KR20220168041A - Skin external application composition for improving seborrheic dematitis - Google Patents

Abstract

The present invention relates to a skin external application composition for alleviating seborrheic dermatitis which contains an Aletris spicata extract as an active ingredient, and more specifically, to a skin external application composition for alleviating seborrheic dermatitis which prevents seborrheic dermatitis and which does not cause side effects even when used for a long time. 0.001 to 10 wt% of the Aletris spicata extract is included based on the total weight of the composition.

Description

Skin external application composition for improving seborrheic dermatitis {Skin external application composition for improving seborrheic dematitis}

The present invention relates to a composition for improving seborrheic dermatitis containing an extract of rattail as an active ingredient.

Skin sebaceous glands are fully secreted glands that secrete a mixture of lipids known as sebum. The term "sebum" refers to the secretion of the sebaceous glands containing triglycerides, free fatty acids, wax esters, squalene, cholesterol and cholesteryl esters. Excessive production of sebum in the sebaceous glands results in oily skin and can also contribute to the development of other skin disorders, diseases or conditions, such as acne and seborrheic dermatitis. Sebum production is regulated by factors that affect the proliferation and differentiation of sebaceous gland cells, and factors such as male hormones, female hormones, IGF-1 (insulin-like growth factor), and PPAR (peroxisome proliferator activated receptor) are involved in sebum production. known to be related to Sebum produced by sebaceous gland cells is secreted to the skin surface through the hair follicle duct, and the produced sebum is known to degrade the skin barrier function by changing the structure of lipids between keratinocytes on the skin surface. Overgrowth of seborrheic scalpitis bacteria is known to be the cause of seborrheic dermatitis and scalp inflammation. Therefore, proper removal of the produced sebum and suppression of sebum production are considered important for maintaining the skin barrier function and healthy skin.

As a method for suppressing sebum production, a substance that inhibits 5α-reductase, which functions to convert testosterone, a male hormone, into dihydrotestosterone, has been developed and used. In addition, efforts are being made to inhibit sebum production by transdermal application of an androgen receptor inhibitor that inhibits the binding of testosterone and dihydrotestosterone to the receptor. However, these hormone inhibitors have difficulties in transdermal delivery, and even if they are effectively delivered by transdermal administration, there is a possibility that they may affect the balance of hormones throughout the body, so development is not easy.

On the other hand, seborrheic dermatitis is a very common disease that occurs in 3 out of 10 people, and symptoms often occur not only on the face but also on the scalp.

An object of the present invention is to provide a composition for external application for skin that can improve seborrheic dermatitis composed of natural substances harmless to the human body.

In order to achieve the object of the present invention, the present invention provides a skin external composition for improving seborrheic skin inflammation containing Aletris spicata extract as an active ingredient.

According to one embodiment, it is preferable that the skin is the scalp.

According to one embodiment, it is preferable that the content of the rattail extract is 0.001 to 10% by weight based on the total weight of the composition.

According to one embodiment, it is preferable that the composition improves seborrheic scalp inflammation by suppressing excessive production of sebum by the causative agent of seborrheic scalp inflammation.

According to one embodiment, it is preferable that the composition improves seborrheic scalp inflammation by suppressing the promotion of inflammatory cytokine expression by the causative bacteria of seborrheic scalp inflammation.

According to one embodiment, it is preferable that the composition improves seborrheic scalp inflammation by inhibiting the lipase enzyme activity of the causative agent of seborrheic scalp inflammation.

According to one embodiment, the causative bacteria of seborrheic scalp inflammation are preferably Malassezia globosa and Malassezia restricta .

According to one embodiment, the extract is preferably one or more extracts selected from the group consisting of water, organic solvents, and mixtures thereof.

The extract is preferably one or more extracts selected from the group consisting of water, an organic solvent, and a mixture thereof after washing and drying the rat tail grass well. The organic solvent may be at least one selected from the group consisting of methanol, ethanol, propyl alcohol, butyl alcohol, glycerin, propylene glycol, and butylene glycol having 1 to 10 carbon atoms.

