JP4933768B2 - Anti-dermatological agent and external preparation for skin containing the same - Google Patents

Description

  The present invention relates to an anti-dermatological agent that suppresses or ameliorates skin damage caused by exposure to ultraviolet rays, and an external preparation for skin containing the same. More specifically, an anti-dermatological agent containing a polar solvent extract of Hippophae rhamnoides L. as an active ingredient, and a polar solvent extract of Hippophae rhamnoides L. As an anti-dermatological agent, as a cosmetic or pharmaceutical agent that suppresses or improves at least one of abnormal accumulation of skin extracellular matrix components caused by UV exposure, collagen cross-linking, wrinkle formation, skin thickening, skin hardening, etc. The present invention relates to a useful external preparation for skin.

Long-term exposure to ultraviolet rays (e.g. sunlight) causes skin to become irritated by chemical mediators, cytokines, etc., and skin disorders such as wrinkles, talmi, skin thickening, skin sclerosis, skin cancer, solar elastic fibrosis, etc. (See Non-Patent Document 1). In particular, thickening of the epidermis and dermis results in a decrease in skin elasticity and moisture retention, which is considered to be one of the causes of skin aging. Therefore, in order to prevent these obstacles conventionally, an external preparation containing an ultraviolet absorber (see Patent Document 1 and Non-Patent Document 2) and an ultraviolet scattering agent (see Non-Patent Document 3), that is, an emulsion, cream, lotion, Cosmetic liquids, foundations, ointments, cataplasms, patches, etc. are used. In addition, retinoic acid (see Non-Patent Document 4), anti-inflammatory drug (see Non-Patent Document 5) in order to prevent or improve skin wrinkles, tarmi, elasticity and reduced elasticity caused by exposure to ultraviolet rays, etc. ), Buckwheat extract, birch extract, sage extract, roman chamomile extract, etc. (see Patent Document 2), Melissa extract (see Patent Document 3), and also active in inhibiting abnormal accumulation of extracellular matrix components, skin thickening, wrinkles, etc. Formulation of type vitamin D ₃ (see Non-Patent Document 6) has been reported.

However, for example, a topical skin preparation formulated with retinoic acid has an effect of improving the wrinkle by proliferating collagen in the upper layer of the dermis, but the effect of suppressing the generation of wrinkles is not recognized. There is a problem such as returning. The active vitamin D ₃ have a side effect problems such as calcium metabolism. Even in the topical skin preparations containing other UV absorbers, UV scattering agents, anti-inflammatory agents, plant extracts, etc., these are not effective in suppressing or improving wrinkle formation, skin thickening, etc. When these additives are blended at a high concentration, the usability of the preparation may be impaired, and problems such as deterioration at high temperatures and over time may occur.

  On the other hand, the application of Sashimi to cosmetics is a whitening effect by using a combination of Sashiki fruit oil and seed oil-containing cosmetics having an anti-aging effect on skin (see Patent Document 4) and Sashiki fruit oil and herbal extract components. There are cosmetics having moisturizing action, skin elasticity maintaining action, anti-aging, and ultraviolet absorption action (see Patent Document 5), but it contains a polar solvent extract of spinach to suppress skin damage caused by UV exposure or There are no cosmetics that have an improving effect.

JP 09-268194 A Japanese Patent Application Laid-Open No. 08-109122 JP 09-241148 A JP 63-145210 A JP 2004-123563 A Tsutomu Sugawara and Keiichi Nozu, “Solar UV and Health,” Yukabo (1998) p. 2-100 Nicholas J. Rowe / Nadim A. Germ, “Sunscreen and Dermatology”, published on May 20, 1993, Fragrance Journal, P.A. 195-262 “Fragrance Journal”, Fragrance Journal, July 2002 16-27, 33-38 Lorraine H. Kligman, “Effects of all-trans-retinoic acid on the dermis of hairless rice,” Journal of the American Academy of Dermatology, 1988. 15, no. 4, Part. 2, October, P.M. 779-785 Bissett DL, et al. Author, “Photoprotective effect of topical anti-inflammatory agents against ultraradiation radiation-induced chronic skin damage in the hair 90.” 7, p. 153-158 Koshiishi I, et al. “1,25-dihydroxyvitamin D3 presents the conversion of adipose tissue into fibrosstic in inspired to chronic UV iradiation.”, Toyco. 173, P.I. 99-104

