KR20230085543A - Composition for the prevention of hangover and improving liver functionand Manufacturing method thereof - Google Patents

Composition for the prevention of hangover and improving liver functionand Manufacturing method thereof Download PDF

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KR20230085543A
KR20230085543A KR1020210173801A KR20210173801A KR20230085543A KR 20230085543 A KR20230085543 A KR 20230085543A KR 1020210173801 A KR1020210173801 A KR 1020210173801A KR 20210173801 A KR20210173801 A KR 20210173801A KR 20230085543 A KR20230085543 A KR 20230085543A
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fruit
root
extract
mulberry
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안창균
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안창균
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/02—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation containing fruit or vegetable juices
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00—Function of food ingredients
    • A23V2200/30—Foods, ingredients or supplements having a functional effect on health
    • A23V2200/334—Foods, ingredients or supplements having a functional effect on health treating the effects of consuming alcohol, narcotics or other addictive behavior, e.g. treating hangover or reducing blood alcohol levels
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2250/00—Food ingredients
    • A23V2250/20—Natural extracts
    • A23V2250/21—Plant extracts
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2300/00—Processes
    • A23V2300/14—Extraction

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nutrition Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

본 발명은 산청목, 뽕나무 어린가지, 헛개나무열매, 구기자, 오미자, 참당귀뿌리, 뽕나무열매, 계피, 삽주뿌리, 결명자, 산약, 왕느릅나무껍질, 건생강, 만삼뿌리, 미나리, 곶감을 유효성분으로 포함하는 식물혼합추출물 90~96 중량%, 배농축액 1.5~4.5 중량%, 설탕 1.0~3.5 중량%, 구연산 0.1~1.0 중량%, L-아스파라진 0.1~1.0 중량%, 밀크씨슬 0.05~0.3 중량%, 감귤추출물 0.01~0.05 중량%가 유효성분으로 포함되는 것을 특징으로 하는 숙취해소 및 간기능 개선용 조성물로서, 간에 필요한 영양소의 공급, 혈액순환 개선, 만성피로 개선 등을 통해 간기능 개선 및 숙취해소 효과가 있다.The present invention is active ingredients of sancheongmok, mulberry young branches, hovenia tree fruit, goji berry, Schisandra chinensis, angelica root, mulberry fruit, cinnamon, shovel root, gyeolmyeongja, sanyak, king elm bark, dried ginger, mansam root, water parsley, dried persimmon 90-96% by weight of plant mixture extract, 1.5-4.5% by weight of pear concentrate, 1.0-3.5% by weight of sugar, 0.1-1.0% by weight of citric acid, 0.1-1.0% by weight of L-asparagine, 0.05-0.3% by weight of milk thistle A composition for relieving hangover and improving liver function, characterized in that it contains 0.01 to 0.05% by weight of tangerine extract as an active ingredient, improving liver function and It has a hangover cure effect.

Description

숙취해소 및 간기능 개선용 조성물 및 그 제조방법{Composition for the prevention of hangover and improving liver functionand Manufacturing method thereof}Composition for the prevention of hangover and improving liver function and manufacturing method thereof}

본 발명은 숙취해소 및 간기능 개선용 기능성 조성물 관한 것으로, 식물혼합추출물에 배농축액, 설탕, 구연산, L-아스파라진, 밀크씨슬, 감귤추출물을 성분으로 포함하는 숙취해소 및 간기능 개선에 치료 효과가 있는 기능성 조성물 및 그 제조방법에 관한 것이다. The present invention relates to a functional composition for relieving hangover and improving liver function, comprising a plant mixture extract containing pear concentrate, sugar, citric acid, L-asparagine, milk thistle, and citrus extract as components for relieving hangover and improving liver function. It relates to a functional composition with an effect and a manufacturing method thereof.

간은 우리 몸에서 지질 등의 대사 작용, 해독, 담즙의 배설, 각종 영양소의 저장, 조혈이나 혈액 응고 및 순환 혈액량의 조절 등 많은 기능을 갖는 매우 중요한 장기이다.The liver is a very important organ that has many functions in our body, such as metabolism of lipids, detoxification, excretion of bile, storage of various nutrients, hematopoiesis, blood coagulation, and control of circulating blood volume.

이와 같은 간은, 특히 약물, 술, 독성물질 등을 해독시키는 해독 및 분해기능도 갖고 있어 간세포가 손상되기 쉽고 이에 따라 약물성, 독성, 알코올성 간 질환 등이 흔히 발생하게 된다. Such a liver also has detoxification and decomposition functions to detoxify drugs, alcohol, toxic substances, etc., and thus liver cells are easily damaged, so drug-induced, toxic, and alcoholic liver diseases often occur.

특히, 회식과 접대가 잦고 스트레스가 많은 현대인들에게 음주는 필수적인 것으로 자리잡고 있으며, 과다한 음주는 일시적으로 두근거림, 두통, 갈증, 멀미, 위장장애, 설사 등의 숙취현상(hangover)을 유발한다.In particular, drinking is essential for modern people who have frequent dinners and entertainment and have a lot of stress. Excessive drinking temporarily causes hangovers such as palpitations, headaches, thirst, motion sickness, gastrointestinal disorders, and diarrhea.

이와 같은 간장 장해에 대하여 임상적으로 효과가 인정되는 약물 및 간장 장해에 대한 유효한 천연 약물탐색은 많은 연구자에 의해 이루어지고 있는 실정으로, 현재 간염, 간경화의 예방 및 치료를 위해 가장 일반적으로 사용되는 약제는 우르소데옥시콜린산, 면역자극제, 항바이러스제, 실리마린, 운지다당체, 메티오닌 등이 있으나 아직까지 임상적으로 만족스러운 효과를 제공하는 약제가 없어 새로운 간질환 치료제가 강하게 요구되는 실정이다.Many researchers are currently searching for drugs whose effectiveness is clinically recognized for liver disorders and effective natural drugs for liver disorders, and are currently the most commonly used drugs for the prevention and treatment of hepatitis and liver cirrhosis. There are ursodeoxycholic acid, immunostimulant, antiviral agent, silymarin, fingering polysaccharide, methionine, etc., but there is no drug that provides clinically satisfactory effects yet, so a new liver disease treatment is strongly required.

또한, 기존의 간 질환 치료에 사용되는 약제들의 단점을 보완하기 위한 대체체로 생약성분 및 이들의 추출물을 이용하고자 하는 시도가 많이 이루어지고 있다.In addition, many attempts have been made to use herbal ingredients and extracts thereof as substitutes for supplementing the disadvantages of existing drugs used for liver disease treatment.

대한민국 공개특허 제1992-0019344호에는, 아마씨나 들깨에 함유되어 있는 α- 리놀렌산을 이용한 간장 질환 예방 및 치료조성물이 공개되어 있고, 대한민국 공개특허 제2000-0061327호에는, 황기, 오미자, 감초 등의 생약조성물을 이용한 간 질환 예방 및 치료용 생약 조성물이 공개되어 있으며, 대한민국 공개특허 제1998-0048620호에는 황기유래의 이소플라본을 함유하는 간기능 개선제가 공개되어 있고, 대한민국 공개특허 제2003-0019591호에는 간기능 개선 및 간 질환 치료를 위한 기능성 식품 조성물 및 이의 제조방법, 대한민국 공개특허 제2005-0078080호에는 숙취해소 및 알콜성 간손상 회복에 유효한 간기능 개선 손바닥 선인장 식물추출물 등이 공개되어 있다.Korean Patent Publication No. 1992-0019344 discloses a composition for preventing and treating liver diseases using α-linolenic acid contained in flaxseed or perilla seeds, and Korean Patent Publication No. 2000-0061327 discloses a composition for astragalus, Schisandra chinensis, licorice, etc. A herbal composition for preventing and treating liver diseases using a herbal composition is disclosed, and Korean Patent Publication No. 1998-0048620 discloses a liver function improving agent containing isoflavone derived from Astragalus, and Korean Patent Publication No. 2003-0019591 discloses a functional food composition for improving liver function and treating liver disease and a method for preparing the same, and Korean Patent Publication No. 2005-0078080 discloses a palm cactus plant extract for improving liver function effective for relieving hangover and recovering from alcoholic liver damage.

또한, 에탄올의 독성을 경감시키거나 독성의 발현을 저해할 수 있는 많은 물질에 대한 연구와 실험이 지속적으로 진행되어 왔고, 이와 관련된 천연식품이나 한약재료로부터 추출한 성분을 함유한 다양한 건강보조식품이 개발되고 있는 실정이다.In addition, studies and experiments on many substances that can reduce the toxicity of ethanol or inhibit the expression of toxicity have been continuously conducted, and various health supplements containing ingredients extracted from natural foods or herbal medicine materials related to this have been developed. It is becoming.

이에 맞추어 인삼, 가시오가피 등의 성분을 주성분으로 하는 각종 제제 형태의 기능성 식품들이 개발되었고, 그 중 인삼을 주성분으로 하는 자양강장 드링크제가 다수 시판되고, 콩나물을 주원료한 식물 엑기스를 함유한 제품과 미배아와 대두 추출물을 함유한 제품이 소개되고 있으나, 음주에 의해 유발되는 다양한 숙취증상 중에서 일부 증상에만 효과가 있거나 숙취해소 효과가 미미하고, 제제의 안전성 면에서 문제점이 지적되었다.In line with this, functional foods in the form of various preparations with ingredients such as ginseng and ginseng as the main ingredient have been developed, and among them, many nutritious drinks with ginseng as the main ingredient are commercially available, products containing plant extracts made from bean sprouts as the main ingredient, and rice embryos Although products containing soybean extracts and soybean extracts have been introduced, they are only effective on some symptoms among various hangover symptoms caused by drinking, or the hangover relief effect is insignificant, and problems have been pointed out in terms of safety of the preparation.

한편 본 발명과 관련된 선행기술로서 대한민국 공개특허 제2002-0029036호에 헛개나무와 오가피를 혼합하여 증숙과정을 거친 후, 이들에 배, 밤, 곶감, 대추 및 정수를 첨가 혼합하여 가열농축 여과하여 헛개나무 추출물을 주성분으로 함유하는 음료의 제조방법에 관한 내용이 있다.On the other hand, as a prior art related to the present invention, Korean Patent Publication No. 2002-0029036 mixes barnacles and cucumbers and goes through a steaming process, then adds pears, chestnuts, dried persimmons, jujubes and purified water to them, heats and concentrates, and filtrate There is information on a method for producing a beverage containing a tree extract as a main component.

대한민국 공개특허 제2004-0052261호에 헛개나무추출액에 비타민 C를 강화한 숙취제거용 음료의 제조방법에 관한 것으로, 헛개나무 추출액을 단독으로 함유하고 있는 음료보다 숙취 회복의 효과가 월등히 향상되는 비타민 Ｃ 강화 헛개나무 추출액 함유 음료의 제조방법에 관한 내용이 있다.Korean Patent Publication No. 2004-0052261 relates to a method for manufacturing a beverage for relieving hangovers in which vitamin C is fortified in extracts of raisin raisin. There is a method for manufacturing a beverage containing barnacle extract.

