arg Pro Tyr Ala Ala Phe Asp
1 5 10 15
Phe
<210> 3037
<211> 8
<212> PRT
<213> Homo sapiens
<400> 3037
Ala Asn Thr Asn Phe Leu Asp Tyr
1 5
<210> 3038
<211> 21
<212> PRT
<213> Homo sapiens
<400> 3038
Thr Arg Ser Phe Ile Ser Phe Asp Ser Ser Gly His Pro Tyr Tyr Tyr
1 5 10 15
Tyr Ala Met Asp Val
20
<210> 3039
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3039
Thr Arg Glu Thr Gly Thr Asp Glu Phe Asp Phe
1 5 10
<210> 3040
<211> 20
<212> PRT
<213> Homo sapiens
<400> 3040
Ala Thr Met Trp Gly Gly Leu Cys Thr Ala Ser Asn Cys Tyr Gly Asn
1 5 10 15
Pro Met Asp Val
20
<210> 3041
<211> 20
<212> PRT
<213> Homo sapiens
<400> 3041
Ala Thr Met Trp Gly Gly Leu Cys Thr Ala Ser Asn Cys Tyr Gly Asn
1 5 10 15
Pro Met Asp Val
20
<210> 3042
<211> 20
<212> PRT
<213> Homo sapiens
<400> 3042
Ala Thr Met Trp Gly Gly Leu Cys Thr Ala Ser Asn Cys Tyr Gly Asn
1 5 10 15
Pro Met Asp Val
20
<210> 3043
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3043
Ala Arg Asp Leu Ala Trp Thr Phe Phe Asp Tyr
1 5 10
<210> 3044
<211> 17
<212> PRT
<213> Homo sapiens
<400> 3044
Ala Arg Ala Thr Pro Pro Gly Gly Thr Thr Gly Trp Pro Tyr Ile Asp
1 5 10 15
Leu
<210> 3045
<211> 8
<212> PRT
<213> Homo sapiens
<400> 3045
Ala Asn Thr Asn Phe Leu Asp Tyr
1 5
<210> 3046
<211> 13
<212> PRT
<213> Homo sapiens
<400> 3046
Ala Lys Leu Gly Thr Asp His Pro Ile Gly Val Asp Val
1 5 10
<210> 3047
<211> 14
<212> PRT
<213> Homo sapiens
<400> 3047
Val Lys Ala Leu Tyr Ser Ser Ser Trp Cys Pro Phe Asp Tyr
1 5 10
<210> 3048
<211> 17
<212> PRT
<213> Homo sapiens
<400> 3048
Ala Arg Glu Leu Asp Ser Glu Thr Tyr Tyr Asn Tyr Asn Ser Leu Asp
1 5 10 15
Val
<210> 3049
<211> 17
<212> PRT
<213> Homo sapiens
<400> 3049
Ala Lys Ala Gln Gly Ile Tyr Tyr Arg Gly Trp Ser Tyr Trp Phe Asp
1 5 10 15
Pro
<210> 3050
<211> 24
<212> PRT
<213> Homo sapiens
<400> 3050
Ala Arg Glu Ala Arg Arg Gln Val Thr Gln Trp Phe Gly Glu Phe Trp
1 5 10 15
Gly Pro Tyr Asn Trp Phe Asp Pro
20
<210> 3051
<211> 18
<212> PRT
<213> Homo sapiens
<400> 3051
Ala Arg Gly Leu Ile Ser Tyr Thr Leu Trp Leu Arg Glu Ser Tyr Phe
1 5 10 15
Asp Tyr
<210> 3052
<211> 19
<212> PRT
<213> Homo sapiens
<400> 3052
Ala Arg Asp Pro Ser Ile Leu Asn Thr Gly Asn His His Trp Tyr Asp
1 5 10 15
Leu Asp Ile
<210> 3053
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3053
Ala Arg Asp Tyr Gly Asp Gly Pro Pro Asp His
1 5 10
<210> 3054
<211> 17
<212> PRT
<213> Homo sapiens
<400> 3054
Val Leu Asp Thr Thr Met Ser His Pro His Asn Trp Tyr Gly Met Asp
1 5 10 15
Val
<210> 3055
<211> 18
<212> PRT
<213> Homo sapiens
<400> 3055
Ala Ser Glu Tyr Phe Asp Gly Arg Ser Tyr His Ser Phe Cys Gly Leu
1 5 10 15
Asp Val
<210> 3056
<211> 19
<212> PRT
<213> Homo sapiens
<400> 3056
Ala Arg Asp Pro Ser Ile Leu Asn Thr Gly Pro His His Trp Tyr Asp
1 5 10 15
Leu Asp Ile
<210> 3057
<211> 22
<212> PRT
<213> Homo sapiens
<400> 3057
Val Arg Asp Ser Glu Pro Tyr Thr Ala Thr Arg Ser Gln Asn His Tyr
1 5 10 15
Trp Tyr Asp Met Asp Val
20
<210> 3058
<211> 19
<212> PRT
<213> Homo sapiens
<400> 3058
Ala Arg Glu Phe Gly Val Arg Phe Leu Asp Arg Ser Leu Phe Gly Ala
1 5 10 15
Met Asp Val
<210> 3059
<211> 12
<212> PRT
<213> Homo sapiens
<400> 3059
Ala Arg Ala Gly Gly Tyr Leu Ser Ala Phe Asp Ile
1 5 10
<210> 3060
<211> 19
<212> PRT
<213> Homo sapiens
<400> 3060
Ala Arg Asp Pro Ser Phe Leu Asn Ala Gly Asn His Phe Tyr Tyr Asp
1 5 10 15
Phe Asp Val
<210> 3061
<211> 18
<212> PRT
<213> Homo sapiens
<400> 3061
Ala Arg Ala Gly Asn Ile Val Val Met Pro Ala Ala Gln Tyr Tyr Phe
1 5 10 15
Asp Tyr
<210> 3062
<211> 19
<212> PRT
<213> Homo sapiens
<400> 3062
Val Arg Asp Asp Val Leu Gln His Ser Arg Pro Ser Gly Pro Gly Tyr
1 5 10 15
Phe Val Ser
<210> 3063
<211> 19
<212> PRT
<213> Homo sapiens
<400> 3063
Ala Arg Gly Ser Gln Ile Asp Leu Arg Gly Gly Leu Gly Ala Thr Phe
1 5 10 15
Phe Asp Tyr
<210> 3064
<211> 22
<212> PRT
<213> Homo sapiens
<400> 3064
Ala Arg Asp Ser Asp Pro Tyr Thr Ala Thr Arg Arg His Asn His Tyr
1 5 10 15
Trp Tyr Ala Met Asp Val
20
<210> 3065
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3065
Val Arg Asp Thr Asp Trp Ala Phe Asp Ser
1 5 10
<210> 3066
<211> 17
<212> PRT
<213> Homo sapiens
<400> 3066
Ala Arg Arg Gly Asn Asn Phe Gly Tyr Tyr Tyr Tyr Tyr Thr Val Asp
1 5 10 15
Val
<210> 3067
<211> 20
<212> PRT
<213> Homo sapiens
<400> 3067
Ala Arg Val Leu Ala Gly Ser Ser His Glu Trp Gln Leu Thr His Asp
1 5 10 15
Ala Phe Asp Ile
20
<210> 3068
<211> 20
<212> PRT
<213> Homo sapiens
<400> 3068
Ala Lys Gly Asp Trp Ile Arg Tyr Phe Asp Trp Ser Leu Pro Ile Ser
1 5 10 15
Phe Phe Asp Tyr
20
<210> 3069
<211> 18
<212> PRT
<213> Homo sapiens
<400> 3069
Ala Arg Thr Thr Ser Pro Leu Thr Tyr Ser Gly His Trp Pro Leu Phe
1 5 10 15
Asp Tyr
<210> 3070
<211> 22
<212> PRT
<213> Homo sapiens
<400> 3070
Val Arg Asp Ser Asp Pro Tyr Thr Ala Thr Ser Arg Asn Asn His Tyr
1 5 10 15
Trp Tyr Gly Met Asp Val
20
<210> 3071
<211> 19
<212> PRT
<213> Homo sapiens
<400> 3071
Ala Arg Asp Pro Ser Ile Leu Asn Thr Gly Asn His His Trp Tyr Asp
1 5 10 15
Leu Asp Ile
<210> 3072
<211> 19
<212> PRT
<213> Homo sapiens
<400> 3072
Ala Arg Asp Pro Ser Ile Leu Asn Thr Gly Asn His His Trp Tyr Asp
1 5 10 15
Leu Asp Ile
<210> 3073
<211> 15
<212> PRT
<213> Homo sapiens
<400> 3073
Val Arg Met Asp Trp Met Glu Trp Met Lys Tyr Tyr Phe Asp Ser
1 5 10 15
<210> 3074
<211> 19
<212> PRT
<213> Homo sapiens
<400> 3074
Ala Arg Asp Pro Ser Ile Leu Asn Thr Gly Asn His His Trp Tyr Asp
1 5 10 15
Leu Asp Met
<210> 3075
<211> 19
<212> PRT
<213> Homo sapiens
<400> 3075
Val Arg Asp Asp Val Leu Gln His Ser Arg Pro Ser Gly Pro Gly Tyr
1 5 10 15
Phe Val Ser
<210> 3076
<211> 20
<212> PRT
<213> Homo sapiens
<400> 3076
Ala Thr Met Trp Gly Gly Leu Cys Thr Ala Ser Asn Cys Tyr Gly Asn
1 5 10 15
Pro Met Asp Val
20
<210> 3077
<211> 7
<212> PRT
<213> Mus musculus
<400> 3077
Thr Arg Ser Ala Met Asp Tyr
1 5
<210> 3078
<211> 4
<212> PRT
<213> Mus musculus
<400> 3078
Ala Leu Arg Arg
1
<210> 3079
<211> 4
<212> PRT
<213> Mus musculus
<400> 3079
Ala Leu Arg Arg
1
<210> 3080
<211> 4
<212> PRT
<213> Mus musculus
<400> 3080
Ala Leu Arg Arg
1
<210> 3081
<211> 13
<212> PRT
<213> Mus musculus
<400> 3081
Ala Arg Ile Tyr Asp Phe Asp Glu Asp Tyr Phe Asp Val
1 5 10
<210> 3082
<211> 15
<212> PRT
<213> Homo sapiens
<400> 3082
Val Lys Asp Gln Asp Ser Ser Ser Trp Tyr Asp Ala Phe Asp Ile
1 5 10 15
<210> 3083
<211> 15
<212> PRT
<213> Homo sapiens
<400> 3083
Val Lys Asp Gln Asp Ser Ser Ser Trp Tyr Asp Ala Phe Asp Ile
1 5 10 15
<210> 3084
<211> 12
<212> PRT
<213> Homo sapiens
<400> 3084
Ala Arg Asp Leu Ser Val Arg Gly Gly Met Asp Val
1 5 10
<210> 3085
<211> 15
<212> PRT
<213> Homo sapiens
<400> 3085
Ala Lys Asp Leu Val Thr Ala Pro Ser Tyr Glu Ala Phe Asp Ile
1 5 10 15
<210> 3086
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3086
Ala Arg Asp Leu Gln Tyr Tyr Gly Met Asp Val
1 5 10
<210> 3087
<211> 15
<212> PRT
<213> Homo sapiens
<400> 3087
Val Lys Asp Gln Asp Ser Asn Ser Trp Tyr Asp Ala Phe Asp Ile
1 5 10 15
<210> 3088
<211> 12
<212> PRT
<213> Homo sapiens
<400> 3088
Ala Arg Asp Leu Ala Val Ala Gly Ala Phe Asp Ile
1 5 10
<210> 3089
<211> 12
<212> PRT
<213> Homo sapiens
<400> 3089
Ala Arg Asp Leu Ser Val Arg Gly Gly Met Asp Val
1 5 10
<210> 3090
<211> 13
<212> PRT
<213> Homo sapiens
<400> 3090
Ala Leu Ala Ser Gly Ser Tyr Phe Gly Gly Ala Asn Tyr
1 5 10
<210> 3091
<211> 13
<212> PRT
<213> Homo sapiens
<400> 3091
Ala Thr Gly Ala Arg Phe Gly Glu Ser Pro Phe Asp Tyr
1 5 10
<210> 3092
<211> 13
<212> PRT
<213> Homo sapiens
<400> 3092
Ala Thr Gly Ala Arg Phe Gly Glu Ser Pro Phe Asp Tyr
1 5 10
<210> 3093
<211> 23
<212> PRT
<213> Homo sapiens
<400> 3093
Ala Arg Glu Gly Gly Leu Asp Tyr Phe Gly Ser Arg Asn Ser Gly Trp
1 5 10 15
Thr Tyr Thr Trp Phe Asp Pro
20
<210> 3094
<211> 20
<212> PRT
<213> Homo sapiens
<400> 3094
Ala Arg Gly Val Asn Tyr Tyr Asp Arg Asn Gly Tyr Tyr Arg Asn Asp
1 5 10 15
Gly Phe Asp Ile
20
<210> 3095
<211> 15
<212> PRT
<213> Homo sapiens
<400> 3095
Ala Ser Ser Lys Gly Phe Cys Ser Gly Gly Ser Cys Ser Asp Tyr
1 5 10 15
<210> 3096
<211> 17
<212> PRT
<213> Homo sapiens
<400> 3096
Ala Lys Asp Leu Arg Arg Gln Asp Tyr Tyr Ala Asp Trp Tyr Phe Asp
1 5 10 15
Leu
<210> 3097
<211> 20
<212> PRT
<213> Homo sapiens
<400> 3097
Ala Arg Gly Val Asn Tyr Tyr Asp Arg Asn Gly Tyr Tyr Arg Asn Asp
1 5 10 15
Gly Phe Asp Ile
20
<210> 3098
<211> 17
<212> PRT
<213> Homo sapiens
<400> 3098
Ala Lys Asp Leu Arg Arg Gln Asp Tyr Tyr Ala Asp Trp Tyr Phe Asp
1 5 10 15
Leu
<210> 3099
<211> 20
<212> PRT
<213> Homo sapiens
<400> 3099
Ala Arg Gly Val Asn Tyr Tyr Asp Arg Asn Gly Tyr Tyr Arg Asn Asp
1 5 10 15
Gly Phe Asp Ile
20
<210> 3100
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3100
Ala Lys Ile Gly Ser Arg Asn Ser Leu Gly Val
1 5 10
<210> 3101
<211> 16
<212> PRT
<213> Homo sapiens
<400> 3101
Ala Ala Pro Arg Cys Ser Gly Gly Ser Cys Tyr Asp Gly Phe Asp Ile
1 5 10 15
<210> 3102
<211> 14
<212> PRT
<213> Lama pocos
<400> 3102
Asn Val Lys Asp Glu Gly Ala Thr Thr Lys Val Tyr Asp Tyr
1 5 10
<210> 3103
<211> 14
<212> PRT
<213> Lama pocos
<400> 3103
Asn Val Lys Asp Trp Gly Ala Ala Asn Lys Tyr Tyr Asp Tyr
1 5 10
<210> 3104
<211> 14
<212> PRT
<213> Lama pocos
<400> 3104
Asn Val Lys Asp Asp Gly Gln Leu Ala Tyr His Tyr Asp Tyr
1 5 10
<210> 3105
<211> 14
<212> PRT
<213> Lama pocos
<400> 3105
Asn Val Lys Asp Asp Gly Gln Leu Ala Tyr His Tyr Asp Tyr
1 5 10
<210> 3106
<211> 14
<212> PRT
<213> Lama pocos
<400> 3106
Asn Val Trp Asp Asp Gly Gln Leu Ala Tyr His Tyr Asp Tyr
1 5 10
<210> 3107
<211> 14
<212> PRT
<213> Lama pocos
<400> 3107
Asn Val Tyr Asp Asp Gly Gln Leu Ala Tyr His Tyr Asp Tyr
1 5 10
<210> 3108
<211> 14
<212> PRT
<213> Lama pocos
<400> 3108
Asn Val Lys Asp Tyr Gly Trp Tyr Asn Ser Gln Tyr Asp Tyr
1 5 10
<210> 3109
<211> 14
<212> PRT
<213> Lama pocos
<400> 3109
Asn Val Lys Asp Tyr Gly Ala Ala Ser Trp Glu Tyr Asp Tyr
1 5 10
<210> 3110
<211> 14
<212> PRT
<213> Lama pocos
<400> 3110
Asn Val Lys Asp Phe Gly Gly His Gln Ala Tyr Tyr Asp Tyr
1 5 10
<210> 3111
<211> 14
<212> PRT
<213> Lama pocos
<400> 3111
Asn Val Lys Asp Glu Gly Asp Thr Ser Ala Ser Tyr Asp Tyr
1 5 10
<210> 3112
<211> 14
<212> PRT
<213> Lama pocos
<400> 3112
Asn Val Lys Asp Glu Gly Tyr Phe Ser Asp Glu Tyr Asp Tyr
1 5 10
<210> 3113
<211> 14
<212> PRT
<213> Lama pocos
<400> 3113
Asn Val Lys Asp Trp Gly Ser Ser Asn Gln Tyr Tyr Asp Tyr
1 5 10
<210> 3114
<211> 23
<212> PRT
<213> Lama pocos
<400> 3114
Ala Ala Val Pro Ser Thr Tyr Tyr Asn Gly Ser Tyr Tyr Tyr Thr Cys
1 5 10 15
His Pro Gly Gly Met Asp Tyr
20
<210> 3115
<211> 23
<212> PRT
<213> Lama pocos
<400> 3115
Ala Ala Val Pro Ser Thr Tyr Tyr Ser Gly Thr Tyr Tyr Tyr Asn Cys
1 5 10 15
His Pro Gly Gly Met Asp Tyr
20
<210> 3116
<211> 23
<212> PRT
<213> Lama pocos
<400> 3116
Ala Thr Ala Pro Gly Thr Tyr Tyr Lys Gly Ser Tyr Tyr Pro Met Cys
1 5 10 15
His Tyr Tyr Gly Met Asp Tyr
20
<210> 3117
<211> 23
<212> PRT
<213> Lama pocos
<400> 3117
Ala Thr Arg Pro Leu Thr Tyr Tyr Ser Gly Ser Tyr Tyr Thr Thr Cys
1 5 10 15
Ser Asp Tyr Gly Met Asp Tyr
20
<210> 3118
<211> 23
<212> PRT
<213> Lama pocos
<400> 3118
Ala Ala Val Pro Ser Thr Tyr Tyr Ser Gly Ser Tyr Tyr Tyr Thr Cys
1 5 10 15
His Pro Gly Gly Met Asp Tyr
20
<210> 3119
<211> 23
<212> PRT
<213> Lama pocos
<400> 3119
Ala Ala Val Pro Ser Thr Tyr Tyr Ser Gly Ser Tyr Tyr Tyr Thr Cys
1 5 10 15
His Pro Gly Gly Met Asp Tyr
20
<210> 3120
<211> 23
<212> PRT
<213> Lama pocos
<400> 3120
Ala Ala Val Pro Ser Thr Tyr Tyr Ser Gly Ser Tyr Tyr Tyr Thr Cys
1 5 10 15
His Pro Gly Gly Met Asp Tyr
20
<210> 3121
<211> 23
<212> PRT
<213> Lama pocos
<400> 3121
Ala Ala Val Pro Ser Thr Tyr Tyr Ser Gly Ser Tyr Tyr Tyr Thr Cys
1 5 10 15
His Pro Gly Gly Met Asp Tyr
20
<210> 3122
<211> 23
<212> PRT
<213> Lama pocos
<400> 3122
Ala Ser Phe Pro Ser Thr Tyr Tyr Ser Gly Ser Tyr Tyr Tyr Thr Cys
1 5 10 15
His Pro Gly Gly Met Asp Tyr
20
<210> 3123
<211> 23
<212> PRT
<213> Lama pocos
<400> 3123
Ala Ala Val Pro Ser Thr Tyr Tyr Ser Gly Thr Tyr Tyr Tyr Asn Cys
1 5 10 15
His Pro Gly Ala Met His Tyr
20
<210> 3124
<211> 23
<212> PRT
<213> Lama pocos
<400> 3124
Ala Ala Val Pro Ser Thr Tyr Tyr Ser Gly Thr Tyr Tyr Tyr Asn Cys
1 5 10 15
His Pro Gly Ala Met His Tyr
20
<210> 3125
<211> 23
<212> PRT
<213> Lama pocos
<400> 3125
Ala Ala Val Pro Ser Thr Tyr Tyr Ser Gly Thr Tyr Tyr Tyr Thr Cys
1 5 10 15
His Pro Gly Gly Met Asp Tyr
20
<210> 3126
<211> 23
<212> PRT
<213> Lama pocos
<400> 3126
Ala Ala Val Pro Ser Thr Tyr Tyr Ser Gly Thr Tyr Tyr Tyr Thr Cys
1 5 10 15
His Pro Gly Gly Met Asp Tyr
20
<210> 3127
<211> 20
<212> PRT
<213> Homo sapiens
<400> 3127
Ala Arg Ala Val Val Gly Ile Val Val Val Pro Ala Ala Gly Arg Arg
1 5 10 15
Ala Phe Asp Ile
20
<210> 3128
<211> 18
<212> PRT
<213> Homo sapiens
<400> 3128
Ala Lys Asp Arg Phe Gln Phe Ala Arg Ser Trp Tyr Gly Asp Tyr Phe
1 5 10 15
Asp Tyr
<210> 3129
<211> 17
<212> PRT
<213> Homo sapiens
<400> 3129
Ala Arg Ile Asn Thr Ala Ala Tyr Asp Tyr Asp Ser Thr Thr Phe Asp
1 5 10 15
Ile
<210> 3130
<211> 17
<212> PRT
<213> Homo sapiens
<400> 3130
Ala Arg Glu Arg Asp Asp Ile Phe Pro Met Gly Leu Asn Ala Phe Asp
1 5 10 15
Ile
<210> 3131
<211> 14
<212> PRT
<213> Homo sapiens
<400> 3131
Ala Arg Gly Asp Ser Ser Gly Tyr Tyr Tyr Tyr Phe Asp Tyr
1 5 10
<210> 3132
<211> 16
<212> PRT
<213> Homo sapiens
<400> 3132
Ala Ser Asp Tyr Phe Asp Ser Ser Gly Tyr Tyr His Ser Phe Asp Tyr
1 5 10 15
<210> 3133
<211> 20
<212> PRT
<213> Homo sapiens
<400> 3133
Ala Arg Asp Tyr Thr Arg Gly Ala Trp Phe Gly Glu Ser Leu Ile Gly
1 5 10 15
Gly Phe Asp Asn
20
<210> 3134
<211> 19
<212> PRT
<213> Homo sapiens
<400> 3134
Ala Thr Arg Thr Tyr Asp Ser Ser Gly Tyr Arg Pro Tyr Tyr Tyr Gly
1 5 10 15
Leu Asp Val
<210> 3135
<211> 17
<212> PRT
<213> Homo sapiens
<400> 3135
Ala Arg Asp Leu Trp Trp Asn Asp Gln Ala His Tyr Tyr Gly Met Asp
1 5 10 15
Val
<210> 3136
<211> 8
<212> PRT
<213> Lama pocos
<400> 3136
Arg Val Phe Val Gly Trp His Tyr
1 5
<210> 3137
<211> 8
<212> PRT
<213> Lama pocos
<400> 3137
Thr Val Tyr Val Gly Tyr Glu Tyr
1 5
<210> 3138
<211> 8
<212> PRT
<213> Lama pocos
<400> 3138
Glu Val Glu Val Gly Lys Trp Tyr
1 5
<210> 3139
<211> 8
<212> PRT
<213> Lama pocos
<400> 3139
Tyr Val Trp Val Gly Gln Glu Tyr
1 5
<210> 3140
<211> 8
<212> PRT
<213> Lama pocos
<400> 3140
Trp Val Ile Val Gly Glu Tyr Tyr
1 5
<210> 3141
<211> 8
<212> PRT
<213> Lama pocos
<400> 3141
Tyr Val Tyr Val Gly Ser Ser Tyr
1 5
<210> 3142
<211> 8
<212> PRT
<213> Lama pocos
<400> 3142
Phe Val Tyr Val Gly Arg Ser Tyr
1 5
<210> 3143
<211> 8
<212> PRT
<213> Lama pocos
<400> 3143
Ile Val Trp Val Gly Ala Gln Tyr
1 5
<210> 3144
<211> 8
<212> PRT
<213> Lama pocos
<400> 3144
His Val Trp Val Gly Ser Leu Tyr
1 5
<210> 3145
<211> 8
<212> PRT
<213> Lama pocos
<400> 3145
Tyr Val Tyr Val Gly Ala Ser Tyr
1 5
<210> 3146
<211> 8
<212> PRT
<213> Lama pocos
<400> 3146
Tyr Val Tyr Val Gly Ser Ser Tyr
1 5
<210> 3147
<211> 9
<212> PRT
<213> Lama pocos
<400> 3147
Arg Ala Val Tyr Val Gly Met His Tyr
1 5
<210> 3148
<211> 8
<212> PRT
<213> Lama pocos
<400> 3148
Tyr Val Tyr Val Gly Lys Ser Tyr
1 5
<210> 3149
<211> 8
<212> PRT
<213> Lama pocos
<400> 3149
Phe Val Gly Val Gly Thr His Tyr
1 5
<210> 3150
<211> 8
<212> PRT
<213> Lama pocos
<400> 3150
Phe Val Tyr Val Gly Lys Ser Tyr
1 5
<210> 3151
<211> 8
<212> PRT
<213> Lama pocos
<400> 3151
Phe Val Tyr Val Gly Lys Ser Tyr
1 5
<210> 3152
<211> 14
<212> PRT
<213> Lama pocos
<400> 3152
Asn Val Lys Asp Phe Gly Thr His His Tyr Ala Tyr Asp Tyr
1 5 10
<210> 3153
<211> 14
<212> PRT
<213> Lama pocos
<400> 3153
Asn Val Lys Asp Lys Gly Met Ala Val Gln Trp Tyr Asp Tyr
1 5 10
<210> 3154
<211> 14
<212> PRT
<213> Lama pocos
<400> 3154
Asn Val Lys Asp Glu Gly Asp Met Phe Thr Ala Tyr Asp Tyr
1 5 10
<210> 3155
<211> 14
<212> PRT
<213> Lama pocos
<400> 3155
Asn Val Lys Asp Ser Gly Gln Trp Arg Gln Glu Tyr Asp Tyr
1 5 10
<210> 3156
<211> 14
<212> PRT
<213> Lama pocos
<400> 3156
Asn Val Lys Asp Phe Gly Tyr Thr Trp His Glu Tyr Asp Tyr
1 5 10
<210> 3157
<211> 8
<212> PRT
<213> Lama pocos
<400> 3157
Val Val Trp Val Gly His Asn Tyr
1 5
<210> 3158
<211> 14
<212> PRT
<213> Lama pocos
<400> 3158
Asn Val Lys Asp Tyr Gly Gln Ala His Ala Tyr Tyr Asp Tyr
1 5 10
<210> 3159
<211> 13
<212> PRT
<213> Lama pocos
<400> 3159
Asn Val Lys Asp Thr Gly Thr Thr Glu Asp Tyr Asp Tyr
1 5 10
<210> 3160
<211> 14
<212> PRT
<213> Lama pocos
<400> 3160
Asn Val Lys Asp Ala Gly Arg Val Tyr Asn Ser Tyr Asp Tyr
1 5 10
<210> 3161
<211> 14
<212> PRT
<213> Lama pocos
<400> 3161
Asn Val Lys Asp Thr Gly Thr Tyr Arg Phe Tyr Tyr Asp Tyr
1 5 10
<210> 3162
<211> 14
<212> PRT
<213> Lama pocos
<400> 3162
Asn Val Lys Asp Ala Gly Val Tyr Asn Arg Tyr Tyr Asp Tyr
1 5 10
<210> 3163
<211> 14
<212> PRT
<213> Lama pocos
<400> 3163
Asn Val Lys Asp Trp Gly Phe Ala Ser His Ala Tyr Asp Tyr
1 5 10
<210> 3164
<211> 14
<212> PRT
<213> Lama pocos
<400> 3164
Asn Val Lys Asp Phe Gly Trp Gln His Gln Glu Tyr Asp Tyr
1 5 10
<210> 3165
<211> 14
<212> PRT
<213> Lama pocos
<400> 3165
Asn Val Lys Asp Ser Gly Ser Phe Asn Gln Ala Tyr Asp Tyr
1 5 10
<210> 3166
<211> 14
<212> PRT
<213> Lama pocos
<400> 3166
Asn Val Lys Asp Tyr Gly Val His Phe Lys Arg Tyr Asp Tyr
1 5 10
<210> 3167
<211> 14
<212> PRT
<213> Lama pocos
<400> 3167
Asn Val Lys Asp Ala Gly Asn Thr Thr Ser Ala Tyr Asp Tyr
1 5 10
<210> 3168
<211> 8
<212> PRT
<213> Lama pocos
<400> 3168
Glu Val Gln Val Gly Ala Trp Tyr
1 5
<210> 3169
<211> 14
<212> PRT
<213> Lama pocos
<400> 3169
Asn Val Lys Asp Ile Asp Ala Glu Ala Tyr Ala Tyr Asp Tyr
1 5 10
<210> 3170
<211> 14
<212> PRT
<213> Lama pocos
<400> 3170
Asn Val Lys Asp Ser Gly Gln Trp Arg Val Gln Tyr Asp Tyr
1 5 10
<210> 3171
<211> 14
<212> PRT
<213> Lama pocos
<400> 3171
Asn Val Lys Asp His Gly Ala Gln Asn Gln Met Tyr Asp Tyr
1 5 10
<210> 3172
<211> 14
<212> PRT
<213> Lama pocos
<400> 3172
Asn Val Lys Asp Val Gly His His Tyr Glu Tyr Tyr Asp Tyr
1 5 10
<210> 3173
<211> 14
<212> PRT
<213> Lama pocos
<400> 3173
Asn Val Lys Asp Lys Gly Gln Met Arg Ala Ala Tyr Asp Tyr
1 5 10
<210> 3174
<211> 14
<212> PRT
<213> Lama pocos
<400> 3174
Asn Val Lys Asp Tyr Gly Ser Ser Tyr Tyr Lys Tyr Asp Tyr
1 5 10
<210> 3175
<211> 13
<212> PRT
<213> Lama pocos
<400> 3175
Asn Val Lys Asp Ala Gly Ser Ser Tyr Trp Asp Tyr Asp
1 5 10
<210> 3176
<211> 18
<212> PRT
<213> Lama pocos
<400> 3176
Ala Ala Ala Arg Trp Gly Arg Thr Lys Pro Leu Asn Thr Tyr Tyr Tyr
1 5 10 15
Ser Tyr
<210> 3177
<211> 8
<212> PRT
<213> Lama pocos
<400> 3177
Arg Val His Val Gly Ala His Tyr
1 5
<210> 3178
<211> 17
<212> PRT
<213> Lama pocos
<400> 3178
Ala Ala Ala Thr Glu Gly His Ala His Ala Leu Tyr Arg Leu His Tyr
1 5 10 15
Tyr
<210> 3179
<211> 8
<212> PRT
<213> Lama pocos
<400> 3179
Arg Val Trp Val Gly Thr His Tyr
1 5
<210> 3180
<211> 18
<212> PRT
<213> Lama pocos
<400> 3180
Ala Ala Ala Tyr Val Gly Ala Glu Asn Pro Leu Pro Tyr Ser Met Tyr
1 5 10 15
Gly Tyr
<210> 3181
<211> 18
<212> PRT
<213> Lama pocos
<400> 3181
Ala Ala Ala Asp Tyr Gly Ala Ser Asp Pro Leu Trp Phe Ile His Tyr
1 5 10 15
Leu Tyr
<210> 3182
<211> 18
<212> PRT
<213> Lama pocos
<400> 3182
Ala Ala Ala Asn Tyr Gly Ser Asn Phe Pro Leu Ala Glu Glu Asp Tyr
1 5 10 15
Trp Tyr
<210> 3183
<211> 19
<212> PRT
<213> Lama pocos
<400> 3183
Ala Ala Ala Tyr Tyr Phe Gly Asp Asp Ile Pro Leu Trp Trp Glu Ala
1 5 10 15
Tyr Ser Tyr
<210> 3184
<211> 18
<212> PRT
<213> Lama pocos
<400> 3184
Ala Ala Ala Arg Trp Gly Arg His Met Pro Leu Ser Ala Thr Glu Tyr
1 5 10 15
Ser Tyr
<210> 3185
<211> 18
<212> PRT
<213> Lama pocos
<400> 3185
Ala Ala Ala Ala Trp Gly Asn Ser Ala Pro Leu Thr Thr Tyr Arg Tyr
1 5 10 15
Tyr Tyr
<210> 3186
<211> 8
<212> PRT
<213> Lama pocos
<400> 3186
Tyr Val Tyr Val Gly Ala Gln Tyr
1 5
<210> 3187
<211> 18
<212> PRT
<213> Lama pocos
<400> 3187
Ala Ala Ala Asp Trp Gly Tyr Asp Trp Pro Leu Trp Asp Glu Trp Tyr
1 5 10 15
Trp Tyr
<210> 3188
<211> 18
<212> PRT
<213> Lama pocos
<400> 3188
Ala Ala Ala Asn Tyr Gly Ala Asn Tyr Pro Leu Tyr Ser Gln Gln Tyr
1 5 10 15
Ser Tyr
<210> 3189
<211> 18
<212> PRT
<213> Lama pocos
<400> 3189
Ala Ala Ala Asn Tyr Gly Ala Asn Glu Pro Leu Gln Tyr Thr His Tyr
1 5 10 15
Asn Tyr
<210> 3190
<211> 18
<212> PRT
<213> Lama pocos
<400> 3190
Ala Ala Ala Ser Tyr Gly Ala Ala His Pro Leu Ser Ile Met Arg Tyr
1 5 10 15
Tyr Tyr
<210> 3191
<211> 18
<212> PRT
<213> Lama pocos
<400> 3191
Ala Ala Ala Ser Tyr Gly Ala Asn Phe Pro Leu Lys Ala Ser Asp Tyr
1 5 10 15
Ser Tyr
<210> 3192
<211> 18
<212> PRT
<213> Lama pocos
<400> 3192
Ala Ala Ala Asp Trp Gly Tyr Asp Trp Pro Leu Trp Asp Glu Trp Tyr
1 5 10 15
Trp Tyr
<210> 3193
<211> 18
<212> PRT
<213> Lama pocos
<400> 3193
Ala Ala Ala Thr Trp Gly His Ser Trp Pro Leu Tyr Asn Asp Glu Tyr
1 5 10 15
Trp Tyr
<210> 3194
<211> 18
<212> PRT
<213> Lama pocos
<400> 3194
Ala Ala Ala Ala Trp Gly Tyr Ala Trp Pro Leu His Gln Asp Asp Tyr
1 5 10 15
Trp Tyr
<210> 3195
<211> 18
<212> PRT
<213> Lama pocos
<400> 3195
Ala Ala Ala Thr Trp Gly Tyr Ser Trp Pro Leu Ile Ala Glu Tyr Asn
1 5 10 15
Trp Tyr
<210> 3196
<211> 8
<212> PRT
<213> Lama pocos
<400> 3196
Phe Val Lys Val Gly Asn Trp Tyr
1 5
<210> 3197
<211> 18
<212> PRT
<213> Lama pocos
<400> 3197
Ala Ala Ala Asn Trp Gly Tyr Ser Trp Pro Leu Tyr Glu Ala Asp Asp
1 5 10 15
Trp Tyr
<210> 3198
<211> 8
<212> PRT
<213> Lama pocos
<400> 3198
Tyr Val Tyr Val Gly Gly Ser Tyr
1 5
<210> 3199
<211> 8
<212> PRT
<213> Lama pocos
<400> 3199
Arg Val Phe Val Gly Met His Tyr
1 5
<210> 3200
<211> 18
<212> PRT
<213> Lama pocos
<400> 3200
Ala Ala Ala Asn Trp Gly Tyr Ser Trp Pro Leu Tyr Gln Thr Glu Tyr
1 5 10 15
Trp Tyr
<210> 3201
<211> 8
<212> PRT
<213> Lama pocos
<400> 3201
Tyr Val Lys Val Gly Glu Trp Tyr
1 5
<210> 3202
<211> 8
<212> PRT
<213> Lama pocos
<400> 3202
Tyr Val Val Val Gly Trp Gly Tyr