According to one embodiment, the composition is a group consisting of solutions, suspensions, emulsions, pastes, lotions, powders, soaps, surfactant-containing cleansing oils, powder foundations, emulsion foundations, wax foundations, shampoos, rinses, tonics and sprays It is preferred to have a formulation selected from

According to one embodiment, it is preferable that the composition for external application for skin is a cosmetic composition for improving scalp conditions.

According to one embodiment, it is preferable that the composition for external application for skin is a quasi-drug composition for improving scalp condition.

The composition according to the present invention has an effect of suppressing excessive production of sebum caused by a causative agent of seborrheic skin inflammation.

The composition according to the present invention has an effect of inhibiting the expression of inflammatory cytokines caused by seborrheic skin causative bacteria.

The composition according to the present invention has the effect of inhibiting the lipase enzyme activity of the causative agent of seborrheic skin inflammation.

The composition according to the present invention improves the scalp condition deteriorated by seborrheic scalp inflammation-causing bacteria while having safety without adversely affecting skin cells, so it can be used as cosmetics, personal care products, pharmaceuticals, and the like.

Hereinafter, the present invention will be described in more detail.

In order to achieve the object of the present invention, the present invention provides a skin external composition for improving seborrheic skin inflammation containing Aletris spicata extract as an active ingredient.

The rat tail grass is a perennial grass of the monocotyledonous plant Liliaceae Liliaceae, and the leaves come out in a pile from the thick and short rhizome and are bent back. Leaves are line-shaped, 15-30 cm long, 3-7 mm wide, with 3 veins, pointed ends, and flat edges. Any of the flowers, leaves, fruits, stems, roots, or seeds can be used for the extract of the rattail grass, and whole plants can be used.

The extract of oleifera may be one or more extracts selected from the group consisting of leaves, flowers, fruits, stems, roots, and seeds of oleracea, and a whole plant may be used.

According to one embodiment, it is preferable that the skin is the scalp. The skin to which the composition according to the present invention can be used may be face skin, hand skin, body skin, etc., and may be preferably applied to the scalp.

According to one embodiment, it is preferable that the content of the extract of oleracea is 0.001 to 10% by weight, more preferably 0.01 to 5% by weight, and even more preferably 0.02 to 3% by weight, based on the total weight of the composition. . If the content of the rat tail extract is less than 0.001% by weight, the effect of improving seborrheic dermatitis is insignificant, and if it is included more than 10% by weight, skin irritation and trouble may occur.

An effective effect cannot be exhibited when the content of the extract of oleracea extract is less than 0.001% by weight, and when it exceeds 10% by weight, problems with formulation stability such as discoloration and odor may occur.

According to one embodiment, it is preferable that the composition improves seborrheic scalp inflammation by suppressing excessive production of sebum by a causative agent of seborrheic skin or scalp inflammation. There are various methods for improving seborrheic dermatitis, but in the present invention, it is preferable to use a method for suppressing excessive sebum production of seborrheic skin inflammation-causing bacteria.

According to one embodiment, it is preferable that the composition improves seborrheic scalp inflammation by suppressing the promotion of inflammatory cytokine expression by the causative bacteria of seborrheic scalp inflammation.

According to one embodiment, it is preferable that the composition improves seborrheic scalp inflammation by inhibiting the lipase enzyme activity of the causative agent of seborrheic scalp inflammation.

According to one embodiment, the causative bacteria of seborrheic scalp inflammation are preferably Malassezia globosa and Malassezia restricta .

The “extract” includes all substances obtained by extracting the components of natural substances, regardless of the extraction method, extraction solvent, extracted component or extract form, and also extracts the substances obtained by extracting the components of natural substances and then extracts them by other methods. It is a broad concept that includes all materials that can be obtained by processing or processing, and specifically, the processing or processing may be additionally fermenting or enzymatically treating the extract. It is a broad concept including, specifically, in the present specification, the extract may be an extract of water or an organic solvent.

In one embodiment of the present invention, hot water extraction, ethanol extraction, heat extraction, cold extraction, reflux extraction, reflux cooling extraction, or ultrasonic extraction may be used for extraction, and any extraction method known to those skilled in the art is not limited, Hot water extraction, ethanol extraction can be used.