이와같은, 음주 후의 숙취제거를 위하여 각종 생약제를 포함하는 드링크제는 전신권태, 복부팽만감, 구토 또는 복통 등을 유발하는 경우가 있을 뿐 아니라, 일부 드링크제는 고가의 생약제를 사용함으로써 고가로 판매되는 등의 문제점이 있다.Drinks containing various herbal medicines to remove hangovers after drinking may cause general malaise, abdominal distension, vomiting or abdominal pain, and some drinks are sold at high prices by using expensive herbal medicines. There is a problem.

이에 본 발명자는 연구를 거듭한 결과, 인체에 부작용이 없으면서 숙취해소 및 간기능 개선 효능을 가진 본 발명의 기능성 조성물을 개발하였다.Accordingly, as a result of repeated research, the present inventors have developed a functional composition of the present invention having effects of relieving hangover and improving liver function without side effects on the human body.

대한민국 공개특허 제1992-0019344호Republic of Korea Patent Publication No. 1992-0019344 대한민국 공개특허 제2000-0061327호Republic of Korea Patent Publication No. 2000-0061327 대한민국 공개특허 제1998-0048620호Republic of Korea Patent Publication No. 1998-0048620 대한민국 공개특허 제2003-0019591호Republic of Korea Patent Publication No. 2003-0019591 대한민국 공개특허 제2005-0078080호Republic of Korea Patent Publication No. 2005-0078080 대한민국 공개특허 제2002-0029036호Republic of Korea Patent Publication No. 2002-0029036 대한민국 공개특허 제2004-0052261호Republic of Korea Patent Publication No. 2004-0052261

본 발명의 목적은 선별된 식물혼합추출물에 배농축액, 설탕, 구연산, L-아스파라진, 밀크씨슬, 감귤추출물을 성분으로 포함시켜 숙취해소 및 간기능 개선에 치료 효과가 있는 기능성 조성물을 제공함에 있다. An object of the present invention is to provide a functional composition having a therapeutic effect on relieving hangover and improving liver function by including pear concentrate, sugar, citric acid, L-asparagine, milk thistle, and citrus extract in the selected plant mixture extract as components. there is.

상기 목적을 달성하기 위하여, In order to achieve the above purpose,

본 발명의 일 실시예에 따른 숙취해소 및 간기능 개선용 조성물은,The composition for relieving hangover and improving liver function according to an embodiment of the present invention,

식물혼합추출물 90~96 중량%, 배농축액 1.5~4.5 중량%, 설탕 1.0~3.5 중량%, 구연산 0.1~1.0 중량%, L-아스파라진 0.1~1.0 중량%, 밀크씨슬 0.05~0.3 중량%, 감귤추출물 0.01~0.05 중량%가 유효성분으로 포함되는 것을 특징으로 한다.90-96% by weight of plant mixture extract, 1.5-4.5% by weight of pear concentrate, 1.0-3.5% by weight of sugar, 0.1-1.0% by weight of citric acid, 0.1-1.0% by weight of L-asparagine, 0.05-0.3% by weight of milk thistle, It is characterized in that 0.01 to 0.05% by weight of citrus extract is included as an active ingredient.

또한, 본 발명에 따른 숙취해소 및 간기능 개선용 조성물은,In addition, the composition for relieving hangover and improving liver function according to the present invention,

상기 식물혼합추출물은 산청목, 뽕나무 어린가지, 헛개나무열매, 구기자, 오미자, 참당귀뿌리, 뽕나무열매, 계피, 삽주뿌리, 결명자, 산약, 왕느릅나무껍질, 건생강, 만삼뿌리, 미나리, 곶감을 유효성분으로 포함되는 것을 특징으로 한다.The plant mixture extract is Sancheongmok, mulberry young branches, barberry fruit, goji berry, Schisandra chinensis, angelica root, mulberry fruit, cinnamon, shovel root, gyeolmyeongja, mountain medicine, king elm bark, dried ginger, mansam root, water parsley, dried persimmon Characterized in that it is included as an active ingredient.

또한, 본 발명에 따른 숙취해소 및 간기능 개선용 조성물은,In addition, the composition for relieving hangover and improving liver function according to the present invention,

상기 식물혼합추출물은, 상기 식물혼합추출물 100중량% 기준으로 산청목 1~2 중량%, 뽕나무 어린가지 1~2 중량%, 헛개나무열매 2~5 중량%, 구기자나무열매 3~4 중량%, 오미자열매 1~2 중량%, 참당귀뿌리 0.1~2 중량%, 뽕나무열매 0.1~1 중량%, 계피 0.1~1 중량%, 삽주뿌리 0.1~1.5 중량%, 결명자 0.1~1.0 중량%, 산약 1~2 중량%, 왕느릅나무껍질 0.1~1.0 중량%, 건생강 0.1~1.0 중량%, 만삼뿌리 0.1~1.0 중량%, 미나리 0.1~1.0 중량%, 곶감 2~3 중량% 및 정제수 57.5~88 중량%로 이루어지는 것을 특징으로 한다.The plant mixture extract is, based on 100% by weight of the plant mixture extract, 1 to 2% by weight of Sancheongmok, 1 to 2% by weight of mulberry young branches, 2 to 5% by weight of Hovenia tree fruit, 3 to 4% by weight of Goji japonica fruit, Schisandra chinensis Fruit 1-2% by weight, Angelica gigas root 0.1-2% by weight, Mulberry fruit 0.1-1% by weight, Cinnamon 0.1-1% by weight, Shovel root 0.1-1.5% by weight, Cassia tora 0.1-1.0% by weight, Acid medicine 1-2 % by weight, king elm bark 0.1-1.0% by weight, dried ginger 0.1-1.0% by weight, mansam root 0.1-1.0% by weight, water parsley 0.1-1.0% by weight, dried persimmon 2-3% by weight and purified water 57.5-88% by weight characterized by being made.

또한, 본 발명에 따른 숙취해소 및 간기능 개선용 조성물은,In addition, the composition for relieving hangover and improving liver function according to the present invention,

상기 식물혼합추출물은, 상기 식물혼합추출물 100중량% 기준으로 산청목 1.67 중량%, 뽕나무 어린가지 1.58 중량%, 헛개나무열매 2.53 중량%, 구기자나무열매 3.13 중량%, 오미자열매 1.56 중량%, 참당귀뿌리 0.78 중량%, 뽕나무열매 0.83 중량%, 계피 0.73 중량%, 삽주뿌리 0.73 중량%, 결명자 0.78 중량%, 산약 1.19 중량%, 왕느릅나무껍질 0.63 중량%, 건생강 0.47 중량%, 만삼뿌리 0.31 중량%, 미나리 0.46 중량%, 곶감 2.07 중량% 및 정제수 80.55 중량%로 이루어지는 것을 특징으로 한다.The plant mixture extract, based on 100% by weight of the plant mixture extract, 1.67% by weight of Sancheongmok, 1.58% by weight of mulberry young branches, 2.53% by weight of Hovenia japonica fruit, 3.13% by weight of Goji japonica fruit, 1.56% by weight of Schisandra chinensis fruit, 0.78% by weight, 0.83% by weight of mulberry fruit, 0.73% by weight of cinnamon, 0.73% by weight of shovel root, 0.78% by weight of Cassia tora, 1.19% by weight of acid medicine, 0.63% by weight of king elm bark, 0.47% by weight of dry ginger, 0.31% by weight of mansam root , characterized in that it consists of 0.46% by weight of water parsley, 2.07% by weight of dried persimmon, and 80.55% by weight of purified water.

또한, 본 발명에 따른 숙취해소 및 간기능 개선용 조성물은,In addition, the composition for relieving hangover and improving liver function according to the present invention,

식물혼합추출물 100중량% 기준으로, 산청목 1.67 중량%, 뽕나무 어린가지 1.58 중량%, 헛개나무열매 2.53 중량%, 구기자나무열매 3.13 중량%, 오미자열매 1.56 중량%, 참당귀뿌리 0.78 중량%, 뽕나무열매 0.83 중량%, 계피 0.73 중량%, 삽주뿌리 0.73 중량%, 결명자 0.78 중량%, 산약 1.19 중량%, 왕느릅나무껍질 0.63 중량%, 건생강 0.47 중량%, 만삼뿌리 0.31 중량%, 미나리 0.46 중량%, 곶감 2.07 중량% 및 정제수 80.55 중량%로 이루어진 식물혼합추출물 94.37 중량%;Based on 100% by weight of plant mixture extract, 1.67% by weight of Sancheongmok, 1.58% by weight of young branches of mulberry, 2.53% by weight of Hovenia fruit, 3.13% by weight of Goji japonica fruit, 1.56% by weight of Schisandra chinensis fruit, 0.78% by weight of Angelica root, mulberry fruit 0.83% by weight, cinnamon 0.73% by weight, shovel root 0.73% by weight, Cassia tora 0.78% by weight, acid medicine 1.19% by weight, king elm bark 0.63% by weight, dried ginger 0.47% by weight, mansam root 0.31% by weight, parsley 0.46% by weight, 94.37% by weight of a plant mixture extract consisting of 2.07% by weight of dried persimmon and 80.55% by weight of purified water;

배농축액 2.67 중량%;2.67% by weight of pear concentrate;

갈색설탕 2.5 중량%;2.5% by weight of brown sugar;

구연산 0.17 중량%;0.17% by weight of citric acid;

L-아스파라진 0.17 중량%; 0.17% by weight of L-asparagine;

밀크씨슬 0.1 중량%; 및0.1% by weight of milk thistle; and

감귤추출물 0.02 중량%;를 유효성분으로 포함하는 것을 특징으로 한다.Citrus extract 0.02% by weight; characterized in that it contains as an active ingredient.

