KR20220143282A - A uv protection of diethylamino hydroxybenzoyl hexylbenzoate, plant extracts including pinus rigida mill extracts, and a cosmetic composition comprising the same - Google Patents

Abstract

The present invention relates to a sunscreen composition containing diethylamino hydroxy benzoyl hexylbenzoate (DHHB) and a natural extract as active ingredients. An object of the present invention is to provide a sunscreen raw material with significantly improved sunscreen activity as well as biosafety.

Description

A UV PROTECTION OF DIETHYLAMINO HYDROXYBENZOYL HEXYLBENZOATE, PLANT EXTRACTS INCLUDING PINUS RIGIDA MILL EXTRACTS, AND A COSMETIC COMPOSITION COMPRISING THE SAME

The present invention relates to a sunscreen composition with less skin irritation while significantly improved sunscreen activity.

Sunlight not only maintains the body temperature, but also acts to sterilize the skin and synthesize vitamin D.

However, excessive exposure to sunlight can cause skin burns, photo-sensitive dermatitis, premature aging, and, in severe cases, skin cancer.

Skin changes caused by sunlight include roughness, wrinkles, pigmented spots, poor complexion, capillary dilatation, black spots, purpura, and tumors, and these changes are called photoaging.

Photoaging has a clinical characteristic that causes deeper and more wrinkles than intrinsic aging that cannot be avoided as time goes by.

In the skin exposed to sunlight, irregular pigmentation and pigment diseases such as solar lentigo may increase, and elasticity may decrease due to a decrease in moisture and skin sagging may occur.

Visible light, infrared light, and ultraviolet light exist in sunlight, and ultraviolet light is classified into A (320-400 nm), B (280-320 nm), and C (200-280 nm) depending on the length of the wavelength.

Ultraviolet C is lethal to life, but it is 100% absorbed by the ozone layer and does not reach the earth's surface, so there are no serious concerns about its harmfulness.

On the other hand, ultraviolet B is known to be a direct cause of sunburn, which is frequently experienced when exposed to sunlight for a long time, and ultraviolet A is known to penetrate the dermal layer of the skin to cause skin cancer and aging.

Ultraviolet rays can disrupt the skin immune system by lowering the number of immune cells, and can cause skin cancer by changing DNA, the genetic material.

In addition, the skin structural protein is the greatest risk factor for skin health that promotes phenomena such as deterioration of skin elasticity and wrinkle aging by destroying collagen and elastin. It promotes the development of cosmetics.

UV blocking materials can be divided into organic and inorganic types according to their mechanism of action. Organic blocking materials are based on chemicals that effectively absorb UV rays (ex. Avobenzone, Octylmethoxycinnamate, Benzophenone), and inorganic blocking materials scatter or absorb UV rays to form a photocatalyst. It is being developed based on functional metal oxides (ex. TiO ₂ , ZnO, Fe ₂ O ₃ ).

However, existing organic or inorganic sunscreen materials have various problems such as lowering stability in cosmetic formulations or causing skin problems, and the safety and effectiveness of sunscreens are important topics in cosmetics.

The cosmetics industry is developing a number of products using natural products to reduce skin irritation caused by various chemicals, and the development value as a cosmetic raw material is gradually increasing as consumers' response to cosmetics using natural materials increases.

(Patent Document 1) Republic of Korea Patent No. 10-1965202

(Patent Document 2) Republic of Korea Patent Publication No. 2019-0063213

SUMMARY OF THE INVENTION The present invention is to solve the problems of the prior art described above, and an object of the present invention is to provide a raw material for a sunscreen with significantly improved UV blocking activity along with biosafety.

According to one aspect of the present invention, there is provided a sunscreen composition comprising DHHB (Diethylamino Hydroxy benzoyl HexylBenzoate) and Rigida pine extract as active ingredients.

In one embodiment, the composition may further include a blackberry extract.

In one embodiment, the composition may further include a blueberry extract.

In one embodiment, the composition may have blocking activity against UVA and UVB.

According to another aspect of the present invention, there is provided a cosmetic composition containing the sunscreen composition.

In one embodiment, the cosmetic composition comprises a softening lotion, a nutrient lotion, a moisture cream, a nutrient cream, a massage cream, a nutrient lotion, an essence, an ampoule, a gel, an eye cream, an oil, a foundation, a cleansing cream, a cleansing foam, a cleansing water, It may be formulated with one or more selected from the group consisting of a mask pack, a spray, and a powder.