  Accordingly, an anti-dermatological agent that effectively suppresses or ameliorates at least one skin disorder such as abnormal accumulation of extracellular matrix components, collagen cross-linking formation, wrinkle formation, skin thickening, and skin hardening caused by ultraviolet exposure, and There has been a demand for the development of an external preparation for skin containing this without adversely affecting the feeling of use and dosage form.

  In order to achieve the above-mentioned object, the present inventors have focused on ingredients used in pharmaceuticals, cosmetic raw materials, folk medicines and the like that have already been confirmed to be safe. The polar solvent extract of Hippophae rhamnoides L. is at least one of abnormal accumulation of extracellular matrix components, collagen cross-linking, wrinkle formation, skin thickening, skin hardening, etc. caused by UV exposure The present invention was completed by obtaining new knowledge that it is excellent in the effect of suppressing or improving the occurrence of skin disorders.

  That is, the present invention relates to an anti-dermatological agent that suppresses or ameliorates skin damage caused by exposure to ultraviolet rays, which comprises a polar solvent extract of Hippophae rhamnoides L. as an active ingredient. Moreover, the skin disorder | damage | failure resulting from an ultraviolet-ray exposure is related with the anti-dermatological agent which is at least 1 or more of abnormal accumulation | storage of a skin extracellular matrix component, collagen cross-linking formation, wrinkle formation, skin thickening, and skin hardening. Still further, the present invention relates to an external preparation for skin containing the anti-dermatological agent as an active ingredient and suppressing or improving the above-mentioned skin damage, particularly to an external preparation for preventing aging.

  Polar solvent extract of Hippophae rhamnoides L. in accordance with the present invention is an abnormal accumulation of skin extracellular matrix components and collagen cross-linking formation, wrinkle formation, skin thickening, and skin hardening caused by UV exposure. It is an anti-dermatological agent highly effective in suppressing or improving at least one skin disorder. The topical skin preparation containing the anti-dermatological agent as an active ingredient effectively suppresses or ameliorates the skin disorder caused by exposure to ultraviolet rays. Therefore, a cosmetic or quasi-drug that prevents skin aging. Etc., which can be used advantageously.

Hereinafter, the present invention will be described in detail.
A polar solvent extract of Hippophae rhamnoides L. (hereinafter referred to as a scientific name in Latin and a Japanese family, a genus is omitted, simply abbreviated as Spine) used in the present invention It is extracted using. The extraction site is not particularly limited, but can be extracted from any one or more of whole grass or root, stem, stem, bark, bud, leaf, flower, fruit, seed, etc. A method of extracting these with a polar solvent at a low temperature or from room temperature to warming after appropriate treatment such as drying, chopping, pressing or fermentation can be mentioned.

  Examples of the extraction solvent used in the present invention include polar solvents such as water, alcohol and polyhydric alcohol in order to remove oil and fat components, and one or more of these can be used. Particularly preferred extraction solvents include water or water-ethyl alcohol mixed polar solvents.

  Further, this polar solvent extract can be used in any of molecular weight fractionation, solvent fractionation, purified by various resin treatments (ion exchange resin, adsorbent, etc.), freeze-dried, etc. .

  As a specific manufacturing method, for example, dried dried spinach fruit is crushed, using about 10 times the concentration of hydrous ethyl alcohol having a concentration of 0 to 100 vol% or hydrous 1,3-butylene glycol, at room temperature or by heating. After extraction for 1-2 hours, add celite (diatomaceous earth) to completely remove the oil and fat components, filter, and extract the molecular weight fraction, solvent fraction, various resin treatments (ion exchange resin, adsorption) And the like, and freeze-dried to obtain a polar solvent extract of spinach. In the case of a water-ethyl alcohol solvent, ethyl alcohol is distilled off and then lyophilized to obtain a polar spinach extract.