또한, 본 발명에 따른 숙취해소 및 간기능 개선용 조성물 제조방법은,In addition, the method for preparing a composition for relieving hangover and improving liver function according to the present invention,

산청목, 뽕나무 어린가지, 헛개나무열매, 구기자, 오미자, 참당귀뿌리, 뽕나무열매, 계피, 삽주뿌리줄기, 결명자, 산약, 왕느릅나무껍질, 건생강, 만삼뿌리, 미나리, 곶감을 각각 건조 후 마쇄하여 분말화 한 후, 각 분말을 산청목 1.67 중량%, 뽕나무 어린가지 1.58 중량%, 헛개나무열매 2.53 중량%, 구기자 3.13 중량%, 오미자 1.56 중량%, 참당귀뿌리 0.78 중량%, 뽕나무열매 0.83 중량%, 계피 0.73 중량%, 삽주뿌리줄기 0.73 중량%, 결명자 0.78 중량%, 산약 1.19 중량%, 왕느릅나무껍질 0.63 중량%, 건생강 0.47 중량%, 만삼뿌리 0.31 중량%, 미나리 0.46 중량%, 곶감 2.07 중량% 계측하여 혼합하는 단계;Sancheongmok, mulberry young branch, hovenia tree fruit, goji berry, Schisandra chinensis, angelica root, mulberry fruit, cinnamon, shovel rhizome, gyeolseongja, sanyak, king elm bark, dried ginger, mansam root, water parsley, dried persimmon are dried and ground After powdering, each powder was 1.67% by weight of Sancheongmok, 1.58% by weight of mulberry young branches, 2.53% by weight of Hovenia fruit, 3.13% by weight of goji berry, 1.56% by weight of Schisandra chinensis, 0.78% by weight of Angelica root, 0.83% by weight of mulberry fruit , Cinnamon 0.73% by weight, shovel rhizome 0.73% by weight, Cassia tora 0.78% by weight, acid medicine 1.19% by weight, king elm bark 0.63% by weight, dried ginger 0.47% by weight, mansam root 0.31% by weight, parsley 0.46% by weight, dried persimmon 2.07 Mixing by measuring weight %;

상기 혼합한 혼합분말에 3~5배의 물을 첨가한 후 100~110℃의 추출온도에서 1시간 ~ 3시간 동안 열수 추출하고 고형물을 제거한 다음 감압농축하여 식물혼합추출물을 수득하는 단계;Obtaining a mixed plant extract by adding 3 to 5 times of water to the mixed powder, performing hot water extraction at an extraction temperature of 100 to 110 ° C. for 1 hour to 3 hours, removing solids, and then concentrating under reduced pressure;

배를 아황산나트륨 수용액에 10~30 분간 침지한 다음, 침지 처리된 배를 착즙하여 수득된 주스를 100 ℃의 온도에서 10~30분간 가열농축하여 배농축액을 제조하는 단계;Preparing a pear concentrate by immersing pears in an aqueous solution of sodium sulfite for 10 to 30 minutes and then heating and concentrating the juice obtained by squeezing the soaked pears at a temperature of 100 ° C. for 10 to 30 minutes;

감귤류 진피를 준비하여 세척 및 건조한 후 분쇄하고 중탕 가열한 후 냉각시키고, 재차 가열한 후 여과 과정을 통해 고형물을 제거하여 액상의 감귤추출물을 수득하는 단계; 및Preparing citrus dermis, washing, drying, pulverizing, heating in a water bath, cooling, heating again, and removing solids through filtration to obtain a liquid citrus extract; and

상기 수득한 식물혼합추출물 94.37 중량%와 배농축액 2.67 중량%, 감귤추출물 0.02 중량%에, 설탕 2.5 중량%, 구연산 0.17 중량%, L-아스파라진 0.17 중량%, 밀크씨슬 0.1 중량%을 가한 후, 100~110℃ 온도에서 30분~1시간 열탕가열하여 숙취해소 및 간기능 개선용 혼합추출물을 제조하는 단계;를 포함하여 구성되는 것을 특징으로 한다.94.37% by weight of the plant mixture extract obtained above, 2.67% by weight of pear concentrate, and 0.02% by weight of citrus extract, 2.5% by weight of sugar, 0.17% by weight of citric acid, 0.17% by weight of L-asparagine, and 0.1% by weight of milk thistle were added. , preparing a mixed extract for relieving hangover and improving liver function by heating in hot water at a temperature of 100 to 110 ° C. for 30 minutes to 1 hour.

본 발명에 따라 제조된 기능성 조성물은 임상실험 결과 우수한 숙취해소 및 간기능 개선 효능을 나타냈다.The functional composition prepared according to the present invention showed excellent effects on relieving hangover and improving liver function as a result of clinical trials.

또한, 본 발명의 조성물을 유효성분으로 함유하는 기능성 식품은 독성 및 부작용이 없는 식품 및 생약성분을 배합하여 편리하게 섭취하게 함으로써 간에 필요한 영양소의 공급, 혈액순환 개선, 만성피로 개선 등을 통해 간기능 개선에 효과적인 기능성 식품 조성물을 제공할 수 있다.In addition, the functional food containing the composition of the present invention as an active ingredient is conveniently ingested by combining food and herbal ingredients without toxicity and side effects, thereby improving liver function by supplying nutrients necessary for the liver, improving blood circulation, and improving chronic fatigue. A functional food composition effective for improvement can be provided.

이하, 본 발명의 내용을 실시예 및 비교예를 통하여 보다 구체적으로 설명한다. 이들 실시예 및 비교예는 본 발명의 내용을 이해하기 위해 제시되는 것일 뿐 본 발명의 권리범위가 이들 실시예 및 비교예로 한정되는 것은 아니다.Hereinafter, the contents of the present invention will be described in more detail through Examples and Comparative Examples. These Examples and Comparative Examples are only presented to understand the contents of the present invention, but the scope of the present invention is not limited to these Examples and Comparative Examples.

본 발명에 따른 숙취해소 및 간기능 개선용 조성물은, 식물혼합추출물, 배농축액, 설탕, 구연산, L-아스파라진, 밀크씨슬, 감귤추출물을 성분으로 포함하는 것으로서, 식물혼합추출물은 90~96 중량%, 배농축액 1.5~4.5 중량%, 설탕 1.0~3.5 중량%, 구연산 0.1~1.0 중량%, L-아스파라진 0.1~1.0 중량%, 밀크씨슬 0.05~0.3 중량%, 감귤추출물 0.01~0.05 중량%, 바람직하게는 식물혼합추출물 93~95 중량%, 배농축액 2.0~3.5 중량%, 설탕 2.0~3.0 중량%, 구연산 0.1~0.2 중량%, L-아스파라진 0.1~0.2 중량%, 밀크씨슬 0.08~0.2 중량%, 감귤추출물 0.01~0.03 중량%, 가장 바람직하게는 식물혼합추출물 94.37 중량%, 배농축액 2.67 중량%, 설탕 2.5 중량%, 구연산 0.17 중량%, L-아스파라진 0.17 중량%, 밀크씨슬 0.1 중량%, 감귤추출물 0.02 중량%를 함유하는 것이 특징이다. The composition for relieving hangover and improving liver function according to the present invention includes a mixed plant extract, pear concentrate, sugar, citric acid, L-asparagine, milk thistle, and a citrus extract as components, and the mixed plant extract contains 90 to 96 % by weight, pear concentrate 1.5-4.5% by weight, sugar 1.0-3.5% by weight, citric acid 0.1-1.0% by weight, L-asparagine 0.1-1.0% by weight, milk thistle 0.05-0.3% by weight, citrus extract 0.01-0.05% by weight %, preferably 93-95% by weight of plant mixture extract, 2.0-3.5% by weight of pear concentrate, 2.0-3.0% by weight of sugar, 0.1-0.2% by weight of citric acid, 0.1-0.2% by weight of L-asparagine, 0.08% by weight of milk thistle ~0.2% by weight, 0.01~0.03% by weight of citrus extract, most preferably 94.37% by weight of plant mixture extract, 2.67% by weight of pear concentrate, 2.5% by weight of sugar, 0.17% by weight of citric acid, 0.17% by weight of L-asparagine, milk seed It is characterized by containing 0.1% by weight of seul and 0.02% by weight of citrus extract.

본 발명에 따른 숙취해소 및 간기능 개선용 조성물에서 식물혼합추출물은 90~96 중량% 사용될 수 있다. 식물혼합추출물이 90 중량% 미만이면 간기능 개선효과 및 알콜과 아세트알데하이드의 대사에 관련된 효소(Aldehyde Dehydrogenase)의 활성 강화효과가 미흡하고, 96 중량%를 초과하면 그에 따른 효과의 증가가 나타나지 않는다.In the composition for relieving hangover and improving liver function according to the present invention, 90 to 96% by weight of the mixed plant extract may be used. If the plant mixture extract is less than 90% by weight, the effect of improving liver function and enhancing the activity of the enzyme (Aldehyde Dehydrogenase) related to the metabolism of alcohol and acetaldehyde is insufficient, and if it exceeds 96% by weight, the corresponding increase in effect does not appear.

또한, 본 발명에 따른 숙취해소 및 간기능 개선용 조성물에서 배농축액은 1.5~4.5 중량% 사용될 수 있다. 배농축액이 1.5 중량% 미만이면 면역력 증진 및 산성중화효과가 미흡하고 4.5 중량% 초과하면 그에 따른 효과의 증가가 나타나지 않는다.In addition, in the composition for relieving hangover and improving liver function according to the present invention, 1.5 to 4.5% by weight of the pear concentrate may be used. If the pear concentrate is less than 1.5% by weight, the immunity enhancement and acid neutralization effect is insufficient, and if it exceeds 4.5% by weight, the corresponding increase in effect does not appear.

또한, 본 발명에 따른 숙취해소 및 간기능 개선용 조성물에서 설탕은 갈색설탕 1.0~3.5 중량%가 사용될 수 있다. 갈색설탕이 1.0중량% 미만이면 각 구성성분의 충돌을 방지하는 완충작용을 못하고 쓴맛을 개선시키지 못하며, 3.5 중량%를 초과하게 되면 지나친 단맛으로 인해 풍미를 잃게하고 초과량에 따른 효과증가가 없다.In addition, in the composition for relieving hangover and improving liver function according to the present invention, 1.0 to 3.5% by weight of brown sugar may be used as sugar. If the brown sugar is less than 1.0% by weight, it does not have a buffering action to prevent collision of each component and does not improve the bitter taste, and if it exceeds 3.5% by weight, the flavor is lost due to excessive sweetness and the effect does not increase according to the excess amount.

또한, 본 발명에 따른 숙취해소 및 간기능 개선용 조성물에서 구연산은 0.1~1.0 중량% 사용될 수 있다. 구연산 함량이 0.1 중량% 미만이면 혈액 산성화 개선효능이 없고, 1.0 중량%를 초과하면 다른 구성성분과의 상승작용도 없고 약알카리성 유지기능도 없다.In addition, in the composition for relieving hangover and improving liver function according to the present invention, 0.1 to 1.0% by weight of citric acid may be used. If the citric acid content is less than 0.1% by weight, there is no blood acidification improving effect, and if it exceeds 1.0% by weight, there is no synergistic effect with other components and no function to maintain weak alkalinity.

또한, 본 발명에 따른 숙취해소 및 간기능 개선용 조성물에서 L-아스파라진은 0.1~1.0 중량% 사용될 수 있다. L-아스파라진 함량이 0.1 중량% 미만이면 간기능 개선효능이 없고, 1.0 중량%를 초과하면 그에 따른 효과의 증가가 나타나지 않는다.In addition, in the composition for relieving hangover and improving liver function according to the present invention, 0.1 to 1.0% by weight of L-asparagine may be used. If the L-asparagine content is less than 0.1% by weight, there is no liver function improving effect, and if it exceeds 1.0% by weight, the effect does not increase accordingly.

또한, 본 발명에 따른 숙취해소 및 간기능 개선용 조성물에서 밀크씨슬은 0.05~0.3 중량% 사용될 수 있다. 밀크씨슬 함량이 0.05 중량% 미만이면 독소로부터 간세포를 보호하고 해독하는 효능이 없고, 0.3 중량%를 초과하면 그에 따른 효과의 증가가 나타나지 않는다.In addition, in the composition for relieving hangover and improving liver function according to the present invention, 0.05 to 0.3% by weight of milk thistle may be used. If the milk thistle content is less than 0.05% by weight, there is no effect of protecting and detoxifying liver cells from toxins, and if it exceeds 0.3% by weight, the effect does not increase accordingly.

