KR20220168294A - Whitening cosmetics containing plant extracts as valid ingredients - Google Patents

Abstract

The present invention relates to a cosmetic for whitening containing plant extracts as active ingredients, comprising: a cosmetic composition containing plant extracts from Chrysanthemum indicum Linne, Cornus macrophylla Wallich, and Broussonetia kazinoki var. humilis as active ingredients. The cosmetic composition has an excellent whitening effect by suppressing the activity of tyrosinase by having any one formulation selected from the group consisting of skin lotion, skin softener, skin toner, astringent, lotion, milk lotion, moisture lotion, nutrient lotion, massage cream, nutrient cream, moisture cream, hand cream, foundation, essence, nutrient essence, pack, soap, cleansing foam, cleansing lotion, cleansing cream, body lotion and body cleanser.

Description

Whitening cosmetics containing plant extracts as valid ingredients}

The present invention relates to a cosmetic for whitening and a method for manufacturing the same, and more particularly, to melanin by containing a plant extract.

In cosmetics for whitening and their manufacturing method, which prevent and improve pigmentation such as red spots and freckles by suppressing the generation of

it's about

Pigmentation such as red spots and freckles on the skin is caused by hormonal abnormalities, ultraviolet rays, and local inflammation of the skin, and melanin

It is thought that melanin is excessively formed and deposited in the skin. Causes of skin pigmentation

This melanin, which becomes, is called melanosome in pigment cells (melanocytes) in the basal layer of the epidermis.

It is produced in organelles called melanin, and the produced melanin is taken up by surrounding keratinocytes (keratinocytes).

Melanin in these melanocytes is induced by tyrosine by the action of the enzyme tyrosinase.

It is produced by being converted into black melanin by an enzymatic or non-enzymatic oxidation reaction through quinone. follow

Therefore, inhibiting the activity of tyrosinase, which is the first step reaction, inhibits the production of melanin.

It is important.

For the purpose of preventing and improving the above pigment abnormalities, substances having a whitening effect, that is, substances suppressing melanin production, are mainly used. For example, a method of orally administering a large amount of vitamin C, glutathione,

How to inject, or ointment, cream, lotion, etc.

A method of applying topically in the form of the like, etc. is known.

However, compounds that inhibit the activity of tyrosinase, except for hydroquinone, exhibit very modest effects.

Therefore, the effect of improving skin pigmentation is not sufficient. On the other hand, although the effect of hydroquinone is recognized, it is sensitizing.

Because of this, its general use is limited. So, in order to improve its safety, monoesters of higher fatty acids

Attempts are being made to use le (monoester) or alkyl monoester (alkyl monoester).

However, since these monoesters of higher fatty acids are decomposed by hydrolytic enzymes in the body, they are necessarily safe.

It is difficult to say that it is, and ethers are not sufficiently satisfactory in terms of safety.

Therefore, the present inventors investigated the melanin production inhibitory effect with respect to various plant extracts, and thus far, these

For a specific plant extract that was not known to have an effect, melanin production inhibitory action and tyrosinase

It was found that it had an inhibitory effect, and the present invention was completed.

Therefore, the present invention has been made to solve the above problems of the prior art, the object of the present invention is Tyrosina

It has excellent skin aging prevention and skin whitening effect by suppressing the activity of azeotropin and inhibiting melanin production, and stability

It is to provide a cosmetic for whitening containing a plant extract that does not have a problem and a manufacturing method thereof.

Cosmetics for whitening containing the plant extract of the present invention for achieving the above object are

It includes a cosmetic composition containing a plant extract from the mulberry tree as an active ingredient, the cosmetic composition comprising a skin

lotion, skin softener, skin toner, astringent, lotion, milk lotion, moisture lotion, nutrition lotion, massage cream, nutrition cream,

Moisture cream, hand cream, foundation, essence, nutrition essence, pack, soap, cleansing foam, cleansing lotion, cleansing cream, body

It is characterized by having any one formulation selected from the group consisting of lotion and body cleanser.