  The form of the anti-dermatological agent of the present invention is not particularly limited as long as it is included as a polar solvent extract of sagittal, and can be used in any form such as liquid, paste, cream, gel, and powder. .

  Moreover, the external preparation for skin of the present invention is characterized by containing a polar solvent extract of spinach as an anti-dermatological agent. The content of the anti-dermatological agent in the external preparation for skin of the present invention is not particularly limited, but 0.0001 to 10% by mass (hereinafter simply referred to as “%”) as the polar solvent extract of sagittal in the external preparation for skin. ", Preferably 0.001 to 5%, more preferably 0.1 to 3%. Within this range, abnormal accumulation of extracellular matrix components due to UV exposure, especially abnormal production of collagen and collagen cross-linking, as well as the development of at least one skin disorder such as wrinkle formation, skin thickening, skin hardening, etc. It is excellent in the effect of suppressing or improving the symptom thereof, and good in terms of stability over time can be obtained.

  In addition to the above essential components, the external preparation for skin containing the anti-dermatological agent of the present invention includes various components usually used in cosmetics, quasi-drugs, external medicines, that is, water, alcohols, oils, interfaces. Active agents, thickeners, powders, chelating agents, pH adjusters, whitening agents, anti-inflammatory agents, antioxidants, moisturizers, bactericides, blood circulation promoters and other medicinal agents, extracts derived from animals, plants and microorganisms In addition, an ultraviolet absorber, an ultraviolet scattering agent, a fragrance and the like can be appropriately added depending on the purpose within a range not impairing the effects of the present invention.

  Examples of the external preparation for skin containing the anti-dermatological agent of the present invention include cosmetics, quasi-drugs, pharmaceuticals, etc., and the dosage form is an aqueous dosage form, an oil-based dosage form, an emulsifier type, a powder dosage form, It can mix | blend with any dosage forms, such as a solid dosage form. For example, as cosmetics, it can be used in lotions, milky lotions, creams, cosmetic liquids, packs, bath salt ointments, gels, foundations, powders, lip balms, lipsticks, sunscreen products, and the like.

  Next, the present invention will be described in more detail with reference to production examples and examples of polar solvent extract of sashiko, but the present invention is not limited thereto.

Production examples 1 to 4 of the polar solvent extract of Sakashi are shown in Production Examples 1 to 4, and examples of production of birch bark extract (used in evaluation tests as a positive control) for which anti-wrinkle action has already been reported are shown in Production Example 5.
[Production Example 1]
1,000 mL of water was added to 100 g of crushed dried spruce fruit, and hot water extraction was performed for 1 hour. After cooling, add 10% Celite to this volume, pressurize and filter, use membrane separation to collect 5,000 or less molecular weight, obtain 600 mL of extract, concentrate under reduced pressure with an evaporator, Freeze-dried to obtain 16.3 g of a polar solvent extract of spinach.

[Production Example 2]
1,000 mL of a 25 vol% ethanol aqueous solution was added to 100 g of the crushed dried spruce fruit, and reflux extraction was performed for 2 hours. Celite 10% was added to this volume, filtered under pressure, and membrane separation was used to collect a sample having a molecular weight of 5,000 or less, to obtain 650 mL of an extract, concentrated under reduced pressure with an evaporator, and ethanol was distilled off. This solution was freeze-dried to obtain 18.4 g of a polar solvent extract of sagittal.

[Production Example 3]
1,000 mL of a 50 vol% aqueous ethanol solution was added to 100 g of dried crushed spinach fruit, and reflux extraction was performed for 2 hours. This was filtered and concentrated under reduced pressure with an evaporator. After distilling off ethanol, 400 mL of water was added, 10% of Celite was added to the volume, filtered, and a membrane having a molecular weight of 5,000 or less was collected using membrane separation. , 740 mL of an extract was obtained, and this solution was lyophilized to obtain 13.8 g of a polar solvent extract of sagittal.