또한, 본 발명에 따른 숙취해소 및 간기능 개선용 조성물에서 감귤추출물은 0.01~0.05 중량% 사용될 수 있다. 감귤추출물 함량이 0.01 중량% 미만이면 비타민C나 구연산이 부족하여 물질대사 촉진기능이 없을 뿐만아니라 카로티노이드 성분 중 감귤류에 많이 들어 있는 베타크립토산틴의 항산화·항암 등의 활성 효능이 없고, 0.05 중량%를 초과하면 그에 따른 효과의 증가가 나타나지 않는다.In addition, in the composition for relieving hangover and improving liver function according to the present invention, 0.01 to 0.05% by weight of citrus extract may be used. If the content of citrus extract is less than 0.01% by weight, there is no metabolism promoting function due to lack of vitamin C or citric acid. Exceeding this will not increase the effect.

여기서, 식물혼합추출물은 조성물이 산청목, 뽕나무 어린가지, 헛개나무열매, 구기자, 오미자, 참당귀뿌리, 뽕나무열매, 계피, 삽주뿌리, 결명자, 산약, 왕느릅나무껍질, 건생강, 만삼뿌리, 미나리, 곶감을 포함하여 구성된다.Here, the plant mixture extract is composed of sancheongmok, mulberry young branches, barberry fruit, wolfberry, Schisandra chinensis, angelica root, mulberry fruit, cinnamon, shovel root, Cassia tora, sanyak, king elm bark, dried ginger, mansam root, water parsley , It is composed of dried persimmons.

산청목은, 벌나무(Acer tegmentosum maxim)라고도 불리며, 단풍나무과의 낙엽활엽교목으로 고지대에서 습생하는 식물로 우리나라에서는 전통적으로 산청목 껍질을 약재로 사용해 왔으며 간기능 회복, 지사제 등의 효능과, 독성이 없어 어떤 체질에도 부작용이 없다고 알려져 있다.Sancheongmok, also called bee tree (Acer tegmentosum maxim), is a deciduous broad-leaved arboretum of the Maple family and grows in highlands. In Korea, the bark of Sancheongmok has traditionally been used as a medicine. It is known that there are no side effects on the constitution.

산초는 동북 아시아권에서 동북 아시아권에서 널리 자생하고 있는 운향과(Rutaceae)의 낙엽관목으로서 분지나무 또는 상초나무로도 불리며, limonene, citronellal 등의 향기 주요성분과, flavonoid계 성분, caproic acid 등의 지방산 화합물의 성분을 포함한다. 산초의 약효로는 온중, 산한, 제습, 지통, 살충의 효능이 있고, 소화불량, 위내정수, 심복냉통, 구토, 하리, 음부소양증을 치료한다고 알려져 있다.Sancho is a deciduous shrub of the Rutaceae family that grows wild in Northeast Asia and Northeast Asia, and is also called a branch tree or an herbaceous tree. contains the components of Sancho's medicinal properties include warmth, acid cold, dehumidification, pain relief, and insecticidal effects, and it is known to treat indigestion, intragastric water, cold heart pain, vomiting, hari, and genital pruritis.

뽕나무는, 칼슘 등의 각종 미네랄이 50여종이 포함되어 있어 비만증, 각기병과 몸이 붓는 증세, 풍, 멍들고 아픈증세, 청뱅(눈 뜬장님), 머리가 자라지 않는 증세, 탈항, 종기, 동창, 당뇨병치료와 혈압 및 혈당강하, 항암, 노화방지 등에 효과가 있는 것으로 알려져 있고, 이는 녹차에 비해서 칼슘은 6.1배, 철분은 2.2배, 칼리는 1.4배에 해당된다고 한다.The mulberry tree contains about 50 kinds of various minerals such as calcium, so it can be used to treat obesity, beriberi, body swelling, wind, bruising and pain, blue-eyed blindness, hair loss, prolapse, boils, alumni, and diabetes. It is known to be effective in treatment, lowering blood pressure and blood sugar, anti-cancer, anti-aging, etc., and compared to green tea, calcium is 6.1 times, iron is 2.2 times, and potassium is 1.4 times.

특히, 뽕나무 어린가지는 술독을 제거하는 아스파라긴산과 알라닌, 뇌속의 피를 잘 돌게 하고 콜레스테롤을 제거하면 노인성 치매를 예방해 주는 세린과 타이로신, 혈압 강화작용이 있어 뇌출혈, 방사선 장해, 각종 출혈성 질환을 예방해 주는 루틴(Rutin), 혈압 강하 작용을 하는 아미노 부티르산 이외에도 탄닌(Tannin), 유산과당, 프락토스(Fructos), 스타시오스(Stacyose), 포도당, 말토스(Maltose), 라피노스(Raffinose), 아라비노스(Arabinos), 자일로스(Xylos), 베타-아미린(β-Amyrin), 알파-헥사놀(α-Hexanol), 크리산세민(Chrysanthemin), 쿠드라린(Cudrarin), 이소퀘르시트린(Isoquercitrin), 모린(Morin), 플라보노이드계등의 성분이 포함되어 있어 폐암, 대장암, 피부암, 자궁암, 간질환, 고혈압 및 뇌졸중 등에 효과가 있는 것으로 알려져 있다.In particular, mulberry young branches contain aspartic acid and alanine, which remove alcohol poison, serine and tyrosine, which improve blood circulation in the brain and prevent senile dementia by removing cholesterol, and rutin, which strengthens blood pressure and prevents cerebral hemorrhage, radiation damage, and various hemorrhagic diseases. In addition to Rutin and amino butyric acid, which lower blood pressure, tannin, fructose, fructose, stacyose, glucose, maltose, raffinose, arabinos ), Xylos, β-Amyrin, α-Hexanol, Chrysanthemin, Cudrarin, Isoquercitrin, Morin ( Morin), flavonoids, etc. are included, and are known to be effective for lung cancer, colon cancer, skin cancer, uterine cancer, liver disease, high blood pressure and stroke.

헛개나무열매(oriental raisin tree fruit)는 갈매나무과의 낙엽활엽교목인 헛개나무의 열매로, 헛개나무는 높이 10m 정도이고 수피는 검은빛을 띤 회색으로 세로로 갈라지고 벗겨진다. 잎은 어긋나고 넓은 달걀모양 또는 타원모양으로 가장자리에 잔거치가 있다. 잎의 앞면은 녹색으로 털이 없고 뒷면은 연한 녹색으로 맥위에 털이 없거나 있다. 열매는 9~10월에 익으며 둥근모양이고 갈색을 띤다.The oriental raisin tree fruit is the fruit of the raisin tree, a deciduous broad-leaved arboretum of the buckthorn family. Leaves are alternate, wide egg-shaped or oval, with fine rough edges. The front side of the leaf is green and hairless, and the back side is light green with no hairs on the veins. The fruit ripens in September-October and is round and brown.

헛개나무열매는 열매가 익을 무렵에 과경이 굵어져서 울퉁불퉁하게 된다. 은은한 향기가 있고, 단맛이 있어 먹을 수 있으며 음식맛을 한결 돋운다. 또한"본초강목"에 술을 썩히는 작용이 있다고 하며 생즙은 술독을 풀고 구역질을 멎게 한다고 기재되어 있으며, 최근에는 숙취에 대한 효과가 있음이 알려져 숙취 해소 음료의 재료로도 사용되고 있다.When the fruit is ripe, the barn tree fruit becomes thick and bumpy. It has a subtle fragrance and a sweet taste, so it can be eaten and enhances the taste of food. In addition, it is said that "herb herb" has the effect of rotting alcohol, and the juice is said to relieve alcohol poisoning and stop nausea.

구기자는 가지과(Solanaceae)에 속한 구기자나무 Lycium chinense Mill. 또는 기타 동속식물의 성숙한 과실로, Carotene 3.39㎎％, vitamin B1 0.23㎎％, vitamin B2 0.33㎎％, nicotin acid 1.7㎎％, vitamin C 3㎎％을 함유하고, β-sitosterol, linoleic acid등이 함유되어 있다.Goji is Lycium chinense Mill belonging to Solanaceae. Or other mature fruits of plants of the same genus, containing 3.39 mg% of carotene, 0.23 mg% of vitamin B1, 0.33 mg% of vitamin B2, 1.7 mg% of nicotin acid, and 3 mg% of vitamin C, and contains β-sitosterol and linoleic acid. has been

오미자는, 오미자과(Schisandraceae)에 속한 오미자(북오미자) Schisandra chinensis Baill. 또는 화중오미자(남오미자) S. sphenanthera Rehd. et Wils.의 완숙한 과실을 건조한 것으로, 정유가 약 3％가 함유되어 있으며, 정유 속에 다양의 sesquicarene, β2 -bisabclene, β-chamigrene, α-ylangene 등이 함유되어 있다. 건조된 오미자열매는 citral 12％, 사과산 10％ 및 소량의 주석산을 함유하고 그 밖에 과당, 수지 등이 함유되어 있다. 갈증을 해소하고 간을 회복시킨다.Schisandra chinensis Baill, belonging to Schisandraceae. or Schisandra chinensis (Schisandra chinensis) S. sphenanthera Rehd. et Wils., contains about 3% of essential oil, and various sesquicarene, β2-bisabclene, β-chamigrene, and α-ylangene are contained in the essential oil. Dried Schizandra fruit contains citral 12%, malic acid 10% and a small amount of tartaric acid, and fructose and resin are also contained. It quenches thirst and restores the liver.

참당귀뿌리는, 참당귀(Angelica gigas NAKAI)의 뿌리를 지칭하는 것으로, 참당귀는 비교적 습한 땅에 나는 두해살이 또는 세해살이풀이다. 상기 참당귀의 살찐 뿌리에는 젖빛 즙을 함유하고 있으며 강한 향을 풍긴다.The root of Angelica gigas refers to the root of Angelica gigas NAKAI, which is a biennial or perennial plant that grows in relatively moist soil. The fat root of Angelica gigas contains milky juice and exudes a strong fragrance.

뽕나무열매(이하 "오디")는, 동의보감에는 "까만 오디는 뽕나무의 정령이 모여있는 것이며, 당뇨와 오장에 이롭다. 오래 먹으면 허기침을 잊는다"고 기록되고 있고, 또한 화한약백과도감에 오디가 "간장과 신장을 보익하고 음혈(정력)을 길러 주는 효능이 있고 양혈거풍의 작용을 한다"라고 기록되어 있으며, 현재에도 그것의 여러 생리활성으로 인하여 쨈, 젤리, 쥬스, 시럽, 술 등의 식품의 재료로 이용되거나 화장품 등의 재료로도 다양하게 이용되고 있다.Mulberry fruit (hereinafter referred to as "mulberry") is recorded in Donguibogam as "black mulberry is the gathering of the spirits of the mulberry tree, and is beneficial to diabetes and the five intestines. Eating it for a long time makes you forget hunger." It is recorded that it "has the effect of nourishing the liver and kidneys and nurturing yin blood (energy), and acts as a yang blood exorcism." It is used as a material for cosmetics or variously used as a material for cosmetics.

계피는, 녹나무과(Lauraceae)에 속한 육계 Cinnamomum cassia Presl의 수피로 정유성분이 1～2％ 함유되어 있는데, 그 주성분은 cinnamaldehyde가 75～90％이다. 성질은 뜨겁고 맛은 맥고 달다.Cinnamon is the bark of the broiler Cinnamomum cassia Presl belonging to the Lauraceae family and contains 1 to 2% of essential oil, the main component of which is 75 to 90% of cinnamaldehyde. The nature is hot and the taste is malty and sweet.