On the other hand, the method for manufacturing cosmetics for whitening containing the plant extract of the present invention is a formula from gamguk, bear's horseradish, and mulberry tree.

Preparing a composition containing the water extract as an active ingredient; And adding the composition to the aqueous phase or oil phase

It is characterized by including a system.

As described above, according to the cosmetic for whitening and the manufacturing method according to the present invention, it has melanin production inhibitory action.

It has an excellent effect on pigmentation after sunburn, lightening of red spots, freckles, melasma, etc., and whitening.

It is possible to provide a whitening cosmetic having excellent safety.

Hereinafter, the whitening cosmetic of the present invention will be described in detail with reference to the accompanying drawings.

Singular terms used in the present invention are plural, except when it is clear that they are singular from the relationship between the front and back.

do it with

The whitening cosmetic of the present invention is a plant of the Moraceae family, Broussonetia kazinokivar. humilis, and a plant of the Dogwood family.

Including plant extracts of bear's horsetail (Corus macrophylla) and Chrysanthemumindicum (Asteraceae),

gets ripped

Broussonetia kazinokivar. humilis of the Moraceae plant used in the external preparation for whitening according to the present invention;

Corus macrophylla of the Dogwood family and Chrysanthemumindicum of the Asteraceae plant are found in Korea, Taiwan,

It is a plant that grows in China and Japan.

Broussonetia kazinokivar. humilis, a member of the Moraceae family, is called a semi-liquid and is used for diuretics.

it is known

Bear's horsetail (Corus macrophylla) of the Dogwood family plant is used to treat cold fever, cholera, acute gastroenteritis, dysentery, and pain in cardiac arrest.

It is known to be used for the like.

Chrysanthemumindicum, a plant of the Asteraceae family, is called salcachemican and is used for cold, hematemesis, cough, gastric pain, and rheumatism.

It is known to be used for wounds and pain.

The plant extract used in the present invention is extracted from the leaves of the plant, stems including underground stems, roots, fruits, plant outposts, etc.

It is obtained by immersion or heating to reflux together with an extraction solvent, followed by filtration and concentration. The extraction solvent used in the present invention is

Any solvent used for phase extraction is suitable, especially alcohols such as methanol and ethanol, hydrous alcohols, acetone, and acetic acid.

Organic solvents, such as tyl ester, can be used individually or in combination.

The blending amount of the plant extract in the cosmetic for whitening of the present invention is 0.001 to 20.0 as a dry matter in the total amount of the external preparation.

% by mass, preferably 0.01 to 10.0% by mass. If it is less than 0.001% by mass, the effect referred to in the present invention tends to be insufficient.

However, when it exceeds 20.0% by mass, it is not preferable because formulation is difficult. In addition, blending beyond 10.0% by mass

However, it is not possible to see a significant improvement in the effect.

In the cosmetic for whitening of the present invention, in addition to the above essential ingredients, ingredients commonly used in cosmetics such as cosmetics and pharmaceuticals,

For example, other whitening agents, moisturizing agents, antioxidants, oily ingredients, ultraviolet absorbers, surfactants, thickeners, alcohols, powdery

Base components such as powder, coloring material, aqueous components, water, and various skin nutrients can be appropriately blended as needed.

Others, gold such as disodium edetate, trisodium edetate, sodium citrate, sodium polyphosphate, sodium metaphosphate, and gluconic acid

Blocking agents, caffeine, tannins, verapamil, tranexamic acid and its derivatives, licorice extract, glabridin, paracantha (firethorn)

Hot water extracts of fruits, various herbal medicines, drugs such as tocopherol acetate, glycyrrhizic acid and its derivatives or salts, vitamin C,

Others such as magnesium ascorbate phosphate, ascorbic acid glucoside, arbutin, kojic acid, lucinol, ellagic acid, chamomile, etc.