According to another aspect of the present invention, there is provided a composition for external application for skin containing the sunscreen composition.

In one embodiment, the composition for external application for skin may be formulated with one or more selected from the group consisting of creams, gels, patches, sprays, ointments, warning agents, lotions, liniments, pastas, and cataplasmas.

According to the present invention, the sunscreen composition has excellent human safety by introducing a natural extract together, and it is possible to minimize the content of chemical substances that can cause skin irritation.

The sunscreen composition can significantly enhance the sunscreen activity through the synergistic activity of chemical substances and natural ingredients.

It should be understood that the effects of the present invention are not limited to the above-described effects, and include all effects that can be inferred from the configuration of the invention described in the detailed description or claims of the present invention.

The terms used in this specification have been selected as currently widely used general terms as possible while considering the functions in the present invention, which may vary depending on the intention or precedent of a person skilled in the art, the emergence of new technology, and the like.

In addition, in a specific case, there is a term arbitrarily selected by the applicant, and in this case, the meaning will be described in detail in the description of the corresponding invention. Therefore, the term used in the present invention should be defined based on the meaning of the term and the overall content of the present invention, rather than the name of a simple term.

Unless defined otherwise, all terms used herein, including technical or scientific terms, have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Terms such as those defined in a commonly used dictionary should be interpreted as having a meaning consistent with the meaning in the context of the related art, and should not be interpreted in an ideal or excessively formal meaning unless explicitly defined in the present application. does not

Numerical ranges are inclusive of the values defined in that range. Every maximum numerical limitation given throughout this specification includes all lower numerical limitations as if the lower numerical limitation were expressly written. Every minimum numerical limitation given throughout this specification includes all higher numerical limitations as if the higher numerical limitation were expressly written. All numerical limitations given throughout this specification will include all numerical ranges that are better within the broader numerical limits, as if the narrower numerical limitations were expressly written.

Hereinafter, examples of the present invention will be described in detail, but it is obvious that the present invention is not limited by the following examples.

According to one aspect of the present invention, there is provided a sunscreen composition comprising DHHB (Diethylamino Hydroxy benzoyl HexylBenzoate) and Rigida pine extract as active ingredients.

The sunscreen is a composition having a function of blocking ultraviolet rays in a way such as scattering or absorbing ultraviolet rays. can be reduced.

The "comprising as an active ingredient" refers to a degree that can exhibit a skin improvement effect, for example, collagen synthesis related to wrinkle improvement effect, elasticity improvement or skin aging prevention by ultraviolet rays, skin irritation relief, skin soothing effect, etc. It may mean containing an effective amount of

The DHHB (Diethylamino Hydroxy benzoyl Hexyl Benzoate) is an organic compound that absorbs UVA radiation and has an absorption maximum value of 354 nm, and may be a compound of Formula 1 below.

[Formula 1]

The "Rigida pine ( Pinus rigida Mill )" is an evergreen coniferous tree belonging to the family Pineaceae, native to eastern North America, and is also called a three-leaf pine.

The Rigida pine is distributed nationwide, has a strong germination power, and is known to grow well in dry places or wetlands.

The Rigida pine is known to have antioxidant, antibacterial, and anti-inflammatory effects (Jank et al., 2008), and the effect of regulating blood pressure in patients with mild hypertension (Hosseini et al., 2001) and antithrombotic action (Araghi-Nikna) et al., 2000; Putter et al., 1999) have been reported.

The present inventors completed the present invention by confirming that the DHHB can exhibit a more excellent UV protection effect by acting with the Rigida pine extract.

The "extract" means that the active ingredient contained in the extraction material is separated by contacting the solvent and the extraction material under specific conditions.

The extract may be extracted with one or more solvents selected from the group consisting of purified water, lower alcohols having 1 to 4 carbon atoms, acetone, ethyl acetate, butyl acetate, and 1,3-butylene glycol, and the alcohol is 60 to 90 % concentration (v/v) may be ethanol, but is not limited thereto.

The extraction ratio of the active ingredients contained in the raw material may be different depending on the polarity of the solvent, and since the ethanol has excellent selectivity in extracting the physiologically active substances of natural raw materials, the optimal UV blocking effect may be realized by the ethanol extraction. can

The extract is extracted by conventional methods such as reflux circulation extraction, pressure extraction, ultrasonic extraction, etc. for about 1 hour to 24 hours with a solvent in a volume equivalent to 8 to 12 times the weight of the raw material by washing the natural raw material with water, drying and pulverizing it And it can be prepared by filtration.