삽주뿌리(창출)는 삽주(학명: Atractylodes ovata)의 뿌리를 껍질을 벗기지 않고 0.5-1.0cm의 두께로 썰어 햇볕에 말린 것을 말한다. 창출(삽주뿌리)는 장(腸)의 연동운동을 촉진하여 소화의 촉진과 가스의 배출을 돕고 부종을 제거하는 효능이 있다.Shovel roots (changchul) refers to the sun-dried roots of shovel (scientific name: Atractylodes ovata) without peeling them and cutting them into 0.5-1.0cm thick. Creation (sapju root) promotes peristaltic movement of the intestines, promotes digestion, helps discharge gas, and has the effect of removing edema.

결명자는, 결명자는 콩과의 일년생 초본식물 결명초의 종자를 말하는 것으로서, 비타민 C, 에모딘(Emodin), 베타카로틴, 안트라퀴논(Anrhraquinone) 유도체를 포함하고 있다. 이러한 결명자는 눈, 안과질병에 효과가 있고, 이뇨작용과 배변작용을 용이하게 하며, 간을 다스려 해독작용에도 탁월한 것으로 알려져 있다.Cassia tora refers to the seeds of Cassia tora, an annual herbaceous plant belonging to the legume family, and contains vitamin C, Emodin, beta-carotene, and Anrhraquinone derivatives. These defects are known to be effective for eye and eye diseases, facilitate diuretic and bowel movements, and are excellent for detoxification by controlling the liver.

산약은, 마과(Dioscoreaceae)에 속한 마 Dioscorea batatas Decne.(＝D. opposita Thunb.)와 참마 D.japonica Thunb.의 껍질을 제거한 뿌리줄기로 사포닌(Saponin), 점액, 콜린(cholin), 전분(16％), 글리코프로틴(glycoprotein)과 유리아미노산을 함유하며, 또한 abscisin Ⅱ, polyphenol 산화효소, 비타민 C, 3,4-dihydroxy-phenyle-thylamine(dopamine)을 함유하고 점액 중에는 마난(mannan)과 피틴(phytin)산이 함유되어 있다.Sanyak is the peeled rhizome of Dioscorea batatas Decne. (= D. opposita Thunb.) and D. japonica Thunb. belonging to the Dioscoreaceae family, and contains saponin, mucilage, choline, and starch ( 16%), glycoprotein and free amino acids, and also contains abscisin II, polyphenol oxidase, vitamin C, 3,4-dihydroxy-phenyle-thylamine (dopamine), and mannan and phytin in mucus. (phytin) acid is contained.

왕느릅나무껍질은, 버드나무과(Salicaceae)의 낙엽교목인 버드나무의 뿌리껍질(Ulmus macrocarpa Hance)로, 검은 갈색이고 얕게 갈라지며 작은 가지는 노란빛을 띤 녹색으로 밑으로 처지고 털이 나지만 없어진다. 약물의 성미는 고신(苦辛), 한(寒)하고, 간, 신, 방광경에 작용하는데, 청열하고 습을 제거하며 풍을 헤치고 부스럼을 삭이는 효능이 있어 방광염, 황달형, 안염, 풍습성관절염, 소변불리, 습진, 치통이뇨, 해열제, 이뇨제, 폐농양, 구내염, 치은염 치료제로 쓰여 왔다.The bark of king elm is the root bark (Ulmus macrocarpa Hance) of the willow tree, a deciduous tree of the Salicaceae family. The nature of the drug is high in pain, cold, and acts on the liver, kidneys, and bladder. It has the effect of clearing heat, removing dampness, clearing wind, and removing boils, so it is effective in cystitis, jaundice, blepharitis, and customary arthritis. It has been used as a treatment for urinary incontinence, eczema, toothache, diuretic, antipyretic, diuretic, lung abscess, stomatitis, and gingivitis.

화학 성분은 살리실산(salicylic acid), 튜틴(tutin), 나린게닌-7-글루코시드(naringenin-7-glucoside), 나린게닌-5-글루코시드(naringenin-5-glucoside), 쿠에르시트린(quercitrin), 쿠에르세트린(quercetrin) 등을 함유하고 있는 것으로 알려져 있으나, 약리작용으로는 중추억제작용 및 강압작용의 보고가 있으며(Balbaa S. I. et al., U.S. Dispensatory, 25Ed, p98, 1983 ; 녹회흥 et al., 중초약, 15(12), p540,1984), 면역 증강 효과도 있다.Chemical components: salicylic acid, tutin, naringenin-7-glucoside, naringenin-5-glucoside, quercitrin , quercetrin, etc., but there are reports of central depressant action and hypotensive action as pharmacological action (Balbaa S. I. et al., U.S. Dispensatory, 25Ed, p98, 1983; Nokhoeheung et al. al., Chinese herbal medicine, 15(12), p540,1984), also has an immune enhancing effect.

건생강은 생강을 건조한 것으로, 생강은 항응혈작용, 건위작용, 식욕증진작용, 신진대사기능촉진작용, 구토억제작용, 소염진통작용, 혈액점도낮춤작용, 설사, 차멀미 예방, 풍습통, 코막힘, 오한, 가래, 수종, 땀내기(발한), 해열, 구토, 위가 차고 배가 아픈 데, 기침, 방향성 건위약, 백반증, 신진대사기능을 촉진한다.Ginger is dried ginger. Ginger has anticoagulant action, gastric action, appetite enhancing action, metabolic function promoting action, vomiting suppression action, anti-inflammatory analgesic action, blood viscosity lowering action, diarrhea, car sickness prevention, customs pain, nasal congestion. , chills, phlegm, dropsy, sweating (perspiration), antipyretic, vomiting, cold stomach, stomach pain, cough, aromatic weakness, vitiligo, promotes metabolism.

만삼뿌리는, 도라지과의 여러해살이 풀인 "만삼(蔓蔘)"의 뿌리를 일컫으며, 학명은 Codonopsis pilosula (Franch.) Nannf. 또는 Codonopsis tangshen Oliv. 이다. 또한, 만삼은 당삼 또는 천당삼이라고도 불린다. 중국에서는 코도높시스 필로술라(C. pilosula (Franch.) Nannf.) 및 코도높시스 탕셈 (C. tangshem Oliv)의 뿌리를 건조한 것을 만삼이라고 하지 않고 당삼이라고 하며, 전자를 서당, 후자를 천당이라고 한다.Mansam root refers to the root of "Mansam", a perennial plant of the bellflower family, whose scientific name is Codonopsis pilosula (Franch.) Nannf. or Codonopsis tangshen Oliv. am. Mansam is also called Dangsam or Cheondangsam. In China, dried roots of C. pilosula (Franch.) Nannf. and C. tangshem Oliv are called Dangsam, not Mansam. it's called heaven

만삼은 대한민국의 강원도, 경상남도에서 자생 한다. 만삼은 적혈구를 증가시키고 백혈구를 감소시키며, 면역력증강, 강장작용, 위산과다로 인한 소화성궤양등의 치료제로 민간에서 사용되어 왔다. 또한, 만삼은 인삼의 부작용이 있는 사람에게 인삼대용으로 사용되어온 약재이다 (박종희, 이정규, 상용 약용 식물도감, p115, 도서출판 신일상사(2000)).Mansam grows wild in Gangwon-do and Gyeongsangnam-do in Korea. Mansam increases red blood cells and reduces white blood cells, and has been used in the private sector as a remedy for immunity enhancement, tonic action, and peptic ulcer caused by excessive stomach acid. In addition, mansam is a medicinal material that has been used as a substitute for ginseng for people with side effects of ginseng (Park Jong-hee and Lee Jeong-gyu, Encyclopedia of Common Medicinal Plants, p115, Shinilsangsa (2000)).

미나리(Oenanthe stolonifera)는 쌍떡잎식물 산형화목 미나리과의 여러해살이풀로 우리 나라 전역에 자생하며, 사할린섬, 중국대륙, 일본, 동남아시아, 오세아니아 등 아한대, 온대로부터 열대까지 널리 분포되어 있다. Water parsley (Oenanthe stolonifera) is a perennial plant of the dicotyledonous plant umbel Apiaceae, which grows wild throughout Korea and is widely distributed from subarctic, temperate to tropical regions such as Sakhalin Island, mainland China, Japan, Southeast Asia, and Oceania.

미나리는 비타민 A, B1, B2, C 등이 다량 함유하고 있고, 단백질, 철분, 칼슘, 인 등 무기질이 풍부한 알칼리성 식품으로, 쌀을 주식으로 하는 우리 나라 사람들에게 일어날 수 있는 혈액의 산성화를 막아주며, 특유의 정유성분(이소람네틴, 페르시카린, 알파피넨, 미르센 등)과 철분이 함유하고 있어 정신을 맑게 하고 혈액을 보호하는 효과가 있고 심한 갈증을 없애고 열을 깨끗이 내리게 하는 효과도 있다. 또한 미나리는 해독 및 중금속 정화작용이 있고 가래를 삭히며 기관지와 폐를 보호하는 효능도 있으며, 변비에 효험이 있는 것으로 알려져 있다. 또한 미나리는 알코올의 분해를 빠르게 하여 숙취제거에 효과가 있다. 또한 미나리는 수분이 맣기 때문에 변통 촉진성 식품이라 볼 수 있으며, 미나리의 생즙이 황달이나 소장질환, 대장질환, 신경쇠약등에 좋은 치유효과를 나타내는 것으로 알려져 있다. Water parsley contains a large amount of vitamins A, B1, B2, and C, and is an alkaline food rich in minerals such as protein, iron, calcium, and phosphorus. , It contains unique essential oil components (isoramnetin, persicarin, alpha-pinene, myrcene, etc.) and iron, so it has the effect of clearing the mind and protecting blood, eliminating severe thirst and clearing fever. In addition, water parsley has detoxification and heavy metal purification, clears phlegm, protects the bronchi and lungs, and is known to be effective for constipation. Water parsley is also effective in removing hangovers by speeding up the decomposition of alcohol. In addition, water parsley can be regarded as a food that promotes bowel movements because of its high water content, and water parsley's juice is known to have a good healing effect on jaundice, small intestine disease, colon disease, and nervous breakdown.

곶감은 비타민A와 비타민C(사과의10배)가 풍부한 건강보조식품으로서, 끝 맛이 떫은 타닌 성분이 설사를 멎게 해주고 모세혈관을 강화시켜서 고혈압을 사전에 예방할 수 있다. 또한, 음주 전후에 복용하면 숙취해소에 탁월한 효과가 있고, 만성기관지염 등의 치료에 쓰이며, 곶감을 꾸준히 먹게 되면 면역력이 향상되어서 각종 질병 및 감기예방에 효과적이다.Dried persimmon is a health supplement rich in vitamin A and vitamin C (10 times that of an apple), and its tannin component, which has an astringent taste at the end, stops diarrhea and strengthens capillaries to prevent high blood pressure in advance. In addition, when taken before and after drinking, it has an excellent effect on relieving a hangover, and is used in the treatment of chronic bronchitis, etc., and when dried persimmons are consumed steadily, immunity is improved and is effective in preventing various diseases and colds.