Sugars such as whitening agents, glucose, fructose, mannose, sucrose, and torehalose can also be appropriately blended.

Cosmetics for whitening of the present invention include, for example, ointments, creams, emulsions, lotions, packs, bath preparations, etc. conventionally used in external skin preparations.

Any one may be used, and the formulation is not particularly limited.

The whitening cosmetics of the present invention include water-soluble vitamins, oil-soluble vitamins, high-molecular peptides, high-molecular polysaccharides, sphingolipids, and seaweed.

It may further include a component selected from the group consisting of extracts.

Any water-soluble vitamin can be used as long as it can be incorporated into cosmetics, but preferably vitamin B1 and vitamin B1.

Min B2, Vitamin B6, Pyridoxine, Pyridoxine Hydrochloride, Vitamin B12, Pantothenic Acid, Nicotinic Acid, Nicotinic Acid Amide, Folic Acid, Vitamin C,

vitamin H, etc., and their salts (thiamine hydrochloride, sodium ascorbate, etc.) or derivatives (ascorbic acid-

2-phosphate sodium salt, ascorbic acid-2-phosphate magnesium salt, etc.) are also included in the water-soluble vitamins that can be used in the present invention.

Water-soluble vitamins are obtained by conventional methods such as microbial transformation, purification from microbial cultures, enzymatic methods, or chemical synthesis methods.

can be obtained by

Any useful vitamin may be used as long as it can be incorporated into cosmetics, but preferably vitamin A or caro

tin, vitamin D2, vitamin D3, vitamin E (d1-α tocopherol, d-α tocopherol, d-δ tocopherol), etc.

Derivatives (ascorbine palmitate, ascorbine stearate, ascorbine dipalmitate, dl-α tocopherol acetate, nicotinic acid

dl-α tocopherol vitamin E, DL-pantothenyl alcohol, D-pantothenyl alcohol, pantothenyl ethyl ether, etc.) are also included in the useful vitamins used in the present invention. Useful vitamins are obtained by microbial transformation, purification from microbial cultures, enzymes or

It can be obtained by conventional methods such as chemical synthesis.

Any polymer peptide can be used as long as it can be incorporated into cosmetics, but collagen and hydrolysis are preferred.

Collagen, gelatin, elastin, hydrolyzed elastin, keratin, etc. are mentioned. High-molecular peptides are used as a culture medium of microorganisms.

It can be purified and obtained by a conventional method such as a purification method, an enzyme method, or a chemical synthesis method from

It can be used after being purified from natural products such as the dermis of cows and silk fibers of silkworms.

Any polymeric polysaccharide can be used as long as it can be incorporated into cosmetics, but hydroxyethyl cellulose is preferred.

lozenges, xanthan gum, sodium hyaluronate, chondroitin sulfate or salts thereof (sodium salt, etc.); and the like. for example,

Chondroitin sulfate or a salt thereof can be used after being purified from a mammal or fish.

Any sphingolipid can be used as long as it can be formulated into cosmetics, but ceramide and phytosphing are preferred.

Kosin, sphingoglycolipid, etc. are mentioned. Sphingolipids are commonly found in mammals, fish, shellfish, yeast or plants.

It can be purified by the above method or obtained by chemical synthesis.

Any seaweed extract can be used as long as it can be formulated into cosmetics, but brown algae extract and red algae extract are preferred.

algae extract, algae extract, and the like, and also calrageenan, arginic acid, and arginic acid purified from these seaweed extracts.

Tritium, potassium alginate, etc. are also included in the seaweed extract used in the present invention. The seaweed extract is normal from seaweed

It can be obtained by purification by law.