[Production Example 4]
1,000 mL of 25 vol% ethanol aqueous solution was added to 100 g of the crushed dried spiny bark and reflux extraction was performed for 2 hours. Celite 10% was added to this volume, filtered under pressure, and membrane separation was used to collect a sample having a molecular weight of 5,000 or less, to obtain 650 mL of an extract, concentrated under reduced pressure with an evaporator, and ethanol was distilled off. This solution was freeze-dried to obtain 8.2 g of a polar spinach solvent extract.

[Production Example 5]
1,000 mL of 25 vol% ethanol aqueous solution was added to 100 g of crushed birch bark dry matter, and reflux extraction was performed for 2 hours. Centrifugation, pressure filtration, and membrane separation were used to collect a sample having a molecular weight of 5,000 or less, and 660 mL of an extract was obtained and concentrated under reduced pressure using an evaporator. After distilling off ethanol, this solution was freeze-dried. 7.4 g of birch bark extract was obtained.

Example 1: Skin damage test by hairless mouse UV irradiation Anti-skin damage preparation was prepared by the following preparation method, skin thickening due to UV irradiation, wrinkle formation, skin hardening, abnormal accumulation of skin extracellular matrix components (total hydroxyproline amount, Dermatan sulfate amount) and collagen crosslink formation (pepsin resistant hydroxyproline).

[Preparation of sample (anti-dermatological preparation)]
A spinach polar solvent extract of Production Examples 1 to 3 and a birch bark extract of Production Example 5 were dissolved in a base (polyethylene glycol 1000: ethyl alcohol = 1: 1) to prepare a sample at a concentration of 5%, and hairless mass It was used for the skin evaluation test by the ultraviolet irradiation of the mouse. The birch bark extract was used as a positive control.

[Sample application method and UV irradiation method]
One group consists of 8 animals, and 0.1 g of the above sample is applied to the back of hairless mice (10 weeks old) 90 minutes before UV irradiation, and a certain amount of UV light (Toshiba FL20S / BLB lamp) is applied for 2 hours a day (5 times). / Week) Irradiation was carried out for 20 weeks (total irradiation amount: 720 J / cm ² ), and skin thickening, wrinkle formation, and skin hardening inhibitory effects were examined.
In addition, the ultraviolet absorption spectrum of these samples was measured, and it was confirmed that these did not affect the evaluation test.

[Evaluation method]
(Skin thickening suppression effect)
The thickness of the skin before ultraviolet irradiation and 20 weeks after ultraviolet irradiation was measured using a dial thickness gauge (OZAK.MFG.CO.LTD.). The results were evaluated by the average value of the skin thickness of 8 animals and the rate of increase after 20 weeks.

(Wrinkle formation inhibitory effect)
About wrinkle formation 20 weeks after ultraviolet irradiation, the wrinkle grade was determined based on the “photoskin aging grade” shown in Table 4 below. In addition, the result was expressed and evaluated as an average value of 8 scores.

(Skin hardening inhibitory effect)
The central part of the back of the hairless mouse skin was picked, and the skin requiring 5 seconds or more for restoration was regarded as skin hardening, and the expression rate in 8 mice was evaluated.

[Abnormal accumulation of extracellular matrix components; total hydroxyproline content, dermatan sulfate content]
(Total hydroxyproline; collagen determination method)
Hydroxyproline in the skin was measured and the amount of abnormal collagen accumulation was evaluated.
For the determination of hydroxyproline, first, a frozen section (20 microns) of hairless mouse dorsal skin was prepared, and the skin section was heat-treated on a slide glass, and then 0.05% alkaline protease (actinase E; manufactured by Kaken Pharmaceutical) (500 tyrosinase) (Unit / mL) was enzymatically degraded (40 ° C.-2 hours) and solubilized in this enzyme solution. Thereafter, the sample was vacuum-sealed, hydrolyzed with 6N hydrochloric acid (145 ° C. for 4 hours), and then hydroxyproline was colored by the Woessner method and measured.