In one aspect of the present invention, extraction may be performed at room temperature, but for more efficient extraction, it may be performed under heated conditions, preferably at about 40 to 100 ° C., more preferably at about 80 ° C. It can be done, but is not limited thereto. The extraction time may be about 2 to about 14 hours, specifically 8 to 14 hours, more specifically 11 to 13 hours, and most specifically 12 hours, but is not limited thereto, and the extraction solvent and extraction It may vary depending on conditions such as temperature. The extraction may be performed one or more times in order to obtain a larger amount of the active ingredient, preferably 1 to 5 times, more preferably 3 consecutive times, and combined extracts may be used.

Specifically, the extract is preferably one or more extracts selected from the group consisting of water, organic solvents, and mixtures thereof. For example, the extraction solvent includes purified water, alcohol having 1 to 15 carbon atoms, ketones, ethers, aromatic ring compounds, and the like.

The extract is preferably one or more extracts selected from the group consisting of water, an organic solvent, and a mixture thereof after washing and drying the rat tail grass well. The organic solvent may be at least one selected from the group consisting of methanol, ethanol, propyl alcohol, butyl alcohol, glycerin, propylene glycol, and butylene glycol having 1 to 10 carbon atoms.

The extract or a soluble fraction of the extract may be used as it is, but may be used in the form of an extract after being concentrated after filtration, or may be used in the form of a dried product after being concentrated.

According to one embodiment, drying may be evaporation drying, spray drying, freeze drying, and specifically, freeze drying may be performed at -50 to -70 ° C for 3 to 4 days during freeze drying.

According to one embodiment, the composition is a group consisting of solutions, suspensions, emulsions, pastes, lotions, powders, soaps, surfactant-containing cleansing oils, powder foundations, emulsion foundations, wax foundations, shampoos, rinses, tonics and sprays It is preferred to have a formulation selected from

When the formulation of the cosmetic composition according to one aspect of the present invention is a paste, cream or gel, animal fibers, vegetable fibers, wax, paraffin, starch, tracanth, cellulose derivatives, polyethylene glycol, silicone, bentonite, silica, talc as carrier components Alternatively, zinc oxide or the like may be used.

When the formulation of the cosmetic composition according to one aspect of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as a carrier component, and in particular, in the case of a spray, additionally propellants such as chlorofluorohydrocarbons, propane/butane or dimethyl ether.

When the formulation of the cosmetic composition according to one aspect of the present invention is a solution or emulsion, a solvent, solvating agent or emulsifying agent is used as a carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1,3-butylglycol oil, glycerol aliphatic esters, polyethylene glycol or fatty acid esters of sorbitan.

When the formulation of the cosmetic composition according to one aspect of the present invention is a suspension, water, a liquid diluent such as ethanol or propylene glycol, ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester and The same suspending agent, microcrystalline cellulose, aluminum metahydroxide, bentonite, agar or tracanth, and the like can be used.

In the case of surfactant-containing cleansing of the cosmetic composition according to one aspect of the present invention, as carrier components, aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, methyl taurate, sarco Cinates, fatty acid amide ether sulfates, alkylamidobetaines, fatty alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, linolin derivatives, or ethoxylated glycerol fatty acid esters may be used.

The cosmetic composition according to one aspect of the present invention may further include functional additives and ingredients included in general cosmetic compositions, in addition to the extract of oleracea japonica. The functional additive may include a component selected from the group consisting of water-soluble vitamins, oil-soluble vitamins, high-molecular peptides, high-molecular polysaccharides, sphingolipids, and seaweed extracts.

In one aspect of the present invention, the cosmetic composition may further contain components included in general cosmetic compositions as necessary in addition to the above functional additives. Ingredients other than those included include fats and oils, moisturizers, emollients, surfactants, organic and inorganic pigments, organic powders, ultraviolet absorbers, preservatives, bactericides, antioxidants, plant extracts, pH adjusters, alcohols, pigments, fragrances, blood circulation accelerators, cooling agents, antiperspirants, purified water and the like.