The external preparation for whitening of the present invention may contain other ingredients commonly used in cosmetics, if necessary. Even if added in addition to

As the ingredients to be formulated, oils and fats, moisturizing agents, emollients, surfactants, organic and inorganic pigments, organic powders, ultraviolet

Preservatives, bactericides, antioxidants, plant extracts, pH adjusters, alcohols, pigments, fragrances, blood circulation promoters, cooling agents,

An antiperspirant, purified water, etc. are mentioned.

Examples of oils and fats include ester oils, hydrocarbon oils, silicone oils, fluorine oils, animal fats and vegetable oils, etc.

can be heard

Examples of ester oils include glyceryl tri-2-ethylhexanoate, cetyl 2-ethylhexanoate, isopropyl myristate, butyl myristate,

Isopropyl palmitate, ethyl stearate, octyl palmitate, isocetyl isostearate, butyl stearate, ethyl linoleate,

Isopropyl linoleate, ethyl oleate, isocetyl myristate, isostearyl myristate, isostearyl palmitate, myristate

Octyldodecyl stannate, isocetyl isostearate, diethyl sebacate, diisopropyl adipate, isoalkyl neopentanoate, tri

(capryl, capric acid) glyceryl, trimethylolpropane tri2-ethylhexanoate, trimethylolpropane triisostearate, tetra

2-Ethylhexanoate pentaelislitol, cetyl caprylate, decyl laurate, hexyl laurate, decyl myristate,

Myristyl myristate, cetyl myristate, stearyl stearate, decyl oleate, cetyl ricinooleate, isose laurate

Tearyl, isotridecyl myristate, isocetyl palmitate, octyl stearate, isocetyl stearate, isodecyl oleate,

Octyldodecyl oleate, octyldodecyl linoleate, isopropyl isostearate, cetostearyl 2-ethylhexanoate, 2-ethylhexanoic acid

Stearyl, hexyl isostearate, ethylene glycol dioctanoate, ethylene glycol dioleate, propylene glycol dicaprate,

(Caprylic, capric acid) propylene glycol, dicaprylic acid propylene glycol, dicapric acid neopentyl glycol, dioctanoic acid neopentyl glycol

Recall, glyceryl tricaprylate, glyceryl triundecylate, glyceryl triisopalmitate, glyceryl triisostearate,

Octyldodecyl neopentanoate, isostearyl octanoate, octyl isononanoate, hexyldecyl neodecanoate, octyldodecyl neodecanoate, iso

Isocetyl stearate, isostearyl isostearate, octyldecyl isostearate, polyglycerin oleate, poly

Liglycerin isostearate, triisocetyl citrate, triisoalkyl citrate, triisooctyl citrate, lactate

Acid lauryl, myristyl lactate, cetyl lactate, octyldecyl lactate, triethyl citrate, acetyl triethyl citrate, citric acid

Acetyltributyl, trioctyl citrate, diisostearyl malate, 2-ethylhexyl hydroxystearate, di2-ethylhexyl succinate,

Diisobutyl adipate, diisopropyl sebacate, dioctyl sebacate, cholesteryl stearate,

cholesteryl isostearate, cholesteryl hydroxystearate, cholesteryl oleate, dihydrocholesteryl oleate,

Physteryl isostearate, Physteryl oleate, 12-stealoylhydroxystearate isocetyl, 12-stealoylhydro

and esters such as stearyl oxystearate and isostearyl 12-stealoylhydroxystearate.

Examples of hydrocarbon-based fats and oils include squalene, liquid paraffin, α-olefin oligomer, isoparaffin, ceresin, paraffin, and liquid isofa.

and hydrocarbon-based fats and oils such as laffin, polybuden, microcrystalline wax, and vaseline.

Examples of silicone oils include polymethylsilicone, methylphenylsilicone, methylcyclopolysiloxane, octamethylpolysiloxane, and decamethylpole.

lysiloxane, dodecamethylcyclosiloxane, dimethylsiloxane/methylcetyloxysiloxane copolymer, dimethylsiloxane/methylstealoxysiloxane copolymer, alkyl-modified silicone oil, amino-modified silicone oil, and the like. As fluorine-based fats and oils, perfluoro

Polyether etc. are mentioned.

