KR20220151931A - Cosmetic composition for improving acne skin - Google Patents

Abstract

The present invention relates to a cosmetic composition for alleviating acne prone skin. More specifically, the cosmetic composition according to the present invention does not irritate the skin when applied to the skin, has safety when applied to the human body, has an excellent acne skin alleviation effect, and at the same time, promotes the normalization of acne prone skin, and thus can be usefully used as a cosmetic composition for alleviating acne prone skin. The cosmetic composition for alleviating acne skin of the present invention comprises gluconolactone as an active ingredient.

Description

Cosmetic composition for improving acne skin {COSMETIC COMPOSITION FOR IMPROVING ACNE SKIN}

The present invention relates to a cosmetic composition for improving acne skin, and the cosmetic composition according to the present invention is non-irritating when applied to the skin, has safety to the human body, has an excellent acne skin improvement effect, and promotes normalization of acne skin. It can be usefully used as a cosmetic composition for skin improvement.

Recently, due to frequent wearing of masks due to fine dust and COVID-19, the skin has become sensitive, resulting in a lot of skin-related troubles such as acne, and the demand for products that can manage them is rapidly increasing.

Acne is an inflammatory skin disease that appears in the sebaceous glands of the skin, and refers to folliculitis that mainly occurs on the face of the human body, especially the cheeks and forehead. The main causes of acne include increased secretion of sebum by male hormones, excessive keratinization of the skin, and inflammation caused by the proliferation of Propionibacterium Acnes , in addition to genetic and environmental factors. It is known that acne occurs due to a combination of factors such as , , and reactivity of hair follicles.

Acne treatment is generally done by reducing sebum secretion, softening hair follicles and keratin, reducing bacteria in hair follicles, and blocking acne from developing into inflammation. Methods for this include topical application therapy and oral medications. There are oral therapies and surgical therapies.

Among the above therapies, the topical agent application therapy is aimed at antibacterial action against Propionibacterium acnes, known as the causative agent of acne, and uses antibacterial agents such as Azelaic acid and Salicylic acid (BHA). Or use benzoyl peroxide to dissolve comedones. However, azelaic acid is difficult to formulate and is prohibited from being formulated in cosmetics, and in the case of salicylic acid, the Ministry of Food and Drug Safety designates it as the main ingredient for acne functional cosmetics, and many products using it are released, but salicylic acid-containing products It corresponds to Hwahae and EWG Yellow grades and is a cautionary ingredient, and there is a problem that it is not easy to control the content as it is an ingredient with a designated mixing limit. In addition, in the case of benzoyl peroxide, there is a problem that it is a raw material that cannot be used as a raw material for cosmetics in Korea.

Oral medication therapy aims at inhibiting sebaceous gland function and hair follicle wall destruction, and uses retinoids, hormones, and the like. However, they have side effects such as skin rash, skin dryness, allergy induction when overdosed, and in the case of hormone drugs, epidermal growth inhibition or other side effects of hormone abuse have been reported.

In addition, recently, attempts have been made to develop cosmetics for improving acne skin that can be used continuously because they can reduce the side effects while having an anti-acne bacteria effect using plant extracts, etc., but the effect is insignificant or it is difficult to mass-produce. There are problems such as difficulty in extracting and separating active ingredients.

Recognizing the problems of the prior art, the present inventors have tried to develop a new cosmetic composition for improving acne skin that can supplement the problems of conventional methods for improving acne skin while having excellent acne skin improvement effects.

As a result, the composition containing gluconolactone as an active ingredient has no skin irritation, is safe when applied to the human body, has lipid (sebum) synthesis inhibitory ability and antibacterial activity against the acne bacterium Propionibacterium acnes, improving acne skin It was proved that it can be usefully used as a cosmetic composition for use and came to complete the present invention.

The present invention relates to a cosmetic composition for improving acne skin containing gluconolactone as an active ingredient.

Hereinafter, this will be described in detail. All combinations of the various elements disclosed herein fall within the scope of the present invention. In addition, it cannot be seen that the scope of the present invention is limited by the specific description below.