In addition, the extract may be obtained in a powder state by an additional process such as distillation under reduced pressure or freeze-drying.

The extract may also include an extract that has undergone a conventional purification process. For example, the extract is separated using an ultrafiltration membrane having a constant molecular weight cut-off value, and various purification methods additionally performed such as separation by various chromatography (those prepared for separation according to size, charge, hydrophobicity or affinity). It may include a fraction obtained through

The composition may further include a blackberry extract.

The “blackberry” is a plant group belonging to the dicotyledonous plant Rosaceae Rosaceae and strawberries, which is rich in various vitamins and can enhance immunity, is good for eye fatigue with high vitamin A content, is rich in dietary fiber, and contains anthocyanins. known to be abundant.

The composition may further include a blueberry extract.

The “blueberry” refers to the fruit of a shrub plant of the genus Rhododendron, and is known to have excellent antioxidant and anti-inflammatory properties because it contains a large amount of anthocyanins and carotenoid pigments.

In addition, the blueberry promotes the activation of retinal rhodopsin resynthesis to reduce eye fatigue and clear vision, and is known to have good effects on urinary tract infections, diarrhea, diabetes, and the like.

The composition may have blocking activity against UVA and UVB.

The ultraviolet rays are sunlight in the wavelength range of 280 to 400 nanometers, and when exposed to excessive ultraviolet rays, skin damage such as skin aging, burns, and skin cancer may be induced.

In particular, the UVA is known to promote skin aging by damaging the skin lipids of the epidermis with ultraviolet rays in the wavelength range of 320 to 400 nanometers or by inducing melanin pigment in the basal layer.

In addition, the UVB is known to directly damage the skin by causing skin erythema, skin burns, etc. with ultraviolet rays in the wavelength range of 280 to 320 nanometers.

The composition can block UVA and UVB at the same time, effectively protecting the skin from UV rays.

According to another aspect of the present invention, there is provided a cosmetic composition and a composition for external application for skin containing the sunscreen composition.

Since the cosmetic composition and the composition for external application for skin include the sunscreen composition, it is possible to effectively block ultraviolet rays harmful to the human body and effectively protect the skin from stimulation by ultraviolet rays.

The cosmetic composition and the composition for external application for skin may be used to prevent photoaging.

The “prevention of photoaging” may be for preventing skin aging induced by ultraviolet rays. The “photoaging” is an aging phenomenon induced by ultraviolet rays, which are external environmental factors.

The ultraviolet rays activate proteolytic enzymes and cause chain cleavage and abnormal cross-linking of matrix proteins, resulting in damage to biological components, and repetition of the mechanism may result in apparent skin aging.

The cosmetic composition and the composition for external application for skin can effectively improve skin aging induced by ultraviolet rays, unlike intrinsic aging caused by genetic factors regardless of external environment.

The cosmetic composition includes a softening lotion, a nourishing lotion, a moisture cream, a nourishing cream, a massage cream, a nourishing lotion, an essence, an ampoule, a gel, an eye cream, an oil, a foundation, a cleansing cream, a cleansing foam, a cleansing water, a mask pack, a spray and a powder It may be formulated with one or more selected from the group consisting of, but is not limited thereto.

In addition, the composition for external application for the skin may be formulated with one or more selected from the group consisting of creams, gels, patches, sprays, ointments, warning agents, lotions, liniments, pastas, and cataplasmas, but is limited thereto not.

The cosmetic composition may be formulated by a conventional method. In the formulation of the cosmetic composition, for example, reference may be made to the contents disclosed in International cosmetic ingredient dictionary, 6th ed (The cosmetic, Toiletry and Fragrance Association, Inc., Washington, 1995), and the formulation of the external application for skin. Reference may be made to the content disclosed in Remington's Pharmaceutical Science, Mack Publishing Company, Easton PA.

Specifically, the cosmetic composition can be prepared in general emulsified formulations and solubilized formulations. For example, lotion, such as a softening lotion or a nourishing lotion; emulsions such as facial lotions and body lotions; creams such as nourishing creams, moisturizing creams, and eye creams; essence; makeup ointment; spray; gel; pack; sunscreen; makeup base; foundations such as liquid type, solid type or spray type; powder; makeup removers such as cleansing cream, cleansing lotion, and cleansing oil; Alternatively, it may be formulated as a cleaning agent such as a cleansing foam, soap, body wash, but is not limited thereto.