Animal or vegetable oils include avocado oil, almond oil, olive oil, sesame oil, rice bran oil, bird flower oil, soybean oil,

Corn Oil, Rapeseed Oil, Almond Oil, Palm Kernel Oil, Palm Oil, Castor Oil, Sunflower Oil, Grapeseed Oil, Cottonseed Oil, Palm Oil, Cuckooiner

Tofu oil, wheat germ oil, rice germ oil, shea butter, moonshine colostrum, marker daemia nut oil, meadow hump oil, egg yolk oil, beef tallow, horse oil,

Animal or food products such as mink oil, orange rapier oil, jojoba oil, candelilla wax, carnaba wax, liquid lanolin, hydrogenated castor oil, etc.

water retention can be cited.

Examples of the moisturizer include water-soluble low-molecular moisturizers, fat-soluble molecular moisturizers, water-soluble polymers, and oil-soluble polymers.

Examples of water-soluble low-molecular moisturizers include serine, glutamine, sorbitol, mannitol, pyrrolidone-sodium carboxylate, glycerin, and propylene.

Glycol, 1,3-butylene glycol, ethylene glycol, polyethylene glycol (degree of polymerization n = 2 or more), polypropylene glycol (degree of polymerization n

= 2 or more), polyglycerol (polymerization degree n = 2 or more), lactic acid, lactate, and the like.

Cholesterol, cholesterol ester, etc. are mentioned as a fat-soluble low-molecular moisturizer.

Examples of water-soluble polymers include carboxyvinyl polymer, polyaspartic acid, tragacanth, xanthan gum, methyl cellulose, and hydrochloric acid.

Cymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, carboxymethyl cellulose, water-soluble chitin,

Chitosan, dextrin, etc. are mentioned.

As fat-soluble polymers, polyvinylpyrrolidone-eicosene copolymer, polyvinylpyrrolidone-hexadecene copolymer, nitrocellulose

lozenges, dextrin fatty acid esters, polymeric silicones, and the like.

As the emollient agent, long-chain acyl glutamic acid cholesteryl ester, hydroxystearate cholesteryl, 12-hydroxystea

lactic acid, stearic acid, rosin acid, lanolin fatty acid cholesteryl ester, and the like.

Examples of surfactants include nonionic surfactants, anionic surfactants, cationic surfactants, and amphoteric surfactants.

can be heard

Nonionic surfactants include self-emulsifying glycerin monostearate, propylene glycol fatty acid esters, and glycerin paper.

Radiation esters, polyglycerin fatty acid esters, sorbitan fatty acid esters, POE (polyoxyethylene) sorbitan fatty acid esters,

POE Sorbit Fatty Acid Esters, POE Glycerin Fatty Acid Esters, POE Alkyl Ethers, POE Fatty Acid Esters, POE Hardened Castor

Oil, POE castor oil, POE/POP (polyoxyethylene/polyoxypropylene) copolymer, POE/POP alkyl ether, polyether

modified silicones, lauric acid alkanolamides, alkylamine oxides, hydrogenated soybean phospholipids, and the like.

Examples of anionic surfactants include fatty acid soaps, α-acyl sulfonates, alkyl sulfonates, alkyl allyl sulfonates, and alkyl naphthalene sulfones.

acid salts, alkyl sulfates, POE alkyl ether sulfates, alkylamide sulfates, alkyl phosphates, POE alkyl phosphates, alkyl amide phosphates,

Alkyloylalkyl taurine salt, N-acylamino acid salt, POE alkyl ether carboxylate, alkyl sulfosuccinate, alkyl sulfoacetic acid or

tritium, acylated hydrolyzed collagen peptide salts, perfluoroalkyl phosphate esters, and the like.