1 5
<210> 3203
<211> 8
<212> PRT
<213> Lama pocos
<400> 3203
Phe Val Val Val Gly Asn Gly Tyr
1 5
<210> 3204
<211> 8
<212> PRT
<213> Lama pocos
<400> 3204
Tyr Val Tyr Val Gly Gly Ser Tyr
1 5
<210> 3205
<211> 8
<212> PRT
<213> Lama pocos
<400> 3205
Leu Val Tyr Val Gly Ala Thr Tyr
1 5
<210> 3206
<211> 8
<212> PRT
<213> Lama pocos
<400> 3206
Tyr Val Tyr Val Gly Ala Ser Tyr
1 5
<210> 3207
<211> 8
<212> PRT
<213> Lama pocos
<400> 3207
Tyr Val Tyr Val Gly Gly Ser Tyr
1 5
<210> 3208
<211> 8
<212> PRT
<213> Lama pocos
<400> 3208
Tyr Val Tyr Val Gly Ala Ser Tyr
1 5
<210> 3209
<211> 8
<212> PRT
<213> Lama pocos
<400> 3209
Ala Val Gln Val Gly Tyr Trp Tyr
1 5
<210> 3210
<211> 8
<212> PRT
<213> Lama pocos
<400> 3210
Tyr Val Tyr Val Gly Ala Gly Tyr
1 5
<210> 3211
<211> 8
<212> PRT
<213> Lama pocos
<400> 3211
Tyr Val Trp Val Gly Arg Ser Tyr
1 5
<210> 3212
<211> 8
<212> PRT
<213> Lama pocos
<400> 3212
Tyr Val Tyr Val Gly Ser Ser Tyr
1 5
<210> 3213
<211> 8
<212> PRT
<213> Lama pocos
<400> 3213
Tyr Val Tyr Val Gly Glu Ser Tyr
1 5
<210> 3214
<211> 8
<212> PRT
<213> Lama pocos
<400> 3214
Val Val Trp Val Gly Glu Val Tyr
1 5
<210> 3215
<211> 14
<212> PRT
<213> Lama pocos
<400> 3215
Asn Val Lys Asp Glu Gly Asn Thr Thr Ala Tyr Tyr Asp Tyr
1 5 10
<210> 3216
<211> 14
<212> PRT
<213> Lama pocos
<400> 3216
Asn Val Lys Asp Phe Gly Thr Gln Glu His Tyr Tyr Asp Tyr
1 5 10
<210> 3217
<211> 14
<212> PRT
<213> Lama pocos
<400> 3217
Asn Val Lys Asp Phe Gly Gly Tyr Arg Tyr Tyr Tyr Asp Tyr
1 5 10
<210> 3218
<211> 14
<212> PRT
<213> Lama pocos
<400> 3218
Asn Val Lys Asp Glu Gly Ala Ile Ala Lys Asn Tyr Asp Tyr
1 5 10
<210> 3219
<211> 14
<212> PRT
<213> Lama pocos
<400> 3219
Asn Val Lys Asp Glu Gly Tyr Thr Gly Tyr Tyr Tyr Asp Tyr
1 5 10
<210> 3220
<211> 14
<212> PRT
<213> Lama pocos
<400> 3220
Asn Val Lys Asp Trp Gly Ser Gln Asp Arg Tyr Tyr Asp Tyr
1 5 10
<210> 3221
<211> 14
<212> PRT
<213> Lama pocos
<400> 3221
Asn Val Lys Asp Glu Gly Lys Ser Ser Gln Val Tyr Asp Tyr
1 5 10
<210> 3222
<211> 14
<212> PRT
<213> Lama pocos
<400> 3222
Asn Val Lys Asp Val Gly Asn Asp Gln Lys Ser Tyr Asp Tyr
1 5 10
<210> 3223
<211> 14
<212> PRT
<213> Lama pocos
<400> 3223
Asn Val Lys Asp Trp Gly Thr Tyr Ser Thr Tyr Tyr Asp Tyr
1 5 10
<210> 3224
<211> 8
<212> PRT
<213> Lama pocos
<400> 3224
Tyr Val Tyr Val Gly Ala Ser Tyr
1 5
<210> 3225
<211> 14
<212> PRT
<213> Lama pocos
<400> 3225
Asn Val Lys Asp Trp Gly Trp Leu Ala Gln Tyr Tyr Asp Tyr
1 5 10
<210> 3226
<211> 14
<212> PRT
<213> Lama pocos
<400> 3226
Asn Val Lys Asp Glu Gly Met Trp Gln His Tyr Tyr Asp Tyr
1 5 10
<210> 3227
<211> 14
<212> PRT
<213> Lama pocos
<400> 3227
Asn Val Lys Asp Glu Gly Asn Ser Gln Ser His Tyr Asp Tyr
1 5 10
<210> 3228
<211> 14
<212> PRT
<213> Lama pocos
<400> 3228
Asn Val Lys Asp Ala Gly Asn Ser Lys Ala Leu Tyr Asp Tyr
1 5 10
<210> 3229
<211> 14
<212> PRT
<213> Lama pocos
<400> 3229
Asn Val Lys Asp Trp Gly Arg Ala Gly Ala Arg Tyr Asp Tyr
1 5 10
<210> 3230
<211> 14
<212> PRT
<213> Lama pocos
<400> 3230
Asn Val Lys Asp Met Asp Arg Trp Arg Thr Thr Tyr Asp Tyr
1 5 10
<210> 3231
<211> 8
<212> PRT
<213> Lama pocos
<400> 3231
Tyr Val Trp Val Gly Asn Gln Tyr
1 5
<210> 3232
<211> 14
<212> PRT
<213> Lama pocos
<400> 3232
Asn Val Lys Asp Trp Gly Tyr Glu Tyr Glu Gly Tyr Asp Tyr
1 5 10
<210> 3233
<211> 14
<212> PRT
<213> Lama pocos
<400> 3233
Asn Val Lys Asp Thr Gly Thr Tyr Gln Ala Trp Tyr Asp Tyr
1 5 10
<210> 3234
<211> 14
<212> PRT
<213> Lama pocos
<400> 3234
Asn Val Lys Asp Trp Gly Gly Tyr Gln Trp Tyr Tyr Asp Tyr
1 5 10
<210> 3235
<211> 14
<212> PRT
<213> Lama pocos
<400> 3235
Asn Val Lys Asp Tyr Gly Ala Gln Ala His Tyr Tyr Asp Tyr
1 5 10
<210> 3236
<211> 14
<212> PRT
<213> Lama pocos
<400> 3236
Asn Val Lys Asp Trp Gly Thr Tyr Asn Ser Tyr Tyr Asp Tyr
1 5 10
<210> 3237
<211> 8
<212> PRT
<213> Lama pocos
<400> 3237
Leu Val Tyr Val Gly Ser Thr Tyr
1 5
<210> 3238
<211> 18
<212> PRT
<213> Lama pocos
<400> 3238
Ala Ala Ala His Tyr Gly Asp Asn Phe Pro Leu Ala Tyr Gln Ala Tyr
1 5 10 15
Leu Tyr
<210> 3239
<211> 18
<212> PRT
<213> Lama pocos
<400> 3239
Ala Ala Ala Arg Trp Gly Arg Asp Glu Pro Leu Tyr His Tyr Tyr Tyr
1 5 10 15
Ser Tyr
<210> 3240
<211> 14
<212> PRT
<213> Lama pocos
<400> 3240
Asn Val Lys Asp Ile Gly Ala Gln Glu Val His Tyr Asp Tyr
1 5 10
<210> 3241
<211> 18
<212> PRT
<213> Lama pocos
<400> 3241
Ala Ala Ala Asn Tyr Gly Asn Asn Trp Pro Leu Thr Gly Val Asn Tyr
1 5 10 15
Trp Tyr
<210> 3242
<211> 8
<212> PRT
<213> Lama pocos
<400> 3242
Tyr Val Trp Val Gly Asp Ser Tyr
1 5
<210> 3243
<211> 18
<212> PRT
<213> Lama pocos
<400> 3243
Ala Ala Ala Lys Tyr Gly Gln Asn Phe Pro Leu Ser Tyr His Ala Tyr
1 5 10 15
Arg Tyr
<210> 3244
<211> 18
<212> PRT
<213> Lama pocos
<400> 3244
Ala Ala Ala Arg Tyr Gly Arg Ser Asp Pro Leu His Tyr His Glu Tyr
1 5 10 15
Ser Tyr
<210> 3245
<211> 18
<212> PRT
<213> Lama pocos
<400> 3245
Ala Ala Ala Ser Trp Gly Tyr Thr Trp Pro Leu Tyr Thr Tyr Asp Tyr
1 5 10 15
Trp Tyr
<210> 3246
<211> 14
<212> PRT
<213> Lama pocos
<400> 3246
Asn Val Lys Asp Ser Gly Gln Tyr Arg Glu Asn Tyr Asp Tyr
1 5 10
<210> 3247
<211> 8
<212> PRT
<213> Lama pocos
<400> 3247
Trp Val Tyr Val Gly Asp Tyr Tyr
1 5
<210> 3248
<211> 18
<212> PRT
<213> Lama pocos
<400> 3248
Ala Ala Ala Arg Trp Gly Arg Gln Tyr Pro Leu Thr Phe Val Tyr Tyr
1 5 10 15
Ser Tyr
<210> 3249
<211> 18
<212> PRT
<213> Lama pocos
<400> 3249
Ala Ala Ala Arg Trp Gly Arg Thr Tyr Pro Leu Ser Tyr Met Ala Tyr
1 5 10 15
Thr Tyr
<210> 3250
<211> 18
<212> PRT
<213> Lama pocos
<400> 3250
Ala Ala Ala Arg Trp Gly Arg Tyr Glu Pro Leu His Tyr Ala Tyr Tyr
1 5 10 15
Ser Tyr
<210> 3251
<211> 18
<212> PRT
<213> Lama pocos
<400> 3251
Ala Ala Ala Ser Tyr Gly Ala Asn Trp Pro Leu Val Ser Ala Ala Tyr
1 5 10 15
Thr Tyr
<210> 3252
<211> 19
<212> PRT
<213> Lama pocos
<400> 3252
Ala Ala Ala Arg Tyr Gly His Ala Gln Ala Pro Leu His Tyr Phe Trp
1 5 10 15
Tyr Gly Tyr
<210> 3253
<211> 8
<212> PRT
<213> Lama pocos
<400> 3253
Tyr Val Tyr Val Gly Phe Ser Tyr
1 5
<210> 3254
<211> 8
<212> PRT
<213> Lama pocos
<400> 3254
Tyr Val Tyr Val Gly Ser Ser Tyr
1 5
<210> 3255
<211> 8
<212> PRT
<213> Lama pocos
<400> 3255
Tyr Val Tyr Val Gly Ala Ser Tyr
1 5
<210> 3256
<211> 8
<212> PRT
<213> Lama pocos
<400> 3256
Ala Val Met Val Gly Phe Trp Tyr
1 5
<210> 3257
<211> 8
<212> PRT
<213> Lama pocos
<400> 3257
Tyr Val Tyr Val Gly Ser Ser Tyr
1 5
<210> 3258
<211> 8
<212> PRT
<213> Lama pocos
<400> 3258
Ala Val His Val Gly Gln Thr Tyr
1 5
<210> 3259
<211> 8
<212> PRT
<213> Lama pocos
<400> 3259
Tyr Val Trp Val Gly His Thr Tyr
1 5
<210> 3260
<211> 8
<212> PRT
<213> Lama pocos
<400> 3260
Tyr Val Tyr Val Gly Thr Ser Tyr
1 5
<210> 3261
<211> 8
<212> PRT
<213> Lama pocos
<400> 3261
Tyr Val Tyr Val Gly Tyr Ser Tyr
1 5
<210> 3262
<211> 11
<212> PRT
<213> Lama pocos
<400> 3262
Ala Ile Gly Leu Asn Leu Ser Ser Ser Ser Val
1 5 10
<210> 3263
<211> 18
<212> PRT
<213> Lama pocos
<400> 3263
Ala Ala Ala Gly Leu Gly Thr Val Val Ser Glu Trp Asp Tyr Asp Tyr
1 5 10 15
Asp Tyr
<210> 3264
<211> 13
<212> PRT
<213> Lama pocos
<400> 3264
His Ala Leu Ile Lys Asn Glu Leu Gly Phe Leu Asp Tyr
1 5 10
<210> 3265
<211> 13
<212> PRT
<213> Lama pocos
<400> 3265
His Ala Leu Ile Lys Asn Glu Leu Gly Phe Leu Asp Tyr
1 5 10
<210> 3266
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3266
Met Gln Ala Leu Gln Thr Pro Gln Thr
1 5
<210> 3267
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3267
Gln Gln Tyr Asn Lys Trp Pro Pro Trp Thr
1 5 10
<210> 3268
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3268
Gln Gln Tyr Tyr Ser Ser Pro Tyr Ala
1 5
<210> 3269
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3269
His Gln Tyr Tyr Asn Thr Pro Arg Thr
1 5
<210> 3270
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3270
Arg Gln Arg Ser Asn Trp Pro Pro Thr
1 5
<210> 3271
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3271
Gln Gln Ser Tyr Ser Thr Pro Pro Thr
1 5
<210> 3272
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3272
Gln Gln Thr Tyr Arg Pro Pro Trp Thr
1 5
<210> 3273
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3273
Met Gln Thr Leu Gln Thr Pro Tyr Thr
1 5
<210> 3274
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3274
Gln Gln Tyr Asp Asn Leu Pro Leu Thr
1 5
<210> 3275
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3275
Met Gln Ala Thr Gln Phe Pro Tyr Thr
1 5
<210> 3276
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3276
Gln Gln Tyr Tyr Ser Thr Tyr Gly Ser
1 5
<210> 3277
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3277
Gly Thr Trp Asp Ser Ser Leu Ser Val Val Val
1 5 10
<210> 3278
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3278
Ala Ala Trp Asp Asp Ser Leu Asn Gly Val Val
1 5 10
<210> 3279
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3279
Leu Gln His Asn Asn Tyr Pro Leu Thr
1 5
<210> 3280
<211> 9
<212> PRT
<213> Mus musculus
<400> 3280
Ala Leu Trp Tyr Ser Asn His Trp Val
1 5
<210> 3281
<211> 9
<212> PRT
<213> Mus musculus
<400> 3281
Gln Gln Gly Asn Thr Leu Pro Tyr Thr
1 5
<210> 3282
<211> 8
<212> PRT
<213> Mus musculus
<400> 3282
Leu Gln Tyr Asp Glu Phe Arg Thr
1 5
<210> 3283
<211> 9
<212> PRT
<213> Mus musculus
<400> 3283
Ala Leu Trp Tyr Ser Asn Gln Phe Ile
1 5
<210> 3284
<211> 9
<212> PRT
<213> Mus musculus
<400> 3284
Ala Leu Trp Tyr Ser Asn His Trp Val
1 5
<210> 3285
<211> 9
<212> PRT
<213> Mus musculus
<400> 3285
Gln Gln Asn Asn Glu Asp Pro Leu Thr
1 5
<210> 3286
<211> 9
<212> PRT
<213> Mus musculus
<400> 3286
Phe Gln Gly Ser His Val Pro Pro Thr
1 5
<210> 3287
<211> 9
<212> PRT
<213> Mus musculus
<400> 3287
Gln Gln Asn Asn Glu Asp Pro Leu Thr
1 5
<210> 3288
<211> 8
<212> PRT
<213> Mus musculus
<400> 3288
Leu Gln Tyr Asp Glu Phe Arg Thr
1 5
<210> 3289
<211> 9
<212> PRT
<213> Mus musculus
<400> 3289
Ala Leu Trp Tyr Ser Asn Gln Phe Ile
1 5
<210> 3290
<211> 9
<212> PRT
<213> Mus musculus
<400> 3290
Gln Gln Asn Asn Glu Asp Pro Leu Thr
1 5
<210> 3291
<211> 9
<212> PRT
<213> Mus musculus
<400> 3291
Gln Gln Ser Arg Lys Val Pro Trp Thr
1 5
<210> 3292
<211> 9
<212> PRT
<213> Mus musculus
<400> 3292
Gln Gln Trp Ser Ser Asn Pro Pro Thr
1 5
<210> 3293
<211> 9
<212> PRT
<213> Mus musculus
<400> 3293
Gln Gln Ser Arg Lys Val Pro Trp Thr
1 5
<210> 3294
<211> 9
<212> PRT
<213> Mus musculus
<400> 3294
Ala Leu Trp Tyr Ser Asn His Trp Val
1 5
<210> 3295
<211> 11
<212> PRT
<213> Mus musculus
<400> 3295
Ala Ala Trp Asp Asp Ser Leu Ile Tyr Val Leu
1 5 10
<210> 3296
<211> 9
<212> PRT
<213> Mus musculus
<400> 3296
Ala Leu Trp Tyr Asn Asn His Trp Val
1 5
<210> 3297
<211> 9
<212> PRT
<213> Mus musculus
<400> 3297
Gln Gln Trp Ser Ser Tyr Pro Leu Thr
1 5
<210> 3298
<211> 9
<212> PRT
<213> Mus musculus
<400> 3298
Phe Gln Gly Ser His Val Pro Tyr Thr
1 5
<210> 3299
<211> 9
<212> PRT
<213> Mus musculus
<400> 3299
Gln Gln Ser Arg Lys Val Pro Trp Thr
1 5
<210> 3300
<211> 9
<212> PRT
<213> Mus musculus
<400> 3300
Gln Gln Trp Ser Ser Tyr Pro Leu Thr
1 5
<210> 3301
<211> 9
<212> PRT
<213> Mus musculus
<400> 3301
Gln Gln Ser Arg Lys Val Pro Trp Thr
1 5
<210> 3302
<211> 9
<212> PRT
<213> Mus musculus
<400> 3302
Gln Gln Ser Lys Glu Val Pro Trp Thr
1 5
<210> 3303
<211> 9
<212> PRT
<213> Mus musculus
<400> 3303
Gln Gln Ser Asn Glu Asp Pro Tyr Thr
1 5
<210> 3304
<211> 9
<212> PRT
<213> Mus musculus
<400> 3304
Gln Gln Asn Asn Glu Asp Pro Leu Thr
1 5
<210> 3305
<211> 9
<212> PRT
<213> Mus musculus
<400> 3305
Gln Gln Ser Ser Ser Trp Pro Leu Thr
1 5
<210> 3306
<211> 9
<212> PRT
<213> Mus musculus
<400> 3306
Gln Gln Ser Ser Ser Trp Pro Leu Thr
1 5
<210> 3307
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3307
Gln Ser Tyr Asp Ser Ser Asn His Trp Val
1 5 10
<210> 3308
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3308
Gln Gln Ser Tyr Ser Thr Pro Arg Thr
1 5
<210> 3309
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3309
Gln Gln Tyr Tyr Ser Thr Pro Phe Thr
1 5
<210> 3310
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3310
Gln Gln Tyr Gly Ser Ser Arg Ser Trp Thr
1 5 10
<210> 3311
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3311
Gln Gln Ser Tyr Ser Thr Phe Thr Leu Tyr Thr
1 5 10
<210> 3312
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3312
Gln Gln Ser His Ser Phe Pro Phe Thr
1 5
<210> 3313
<211> 8
<212> PRT
<213> Homo sapiens
<400> 3313
Gln Gln Leu Asn Ser Tyr Val Thr
1 5
<210> 3314
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3314
Ala Ala Arg Asp Asp Ser Leu Ser Gly Trp Val
1 5 10
<210> 3315
<211> 8
<212> PRT
<213> Homo sapiens
<400> 3315
Gln Gln Arg Thr Asn Trp Pro Leu
1 5
<210> 3316
<211> 8
<212> PRT
<213> Homo sapiens
<400> 3316
Gln Gln Asn Tyr Ser Thr Trp Thr
1 5
<210> 3317
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3317
Cys Ser Tyr Ala Val Ser Ser Thr Trp Val
1 5 10
<210> 3318
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3318
Gln Gln Arg Ser Asn Trp Pro Pro Ala Phe Thr
1 5 10
<210> 3319
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3319
Gln Gln Arg Ser Asn Trp Pro Pro Lys Ile Thr
1 5 10
<210> 3320
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3320
Gln Gln Tyr Tyr Asn Asn Gln Trp Thr
1 5
<210> 3321
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3321
Gln Gln Ser Phe Val Ser Pro Arg Thr
1 5
<210> 3322
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3322
Leu Gln His Lys Ser Tyr Pro Leu Thr
1 5
<210> 3323
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3323
Gln Gln Tyr Gly Ser Ser Pro Pro Leu Thr
1 5 10
<210> 3324
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3324
Ala Ala Trp Asp Asp Ser Leu Asn Gly Val Val
1 5 10
<210> 3325
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3325
Thr Gln Ala Thr Gln Phe Pro Tyr Thr
1 5
<210> 3326
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3326
Met Gln Gly Thr His Trp Pro Pro Thr
1 5
<210> 3327
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3327
Met Gln Gly Thr His Trp Pro Pro Thr
1 5
<210> 3328
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3328
Ser Ser Tyr Thr Ser Ser Ser Ile Val Val
1 5 10
<210> 3329
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3329
Met Gln Gly Thr His Trp Pro Pro Thr
1 5
<210> 3330
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3330
Leu Gln His Asn Ser Tyr Pro Ile Thr
1 5
<210> 3331
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3331
Gln Ser Tyr Asp Gly Ser Asn His Asn Val Val
1 5 10
<210> 3332
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3332
Gln Ser Tyr Asp Ser Ser Asn His Val Val
1 5 10
<210> 3333
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3333
Gln Gln Tyr Gly Ser Ser Pro Pro Thr
1 5
<210> 3334
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3334
Gln Gln Ser Tyr Ser Ile Pro Arg Thr
1 5
<210> 3335
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3335
Leu Gln His Asn Ser Tyr Pro Leu Thr
1 5
<210> 3336
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3336
Gln Ala Trp Asp Ser Ser Thr Gly Val
1 5
<210> 3337
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3337
His Gln Tyr Ser Lys Trp Pro Val Thr
1 5
<210> 3338
<211> 8
<212> PRT
<213> Homo sapiens
<400> 3338
Met Gln Ala Leu Gln Met Gly Thr
1 5
<210> 3339
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3339
Gln Gln Ser Tyr Ser Thr Pro Pro Tyr Thr
1 5 10
<210> 3340
<211> 8
<212> PRT
<213> Homo sapiens
<400> 3340
Gln Gln Tyr Gly Ser Ser Arg Thr
1 5
<210> 3341
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3341
Gln Gln Tyr Asp Thr Leu Pro Leu Thr
1 5
<210> 3342
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3342
Gln Gln Ser Tyr Ser Thr Pro Arg Thr
1 5
<210> 3343
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3343
Gln Gln Leu Asn Ser Tyr Pro Arg Met Thr
1 5 10
<210> 3344
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3344
Gln Gln Arg Ser Asn Trp Pro Gly Thr
1 5
<210> 3345
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3345
Gln Gln Phe Asn Asn Phe Leu Leu Thr
1 5
<210> 3346
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3346
Gln Gln Tyr Asn Asn Trp Pro Pro Trp Thr
1 5 10
<210> 3347
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3347
Gln Val Trp Asp Ser Ser Ala Asp His Tyr Val
1 5 10
<210> 3348
<211> 12
<212> PRT
<213> Homo sapiens
<400> 3348
Gln Ser Tyr Asp Arg Ser Leu Ser Val Leu Tyr Val
1 5 10
<210> 3349
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3349
Gln Gln Ala Asn Ser Phe Arg Leu Thr
1 5
<210> 3350
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3350
Gln Gln Tyr Gly Arg Ser Pro Tyr Thr
1 5
<210> 3351
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3351
Asn Ser Arg Asp Ser Ser Gly Asn Thr Val Val
1 5 10
<210> 3352
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3352
Gln Gln Tyr His Asn Leu Pro Ile Thr
1 5
<210> 3353
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3353
His Gln Ser Ser Ser Leu Pro Tyr Thr
1 5
<210> 3354
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3354
Thr Thr Trp Asp Ala Ser Arg Gly Gly Trp Val
1 5 10
<210> 3355
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3355
Gln Gln Tyr His Asn Val Pro Pro Ala
1 5
<210> 3356
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3356
Gln Gln Ser Tyr Ser Ser Pro Pro Trp Thr
1 5 10
<210> 3357
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3357
Ala Ala Trp Asp Asp Ser Leu Ser Gly Pro Val
1 5 10
<210> 3358
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3358
Gln His Leu Asn Ile Asp Pro Ile Thr
1 5
<210> 3359
<211> 8
<212> PRT
<213> Homo sapiens
<400> 3359
Gln Gln Arg Gly Asn Ser Ile Thr
1 5
<210> 3360
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3360
Gln Gln Ser Tyr Asn Thr Leu Ala Leu Ser
1 5 10
<210> 3361
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3361
Gln Gln Tyr Ala Asp Leu Pro Tyr Thr
1 5
<210> 3362
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3362
Gln Gln Ser Tyr Ser Pro Pro His Ser
1 5
<210> 3363
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3363
Gln Gln Ser Tyr Ser Thr Pro Cys Thr
1 5
<210> 3364
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3364
Gln Gln Tyr Tyr Ile Thr Pro Gln Leu Thr
1 5 10
<210> 3365
<211> 8
<212> PRT
<213> Homo sapiens
<400> 3365
Gln Gln Tyr Tyr Gly Tyr Pro Thr
1 5
<210> 3366
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3366
Gln Gln Ser Tyr Ser Ala Pro Pro Trp Thr
1 5 10
<210> 3367
<211> 8
<212> PRT
<213> Homo sapiens
<400> 3367
Gln Gln Tyr Gly Ser Ser Arg Thr
1 5
<210> 3368
<211> 12
<212> PRT
<213> Homo sapiens
<400> 3368
Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Trp Val
1 5 10
<210> 3369
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3369
Val Leu Tyr Met Gly Ser Gly Ile Val Val
1 5 10
<210> 3370
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3370
Met Gln Gly Thr His Trp Pro Pro Gly Thr
1 5 10
<210> 3371
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3371
Gln Gln Tyr Asp Asn Leu Pro Arg Thr
1 5
<210> 3372
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3372
Gln Val Trp Asp Ser Ser Ser Asp Pro Tyr Val
1 5 10
<210> 3373
<211> 8
<212> PRT
<213> Homo sapiens
<400> 3373
Gln Gln Tyr Asn Asn Leu Tyr Thr
1 5
<210> 3374
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3374
Gln His Tyr Asn Asn Trp Pro Leu Tyr Thr
1 5 10
<210> 3375
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3375
Met Gln Gly Thr His Trp Pro Pro Gly Thr
1 5 10
<210> 3376
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3376
Gln Gln Tyr Asp Asn Leu Pro Leu Thr
1 5
<210> 3377
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3377
Gln Gln Tyr Asn Ser Tyr Ser His Thr
1 5
<210> 3378
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3378
Gln Gln Ser Tyr Ser Thr Pro Pro Tyr Thr
1 5 10
<210> 3379
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3379
Gln Gln Thr Tyr Ser Thr Pro Arg Thr
1 5
<210> 3380
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3380
Gln Gln Leu Asn Ser Tyr Pro Pro Ile Thr
1 5 10
<210> 3381
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3381
Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val
1 5 10
<210> 3382
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3382
Ala Thr Trp Asp Asp Ser Leu Asn Gly Arg Val
1 5 10
<210> 3383
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3383
Gln Gln Tyr Gly Ser Ser Pro Arg Thr
1 5
<210> 3384
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3384
Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val
1 5 10
<210> 3385
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3385
Gln Gln Tyr Asn Ser Tyr Ser Pro Leu Thr
1 5 10
<210> 3386
<211> 8
<212> PRT
<213> Homo sapiens
<400> 3386
Gln Gln Tyr Tyr Ser Phe Trp Ala
1 5
<210> 3387
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3387
Gln Leu Leu Asn Thr Asp Pro Ile Thr
1 5
<210> 3388
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3388
Gln Gln Ser Tyr Ser Thr Pro Leu Thr
1 5
<210> 3389
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3389
Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val
1 5 10
<210> 3390
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3390
Ala Val Trp Asp Asp Ser Leu Asn Gly Trp Val
1 5 10
<210> 3391
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3391
Gln Gln Ser Tyr Ser Ile Pro Arg Thr
1 5
<210> 3392
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3392
Gln Gln Tyr Gly Ser Ser Pro Trp Thr
1 5
<210> 3393
<211> 5
<212> PRT
<213> Homo sapiens
<400> 3393
Gln Gln Leu Gly Thr
1 5
<210> 3394
<211> 8
<212> PRT
<213> Homo sapiens
<400> 3394
Gln Gln Thr Asn Ser Phe Pro Thr
1 5
<210> 3395
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3395
Gln Gln Tyr Asp Asn Ser Pro Trp Thr
1 5
<210> 3396