The external skin preparation is a general term that may include anything applied to the outside of the skin, and cosmetics of various formulations may be included here.

According to one embodiment, it is preferable that the composition for external application for skin is a cosmetic composition for improving scalp conditions.

According to one embodiment, it is preferable that the composition for external application for skin is a quasi-drug composition for improving scalp conditions.

The pharmaceutical composition according to one aspect of the present invention may be in various oral or parenteral dosage forms. When formulated, it is prepared using diluents or excipients such as commonly used fillers, extenders, binders, wetting agents, disintegrants, and surfactants. Solid preparations for oral administration include tablets, pills, powders, granules, soft or hard capsules, etc. These solid preparations contain at least one excipient such as starch, calcium carbonate, and sucrose in one or more compounds. Alternatively, it is prepared by mixing lactose and gelatin. In addition to simple excipients, lubricants such as magnesium stearate and talc are also used. Liquid preparations for oral administration include suspensions, solutions for oral administration, emulsions, syrups, etc. In addition to water and liquid paraffin, which are commonly used simple diluents, various excipients such as wetting agents, sweeteners, aromatics, and preservatives may be included. there is. Formulations for parenteral administration include sterilized aqueous solutions, non-aqueous solvents, suspensions, emulsions, freeze-dried formulations, and suppositories. Propylene glycol, polyethylene glycol, vegetable oils such as olive oil, and injectable esters such as ethyl oleate may be used as non-aqueous solvents and suspending agents. suppositories

As the zero, witepsol, macrogol, tween 61, cacao paper, laurin paper, glycerogelatin, and the like may be used.

In one aspect of the present invention, the pharmaceutical dosage form of the composition may be used in the form of a pharmaceutically acceptable salt thereof, and may also be used alone or in combination with other pharmaceutically active compounds as well as in a suitable set.

The salt is not particularly limited as long as it is pharmaceutically acceptable, and examples thereof include hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, hydrofluoric acid, hydrobromic acid, formic acid, tartaric acid, lactic acid, citric acid, fumaric acid, maleic acid, succinic acid, and methanesulfonic acid. , benzenesulfonic acid, toluenesulfonic acid, naphthalenesulfonic acid and the like can be used.

In one aspect of the present invention, the composition can be administered parenterally or orally as desired, and is administered in an amount of 0.1 to 500 mg per 1 kg of body weight per day, preferably 1 to 100 mg, 1 to several times. It can be divided into doses.

The dosage for a specific patient may vary depending on the patient's weight, age, sex, health condition, diet, administration time, administration method, excretion rate, severity of the disease, and the like.

The pharmaceutical composition according to one aspect of the present invention, according to a conventional method, oral formulations such as powders, granules, tablets, soft or hard capsules, suspensions, emulsions, syrups, aerosols, external skin preparations such as ointments and creams, It may be formulated and used in any form suitable for pharmaceutical preparations, including suppositories, injections, and sterile injection solutions, etc., and may be preferably formulated and used in the form of injections or external skin preparations.

The composition according to one aspect of the present invention can be administered to mammals such as rats, mice, livestock, and humans through various routes such as parenteral and oral, and all methods of administration can be expected, for example, It can be administered orally, transdermally, rectal or intravenous, intramuscular, subcutaneous, intrauterine intrathecal or intracerebroventricular injection.

In one aspect of the present invention, the food composition may be a health functional food composition. The formulation of the food composition according to one aspect of the present invention is not particularly limited, but may be formulated into, for example, tablets, granules, powders, liquids such as drinks, caramels, gels, bars, and the like. The food composition of each formulation can be selected and blended without difficulty by those skilled in the art according to the formulation or purpose of use other than the active ingredient, and synergistic effects can occur when applied simultaneously with other ingredients.

In the food composition according to one aspect of the present invention, the dosage determination of the active ingredient is within the level of those skilled in the art, and its daily dosage is, for example, 0.1 mg/kg/day to 5000 mg/kg/day, more specifically It may be 50 mg/kg/day to 500 mg/kg/day, but is not limited thereto, and may vary depending on various factors such as the age, health condition, and complications of the subject to be administered.

