KR20230052915A - 케타민을 포함하는 미소 구체 제제 및 이의 제조 방법 및 사용 방법 - Google Patents
케타민을 포함하는 미소 구체 제제 및 이의 제조 방법 및 사용 방법 Download PDFInfo
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- KR20230052915A KR20230052915A KR1020237008093A KR20237008093A KR20230052915A KR 20230052915 A KR20230052915 A KR 20230052915A KR 1020237008093 A KR1020237008093 A KR 1020237008093A KR 20237008093 A KR20237008093 A KR 20237008093A KR 20230052915 A KR20230052915 A KR 20230052915A
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- South Korea
- Prior art keywords
- microsphere
- ketamine
- polymeric
- polymeric microspheres
- polymer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000004005 microsphere Substances 0.000 title claims abstract description 214
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
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- A—HUMAN NECESSITIES
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Dermatology (AREA)
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| PCT/US2021/046220 WO2022040130A1 (en) | 2020-08-18 | 2021-08-17 | Microsphere formulations comprising ketamine and methods for making and using the same |
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| EP4611729A1 (en) * | 2022-10-31 | 2025-09-10 | Oakwood Laboratories, LLC | Mixed release profile polymer microsphere formulations comprising octreotide and methods for making and using the same |
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| US6270802B1 (en) | 1998-10-28 | 2001-08-07 | Oakwood Laboratories L.L.C. | Method and apparatus for formulating microspheres and microcapsules |
| US6291013B1 (en) * | 1999-05-03 | 2001-09-18 | Southern Biosystems, Inc. | Emulsion-based processes for making microparticles |
| AU6510400A (en) | 1999-08-04 | 2001-03-05 | Oakwood Laboratories L.L.C. | Slow release microspheres |
| US6479007B1 (en) | 1999-09-16 | 2002-11-12 | University Technology Corporation | Apparatus and method for controlling pore size in polymeric membranes and thin films |
| KR100392501B1 (ko) | 2000-06-28 | 2003-07-22 | 동국제약 주식회사 | 다중 에멀젼법에 의한 서방출성 미립구의 제조방법 |
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| KR101271263B1 (ko) | 2005-09-28 | 2013-06-07 | 아우리스 메디칼 아게 | 내이 장애 치료용 약학 조성물 |
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| KR20240011237A (ko) | 2017-12-22 | 2024-01-25 | 얀센 파마슈티카 엔브이 | 우울증 치료를 위한 에스케타민 |
| EP3968979A4 (en) | 2019-05-15 | 2023-03-01 | Bexson Biomedical, Inc. | KETAMINE FORMULATION FOR SUBCUTANEOUS INJECTION |
| EP3993898B1 (en) | 2019-07-01 | 2025-10-15 | Oakwood Laboratories, Llc | System and method for making microspheres and emulsions |
| US20220401366A1 (en) * | 2019-11-15 | 2022-12-22 | Consegna Pharma, Inc. | Long acting nmda antagonists |
| PH12022550775A1 (en) | 2019-12-20 | 2023-08-23 | Alar Pharmaceuticals Inc | Long-acting injectable formulations of ketamine pamoate salts |
| US20210361578A1 (en) | 2020-04-03 | 2021-11-25 | University Of Iowa Research Foundation | Mek1/2 inhibitor-loaded microparticle formulation |
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| JP7814375B2 (ja) | 2026-02-16 |
| AU2021329820A1 (en) | 2023-03-09 |
| CN115942935B (zh) | 2025-09-05 |
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