KR20230042408A - 암에 대한 면역요법에 사용하기 위한 펩티드 및 펩티드의 조합 - Google Patents

암에 대한 면역요법에 사용하기 위한 펩티드 및 펩티드의 조합 Download PDF

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KR20230042408A
KR20230042408A KR1020237009287A KR20237009287A KR20230042408A KR 20230042408 A KR20230042408 A KR 20230042408A KR 1020237009287 A KR1020237009287 A KR 1020237009287A KR 20237009287 A KR20237009287 A KR 20237009287A KR 20230042408 A KR20230042408 A KR 20230042408A
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peptide
cancer
cell
cells
carcinoma
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안드레아 마르
올리버 슈르
토니 바인쉥크
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이매틱스 바이오테크놀로지스 게엠베하
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    • A61K40/11T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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KR1020237009287A 2016-03-16 2017-03-14 암에 대한 면역요법에 사용하기 위한 펩티드 및 펩티드의 조합 Ceased KR20230042408A (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201662309107P 2016-03-16 2016-03-16
GB1604490.1 2016-03-16
GBGB1604490.1A GB201604490D0 (en) 2016-03-16 2016-03-16 Peptides combination of peptides for use in immunotherapy against cancers
US62/309,107 2016-03-16
PCT/EP2017/055973 WO2017157928A1 (en) 2016-03-16 2017-03-14 Peptides and combination of peptides for use in immunotherapy against cancers
KR1020187029680A KR20180127642A (ko) 2016-03-16 2017-03-14 암에 대한 면역요법에 사용하기 위한 펩티드 및 펩티드의 조합

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KR1020187029680A Division KR20180127642A (ko) 2016-03-16 2017-03-14 암에 대한 면역요법에 사용하기 위한 펩티드 및 펩티드의 조합

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KR1020237009287A Ceased KR20230042408A (ko) 2016-03-16 2017-03-14 암에 대한 면역요법에 사용하기 위한 펩티드 및 펩티드의 조합
KR1020187029680A Ceased KR20180127642A (ko) 2016-03-16 2017-03-14 암에 대한 면역요법에 사용하기 위한 펩티드 및 펩티드의 조합

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US (5) US10512679B2 (https=)
EP (1) EP3429617A1 (https=)
JP (2) JP2019515653A (https=)
KR (2) KR20230042408A (https=)
CN (1) CN108883165A (https=)
AU (2) AU2017234174B2 (https=)
BR (1) BR112018068489A2 (https=)
CA (1) CA3017652A1 (https=)
GB (1) GB201604490D0 (https=)
IL (1) IL261786A (https=)
MX (1) MX2018011220A (https=)
WO (1) WO2017157928A1 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201604490D0 (en) * 2016-03-16 2016-04-27 Immatics Biotechnologies Gmbh Peptides combination of peptides for use in immunotherapy against cancers
WO2018225063A1 (en) * 2017-06-04 2018-12-13 Rappaport Family Institute For Research In The Medical Sciences Method of predicting personalized response to cancer treatment with immune checkpoint inhibitors and kits therefor
CN109584966B (zh) * 2019-01-08 2019-09-20 杭州纽安津生物科技有限公司 一种肿瘤通用疫苗的设计方法及胰腺癌通用疫苗
DE102019114735A1 (de) * 2019-06-02 2020-12-03 PMCR GmbH HLA-Tumorantigenpeptiden der Klasse I und II zur Behandlung von Mamma-/Brustkarzinomen
BR112021025943A2 (pt) * 2019-06-25 2022-02-08 Univ Montreal Antígenos específicos de tumor inovadores para câncer de ovário e usos dos mesmos
CN112521484A (zh) * 2020-12-03 2021-03-19 佛山市第一人民医院(中山大学附属佛山医院) 结肠癌肿瘤特异tcr序列及其应用
CN114133432B (zh) * 2021-11-01 2023-06-16 暨南大学 一种抑制肿瘤细胞生长和转移的靶向肽及其应用
CN116514909B (zh) * 2022-08-16 2024-06-18 河南科技大学 一种抗肿瘤活性多肽及其制备方法与应用
CN115490754B (zh) * 2022-10-13 2024-04-26 河南科技大学 一种抗肿瘤活性多肽衍生物及其制备方法与应用
CN117192115A (zh) * 2023-11-03 2023-12-08 赛德特(北京)生物工程有限公司 检测t淋巴细胞免疫活性的方法
CN117552115B (zh) * 2024-01-12 2024-03-26 天津鲸鹏生物科技有限责任公司 用于诱导肿瘤特异性免疫响应的通用型抗原肽库及其应用