본 발명인 숙취해소용 조성물에서 창출(삽주뿌리), 감귤추출물은 복합적으로 상승작용하여 소화기의 부종을 없애고 소화기의 연동운동을 강화시켜 에탄올의 소화기 체류시간을 줄이고, 요관의 연동운동을 강화하여 에탄올의 신속한 체외배출을 이룰 수 있다. 에탄올의 소화기 체류시간을 줄이고 신속히 체외로 배출시킴으로써 숙취발생을 사전적으로 예방할 수 있다.In the composition for relieving hangover according to the present invention, Changjo (scapular root) and citrus extract have a complex synergistic effect to eliminate edema in the digestive tract and strengthen the peristaltic movement of the digestive tract to reduce the retention time of ethanol in the digestive tract and to strengthen the peristaltic movement of the ureters to reduce the amount of ethanol. Rapid excretion can be achieved. Hangover can be prevented in advance by reducing the residence time of ethanol in the digestive system and quickly excreting it out of the body.

또한, 본 발명인 숙취해소용 조성물에서 헛개나무줄기, 오미자열매가 복합적으로 상승작용하여 간의 기능을 개선하고, 알콜과 아세트알데하이드의 대사에 관련된 효소(Aldehyde Dehydrogenase)의 활성을 증가시켜 해독작용을 촉진시키고, 간에서 소화기로의 독소물질의 배출을 증진시키고 요관의 움직임을 좋게하여 각종 독소를 체외로 배출시킴으로써, 숙취의 발생을 억제할 수 있다.In addition, in the composition for relieving hangover of the present invention, hovenia tree stem and Schizandra chinensis complexly act synergistically to improve liver function, increase the activity of enzymes related to alcohol and acetaldehyde metabolism (Aldehyde Dehydrogenase) to promote detoxification, , It is possible to suppress the occurrence of a hangover by promoting the discharge of toxic substances from the liver to the digestive tract and improving the movement of the ureter to discharge various toxins out of the body.

본 발명의 일실시예에 따르면, 식물혼합추출물의 조성 함량은, 식물혼합추출물 100중량% 기준으로 산청목 1~2 중량%, 뽕나무 어린가지 1~2 중량%, 헛개나무열매 2~5 중량%, 구기자나무열매 3~4 중량%, 오미자열매 1~2 중량%, 참당귀뿌리 0.1~2 중량%, 뽕나무열매 0.1~1 중량%, 계피 0.1~1 중량%, 삽주뿌리 0.1~1.5 중량%, 결명자 0.1~1.0 중량%, 산약 1~2 중량%, 왕느릅나무껍질 0.1~1.0 중량%, 건생강 0.1~1.0 중량%, 만삼뿌리 0.1~1.0 중량%, 미나리 0.1~1.0 중량%, 곶감 2~3 중량% 및 정제수 57.5~88 중량%, 바람직하게는 산청목 1.67 중량%, 뽕나무 어린가지 1.58 중량%, 헛개나무열매 2.53 중량%, 구기자나무열매 3.13 중량%, 오미자열매 1.56 중량%, 참당귀뿌리 0.78 중량%, 뽕나무열매 0.83 중량%, 계피 0.73 중량%, 삽주뿌리 0.73 중량%, 결명자 0.78 중량%, 산약 1.19 중량%, 왕느릅나무껍질 0.63 중량%, 건생강 0.47 중량%, 만삼뿌리 0.31 중량%, 미나리 0.46 중량%, 곶감 2.07 중량% 및 정제수 80.55 중량%로 이루어진다.According to one embodiment of the present invention, the compositional content of the plant mixture extract is 1 to 2% by weight of Sancheongmok, 1 to 2% by weight of mulberry young branches, 2 to 5% by weight of Hovenia raisin fruit, based on 100% by weight of the plant mixture extract. Wolfberry fruit 3-4% by weight, Schisandra chinensis fruit 1-2% by weight, Angelica gigas root 0.1-2% by weight, mulberry fruit 0.1-1% by weight, cinnamon 0.1-1% by weight, scapular root 0.1-1.5% by weight, Cassia tora 0.1 to 1.0% by weight, acid medicine 1 to 2% by weight, king elm bark 0.1 to 1.0% by weight, dried ginger 0.1 to 1.0% by weight, mansam root 0.1 to 1.0% by weight, water parsley 0.1 to 1.0% by weight, dried persimmon 2 to 3 57.5-88% by weight and purified water, preferably 1.67% by weight of Sancheongmok, 1.58% by weight of mulberry young branches, 2.53% by weight of Hovenia raisin fruit, 3.13% by weight of Goji japonica fruit, 1.56% by weight of Schisandra chinensis fruit, 0.78% by weight of Angelica gigas root %, Mulberry fruit 0.83% by weight, Cinnamon 0.73% by weight, Shovel root 0.73% by weight, Cassia tora 0.78% by weight, Acid medicine 1.19% by weight, King elm bark 0.63% by weight, Dried ginger 0.47% by weight, Mansam root 0.31% by weight, water parsley It consists of 0.46% by weight, 2.07% by weight of dried persimmon, and 80.55% by weight of purified water.

본 발명에 따른 식물혼합추출물의 조성물은 상기한 구성성분비를 가질 때, 세포독성을 나타내지 않으면서도 각 성분의 상승작용에 의해 최적의 숙취해소 및 간기능 개선 효능을 나타낸다.When the composition of the plant mixture extract according to the present invention has the above component ratio, it exhibits optimal hangover relief and liver function improvement efficacy by the synergistic action of each component without exhibiting cytotoxicity.

상기 추출물은 물, 에탄올, 메탄올, 부탄올과 같은 저급 알콜 또는 이들의 혼합용매 추출물을 포함할 수 있으며, 바람직하게는 열수 추출물이다.The extract may include a lower alcohol such as water, ethanol, methanol, or butanol, or a mixed solvent extract thereof, and is preferably a hot water extract.

우선, 식물혼합추출물을 수득하는 방법은 다음과 같다.First, a method for obtaining a mixed plant extract is as follows.

먼저, 산청목, 뽕나무 어린가지, 헛개나무열매, 구기자, 오미자, 참당귀뿌리, 뽕나무열매, 계피, 삽주뿌리줄기, 결명자, 산약, 왕느릅나무껍질, 건생강, 만삼뿌리, 미나리, 곶감을 각각 건조 후 마쇄하여 분말화 한 후, 각 분말을 산청목 1.67 중량%, 뽕나무 어린가지 1.58 중량%, 헛개나무열매 2.53 중량%, 구기자 3.13 중량%, 오미자 1.56 중량%, 참당귀뿌리 0.78 중량%, 뽕나무열매 0.83 중량%, 계피 0.73 중량%, 삽주뿌리줄기 0.73 중량%, 결명자 0.78 중량%, 산약 1.19 중량%, 왕느릅나무껍질 0.63 중량%, 건생강 0.47 중량%, 만삼뿌리 0.31 중량%, 미나리 0.46 중량%, 곶감 2.07 중량% 계측하여 혼합한다.First, Sancheongmok, mulberry young branches, hovenia tree fruit, goji berry, Schisandra chinensis, angelica root, mulberry fruit, cinnamon, shovel rhizome, gyeolmyeongja, sanyak, king elm bark, dried ginger, mansam root, water parsley, and dried persimmons are each dried. After grinding and powdering, each powder was 1.67% by weight of Sancheongmok, 1.58% by weight of young branches of mulberry, 2.53% by weight of Hovenia fruit, 3.13% by weight of Goji berry, 1.56% by weight of Schisandra chinensis, 0.78% by weight of Angelica root, 0.83% by weight of mulberry fruit Weight%, Cinnamon 0.73% by weight, Shovel rhizome 0.73% by weight, Cassia tora 0.78% by weight, Acid medicine 1.19% by weight, King elm bark 0.63% by weight, Dried ginger 0.47% by weight, Mansam root 0.31% by weight, Water parsley 0.46% by weight, Dried persimmon 2.07% by weight is measured and mixed.

상기 혼합한 혼합분말에 대략 3~5배에 달하는 부피의 물, 메탄올, 에탄올 및 부탄올과 같은 저급 알콜 또는 이들의 혼합용매, 바람직하게는 물로 100~110℃의 추출온도에서 약 1시간 ~ 3시간 동안 열수 추출로 3회 연속 추출하고 고형물을 제거한 다음 85 ~ 100 ℃에서 감압농축하여 식물혼합추출물을 수득한다.About 1 hour to 3 hours at an extraction temperature of 100 to 110 ° C. with water, lower alcohols such as methanol, ethanol and butanol, or a mixed solvent thereof, preferably water, in a volume approximately 3 to 5 times the volume of the mixed powder mixture. While extracting three times continuously by hot water extraction, solids were removed, and concentrated under reduced pressure at 85 to 100 ° C. to obtain a mixed plant extract.

또한, 배농축액은, 배를 3 cm 두께로 4 등분 분할 한 후 상온에서 0.1 ~0.3 g/L의 아황산나트륨 수용액에 10~30 분간 침지한 다음, 침지 처리된 배를 착즙하여 수득된 주스를 100 ℃의 온도에서 10~30분간 가열농축하여 배농축액을 제조하였다.In addition, the pear concentrate is divided into 4 parts with a thickness of 3 cm, immersed in 0.1 to 0.3 g/L of sodium sulfite solution at room temperature for 10 to 30 minutes, and then the juice obtained by extracting the soaked pear is 100 A pear concentrate was prepared by heating and concentrating at a temperature of ℃ for 10 to 30 minutes.

또한, 감귤추출물은 감귤류 진피를 준비하여 세척 및 건조한 후 분쇄한 다음, 분쇄된 감귤류 진피를 고온/고압의 히터 장치를 이용하여 120℃ 온도 하에 3atm의 고압 증기로 팽화 처리하였다. 이 후, 팽화 처리된 감귤류 진피를 중탕기를 이용하여 100℃의 온도에서 1시간 동안 중탕 가열한 후 20℃의 온도로 서서히 냉각시키는 과정을 3회 반복하였다.In addition, the citrus extract was prepared by washing, drying, and pulverizing the citrus dermis, and then swelling the pulverized citrus dermis with high-pressure steam of 3 atm under a temperature of 120° C. using a high-temperature/high-pressure heater. Thereafter, the process of heating the puffed citrus dermis at a temperature of 100° C. for 1 hour in a water bath using a water bath and then slowly cooling at a temperature of 20° C. was repeated three times.

전처리 된 감귤류 진피에 에탄올 수용액을 가하고 대략 85℃ 이상의 온도로 5시간 동안 가열한 후 여과 과정을 통해 고형물을 제거하여 액상의 감귤추출물을 수득하였다. An aqueous ethanol solution was added to the pretreated citrus dermis, heated at a temperature of about 85° C. or higher for 5 hours, and solids were removed through a filtration process to obtain a liquid citrus extract.