The present invention provides a cosmetic composition for improving acne skin containing gluconolactone as an active ingredient.

In the present invention, “Gluconolactone (C ₆ H ₁₀ O ₆ )” means one type of polyhydroxy acid (PHA) represented by Formula 1 below.

[Formula 1]

Since the gluconolactone has a large molecular weight, it has less skin irritation compared to alpha hydroxy acid (α-hydroxy acid, AHA) components, maintains the skin surface in a healthy state, and restores the skin barrier function to maintain young and healthy skin. Conventionally, it has been used as a peeling material.

In the present invention, gluconolactone was used as an active ingredient of a composition for improving acne skin, and according to experimental examples described later, a composition containing gluconolactone was safe when applied to the human body and synthesized lipid (sebum). It has been proven that it can be usefully used for improving acne skin by having inhibitory and antibacterial effects against acne bacteria.

The cosmetic composition of the present invention may contain gluconolactone in an amount of 0.1 to 30% (w/w) based on the total composition, preferably in an amount of 1 to 30% (w/w), more preferably It may be contained in 1 to 10% (w / w), but is not limited thereto.

When the gluconolactone is included in the composition in an amount less than the above range, the acne skin improvement effect may be insignificant. It can cause side effects such as irritation.

The cosmetic composition of the present invention may further include an anti-acne raw material or extract capable of exhibiting a synergistic effect within a range that does not damage or inhibit the acne skin improvement effect, which is the object of the present invention, and various Additives may be further included.

According to embodiments of the present invention, the cosmetic composition is an emulsion stabilizer, a viscosity increasing agent, a surfactant, an emollient, a humectant, and a film former It may further include one or more selected from the group consisting of, but is not limited thereto.

The cosmetic composition of the present invention may have a pH of 2.5 to 7.0, preferably a slightly acidic or slightly acidic pH of 2.5 to 5.5, and more preferably a slightly acidic pH of 3.0 to 5.0.

Human skin is slightly acidic, and skin-related problems may occur if the skin is alkaline. Actual acne skin is known to have a pH of 7.5 and atopic skin has a pH of 8.0, so maintaining a slightly acidic or slightly acidic state of the skin may be advantageous for mitigating or improving skin diseases outside the pH range of normal skin.

According to the experimental examples described later, it was confirmed that gluconolactone exhibits excellent antibacterial activity against Propionibacterium acnes at the pH in the above range, and the lower the pH, the higher the antibacterial activity of gluconolactone. confirmed (Tables 2 to 4). Without being bound by a particular theory, it is believed that the activity of gluconolactone is improved as the pH is lowered, thereby exhibiting excellent antibacterial activity.

The cosmetic composition of the present invention may have an effect of improving acne through the activity of inhibiting lipid (sebum) synthesis.

In the occurrence of acne, excessive secretion of sebum by hormones that control sebum secretion is one of the main causes of acne. Specifically, testosterone, a male hormone, is converted into dihydrotestosterone (DHT) by 5α-reductase, and the DHT binds to DNA of sebaceous gland cells to induce proliferation of sebaceous gland cells, As a result, the synthesis of lipid components is activated and sebum is secreted excessively, which causes acne. Therefore, having lipid (sebum) synthesis inhibitory activity means that it can have an effect of improving acne skin.

In experimental examples to be described later, it was specifically demonstrated that the cosmetic composition of the present invention has an activity of inhibiting lipid (sebum) synthesis (Table 1 and Figure 1), which indicates that the cosmetic composition of the present invention has an acne skin improvement effect. indicates a point.

According to one embodiment of the present invention, the concentration of gluconolactone to exhibit lipid (sebum) synthesis inhibitory activity is 0.1% (w/w) or more, preferably 0.1 to 30% (w/w). However, it is not limited thereto.

The cosmetic composition of the present invention may have an effect of improving acne skin through anti-acne bacteria activity.

In the present invention, "anti-acne bacteria" means the ability to resist acne bacteria, and means all activities made to protect the skin from the inflammation-inducing action caused by the proliferation of acne-causing bacteria, which is one of the main causes of acne.