(Dermatan sulfate determination method)
Like collagen, abnormal accumulation of dermatan sulfate, an extracellular matrix component, is one of the indicators of skin aging caused by ultraviolet irradiation, and the degree of skin aging was evaluated by measuring this component. After formalin fixation of the hairless mouse dorsal skin, a 6-micron skin section is prepared, and the skin section is mixed with chondroitinase ABC (0.5 units / mL) and collagenase (500 mandel units / mL) on a slide glass. After enzymatic degradation with the solution (37 ° C. for 2 hours) and solubilization in this enzyme solution, the sample was separated using an HPLC apparatus by the post-column method under the following conditions, mixed with the reaction reagent 1, and then After mixing with the reaction reagent 2, it was reacted in a tube at 110 ° C. for 2 minutes to obtain a fluorescent derivative, which was measured with a fluorescence detector.

(HPLC conditions)
HPLC column: DOCOSIL (4.6id × 150mm: manufactured by Senshu Scientific Co., Ltd.)
Fluorescence detection: Ex. 346 nm, Em. 410nm
Mobile phase: 8.5% acetonitrile-1 mM tetra n-butylammonium hydrogensulfate Flow rate: 1.5 mL / min Column temperature: 60 ° C.
Reaction reagent 1: 0.3 M NaOH (0.25 mL / min)
Reaction reagent 2: 0.25% 2-cyanoacetamide

(Collagen cross-linking: Pepsin resistant hydroxyproline assay)
The degree of collagen cross-linking in the skin was evaluated based on the difficulty of degradation by acid protease (pepsin; manufactured by Nacalai Tesque).
First, a frozen section (20 microns) of the hairless mouse dorsal skin prepared by the above-described collagen quantification method was enzymatically degraded with 0.01% pepsin (366 units / mL) on a slide glass (5 ° C.-64 hours) to allow pepsin. The dissolved collagen was removed by washing with water. Thereafter, pepsin-resistant collagen was heated by the same method as described above, and then enzymatically decomposed using actinase E and solubilized in this enzyme solution. Next, the solution was sealed in a vacuum, hydrolyzed with 6N hydrochloric acid (145 ° C. for 4 hours), and then developed with hydroxyproline by Woessener method to measure pepsin resistant hydroxyproline.

(Pepsin resistant hydroxyproline (%) calculation method)
The content of pepsin resistant hydroxyproline relative to total hydroxyproline in the skin was calculated and used as an index for collagen cross-linking formation.
Pepsin resistant hydroxyproline content (%) = (pepsin resistant hydroxyproline / total hydroxyproline) × 100

Tables 1 to 3 show the evaluation results of skin thickening, wrinkle formation, skin hardening, abnormal accumulation of extracellular matrix components (total hydroxyproline amount, dermatan sulfate amount), and collagen cross-linking formation (pepsin resistant hydroxyproline amount, content), respectively. Also shown.

As is apparent from Tables 1 to 3, the polar solvent extract of the spines of Examples 1 to 3 of the present invention was compared with the birch bark extract, which was a positive control, and all showed significant skin thickening, skin hardening, and wrinkle formation. It was extremely excellent in the effect of suppressing abnormal accumulation of extracellular matrix components and collagen crosslinking.

Example 2 Cream (ingredient) (%)
(1) Monostearic acid polyethylene glycol (40E.O.) 2.0
(2) Self-emulsifying glyceryl monostearate 5.0
(3) Stearic acid 5.0
(4) Behenyl alcohol 1.0
(5) Liquid paraffin 10.0
(6) Glyceryl trioctanoate 10.0
(7) Shashiko polar solvent extract * 1 5.0
(8) Glycerin 5.0
(9) Preservative appropriate amount (10) perfume appropriate amount (11) remaining amount of purified water * 1 Production Example 1

(Manufacturing method)
A. Ingredients (1)-(6) are mixed and heated to keep at 70 ° C.
B. Ingredients (8) and (11) are mixed and heated to maintain 70 ° C.
C. B is added to A and emulsified.
D. After adding components (7), (9), and (10) to C, the mixture was cooled to obtain a cream.