In the cosmetic composition and the composition for external application for skin, in each formulation, other components may be appropriately blended within the range that does not impair the purpose according to the present invention, depending on the type of formulation or purpose of use, in addition to the above essential components.

The cosmetic composition and the composition for external application for skin may include a conventionally acceptable carrier, for example, oil, water, surfactant, humectant, lower alcohol, thickener, chelating agent, pigment, preservative, fragrance, etc. may be appropriately blended, However, the present invention is not limited thereto.

The acceptable carrier may vary depending on the formulation. For example, when formulated into an ointment, paste, cream or gel, animal oil, vegetable oil, wax, paraffin, starch, tracanth, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc, zinc oxide or their Mixtures may be used.

When the cosmetic composition and the composition for external application for skin are formulated as a powder or spray, lactose, talc, silica, aluminum hydroxide, calcium silicate, polyamide powder, or mixtures thereof may be used as a carrier component, and in the case of a spray It may further comprise a propellant such as chlorofluorohydrocarbon, propane, butane or dimethyl ether.

When the cosmetic composition and the composition for external application for skin are formulated as a solution or emulsion, a solvent, solubilizer, or emulsifier may be used as a carrier component, for example, water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl benzoate. , propylene glycol, 1,3-butylglycol oil can be used, in particular cottonseed oil, peanut oil, corn germ oil, olive oil, castor oil and sesame oil, glycerol fatty esters, fatty acid esters of polyethylene glycol or sorbitan can be used

When the cosmetic composition and the composition for external application for skin are formulated as a suspension, a liquid diluent such as water, ethanol or propylene glycol, ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester, and polyoxyethylene sorbitan ester as a carrier component; The same suspending agent, microcrystalline cellulose, aluminum metahydroxide, bentonite, agar or tracanth and the like can be used.

When the cosmetic composition and the composition for external application for skin are formulated into soap, alkali metal salts of fatty acids, fatty acid hemiester salts, fatty acid protein hydrolysates, isethionate, lanolin derivatives, fatty alcohols, vegetable oils, glycerol as carrier components , sugar, etc. may be used.

The cosmetic composition and the composition for external application for skin include fatty substances, organic solvents, solubilizers, thickeners, gelling agents, emollients, antioxidants, suspending agents, stabilizers, and foaming agents commonly used in the industry depending on the quality or function of the final product. agent), fragrance, surfactant, water, ionic or nonionic emulsifier, filler, sequestering agent, chelating agent, preservative, blocking agent, wetting agent, essential oil, dye, pigment, hydrophilic or lipophilic active agent, cosmetic It may additionally contain adjuvants commonly used in the field of cosmetology or dermatology, such as any other ingredients commonly used.

However, the adjuvant and its mixing ratio may be appropriately selected so as not to affect the desirable properties of the cosmetic composition according to the present invention.

Through the following examples, the present invention will be described in more detail, but it is obvious that the present invention is not limited by the following examples.

Examples and Comparative Examples

In order to verify the UV blocking effect of the UV blocker of the present invention, samples were mixed as shown in Table 1 below to set Examples and Comparative Examples.

Each sample was obtained from the market and used, and for the natural extract, a powdered hot water extract was used.

[Content (parts by weight)] division Example comparative example One 2 3 4 One 2 3 4 5 6 7 8 DHHB 60 40 40 30 120 - - - 60 60 40 - Rigida pine extract 60 40 40 30 - 120 - - - - - 40 blackberry extract - 40 - 30 - - 120 - 60 - 40 40 blueberry extract - - 40 30 - - - 120 - 60 40 40

Experimental Example 1: Evaluation of UV protection performance

The UV protection performance of the cosmetic compositions formulated with the samples of Examples and Comparative Examples was evaluated.

The UV blocking efficacy was evaluated by SPF (Sun Protection Factor), which is an index showing the UVB blocking effect, and PFA (Protection Factor of UVA), which is an index showing the UVA blocking effect.

Using Labsphere's UV Transmittance analyzer UV-2000S machine, according to the method provided in the manual, 2 mg/cm ² of each composition was spread on a polymethyl methacrylate (PMMA, 'HELIO PLATE HD6') plate. Blocking indices were determined (Table 2).