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3396
Gln Gln Ser Asp Asn Val Pro Val Thr
1 5
<210> 3397
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3397
Gln Ser Tyr Asp Ser Ala Leu Val Val
1 5
<210> 3398
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3398
Gln Ser Tyr Asp Ser Ser Leu Ser Val Val Val
1 5 10
<210> 3399
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3399
Ser Ser Phe Thr Ser Ser Ser Thr Pro Tyr Val
1 5 10
<210> 3400
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3400
Ala Ala Trp Asp Asp Ser Leu Asn Gly Pro Val
1 5 10
<210> 3401
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3401
Gln Gln Ser Tyr Asn Thr Pro Pro Trp Thr
1 5 10
<210> 3402
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3402
Ala Ala Trp Asp Asp Ser Leu Ser Arg Val Val
1 5 10
<210> 3403
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3403
Ala Ala Trp Asp Asp Ser Leu Ser Gly Val Ile
1 5 10
<210> 3404
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3404
Met Gln Ala Leu Gln Thr Pro Arg Thr
1 5
<210> 3405
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3405
Cys Met Gln Gly Thr His Trp Pro Pro Thr
1 5 10
<210> 3406
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3406
Met Gln Gly Thr His Trp Pro Met Tyr Thr
1 5 10
<210> 3407
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3407
Gln Gln His Asp Asn Val Pro Leu Thr
1 5
<210> 3408
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3408
Gln Gln Leu Asn Ser Tyr Pro Pro Tyr Thr
1 5 10
<210> 3409
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3409
Gln Gln Leu Asn Ser Tyr Pro Phe Thr
1 5
<210> 3410
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3410
Gln Gln Leu Asn Ser Tyr Pro Leu Thr
1 5
<210> 3411
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3411
Gln Gln Ser Tyr Ser Thr Pro Pro Asp Thr
1 5 10
<210> 3412
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3412
Gln Gln Ser Tyr Thr Thr Pro Leu Phe Thr
1 5 10
<210> 3413
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3413
Gln Gln Ser Tyr Thr Thr Pro Leu Phe Thr
1 5 10
<210> 3414
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3414
His Gln Tyr Asp Asn Leu Pro Pro Thr
1 5
<210> 3415
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3415
Gln Gln Leu Asn Ser Tyr Pro Leu Thr
1 5
<210> 3416
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3416
Gln Gln Leu Asn Ser Asn Pro Pro Ile Thr
1 5 10
<210> 3417
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3417
Gln Gln Ser Tyr Ser Thr Pro Pro Tyr Thr
1 5 10
<210> 3418
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3418
Gln Gln Tyr Asn Ser Tyr Pro Tyr Thr
1 5
<210> 3419
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3419
Gln Gln Ser Tyr Ser Thr Pro Arg Thr
1 5
<210> 3420
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3420
Gln Gln Tyr Gly Ser Ser Pro Arg Thr
1 5
<210> 3421
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3421
Gln Gln Tyr Asp Asn Leu Pro Ile Thr
1 5
<210> 3422
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3422
Gln Gln Tyr Gly Ser Ser Pro Trp Thr
1 5
<210> 3423
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3423
Ala Ala Trp Asp Asp Ser Leu Asn Gly Pro Val
1 5 10
<210> 3424
<211> 8
<212> PRT
<213> Homo sapiens
<400> 3424
Gln Gln Tyr Asn Ser Tyr Trp Thr
1 5
<210> 3425
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3425
Ser Ser Asp Ala Gly Ser Asn Asn Val Val
1 5 10
<210> 3426
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3426
Gln Gln Ser Tyr Ser Thr Pro Pro Trp Thr
1 5 10
<210> 3427
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3427
Gln Gln Arg Ser Asn Trp Pro Leu Thr
1 5
<210> 3428
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3428
Gln Gln Tyr Asp Asn Leu Pro Pro Thr
1 5
<210> 3429
<211> 5
<212> PRT
<213> Homo sapiens
<400> 3429
Gln Gln Arg Ile Thr
1 5
<210> 3430
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3430
Gln Gln Ser Tyr Ser Thr Pro Pro Ala Thr
1 5 10
<210> 3431
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3431
Gln Val Trp Asp Ser Ser Ser Asp His Val Val
1 5 10
<210> 3432
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3432
Met Gln Ala Leu Gln Thr Pro Phe Thr
1 5
<210> 3433
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3433
Gln Gln Tyr Asn Asn Tyr Arg Tyr Thr
1 5
<210> 3434
<211> 8
<212> PRT
<213> Homo sapiens
<400> 3434
Gln Gln Tyr Asn Ser Tyr Ser Thr
1 5
<210> 3435
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3435
Met Gln Ala Leu Gln Thr Pro His Thr
1 5
<210> 3436
<211> 8
<212> PRT
<213> Homo sapiens
<400> 3436
Gln Gln Tyr Asn Ser Tyr Ser Thr
1 5
<210> 3437
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3437
Gln Gln Ser Tyr Ser Thr Pro Pro Leu Thr
1 5 10
<210> 3438
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3438
Gln Gln Tyr Gly Ser Ser Pro Arg Thr
1 5
<210> 3439
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3439
Gln Gln Tyr Gly Ser Ser Pro Arg Thr
1 5
<210> 3440
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3440
Gln Gln Tyr Thr Thr Thr Pro Arg Thr
1 5
<210> 3441
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3441
Gln Gln Tyr Gly Thr Thr Pro Arg Thr
1 5
<210> 3442
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3442
Ser Ser Tyr Glu Gly Ser Asn Asn Phe Val Val
1 5 10
<210> 3443
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3443
Gln Val Trp Asp Ser Ser Arg Asp His Val Val
1 5 10
<210> 3444
<211> 12
<212> PRT
<213> Homo sapiens
<400> 3444
Ala Ala Trp Asp Asp Ser Leu Ser Gly Phe Val Val
1 5 10
<210> 3445
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3445
Asn Ser Tyr Thr Ser Ser Ser Thr Arg Val
1 5 10
<210> 3446
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3446
Ser Ser Tyr Ala Gly Ser Asn Asn Tyr Val Val
1 5 10
<210> 3447
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3447
Gln Gln Tyr Asn Ser Tyr Pro Tyr Thr
1 5
<210> 3448
<211> 12
<212> PRT
<213> Homo sapiens
<400> 3448
Ala Ala Trp Asp Asp Ser Leu Asn Gly Ala Trp Val
1 5 10
<210> 3449
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3449
Ser Ser Tyr Thr Ser Ser Ser Thr Trp Val
1 5 10
<210> 3450
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3450
Gln Gln His Asn Ser Ser Pro Leu Thr
1 5
<210> 3451
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3451
Gln Ser Tyr Asp Ser Ser Leu Tyr Ala Val
1 5 10
<210> 3452
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3452
Met Gln Val Leu Gln Ile Pro Tyr Thr
1 5
<210> 3453
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3453
Gln Ser Tyr Asp Ser Gly Asn His Trp Val Val
1 5 10
<210> 3454
<211> 14
<212> PRT
<213> Homo sapiens
<400> 3454
Gly Ala Trp Asp Ser Ser Leu Ser Ala Gly Gly Val Tyr Val
1 5 10
<210> 3455
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3455
Gln Thr Trp Gly Thr Gly Ile Leu Val
1 5
<210> 3456
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3456
Ser Ser Tyr Thr Ser Ser Ser Thr Ser Val Val
1 5 10
<210> 3457
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3457
Gln Gln Tyr Asp Asn Leu Pro Gln Thr
1 5
<210> 3458
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3458
Cys Ser Tyr Ala Gly Ser Ser Thr Leu Val
1 5 10
<210> 3459
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3459
Gln Gln Leu Asn Ser Asp Ser Tyr Thr
1 5
<210> 3460
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3460
Gln Gln Leu Asn Ser Tyr Pro Pro Ala
1 5
<210> 3461
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3461
Gln Gln Arg Asn Asn Trp Pro Pro Glu Trp Thr
1 5 10
<210> 3462
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3462
Gln Gln Tyr Gly Ser Ser Pro Trp Thr
1 5
<210> 3463
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3463
Gln Ser Tyr Asp Ser Ser Asn Leu Val
1 5
<210> 3464
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3464
Ala Ala Trp Asp Asp Ser Leu Asn Gly Val Val
1 5 10
<210> 3465
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3465
Gln Gln Tyr Gly Ser Ser Arg Ala Leu Thr
1 5 10
<210> 3466
<211> 13
<212> PRT
<213> Homo sapiens
<400> 3466
Gln Val Trp Asp Ser Ser Ser Asp His Pro Gly Val Val
1 5 10
<210> 3467
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3467
Gln Gln Tyr Asn Asn Trp Pro Ile Thr
1 5
<210> 3468
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3468
Ser Ser Tyr Thr Ser Ser Ser Thr Leu Leu
1 5 10
<210> 3469
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3469
Gln Gln Ser Tyr Ser Thr Pro Pro Trp Thr
1 5 10
<210> 3470
<211> 13
<212> PRT
<213> Homo sapiens
<400> 3470
Gln Val Trp Asp Ser Ser Ser Asp Arg Pro Gly Val Val
1 5 10
<210> 3471
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3471
Gln Gln Tyr Asn Ser Tyr Pro Trp Thr
1 5
<210> 3472
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3472
Gln Ser Tyr Asp Ser Ser Asn Trp Val
1 5
<210> 3473
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3473
Gln Gln Tyr Asp Asn Leu Pro Leu Thr
1 5
<210> 3474
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3474
Gln Gln Leu Asn Ser Tyr Ser Tyr Thr
1 5
<210> 3475
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3475
Gln Ser Tyr Asp Ser Ser Asn Trp Val
1 5
<210> 3476
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3476
Cys Ser Tyr Ala Gly Ala Ser Thr Phe Val
1 5 10
<210> 3477
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3477
Ser Ser Tyr Thr Ser Ser Ser Thr Arg Val
1 5 10
<210> 3478
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3478
Ser Ser Tyr Thr Ser Ser Thr Thr Arg Val
1 5 10
<210> 3479
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3479
Ser Ser Tyr Arg Gly Ser Ser Thr Pro Tyr Val
1 5 10
<210> 3480
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3480
Leu Leu Ser Tyr Ser Gly Ala Arg Pro Val
1 5 10
<210> 3481
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3481
Gln Gln Tyr Asn Asn Trp Pro Pro Leu Thr
1 5 10
<210> 3482
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3482
Ser Ser Tyr Arg Ser Ser Ser Thr Leu Val
1 5 10
<210> 3483
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3483
Gln Ser Tyr Asp Ser Ser Asn Tyr Trp Val
1 5 10
<210> 3484
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3484
Cys Ser Tyr Ala Gly Ser Ser Thr Trp Val
1 5 10
<210> 3485
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3485
Gln Gln Tyr Asp Asn Leu Pro Ile Thr
1 5
<210> 3486
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3486
Gln Gln Tyr Asn Asn Trp Pro Arg Thr
1 5
<210> 3487
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3487
Gln Val Trp Asp Ser Ser Ser Asp Pro Trp Val
1 5 10
<210> 3488
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3488
Cys Ser Tyr Ala Gly Ala Ser Thr Phe Val
1 5 10
<210> 3489
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3489
Gln Gln Tyr Gly Ser Ser Pro Trp Thr
1 5
<210> 3490
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3490
Gln Gln Ala Asn Ser Phe Pro Leu Thr
1 5
<210> 3491
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3491
Gln Gln Tyr Asp Asn Leu Pro Arg Ser
1 5
<210> 3492
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3492
Gln Gln Ser Tyr Ser Thr Pro Pro Trp Thr
1 5 10
<210> 3493
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3493
Gln Gln Tyr Val Ser Ser Pro Trp Thr
1 5
<210> 3494
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3494
Gln Gln Arg Ser Asn Trp Pro Arg Gly
1 5
<210> 3495
<211> 8
<212> PRT
<213> Homo sapiens
<400> 3495
Gln Gln Tyr Gly Ser Ser Leu Thr
1 5
<210> 3496
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3496
Gln Gln Leu Asn Ser Tyr Pro Gln Gly Thr
1 5 10
<210> 3497
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3497
Gln Gln Tyr Asn Asn Trp Pro Arg Thr
1 5
<210> 3498
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3498
Cys Ser Tyr Ala Gly Ser Ser Thr Arg Leu
1 5 10
<210> 3499
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3499
Gln Gln Ser Tyr Ser Thr Pro Pro Trp Thr
1 5 10
<210> 3500
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3500
Gln Gln Ser Tyr Ser Thr Pro Pro Trp Thr
1 5 10
<210> 3501
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3501
Gln Gln Ser Tyr Ser Thr Pro Pro Ile Thr
1 5 10
<210> 3502
<211> 8
<212> PRT
<213> Homo sapiens
<400> 3502
Gln Gln Arg Arg Asn Trp Gly Thr
1 5
<210> 3503
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3503
Gln Gln Ser Tyr Ser Thr Pro Pro Glu Tyr Thr
1 5 10
<210> 3504
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3504
Gln Gln Leu Asn Ser Tyr Pro Pro Lys Phe Thr
1 5 10
<210> 3505
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3505
Ser Ser Tyr Ala Gly Ser Ser Thr Gln Val
1 5 10
<210> 3506
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3506
Ser Ser Tyr Thr Ser Ser Ser Ala Gln Leu
1 5 10
<210> 3507
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3507
Ser Ser Tyr Thr Ser Gly Ser Thr Gln Val
1 5 10
<210> 3508
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3508
Gln Gln Tyr Asp Asn Leu Pro Ile Thr
1 5
<210> 3509
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3509
Met Gln Gly Thr His Trp Pro Pro Thr
1 5
<210> 3510
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3510
Gln Ser Tyr Asp Ser Ser Leu Ser Gly Val Val
1 5 10
<210> 3511
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3511
Gln Val Trp Asp Ser Ser Ser Asp Pro Trp Val
1 5 10
<210> 3512
<211> 12
<212> PRT
<213> Homo sapiens
<400> 3512
Gln Val Trp Asp Ser Ser Ser Asp His Pro Val Val
1 5 10
<210> 3513
<211> 13
<212> PRT
<213> Homo sapiens
<400> 3513
Gln Ser Tyr Asp Ser Ser Asn His Glu Glu Ile Trp Val
1 5 10
<210> 3514
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3514
Gln Val Trp Asp Asn Asn Ser Asp His Leu Val
1 5 10
<210> 3515
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3515
Gln Gln Tyr Gly Ser Ser Pro Arg Thr
1 5
<210> 3516
<211> 12
<212> PRT
<213> Homo sapiens
<400> 3516
Ala Ala Trp Asp Asp Ser Leu Ser Gly Arg Val Val
1 5 10
<210> 3517
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3517
Ala Ala Trp Asp Asp Ser Leu Asn Gly Pro Val
1 5 10
<210> 3518
<211> 12
<212> PRT
<213> Homo sapiens
<400> 3518
Gln Ser Ala Asp Ser Ser Gly Thr Tyr Leu Val Val
1 5 10
<210> 3519
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3519
Gln Gln Ser Tyr Ser Thr Pro Trp Thr
1 5
<210> 3520
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3520
Ala Ala Trp Asp Asp Ser Leu Asn Gly Pro Val
1 5 10
<210> 3521
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3521
Leu Leu Tyr Tyr Gly Gly Ala Gln Arg Trp Val
1 5 10
<210> 3522
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3522
Tyr Ser Tyr Ala Gly Ser Ser Thr Phe Val
1 5 10
<210> 3523
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3523
Ala Ala Trp Asp Asp Ser Leu Ser Gly Trp Val
1 5 10
<210> 3524
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3524
Gln Gln Tyr Gly Ser Ser Pro Arg Thr
1 5
<210> 3525
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3525
Thr Ser Tyr Ala Gly Ser Asn Asn Phe Val
1 5 10
<210> 3526
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3526
Ser Ser Tyr Thr Ser Ser Ser Thr Gln Val
1 5 10
<210> 3527
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3527
Ser Ser Tyr Thr Ser Ser Ser Thr Gln Val
1 5 10
<210> 3528
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3528
Ser Ser Tyr Thr Val Ser Ser Thr Gln Val
1 5 10
<210> 3529
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3529
Ser Ser Tyr Thr Ser Ser Ser Ala Gln Leu
1 5 10
<210> 3530
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3530
Ser Ser Tyr Thr Ser Ser Ser Ala Gln Val
1 5 10
<210> 3531
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3531
Gln Gln Ser Tyr Ser Thr Pro Pro Thr
1 5
<210> 3532
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3532
Gln Gln Ser Tyr Ser Thr Pro Arg Thr
1 5
<210> 3533
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3533
Leu Gln His Asn Ser Tyr Pro Ile Leu Thr
1 5 10
<210> 3534
<211> 12
<212> PRT
<213> Homo sapiens
<400> 3534
Gln Val Trp Asp Ser Ser Ser Asp His Pro Tyr Val
1 5 10
<210> 3535
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3535
Gln His Tyr Gly Ser Ser Leu Trp Thr
1 5
<210> 3536
<211> 9
<212> PRT
<213> Mus musculus
<400> 3536
Phe Gln Gly Ser His Val Pro Leu Thr
1 5
<210> 3537
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3537
Gln Gln Arg Ser Asn Trp Pro Pro Ala Leu Thr
1 5 10
<210> 3538
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3538
Cys Ser Tyr Ala Gly Ser Ser Thr Trp Val
1 5 10
<210> 3539
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3539
Met Gln Ala Leu Gln Thr Pro Gly Thr
1 5
<210> 3540
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3540
Met Gln Ala Leu Gln Thr Pro Gly Thr
1 5
<210> 3541
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3541
Cys Ser Tyr Ala Gly Val Arg Thr Val Val
1 5 10
<210> 3542
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3542
Cys Ser Tyr Ala Gly Val Arg Thr Val Val
1 5 10
<210> 3543
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3543
Gln Gln Tyr Gly Ser Ser Pro Trp Thr
1 5
<210> 3544
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3544
Gln Gln Tyr Asp Asn Leu Leu Phe Thr
1 5
<210> 3545
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3545
Ser Ser Tyr Thr Ser Ser Ser Thr Leu Trp Val
1 5 10
<210> 3546
<211> 8
<212> PRT
<213> Homo sapiens
<400> 3546
Gln Gln Ser Tyr Ser Thr Phe Thr
1 5
<210> 3547
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3547
Gln Gln Tyr Tyr Thr Ala Pro Leu Thr
1 5
<210> 3548
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3548
Gln Gln Arg Ser Asn Trp Pro Pro Tyr Thr
1 5 10
<210> 3549
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3549
Ser Ser Tyr Thr Ser Ser Thr Thr Trp Val
1 5 10
<210> 3550
<211> 12
<212> PRT
<213> Homo sapiens
<400> 3550
Gln Ser Phe Asp Ser Ser Leu Ser Gly Ser Asp Val
1 5 10
<210> 3551
<211> 12
<212> PRT
<213> Homo sapiens
<400> 3551
Ala Ala Trp Asp Ala Ser Leu Ser Gly His Val Val
1 5 10
<210> 3552
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3552
Met Gln Arg Ile Glu Phe Pro Trp Thr
1 5
<210> 3553
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3553
Gln Gln Tyr Tyr Thr Ala Pro Leu Thr
1 5
<210> 3554
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3554
Gln Gln Tyr Asn Ser Tyr Pro Trp Thr
1 5
<210> 3555
<211> 12
<212> PRT
<213> Homo sapiens
<400> 3555
Gln Ser Ala Asp Ser Ser Gly Thr Tyr Phe Trp Val
1 5 10
<210> 3556
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3556
Gln Gln Tyr Tyr Thr Ala Pro Leu Thr
1 5
<210> 3557
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3557
Ser Val Trp Asp Asp Ser Leu Asn Gly Pro Leu
1 5 10
<210> 3558
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3558
Gln Ser Ser Asp Ser Ser Gly Val Val
1 5
<210> 3559
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3559
Gln Gln Tyr Asn Ser Tyr Ser Trp Thr
1 5
<210> 3560
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3560
Ser Val Trp Asp Asp Ser Leu Asn Gly Pro Leu
1 5 10
<210> 3561
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3561
Gln Gln Ser Tyr Ser Thr Pro Pro Thr
1 5
<210> 3562
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3562
Gln Gln Ser Tyr Asn Thr Pro Arg Thr
1 5
<210> 3563
<211> 8
<212> PRT
<213> Homo sapiens
<400> 3563
Gln Gln Thr Asn Ser Phe Pro Thr
1 5
<210> 3564
<211> 8
<212> PRT
<213> Homo sapiens
<400> 3564
Gln Gln Tyr Gly Asn Ser Pro Gln
1 5
<210> 3565
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3565
Gln Gln Tyr Asn Ser Tyr Ser Thr Trp Thr
1 5 10
<210> 3566
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3566
Gln Gln Ser Tyr Asn Thr Pro Tyr Thr
1 5
<210> 3567
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3567
Ala Ala Trp Asp Asp Ser Leu Asn Ala Leu Val
1 5 10
<210> 3568
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3568
Gln Gln Ser Tyr Ser Thr Pro Gly Thr
1 5
<210> 3569
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3569
Gln Gln Ser Asp Asn Leu Pro Met Tyr Thr
1 5 10
<210> 3570
<211> 12
<212> PRT
<213> Homo sapiens
<400> 3570
Gln Val Trp Asp Ser Ser Ser Asp His His Val Val
1 5 10
<210> 3571
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3571
Leu Val Trp Asp Asp Ser Leu Asn Gly Leu Val
1 5 10
<210> 3572
<211> 12
<212> PRT
<213> Homo sapiens
<400> 3572
Gln Ser Tyr Asp Ser Arg Leu Ser Gly Phe Val Val
1 5 10
<210> 3573
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3573
Gln Gln Ser Tyr Thr Thr Leu Leu Thr
1 5
<210> 3574
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3574
Gln Gln Tyr Gly Ser Ser Pro Trp Thr
1 5
<210> 3575
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3575
Gln Ser Tyr Asp Ser Ser Leu Ser Asp Ser Val
1 5 10
<210> 3576
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3576
Gln Leu Leu Asn Ser His Pro Leu Thr
1 5
<210> 3577
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3577
Asn Ser Arg Asp Ser Ser Gly Asn Ala Val Val
1 5 10
<210> 3578
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3578
Gln Gln Tyr Ala Asn Leu Pro Phe Thr
1 5
<210> 3579
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3579
Asn Ser Arg Asp Ser Ser Gly Asn Ala Val Val
1 5 10
<210> 3580
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3580
Ala Val Trp Asp Asp Ser Leu Asn Gly Leu Val
1 5 10
<210> 3581
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3581
Gln Gln Ser Tyr Ser Thr Pro Trp Thr
1 5
<210> 3582
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3582
His Gln Tyr Asn Asn Trp Pro Gln Thr
1 5
<210> 3583
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3583
Gln Ser Tyr Asp Gly Ile Asn Arg Ala Trp Val
1 5 10
<210> 3584
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3584
