KR20230026492A - Pd-1 길항제, hif-2 알파 억제제 및 렌바티닙 또는 그의 제약상 허용되는 염의 조합물을 사용하여 암 또는 폰-히펠 린다우병을 치료하는 방법 - Google Patents

Pd-1 길항제, hif-2 알파 억제제 및 렌바티닙 또는 그의 제약상 허용되는 염의 조합물을 사용하여 암 또는 폰-히펠 린다우병을 치료하는 방법 Download PDF

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KR20230026492A
KR20230026492A KR1020237002564A KR20237002564A KR20230026492A KR 20230026492 A KR20230026492 A KR 20230026492A KR 1020237002564 A KR1020237002564 A KR 1020237002564A KR 20237002564 A KR20237002564 A KR 20237002564A KR 20230026492 A KR20230026492 A KR 20230026492A
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human
cancer
rcc
lenvatinib
administered
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Korean (ko)
Inventor
로돌포 플뢰리 페리니
일레인 엠. 피네이루
자클린 빌레만 로게리오
Original Assignee
머크 샤프 앤드 돔 엘엘씨
에자이 알앤드디 매니지먼트 가부시키가이샤
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Priority claimed from PCT/US2021/038171 external-priority patent/WO2021262562A2/en
Publication of KR20230026492A publication Critical patent/KR20230026492A/ko
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A—HUMAN NECESSITIES
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    • A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2857—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, orphan receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered

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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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KR1020237002564A 2020-06-22 2021-06-21 Pd-1 길항제, hif-2 알파 억제제 및 렌바티닙 또는 그의 제약상 허용되는 염의 조합물을 사용하여 암 또는 폰-히펠 린다우병을 치료하는 방법 Pending KR20230026492A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063042225P 2020-06-22 2020-06-22
US63/042,225 2020-06-22
US202163146926P 2021-02-08 2021-02-08
US63/146,926 2021-02-08
PCT/US2021/038171 WO2021262562A2 (en) 2020-06-17 2021-06-21 Methods for treating cancer or von-hippel lindau disease using a combination of a pd-1 antagonist, a hif-2 alpha inhibitor, and lenvatinib or a pharmaceutically acceptable salt thereof

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Publication Number Publication Date
KR20230026492A true KR20230026492A (ko) 2023-02-24

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KR1020237002564A Pending KR20230026492A (ko) 2020-06-22 2021-06-21 Pd-1 길항제, hif-2 알파 억제제 및 렌바티닙 또는 그의 제약상 허용되는 염의 조합물을 사용하여 암 또는 폰-히펠 린다우병을 치료하는 방법

Country Status (7)

Country Link
US (1) US20230250182A1 (https=)
EP (1) EP4168016A4 (https=)
JP (2) JP7699613B2 (https=)
KR (1) KR20230026492A (https=)
BR (1) BR112022026086A2 (https=)
CA (1) CA3183862A1 (https=)
MX (2) MX2022016410A (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116063211B (zh) * 2023-02-14 2023-11-10 斯坦德药典标准物质研发(湖北)有限公司 一种Belzutifan的制备方法
WO2025235493A1 (en) * 2024-05-07 2025-11-13 Arcus Biosciences, Inc. Casdatifan for use in the treatment of cancer

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5595756A (en) * 1993-12-22 1997-01-21 Inex Pharmaceuticals Corporation Liposomal compositions for enhanced retention of bioactive agents

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JP2023531930A (ja) 2023-07-26
JP2025156341A (ja) 2025-10-14
US20230250182A1 (en) 2023-08-10
EP4168016A4 (en) 2024-08-07
MX2022016410A (es) 2023-04-05
JP7699613B2 (ja) 2025-06-27
BR112022026086A2 (pt) 2023-03-07
CA3183862A1 (en) 2021-12-30
EP4168016A2 (en) 2023-04-26
MX2025014866A (es) 2026-01-07

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