The food composition according to one aspect of the present invention is, for example, various foods such as chewing gum, caramel products, candies, frozen confectionery, and confectionery, beverage products such as soft drinks, mineral water, and alcoholic beverages, and health products including vitamins and minerals. It may be functional foods.

In addition to the above, in one aspect of the present invention, the food composition is various nutrients, vitamins, minerals (electrolytes), flavors such as synthetic flavors and natural flavors, colorants and enhancers (cheese, chocolate, etc.), pectic acid and its salts, alginic acid and its salts, organic acids, protective colloidal thickeners, pH adjusters, stabilizers, preservatives, glycerin, alcohols, carbonating agents used in carbonated beverages, and the like. In addition, in one aspect of the present invention, functional food compositions may include natural fruit juice, fruit juice beverages, and fruit flesh for preparing vegetable beverages. These components may be used independently or in combination. The ratio of these additives is not so critical, but in one aspect of the present invention, it is generally included in the range of 0 to about 20 parts by weight per 100 parts by weight of the composition.

Hereinafter, the configuration and effects of the present invention will be described in more detail with examples and test examples. However, these examples and test examples are provided only for illustrative purposes to aid understanding of the present invention, and the scope and scope of the present invention are not limited by the following examples.

The extract of oleifera may be one or more extracts selected from the group consisting of leaves, flowers, fruits, stems, roots, and seeds of oleracea, and a whole plant may be used.

[Preparation Example] Preparation of rat tail extract

After collecting 100 g of the grass tail grass, 5 L of 70% ethanol aqueous solution was added, cooled at room temperature for 48 hours, filtered, and concentrated under reduced pressure to obtain 15 g of the extract. To conduct cell experiments, samples were prepared by dissolving the extract in dimethyl sulfoxide (DMSO).

Experimental Example 1 Human sebaceous gland cells and skin keratinocyte culture conditions

Human sebocytes were purchased from Celprogen (USA) and used. As the culture medium, Human sebocyte complete media with serum (M36079-01S, Celprogen, USA) was used and cultured at 37°C and 5% CO ₂ conditions.

Normal Human Epidermal Keratinocyte (NHEK) was purchased from ATCC (USA) and used. As the culture medium, Dermal cell basal medium (ATCC, USA) supplemented with Keratinocyte growth kit (ATCC, USA) was used and cultured at 37°C and 5% CO ₂ conditions.

Experimental Example 2 Malassezia restricta and Malassezia globosa culture conditions

조건에서 배양하고, 3일에 한번씩 계대 배양을 시행하였다. Malassezia restricta ( M.restricta , KCTC 27527) and Malassezia globosa ( M.globosa , KCTC 27535) used in the experiment were purchased from the Biological Resources Center (KCTC) of the Korea Research Institute of Bioscience and Biotechnology. The culture medium was 32 using Leeming and Notman (LNA).

Conditions were cultured, and subculture was performed once every 3 days.

Experimental Example 3 Malassezia Induction of seborrheic scalp inflammatory environment in cell experimental model through yeast culture solution treatment

M.restricta (5X10 ⁵ ) and M.globosa (1X10 ⁶ ), which are known to be frequently found in seborrheic scalpitis, were each inoculated into 20 ml LNA medium and cultured for 72 hours. Through a preliminary experiment, it was confirmed that the culture medium ratio condition that promotes sebaceous gland cell proliferation and intracellular sebum production the most was M.restricta culture medium: M.globosa culture medium = 9:1 (cell culture medium treated with 2.5% (v/v)). In subsequent tests, it was used as an inducer of seborrheic scalp inflammation environment.