Met Gln Ala Leu Gln Thr Pro Leu Thr
1 5
<210> 3585
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3585
Gln Gln Ser Tyr Ser Ser Leu Ser Ile Thr
1 5 10
<210> 3586
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3586
Gln Gln Ser Tyr Glu Ile Pro Pro Trp Thr
1 5 10
<210> 3587
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3587
Gln Gln Tyr Asp Asn Leu Pro Pro Val
1 5
<210> 3588
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3588
Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Val
1 5 10
<210> 3589
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3589
Gln Ser Tyr Asp Ser Gly Asn Pro Ile
1 5
<210> 3590
<211> 8
<212> PRT
<213> Homo sapiens
<400> 3590
Gln Gln Tyr Tyr Ser Thr Leu Thr
1 5
<210> 3591
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3591
Gln Gln Tyr Asp Asn Leu Pro Pro Val
1 5
<210> 3592
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3592
Gln Ser Tyr Asp Gly Ile Asn Arg Trp Leu Val
1 5 10
<210> 3593
<211> 14
<212> PRT
<213> Homo sapiens
<400> 3593
Gly Ala Asp His Gly Ser Gly Ser Asn Phe Glu Tyr Val Val
1 5 10
<210> 3594
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3594
Ala Ala Trp Asp Asp Ser Leu Asn Gly Tyr Val
1 5 10
<210> 3595
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3595
Gln Gln Leu Asn Ser Tyr Pro Val Thr
1 5
<210> 3596
<211> 12
<212> PRT
<213> Homo sapiens
<400> 3596
Ser Ser Tyr Thr Ser Ser Ser Thr Leu Leu Tyr Val
1 5 10
<210> 3597
<211> 12
<212> PRT
<213> Homo sapiens
<400> 3597
Gln Val Trp Asp Ser Ser Ser Asp His Pro Gly Val
1 5 10
<210> 3598
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3598
His Tyr Arg Ser Asn Trp Pro Pro Val Leu Thr
1 5 10
<210> 3599
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3599
Gln Gln Tyr Asp Asn Leu Tyr Ser Val His
1 5 10
<210> 3600
<211> 12
<212> PRT
<213> Homo sapiens
<400> 3600
Ser Ser Tyr Thr Ser Ser Ser Thr Leu Leu Tyr Val
1 5 10
<210> 3601
<211> 12
<212> PRT
<213> Homo sapiens
<400> 3601
Ser Ser Tyr Thr Ser Ser Ser Thr Leu Leu Tyr Val
1 5 10
<210> 3602
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3602
Gln Leu Leu Asn Ser His Pro Leu Thr
1 5
<210> 3603
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3603
Gln His Arg Thr Asn Trp Pro Pro Leu Phe Thr
1 5 10
<210> 3604
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3604
Gln Ala Trp Asp Ser Ser Thr Gly Val
1 5
<210> 3605
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3605
Gln Gln Tyr Asn Thr Tyr Ser Gly Thr
1 5
<210> 3606
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3606
Gln Ala Trp Asp Ser Ser Thr Gly Val
1 5
<210> 3607
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3607
Gln Gln Thr Tyr Ser Thr Phe Trp Thr
1 5
<210> 3608
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3608
Gln Ala Trp Asp Ser Ser Thr Ala Val
1 5
<210> 3609
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3609
Ser Ser Tyr Thr Ser Ser Arg Ala Val Leu
1 5 10
<210> 3610
<211> 13
<212> PRT
<213> Homo sapiens
<400> 3610
Gln Val Trp Asp Ser Ser Ser Asp His Pro Glu Trp Val
1 5 10
<210> 3611
<211> 8
<212> PRT
<213> Homo sapiens
<400> 3611
Gln Gln Ser Tyr Ser Thr Pro Thr
1 5
<210> 3612
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3612
Ser Ser Tyr Thr Ser Ser Ser Thr His Val Val
1 5 10
<210> 3613
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3613
Gln Gln Tyr Asn Thr Tyr Ser Gly Thr
1 5
<210> 3614
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3614
Gln Gln Tyr Tyr Thr Ala Pro Leu Thr
1 5
<210> 3615
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3615
Gln His Tyr Gly Ser Ser Arg Gly Trp Thr
1 5 10
<210> 3616
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3616
Gln Gln Tyr Gly Arg Ser Pro Ile Thr
1 5
<210> 3617
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3617
Gln Ala Trp Asp Ser Ser Thr Val Val
1 5
<210> 3618
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3618
Gln Gln Ser Tyr Ser Thr Pro Tyr Thr
1 5
<210> 3619
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3619
Gln Ser Tyr Asp Ser Ser Leu Gly Ala Leu
1 5 10
<210> 3620
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3620
Gln Gln Ala Asn Ser Phe Pro Pro Thr
1 5
<210> 3621
<211> 8
<212> PRT
<213> Homo sapiens
<400> 3621
Gln Gln Arg Gly Asn Trp Trp Thr
1 5
<210> 3622
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3622
Gln His Arg Thr Asn Trp Pro Pro Leu Phe Thr
1 5 10
<210> 3623
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3623
Gln Gln Cys Tyr Asn Trp Pro Pro Trp Thr
1 5 10
<210> 3624
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3624
His Lys Arg Ser Asn Trp Pro Pro Ser Leu Thr
1 5 10
<210> 3625
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3625
Gln Gln Tyr Tyr Ser Ile Ser Trp Thr
1 5
<210> 3626
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3626
Cys Ser Tyr Ala Val Ser Thr Thr Tyr Val Ile
1 5 10
<210> 3627
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3627
Gln Gln Tyr Tyr Ser Thr Pro Trp Thr
1 5
<210> 3628
<211> 14
<212> PRT
<213> Homo sapiens
<400> 3628
Gly Ala Asp His Gly Ser Gly Ser Asn Phe Val Phe Val Val
1 5 10
<210> 3629
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3629
Met Gln Ala Leu Gln Thr Pro Phe Thr
1 5
<210> 3630
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3630
Gln Gln Tyr Asn Tyr Trp Pro Pro Leu Thr
1 5 10
<210> 3631
<211> 12
<212> PRT
<213> Homo sapiens
<400> 3631
Gln Val Trp Asp Ser Ser Ser Asp His His Val Val
1 5 10
<210> 3632
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3632
Gln Gln Tyr Asn Thr Tyr Ser Gln Thr
1 5
<210> 3633
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3633
Gln Ala Trp Asp Asn Asp Ala Gly Val Val
1 5 10
<210> 3634
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3634
Gln Gln Tyr Asn Ser His Pro Pro Thr
1 5
<210> 3635
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3635
Ser Ala Tyr Ala Gly Ser Asn Asn Leu Val
1 5 10
<210> 3636
<211> 14
<212> PRT
<213> Homo sapiens
<400> 3636
Gly Ala Asp His Gly Ser Gly Ser Asn Phe Glu Tyr Val Val
1 5 10
<210> 3637
<211> 8
<212> PRT
<213> Homo sapiens
<400> 3637
Cys Ser Tyr Ala Gly Ile Val Leu
1 5
<210> 3638
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3638
Gln Ser Gly Asp Ser Ser Gly Thr Tyr Val Val
1 5 10
<210> 3639
<211> 13
<212> PRT
<213> Homo sapiens
<400> 3639
Gln Ser Val Asp Arg Ser Gly Thr Tyr Phe Asn Trp Val
1 5 10
<210> 3640
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3640
Gln Gln Ser Tyr Ser Thr Pro Tyr Thr
1 5
<210> 3641
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3641
Leu Leu Tyr Tyr Gly Gly Ala Trp Val
1 5
<210> 3642
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3642
Gln Ser Tyr Asp Gly Ser Asn His Ala Val Val
1 5 10
<210> 3643
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3643
Gln Val Trp Asp Ser Ser Ser Asp Pro Val Val
1 5 10
<210> 3644
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3644
Met Gln Ala Leu Gln Thr Pro Gln Thr
1 5
<210> 3645
<211> 8
<212> PRT
<213> Homo sapiens
<400> 3645
Gln Gln Tyr Gly Gly Ser Leu Thr
1 5
<210> 3646
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3646
Gln Ala Trp Asp Ser Ser Leu Val Val
1 5
<210> 3647
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3647
Ser Ser Tyr Thr Ser Ser Ser Leu Arg Val
1 5 10
<210> 3648
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3648
Gln Gln Leu Asn Ser Tyr Pro Val Thr
1 5
<210> 3649
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3649
Cys Ser Tyr Ala Gly Ser Tyr Thr Tyr Val
1 5 10
<210> 3650
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3650
Ser Ser Tyr Thr Ser Ser Ser Thr Leu Val Leu
1 5 10
<210> 3651
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3651
Gln Gln Arg Ser Asn Trp Pro Pro Ser Tyr Thr
1 5 10
<210> 3652
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3652
Ser Ser Tyr Thr Ser Ile Ser Thr Trp Val
1 5 10
<210> 3653
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3653
Phe Ser Met Asp Ser Ser Gly Asp Leu Arg Val
1 5 10
<210> 3654
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3654
Gln Gln Ser Tyr Ser Thr Pro Gly Leu Thr
1 5 10
<210> 3655
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3655
Ile Ser Tyr Thr Ser Ser Arg Thr Leu Val
1 5 10
<210> 3656
<211> 12
<212> PRT
<213> Homo sapiens
<400> 3656
Gln Val Trp Asp Ser Ser Tyr Tyr His Pro Val Val
1 5 10
<210> 3657
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3657
Leu Val Trp Asp Asp Ser Leu Asn Gly Leu Val
1 5 10
<210> 3658
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3658
Gly Thr Trp Asp Ser Ser Leu Ser Ala Val Val
1 5 10
<210> 3659
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3659
Gln Gln Tyr Ser Ile Tyr Ser Trp Thr
1 5
<210> 3660
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3660
Gln Gln Ser Tyr Ser Thr Pro Trp Thr
1 5
<210> 3661
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3661
Gln Gln Ala Asn Ser Leu Pro Leu Thr
1 5
<210> 3662
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3662
Ala Ala Trp Asp Asp Ser Leu Asn Gly Val Val
1 5 10
<210> 3663
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3663
Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val
1 5 10
<210> 3664
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3664
Gln Ala Trp Asp Ser Ser Thr Ala Val
1 5
<210> 3665
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3665
His Gln Tyr Asn Asn Trp Pro Gln Thr
1 5
<210> 3666
<211> 8
<212> PRT
<213> Homo sapiens
<400> 3666
Gln Gln Ser Tyr Ser Thr Leu Thr
1 5
<210> 3667
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3667
Gln His Arg Ser Asn Trp Pro Pro Arg Leu Thr
1 5 10
<210> 3668
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3668
Gln Gln Ser Tyr Ser Thr Pro Gly Thr
1 5
<210> 3669
<211> 8
<212> PRT
<213> Homo sapiens
<400> 3669
Gln Gln Tyr Gly Ser Ser Tyr Thr
1 5
<210> 3670
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3670
Gln Gln Thr Tyr Ser Thr Phe Trp Thr
1 5
<210> 3671
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3671
Ala Ala Trp Asp Asp Ser Leu Ser Ser Trp Val
1 5 10
<210> 3672
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3672
Gln Ser Tyr Asp Ser Gly Asn Pro Ile
1 5
<210> 3673
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3673
Gln Ala Trp Ser Ser Ser Thr Ala Val
1 5
<210> 3674
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3674
Ser Ser Tyr Thr Ser Ser Thr Leu Asn Val Leu
1 5 10
<210> 3675
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3675
Gln Gln Ser Tyr Ser Thr Pro Gly Thr
1 5
<210> 3676
<211> 12
<212> PRT
<213> Homo sapiens
<400> 3676
Gln Ser Tyr Asp Ser Ser Leu Ser Gly Trp Ser Val
1 5 10
<210> 3677
<211> 12
<212> PRT
<213> Homo sapiens
<400> 3677
Ser Ser Tyr Thr Ser Ser Ser Thr Leu Leu Tyr Val
1 5 10
<210> 3678
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3678
Gln Gln Ser Tyr Ser Thr His Met Ser Thr
1 5 10
<210> 3679
<211> 7
<212> PRT
<213> Homo sapiens
<400> 3679
Met Gln Ser Ile Gln Leu Ala
1 5
<210> 3680
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3680
Gln Gln Tyr Asn Tyr Trp Pro Pro Leu Thr
1 5 10
<210> 3681
<211> 12
<212> PRT
<213> Homo sapiens
<400> 3681
Ser Ser Gly Asp Ser Ser Thr Asp His His Val Val
1 5 10
<210> 3682
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3682
His Gln Ser Tyr Gly Val Pro Ile Thr
1 5
<210> 3683
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3683
Gln Gln Tyr Asn Asn Trp Pro Pro Met Tyr Thr
1 5 10
<210> 3684
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3684
Gln Ser Tyr Asp Ser Ser Lys Tyr Val Val
1 5 10
<210> 3685
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3685
Gln Gln Tyr Gly Ser Ser Pro Trp Thr
1 5
<210> 3686
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3686
Met Gln Ala Leu Gln Thr Pro Leu Tyr Thr
1 5 10
<210> 3687
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3687
Gln Gln Ser Tyr Ser Ser Leu Ser Ile Thr
1 5 10
<210> 3688
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3688
His Lys Arg Ser Asn Trp Pro Pro Ser Leu Thr
1 5 10
<210> 3689
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3689
Gln Ser Thr Ala Ser Ser Gly Thr Tyr Val Val
1 5 10
<210> 3690
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3690
Gln Gln Tyr Asn Ser Tyr Ser Pro Thr
1 5
<210> 3691
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3691
Gln Ser Tyr Asp Gly Ile Asn Arg Trp Leu Val
1 5 10
<210> 3692
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3692
Gln Gln Tyr Asn Asn Trp Pro Gly Thr
1 5
<210> 3693
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3693
Gln Gln Tyr Gly Ser Ser Pro Pro Tyr Thr
1 5 10
<210> 3694
<211> 14
<212> PRT
<213> Homo sapiens
<400> 3694
Gly Ala Asp His Gly Ser Gly Ser Asn Phe Val Tyr Val Val
1 5 10
<210> 3695
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3695
Gln His Phe Gly Ser Ser Ser Gln Trp Thr
1 5 10
<210> 3696
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3696
Leu Leu Tyr Tyr Gly Gly Pro Trp Val
1 5
<210> 3697
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3697
Gln Gln Tyr Asn Asn Trp Pro Leu Ala
1 5
<210> 3698
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3698
Cys Ser Tyr Ala Gly Gly Asn Thr Phe Val Val
1 5 10
<210> 3699
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3699
Gln Gln Tyr Asn Asn Trp Pro Arg Thr
1 5
<210> 3700
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3700
Ser Ser Tyr Thr Ser Ser Ser Thr Pro Val Val
1 5 10
<210> 3701
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3701
Met Gln Ala Leu Gln Thr Pro Arg Thr
1 5
<210> 3702
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3702
Gln Gln Ser Tyr Ser Thr Pro Trp Thr
1 5
<210> 3703
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3703
Ala Val Trp Asp Asp Ser Leu Asn Gly Leu Val
1 5 10
<210> 3704
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3704
Gln Gln Cys Tyr Asn Trp Pro Pro Trp Thr
1 5 10
<210> 3705
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3705
Gln Ala Trp Asp Ser Ser Thr Gly Val
1 5
<210> 3706
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3706
Gln Gln Tyr His Asn Leu Pro Arg Thr
1 5
<210> 3707
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3707
Gln Gln Leu Asn Ser Tyr Pro Phe Thr
1 5
<210> 3708
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3708
Gln Gln Tyr Tyr Ser Ile Ser Trp Thr
1 5
<210> 3709
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3709
Ser Ser Tyr Thr Ser Ser Ser Thr Leu Tyr Val
1 5 10
<210> 3710
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3710
Gln Lys Tyr Asn Ser Ala Pro Trp Thr
1 5
<210> 3711
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3711
Gln Ala Trp Asp Ser Ser Thr Gly Val
1 5
<210> 3712
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3712
Gln Gln Leu Asn Ser Tyr Pro Ile Thr
1 5
<210> 3713
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3713
Ala Val Trp Asp Asp Ser Leu Asn Gly Leu Val
1 5 10
<210> 3714
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3714
Ala Ala Trp Asp Asp Ser Leu Asn Gly Val Val
1 5 10
<210> 3715
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3715
Gln Gln Ser Tyr Thr Thr Leu Leu Thr
1 5
<210> 3716
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3716
Ser Ser Tyr Thr Ser Thr Ser Thr Pro Trp Val
1 5 10
<210> 3717
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3717
Gln Gln Tyr His Val Trp Pro Pro Ile Thr
1 5 10
<210> 3718
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3718
Gln Gln Tyr Tyr Ser Thr Pro Leu Thr
1 5
<210> 3719
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3719
Gln Gln Gly Asn Ser Phe Pro Leu Thr
1 5
<210> 3720
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3720
Gln Ser Tyr Asp Ser Ser Leu Ser Ala Trp Val
1 5 10
<210> 3721
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3721
Gln Gln Tyr Asn Thr Tyr Ser Gln Thr
1 5
<210> 3722
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3722
Gln Gln Arg Ser Asn Trp Pro Pro Gly Val Thr
1 5 10
<210> 3723
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3723
His Gln Tyr Asp Tyr Leu Pro Tyr Thr
1 5
<210> 3724
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3724
Gln Gln Thr Tyr Ser Thr Pro Leu Tyr Thr
1 5 10
<210> 3725
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3725
Gln His Arg Thr Asn Trp Pro Pro Leu Phe Thr
1 5 10
<210> 3726
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3726
Gln Ser Ala Asp Ser Ser Gly Thr Tyr Val Val
1 5 10
<210> 3727
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3727
Gln Gln Tyr Asn Thr Tyr Ser Gly Thr
1 5
<210> 3728
<211> 14
<212> PRT
<213> Homo sapiens
<400> 3728
Gly Ala Asp His Gly Ser Gly Ser Asn Phe Val Phe Val Val
1 5 10
<210> 3729
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3729
Gln Gln Tyr Tyr Ser Pro Pro Trp Thr
1 5
<210> 3730
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3730
Gln Gln Tyr His Asn Leu Pro Pro Ile Thr
1 5 10
<210> 3731
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3731
Gln Ala Trp Asp Ser Ser Thr Gly Gly Val
1 5 10
<210> 3732
<211> 13
<212> PRT
<213> Homo sapiens
<400> 3732
Gln Gln Tyr Asp Asn Leu Pro Pro Gly Val Ser Thr Thr
1 5 10
<210> 3733
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3733
Cys Ser Thr Asp Ser Ser Gly Asn Gln Arg Val
1 5 10
<210> 3734
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3734
Ser Ser Tyr Thr Ser Ser Ser Thr His Val Val
1 5 10
<210> 3735
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3735
Gln Ser Ala Asp Thr Ile Gly Thr Tyr Trp Val
1 5 10
<210> 3736
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3736
Gln Gln Tyr Asn Asn Trp Pro Pro Met Tyr Thr
1 5 10
<210> 3737
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3737
Gln Gln Tyr Asp Asn Leu Tyr Ser Val His
1 5 10
<210> 3738
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3738
Gln Gln Ser Tyr Glu Met Pro Pro Trp Thr
1 5 10
<210> 3739
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3739
Gln Ser Ala Asp Ser Ser Gly Tyr Val
1 5
<210> 3740
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3740
Ser Ser Tyr Thr Ser Ser Ser Ile Pro Tyr Val
1 5 10
<210> 3741
<211> 8
<212> PRT
<213> Homo sapiens
<400> 3741
Gln Gln Arg Gly Asn Trp Trp Thr
1 5
<210> 3742
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3742
Tyr Ser Thr Asp Thr Ser Gly Asn His Trp Val
1 5 10
<210> 3743
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3743
Tyr Ser Thr Asp Ser Ser Gly Asn His Arg Val
1 5 10
<210> 3744
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3744
His Gln Tyr Gly Thr Ser Pro Tyr Thr
1 5
<210> 3745
<211> 8
<212> PRT
<213> Homo sapiens
<400> 3745
Gln Gln Tyr Asn Asn Phe Leu Thr
1 5
<210> 3746
<211> 8
<212> PRT
<213> Homo sapiens
<400> 3746
Gln Gln Tyr Tyr Ser Thr Pro Gly
1 5
<210> 3747
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3747
Gln Ser Tyr Asp Ser Ser Leu Ser Asp Ser Val
1 5 10
<210> 3748
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3748
Gln Ser Ala Asp Ser Ser Gly Thr Ser Trp Val
1 5 10
<210> 3749
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3749
Gln Gln Tyr Gly Ser Ser Pro Phe Thr
1 5
<210> 3750
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3750
Gln Gln Tyr Asn Ser Tyr Ser Leu Thr
1 5
<210> 3751
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3751
Gln Gln Tyr Asn Asn Trp Trp Arg Thr
1 5
<210> 3752
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3752
Tyr Ser Thr Asp Ser Ser Gly Asn His Trp Val
1 5 10
<210> 3753
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3753
Asn Phe Arg Asp Ser Ser Gly His His Pro Val
1 5 10
<210> 3754
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3754
Ala Ala Trp Asp Asp Ser Leu Asn Ala Leu Val
1 5 10
<210> 3755
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3755
Gln Gln Tyr Asn Asn Trp Pro Gly Thr
1 5
<210> 3756
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3756
Tyr Ser Ala Ala Asp Asn Asn Arg Val
1 5
<210> 3757
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3757
Asn Ser Arg Asp Ser Ser Gly Asn Ala Val Val
1 5 10
<210> 3758
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3758
Gln Gln Tyr Asp Asn Leu Leu Leu Phe Thr
1 5 10
<210> 3759
<211> 12
<212> PRT
<213> Homo sapiens
<400> 3759
Gln Gln Arg Ser Asn Trp Pro Pro Arg Thr Trp Thr
1 5 10
<210> 3760
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3760
His Tyr Arg Ser Asn Trp Pro Pro Val Leu Thr
1 5 10
<210> 3761
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3761
Asn Ser Arg Asp Ser Ser Gly Asn Ala Val Val
1 5 10
<210> 3762
<211> 13
<212> PRT
<213> Homo sapiens
<400> 3762
Asn Ser Arg Asp Ser Ser Gly Tyr Ile Trp Gly Trp Met
1 5 10
<210> 3763
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3763
Gln Val Trp Asp Ser Ser Ser Asp His Trp Val
1 5 10
<210> 3764
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3764
Gln Ser Tyr Asp Ser Ser Leu Gly Ala Leu
1 5 10
<210> 3765
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3765
Gln Ser Trp Asp Thr Gly Ile Gly Val
1 5
<210> 3766
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3766
Gln Ala Trp Asp Ser Ser Thr Val Val
1 5
<210> 3767
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3767
Cys Ser Tyr Val Gly Ser Ser Thr Tyr Val Val
1 5 10
<210> 3768
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3768
Gln Ser Ala Asp Ser Ser Ser His Trp Val
1 5 10
<210> 3769
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3769
Gln Ser Phe Asp Ser Gly Asn Val Val
1 5
<210> 3770
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3770
Val Ala Trp Asp Asp Ser Arg Asn Gly Leu Val
1 5 10
<210> 3771
<211> 8
<212> PRT
<213> Homo sapiens
<400> 3771
Gln Gln Tyr Tyr Ser Thr Arg Thr