In the present invention, the acne bacillus is Propionibacterium acnes , Staphylococcus aureus , Staphylococcus epidermidis , or pyogenic streptococcus ( Sreptococcus ). pyogenes ), and according to one embodiment of the present invention, the cosmetic composition of the present invention may have antibacterial activity against Propionibacterium acnes, but is not limited thereto.

The Propionibacterium acnes is an anaerobic bacterium residing in the hair follicle, and secretes lipolytic enzyme to decompose neutral fat in sebum and form free fatty acid, and the formed free fatty acid stimulates the skin to stimulate the hair follicle wall or pores It causes inflammation in the surrounding cells and causes acne. Therefore, having an antibacterial activity against Propionibacterium acnes means that it can have an acne skin improvement effect.

According to the experimental examples described later, it was demonstrated that the cosmetic composition of the present invention has excellent antibacterial activity against the acne bacterium Propionibacterium acnes (Tables 2 to 4), which indicates that the cosmetic composition of the present invention has excellent acne This indicates that it has a skin-improving effect.

According to one embodiment of the present invention, the concentration of gluconolactone to have antibacterial activity against Propionibacterium acnes may be 0.1 to 30% (w/w), preferably 1 to 30% (w/w). w), more preferably 1 to 10% (w/w), but is not limited thereto.

In the present invention, the cosmetic composition may have a lipid synthesis inhibitory activity and anti-acne bacteria activity at the same time, thereby improving acne skin. As confirmed in the experimental examples described below, the composition of the present invention can simultaneously suppress the increase in sebum secretion, which is the main cause of acne, and the induction of inflammation due to the propagation of Propionibacterium acnes, thereby maximizing the effect of improving acne skin. can

The cosmetic composition of the present invention can be implemented in a stable formulation, and can be formulated in various formulations while minimizing changes in the potency of active ingredients.

The cosmetic composition is, for example, astringent lotion, softening lotion, nutrient lotion, eye cream, massage cream, essence, oil, powder, body products, packs, masks, products around the eyes, lotions, creams, skin softening products for hands and feet , cleansing water, cleansing oil, cleansing lotion, cleansing cream, and other basic makeup products; It may be formulated into a foam cleanser, body cleanser, liquid soap and cosmetic soap, vulva cleanser, wet tissue, and other human body cleansing products, but is not limited thereto.

The cosmetic composition according to the present invention is non-irritating when applied to the skin, has safety when applied to the human body, has an excellent acne skin improvement effect, and promotes the normalization of acne skin, so it can be usefully used as a cosmetic composition for improving acne skin.

1 shows the results of confirming the ability of the composition of the present invention to inhibit lipid (sebum) synthesis.

Hereinafter, the present invention will be described in more detail by examples. However, these examples are intended to illustrate the present invention by way of example, and the scope of the present invention is not limited by these examples. In addition, terms not specifically defined in this specification should be understood to have meanings commonly used in the technical field to which the present invention belongs.

Experimental example 1. Lipid Synthesis inhibitory ability evaluation

In order to confirm whether the composition of the present invention has the ability to inhibit lipid synthesis, human sebum secreting cells (SZ95) were treated with various samples, stained with Oil-red-O, and absorbance was measured at 500 nm using a microplate reader. The inhibition rate of lipid (sebum) synthesis was confirmed, and the results are shown in Table 1 and FIG.

Gluconolactone Concentration (mg/ml) Lipid (sebum) synthesis inhibition rate ( % ) 0.6 - 0.8 7±2.9 1.0 49±1.2 1.2 58±0.4

As can be seen in Table 1 and FIG. 1, when the concentration of gluconolactone is 1.0 mg/ml (0.1% (w/w)) or more, the lipid synthesis inhibition rate of about 50% or more is exhibited, so that the gluconolactone of the present invention It was confirmed that the composition comprising the above can be usefully used as a cosmetic composition for improving acne.