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030138438A1 (en) 1998-03-18 2003-07-24 Corixa Corporation Compositions and methods for the therapy and diagnosis of lung cancer
US20030236209A1 (en) 1998-03-18 2003-12-25 Corixa Corporation Compositions and methods for the therapy and diagnosis of lung cancer
US6436703B1 (en) 2000-03-31 2002-08-20 Hyseq, Inc. Nucleic acids and polypeptides
AU2001279581A1 (en) 2000-09-06 2002-03-22 Friederike Muller Medicament comprising a dna sequence, which codes for the rna-binding koc protein, and comprising a koc protein or dna sequence of the koc promoter
US7919467B2 (en) * 2000-12-04 2011-04-05 Immunotope, Inc. Cytotoxic T-lymphocyte-inducing immunogens for prevention, treatment, and diagnosis of cancer
EP2113253B1 (en) 2008-04-30 2010-03-31 Immatics Biotechnologies GmbH Novel formulations of tumour-associated peptides binding to human leukocyte antigen (HLA) class I or II molecules for vaccines
US20100037514A1 (en) 2008-05-13 2010-02-18 Afton Chemical Corporation Fuel additives to maintain optimum injector performance
ES2532896T5 (es) * 2008-05-14 2018-03-20 Immatics Biotechnologies Gmbh Péptidos del MHC de clase II novedosos y potentes derivados de survivina y neurocan
RS53782B1 (sr) 2008-10-01 2015-06-30 Immatics Biotechnologies Gmbh Preparati tumor-asociranih peptida i odgovarajuća antikancerska vakcina za tretman glioblastoma (gbm) i drugih kancera
US8253536B2 (en) 2009-04-22 2012-08-28 Simon Fraser University Security document with electroactive polymer power source and nano-optical display
TW201124530A (en) * 2009-12-01 2011-07-16 Oncotherapy Science Inc IMP-3 oligopeptides and vaccines including the same
US8845620B2 (en) 2010-03-16 2014-09-30 Adapta Medical, Inc. Catheter reservoir seals
GB201004551D0 (en) * 2010-03-19 2010-05-05 Immatics Biotechnologies Gmbh NOvel immunotherapy against several tumors including gastrointestinal and gastric cancer
GB201015765D0 (en) 2010-09-21 2010-10-27 Immatics Biotechnologies Gmbh Use of myeloid cell biomarkers for the diagnosis of cancer
PL2633020T3 (pl) 2010-10-25 2019-10-31 Stepan Co Detergenty do prania na bazie kompozycji pochodzących z metatezy naturalnego oleju
GB201021289D0 (en) 2010-12-15 2011-01-26 Immatics Biotechnologies Gmbh Novel biomarkers for a prediction of the outcome of an immunotherapy against cancer
ES2617983T3 (es) 2011-01-10 2017-06-20 Ct Atlantic Ltd. Terapia de combinación que incluye anticuerpos de unión a antígenos asociados a tumores
WO2014089124A1 (en) 2012-12-03 2014-06-12 Cenexys, Inc. Immunogenic compositions for inducing an immune response for elimination of senescent cells
WO2014088432A1 (en) 2012-12-06 2014-06-12 Callaghan Innovation Research Limited Conjugate compounds
CA3051222C (en) 2013-06-10 2023-01-24 Dana-Farber Cancer Institute, Inc. Methods and compositions for reducing immunosupression by tumor cells
GB201319446D0 (en) * 2013-11-04 2013-12-18 Immatics Biotechnologies Gmbh Personalized immunotherapy against several neuronal and brain tumors
ES2738582T3 (es) 2014-02-14 2020-01-23 Immune Design Corp Inmunoterapia del cáncer a través de combinación de inmunoestimulación local y sistémica
ES2900262T3 (es) 2014-03-17 2022-03-16 Bundesrepublik Deutschland Letztvertreten Durch Das Robert Koch Inst Vertreten Durch Seinen Praeside Un medicamento para el uso en un método para inducir o extender una respuesta inmunitaria citotóxica celular
JP2015227292A (ja) 2014-05-30 2015-12-17 国立大学法人高知大学 膵がん細胞浸潤転移抑制ワクチン
WO2015187040A1 (en) 2014-06-05 2015-12-10 Regan James Anderson Amino sphingoglycolipid analogues
GB201504502D0 (en) 2015-03-17 2015-04-29 Immatics Biotechnologies Gmbh Novel peptides and combination of peptides for use in immunotherapy against pancreatic cancer and other cancers
