KR20230044358A - 피리미딘 화합물의 염 및 결정형, 및 그의 제조 방법 - Google Patents

피리미딘 화합물의 염 및 결정형, 및 그의 제조 방법 Download PDF

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Publication number
KR20230044358A
KR20230044358A KR1020227041673A KR20227041673A KR20230044358A KR 20230044358 A KR20230044358 A KR 20230044358A KR 1020227041673 A KR1020227041673 A KR 1020227041673A KR 20227041673 A KR20227041673 A KR 20227041673A KR 20230044358 A KR20230044358 A KR 20230044358A
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KR
South Korea
Prior art keywords
compound
salt
xrpd pattern
fumarate salt
diffraction peaks
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Pending
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KR1020227041673A
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English (en)
Korean (ko)
Inventor
정 공
홍밍 리
시동 이
롱 리
톈밍 왕
핑윤 천
청시 왕
타오 왕
야오야오 송
지앙펑 저우
유펑 리앙
중후이 천
치앙 티안
홍메이 송
통통 쉐
징이 왕
Original Assignee
쓰촨 케룬-바이오테크 바이오파마수티컬 컴퍼니 리미티드
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Application filed by 쓰촨 케룬-바이오테크 바이오파마수티컬 컴퍼니 리미티드 filed Critical 쓰촨 케룬-바이오테크 바이오파마수티컬 컴퍼니 리미티드
Publication of KR20230044358A publication Critical patent/KR20230044358A/ko
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
    • C07C309/30—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings of six-membered aromatic rings substituted by alkyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13—Dicarboxylic acids
    • C07C57/15—Fumaric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020227041673A 2020-07-28 2021-07-23 피리미딘 화합물의 염 및 결정형, 및 그의 제조 방법 Pending KR20230044358A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN202010737039 2020-07-28
CN202010737039.7 2020-07-28
PCT/CN2021/108032 WO2022022398A1 (zh) 2020-07-28 2021-07-23 一种嘧啶类化合物的盐和晶型及其制备方法

Publications (1)

Publication Number Publication Date
KR20230044358A true KR20230044358A (ko) 2023-04-04

Family

ID=80037147

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020227041673A Pending KR20230044358A (ko) 2020-07-28 2021-07-23 피리미딘 화합물의 염 및 결정형, 및 그의 제조 방법

Country Status (7)

Country Link
US (1) US20230295174A1 (https=)
EP (1) EP4190781A4 (https=)
JP (1) JP7688690B2 (https=)
KR (1) KR20230044358A (https=)
CN (1) CN115702154A (https=)
BR (1) BR112023000065A2 (https=)
WO (1) WO2022022398A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN120897743A (zh) * 2023-05-19 2025-11-04 四川科伦博泰生物医药股份有限公司 杂环化合物治疗与ret基因改变相关疾病的用途和方法
WO2026017002A1 (zh) * 2024-07-16 2026-01-22 四川科伦博泰生物医药股份有限公司 以杂环化合物为活性成分的药物组合物、其制备方法及用途
GB202410599D0 (en) 2024-07-19 2024-09-04 Ellipses Pharma Ltd Therapeutics useful synergistic combinations

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008525422A (ja) * 2004-12-23 2008-07-17 ファイザー・プロダクツ・インク 抗癌剤として有用な複素芳香族誘導体
US20080234267A1 (en) * 2007-03-20 2008-09-25 Karen Elizabeth Lackey Compounds and Methods of Treatment
BR112018000808A2 (pt) * 2015-07-16 2018-09-04 Array Biopharma Inc compostos de pirazolo[1,5-a]piridina substituída como inibidores de ret cinase
WO2018136661A1 (en) * 2017-01-18 2018-07-26 Andrews Steven W SUBSTITUTED PYRAZOLO[1,5-a]PYRAZINE COMPOUNDS AS RET KINASE INHIBITORS
WO2020114388A1 (zh) * 2018-12-06 2020-06-11 深圳市塔吉瑞生物医药有限公司 取代的吡唑并[1,5-a]吡啶化合物及包含该化合物的组合物及其用途
CN111285882B (zh) * 2018-12-07 2022-12-02 四川科伦博泰生物医药股份有限公司 稠环化合物、包含其的药物组合物及其制备方法和用途
JP7615056B2 (ja) * 2019-02-19 2025-01-16 スーチュアン・コールン－バイオテック・バイオファーマシューティカル・カンパニー・リミテッド 複素環化合物、これを含む薬物組成物、その製造方法および使用
KR20230159367A (ko) 2021-03-24 2023-11-21 쓰촨 케룬-바이오테크 바이오파마수티컬 컴퍼니 리미티드 키나아제 약물 내성 돌연변이와 관련된 질병의 치료에있어서의 헤테로사이클릭 화합물의 용도 및 그 방법

Also Published As

Publication number Publication date
JP2023535361A (ja) 2023-08-17
JP7688690B2 (ja) 2025-06-04
CN115702154A (zh) 2023-02-14
EP4190781A4 (en) 2023-12-27
WO2022022398A1 (zh) 2022-02-03
BR112023000065A2 (pt) 2023-01-31
US20230295174A1 (en) 2023-09-21
EP4190781A1 (en) 2023-06-07

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