Experimental Example 4 Malassezia Inhibitory effect on excessive sebum production induced by yeast

The inhibitory effect of excessive sebum production by the causative bacteria of seborrheic scalp inflammation of the extract of rattail grass of the present invention was evaluated by Oil Red O staining method. Sebaceous gland cells were seeded in a 24-well plate at a concentration of 1X10 ⁵ cells/well and cultured for 24 hours. After removing the culture medium, sebum production was induced by treating Malassezia yeast culture medium (M36079-01, Celprogen, USA) in Human sebocyte serum free media (M36079-01, Celprogen, USA) as described in Experimental Example 3, and sebum production was achieved by simultaneous treatment with the extract of Porphyra sinensis by concentration. The inhibitory effect was confirmed. In order to measure the sebum production inhibitory effect, the following process was performed in more detail. After simultaneous treatment of Malassezia yeast culture medium and rattail extract for 48 hours, the cells washed with PBS were fixed with a 10% formaldehyde solution for 30 minutes. The fixed cells were washed twice with PBS and once with 50% isopropanol, and stained with 0.4% Oil Red O solution for 45 minutes. Stained cells were washed once with 70% ethanol and twice with PBS. After washing and sufficiently drying the well plate, the oil red O solution stained with 100% isopropanol was dissolved again, and the absorbance was measured at 520 nm using a micro-plate reader to quantify the amount of neutral fat produced in the cells.

The measurement results are shown in Table 1 below.

sample Sebum production rate (%) Sebum production inhibition rate (%) untreated control 100 - LNA medium control 131.29 - M.restricta : M.globosa = 9:1 (M) 232.34 0 M+ Rattail extract 25 ppm 188.14 19.02 M+ Rattail extract 100 ppm 181.74 21.78

As shown in Table 1 above, the Malassezia yeast culture solution significantly induces sebum production compared to the untreated control and the LNA medium control, and the extract of rattail grass used as an active ingredient in the composition of the present invention produces sebum induced by the Malassezia yeast culture solution. It was confirmed that it effectively inhibited .

Experimental Example 5 Malassezia Inhibitory effect of inflammatory cytokine expression in yeast-derived human sebaceous gland cells and skin keratinocytes

The inhibitory effect of the extract of the present invention on seborrheic scalp inflammation induced by the culture medium of Malassezia yeast was evaluated by measuring the expression of inflammatory cytokines in human sebaceous gland cells and skin keratinocytes. As described in Experimental Example 3, seborrheic scalp inflammation was induced by treating the culture medium of Malassezia yeast bacteria, and 100 ppm of oleracea extract was simultaneously treated for 24 hours. After 24 hours, the expression level of inflammatory cytokines (IL-6, IFN-γ) expressed in each cell culture medium was measured in the cell culture medium through an ELISA kit. ELISA was performed using Rnd systems (IL-6: DY206-05 / IFN-γ: DY285B-05) according to the manufacturer's recommended method.

The measurement results are shown in Table 2 below.

sample experiment cell inflammatory cytokines Expression inhibition rate (%) Rattail extract (100 ppm) human skin keratinocytes
(NHEK) IL-6 12.35 Human Sebocyte IFN-γ 43.42

As shown in Table 2, it was confirmed that the Malassezia yeast culture medium induces an inflammatory response by increasing the expression of inflammatory cytokines in human skin keratinocytes and sebaceous gland cells. It can be seen that the rattail extract of the present invention effectively inhibits the expression of inflammatory cytokines expressed in each cell, and thus has an effect of calming seborrheic scalp inflammation.

Experimental Example 6 Malassezia globosa ( M. globosa ) Lipase enzyme activity inhibitory effect

Lipase secreted by M. globosa breaks down triglycerides and esters, which are components of sebum, to produce linoleic acid and oleic acid, unsaturated fatty acids with skin irritation. The lipase activity inhibitory effect produced by M.globosa of rattail extract was evaluated through Lipase assay (Lipolytic enzyme activity), and specifically, the following process was performed. Add 30 μl of 90 mM citrate buffer, 30 μl of 10 mM p-NPD (4-Nitrophenyl dodecanoate), 30 μl of 5% Triton X-100, and 610 μl of Tris-HCl buffer (pH 8.0) to 100 μl of M.globosa culture medium. Enzyme buffer was prepared. As a positive control, 100 μM of Quercetin and 100 μl of rattail extract by concentration were added to the enzyme buffer and reacted at 30 ° C for 1 hour. The degree of hydrolysis of p-NPD to p-nitrophenol was measured by absorbance at 405 nM.