LT3388075T (lt) * 2015-03-27 2023-11-10 Immatics Biotechnologies Gmbh Nauji peptidai ir peptidų deriniai, skirti naudoti imunoterapijai prieš įvairius navikus (seq id 25 - mrax5-003)
GB201505305D0 (en) * 2015-03-27 2015-05-13 Immatics Biotechnologies Gmbh Novel Peptides and combination of peptides for use in immunotherapy against various tumors
GB201505585D0 (en) * 2015-03-31 2015-05-13 Immatics Biotechnologies Gmbh Novel peptides and combination of peptides and scaffolds for use in immunotherapy against renal cell carinoma (RCC) and other cancers
GB201507030D0 (en) * 2015-04-24 2015-06-10 Immatics Biotechnologies Gmbh Immunotherapy against lung cancers, in particular NSCLC
GB201507719D0 (en) 2015-05-06 2015-06-17 Immatics Biotechnologies Gmbh Novel peptides and combination of peptides and scaffolds thereof for use in immunotherapy against colorectal carcinoma (CRC) and other cancers
IL308202A (en) * 2015-05-06 2024-01-01 Immatics Biotechnologies Gmbh Novel peptides and combination of oeptides and scaffolds thereof for use in immunotherapy against colorectal carcinoma (CRC) and other cancers
GB201510771D0 (en) * 2015-06-19 2015-08-05 Immatics Biotechnologies Gmbh Novel peptides and combination of peptides for use in immunotherapy and methods for generating scaffolds for the use against pancreatic cancer
TW202231659A (zh) * 2015-06-19 2022-08-16 德商英麥提克生物技術股份有限公司 用於免疫治療的新穎胜肽及胜肽組合物與產生用於抗胰臟癌及其他癌症的支架的方法
GB201511546D0 (en) 2015-07-01 2015-08-12 Immatics Biotechnologies Gmbh Novel peptides and combination of peptides for use in immunotherapy against ovarian cancer and other cancers
MA54884A (fr) * 2015-07-01 2022-01-12 Immatics Biotechnologies Gmbh Neuartige peptide und kombination aus peptiden zur verwendung in der immuntherapie gegen ovarialkarzinom und andere karzinome
GB201521746D0 (en) * 2015-12-10 2016-01-27 Immatics Biotechnologies Gmbh Novel peptides and combination of peptides for use in immunotherapy against CLL and other cancers
GB201604494D0 (en) 2016-03-16 2016-04-27 Immatics Biotechnologies Gmbh Transfected T-Cells and T-Cell receptors for use in immunotherapy against cancers
NZ746387A (en) * 2016-03-16 2022-08-26 Immatics Biotechnologies Gmbh Transfected t-cells and t-cell receptors for use in immunotherapy against cancers
GB201604490D0 (en) * 2016-03-16 2016-04-27 Immatics Biotechnologies Gmbh Peptides combination of peptides for use in immunotherapy against cancers
WO2017174645A1 (en) 2016-04-06 2017-10-12 Immatics Biotechnologies Gmbh Novel peptides and combination of peptides for use in immunotherapy against aml and other cancers
GB201609193D0 (en) 2016-05-25 2016-07-06 Immatics Biotechnologies Gmbh Novel peptides, combination of peptides as targets for use in immunotherapy against gallbladder cancer and cholangiocarcinoma and other cancers
TWI796299B (zh) 2016-08-26 2023-03-21 德商英麥提克生物技術股份有限公司 用於頭頸鱗狀細胞癌和其他癌症免疫治療的新型肽和支架
SG11201911430PA (en) 2017-07-04 2020-01-30 Curevac Ag Novel nucleic acid molecules
CN111315769A (zh) 2017-09-06 2020-06-19 加州理工学院 信号传导和抗原呈递双功能受体(sabr)
WO2020072700A1 (en) 2018-10-02 2020-04-09 Dana-Farber Cancer Institute, Inc. Hla single allele lines
JP2022096002A (ja) 2019-04-25 2022-06-29 三洋化成工業株式会社 アルカリ電池用ゲル化剤及びアルカリ電池
AU2020356334A1 (en) 2019-09-24 2022-03-31 Université Catholique de Louvain Modified vesicular stomatitis virus glycoprotein and uses thereof for the treatment of brain tumors
US12394502B2 (en) 2019-10-02 2025-08-19 The General Hospital Corporation Method for predicting HLA-binding peptides using protein structural features

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IL261786A (en) 2018-10-31
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AU2017234174B2 (en) 2021-09-09
GB201604490D0 (en) 2016-04-27
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