Examples of the cationic surfactant include alkyltrimethylammonium chloride, stearyltrimethylammonium chloride, and stearyltrimethylammonium bromide.

Ammonium, cetostearyltrimethylammonium chloride, distearyldimethylammonium chloride, stearyldimethylbenzylammonium chloride, behe bromide

Nyltrimethylammonium, benzalkonium chloride, diethylaminoethyl stearate, dimethylaminopropylamide stearate, la

quaternary ammonium salts of Nolin derivatives; and the like.

Amphoteric surfactants include carboxybetaine type, amidebetaine type, sulfobetaine type, hydroxysulfobetaine type, and amide sulfone type.

Amphoteric surfactants such as betaine type, phosphobetaine type, aminocarboxylate type, imidazoline derivative type, amideamine type, etc.

etc. can be mentioned.

As organic and inorganic pigments, silicic acid, silicic anhydride, magnesium silicate, talc, sericite, mica, kaolin, bengala, clay,

Bentonite, titanium-coated mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide, titanium oxide,

Aluminum oxide, calcium sulfate, barium sulfate, magnesium sulfate, calcium carbonate, magnesium carbonate, iron oxide, ultramarine blue, chromium oxide, chromium oxide

inorganic pigments such as chromium, calamine and complexes thereof; Polyamide, polyester, polypropylene, polystyrene, polyurethane

Carbon, vinyl resin, urea resin, phenolic resin, fluorine resin, silicon resin, acrylic resin, melamine resin, epoxy resin, polycarbonate

Oils such as resin, divinylbenzene styrene copolymer, silk powder, cellulose, CI pigment yellow, CI pigment orange, etc.

Group pigments and composite pigments of these inorganic pigments and organic pigments, and the like are exemplified.

Examples of the organic powder include metal soaps such as calcium stearate; sodium cetylate,

<51> metal salts of alkyl phosphates such as zinc laurylate and calcium laurylate; Acylas such as N-lauroyl-β-alanine calcium, N-lauroyl-β-alanine zinc, N-lauroylglycine calcium, etc.

polyvalent metal salts of mino acids; polyvalent metal salts of amide sulfonic acids such as N-lauroyl-taurine calcium and N-palmitoyl-taurine calcium; Nε-Lauro

Il-L-lysine, Nε-palmitoylizine, Nα-paritoylolnithine, Nα-lauroylarginine, Nα-hardened beef tallow fatty acid acylarginine, etc.

of N-acyl basic amino acids; N-acyl polypeptides such as N-lauroylglycylglycine; α-aminocaprylic acid, α-aminolau

α-amino fatty acids such as phosphoric acid; Polyethylene, polypropylene, nylon, polymethyl methacrylate, polystyrene, divinyl

A benzene styrene copolymer, ethylene tetrafluoride, etc. are mentioned.

Examples of the ultraviolet absorber include para-aminobenzoic acid, ethyl para-aminobenzoate, amyl para-aminobenzoate, octyl para-aminobenzoate,

Ethylene glycol salicylate, phenyl salicylate, octyl salicylate, benzyl salicylate, butylphenyl salicylate, homomenthyl salicylate, cinnamon

Benzyl acid, paramethoxycinnamic acid-2-ethoxyethyl, paramethoxycinnamic acid octyl, diparamethoxycinnamic acid mono-2-ethylhexane glyceryl,

Isopropyl para-methoxycinnamic acid, diisopropyl/diisopropyl cinnamic acid ester mixture, urocanic acid, ethyl urocanic acid,

Hydroxymethoxybenzophenone, hydroxymethoxybenzophenonesulfonic acid and its salts, dihydroxymethoxybenzophenone, dihydroxymethoxy

Sodium cybenzophenone disulfonate, dihydroxybenzophenone, tetrahydroxybenzophenone, 4-tert-butyl-4'-methoxydibenzoylmethane,

2,4,6-trianilino-p-(carbo-2'-ethylhexyl-1'-oxy)-1,3,5-triazine, 2-(2-hydroxy-5-methylphenyl)benzo triazole

etc. can be mentioned.