1 5
<210> 3772
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3772
Gln Gln Tyr Tyr Ser Thr Pro Pro Tyr Thr
1 5 10
<210> 3773
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3773
Leu Ala Trp Asp Asp Ser Leu Asn Gly Leu Val
1 5 10
<210> 3774
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3774
Ala Ala Trp Asp Ala Ser Leu Ser Gly Trp Val
1 5 10
<210> 3775
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3775
Gln Ser Val Asp Gly Ser Gly Ser Ser Val Val
1 5 10
<210> 3776
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3776
Gln Ala Trp Asp Ser Ser Thr His Val Val
1 5 10
<210> 3777
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3777
Ser Ser Tyr Thr Ser Ser Ser Thr Pro Phe Val
1 5 10
<210> 3778
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3778
Glu Thr Trp Asp Ser Asn Thr Arg Val
1 5
<210> 3779
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3779
Gln Gln Ser Tyr Ser Thr Pro Met His Thr
1 5 10
<210> 3780
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3780
Gln Gln Leu Asn Ser Tyr Leu Gly Thr
1 5
<210> 3781
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3781
Gln Gln Ala Asn Ser Phe Pro Pro Thr
1 5
<210> 3782
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3782
Leu Val Trp Asp Asp Ser Leu Asn Gly Leu Val
1 5 10
<210> 3783
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3783
Cys Ser Tyr Ala Gly Ser Ser Thr Trp Gly
1 5 10
<210> 3784
<211> 12
<212> PRT
<213> Homo sapiens
<400> 3784
Gln Val Trp Asp Ser Ser Ser Asp His His Val Val
1 5 10
<210> 3785
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3785
Met Gln Ala Leu Gln Thr Pro Leu Thr
1 5
<210> 3786
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3786
Gln Gln Tyr Asn Asn Trp Pro Pro Met Tyr Thr
1 5 10
<210> 3787
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3787
Gln Gln Tyr Asn Asn Trp Pro Arg Thr
1 5
<210> 3788
<211> 5
<212> PRT
<213> Homo sapiens
<400> 3788
Gln Thr Trp Gly Thr
1 5
<210> 3789
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3789
Met Gln Ser Ile Gln Pro Pro Leu Thr
1 5
<210> 3790
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3790
Gln Gln Tyr Tyr Ser Thr Pro Leu Thr
1 5
<210> 3791
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3791
Ser Ser Phe Thr Ser Arg Gly Ala Leu Val Leu
1 5 10
<210> 3792
<211> 8
<212> PRT
<213> Homo sapiens
<400> 3792
Cys Ser Tyr Ala Gly Ile Trp Val
1 5
<210> 3793
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3793
Gln His Tyr Gly Ser Ser Arg Ser Thr
1 5
<210> 3794
<211> 8
<212> PRT
<213> Homo sapiens
<400> 3794
Gln Gln Ser Tyr Ser Thr Pro Thr
1 5
<210> 3795
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3795
Gln Gln Ser Tyr Ser Thr Pro Tyr Thr
1 5
<210> 3796
<211> 12
<212> PRT
<213> Homo sapiens
<400> 3796
Asn Ser Arg Asp Ser Ser Gly Asn His Leu Arg Val
1 5 10
<210> 3797
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3797
Gln Gln Tyr Gly Arg Ser Pro Ile Thr
1 5
<210> 3798
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3798
Gln Gln Tyr Asp Asn Leu Leu Gln Phe Thr
1 5 10
<210> 3799
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3799
Tyr Ser Thr Asp Ser Ser Gly Asn Val
1 5
<210> 3800
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3800
Gln Gln Tyr Asn Ser Tyr Ser Leu Thr
1 5
<210> 3801
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3801
Gln Tyr Tyr Gly Ser Ser Pro Phe Gly
1 5
<210> 3802
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3802
Gln Gln Arg Ser Asn Trp Pro Pro Arg Leu Thr
1 5 10
<210> 3803
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3803
Ala Val Trp Asp Asp Ser Leu Asn Gly Val Val
1 5 10
<210> 3804
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3804
Leu Val Trp Asp Asp Ser Leu Asn Gly Leu Val
1 5 10
<210> 3805
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3805
Ser Ser Tyr Thr Ser Ser Arg Ala Val Leu
1 5 10
<210> 3806
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3806
Gln Gln Tyr Tyr Ser Ser His Trp Thr
1 5
<210> 3807
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3807
Tyr Ser Tyr Ala Gly Ser Ser Thr Trp Val
1 5 10
<210> 3808
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3808
Gln Ser Thr Asp Ser Ser Gly Ser Tyr Val Val
1 5 10
<210> 3809
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3809
His Gln Ser Tyr Phe Thr Pro Gln Thr
1 5
<210> 3810
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3810
Gln Gln Tyr Gly Asn Ser Pro Phe Thr
1 5
<210> 3811
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3811
Gln Gln Tyr Val Glu Pro Pro Phe Thr
1 5
<210> 3812
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3812
Ser Ala Tyr Ala Gly Ser Asn Asn Leu Val
1 5 10
<210> 3813
<211> 8
<212> PRT
<213> Homo sapiens
<400> 3813
Gln Gln Tyr Gly Ser Ser Tyr Thr
1 5
<210> 3814
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3814
Gln Gln Ser Tyr Ser Thr Pro Gly Thr
1 5
<210> 3815
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3815
Gln Gln Tyr Gly Arg Ser Ser Gly Thr
1 5
<210> 3816
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3816
Gln Gln Tyr Gly Ser Ser Pro Leu Ile Thr
1 5 10
<210> 3817
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3817
Gln Gln Tyr Tyr Thr Ala Pro Leu Thr
1 5
<210> 3818
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3818
Leu Leu Tyr Tyr Gly Gly Ala Trp Val
1 5
<210> 3819
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3819
His Gln Ser Ser Ser Leu Pro Pro Thr
1 5
<210> 3820
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3820
Gln Arg Arg Ser Asn Trp Pro Pro Phe Thr
1 5 10
<210> 3821
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3821
Gln Ser Tyr Asp Ser Ser Asn Tyr Trp Val
1 5 10
<210> 3822
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3822
Asn Ser Arg Asp Ser Ser Gly Asn Ala Val Val
1 5 10
<210> 3823
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3823
Gln Gln Tyr Tyr Ser Ser Pro Tyr Thr
1 5
<210> 3824
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3824
Gln Gln Tyr Asn Asn Trp Trp Arg Thr
1 5
<210> 3825
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3825
Gln Gln Tyr Gly Ser Ser Pro Arg Leu Thr
1 5 10
<210> 3826
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3826
Ala Val Trp Asp Asp Ser Leu Asn Gly Leu Val
1 5 10
<210> 3827
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3827
Gln Ser Tyr Asp Ser Ser Leu Asn Gly Asp Val
1 5 10
<210> 3828
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3828
Gln Gln Arg Ser Asn Trp Pro Leu Ile Phe Thr
1 5 10
<210> 3829
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3829
Gln Ser Tyr Asp Ser Ser Leu Ser Gly Tyr Val
1 5 10
<210> 3830
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3830
Gln Gln Ser Tyr Ser Thr Pro Pro Ile Thr
1 5 10
<210> 3831
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3831
Gln Gln Ser Tyr Ser Thr Pro Pro Trp Thr
1 5 10
<210> 3832
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3832
Gln Gln Tyr Ala Asn Leu Pro Phe Thr
1 5
<210> 3833
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3833
Val Ala Trp Asp Asp Ser Arg Asn Gly Leu Val
1 5 10
<210> 3834
<211> 13
<212> PRT
<213> Homo sapiens
<400> 3834
Gln Ser Val Asp Ser Ser Gly Thr Tyr Pro His Val Ile
1 5 10
<210> 3835
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3835
Gln Gln Ser Tyr Ser Thr Pro Tyr Thr
1 5
<210> 3836
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3836
Gln Gln Leu Asn Ser Tyr Pro Leu Thr
1 5
<210> 3837
<211> 12
<212> PRT
<213> Homo sapiens
<400> 3837
Thr Ser Tyr Thr Ser Ser Ser Thr Leu Asn Val Val
1 5 10
<210> 3838
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3838
Cys Ser Tyr Ala Ser Ser Ser Ile Val Val
1 5 10
<210> 3839
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3839
Gln Gln Ser Tyr Ser Thr Pro Pro Trp Thr
1 5 10
<210> 3840
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3840
Gln Gln Leu Asn Ser Tyr Ser Phe Glu Thr
1 5 10
<210> 3841
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3841
Gln Ser Tyr Asp Gly Ile Asn Arg Trp Leu Val
1 5 10
<210> 3842
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3842
Gln Gln Tyr Asn Ser Tyr Pro Tyr Thr
1 5
<210> 3843
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3843
Gln Gln Ser Ser Ser Ser Pro Ile Thr
1 5
<210> 3844
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3844
Gln Gln Ser Tyr Thr Thr Leu Leu Thr
1 5
<210> 3845
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3845
Gln Val Trp Asp Gly Ile Asn Asp Arg Val Val
1 5 10
<210> 3846
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3846
Gln Gln Tyr Asp Asn Leu Pro Pro Val
1 5
<210> 3847
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3847
Gln Gln Ser Tyr Ser Ser Glu Trp Thr
1 5
<210> 3848
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3848
Gln Ser Tyr Asp Ile Ser Leu Gly Gly Trp Val
1 5 10
<210> 3849
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3849
Gln Gln Ser Tyr Ser Met Pro Pro Ile Thr
1 5 10
<210> 3850
<211> 12
<212> PRT
<213> Homo sapiens
<400> 3850
Ala Ala Trp Asp Asp Ser Leu Asn Gly Ser Trp Val
1 5 10
<210> 3851
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3851
Ala Ala Trp Asp Asp Ser Leu Ser Gly Leu Ile
1 5 10
<210> 3852
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3852
Cys Ser Tyr Ala Gly Ser Ser Thr Trp Leu
1 5 10
<210> 3853
<211> 12
<212> PRT
<213> Homo sapiens
<400> 3853
Gln Val Trp Asp Ser Ser Ser Asp His His Val Val
1 5 10
<210> 3854
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3854
Val Ala Trp Asp Asp Ser Arg Asn Gly Leu Val
1 5 10
<210> 3855
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3855
Gly Thr Trp Asp Ser Ser Leu Ser Ala Tyr Val
1 5 10
<210> 3856
<211> 12
<212> PRT
<213> Homo sapiens
<400> 3856
Gln Val Trp Asp Ser Ser Ser Asp His Pro Gly Val
1 5 10
<210> 3857
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3857
Gln Ala Trp Gly Ser Ser Arg Gly Val
1 5
<210> 3858
<211> 12
<212> PRT
<213> Homo sapiens
<400> 3858
Asn Ser Arg Asp Asn Ser Gly Asn Leu Asn Trp Val
1 5 10
<210> 3859
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3859
Gln Gln Tyr Asp Asn Leu Pro Tyr Thr
1 5
<210> 3860
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3860
Gln Ser Ala Asp Ser Ser Gly Ser Arg
1 5
<210> 3861
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3861
Gln Gln Tyr Asn Asn Trp Pro Tyr Thr
1 5
<210> 3862
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3862
Gln Gln Ser Tyr Glu Ile Pro Pro Trp Thr
1 5 10
<210> 3863
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3863
Ala Thr Trp Asp Asp Ser Leu Asn Gly Pro Val
1 5 10
<210> 3864
<211> 12
<212> PRT
<213> Homo sapiens
<400> 3864
Gln Ser Tyr Asp Ser Arg Leu Ser Gly Phe Val Val
1 5 10
<210> 3865
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3865
Gln Ser Ala Asp Ser Ser Gly Thr Ser Val Leu
1 5 10
<210> 3866
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3866
Cys Ser Tyr Ala Arg Ser Ser Thr Arg Val
1 5 10
<210> 3867
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3867
Gln Ser Ala Asp Ser Arg Gly Ala Val
1 5
<210> 3868
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3868
Ala Val Trp Asp Asp Ser Leu His Ser Tyr Val
1 5 10
<210> 3869
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3869
Gln Gln Ser Tyr Ser Thr Pro Arg Thr
1 5
<210> 3870
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3870
Gln Gln Tyr Asp Asn Leu Pro Leu Ala
1 5
<210> 3871
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3871
Gln Gln Ser Tyr Thr Thr Leu Leu Thr
1 5
<210> 3872
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3872
Gln Ser Tyr Asp Ser Ser Leu Ser Gly Trp Val
1 5 10
<210> 3873
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3873
Gln Gln Tyr Ala Asn Leu Pro Phe Thr
1 5
<210> 3874
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3874
Gln Gln Tyr Asp Asn Leu Pro Arg Thr
1 5
<210> 3875
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3875
Gln Ser Tyr Asp Ser Ser Leu Ser Gly Tyr Val
1 5 10
<210> 3876
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3876
Cys Ser Tyr Ala Val Ser Thr Thr Tyr Val Ile
1 5 10
<210> 3877
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3877
Gln Gln Ser Tyr Ser Asn Pro Ser Tyr Thr
1 5 10
<210> 3878
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3878
Gln Gln Tyr Gly Ser Ser Pro Pro Arg Tyr Thr
1 5 10
<210> 3879
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3879
Gln Gln Ser Tyr Ser Thr Leu Leu Tyr Thr
1 5 10
<210> 3880
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3880
Met Gln Ala Leu Gln Thr Pro Phe Thr
1 5
<210> 3881
<211> 12
<212> PRT
<213> Homo sapiens
<400> 3881
Gln Val Trp Asp Ser Ser Ser Asp Arg Leu Tyr Val
1 5 10
<210> 3882
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3882
Gln Gln Ser Tyr Ser Asn Pro Ser Tyr Thr
1 5 10
<210> 3883
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3883
Cys Ser Tyr Ala Gly Ser Ser Thr Trp Leu
1 5 10
<210> 3884
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3884
Gln Ser Tyr Asp Ser Thr Ser Arg Val Val
1 5 10
<210> 3885
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3885
Gln Val Trp Asp Ser Gly Ser Asp His Val Val
1 5 10
<210> 3886
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3886
Gln Gln Ser Tyr Ser Thr Pro Gln Thr
1 5
<210> 3887
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3887
Ala Ser Trp Asp Asp Ser Leu Ile Gly Pro Val
1 5 10
<210> 3888
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3888
Gln Gln Leu Asn Ser Tyr Pro Gly Tyr Thr
1 5 10
<210> 3889
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3889
Gln Ser Tyr Asp Ser Asn Asn Gln Val
1 5
<210> 3890
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3890
Gln Ser Tyr Asp Ser Ser Asp Val Val
1 5
<210> 3891
<211> 12
<212> PRT
<213> Homo sapiens
<400> 3891
Gln Val Trp Asp Ser Ser Ser Asp His His Val Val
1 5 10
<210> 3892
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3892
Gln Ser Ala Asp Ser Ser Gly Thr Tyr Arg Val
1 5 10
<210> 3893
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3893
Gln Gln Tyr Tyr Asn Trp Pro Leu Thr
1 5
<210> 3894
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3894
Gln Ser Ala Asp Ser Ser Ala Ala Tyr Val Val
1 5 10
<210> 3895
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3895
Tyr Ser Thr Asp Ser Ser Gly Lys Gly Val
1 5 10
<210> 3896
<211> 12
<212> PRT
<213> Homo sapiens
<400> 3896
Gln Val Trp Asp Ser Ser Ser Asp Pro Phe Tyr Val
1 5 10
<210> 3897
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3897
Gln Ser Tyr Asp Gly Ile Asn Arg Ala Trp Val
1 5 10
<210> 3898
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3898
Gln Gln Tyr Tyr Ser Thr Pro Trp Thr
1 5
<210> 3899
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3899
Gln Gln Tyr Asn Ser Tyr Ser Tyr Thr
1 5
<210> 3900
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3900
Gln Gln Tyr Asp Asp Trp Pro Pro Glu Val Thr
1 5 10
<210> 3901
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3901
Val Ala Trp Asp Asp Ser Arg Asn Gly Leu Val
1 5 10
<210> 3902
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3902
Gln Ser Phe Asp Ile Gly Arg Gly Gly Trp Ile
1 5 10
<210> 3903
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3903
Gln Gln Ser Tyr Ser Thr Pro Pro Thr
1 5
<210> 3904
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3904
Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Val
1 5 10
<210> 3905
<211> 8
<212> PRT
<213> Homo sapiens
<400> 3905
Cys Ser Tyr Ala Gly Ser Val Leu
1 5
<210> 3906
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3906
Gln Gln Ser Phe Ser Thr Pro Arg Thr
1 5
<210> 3907
<211> 13
<212> PRT
<213> Homo sapiens
<400> 3907
Gln Val Trp Asp Ser Ser Ser Asp His Pro Glu Trp Val
1 5 10
<210> 3908
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3908
Met Gln Ala Leu Gln Thr Pro Trp Thr
1 5
<210> 3909
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3909
Asn Ser Arg Asp Ser Ser Gly Asn Pro Arg Trp
1 5 10
<210> 3910
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3910
Gln Gln Tyr Gly Ser Ser Pro Pro Arg Tyr Thr
1 5 10
<210> 3911
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3911
Gln Ser Val Asp Ser Ser Gly Thr Tyr Arg Val
1 5 10
<210> 3912
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3912
Gln Gln Tyr Asp Asn Leu Pro Leu Ala
1 5
<210> 3913
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3913
Met Gln Gly Thr His Trp Pro Tyr Thr
1 5
<210> 3914
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3914
Cys Ser Tyr Ala Gly Arg Tyr Thr Trp Val
1 5 10
<210> 3915
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3915
Gln Leu Leu Asn Ser His Pro Leu Thr
1 5
<210> 3916
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3916
Gln Ser Ala Asp Ser Thr Gly Trp Val
1 5
<210> 3917
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3917
Met Gln Ser Ile Gln Leu Pro Tyr Thr
1 5
<210> 3918
<211> 7
<212> PRT
<213> Homo sapiens
<400> 3918
Met Gln Ser Ile Gln Leu Ala
1 5
<210> 3919
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3919
Gln His Tyr Gly Ser Ser Arg Gly Trp Thr
1 5 10
<210> 3920
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3920
Gln Gln Tyr Tyr Asn Trp Pro Leu Thr
1 5
<210> 3921
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3921
Gln Gln Tyr Asn Ser Tyr Pro Tyr Thr
1 5
<210> 3922
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3922
Gln Gln Ser Tyr Glu Ile Pro Pro Trp Thr
1 5 10
<210> 3923
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3923
Gln Gln Tyr Ala Asn Leu Pro Phe Thr
1 5
<210> 3924
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3924
Gln His Tyr Gly Ser Ser Arg Gly Trp Thr
1 5 10
<210> 3925
<211> 13
<212> PRT
<213> Homo sapiens
<400> 3925
Gln Ser Val Asp Ser Ser Gly Thr Tyr Pro His Val Ile
1 5 10
<210> 3926
<211> 12
<212> PRT
<213> Homo sapiens
<400> 3926
Gln Ser Tyr Ala Ser Ser Leu Ser Ala His Val Val
1 5 10
<210> 3927
<211> 8
<212> PRT
<213> Homo sapiens
<400> 3927
Gln Gln Tyr Tyr Ser Ser Tyr Thr
1 5
<210> 3928
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3928
Gln Gln Tyr Gly Ser Ser Pro Pro Pro Phe Thr
1 5 10
<210> 3929
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3929
Ser Ser Tyr Thr Ser Ser Ser Thr Pro Val Val
1 5 10
<210> 3930
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3930
Gln Lys Tyr Asn Ser Ala Pro Pro Ala
1 5
<210> 3931
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3931
Gln Ala Trp Gly Ser Thr Thr Ala Lys Val
1 5 10
<210> 3932
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3932
Gln Gln Arg Ser Asn Trp Pro Pro Arg Val Thr
1 5 10
<210> 3933
<211> 12
<212> PRT
<213> Homo sapiens
<400> 3933
Ser Ser Tyr Thr Ser Ser Ser Thr Arg His Trp Val
1 5 10
<210> 3934
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3934
Gln Gln Ser Tyr Ser Thr Pro Tyr Thr
1 5
<210> 3935
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3935
Ser Ala Tyr Thr Thr Thr Ser Thr Ser Trp Val
1 5 10
<210> 3936
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3936
Ser Ser Tyr Val Gly Asn Asn Asn Trp Val
1 5 10
<210> 3937
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3937
Gln Gln Tyr Asp Asn Pro Pro Leu Thr
1 5
<210> 3938
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3938
Leu Leu Ser Tyr Ser Gly Val Trp Val
1 5
<210> 3939
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3939
Gln Gln Tyr Asn Asn Trp Pro Pro Trp Thr
1 5 10
<210> 3940
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3940
Gln Val Trp Asp Ser Ser Ser Asp His Trp Val
1 5 10
<210> 3941
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3941
Gln Gln Tyr Asn Asn Trp Pro Pro Gly Thr
1 5 10
<210> 3942
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3942
Gln Ala Trp Asp Ser Ser Thr Ala Val
1 5
<210> 3943
<211> 12
<212> PRT
<213> Homo sapiens
<400> 3943
Gln Ser Ala Asp Ser Ser Gly Thr Tyr Ser Val Val
1 5 10
<210> 3944
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3944
Gln Gln Tyr Asn Ser Tyr Ser Ile Thr
1 5
<210> 3945
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3945
Gln Gln Leu His Ser Tyr Pro Leu Thr
1 5
<210> 3946
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3946
Gln Gln Tyr Gly Ser Ser Pro Leu Phe Thr
1 5 10
<210> 3947
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3947
Gln Gln Ser Tyr Ser Thr Pro Pro Val Thr
1 5 10
<210> 3948
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3948
Gln Gln Ser Tyr Ser Thr His Met Ser Thr
1 5 10
<210> 3949
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3949
Gln Gln Arg Ser Asn Trp Pro Gln Val Thr
1 5 10
<210> 3950
<211> 8
<212> PRT
<213> Homo sapiens
<400> 3950
Gln Gln Tyr Gly Ser Leu Tyr Thr
1 5
<210> 3951
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3951
Gln Gln Tyr Asp Asn Leu Pro Leu Thr
1 5
<210> 3952
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3952
Gln Gln Tyr Gly Ser Ser Pro Gly Thr
1 5
<210> 3953
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3953
Gln Gln Tyr Gly Ser Ser Leu Leu Thr
1 5
<210> 3954
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3954
Gln Gln Tyr Gly Ser Ser Pro Arg Leu Thr
1 5 10
<210> 3955
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3955
Gln Gln Tyr Asn Asn Trp Pro Pro Trp Thr
1 5 10
<210> 3956
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3956
Gln Gln Tyr Gly Ser Ser Pro Gly Thr
1 5
<210> 3957
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3957
Gln Gln Arg Ser Asn Trp Pro Pro Met Tyr Thr
1 5 10
<210> 3958
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3958
Met Gln Gly Thr His Trp Pro Arg Thr
1 5
<210> 3959
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3959