상기 수득한 식물혼합추출물 94.37 중량%와 배농축액 2.67 중량%, 감귤추출물 0.02 중량%에, 설탕 2.5 중량%, 구연산 0.17 중량%, L-아스파라진 0.17 중량%, 밀크씨슬 0.1 중량%을 가한 후, 100~110℃ 온도에서 대략 30분~1시간 열탕가열하여 숙취해소 및 간기능 개선용 혼합추출물을 제조한다.94.37% by weight of the plant mixture extract obtained above, 2.67% by weight of pear concentrate, and 0.02% by weight of citrus extract, 2.5% by weight of sugar, 0.17% by weight of citric acid, 0.17% by weight of L-asparagine, and 0.1% by weight of milk thistle were added. , Prepare a mixed extract for hangover relief and liver function improvement by heating in hot water for about 30 minutes to 1 hour at a temperature of 100 ~ 110 ℃.

본 발명에 따른 숙취해소용 조성물 제조방법은 혼합추출물을 1회 복용량인 50~75mL씩 분리하여 포장하는 단계를 추가로 포함할 수 있다. 이때, 포장용기에 담을때 85~95℃ 상태로 내열용기에 진공압축하여 포장한다. The method for preparing a composition for relieving hangover according to the present invention may further include the step of separating and packaging the mixed extract by 50 to 75 mL, which is a single dose. At this time, when packed in a packaging container, it is vacuum-compressed and packaged in a heat-resistant container at 85 to 95 ° C.

포장되는 복용량을 100mL, 120mL, ... 단위로 하여 분리 포장될 수 있음은 물론이다.It goes without saying that the dosage to be packaged may be separately packaged in units of 100mL, 120mL, ...

<실험예1><Experimental Example 1>

상기에서 제조한 숙취해소 및 간기능 개선용 조성물을 1회 복용량 50mL 씩 분리 포장하여, 성인 40명에게 제공하여 음주 전에 50mL 복용케하고 술 마신 뒤 평상시 잘 겪는 숙취 증상의 완화 여부를 조사하였다.The composition for relieving hangover and improving liver function prepared above was separately packaged at a dose of 50mL per dose, provided to 40 adults to take 50mL before drinking, and the relief of hangover symptoms commonly experienced after drinking was investigated.

성인 40명 중 8명이 평상시 음주 후 머리가 아픈 숙취 증상이 있었으나, 본 발명에 따른 숙취해소 및 간기능 개선용 조성물을 음주 전에 50mL 복용하고 술 마신 경우 8명 중 6명이 머리가 아픈 숙취 증상이 평상시 음주 후 보다 완화되었다고 응답하여, 75%의 머리가 아픈 숙취 증상 완화 비율을 보였다.Eight out of 40 adults had hangover symptoms with headaches after drinking normally, but when they drank 50mL of the composition for relieving hangover and improving liver function according to the present invention before drinking, 6 out of 8 people had hangover symptoms with headaches on a regular basis. Responding to being more relieved after drinking, 75% of hangover symptoms with headaches were relieved.

또한, 성인 40명 중 11명이 평상시 음주 후 머리가 무거운 숙취 증상이 있었으나, 본 발명에 따른 숙취해소 및 간기능 개선용 조성물을 음주 전에 50mL 복용하고 술 마신 경우 11명 중 10명이 머리가 무거운 숙취 증상이 평상시 음주 후 보다 완화되었다고 응답하여, 91%의 머리가 무거운 숙취 증상 완화 비율을 보였다.In addition, 11 out of 40 adults had hangover symptoms with heavy head after drinking normally, but when they took 50mL of the composition for relieving hangover and improving liver function according to the present invention before drinking and drank alcohol, 10 out of 11 people had hangover symptoms with heavy head. 91% of hangover symptoms were alleviated after normal drinking.

또한, 성인 40명 중 35명이 평상시 음주 후 갈증이 심한 숙취 증상이 있었으나, 본 발명에 따른 숙취해소 및 간기능 개선용 조성물을 음주 전에 50mL 복용하고 술 마신 경우 35명 중 26명이 갈증이 심한 숙취 증상이 평상시 음주 후 보다 완화되었다고 응답하여, 74%의 갈증이 심한 숙취 증상 완화 비율을 보였다.In addition, 35 out of 40 adults had hangover symptoms with severe thirst after drinking normally, but 26 out of 35 people had hangover symptoms with severe thirst after taking 50mL of the composition for relieving hangover and improving liver function according to the present invention before drinking and drinking alcohol. 74% of the respondents answered that they were alleviated after drinking normally, and showed a rate of relief from severe hangover symptoms by 74%.

또한, 성인 40명 중 24명이 평상시 음주 후 술 냄새가 심하게 나는 숙취 증상이 있었으나, 본 발명에 따른 숙취해소 및 간기능 개선용 조성물을 음주 전에 50mL 복용하고 술 마신 경우 24명 중 18명이 술 냄새가 심하게 는 숙취 증상이 평상시 음주 후 보다 완화되었다고 응답하여, 75%의 술 냄새가 심하게 나는 숙취 증상 완화비율을 보였다.In addition, 24 out of 40 adults had hangover symptoms that smelled like alcohol after drinking normally, but 18 out of 24 people who drank alcohol after taking 50mL of the composition for relieving hangover and improving liver function according to the present invention before drinking alcohol In terms of severity, hangover symptoms were alleviated after normal drinking, showing a rate of relief of hangover symptoms that smelled like alcohol at 75%.

또한, 성인 40명 중 17명이 평상시 음주 후 속이 쓰리거나 아픈 숙취 증상이 있었으나, 본 발명에 따른 숙취해소 및 간기능 개선용 조성물을 음주 전에 50mL 복용하고 술 마신 경우 17명 중 14명이 속이 쓰리거나 아픈 숙취 증상이 평상시 음주 후 보다 완화되었다고 응답하여, 82%의 속이 쓰리거나 아픈 숙취 증상 완화 비율을 보였다.In addition, 17 out of 40 adults had hangover symptoms that made them feel sore or sick after drinking normally, but 14 out of 17 people who took 50mL of the composition for relieving hangover and improving liver function according to the present invention before drinking and drank alcohol made 14 out of 17 people feel sore or sick. Respondents responded that their hangover symptoms were alleviated after normal drinking, showing 82% of hangover symptom relief rates.

또한, 성인 40명 중 23명이 평상시 음주 후 피곤을 느끼는 숙취 증상이 있었으나, 본 발명에 따른 숙취해소 및 간기능 개선용 조성물을 음주 전에 50mL 복용하고 술 마신 경우 23명 중 20명이 피곤을 느끼는 숙취 증상이 평상시 음주 후 보다 완화되었다고 응답하여, 86%의 피곤을 느끼는 숙취 증상 완화 비율을 보였다.In addition, 23 out of 40 adults had hangover symptoms that made them feel tired after drinking, but 20 out of 23 people who drank 50 mL of the composition for relieving hangover and improving liver function according to the present invention before drinking alcohol felt tired after drinking. 86% of the hangover symptom relief rate, which made people feel tired, was more relieved than after normal drinking.

이상에서 살펴본 바와 같이 본 발명에 따른 숙취해소 및 간기능 개선용 조성물은 소화기의 연동운동을 강화하여 에탄올의 소화기 내 체류시간을 줄이고, 에탄올의 체내 흡수를 줄이면서 체외 배출을 촉진하는 숙취예방의 효과, 간의 부종을 없애 간기능을 개선하고 아세트알데하이드의 분해를 촉진하며 독성물질의 체외배출을 활성화시켜 숙취발생을 억제하는 효과 및 발생된 숙취를 신속하게 해소하는 효과의 복합적 작용에 의해 다양한 숙취 증상에 범용적인 효과가 있었다.As described above, the composition for relieving hangover and improving liver function according to the present invention strengthens the peristalsis of the digestive tract, thereby reducing the residence time of ethanol in the digestive tract, and reducing the absorption of ethanol in the body while promoting excretion from the body. , It improves liver function by removing swelling of the liver, promotes the decomposition of acetaldehyde, activates the excretion of toxic substances from the body, suppresses the occurrence of hangovers, and quickly relieves hangovers. It had a universal effect.

상기에서는 본 발명의 일 실시예를 참조하여 설명하였지만, 해당 기술분야의 당업자는 이하에서 서술하는 특허 청구범위에 기재된 본 발명의 사상 및 영역으로부터 벗어나지 않는 범위 내에서 본 발명을 다양하게 수정 및 변경 실시할 수 있을 것이다. 그러므로 변형된 실시가 기본적으로 본 발명의 특허청구범위의 구성 요소를 포함한다면 모두 본 발명의 기술적 범주에 포함된다고 보아야 한다.Although the above has been described with reference to an embodiment of the present invention, those skilled in the art variously modify and change the present invention within the scope not departing from the spirit and scope of the present invention described in the claims described below. You will be able to. Therefore, if the modified implementation basically includes the elements of the claims of the present invention, all of them should be considered to be included in the technical scope of the present invention.

Claims (6)