As disinfectants, hinokitiol, triclosan, trichlorohydroxydiphenyl ether, chlorhexidine gluconate, phenoxyethane

Ol, resorcin, isopropylmethylphenol, azulene, salicylic acid, zinc phyllithione, benzalkonium chloride, photoreceptor No. 301, mononit

Roguaycol sodium, undecyrenic acid, etc. are mentioned.

Examples of antioxidants include butylhydroxyanisole, propyl gallic acid, and elisorbic acid.

Examples of the pH adjuster include citric acid, sodium citrate, malic acid, sodium malate, fumaric acid, sodium fumalate, succinic acid, sodium succinate,

Sodium hydroxide, sodium monohydrogenphosphate, etc. are mentioned.

Examples of alcohol include higher alcohols such as cetyl alcohol. In addition, other ingredients that may be added are limited to these.

It is not, and any of the above components can be formulated within a range that does not impair the objects and effects of the present invention,

It is blended preferably in an amount of 0.001 to 20.0% by mass, more preferably 0.01 to 10.0% by mass, based on the total weight.

Cosmetics for whitening according to the present invention may take the form of solutions, emulsions, viscous mixtures, and the like.

Ingredients included in the cosmetic for whitening according to the present invention are active ingredients, in addition to the extract or compound, cosmetic composition

It may contain components commonly used in water, such as stabilizers, solubilizers, vitamins, pigments and flavors.

It includes conventional adjuvants and carriers such as

Cosmetics for whitening according to the present invention may be prepared in any formulation commonly manufactured in the art, for example

For example, emulsions, creams, toners, packs, foundations, lotions, serums, hair cosmetics, and the like. Specifically, the present invention

Cosmetic compositions include skin lotion, skin softener, skin toner, astringent, lotion, milk lotion, moisture lotion, nutrient lotion,

Massage Cream, Nutrition Cream, Moisture Cream, Hand Cream, Foundation, Essence, Nutrition Essence, Pack, Soap, Cleansing Foam, Cleansing

It includes formulations of lotion, cleansing cream, body lotion and body cleanser.

When the formulation of the present invention is a paste, cream or gel, animal fibers, vegetable fibers, waxes, paraffins,

powder, tracanth, cellulose derivatives, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide.

can be used

When the formulation of the present invention is a powder or spray, lactose, talc, silica, aluminum hydroxy as a carrier component

powder, calcium silicate or polyamide powder may be used, especially in the case of a spray, additionally chloro

propellants such as fluorohydrocarbons, propane/butane or dimethyl ether.

In the case where the formulation of the present invention is a solution or emulsion, a solvent, solvating agent or emulsifying agent is used as a carrier component, e.g.

For example, water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene

Fatty acid esters of glycol, 1,3-butyl glycol oil, glycerol fatty esters, polyethylene glycol or sorbitan

there is

When the formulation of the present invention is a suspension, as a carrier component, a liquid diluent such as water, ethanol or propylene glycol;

such as ethoxylated isostearyl alcohols, polyoxyethylene sorbitol esters and polyoxyethylene sorbitan esters.

Silver suspending agents, microcrystalline cellulose, aluminum metahydroxide, bentonite, agar or tracanth and the like may be used.

When the formulation of the present invention is a surfactant-containing cleanser, aliphatic alcohol sulfate, aliphatic alcohol as a carrier component

All ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, methyl taurate, sarco

Sinates, fatty acid amide ether sulfates, alkylamidobetaines, fatty alcohols, fatty acid glycerides, fatty acid die

Tanoamide, vegetable oil, linolin derivative, or ethoxylated glycerol fatty acid ester may be used.

