KR20230029671A - 항-인간 nr1 항체 유도체 - Google Patents

항-인간 nr1 항체 유도체 Download PDF

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KR20230029671A
KR20230029671A KR1020227045463A KR20227045463A KR20230029671A KR 20230029671 A KR20230029671 A KR 20230029671A KR 1020227045463 A KR1020227045463 A KR 1020227045463A KR 20227045463 A KR20227045463 A KR 20227045463A KR 20230029671 A KR20230029671 A KR 20230029671A
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amino acid
seq
polynucleotide
acid sequence
sequence encoding
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사토시 구보
아츠오 간노
다이스케 야마주쿠
다쿠야 기토
마사시 마에다
다쿠마 미하라
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아리아리스 테라퓨틱스, 인크.
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    • A61P25/00—Drugs for disorders of the nervous system
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/286—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against neuromediator receptors, e.g. serotonin receptor, dopamine receptor
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    • C12N15/09—Recombinant DNA-technology
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    • C12N15/62—DNA sequences coding for fusion proteins
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    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N5/0681—Cells of the genital tract; Non-germinal cells from gonads
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C—CHEMISTRY; METALLURGY
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    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Reproductive Health (AREA)
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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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KR1020227045463A 2020-05-27 2021-05-26 항-인간 nr1 항체 유도체 Pending KR20230029671A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JPJP-P-2020-092105 2020-05-27
JP2020092105 2020-05-27
PCT/JP2021/019929 WO2021241616A1 (ja) 2020-05-27 2021-05-26 抗ヒトｎｒ１抗体誘導体

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KR20230029671A true KR20230029671A (ko) 2023-03-03

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US (2) US20230220070A1 (https=)
EP (1) EP4159859A4 (https=)
JP (1) JPWO2021241616A1 (https=)
KR (1) KR20230029671A (https=)
CN (2) CN120737200A (https=)
AU (1) AU2021281828A1 (https=)
BR (1) BR112022023931A2 (https=)
CA (1) CA3180470A1 (https=)
IL (1) IL298537A (https=)
MX (1) MX2022014856A (https=)
WO (1) WO2021241616A1 (https=)

Families Citing this family (5)

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Publication number Priority date Publication date Assignee Title
WO2021241616A1 (ja) 2020-05-27 2021-12-02 アステラス製薬株式会社 抗ヒトｎｒ１抗体誘導体
JP7730432B2 (ja) 2022-10-19 2025-08-27 アステラス製薬株式会社 がん治療におけるｐｄ－１シグナル阻害剤との組み合わせによる抗ｃｌｄｎ４－抗ｃｄ１３７二重特異性抗体の使用
AU2024242885A1 (en) * 2023-03-30 2025-09-11 Arialys Therapeutics, Inc. Detection of autoantibodies against nr1
WO2026033259A1 (en) * 2024-08-05 2026-02-12 Lys Therapeutics Antibodies for treating neurological and neurovascular disorders
WO2026044177A1 (en) * 2024-08-23 2026-02-26 Janssen Biotech, Inc. Methods of treatment with gprc5d antibodies with enhanced effector function

Citations (2)

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WO2014187879A2 (en) 2013-05-21 2014-11-27 Paion Deutschland Gmbh Novel antibody useful in neurological or neurodegenerative disorders
WO2017029299A1 (en) 2015-08-17 2017-02-23 Deutsches Zentrum Für Neurodegenerative Erkrankungen E.V. (Dzne) Antibody or antibody fragment or non-ig scaffold binding to a binding region of an anti-n-methyl-d-aspartate (nmda) receptor antibody

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US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
IL162181A (en) 1988-12-28 2006-04-10 Pdl Biopharma Inc A method of producing humanized immunoglubulin, and polynucleotides encoding the same
ATE299938T1 (de) 1997-05-02 2005-08-15 Genentech Inc Ein verfahren zur herstellung multispezifischer antikörper die heteromultimere und gemeinsame komponenten besitzen
PT1718677E (pt) * 2003-12-19 2012-07-18 Genentech Inc Fragmentos de anticorpo monovalentes úteis como agentes terapêuticos
WO2019246071A1 (en) 2018-06-18 2019-12-26 Denali Therapeutics Inc. Fusion proteins comprising progranulin
WO2020204977A1 (en) 2019-03-29 2020-10-08 Lankenau Institute For Medical Research Anti-nmda receptor antibodies and methods of use
EP3999850A1 (en) 2019-07-16 2022-05-25 Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. (DZNE) Nmda receptor constructs to detect and isolate nmdar autoantibodies
WO2021241616A1 (ja) 2020-05-27 2021-12-02 アステラス製薬株式会社 抗ヒトｎｒ１抗体誘導体
CN114891091B (zh) 2022-06-13 2024-04-26 四川携光生物技术有限公司 一种抗nmdar脑炎重组抗原及应用
AU2024242885A1 (en) 2023-03-30 2025-09-11 Arialys Therapeutics, Inc. Detection of autoantibodies against nr1

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Publication number Priority date Publication date Assignee Title
WO2014187879A2 (en) 2013-05-21 2014-11-27 Paion Deutschland Gmbh Novel antibody useful in neurological or neurodegenerative disorders
WO2017029299A1 (en) 2015-08-17 2017-02-23 Deutsches Zentrum Für Neurodegenerative Erkrankungen E.V. (Dzne) Antibody or antibody fragment or non-ig scaffold binding to a binding region of an anti-n-methyl-d-aspartate (nmda) receptor antibody

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[Experimental Neurology (Exp. Neurol.)], (USA), 2017; 289: 31-45
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[Journal of Neuroscience, (J. Neurosci.)], (USA), 2010; 30(17): 5866-5875
[Science (Science)], (USA), 2016; 352 (6288): 982-986

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US20230220070A1 (en) 2023-07-13
CN116133684A (zh) 2023-05-16
BR112022023931A2 (pt) 2023-04-11
AU2021281828A1 (en) 2023-02-02
CN120737200A (zh) 2025-10-03
JPWO2021241616A1 (https=) 2021-12-02
CN116133684B (zh) 2025-07-18
CA3180470A1 (en) 2021-12-02
WO2021241616A1 (ja) 2021-12-02
IL298537A (en) 2023-01-01
MX2022014856A (es) 2023-03-06
EP4159859A1 (en) 2023-04-05
US20250122281A1 (en) 2025-04-17
EP4159859A4 (en) 2024-07-10
US12331113B2 (en) 2025-06-17

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