Leu Gln His Asn Ser Tyr Pro Pro Leu
1 5
<210> 3960
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3960
Gln Gln Arg Ser Asn Trp Pro Pro Tyr Thr
1 5 10
<210> 3961
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3961
Gln Gln Arg Ser Asn Trp Pro Pro Ser Ile Thr
1 5 10
<210> 3962
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3962
Leu Gln His Asn Ser Tyr Leu Trp Thr
1 5
<210> 3963
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3963
Gln Gln Tyr Asp Asn Leu Pro Ile Thr
1 5
<210> 3964
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3964
Gln Gln Tyr Gly Ser Ser Pro Gly Val Thr
1 5 10
<210> 3965
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3965
Gln Gln Ser Tyr Ser Thr Pro Gln Thr
1 5
<210> 3966
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3966
Ser Ser Tyr Thr Ser Ser Ser Thr Trp Val
1 5 10
<210> 3967
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3967
Gln Ala Trp Asp Ser Ser Thr Ala Val Val
1 5 10
<210> 3968
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3968
Gln Gln Tyr Asn Tyr Trp Pro Leu Ile Thr
1 5 10
<210> 3969
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3969
Gln Gln Ser Tyr Ser Thr Pro Arg Thr
1 5
<210> 3970
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3970
Gln Val Trp Ala Ser Ser Ser Val Val
1 5
<210> 3971
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3971
Met Gln Ser Ile Gln Leu Pro Pro Thr
1 5
<210> 3972
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3972
Gln Gln Arg Ser Asn Trp Pro Pro Arg Leu Thr
1 5 10
<210> 3973
<211> 7
<212> PRT
<213> Homo sapiens
<400> 3973
Cys Ser Tyr Ala Gly Ser Val
1 5
<210> 3974
<211> 13
<212> PRT
<213> Homo sapiens
<400> 3974
Ser Ser Tyr Thr Ser Ser Ser Thr Leu Gly Leu Tyr Val
1 5 10
<210> 3975
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3975
Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Val
1 5 10
<210> 3976
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3976
Leu Gln His Asn Ser Tyr Pro Leu Thr
1 5
<210> 3977
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3977
Cys Ser Tyr Ala Gly Ser Ser Thr Trp Val
1 5 10
<210> 3978
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3978
Cys Ser Tyr Ala Gly Ser Ser Thr Trp Val
1 5 10
<210> 3979
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3979
Gln Gln Cys Tyr Asn Trp Pro Pro Trp Thr
1 5 10
<210> 3980
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3980
Leu Gln His Asn Ser Tyr Pro Leu Thr
1 5
<210> 3981
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3981
Gln Gln Ser Tyr Thr Thr Phe Ile Tyr Thr
1 5 10
<210> 3982
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3982
Gln Gln Tyr Gly Ser Ser Pro Tyr Thr
1 5
<210> 3983
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3983
Gln Gln Tyr Asp Asn Leu Leu Ser Leu Thr
1 5 10
<210> 3984
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3984
Gln Gln Tyr Tyr Ser Thr Pro Pro Leu Thr
1 5 10
<210> 3985
<211> 8
<212> PRT
<213> Homo sapiens
<400> 3985
Gln Gln Ser Tyr Ser Thr Leu Thr
1 5
<210> 3986
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3986
Gln Ser Ala Asp Ser Ser Gly Thr Tyr Arg Val
1 5 10
<210> 3987
<211> 11
<212> PRT
<213> Homo sapiens
<400> 3987
Gln Val Trp Asp Ser Ser Ser Asp His Tyr Val
1 5 10
<210> 3988
<211> 13
<212> PRT
<213> Homo sapiens
<400> 3988
Ala Ala Trp Asp Asp Ser Leu Asn Gly Pro His Trp Val
1 5 10
<210> 3989
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3989
Gln Gln Tyr Tyr Ser Thr Pro Leu Thr
1 5
<210> 3990
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3990
Gln Gln Tyr Gly Ser Ser Pro Phe Thr
1 5
<210> 3991
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3991
Gln Gln Ser Tyr Ser Thr Pro Leu Thr
1 5
<210> 3992
<211> 8
<212> PRT
<213> Homo sapiens
<400> 3992
Gln Gln Ser Tyr Ser Thr Leu Thr
1 5
<210> 3993
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3993
Gln Gln Tyr Tyr Ser Thr Pro Ile Thr
1 5
<210> 3994
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3994
Gln Gln Tyr Tyr Ser Thr Pro Tyr Thr
1 5
<210> 3995
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3995
Gln Gln Ala Asn Gly Phe Pro Pro Leu
1 5
<210> 3996
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3996
Gln Gln Ser Tyr Ser Thr Pro Tyr Thr
1 5
<210> 3997
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3997
Gln Gln Arg Ser Asn Trp Pro Pro Val Thr
1 5 10
<210> 3998
<211> 10
<212> PRT
<213> Homo sapiens
<400> 3998
Ser Ser Tyr Thr Ser Ser Ser Thr Tyr Val
1 5 10
<210> 3999
<211> 9
<212> PRT
<213> Homo sapiens
<400> 3999
Gln Gln Tyr Asp Asn Leu Pro Leu Thr
1 5
<210> 4000
<211> 11
<212> PRT
<213> Homo sapiens
<400> 4000
Cys Ser Tyr Ala Gly Gly Ser Thr Ser Tyr Val
1 5 10
<210> 4001
<211> 10
<212> PRT
<213> Homo sapiens
<400> 4001
Ser Ser Tyr Ala Gly Asn Asn Asp Phe Val
1 5 10
<210> 4002
<211> 10
<212> PRT
<213> Homo sapiens
<400> 4002
Cys Ser Tyr Ala Gly His Ser Thr Trp Val
1 5 10
<210> 4003
<211> 10
<212> PRT
<213> Homo sapiens
<400> 4003
Cys Ser Tyr Ala Gly Thr Ser Thr Phe Val
1 5 10
<210> 4004
<211> 10
<212> PRT
<213> Homo sapiens
<400> 4004
Cys Ser Tyr Ala Gly Ser Ser Ser Trp Val
1 5 10
<210> 4005
<211> 10
<212> PRT
<213> Homo sapiens
<400> 4005
Ser Ser Tyr Thr Ser Ser Ser Thr Tyr Val
1 5 10
<210> 4006
<211> 10
<212> PRT
<213> Homo sapiens
<400> 4006
Gln Gln Tyr Tyr Gly Ser Ser Pro Trp Thr
1 5 10
<210> 4007
<211> 8
<212> PRT
<213> Homo sapiens
<400> 4007
Gln Gln Ser Tyr Ser Thr His Ala
1 5
<210> 4008
<211> 11
<212> PRT
<213> Homo sapiens
<400> 4008
Ala Ala Trp Asp Asp Ser Leu Asn Gly Pro Val
1 5 10
<210> 4009
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4009
Gln Gln Tyr Ala Gly Ser Pro Trp Thr
1 5
<210> 4010
<211> 11
<212> PRT
<213> Homo sapiens
<400> 4010
Gln Gln Arg Ser Asn Trp Pro Pro Ile Phe Thr
1 5 10
<210> 4011
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4011
Met Gln Gly Thr His Trp Pro Val Thr
1 5
<210> 4012
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4012
Gln Gln Ser Tyr Ser Asn Pro Leu Thr
1 5
<210> 4013
<211> 10
<212> PRT
<213> Homo sapiens
<400> 4013
Cys Ser Tyr Ala Gly Ser Tyr Thr Trp Val
1 5 10
<210> 4014
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4014
Gln Gln Tyr Gly Ser Ser Arg Gly Thr
1 5
<210> 4015
<211> 10
<212> PRT
<213> Homo sapiens
<400> 4015
Cys Ser Tyr Ala Gly Ser Ser Thr Tyr Val
1 5 10
<210> 4016
<211> 12
<212> PRT
<213> Homo sapiens
<400> 4016
Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Pro Val
1 5 10
<210> 4017
<211> 11
<212> PRT
<213> Homo sapiens
<400> 4017
Gln Gln Tyr Gly Ser Ser Pro Pro Lys Tyr Thr
1 5 10
<210> 4018
<211> 11
<212> PRT
<213> Homo sapiens
<400> 4018
Gln Gln Tyr Asn Asn Trp Pro Pro Ser Leu Thr
1 5 10
<210> 4019
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4019
Gln Gln Arg Ser Asn Trp Pro Leu Thr
1 5
<210> 4020
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4020
Gln Thr Trp Gly Thr Gly Ile Arg Val
1 5
<210> 4021
<211> 11
<212> PRT
<213> Homo sapiens
<400> 4021
Gln Ser Ala Asp Ser Ser Gly Thr Tyr Val Val
1 5 10
<210> 4022
<211> 12
<212> PRT
<213> Homo sapiens
<400> 4022
Gly Thr Trp Asp Ser Ser Leu Ser Ala Ser Tyr Val
1 5 10
<210> 4023
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4023
Gln Gln Tyr Asn Asn Trp Pro Tyr Thr
1 5
<210> 4024
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4024
Leu Gln His Asn Ser Tyr Pro Phe Thr
1 5
<210> 4025
<211> 11
<212> PRT
<213> Homo sapiens
<400> 4025
Ser Ser Tyr Thr Ser Ser Ser Thr Pro Tyr Val
1 5 10
<210> 4026
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4026
Gln Gln Ser Tyr Ser Asn Pro Leu Thr
1 5
<210> 4027
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4027
Gln Gln Tyr Gly Ser Ser Pro Gln Thr
1 5
<210> 4028
<211> 12
<212> PRT
<213> Homo sapiens
<400> 4028
Gly Thr Trp Asp Ser Ser Leu Ser Ala Ser Tyr Val
1 5 10
<210> 4029
<211> 11
<212> PRT
<213> Homo sapiens
<400> 4029
Gly Thr Trp Asp Ser Ser Leu Ser Ala Val Val
1 5 10
<210> 4030
<211> 12
<212> PRT
<213> Homo sapiens
<400> 4030
Gln Ser Tyr Asp Ser Ser Leu Ser Gly Pro Val Val
1 5 10
<210> 4031
<211> 11
<212> PRT
<213> Homo sapiens
<400> 4031
Gln Val Trp Asp Ser Ser Ser Asp His Val Val
1 5 10
<210> 4032
<211> 11
<212> PRT
<213> Homo sapiens
<400> 4032
Ala Ala Trp Asp Asp Ser Leu Asn Gly Pro Val
1 5 10
<210> 4033
<211> 11
<212> PRT
<213> Homo sapiens
<400> 4033
Gln Ser Ala Asp Ser Ser Gly Thr Tyr Met Ile
1 5 10
<210> 4034
<211> 8
<212> PRT
<213> Homo sapiens
<400> 4034
Gln Gln Tyr Asp Asn Leu Pro Arg
1 5
<210> 4035
<211> 10
<212> PRT
<213> Homo sapiens
<400> 4035
Gln Gln Arg Ser Asn Trp Pro Pro Ile Thr
1 5 10
<210> 4036
<211> 10
<212> PRT
<213> Homo sapiens
<400> 4036
Gln Gln Tyr Asp Asn Leu Pro Ser Trp Thr
1 5 10
<210> 4037
<211> 10
<212> PRT
<213> Homo sapiens
<400> 4037
Gln Gln Leu Asn Ser Tyr Pro Pro Gly Thr
1 5 10
<210> 4038
<211> 11
<212> PRT
<213> Homo sapiens
<400> 4038
Gln Gln Ser Tyr Ser Thr Pro Arg Gln Trp Thr
1 5 10
<210> 4039
<211> 11
<212> PRT
<213> Homo sapiens
<400> 4039
Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Val
1 5 10
<210> 4040
<211> 5
<212> PRT
<213> Homo sapiens
<400> 4040
Gln Gln Leu Tyr Thr
1 5
<210> 4041
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4041
Met Gln Gly Thr His Trp Pro Val Thr
1 5
<210> 4042
<211> 7
<212> PRT
<213> Homo sapiens
<400> 4042
Gln Gln Tyr Asn Ser Tyr Thr
1 5
<210> 4043
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4043
Leu Gln His Asn Ser Tyr Pro Leu Thr
1 5
<210> 4044
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4044
Gln Gln Tyr Asn Asn Trp Pro Leu Thr
1 5
<210> 4045
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4045
Gln Gln Thr Tyr Ile Thr Ala Phe Thr
1 5
<210> 4046
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4046
Gln Ser Tyr Asp Ser Ser Asn Trp Val
1 5
<210> 4047
<211> 11
<212> PRT
<213> Homo sapiens
<400> 4047
Gln Ser Ala Asp Ser Ser Gly Thr Tyr Val Val
1 5 10
<210> 4048
<211> 11
<212> PRT
<213> Homo sapiens
<400> 4048
Gln Ser Tyr Asp Ser Ser Leu Thr Leu Tyr Val
1 5 10
<210> 4049
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4049
Met Gln Gly Thr His Trp Pro Val Thr
1 5
<210> 4050
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4050
Leu Gln His Asn Ser Tyr Pro Leu Thr
1 5
<210> 4051
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4051
Met Gln Gly Thr His Trp Pro Pro Thr
1 5
<210> 4052
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4052
Gln Gln Tyr Tyr Ile Thr Pro Tyr Thr
1 5
<210> 4053
<211> 11
<212> PRT
<213> Homo sapiens
<400> 4053
Tyr Ser Thr Asp Ser Ser Gly Asn Leu Tyr Val
1 5 10
<210> 4054
<211> 7
<212> PRT
<213> Homo sapiens
<400> 4054
Gln Gln Tyr Asn Ser Tyr Thr
1 5
<210> 4055
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4055
Gln Gln Tyr Gly Ser Ser Pro Gly Thr
1 5
<210> 4056
<211> 10
<212> PRT
<213> Homo sapiens
<400> 4056
Ser Ser Tyr Thr Ser Ile Ser Thr Trp Val
1 5 10
<210> 4057
<211> 10
<212> PRT
<213> Homo sapiens
<400> 4057
Gln Gln Ser Tyr Ser Thr Leu Ala Leu Thr
1 5 10
<210> 4058
<211> 10
<212> PRT
<213> Homo sapiens
<400> 4058
Ser Ser Tyr Ala Gly Ser Asn Asn Leu Val
1 5 10
<210> 4059
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4059
Gln Gln Tyr Gly Ser Ser Pro Gly Thr
1 5
<210> 4060
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4060
Gln Gln Tyr Asp Asn Leu Pro Leu Thr
1 5
<210> 4061
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4061
Gln Gln Tyr Asp Asn Leu Pro Leu Thr
1 5
<210> 4062
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4062
Met Gln Arg Ile Glu Phe Pro Leu Thr
1 5
<210> 4063
<211> 11
<212> PRT
<213> Homo sapiens
<400> 4063
Gln Gln Arg Ser Asn Trp Pro Pro Thr Trp Thr
1 5 10
<210> 4064
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4064
Gln Gln Tyr Gly Ser Ser Pro Trp Thr
1 5
<210> 4065
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4065
Gln His Tyr His Ser Phe Pro Leu Thr
1 5
<210> 4066
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4066
Gln Gln Tyr Gly Ser Ser Pro Arg Thr
1 5
<210> 4067
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4067
Gln Gln Tyr Gly Ser Ser Pro Arg Thr
1 5
<210> 4068
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4068
Gln Gln Tyr Gly Arg Ser Pro Trp Thr
1 5
<210> 4069
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4069
Gln Gln Ser Tyr Ser Asn Pro Leu Thr
1 5
<210> 4070
<211> 12
<212> PRT
<213> Homo sapiens
<400> 4070
Gln Ser Tyr Asp Ser Ser Leu Ser Val Leu Tyr Val
1 5 10
<210> 4071
<211> 10
<212> PRT
<213> Homo sapiens
<400> 4071
Gln Gln Tyr Asn Ser Trp Pro Pro Leu Thr
1 5 10
<210> 4072
<211> 8
<212> PRT
<213> Homo sapiens
<400> 4072
Gln Arg Arg Gly Asp Gly Tyr Asn
1 5
<210> 4073
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4073
Met Gln Gly Thr Glu Trp Pro Arg Thr
1 5
<210> 4074
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4074
Met Gln Gly Thr Glu Trp Pro Arg Thr
1 5
<210> 4075
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4075
Gln Gln Ser Tyr Ser Thr Pro Tyr Thr
1 5
<210> 4076
<211> 10
<212> PRT
<213> Homo sapiens
<400> 4076
Cys Ser Tyr Ala Gly Ser Gly Thr Trp Ile
1 5 10
<210> 4077
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4077
His Gln Tyr Gly Ser Ser Pro Trp Thr
1 5
<210> 4078
<211> 8
<212> PRT
<213> Homo sapiens
<400> 4078
Gln Arg Arg Gly Asp Gly Tyr Asn
1 5
<210> 4079
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4079
Met Gln Ala Thr Asp Trp Pro Arg Thr
1 5
<210> 4080
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4080
Met Gln Thr Thr Asp Trp Pro Arg Thr
1 5
<210> 4081
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4081
Met Gln Gly Thr Glu Trp Pro Arg Thr
1 5
<210> 4082
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4082
Gln Gln Phe Glu Asp Leu Pro Ile Thr
1 5
<210> 4083
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4083
Gln Gln Tyr Tyr Ser Thr Pro Tyr Thr
1 5
<210> 4084
<211> 10
<212> PRT
<213> Homo sapiens
<400> 4084
Gln Gln Tyr Gly Thr Ser Pro Val Tyr Thr
1 5 10
<210> 4085
<211> 11
<212> PRT
<213> Homo sapiens
<400> 4085
Gly Thr Trp Asp Phe Ser Leu Ser Ala Gly Val
1 5 10
<210> 4086
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4086
Met Gln Gly Thr Glu Trp Pro Arg Thr
1 5
<210> 4087
<211> 8
<212> PRT
<213> Homo sapiens
<400> 4087
Gln Gln Tyr Lys Ser Pro Leu Ser
1 5
<210> 4088
<211> 10
<212> PRT
<213> Homo sapiens
<400> 4088
Gln Gln Arg Ser Asp Trp His Pro Ile Thr
1 5 10
<210> 4089
<211> 8
<212> PRT
<213> Homo sapiens
<400> 4089
Gln Gln Ser Tyr Ser Thr Pro Gly
1 5
<210> 4090
<211> 11
<212> PRT
<213> Homo sapiens
<400> 4090
Gln Gln Arg Ala Lys Trp Pro Pro Arg Val Thr
1 5 10
<210> 4091
<211> 11
<212> PRT
<213> Homo sapiens
<400> 4091
Gln Gln Arg Ala Lys Trp Pro Pro Arg Val Ile
1 5 10
<210> 4092
<211> 11
<212> PRT
<213> Homo sapiens
<400> 4092
Tyr Ser Thr Asp Ser Thr Ala Asn Tyr Lys Val
1 5 10
<210> 4093
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4093
Met Gln Gly Thr Glu Trp Pro Arg Thr
1 5
<210> 4094
<211> 12
<212> PRT
<213> Homo sapiens
<400> 4094
Cys Ser Tyr Ala Gly Ser Ser Ala Val Val Val Val
1 5 10
<210> 4095
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4095
Gln Gln Tyr Tyr Ser Thr Pro Tyr Thr
1 5
<210> 4096
<211> 10
<212> PRT
<213> Homo sapiens
<400> 4096
Leu Gln Arg Ser Asp Trp His Pro Ile Thr
1 5 10
<210> 4097
<211> 11
<212> PRT
<213> Homo sapiens
<400> 4097
Gln Gln Arg Ser Asn Trp Pro Pro Arg Leu Thr
1 5 10
<210> 4098
<211> 8
<212> PRT
<213> Homo sapiens
<400> 4098
Leu Gln Tyr Ser Leu Ala Thr Thr
1 5
<210> 4099
<211> 10
<212> PRT
<213> Homo sapiens
<400> 4099
Glu Thr Trp Asp Ser Asn Leu Lys Gly Val
1 5 10
<210> 4100
<211> 10
<212> PRT
<213> Homo sapiens
<400> 4100
Glu Ala Trp Asp Asn Asn Asn Leu Gly Val
1 5 10
<210> 4101
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4101
Leu Gln His Asn Ser Tyr Pro Leu Thr
1 5
<210> 4102
<211> 10
<212> PRT
<213> Homo sapiens
<400> 4102
Met Gln Ala Leu Gln Thr Pro Gly Val Thr
1 5 10
<210> 4103
<211> 11
<212> PRT
<213> Homo sapiens
<400> 4103
Ala Thr Trp Asp Asp Ser Leu Asn Gly Val Val
1 5 10
<210> 4104
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4104
Met Gln Gly Thr Asp Trp Pro Arg Ser
1 5
<210> 4105
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4105
Leu His Thr Tyr Thr Thr Pro Arg Thr
1 5
<210> 4106
<211> 10
<212> PRT
<213> Homo sapiens
<400> 4106
Gln Gln Tyr Asn Tyr Trp Pro Pro Leu Thr
1 5 10
<210> 4107
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4107
Gln Gln Ser Tyr Arg Phe Pro Ile Thr
1 5
<210> 4108
<211> 10
<212> PRT
<213> Homo sapiens
<400> 4108
Gln Gln Arg Thr Asn Trp Pro Gly Ala Thr
1 5 10
<210> 4109
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4109
His Thr Trp Gly Thr Asp Ile Gln Val
1 5
<210> 4110
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4110
Gln Ser Tyr Asp Ser Ser Ser Gln Val
1 5
<210> 4111
<211> 10
<212> PRT
<213> Homo sapiens
<400> 4111
Gln Gln Tyr Asn Tyr Trp Pro Pro Leu Thr
1 5 10
<210> 4112
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4112
Met Gln Gly Thr Glu Trp Pro Arg Thr
1 5
<210> 4113
<211> 8
<212> PRT
<213> Homo sapiens
<400> 4113
Gln Gln Tyr Asn Ser Leu Tyr Thr
1 5
<210> 4114
<211> 10
<212> PRT
<213> Homo sapiens
<400> 4114
Gln Gln Tyr His His Trp Pro Pro Tyr Thr
1 5 10
<210> 4115
<211> 10
<212> PRT
<213> Homo sapiens
<400> 4115
Gln Gln Tyr Cys Ser Thr Pro Pro Tyr Thr
1 5 10
<210> 4116
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4116
Met Gln Gly Thr Glu Trp Pro Arg Thr
1 5
<210> 4117
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4117
Met Gln Gly Thr Asp Trp Pro Arg Ser
1 5
<210> 4118
<211> 10
<212> PRT
<213> Homo sapiens
<400> 4118
Gln Gln Ser Tyr Ser Thr Pro Leu Ile Thr
1 5 10
<210> 4119
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4119
Met Gln Gly Thr Glu Trp Pro Arg Thr
1 5
<210> 4120
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4120
Met Gln Gly Thr Asp Trp Pro Arg Thr
1 5
<210> 4121
<211> 8
<212> PRT
<213> Homo sapiens
<400> 4121
Gln Gln Arg Phe Ser Trp Tyr Asn
1 5
<210> 4122
<211> 11
<212> PRT
<213> Homo sapiens
<400> 4122
Cys Ser Tyr Gly Gly Arg Ser Thr Ser Val Val
1 5 10
<210> 4123
<211> 8
<212> PRT
<213> Homo sapiens
<400> 4123
Gln Gln Arg Phe Ser Trp Tyr Asn
1 5
<210> 4124
<211> 10
<212> PRT
<213> Homo sapiens
<400> 4124
Ser Ser Tyr Thr Ser Gly Gly Thr Leu Val
1 5 10
<210> 4125
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4125
Met Gln Ala Thr Glu Trp Pro Arg Thr
1 5
<210> 4126
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4126
Met Gln Gly Thr Glu Trp Pro Arg Thr
1 5
<210> 4127
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4127
Met Gln Gly Thr Glu Trp Pro Arg Thr
1 5
<210> 4128
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4128
Met Gln Gly Thr Asp Trp Pro Arg Thr
1 5
<210> 4129
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4129
Met Gln Gly Thr Glu Trp Pro Arg Thr
1 5
<210> 4130
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4130
Met Gln Ala Thr Glu Trp Pro Arg Thr
1 5
<210> 4131
<211> 11
<212> PRT
<213> Homo sapiens
<400> 4131
Gln Ser Ala Asp Ser Asn Asp Ser Ser Pro Val
1 5 10
<210> 4132
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4132
His Gln Arg Ser Asn Trp Pro Tyr Thr
1 5
<210> 4133
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4133
Gln Gln Ser Tyr Ser Ile Pro Trp Thr
1 5
<210> 4134
<211> 10
<212> PRT
<213> Homo sapiens
<400> 4134
Gln His Ser Tyr Ser Ser Pro Pro Leu Thr
1 5 10
<210> 4135
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4135
Met Gln Gly Thr Asp Trp Pro Arg Thr
1 5
<210> 4136
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4136
Met Gln Thr Thr Asp Trp Pro Arg Thr
1 5
<210> 4137
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4137
Met Gln Gly Thr Glu Trp Pro Arg Thr
1 5
<210> 4138
<211> 8
<212> PRT
<213> Homo sapiens
<400> 4138
His Gln Tyr Ser Gly Ser Ala Thr
1 5
<210> 4139
<211> 11
<212> PRT
<213> Homo sapiens
<400> 4139
Ala Thr Trp Asp Asp Ile Leu Asn Gly Pro Val
1 5 10
<210> 4140
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4140
Gln Lys Tyr Asn Arg Ala Pro Trp Thr
1 5
<210> 4141
<211> 11
<212> PRT
<213> Homo sapiens
<400> 4141
Ser Ser Tyr Ile Ser Asp Ile Lys Leu Val Val
1 5 10
<210> 4142
<211> 8
<212> PRT
<213> Homo sapiens
<400> 4142
Cys Ser Tyr Ala Gly Thr Tyr Ile
1 5
<210> 4143
<211> 10
<212> PRT
<213> Homo sapiens
<400> 4143
Cys Ser Tyr Arg Ser Asp Asn Thr Tyr Ile
1 5 10
<210> 4144
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4144
Met Gln Gly Thr Glu Trp Pro Arg Thr
1 5
<210> 4145
<211> 13
<212> PRT
<213> Homo sapiens
<400> 4145
Ala Ala Trp Asp Asp Ser Leu Asn Thr Phe Arg Tyr Val
1 5 10
<210> 4146
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4146
Gln Gln Ser Tyr Asn Thr Phe Phe Thr
1 5
<210> 4147
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4147
Gln His Tyr Asp Ser Tyr Pro Thr Ala
1 5
<210> 4148
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4148
Met Gln Gly Thr Glu Trp Leu Gly Thr
1 5
<210> 4149
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4149
Met Gln Gly Thr Glu Trp Pro Arg Thr
1 5
<210> 4150
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4150
Met Gln Thr Thr Asp Trp Pro Arg Thr
1 5
<210> 4151
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4151
Gln Gln Ser Tyr Ser Thr Pro Pro Thr
1 5
<210> 4152
<211> 10
<212> PRT
<213> Homo sapiens
<400> 4152
His Gln Tyr Asn Lys Trp Pro Pro Ile Thr
1 5 10
<210> 4153
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4153
Lys Gln Tyr Asn Ser Tyr Pro Tyr Thr
1 5
<210> 4154
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4154
Gln Gln Ser Tyr Ser Asp Ser Trp Thr
1 5
<210> 4155