Experimental example 2. Evaluation of antibacterial effect against acne bacillus

The anti-acne bacteria effect on Propionibacterium acnes , a causative agent of acne, was confirmed through a disc diffusion method using paper discs for samples of various concentrations under various pH conditions. As a control, triclosan (0.02% (w/w)) and tertiary distilled water were used, and the experimental results are shown in Table 2 (pH 7.0 condition), Table 3 (pH 5.0 condition), and Table 4 (pH 3.0 condition). .

compound clear zone Gluconolactone 0.1% (w/w) - Gluconolactone 1% (w/w) 1.3±0.3 Gluconolactone 5% (w/w) 6.9±0.6 Gluconolactone 10% (w/w) 8.3±1.3 Triclosan 8.9±1.2 tertiary distilled water -

(condition: pH 7.0)

compound clear zone Gluconolactone 0.1% (w/w) 0.9±0.1 Gluconolactone 1% (w/w) 5.0±0.6 Gluconolactone 3% (w/w) 7.1±0.7 Gluconolactone 5% (w/w) 8.0±1.3 Triclosan 9.4±1.1 tertiary distilled water -

(condition: pH 5.0)

compound clear zone Gluconolactone 0.1% (w/w) 1±0.1 Gluconolactone 1% (w/w) 5.8±0.9 Gluconolactone 3% (w/w) 7.9±0.8 Gluconolactone 5% (w/w) 8.5±1.0 Triclosan 10.2±0.8 tertiary distilled water -

(condition: pH 3.0)

As can be seen in Tables 2 to 4, it can be seen that gluconolactone exhibits a significant clear zone at 0.1% (w/w) or more, indicating excellent antibacterial activity against Propionibacterium acnes. In addition, the antibacterial activity increased as the pH decreased, and especially, at a pH of 5.0 or less, strong antibacterial activity was exhibited even at a low concentration of gluconolactone. This confirms that the composition containing gluconolactone of the present invention can be usefully used as an acne treatment.

formulation example

Table 5 below relates to the composition of a cream-type weakly acidic cleanser as an example of a cosmetic composition containing gluconolactone of the present invention.

ingredient Content (unit: % (w/w)) Gluconolactone 0.1 to 30 sodium sulfate 1 to 10 Sodium Lauryl Sulfoacetate 1 to 20 sodium isethionate 1 to 20 sodium cocoyl isethionate 1 to 20 sodium cocoyl alaninate 1 to 20 sodium chloride 1 to 20 myristyl alcohol 0.1 to 10 Lauryl Alcohol 0.1 to 10 glycerin 1 to 40 Coconut Acid 0.1 to 10 cetyl alcohol 0.1 to 10 Acrylate Copolymer 0.1 to 10 Purified water balance

Claims (8)

A cosmetic composition for improving acne skin comprising gluconolactone as an active ingredient. According to claim 1,
The cosmetic composition for improving acne skin, wherein the gluconolactone is contained in an amount of 0.1 to 30% (w/w) relative to the total composition. According to claim 1,
The cosmetic composition for improving acne skin, wherein the gluconolactone is contained in an amount of 1 to 10% (w/w) relative to the total composition. According to claim 1,
The composition further contains at least one selected from the group consisting of an emulsion stabilizer, a viscosity increasing agent, a surfactant, an emollient, a humectant, and a film former. A cosmetic composition for improving acne skin comprising: According to claim 1,
The composition is a cosmetic composition for improving acne skin having a pH of 2.5 to 5.5. According to claim 1,
The composition is a cosmetic composition for improving acne skin that has an effect of improving acne skin through lipid synthesis inhibitory activity and anti-acne bacteria activity. According to claim 6,
The acne bacterium is Propionibacterium acnes ( Propionibacterium acnes ) A cosmetic composition for improving acne skin. According to claim 1,
The composition is astringent lotion, softening lotion, nutrient lotion, eye cream, massage cream, essence, oil, powder, body products, packs, masks, products around the eyes, lotions, creams, skin softening products for hands and feet, cleansing water, cleansing A cosmetic composition for improving acne skin formulated with oil, cleansing lotion, cleansing cream, foam cleanser, body cleanser, liquid soap, cosmetic soap, vulvar cleanser or wet tissue.

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