  Example 2 is stable without discoloration and odor, and when applied to the skin, it has a smooth spread and high emollient feeling, and when applied continuously, the skin such as wrinkle formation by ultraviolet rays, skin thickening, skin hardening, etc. It was excellent in the effect of suppressing or improving the obstacle.

Example 3 lotion (ingredient) (%)
(1) Glycerin 10.0
(2) 1,3-butylene glycol 6.0
(3) Citric acid 0.1
(4) Sodium citrate 0.3
(5) Shashiko polar solvent extract * 1 2.0
(6) Purified water remaining amount (7) polyoxyethylene hydrogenated castor oil (60 EO) 0.5
(8) Ethyl alcohol 8.0
(9) Preservative appropriate amount (10) Fragrance appropriate amount * 1 Production Example 2

(Manufacturing method)
A. Components (1) to (6) are mixed and dissolved.
B. Components (7) to (10) are mixed and dissolved.
C. A and B were mixed and made uniform to obtain a skin lotion.

  Example 3 is stable without discoloration, odor, precipitation, etc., and when applied to the skin, it has a fresh spread and moisturizing feeling, and when applied continuously, the skin such as wrinkle formation by ultraviolet rays, skin thickening, skin hardening, etc. It was effective in suppressing or improving the obstacle.

Example 4 Latex (component) (%)
(1) Sorbitan monostearate 0.3
(2) Polyoxyethylene sorbitan monooleate (20E.O.) 0.1
(3) Lipophilic glyceryl monostearate 0.2
(4) Stearic acid 0.5
(5) Cetanol 0.5
(6) Squalane 3.0
(7) Liquid paraffin 4.0
(8) Glyceryl tri-2-ethylhexanoate 2.0
(9) Dimethylpolysiloxane 1.0
(10) Hydrogenated soybean phospholipid 0.1
(11) Carboxyvinyl polymer aqueous solution (1.0%) 10.0
(12) Sodium hydroxide 0.05
(13) Glycerin 5.0
(14) 1,3-butylene glycol 7.0
(15) Purified water Residual amount (16) Shashiko polar solvent extract * 1 1.0
(17) Ethyl alcohol 5.0
(18) Silicic anhydride 1.0
(19) Preservative appropriate amount (20) Fragrance appropriate amount * 1 Production Example 3

(Manufacturing method)
A. Ingredients (1) to (10) are heated and mixed and maintained at 70 ° C.
B. Ingredients (11) to (15) are heated and mixed and maintained at 70 ° C.
C. Add B to A, mix and uniformly emulsify.
D. After cooling C, (16) and (17) to (20) were added and mixed uniformly to obtain an emulsion.

  Example 4 is stable without discoloration, odor, separation, and the like, and when applied to the skin, it has a smooth stretch and spread, has a high moisturizing feeling, and is continuously applied to form wrinkles due to ultraviolet rays, skin thickening, skin It was effective in suppressing or improving skin disorders such as curing.

Example 5 Pack (ingredient) (%)
(1) Polyvinyl alcohol 15.0
(2) Silicic anhydride 0.5
(3) Polyethylene glycol 0.5
(4) Polyoxypropylene methyl glucoside 5.0
(5) Glycerin 5.0
(6) Purified water remaining amount (7) Ethyl alcohol 10.0
(8) Preservative appropriate amount (9) Shashiko polar solvent extract * 1 0.2
(10) Perfume appropriate amount * 1 Production Example 4

(Manufacturing method)
A. Components (1) to (6) are mixed and heated to 70 ° C. to dissolve.
B. Components (7) to (8) are mixed and dissolved.
C. B was added to the previous A, mixed, and then cooled to uniformly disperse (9) and (10) to obtain a pack.