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4155
Met Gln Gly Thr Glu Trp Pro Arg Thr
1 5
<210> 4156
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4156
Met Gln Gly Thr Asp Trp Pro Arg Thr
1 5
<210> 4157
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4157
Gln Gln Tyr Tyr Thr Thr Pro Tyr Thr
1 5
<210> 4158
<211> 12
<212> PRT
<213> Homo sapiens
<400> 4158
Gln Gln Thr Tyr Ser Thr Pro Pro Glu Gly Pro Thr
1 5 10
<210> 4159
<211> 11
<212> PRT
<213> Homo sapiens
<400> 4159
Cys Ser Tyr Ala Gly Ala Ser Pro Phe Val Val
1 5 10
<210> 4160
<211> 8
<212> PRT
<213> Homo sapiens
<400> 4160
Gln Gln Tyr Gly Ser Ser Tyr Thr
1 5
<210> 4161
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4161
Met Gln Ala Thr Glu Trp Pro Arg Thr
1 5
<210> 4162
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4162
Met Gln Thr Thr Asp Trp Pro Arg Thr
1 5
<210> 4163
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4163
Met Gln Gly Thr Asp Trp Pro Arg Thr
1 5
<210> 4164
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4164
Met Gln Gly Thr Glu Trp Pro Arg Thr
1 5
<210> 4165
<211> 10
<212> PRT
<213> Homo sapiens
<400> 4165
Cys Ser Tyr Ala Gly Asp Asp Thr Val Val
1 5 10
<210> 4166
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4166
His Gln Tyr Gly Gly Ser Pro Thr Thr
1 5
<210> 4167
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4167
Met Gln Gly Thr Asp Trp Pro Arg Thr
1 5
<210> 4168
<211> 8
<212> PRT
<213> Homo sapiens
<400> 4168
Gln Gln Arg Thr Ser Thr Leu Thr
1 5
<210> 4169
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4169
Met Gln Gly Thr Glu Trp Pro Arg Thr
1 5
<210> 4170
<211> 11
<212> PRT
<213> Homo sapiens
<400> 4170
Glu Thr Trp Asp Ser Ser Leu Ser Val Val Val
1 5 10
<210> 4171
<211> 11
<212> PRT
<213> Homo sapiens
<400> 4171
Gly Thr Trp Asp Ser Arg Leu Ser Ala Val Val
1 5 10
<210> 4172
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4172
Gln Gln Arg Ser Asn Trp Pro Gln Asn
1 5
<210> 4173
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4173
Gln Gln Tyr Asp Ser Tyr Pro Val Thr
1 5
<210> 4174
<211> 8
<212> PRT
<213> Homo sapiens
<400> 4174
Gln Gln Tyr Tyr Thr Met Trp Thr
1 5
<210> 4175
<211> 13
<212> PRT
<213> Homo sapiens
<400> 4175
Gly Thr Trp Asp Ser Ser Leu Ser Val Asp Asn Tyr Val
1 5 10
<210> 4176
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4176
Met Gln Gly Thr Asp Trp Pro Arg Thr
1 5
<210> 4177
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4177
Met Gln Gly Thr Glu Trp Pro Arg Thr
1 5
<210> 4178
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4178
Gln Gln Ser Tyr Ser Thr Pro Leu Thr
1 5
<210> 4179
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4179
Gln Gln Arg Ser Asn Trp Pro Gln Asn
1 5
<210> 4180
<211> 10
<212> PRT
<213> Homo sapiens
<400> 4180
Gln Ser Tyr Asp Ser Ser Leu Ser Ala Ser
1 5 10
<210> 4181
<211> 11
<212> PRT
<213> Homo sapiens
<400> 4181
Gln Ser Tyr Asp Ser Ser Leu Ser Gly Val Leu
1 5 10
<210> 4182
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4182
Met Gln Gly Thr Glu Trp Pro Arg Thr
1 5
<210> 4183
<211> 10
<212> PRT
<213> Homo sapiens
<400> 4183
Gln Gln Tyr Asn Thr Trp Pro Pro Leu Thr
1 5 10
<210> 4184
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4184
Met Gln Gly Thr His Trp Pro Arg Ser
1 5
<210> 4185
<211> 10
<212> PRT
<213> Homo sapiens
<400> 4185
Gln Gln Tyr Gly Ser Ala Pro Leu Tyr Thr
1 5 10
<210> 4186
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4186
Gln Gln Tyr Gly Asn Ser Pro Arg Thr
1 5
<210> 4187
<211> 11
<212> PRT
<213> Homo sapiens
<400> 4187
Glu Thr Trp Asp Thr Ser Leu Ser Val Val Val
1 5 10
<210> 4188
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4188
Met Gln Gly Thr Asp Trp Pro Arg Thr
1 5
<210> 4189
<211> 8
<212> PRT
<213> Homo sapiens
<400> 4189
Leu Gln Tyr Ser Asp Ala Thr Thr
1 5
<210> 4190
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4190
Gln Gln Ser Tyr Thr Thr Pro Ile Thr
1 5
<210> 4191
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4191
Met Gln Ala Thr Glu Trp Pro Arg Thr
1 5
<210> 4192
<211> 11
<212> PRT
<213> Homo sapiens
<400> 4192
Gln Gln Arg Arg Asn Trp Pro Pro Met Tyr Thr
1 5 10
<210> 4193
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4193
Met Gln Thr Thr Asp Trp Pro Arg Thr
1 5
<210> 4194
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4194
Met Gln Thr Thr Asp Trp Pro Arg Thr
1 5
<210> 4195
<211> 10
<212> PRT
<213> Homo sapiens
<400> 4195
Gln Ser Tyr Asp Ser Gly Asn Leu Val Val
1 5 10
<210> 4196
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4196
Met Gln Gly Thr Glu Trp Pro Arg Thr
1 5
<210> 4197
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4197
Met Gln Gly Thr Asp Trp Pro Arg Thr
1 5
<210> 4198
<211> 10
<212> PRT
<213> Homo sapiens
<400> 4198
Gln Gln Tyr Gly Thr Ser Pro Val Tyr Thr
1 5 10
<210> 4199
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4199
Met Gln Gly Thr Asp Trp Pro Arg Thr
1 5
<210> 4200
<211> 11
<212> PRT
<213> Homo sapiens
<400> 4200
Gln Gln Arg Arg Asn Trp Pro Pro Met Tyr Thr
1 5 10
<210> 4201
<211> 12
<212> PRT
<213> Homo sapiens
<400> 4201
Gln Ser Tyr Asp Ser Ser Leu Ser Val Leu Tyr Val
1 5 10
<210> 4202
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4202
Gln His Arg Thr Asn Trp Pro Tyr Thr
1 5
<210> 4203
<211> 10
<212> PRT
<213> Homo sapiens
<400> 4203
Phe Leu Ser Tyr Arg Gly Ala Pro Pro Val
1 5 10
<210> 4204
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4204
Gln Lys His Asp Arg Asp Pro Trp Thr
1 5
<210> 4205
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4205
Met Gln Gly Thr Glu Trp Pro Arg Thr
1 5
<210> 4206
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4206
Gln Gln Ala Glu Ser Phe Pro Phe Thr
1 5
<210> 4207
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4207
Met Gln Ala Thr Asp Trp Pro Arg Thr
1 5
<210> 4208
<211> 8
<212> PRT
<213> Homo sapiens
<400> 4208
Gln Gln Arg Gly Asn Gly Tyr Thr
1 5
<210> 4209
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4209
Met Gln Ala Thr Glu Trp Pro Arg Thr
1 5
<210> 4210
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4210
Met Gln Gly Thr Asp Trp Pro Arg Thr
1 5
<210> 4211
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4211
Met Gln Ala Thr Asp Trp Pro Arg Thr
1 5
<210> 4212
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4212
Gln Gln Ser Tyr Ser Val Pro Leu Thr
1 5
<210> 4213
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4213
Met Gln Ala Thr Asp Trp Pro Arg Thr
1 5
<210> 4214
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4214
Ser Thr Tyr Thr Ser Thr Ser Thr Ile
1 5
<210> 4215
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4215
Met Gln Gly Thr Asp Trp Pro Arg Thr
1 5
<210> 4216
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4216
Met Gln Ala Thr Asp Trp Pro Arg Thr
1 5
<210> 4217
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4217
Gln Gln Thr Tyr Ile Thr Pro Gly Thr
1 5
<210> 4218
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4218
Gln Gln Tyr Tyr Leu Thr Pro Trp Thr
1 5
<210> 4219
<211> 10
<212> PRT
<213> Homo sapiens
<400> 4219
Cys Ser Tyr Ala Val Ser Gly Thr Val Leu
1 5 10
<210> 4220
<211> 8
<212> PRT
<213> Homo sapiens
<400> 4220
Leu Gln Tyr Ser Leu Ala Thr Thr
1 5
<210> 4221
<211> 8
<212> PRT
<213> Homo sapiens
<400> 4221
Gln Gln Arg Ser Asp Gly Tyr Asn
1 5
<210> 4222
<211> 10
<212> PRT
<213> Homo sapiens
<400> 4222
Gln Gln Thr Tyr Ile Thr Pro Thr Trp Thr
1 5 10
<210> 4223
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4223
Gln Gln Ser Tyr Ser Thr Pro Tyr Asn
1 5
<210> 4224
<211> 8
<212> PRT
<213> Homo sapiens
<400> 4224
Gln Gln Tyr Asn Ser Gln Tyr Thr
1 5
<210> 4225
<211> 10
<212> PRT
<213> Homo sapiens
<400> 4225
Cys Ser Ser Pro Gly Thr Ile Thr Trp Val
1 5 10
<210> 4226
<211> 11
<212> PRT
<213> Homo sapiens
<400> 4226
Ala Thr Trp Asp Asp Ile Leu Asn Gly Pro Val
1 5 10
<210> 4227
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4227
Met Gln Ala Thr His Trp Pro Arg Ala
1 5
<210> 4228
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4228
His Gln Tyr Gly Ser Ser Pro Trp Thr
1 5
<210> 4229
<211> 11
<212> PRT
<213> Homo sapiens
<400> 4229
Gln His Arg Ser Asn Trp Pro Pro Arg Tyr Thr
1 5 10
<210> 4230
<211> 11
<212> PRT
<213> Homo sapiens
<400> 4230
Tyr Ser Thr Asp Ser Thr Ala Asn Tyr Lys Val
1 5 10
<210> 4231
<211> 11
<212> PRT
<213> Homo sapiens
<400> 4231
Tyr Ser Thr Asp Ser Thr Ala Asn Tyr Lys Val
1 5 10
<210> 4232
<211> 11
<212> PRT
<213> Homo sapiens
<400> 4232
Tyr Ser Thr Asp Ser Thr Ala Asn Tyr Lys Val
1 5 10
<210> 4233
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4233
Met Ile Trp His Asp Asn Ala Val Val
1 5
<210> 4234
<211> 10
<212> PRT
<213> Homo sapiens
<400> 4234
His Gln Tyr Asn Thr Trp Pro Pro Leu Thr
1 5 10
<210> 4235
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4235
Met Gln Ala Thr His Trp Pro Arg Ala
1 5
<210> 4236
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4236
Met Gln Ser Ile Gln Val Pro Ile Thr
1 5
<210> 4237
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4237
Gln Gln Tyr Asn Leu Trp Pro Tyr Thr
1 5
<210> 4238
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4238
Lys Gln Tyr Asn Ser Tyr Pro Tyr Thr
1 5
<210> 4239
<211> 11
<212> PRT
<213> Homo sapiens
<400> 4239
Glu Thr Trp Asp Asp Ser Leu Ser Ala Val Val
1 5 10
<210> 4240
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4240
Met Gln Ser Ile Gln Thr Pro Ile Thr
1 5
<210> 4241
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4241
Gln Gln Tyr Tyr Ser Thr Pro Pro Thr
1 5
<210> 4242
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4242
Met Gln Ala Thr Glu Trp Pro Arg Thr
1 5
<210> 4243
<211> 10
<212> PRT
<213> Homo sapiens
<400> 4243
Gln Gln Tyr Tyr Thr Thr Pro Leu Phe Thr
1 5 10
<210> 4244
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4244
Met Gln Gly Thr Asp Trp Pro Arg Thr
1 5
<210> 4245
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4245
Met Gln Gly Thr Glu Trp Pro Arg Thr
1 5
<210> 4246
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4246
Met Gln Gly Thr Glu Trp Pro Arg Thr
1 5
<210> 4247
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4247
Met Gln Gly Thr Asp Trp Pro Arg Thr
1 5
<210> 4248
<211> 11
<212> PRT
<213> Homo sapiens
<400> 4248
Ser Ser Tyr Thr Ser Ser Ser Thr Leu Tyr Val
1 5 10
<210> 4249
<211> 8
<212> PRT
<213> Homo sapiens
<400> 4249
Gln Gln Tyr Asn Ser Gly Trp Thr
1 5
<210> 4250
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4250
Met Gln Gly Thr Asp Trp Pro Arg Thr
1 5
<210> 4251
<211> 8
<212> PRT
<213> Homo sapiens
<400> 4251
Leu Gln Leu His Asn Tyr Ser Ser
1 5
<210> 4252
<211> 8
<212> PRT
<213> Homo sapiens
<400> 4252
Gln Gln Arg Ser Asp Gly Tyr Asn
1 5
<210> 4253
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4253
Ser Ser Tyr Thr Ser Thr Asn Thr Val
1 5
<210> 4254
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4254
Met Gln Gly Thr Asp Trp Pro Arg Thr
1 5
<210> 4255
<211> 8
<212> PRT
<213> Homo sapiens
<400> 4255
Cys Ser Ser Pro Gly Thr Ile Thr
1 5
<210> 4256
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4256
Gln Gln Cys Tyr Ser Tyr Pro Pro Thr
1 5
<210> 4257
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4257
Gln Gln Tyr Tyr Ser Thr Pro Tyr Thr
1 5
<210> 4258
<211> 11
<212> PRT
<213> Homo sapiens
<400> 4258
Cys Ser Tyr Thr Arg Thr Asn Thr Pro Val Leu
1 5 10
<210> 4259
<211> 10
<212> PRT
<213> Homo sapiens
<400> 4259
Gln Gln Tyr Tyr Ser Trp Pro Pro Leu Thr
1 5 10
<210> 4260
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4260
Met Gln Gly Thr Asp Trp Pro Arg Thr
1 5
<210> 4261
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4261
Met Gln Ser Thr Asp Trp Pro Arg Thr
1 5
<210> 4262
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4262
Met Gln Gly Thr Glu Trp Pro Arg Thr
1 5
<210> 4263
<211> 10
<212> PRT
<213> Homo sapiens
<400> 4263
Gln Gln Tyr Asn Asn Trp Pro Ser Leu Thr
1 5 10
<210> 4264
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4264
Met Gln Ala Thr Glu Trp Pro Arg Thr
1 5
<210> 4265
<211> 8
<212> PRT
<213> Homo sapiens
<400> 4265
Gln Gln Arg Ser Asp Gly Tyr Asn
1 5
<210> 4266
<211> 11
<212> PRT
<213> Homo sapiens
<400> 4266
Tyr Ser Thr Asp Ser Thr Ala Asn Tyr Lys Val
1 5 10
<210> 4267
<211> 9
<212> PRT
<213> Mus musculus
<400> 4267
Gln Gln Phe Tyr Asn Tyr Pro Arg Thr
1 5
<210> 4268
<211> 7
<212> PRT
<213> Mus musculus
<400> 4268
Gln Gln Asp Tyr Ser Ser Pro
1 5
<210> 4269
<211> 7
<212> PRT
<213> Mus musculus
<400> 4269
Gln Gln Asp Tyr Ser Ser Pro
1 5
<210> 4270
<211> 11
<212> PRT
<213> Mus musculus
<400> 4270
Met Gln His Leu Glu Asn Pro Leu Gly Val Arg
1 5 10
<210> 4271
<211> 7
<212> PRT
<213> Mus musculus
<400> 4271
Leu Gln Tyr His Arg Ser Pro
1 5
<210> 4272
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4272
Gln Gln Ser Tyr Thr Thr Pro Leu Thr
1 5
<210> 4273
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4273
His Gln Thr Tyr Thr Ser Pro Tyr Thr
1 5
<210> 4274
<211> 10
<212> PRT
<213> Homo sapiens
<400> 4274
Gln Gln Tyr Gly Val Ser Pro Glu Ile Ile
1 5 10
<210> 4275
<211> 12
<212> PRT
<213> Homo sapiens
<400> 4275
Gln Val Trp Asp Ser Ser Ser His His His Val Val
1 5 10
<210> 4276
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4276
Gln Gln Ala Asn Ser Phe Pro Leu Thr
1 5
<210> 4277
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4277
Gln Gln Ser Tyr Ser Thr Pro Tyr Thr
1 5
<210> 4278
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4278
Gln Gln Tyr Gly Ser Ser Pro Leu Thr
1 5
<210> 4279
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4279
Gln Gln Phe Gly Ser Ser Pro Leu Thr
1 5
<210> 4280
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4280
Leu Leu Ser Tyr Thr Gly Ala Arg Val
1 5
<210> 4281
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4281
Gln Gln Ala Asn Ser Phe Pro Gly Thr
1 5
<210> 4282
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4282
Gln Gln Ala Asn Ser Phe Pro Gly Thr
1 5
<210> 4283
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4283
Gln Gln Ser Tyr Ser Thr Leu Tyr Ser
1 5
<210> 4284
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4284
Leu Gln His Asn Thr Tyr Pro Phe Thr
1 5
<210> 4285
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4285
His Gln Tyr Gly Ser Ser Pro Trp Thr
1 5
<210> 4286
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4286
Gln Gln Gly Asn Ser Phe Pro Phe Thr
1 5
<210> 4287
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4287
Leu Gln His Asn Thr Tyr Pro Phe Thr
1 5
<210> 4288
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4288
Gln Gln Gly Asn Ser Phe Pro Phe Thr
1 5
<210> 4289
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4289
Leu Gln His Asn Thr Tyr Pro Phe Thr
1 5
<210> 4290
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4290
Gln His Phe Gly Thr Ser Ser Val Thr
1 5
<210> 4291
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4291
Gln Gln Tyr Gly Ser Ser Pro Trp Thr
1 5
<210> 4292
<211> 10
<212> PRT
<213> Homo sapiens
<400> 4292
Ser Ser Tyr Ala Gly Ser Asn Asn Leu Val
1 5 10
<210> 4293
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4293
Met Gln Gly Thr His Trp Pro Pro Thr
1 5
<210> 4294
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4294
Gln Gln Ser Tyr Ser Thr Pro Pro Thr
1 5
<210> 4295
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4295
Gln Gln Tyr Asp Thr Tyr Ser Trp Thr
1 5
<210> 4296
<211> 10
<212> PRT
<213> Homo sapiens
<400> 4296
Gln Gln Ser Tyr Val Ser Pro Thr Tyr Thr
1 5 10
<210> 4297
<211> 11
<212> PRT
<213> Homo sapiens
<400> 4297
Gln Gln Arg Ser Asn Trp Pro Pro Gly Cys Ser
1 5 10
<210> 4298
<211> 8
<212> PRT
<213> Homo sapiens
<400> 4298
Gln Gln His Asp Thr Ser Leu Thr
1 5
<210> 4299
<211> 10
<212> PRT
<213> Homo sapiens
<400> 4299
Cys Ser Tyr Ala Gly Ser Asp Thr Val Ile
1 5 10
<210> 4300
<211> 9
<212> PRT
<213> Homo sapiens
<400> 4300
Gln Ser Ala Asp Ser Ser Gly Thr Val
1 5
Claims (139)
- a) 다가양이온성 구조를 포함하고, 핵산 분자가 없거나 본질적으로 없는 제 1 조성물을 대상체에게 투여하는 단계; 및
b) 제 1 조성물을 투여한 후 상기 대상체에게 적어도 하나의 항-SARS-CoV-2 항체 또는 이의 항원-결합 부분, 및/또는 재조합 ACE2를 암호화하는 다수의 하나 이상의 비-바이러스 발현 벡터를 포함하는 제 2 조성물을 투여하는 단계를 포함하는 방법으로서,
상기 제 1 및 제 2 조성물을 투여한 결과, 상기 적어도 하나의 항-SARS-CoV-2 항체 또는 이의 항원-결합 부분, 및/또는 상기 재조합 ACE2가 상기 대상체에서 발현되는, 방법. - 제 1항에 있어서,
A) 상기 대상체가 SARS-CoV-2 바이러스에 감염되었고, 여기서 상기 적어도 하나의 항-SARS-CoV-2 항체, 또는 이의 항원-결합 부분, 또는 재조합 ACE2는 i) 상기 대상체에서 SARS-CoV-2 바이러스 부하, 및/또는 ii) 상기 SARS-CoV-2 감염에 의해 야기된 상기 대상체의 적어도 하나의 증상을 감소시키기에 충분한 발현 수준으로 상기 대상체에서 발현되거나; 또는
B) 상기 대상체는 SARS-CoV-2 바이러스에 감염되지 않았고, 여기서 상기 적어도 하나의 항-SARS-CoV-2 항체, 또는 이의 항원-결합 부분, 또는 재조합 ACE2는 상기 대상체가 SARS-CoV-2 바이러스에 감염되는 것을 방지하기에 충분한 발현 수준으로 상기 대상체에서 발현되는, 방법. - 제 2항에 있어서, 상기 발현 수준은 i) 단계 a) 및 b)의 임의의 추가 또는 단지 1, 2 또는 3회의 추가 반복, 및 ii) 상기 적어도 하나의 항-SARS-CoV-2 항체 또는 이의 항원-결합 부분, 또는 상기 ACE2를 암호화하는 벡터의 임의의 추가 투여 없이 적어도 2주 동안 상기 대상체에서 유지되는, 방법.
- 제 2항에 있어서, 상기 발현 수준은 i) 단계 a) 및 b)의 임의의 추가 또는 단지 1, 2 또는 3회의 추가 반복, 및 ii) 상기 적어도 하나의 항-SARS-CoV-2 항체 또는 이의 항원-결합 부분, 또는 상기 ACE2를 암호화하는 벡터의 임의의 추가 투여 없이 적어도 1개월 동안 상기 대상체에서 유지되는, 방법.
- 제 2항에 있어서, 상기 발현 수준은 i) 단계 a) 및 b)의 임의의 추가 또는 단지 1, 2 또는 3회의 추가 반복, 및 ii) 상기 적어도 하나의 항-SARS-CoV-2 항체 또는 이의 항원-결합 부분, 또는 상기 ACE2를 암호화하는 벡터의 임의의 추가 투여 없이 적어도 1년 동안 상기 대상체에서 유지되는, 방법.
- 제 1항에 있어서, 상기 적어도 하나의 항-SARS-CoV-2 항체 또는 이의 항원-결합 부분이 i) 적어도 25일 동안 500 ng/ml 내지 50 ug/ml, 또는 10-20 ug/ml, 또는 ii) 적어도 25일 동안 적어도 250 ng/ml의 수준으로 상기 대상체에서 발현되는, 방법.
- 제 1항에 있어서, 상기 다가양이온성 구조가 양이온성 지질을 포함하는, 방법.
- 제 7항에 있어서, 상기 제 1 조성물이 다수의 리포좀을 포함하고, 상기 리포좀의 적어도 일부가 상기 양이온성 지질을 포함하는, 방법.
- 제 7항에 있어서, 상기 리포좀의 적어도 일부는 중성 지질을 포함하는, 방법.
- 제 9항에 있어서, 상기 리포좀에서 상기 양이온성 지질 대 상기 중성 지질의 비율이 95:05-80:20 또는 약 1:1인, 방법.
- 제 10항에 있어서, 상기 양이온성 및 중성 지질이 디스테아로일 포스파티딜 콜린(DSPC); 수소화 또는 비수소화 대두 포스파티딜콜린(HSPC); 디스테아로일포스파티딜에탄올아민(DSPE); 달걀 포스파티딜콜린(EPC); 1,2-디스테아로일-sn-글리세로-3-포스포-rac-글리세롤(DSPG); 디미리스토일 포스파티딜콜린(DMPC); 1,2-디미리스토일-sn-글리세로-3-포스포글리세롤(DMPG); 1,2-디팔미토일-sn-글리세로-3-포스페이트(DPPA); 트리메틸암모늄 프로판 지질; DOTIM(1-[2-9(2)-옥타데세노일옥시)에틸]-2-(8(2)-헵타데세닐)-3-(2-히드록시에틸)미디졸리늄 클로라이드)지질; 및 이들 중 둘 이상의 혼합물로 이루어진 군으로부터 선택되는, 방법.
- 제 1항에 있어서, 상기 하나 이상의 비-바이러스 발현 벡터는 플라스미드를 포함하고, 상기 플라스미드는 임의의 전달제에 부착되거나 캡슐화되지 않는, 방법.
- 제 1항에 있어서, 상기 하나 이상의 비-바이러스 발현 벡터가 항체 경쇄 가변 영역을 암호화하는 제 1 핵산 서열, 및 항체 중쇄 가변 영역을 암호화하는 제 2 핵산 서열, 및 임의로 항체 경쇄 가변 영역을 암호화하는 제 3 핵산 서열, 및 항체 중쇄 가변 영역을 암호화하는 제 4 핵산 서열을 포함하는, 방법.
- 제 1항에 있어서, A) 상기 이의 항원-결합 부분이 Fab', F(ab)2, Fab 및 미니바디로 이루어진 군으로부터 선택되고/되거나, B) 상기 적어도 하나의 항-SARS-CoV-2 항체 또는 이의 항원-결합 부분은 상이한 SARS-CoV-2 항원에 대해 이중-특이적인, 방법.
- 제 1항에 있어서, 상기 항-SARS-CoV-2 항체가 모노클로날 항체 또는 이의 항원-결합 부분이고, REGN10933, REGN10987; VIR-7831; LY-CoV1404; LY3853113; Zost 2355K; CV07-209K; C121L; Zost 2504L; CV38-183L; COVA215K; RBD215; CV07-250L; C144L; COVA118L; C135K; 및 B38로 이루어진 군으로부터 선택되는, 방법.
- 제 1항에 있어서, 상기 항-SARS-CoV-2 항체 또는 이의 항원-결합 부분이 REGN10933, REGN10987; VIR-7831; LY-CoV1404; LY3853113; Zost 2355K; CV07-209K; C121L; Zost 2504L; CV38-183L; COVA215K; RBD215; CV07-250L; C144L; COVA118L; C135K; 및 B38의 적어도 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 또는 초과의 임의의 조합을 포함하는, 방법.
- 제 1항에 있어서, 상기 항-SARS-CoV-2 항체 또는 이의 항원-결합 부분이 표 7에 기재된 바와 같은, 방법.
- 제 1항에 있어서, 상기 적어도 하나의 항-SARS-CoV-2 항체 또는 이의 항원-결합 부분이 적어도 2개의 항-SARS-CoV-2 항체 및/또는 이의 항원-결합 부분을 포함하고, i) 상기 대상체에서 SARS-CoV-2 바이러스 부하, 및/또는 ii) 상기 SARS-CoV-2 감염에 의해 야기된 상기 대상체에서 적어도 하나의 증상을 감소시키기에 충분한 발현 수준으로 상기 대상체에서 발현되는, 방법.
- 제 1항에 있어서, 상기 적어도 하나의 항-SARS-CoV-2 항체 또는 이의 항원-결합 부분이 적어도 4개, 또는 적어도 8개 또는 적어도 11개의 항-SARS-CoV-2 항체 및/또는 이의 항원-결합 부분을 포함하는, 방법.
- 제 1항에 있어서, 상기 적어도 하나의 항-SARS-CoV-2 항체 또는 이의 항원-결합 부분이 적어도 4개, 또는 적어도 8개 또는 적어도 11개의 항-SARS-CoV-2 항체 및/또는 이의 항원-결합 부분을 포함하며, i) 상기 대상체에서 SARS-CoV-2 바이러스 부하, 및/또는 ii) 상기 SARS-CoV-2 감염에 의해 야기된 상기 대상체에서 적어도 하나의 증상을 감소시키기에 충분한 발현 수준으로 상기 대상체에서 발현되는, 방법.
- 제 1항에 있어서, 상기 투여가 정맥내 투여를 포함하는, 방법
- 제 1항에 있어서, 상기 제 2 조성물이 i) 상기 제 1 조성물 후 0.5 내지 80분 사이, 또는 상기 제 1 조성물 후 약 1 내지 20분 사이에 투여되는, 방법.
- 제 1항에 있어서, c) 상기 제 1 및/또는 제 2 조성물에 존재하거나 제 3 조성물에 존재하는 제제를 투여하는 단계를 추가로 포함하고, 여기서 상기 제제는 상기 제제가 상기 대상체에게 투여되지 않은 경우와 비교하여 i) 상기 적어도 하나의 항-SARS-CoV-2 항체 또는 이의 항원-결합 부분의 발현 수준, 및/또는 ii) 상기 발현 시간의 길이를 증가시키는, 방법.
- 제 23항에 있어서, 상기 제제가 상기 제 1 조성물에 존재하는, 방법.
- 제 23항에 있어서, 상기 제제가 상기 제 3 조성물에 존재하고, 상기 제 1 조성물 투여 적어도 1시간 전에 투여되는, 방법.
- 제 23항에 있어서, 상기 제제가 덱사메타손 지방산 에스테르인, 방법.
- 제 26항에 있어서, 상기 덱사메타손 지방산 에스테르가 하기 화학식을 갖는 방법:
여기서, R1은 C5-C23알킬 또는 C5-C23알케닐임. - 제 23항에 있어서, 상기 제제가 0.01-35 mg/ml의 농도로 상기 제 1, 제 2 또는 제 3 조성물에 존재하는, 방법.
- 제 1항에 있어서, 상기 대상체가 폐, 심혈관 및/또는 다기관 염증을 갖는, 방법.
- 제 1항에 있어서, 상기 대상체가 인공호흡기를 착용하고 있는, 방법.
- 제 1항에 있어서, 상기 제 1 및/또는 제 2 조성물이 생리학적으로 허용되는 완충액 또는 정맥내 용액을 추가로 포함하는, 방법.
- 제 1항에 있어서, 상기 제 1 및/또는 제 2 조성물이 락테이트 링거액 또는 식염수를 추가로 포함하는, 방법.
- 제 1항에 있어서, 상기 제 1 조성물이 상기 다가양이온성 구조를 포함하는 리포좀을 포함하고, 상기 리포좀이 만노스 모이어티, 말레이미드 모이어티, 엽산 수용체 리간드, 엽산, 엽산 수용체 항체 또는 이의 단편, 포르밀 펩티드 수용체 리간드, N-포르밀-Met-Leu-Phe, 테트라펩티드 Thr-Lys-Pro-Arg, 갈락토스 및 락토비온산으로 이루어진 군으로부터 선택되는 하나 이상의 대식세포 표적화 모이어티를 추가로 포함하는, 방법.
- 제 1항에 있어서, 상기 다수의 하나 이상의 비-바이러스 발현 벡터가 임의의 전달제에 부착되거나 캡슐화되지 않는, 방법.
- 제 1항에 있어서, 상기 대상체가 인간인, 방법.
- 제 1항에 있어서, 0.05-60 mg/mL의 상기 발현 벡터가 상기 제 2 조성물에 존재하는, 방법.
- 제 1항에 있어서, 상기 다가양이온성 구조는 상기 제 1 조성물에 0.5 내지 100 mM의 농도로 존재하는 양이온성 리포좀을 포함하는, 방법.
- 제 1항에 있어서, 상기 대상체가 인간이고, 여기서:
i) 상기 제 1 조성물의 양은 상기 인간이 상기 다가양이온성 구조의 2-50 mg/kg의 투여량을 받도록 투여되고/되거나
ii) 상기 제 2 조성물의 양은 상기 인간이 상기 발현 벡터의 0.05-60 mg/kg의 투여량을 받도록 투여되는, 방법. - 제 1항에 있어서, 상기 다가양이온성 구조는 양이온성 리포좀을 포함하고, 상기 양이온성 리포좀은 지질 이중층 통합 펩티드 및/또는 표적 펩티드를 추가로 포함하는, 방법.
- 제 39항에 있어서, i) 상기 지질 이중층 통합 펩티드가 계면활성제 단백질 D(SPD), 계면활성제 단백질 C(SPC), 계면활성제 단백질 B(SPB) 및 계면활성제 단백질 A(SPA)로 이루어진 군으로부터 선택되고, ii) 상기 표적 펩티드는 미세소관-연관 서열(MTAS), 핵 국소화 신호(NLS), ER 분비 펩티드, ER 보유 펩티드 및 퍼옥시좀 펩티드로 이루어진 군으로부터 선택되는, 방법.