Hereinafter, the present invention will be described in more detail through examples. On the other hand, the present invention is limited by this

no. A compounding quantity is mass %. Prior to the examples, melanin production inhibitory effect and whitening effect of the plant extract of the present invention

The test method and its results are explained.

Test methods and results

1. Sample preparation

(1) Extract of Broussonetia kazinokivar. humilis

Broussonetia kazinokivar. 60 g of humilis outpost was immersed in methanol for one week at room temperature, the extract was filtered,

The solvent was distilled off to obtain 1.6 g of methanol extract. This extract was dissolved in DMSO at 1% by mass, and this solution was diluted to obtain a concentration

After adjusting, the following experiment was conducted using this.

(2) Bear's horsetail (Corus macrophylla) extract

31 g of the root and subterranean stem part of Corus macrophylla was immersed in methanol for one week at room temperature, the extract was filtered,

The solvent was distilled off to obtain 1.6 g of methanol extract. This extract was dissolved in DMSO at 1% by mass, and this solution was diluted to a concentration

was adjusted, and the following experiments were conducted using this.

(3) Chrysanthemumindicum extract

30 g of the root part of Chrysanthemumindicum was immersed in methanol for one week at room temperature, the extract was filtered, and the solvent was evaporated.

This gave 1.4 g of methanol extract. 1% by mass of this extract was dissolved in DMSO, and the concentration was adjusted by diluting this solution.

And, using this, the following experiments were conducted.

2. Cell culture method

Mouse B 16 melanoma cultured cells were used. in Eagle MEM medium containing 10% FBS and theophylline (0.09 mg/ml)

In a CO2 incubator (95% air, 5% carbon dioxide), they were cultured under conditions of 37°C. For samples after 24 hours of incubation

The liquid was added so that the final concentration (concentration in terms of extracted dry matter) was 2 × 10 -3 to 10 -5% by weight, and culture was continued for 3 days,

Visibility determination of the amount of melanin production was measured by the following method.

3. Visual measurement of melanin amount

Place a diffusion plate on the cover of the plate and observe the number of cells and the amount of melanin in the cells with an inverted microscope.

kazinokivar. For the sample (standard) to which extracts of humilis, Corus macrophylla, and Chrysanthemumindicum were not added,

compared to wow. The results are shown in Table 1. Also, as a reference example, it has already been known to have melanin production inhibitory action.

The same test as above was also conducted for arbutin. The results are shown in Table 1 together. Regarding cell proliferation

was the result of "no inhibition" in all samples tested.

As a criterion, ○ means that little melanin is produced and is white, and △ means that a small amount of melanin is produced.

It means a little bit white,

× means that the amount of melanin is produced by a predetermined reference amount.

Although the present invention has been described in more detail with several examples above, the present invention is necessarily limited to these examples.

It is not limited and can be variously modified and implemented without departing from the spirit of the present invention.

Claims (4)

A cosmetic composition containing plant extracts from chrysanthemum chrysanthemum, bear's horseradish, and mulberry mulberry as an active ingredient,
The cosmetic composition is skin lotion, skin softener, skin toner, astringent, lotion, milk lotion, moisture lotion, and nutrition.
lotion, massage cream, nutrition cream, moisture cream, hand cream, foundation, essence, nutrition essence, pack, soap, cleansing foam, cleanser
A plant having any formulation selected from the group consisting of lenzing lotion, cleansing cream, body lotion and body cleanser
Cosmetics for whitening containing extracts. According to claim 1,
The cosmetic composition,
Characterized in that it is included in 0.001 to 20.0 mass% as dry weight relative to the total weight of the whitening cosmetic
A cosmetic for whitening containing plant extracts. A whitening method characterized in that skin whitening is performed using the whitening cosmetic according to claim 1. preparing a composition containing plant extracts from gamguk, bear's horseradish, and mulberry mulberry as an active ingredient; and
adding the composition to an aqueous or oil phase;
A method for manufacturing cosmetics for whitening comprising a.