식물혼합추출물 90~96 중량%, 배농축액 1.5~4.5 중량%, 설탕 1.0~3.5 중량%, 구연산 0.1~1.0 중량%, L-아스파라진 0.1~1.0 중량%, 밀크씨슬 0.05~0.3 중량%, 감귤추출물 0.01~0.05 중량%가 유효성분으로 포함되는 것을 특징으로 하는 숙취해소 및 간기능 개선용 조성물.
90-96% by weight of plant mixture extract, 1.5-4.5% by weight of pear concentrate, 1.0-3.5% by weight of sugar, 0.1-1.0% by weight of citric acid, 0.1-1.0% by weight of L-asparagine, 0.05-0.3% by weight of milk thistle, A composition for relieving hangover and improving liver function, characterized in that 0.01 to 0.05% by weight of citrus extract is included as an active ingredient.
 제 1항에 있어서,
상기 식물혼합추출물은 산청목, 뽕나무 어린가지, 헛개나무열매, 구기자, 오미자, 참당귀뿌리, 뽕나무열매, 계피, 삽주뿌리, 결명자, 산약, 왕느릅나무껍질, 건생강, 만삼뿌리, 미나리, 곶감을 유효성분으로 포함되는 것을 특징으로 하는 숙취해소 및 간기능 개선용 조성물.
According to claim 1,
The plant mixture extract is Sancheongmok, mulberry young branches, barberry fruit, goji berry, Schisandra chinensis, angelica root, mulberry fruit, cinnamon, shovel root, gyeolmyeongja, mountain medicine, king elm bark, dried ginger, mansam root, water parsley, dried persimmon A composition for relieving hangover and improving liver function, characterized in that it is included as an active ingredient.
 제 1항 또는 제 2항에 있어서,
상기 식물혼합추출물은, 상기 식물혼합추출물 100중량% 기준으로 산청목 1~2 중량%, 뽕나무 어린가지 1~2 중량%, 헛개나무열매 2~5 중량%, 구기자나무열매 3~4 중량%, 오미자열매 1~2 중량%, 참당귀뿌리 0.1~2 중량%, 뽕나무열매 0.1~1 중량%, 계피 0.1~1 중량%, 삽주뿌리 0.1~1.5 중량%, 결명자 0.1~1.0 중량%, 산약 1~2 중량%, 왕느릅나무껍질 0.1~1.0 중량%, 건생강 0.1~1.0 중량%, 만삼뿌리 0.1~1.0 중량%, 미나리 0.1~1.0 중량%, 곶감 2~3 중량% 및 정제수 57.5~88 중량%로 이루어지는 것을 특징으로 하는 숙취해소 및 간기능 개선용 조성물.
According to claim 1 or 2,
The plant mixture extract is, based on 100% by weight of the plant mixture extract, 1 to 2% by weight of Sancheongmok, 1 to 2% by weight of mulberry young branches, 2 to 5% by weight of Hovenia tree fruit, 3 to 4% by weight of Goji japonica fruit, Schisandra chinensis Fruit 1-2% by weight, Angelica gigas root 0.1-2% by weight, Mulberry fruit 0.1-1% by weight, Cinnamon 0.1-1% by weight, Shovel root 0.1-1.5% by weight, Cassia tora 0.1-1.0% by weight, Acid medicine 1-2 % by weight, king elm bark 0.1-1.0% by weight, dried ginger 0.1-1.0% by weight, mansam root 0.1-1.0% by weight, water parsley 0.1-1.0% by weight, dried persimmon 2-3% by weight and purified water 57.5-88% by weight A composition for relieving hangover and improving liver function, characterized in that consisting of.
 제 1항 또는 제 2항에 있어서,
상기 식물혼합추출물은, 상기 식물혼합추출물 100중량% 기준으로 산청목 1.67 중량%, 뽕나무 어린가지 1.58 중량%, 헛개나무열매 2.53 중량%, 구기자나무열매 3.13 중량%, 오미자열매 1.56 중량%, 참당귀뿌리 0.78 중량%, 뽕나무열매 0.83 중량%, 계피 0.73 중량%, 삽주뿌리 0.73 중량%, 결명자 0.78 중량%, 산약 1.19 중량%, 왕느릅나무껍질 0.63 중량%, 건생강 0.47 중량%, 만삼뿌리 0.31 중량%, 미나리 0.46 중량%, 곶감 2.07 중량% 및 정제수 80.55 중량%로 이루어지는 것을 특징으로 하는 숙취해소 및 간기능 개선용 조성물.
According to claim 1 or 2,
The plant mixture extract, based on 100% by weight of the plant mixture extract, 1.67% by weight of Sancheongmok, 1.58% by weight of mulberry young branches, 2.53% by weight of Hovenia japonica fruit, 3.13% by weight of Goji japonica fruit, 1.56% by weight of Schisandra chinensis fruit, 0.78% by weight, 0.83% by weight of mulberry fruit, 0.73% by weight of cinnamon, 0.73% by weight of shovel root, 0.78% by weight of Cassia tora, 1.19% by weight of acid medicine, 0.63% by weight of king elm bark, 0.47% by weight of dry ginger, 0.31% by weight of mansam root A composition for relieving hangover and improving liver function, characterized in that it consists of 0.46% by weight of water parsley, 2.07% by weight of dried persimmon, and 80.55% by weight of purified water.
 식물혼합추출물 100중량% 기준으로, 산청목 1.67 중량%, 뽕나무 어린가지 1.58 중량%, 헛개나무열매 2.53 중량%, 구기자나무열매 3.13 중량%, 오미자열매 1.56 중량%, 참당귀뿌리 0.78 중량%, 뽕나무열매 0.83 중량%, 계피 0.73 중량%, 삽주뿌리 0.73 중량%, 결명자 0.78 중량%, 산약 1.19 중량%, 왕느릅나무껍질 0.63 중량%, 건생강 0.47 중량%, 만삼뿌리 0.31 중량%, 미나리 0.46 중량%, 곶감 2.07 중량% 및 정제수 80.55 중량%로 이루어진 식물혼합추출물 94.37 중량%;
배농축액 2.67 중량%;
갈색설탕 2.5 중량%;
구연산 0.17 중량%;
L-아스파라진 0.17 중량%;
밀크씨슬 0.1 중량%; 및
감귤추출물 0.02 중량%;를 유효성분으로 포함하는 것을 특징으로 하는 숙취해소 및 간기능 개선용 조성물.
Based on 100% by weight of plant mixture extract, 1.67% by weight of Sancheongmok, 1.58% by weight of young branches of mulberry, 2.53% by weight of Hovenia fruit, 3.13% by weight of Goji japonica fruit, 1.56% by weight of Schisandra chinensis fruit, 0.78% by weight of Angelica root, mulberry fruit 0.83% by weight, cinnamon 0.73% by weight, shovel root 0.73% by weight, Cassia tora 0.78% by weight, acid medicine 1.19% by weight, king elm bark 0.63% by weight, dried ginger 0.47% by weight, mansam root 0.31% by weight, parsley 0.46% by weight, 94.37% by weight of a plant mixture extract consisting of 2.07% by weight of dried persimmon and 80.55% by weight of purified water;
2.67% by weight of pear concentrate;
2.5% by weight of brown sugar;
0.17% by weight of citric acid;
0.17% by weight of L-asparagine;
0.1% by weight of milk thistle; and
A composition for relieving hangover and improving liver function, comprising 0.02% by weight of citrus extract as an active ingredient.
 산청목, 뽕나무 어린가지, 헛개나무열매, 구기자, 오미자, 참당귀뿌리, 뽕나무열매, 계피, 삽주뿌리줄기, 결명자, 산약, 왕느릅나무껍질, 건생강, 만삼뿌리, 미나리, 곶감을 각각 건조 후 마쇄하여 분말화 한 후, 각 분말을 산청목 1.67 중량%, 뽕나무 어린가지 1.58 중량%, 헛개나무열매 2.53 중량%, 구기자 3.13 중량%, 오미자 1.56 중량%, 참당귀뿌리 0.78 중량%, 뽕나무열매 0.83 중량%, 계피 0.73 중량%, 삽주뿌리줄기 0.73 중량%, 결명자 0.78 중량%, 산약 1.19 중량%, 왕느릅나무껍질 0.63 중량%, 건생강 0.47 중량%, 만삼뿌리 0.31 중량%, 미나리 0.46 중량%, 곶감 2.07 중량% 계측하여 혼합하는 단계;
상기 혼합한 혼합분말에 3~5배의 물을 첨가한 후 100~110℃의 추출온도에서 1시간 ~ 3시간 동안 열수 추출하고 고형물을 제거한 다음 감압농축하여 식물혼합추출물을 수득하는 단계;
배를 아황산나트륨 수용액에 10~30 분간 침지한 다음, 침지 처리된 배를 착즙하여 수득된 주스를 100 ℃의 온도에서 10~30분간 가열농축하여 배농축액을 제조하는 단계;
감귤류 진피를 준비하여 세척 및 건조한 후 분쇄하고 중탕 가열한 후 냉각시키고, 재차 가열한 후 여과 과정을 통해 고형물을 제거하여 액상의 감귤추출물을 수득하는 단계; 및
상기 수득한 식물혼합추출물 94.37 중량%와 배농축액 2.67 중량%, 감귤추출물 0.02 중량%에, 설탕 2.5 중량%, 구연산 0.17 중량%, L-아스파라진 0.17 중량%, 밀크씨슬 0.1 중량%을 가한 후, 100~110℃ 온도에서 30분~1시간 열탕가열하여 숙취해소 및 간기능 개선용 혼합추출물을 제조하는 단계;를 포함하여 구성되는 것을 특징으로 하는 숙취해소 및 간기능 개선용 조성물 제조방법.Sancheongmok, mulberry young branch, hovenia tree fruit, goji berry, Schisandra chinensis, angelica root, mulberry fruit, cinnamon, shovel rhizome, gyeolseongja, sanyak, king elm bark, dried ginger, mansam root, water parsley, dried persimmon are dried and ground After powdering, each powder was 1.67% by weight of Sancheongmok, 1.58% by weight of mulberry young branches, 2.53% by weight of Hovenia fruit, 3.13% by weight of goji berry, 1.56% by weight of Schisandra chinensis, 0.78% by weight of Angelica root, 0.83% by weight of mulberry fruit , Cinnamon 0.73% by weight, shovel rhizome 0.73% by weight, Cassia tora 0.78% by weight, acid medicine 1.19% by weight, king elm bark 0.63% by weight, dried ginger 0.47% by weight, mansam root 0.31% by weight, parsley 0.46% by weight, dried persimmon 2.07 Mixing by measuring weight %;
Obtaining a mixed plant extract by adding 3 to 5 times of water to the mixed powder, performing hot water extraction at an extraction temperature of 100 to 110 ° C. for 1 hour to 3 hours, removing solids, and then concentrating under reduced pressure;
Preparing a pear concentrate by immersing pears in an aqueous solution of sodium sulfite for 10 to 30 minutes and then heating and concentrating the juice obtained by squeezing the soaked pears at a temperature of 100 ° C. for 10 to 30 minutes;
Preparing citrus dermis, washing, drying, pulverizing, heating in a water bath, cooling, heating again, and removing solids through filtration to obtain a liquid citrus extract; and
94.37% by weight of the plant mixture extract obtained above, 2.67% by weight of pear concentrate, and 0.02% by weight of citrus extract, 2.5% by weight of sugar, 0.17% by weight of citric acid, 0.17% by weight of L-asparagine, and 0.1% by weight of milk thistle were added. , preparing a mixed extract for relieving hangover and improving liver function by heating in hot water for 30 minutes to 1 hour at a temperature of 100 to 110 ° C.
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Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR920019344A (en) 1991-04-10 1992-11-19 이순목 Prevention and treatment composition of liver disease using α-linolenic acid
KR19980048620A (en) 1996-12-18 1998-09-15 박명규 Liver function improving agent containing isoflavone derived from Astragalus
KR20000061327A (en) 1999-03-25 2000-10-16 김상조 Natural pharmaceutical composition for prevention and treatment of hepatic disease.
KR20020029036A (en) 2002-03-26 2002-04-17 김성도 A process for preparing beverage of honenia dulcis
KR20030019591A (en) 2001-05-22 2003-03-06 코닌클리케 필립스 일렉트로닉스 엔.브이. Projection display device
KR20040052261A (en) 2002-12-16 2004-06-23 민상규 Method for production of drink comprising extract of hovenia dulcis enhanced with Vitamin C
KR20050078080A (en) 2004-01-30 2005-08-04 김판현 Pharmaceutical composition for treating arthritis and method for making

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR920019344A (en) 1991-04-10 1992-11-19 이순목 Prevention and treatment composition of liver disease using α-linolenic acid
KR19980048620A (en) 1996-12-18 1998-09-15 박명규 Liver function improving agent containing isoflavone derived from Astragalus
KR20000061327A (en) 1999-03-25 2000-10-16 김상조 Natural pharmaceutical composition for prevention and treatment of hepatic disease.
KR20030019591A (en) 2001-05-22 2003-03-06 코닌클리케 필립스 일렉트로닉스 엔.브이. Projection display device
KR20020029036A (en) 2002-03-26 2002-04-17 김성도 A process for preparing beverage of honenia dulcis
KR20040052261A (en) 2002-12-16 2004-06-23 민상규 Method for production of drink comprising extract of hovenia dulcis enhanced with Vitamin C
KR20050078080A (en) 2004-01-30 2005-08-04 김판현 Pharmaceutical composition for treating arthritis and method for making

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