- 제 1항에 있어서, 단계 a) 및 b)는 초기 단계 b) 후 1 내지 60일 사이에 반복되는, 방법.
- 제 1항에 있어서, 각각의 상기 비-바이러스 발현 벡터는 5,500 내지 30,000개의 핵산 염기쌍을 포함하는, 방법.
- 제 1항에 있어서, 항바이러스제를 상기 대상체에게 투여하는 단계를 추가로 포함하는, 방법.
- 제 43항에 있어서, 상기 항바이러스제는 렘데시비르 또는 ACE2 수용체의 적어도 일부를 포함하는 단백질을 포함하는, 방법.
- 제 1항에 있어서, 항염증제 및/또는 항응고제를 상기 대상체에게 투여하는 단계를 추가로 포함하는, 방법.
- 제 1항에 있어서, 상기 하나 이상의 비-바이러스 발현 벡터가 CPG가 없거나 CPG가 감소된, 방법.
- a) 제 1 용기;
b) 제 1 용기 내부에 있고 다가양이온성 구조를 포함하고, 핵산 분자가 없거나 본질적으로 없는 제 1 조성물;
c) 제 2 용기; 및
d) 제 2 용기 내부에 있고 적어도 하나의 항-SARS-CoV-2 항체 또는 이의 항원-결합 부분, 또는 ACE2 단백질을 암호화하는 다수의 하나 이상의 비-바이러스 발현 벡터를 포함하는 제 2 조성물을 포함하는 시스템. - 제 47항에 있어서, 대상체에게 투여될 때 상기 제제가 상기 대상체에게 투여되지 않을 때와 비교하여 i) 상기 적어도 하나의 항-SARS-CoV-2 항체 또는 이의 항원-결합 부분, 또는 상기 ACE2 단백질의 발현 수준, 및/또는 ii) 상기 발현 시간의 길이를 증가시키는 제제를 추가로 포함하는, 시스템.
- 제 48항에 있어서, 상기 제제가 상기 제 1, 제 2 또는 제 3 조성물에 0.01-35 mg/ml의 농도로 존재하는, 시스템.
- 제 48항에 있어서, 상기 제제가 상기 제 1 조성물 및/또는 상기 제 2 조성물에 존재하는 시스템.
- 제 48항에 있어서, 제 3 용기를 추가로 포함하고, 상기 제제가 상기 제 3 용기에 존재하는, 시스템.
- 대상체에서 적어도 3개의 상이한 항체 또는 이의 항원-결합 부분을 동시에 발현시키는 방법으로서,
a) 다가양이온성 구조를 포함하고, 핵산 분자가 없거나 본질적으로 없는 제 1 조성물을 대상체에게 투여하는 단계; 및
b) 제 1 조성물을 투여한 후 적어도 3개의 상이한 항체 또는 이의 항원-결합 부분을 암호화하는 다수의 하나 이상의 비-바이러스 발현 벡터를 포함하는 제 2 조성물을 상기 대상체에게 투여하는 단계를 포함하며,
여기서 상기 제 1 및 제 2 조성물을 투여한 결과로서, 상기 적어도 3개의 상이한 항체 또는 이의 항원-결합 부분이 상기 대상체에서 동시에 발현되는, 방법. - 제 52항에 있어서, 상기 적어도 3개의 상이한 항체 또는 이의 항원-결합 부분이 적어도 100 ng/ml의 수준으로 상기 대상체에서 각각 발현되는, 방법.
- 제 52항에 있어서, 상기 적어도 3개의 상이한 항체 또는 이의 항원-결합 부분이 적어도 25일 동안 적어도 100 ng/ml의 수준으로 상기 대상체에서 각각 발현되는, 방법.
- 제 52항에 있어서, 상기 적어도 3개의 상이한 항체 또는 이의 항원-결합 부분이 적어도 200 ng/ml의 수준으로 상기 대상체에서 발현되는, 방법.
- 제 52항에 있어서, 상기 적어도 3개의 상이한 항체 또는 이의 항원-결합 부분이 적어도 25일 동안 적어도 200 ng/ml의 수준으로 상기 대상체에서 발현되는, 방법.
- 제 52항에 있어서,
A) 상기 3개의 상이한 항체 또는 이의 항원 결합 부분 각각에 대한 상기 발현 수준이 i) 단계 a) 및 b)의 임의의 추가 또는 단지 1회의 추가 반복, 및 ii) 상기 적어도 3개의 상이한 항체 또는 이의 항원 결합 부분을 암호화하는 벡터의 임의의 추가 투여 없이 적어도 2주 또는 적어도 3주 동안 상기 대상체에서 유지되며,
B) 단계 a) 및 b)를 적어도 1회 또는 적어도 2회 반복하는, 방법. - 제 52항에 있어서, 상기 발현 수준이 i) 단계 a) 및 b의 임의의 추가 또는 단지 1회 또는 2회의 추가 반복, 및 ii) 상기 적어도 3개의 상이한 항체 또는 이의 항원 결합 부분을 암호화하는 벡터의 임의의 추가 투여 없이 적어도 2주 또는 적어도 3주 동안 상기 대상체에서 유지되는, 방법.
- 제 52항에 있어서, 상기 다가양이온성 구조가 양이온성 지질을 포함하는, 방법.
- 제 52항에 있어서, 상기 제 1 조성물이 다수의 리포좀을 포함하고, 상기 리포좀의 적어도 일부가 상기 양이온성 지질을 포함하는, 방법.
- 제 60항에 있어서, 상기 리포좀의 적어도 일부가 중성 지질을 포함하는, 방법.
- 제 60항에 있어서, 상기 리포좀에서 상기 양이온성 지질 대 상기 중성 지질의 비율이 95:05-80:20 또는 약 1:1인, 방법.
- 제 61항에 있어서, 상기 양이온성 및 중성 지질이 디스테아로일 포스파티딜 콜린(DSPC); 수소화 또는 비수소화 대두 포스파티딜콜린(HSPC); 디스테아로일포스파티딜에탄올아민(DSPE); 달걀 포스파티딜콜린(EPC); 1,2-디스테아로일-sn-글리세로-3-포스포-rac-글리세롤(DSPG); 디미리스토일 포스파티딜콜린(DMPC); 1,2-디미리스토일-sn-글리세로-3-포스포글리세롤(DMPG); 1,2-디팔미토일-sn-글리세로-3-포스페이트(DPPA); 트리메틸암모늄 프로판 지질; DOTIM(1-[2-9(2)-옥타데세노일옥시)에틸]-2-(8(2)-헵타데세닐)-3-(2-히드록시에틸)미디졸리늄 클로라이드)지질; 및 이들 중 둘 이상의 혼합물로 이루어진 군으로부터 선택되는, 방법.
- 제 52항에 있어서, 상기 하나 이상의 비-바이러스 발현 벡터가 플라스미드 또는 합성 플라스미드를 포함하고, 상기 플라스미드 및 합성 플라스미드가 임의의 전달제에 부착되거나 캡슐화되지 않는, 방법.
- 제 52항에 있어서, 상기 하나 이상의 비-바이러스 발현 벡터가 3개의 비-바이러스 발현 벡터를 포함하는, 방법.
- 제 65항에 있어서, 각각의 상기 3개의 비-바이러스 발현 벡터가 상이한 항체 또는 이의 항원 결합 단편을 암호화하는, 방법.
- 제 52항에 있어서, 상기 하나 이상의 비-바이러스 발현 벡터가 6개의 비-바이러스 발현 벡터를 포함하는, 방법.
- 제 67항에 있어서, 각각의 상기 6개의 비-바이러스 발현 벡터가 상이한 항체 경쇄 가변 영역, 또는 중쇄 가변 영역을 암호화하는, 방법.
- 제 52항에 있어서, 상기 하나 이상의 비-바이러스 발현 벡터가 각각 항체 경쇄 가변 영역을 암호화하는 제 1, 제 2 및 제 3 핵산 서열, 및 각각 항체 중쇄 가변 영역을 암호화하는 제 4, 제 5 및 제 6 핵산 서열을 포함하는, 방법.
- 제 52항에 있어서, 상기 이의 항원-결합 부분이 Fab', F(ab)2, Fab 및 미니바디로 이루어진 군으로부터 선택되는, 방법.
- 제 52항에 있어서, i) 상기 적어도 3개의 상이한 항체 또는 이의 항원-결합 부분 중 적어도 하나는 항-SARS-CoV-2 항체 또는 이의 항원 결합 부분이거나, 또는 ii) 상기 적어도 3개의 상이한 항체 또는 이의 항원 결합 부분 중 적어도 하나는 SARS-CoV-2에 특이적이고 적어도 하나는 인플루엔자 A에 특이적이고/이거나 적어도 하나는 인플루엔자 B에 특이적인, 방법.
- 제 52항에 있어서, 상기 적어도 3개의 상이한 항체 또는 이의 항- 결합 부분이 REGN10933, REGN10987; VIR-7831; LY-CoV1404; LY3853113; Zost 2355K; CV07-209K; C121L; Zost 2504L; CV38-183L; COVA215K; RBD215; CV07-250L; C144L; COVA118L; C135K; 및 B38의 적어도 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 또는 초과의 임의의 조합을 포함하는, 방법.
- 제 52항에 있어서, 상기 적어도 3개의 상이한 항체 또는 이의 항원-결합 부분이 각각 SARS-CoV-2에 대해 완전히 또는 실질적으로 중화하는, 방법.
- 제 52항에 있어서, 상기 적어도 3개의 상이한 항체 또는 이의 항원-결합 부분이 각각 HIV, 인플루엔자 A, 인플루엔자 B 및 말라리아로 이루어진 군으로부터 선택된 바이러스에 대해 완전히 또는 실질적으로 중화하는, 방법.
- 제 52항에 있어서, 상기 적어도 3개의 상이한 항체 또는 이의 항원-결합 부분 중 적어도 하나는 표 4, 표 5 및/또는 표 7로부터 선택된 항체 또는 이의 항원 결합 부분인, 방법.
- 제 52항에 있어서, 상기 적어도 3개의 상이한 항체 또는 이의 항원-결합 부분이 적어도 4개의 상이한 항체 또는 이의 항원-결합 부분을 포함하는, 방법.
- 제 52항에 있어서, 상기 적어도 3개의 상이한 항체 또는 이의 항원-결합 부분이 적어도 6개의 상이한 항체 또는 이의 항원-결합 부분을 포함하는, 방법.
- 제 52항에 있어서, 상기 적어도 3개의 상이한 항체 또는 이의 항원-결합 부분이 적어도 11개의 상이한 항체 또는 이의 항원-결합 부분을 포함하는, 방법.
- 제 52항에 있어서, 상기 투여가 정맥내 투여를 포함하는, 방법.
- 제 52항에 있어서, 상기 제 2 조성물이 i) 상기 제 1 조성물 후 0.5 내지 80분 사이, 또는 상기 제 1 조성물 후 약 1 내지 20분 사이에 투여되는, 방법.
- 제 52항에 있어서, c) 상기 제 1 및/또는 제 2 조성물에 존재하거나 제 3 조성물에 존재하는 제제를 투여하는 단계를 추가로 포함하고, 여기서 상기 제제는 상기 제제가 상기 대상체에게 투여되지 않은 경우와 비교하여 i) 상기 적어도 3개의 상이한 항체 또는 이의 항원-결합 부분의 발현 수준, 및/또는 ii) 상기 적어도 3개의 상이한 항체 또는 이의 항원-결합 부분의 발현 시간의 길이를 증가시키는, 방법.
- 제 81항에 있어서, 상기 제제가 상기 제 1 조성물에 존재하는, 방법.
- 제 81항에 있어서, 상기 제제가 상기 제 3 조성물에 존재하고, 상기 제 1 조성물 투여 적어도 1시간 전에 투여되는, 방법.
- 제 81항에 있어서, 상기 제제가 덱사메타손 지방산 에스테르인, 방법.
- 제 84항에 있어서, 상기 덱사메타손 지방산 에스테르가 하기 화학식을 갖는 방법:
여기서, R1은 C5-C23알킬 또는 C5-C23알케닐임. - 제 81항에 있어서, 상기 제제가 0.01-35 mg/ml의 농도로 상기 제 1, 제 2 또는 제 3 조성물에 존재하는, 방법.
- 제 52항에 있어서, 상기 제 1 및/또는 제 2 조성물이 생리학적으로 허용되는 완충액 또는 정맥내 용액을 추가로 포함하는, 방법.
- 제 52항에 있어서, 상기 제 1 및/또는 제 2 조성물이 락테이트 링거액 또는 식염수를 추가로 포함하는, 방법.
- 제 52항에 있어서, 상기 제 1 조성물이 상기 다가양이온성 구조를 포함하는 리포좀을 포함하고, 상기 리포좀이 만노스 모이어티, 말레이미드 모이어티, 엽산 수용체 리간드, 엽산, 엽산 수용체 항체 또는 이의 단편, 포르밀 펩티드 수용체 리간드, N-포르밀-Met-Leu-Phe, 테트라펩티드 Thr-Lys-Pro-Arg, 갈락토스 및 락토비온산으로 이루어진 군으로부터 선택되는 하나 이상의 대식세포 표적화 모이어티를 추가로 포함하는, 방법.
- 제 52항에 있어서, 상기 다수의 하나 이상의 비-바이러스 발현 벡터가 임의의 전달제에 부착되거나 캡슐화되지 않는, 방법.
- 제 52항에 있어서, 상기 대상체가 인간인, 방법.
[청구항 91]
제 52항에 있어서, 0.05-60 mg/mL의 상기 발현 벡터가 상기 제 2 조성물에 존재하는, 방법. - 제 52항에 있어서, 상기 다가양이온성 구조는 상기 제 1 조성물에 0.5 내지 100 mM의 농도로 존재하는 양이온성 리포좀을 포함하는, 방법.
- 제 52항에 있어서, 상기 대상체가 인간이고, 여기서:
i) 상기 제 1 조성물의 양은 상기 인간이 상기 다가양이온성 구조의 2-50 mg/kg의 투여량을 받도록 투여되고/되거나
ii) 상기 제 2 조성물의 양은 상기 인간이 상기 발현 벡터의 0.05-60 mg/kg의 투여량을 받도록 투여되는, 방법. - 제 52항에 있어서, 상기 다가양이온성 구조는 양이온성 리포좀을 포함하고, 상기 양이온성 리포좀은 지질 이중층 통합 펩티드 및/또는 표적 펩티드를 추가로 포함하는, 방법.
- 제 94항에 있어서, i) 상기 지질 이중층 통합 펩티드가 계면활성제 단백질 D(SPD), 계면활성제 단백질 C(SPC), 계면활성제 단백질 B(SPB) 및 계면활성제 단백질 A(SPA)로 이루어진 군으로부터 선택되고, ii) 상기 표적 펩티드는 미세소관-연관 서열(MTAS), 핵 국소화 신호(NLS), ER 분비 펩티드, ER 보유 펩티드 및 퍼옥시좀 펩티드로 이루어진 군으로부터 선택되는, 방법.
- 제 52항에 있어서, 단계 a) 및 b)는 초기 단계 b) 후 1 내지 60일 사이에 적어도 1회 반복되는, 방법.
- 제 52항에 있어서, 각각의 상기 비-바이러스 발현 벡터는 5,500 내지 30,000개의 핵산 염기쌍을 포함하는, 방법.
- 제 52항에 있어서, 상기 하나 이상의 비-바이러스 발현 벡터는 CPG가 없거나 CPG가 감소된, 방법.
- a) 제 1 용기;
b) 제 1 용기 내부에 있고 다가양이온성 구조를 포함하고, 핵산 분자가 없거나 본질적으로 없는 제 1 조성물;
c) 제 2 용기; 및
d) 제 2 용기 내부에 있고 적어도 3개의 상이한 항체 또는 이의 항원-결합 부분을 암호화하는 다수의 하나 이상의 비-바이러스 발현 벡터를 포함하는 제 2 조성물을 포함하는, 시스템. - 제 99항에 있어서, 대상체에게 투여될 때 상기 제제가 상기 대상체에게 투여되지 않을 때와 비교하여 i) 상기 적어도 3개의 상이한 항체 또는 이의 항원-결합 부분의 적어도 하나의 발현 수준, 및/또는 ii) 상기 발현 시간의 길이를 증가시키는 제제를 추가로 포함하는, 시스템.
- 제 100항에 있어서, 상기 제제가 상기 제 1, 제 2 또는 제 3 조성물에 0.01-35 mg/ml의 농도로 존재하는, 시스템.
- 제 100항에 있어서, 상기 제제가 상기 제 1 조성물 및/또는 상기 제 2 조성물에 존재하는, 시스템.
- 제 100항에 있어서, 제 3 용기를 추가로 포함하고, 상기 제제가 상기 제 3 용기에 존재하는, 시스템.
- a) 다가양이온성 구조를 포함하고, 핵산 분자가 없거나 본질적으로 없는 제 1 조성물을 대상체에게 투여하는 단계; 및
b) 제 1 조성물을 투여한 후 상기 대상체에게 인간 성장 호르몬(hGH) 및/또는 반감기 연장 펩티드에 연결된 hGH(hGH-ext)를 암호화하는 다수의 비-바이러스 발현 벡터를 포함하는 제 2 조성물을 투여하는 단계
를 포함하는 방법으로서,
여기서, 상기 제 1 및 제 2 조성물을 투여한 결과로서, 상기 hGH가 상기 대상체에서 발현되는, 방법. - 제 104항에 있어서, 상기 hGH 및/또는 hGH-ext는 적어도 1 ng/ml의 혈청 발현 수준으로 상기 대상체에서 발현되는, 방법.
- 제 105항에 있어서, 상기 발현 수준은 i) 단계 a) 및 b)의 임의의 추가 또는 단 1회의 추가 반복, 및 ii) 상기 hGH 또는 hGH-ext를 암호화하는 벡터의 임의의 추가 투여 없이 적어도 2주 동안 상기 대상체에서 유지되는, 방법.
- 제 105항에 있어서, 상기 발현 수준은 i) 단계 a) 및 b)의 임의의 추가 또는 단 1회의 추가 반복, 및 ii) 상기 hGH 또는 hGH-ext를 암호화하는 벡터의 임의의 추가 투여 없이 적어도 1개월 동안 상기 대상체에서 유지되는, 방법.
- 제 105항에 있어서, 상기 발현 수준은 i) 단계 a) 및 b)의 임의의 추가 또는 단 1회의 추가 반복, 및 ii) 상기 hGH 또는 hGH-ext를 암호화하는 벡터의 임의의 추가 투여 없이 적어도 1년 동안 상기 대상체에서 유지되는, 방법.
- 제 104항에 있어서, 상기 다수의 비-바이러스 발현 벡터는 상기 hGH-ext를 암호화하고, 상기 반감기 연장 펩티드는 Fc 영역 펩티드, 혈청 알부민, 인간 융모성 성선자극호르몬 b-서브유닛(CTP)의 카복시 말단 펩티드, 및 XTEN(참조: Schellenberger et al., Nat Biotechnol. 2009 Dec;27(12):1186-90)으로 이루어진 군으로부터 선택되는, 방법.
- 제 104항에 있어서, 상기 다가양이온성 구조가 양이온성 지질을 포함하는, 방법.
- 제 110항에 있어서, 상기 제 1 조성물이 다수의 리포좀을 포함하고, 상기 리포좀의 적어도 일부가 상기 양이온성 지질을 포함하는, 방법.
- 제 110항에 있어서, 상기 리포좀의 적어도 일부가 중성 지질을 포함하는, 방법.
- 제 112항에 있어서, 상기 리포좀에서 상기 양이온성 지질 대 상기 중성 지질의 비율이 95:05-80:20 또는 약 1:1인, 방법.
- 제 112항에 있어서, 상기 양이온성 및 중성 지질이 디스테아로일 포스파티딜 콜린(DSPC); 수소화 또는 비수소화 대두 포스파티딜콜린(HSPC); 디스테아로일포스파티딜에탄올아민(DSPE); 달걀 포스파티딜콜린(EPC); 1,2-디스테아로일-sn-글리세로-3-포스포-rac-글리세롤(DSPG); 디미리스토일 포스파티딜콜린(DMPC); 1,2-디미리스토일-sn-글리세로-3-포스포글리세롤(DMPG); 1,2-디팔미토일-sn-글리세로-3-포스페이트(DPPA); 트리메틸암모늄 프로판 지질; DOTIM(1-[2-9(2)-옥타데세노일옥시)에틸]-2-(8(2)-헵타데세닐)-3-(2-히드록시에틸)미디졸리늄 클로라이드)지질; 및 이들 중 둘 이상의 혼합물로 이루어진 군으로부터 선택되는, 방법.
- 제 104항에 있어서, 상기 발현 벡터는 플라스미드를 포함하고, 상기 플라스미드는 임의의 전달제에 부착되거나 캡슐화되지 않는, 방법.
- 제 104항에 있어서, 상기 투여가 정맥내 투여를 포함하는, 방법.
- 제 104항에 있어서, 상기 제 2 조성물이 i) 상기 제 1 조성물 후 0.5 내지 80분 사이, 또는 상기 제 1 조성물 후 약 1 내지 20분 사이에 투여되는, 방법.
[청구항 116]
제 104항에 있어서, c) 상기 제 1 및/또는 제 2 조성물에 존재하거나 제 3 조성물에 존재하는 제제를 투여하는 단계를 추가로 포함하고, 여기서 상기 제제는 상기 제제가 상기 대상체에게 투여되지 않은 경우와 비교하여 i) 상기 상기 hGH 또는 hGH-ext의 발현 수준, 및/또는 ii) 상기 발현 시간의 길이를 증가시키는, 방법.
[청구항 117]
제 116항에 있어서, 상기 제제가 상기 제 1 조성물에 존재하는, 방법. - 제 116항에 있어서, 상기 제제가 상기 제 3 조성물에 존재하고, 상기 제 1 조성물 투여 적어도 1시간 전에 투여되는, 방법.
- 제 117항에 있어서, 상기 제제가 덱사메타손 지방산 에스테르인, 방법.
- 제 119항에 있어서, 상기 덱사메타손 지방산 에스테르가 하기 화학식을 갖는 방법:
여기서, R1은 C5-C23알킬 또는 C5-C23알케닐임. - 제 116항에 있어서, 상기 제제가 0.01-35 mg/ml의 농도로 상기 제 1, 제 2 또는 제 3 조성물에 존재하는, 방법.
- 제 104항에 있어서, 상기 제 1 및/또는 제 2 조성물이 생리학적으로 허용되는 완충액 또는 정맥내 용액을 추가로 포함하는, 방법.
- 제 104항에 있어서, 상기 제 1 및/또는 제 2 조성물이 락테이트 링거액 또는 식염수를 추가로 포함하는, 방법.
- 제 104항에 있어서, 상기 제 1 조성물이 상기 다가양이온성 구조를 포함하는 리포좀을 포함하고, 상기 리포좀이 만노스 모이어티, 말레이미드 모이어티, 엽산 수용체 리간드, 엽산, 엽산 수용체 항체 또는 이의 단편, 포르밀 펩티드 수용체 리간드, N-포르밀-Met-Leu-Phe, 테트라펩티드 Thr-Lys-Pro-Arg, 갈락토스 및 락토비온산으로 이루어진 군으로부터 선택되는 하나 이상의 대식세포 표적화 모이어티를 추가로 포함하는, 방법.
- 제 104항에 있어서, 상기 다수의 비-바이러스 발현 벡터가 임의의 전달제에 부착되거나 캡슐화되지 않는, 방법.
- 제 104항에 있어서, 상기 대상체가 인간인, 방법.
- 제 104항에 있어서, 0.05-60 mg/mL의 상기 발현 벡터가 상기 제 2 조성물에 존재하는, 방법.
- 제 104항에 있어서, 상기 다가양이온성 구조는 상기 제 1 조성물에 0.5 내지 100 mM의 농도로 존재하는 양이온성 리포좀을 포함하는, 방법.
- 제 104항에 있어서, 상기 대상체가 인간이고, 여기서:
i) 상기 제 1 조성물의 양은 상기 인간이 상기 다가양이온성 구조의 2-50 mg/kg의 투여량을 받도록 투여되고/되거나
ii) 상기 제 2 조성물의 양은 상기 인간이 상기 발현 벡터의 0.05-60 mg/kg의 투여량을 받도록 투여되는, 방법. - 제 104항에 있어서, 상기 다가양이온성 구조는 양이온성 리포좀을 포함하고, 상기 양이온성 리포좀은 지질 이중층 통합 펩티드 및/또는 표적 펩티드를 추가로 포함하는, 방법.
- 제 130항에 있어서, i) 상기 지질 이중층 통합 펩티드는 계면활성제 단백질 D(SPD), 계면활성제 단백질 C(SPC), 계면활성제 단백질 B(SPB) 및 계면활성제 단백질 A(SPA)로 이루어진 군으로부터 선택되고, ii) 상기 표적 펩티드는 미세소관-연관 서열(MTAS), 핵 국소화 신호(NLS), ER 분비 펩티드, ER 보유 펩티드 및 퍼옥시좀 펩티드로 이루어진 군으로부터 선택되는, 방법.
- 제 104항에 있어서, 단계 a) 및 b)는 초기 단계 b) 후 1 내지 60일 사이에 반복되는, 방법.
- 제 104항에 있어서, 각각의 상기 비-바이러스 발현 벡터는 5,500 내지 30,000개의 핵산 염기쌍을 포함하는, 방법.
- 제 104항에 있어서, 상기 비-바이러스 발현 벡터는 CPG가 없거나 CPG가 감소된, 방법.
- a) 다가양이온성 구조를 포함하고, 핵산 분자가 없거나 본질적으로 없는 제 1 조성물을 동물 모델에 투여하는 단계로서,
상기 동물 모델은 SARS-CoV-2에 감염된 단계; 및
b) 제 1 조성물을 투여한 후 제 1 및 제 2 항-SARS-CoV-2 항체 또는 항원- 결합 부분을 암호화하는 다수의 하나 이상의 비-바이러스 발현 벡터를 포함하는 제 2 조성물을 상기 동물 모델에게 투여하는 단계로서;
상기 제 1 및 제 2 조성물을 투여한 결과로서, 상기 제 1 및 제 2 후보 항-SARS-CoV-2 항체 또는 이의 항원-결합 부분이 상기 동물 모델에서 발현되는 단계; 및
c) 상기 제 1 및 제 2 후보 항-SARS-CoV-2 항체 또는 이의 항원-결합 부분의 상기 발현이 i) 상기 동물 모델에서 SARS-CoV-2 바이러스 부하를 감소시키고/시키거나 ii) 상기 동물 모델에서 상기 SARS-CoV-2 감염에 의해 유발된 적어도 하나의 증상을 감소시키는 정도를 결정하는 단계를 포함하는, 방법. - 제 135항에 있어서, 상기 다수의 하나 이상의 비-바이러스 발현 벡터가 제3, 제4, 제5, 제6, 제7, 제8, 제9, 제10 또는 제11 후보 항-SARS-CoV-2 항체 또는 이의 항원-결합 단편을 추가로 암호화하는, 방법.
- 제 135항에 있어서, 상기 동물 모델이 마우스, 래트, 햄스터, 기니 피그, 영장류, 원숭이, 침팬지 또는 토끼로부터 선택되는, 방법.
- 제 135항에 있어서, 상기 제 1 및 항-SARS-CoV2 항체, 또는 이의 항원 결합 부분이 표 7에 있는, 방법.
- 제 135항에 있어서, 상기 제 1 및 제 2 항-SARS-CoV2 항체 또는 이의 항원 결합 부분은 REGN10933, REGN10987; VIR-7831; LY-CoV1404; LY3853113; Zost 2355K; CV07-209K; C121L; Zost 2504L; CV38-183L; COVA215K; RBD215; CV07-250L; C144L; COVA118L; C135K; 및 B38로 이루어진 군으로부터 선택되는, 방법.
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