The measurement results are shown in Table 3 below.

sample Lipase activity inhibition rate (%) M. globosa culture (M) - M+Quercetin 100 µM 27.28 M+ Rattail extract 125 ppm 20.57 M+ Rattail extract 500 ppm 25.58

As shown in Table 3, it was confirmed that the rattail extract effectively inhibited the lipase enzyme activity produced by M. globosa , indicating that it was effective in inhibiting the production of skin-irritating unsaturated fatty acids that cause seborrheic scalpitis.

formulation example

Below, various examples of formulations of the scalp application composition containing the extract of the present invention will be described, but the present invention is not intended to limit them, but only to specifically describe them.

shampoo ingredient name Content (% by weight) rat tail extract 1.0 sodium lauryl sulfate 10 Cocamidopropyl Betaine 3 carboxylvinyl polymer 0.3 Polyquaternium-10 0.2 Spices 0.7 Methylparaben 0.2 Cetyltrimethylammonium chloride 0.1 Purified water balance

Rinse ingredient name Content (% by weight) rat tail extract 1.0 cetyl alcohol 2 Stearyl Alcohol 2.5 behenyl alcohol 0.5 Spices 0.4 silicone emulsion 0.4 cyclomethicone 1.0 Dimethyldistearylammonium chloride 0.1 citric acid Amount adjustable from pH 3 to 7 Purified water balance

ample ingredient name Content (% by weight) rat tail extract 1.0 ethanol 30 propylene glycol 20 1,3-butylene glycol 10 Cetyltrimethylammonium chloride 3 diethyldistearylammonium chloride 0.1 lauryl alcohol 3 myristyl alcohol 5 cetyl alcohol One Spices 0.5 dyes Appropriate amount Purified water balance

tonic ingredient name Content (% by weight) rat tail extract 1.0 ethanol 40 propylene glycol 10 Polysorbate 20 5 Spices 0.5 dyes Appropriate amount Purified water balance

Claims (12)

A composition for topical skin application for improving seborrheic skin inflammation, comprising an extract of Aletris spicata as an active ingredient. According to claim 1,
A composition for external application for skin, characterized in that the skin is a scalp. According to claim 1,
The composition for external application for skin, characterized in that the content of the extract of the rattail extract is 0.001 to 10% by weight based on the total weight of the composition. According to claim 1
The composition for external application for skin, characterized in that the composition suppresses the excessive production of sebum by the causative agent of seborrheic scalp inflammation. According to claim 1
The composition for external application for skin, characterized in that for suppressing the promotion of inflammatory cytokine expression by the causative agent of seborrheic scalp inflammation. According to claim 1
The composition for external application for skin, characterized in that the composition inhibits the lipase enzyme activity of the causative agent of seborrheic scalp inflammation. According to claim 5,
The seborrheic scalp inflammation causative bacteria are Malassezia globosa and Malassezia restricta composition for external application for skin, characterized in that. According to claim 1
The extract is an external composition for skin, characterized in that at least one extract selected from the group consisting of water, organic solvents and mixtures thereof. According to claim 8,
The organic solvent is an external composition for skin, characterized in that at least one selected from the group consisting of methanol, ethanol, propyl alcohol, butyl alcohol, glycerin, propylene glycol and butylene glycol having 1 to 10 carbon atoms. According to claim 1
The composition has a formulation selected from the group consisting of solutions, suspensions, emulsions, pastes, lotions, powders, soaps, surfactant-containing cleansing oils, powder foundations, emulsion foundations, wax foundations, shampoos, rinses, tonics and sprays. A composition for external application for skin, characterized in that. According to any one of claims 1 to 10,
The composition for external application for skin, characterized in that the composition for external application for skin is a cosmetic composition for improving scalp conditions. According to any one of claims 1 to 10,
The composition for external application for skin, characterized in that the composition for external application for skin is a quasi-drug composition for improving scalp condition.