Both SPF and PFA were measured three times, and the average value was calculated.

division SPF PFA Example 1 32.5 6.5 Example 2 38.4 8.1 Example 3 37.3 8.3 Example 4 42.5 9.3 Comparative Example 1 18.4 4.5 Comparative Example 2 12.6 1.2 Comparative Example 3 10.6 2.1 Comparative Example 4 15.3 1.9 Comparative Example 5 20.4 4.3 Comparative Example 6 18.2 4.7 Comparative Example 7 21.4 5.1 Comparative Example 8 19.2 2.5

Referring to Table 2, when DHHB was applied simultaneously with the Rigida pine extract (Examples 1 to 4), the UV blocking effect was significantly improved, and the sample of Comparative Example that does not include it at the same time had a relatively low level of UV blocking activity. became

The above results suggest that synergistic activity can be realized by acting simultaneously with DHHB and Rigida pine extract.

In particular, in the samples of Examples (Examples 3 and 4), the UV blocking effect was further enhanced by the blackberry extract and the blueberry extract.

Experimental Example 2: UV-Vis analysis

UVA and UVB absorption spectra of the samples of Examples and Comparative Examples were measured ( FIG. 1 ).

At this time, the absorption spectra of UVA and UVB were measured using a spectrophotometer (Agilent Technologies, Cary 8454).

Absorption unit (AU) at a wavelength of 300 nanometers in the UVB region and the absorption rate at a wavelength of 360 nm in the UVA region were calculated (Table 3).

division AU (300 nm) AU (360 nm) Example 1 2.82 2.13 Example 2 3.36 2.69 Example 3 3.48 2.53 Example 4 3.63 2.97 Comparative Example 1 1.40 1.53 Comparative Example 2 1.29 1.40 Comparative Example 3 0.83 1.54 Comparative Example 4 1.26 1.23 Comparative Example 5 1.28 1.28 Comparative Example 6 1.53 1.85 Comparative Example 7 1.42 1.72 Comparative Example 8 1.28 1.47

Referring to Table 3, when DHHB was simultaneously applied with the Rigida pine extract (Examples 1 to 4), the UV absorption rate was significantly improved, and the sample of Comparative Example not including it at the same time had a relatively low UV absorption rate.

The above results suggest that DHHB and Rigida pine extract may exhibit synergistic activity by acting simultaneously.

In particular, in the samples of Examples (Examples 3 and 4), the UV absorption rate and UV absorption rate were further improved by the blackberry extract and the blueberry extract.

The sunscreen composition of the present invention not only has excellent UV protection activity, but also can significantly improve UV protection performance by synergistic activity with natural extracts. It can significantly reduce irritation.

The foregoing description of the present invention is for illustration, and those of ordinary skill in the art to which the present invention pertains can understand that it can be easily modified into other specific forms without changing the technical spirit or essential features of the present invention. will be. Therefore, it should be understood that the embodiments described above are illustrative in all respects and not restrictive. For example, each component described as a single type may be implemented in a distributed manner, and likewise components described as distributed may also be implemented in a combined form.

The scope of the present invention is indicated by the following claims, and all changes or modifications derived from the meaning and scope of the claims and their equivalents should be construed as being included in the scope of the present invention.

Claims (8)

A sunscreen composition comprising DHHB (Diethylamino Hydroxy benzoyl HexylBenzoate) and Rigida pine extract as active ingredients. The method of claim 1,
A sunscreen composition further comprising blackberry extract. 3. The method of claim 2,
A sunscreen composition further comprising a blueberry extract. A sunscreen composition having blocking activity against UVA and UVB. A cosmetic composition comprising the composition of any one of claims 1 to 4 6. The method of claim 5,
From the group consisting of softening lotion, nourishing lotion, moisture cream, nourishing cream, massage cream, nourishing lotion, essence, ampoule, gel, eye cream, oil, foundation, cleansing cream, cleansing foam, cleansing water, mask pack, spray and powder A cosmetic composition formulated with one or more selected. A composition for external application to the skin comprising the composition of any one of claims 1 to 4. 8. The method of claim 7,
Creams, gels, patches, sprays, ointments, warning agents, lotions, liniment agents, pasta agents and cataplasma agents, formulated with one or more selected from the group consisting of, external composition for skin.