  Example 5 is stable without discoloration, odor, separation, etc. When applied to the skin, there is a moderate tension, the skin after peeling off is highly moist, wrinkle formation by ultraviolet rays, skin thickening It was excellent in the effect of suppressing or reducing skin disorders such as skin hardening.

Example 6 Liquid foundation (component) (%)
(1) Dipentaerythritol tetra-12 hydroxystearic acid sesquistearic acid hemirosin ester 2.0
(2) Liquid paraffin 5.0
(3) Stearic acid 2.0
(4) Cetanol 1.0
(5) Self-emulsifying glyceryl monostearate 1.0
(6) Paramethoxycinnamic acid-2-ethylhexyl 8.0
(7) Shashiko polar solvent extract * 1 0.1
(8) Preservative appropriate amount (9) Glycerin 5.0
(10) Triethanolamine 1.0
(11) Carboxymethylcellulose 0.2
(12) Bentonite 0.5
(13) Purified water remaining amount (14) Titanium oxide 6.0
(15) Fine particle titanium oxide 2.0
(16) Fine zinc oxide 5.0
(17) Mica 2.0
(18) Talc 4.0
(19) Color pigment 4.0
(20) Perfume appropriate amount * 1 Production Example 1

(Manufacturing method)
A. Components (1) to (6) are heated and mixed and dissolved.
B. Ingredients (14) to (19) are added to A, mixed uniformly, and kept at 70 ° C.
C. Ingredients (8) to (13) are uniformly dissolved and kept at 70 ° C.
D. B is added to C and emulsified uniformly.
E. After cooling D, components (7) and (20) were added to obtain a liquid foundation.

  Example 6 is stable with no odor, separation, etc., and when applied to the skin, is excellent in moisturizing makeup effect, protects the skin moderately from ultraviolet rays in the daytime, wrinkles due to ultraviolet rays, skin thickening, skin It was excellent in the effect of suppressing or reducing skin disorders such as curing.

Example 7 Sunscreen Latex (Component) (%)
(1) Polyoxyethylene / methylpolysiloxane copolymer 1.0
(2) Dimethylpolysiloxane 5.0
(3) Octamethylcyclotetrasiloxane 20.0
(4) Isotridecyl isononanoate 5.0
(5) Paramethoxycinnamic acid-2-ethylhexyl 5.0
(6) Fine particle titanium oxide 10.0
(7) Fine zinc oxide 10.0
(8) Zirconium oxide 5.0
(9) Polystyrene powder 3.0
(10) Trimethylsiloxysilicate 0.5
(11) Preservative appropriate amount (12) Dipropylene glycol 3.0
(13) Ethyl alcohol 10.0
(14) Purified water remaining amount (15) Salt 0.2
(16) Shashiko polar solvent extract * 1 0.2
(17) Perfume appropriate amount * 1 Production Example 3

(Manufacturing method)
A. Components (1) to (10) are mixed and dispersed.
B. Components (11) to (15) are mixed and dissolved.
C. Add B to A and emulsify uniformly.
D. Components (16) and (17) were added to C to obtain a sunscreen emulsion.

  Example 7 is stable without odor and separation, and has a refreshing emollient feeling when applied to the skin, protects the skin from ultraviolet rays during the day, and forms wrinkles, thickened skin, and cured skin by ultraviolet rays. It was excellent in the effect of suppressing or reducing the obstacle.

Claims (4)

Due to ultraviolet exposure, polar solvent extract obtained by crushing Hippophae rhamnoides L., extracting with polar solvent, then adding Celite (registered trademark) and filtering is the active ingredient An anti-dermatological agent characterized by suppressing or improving skin disorders. The anti-skin according to claim 1, wherein the skin damage caused by exposure to ultraviolet rays is at least one of abnormal accumulation of skin extracellular matrix components, collagen cross-linking formation, wrinkle formation, skin thickening, and skin hardening. Disability agent. A skin external preparation comprising the anti-dermatological agent according to claim 1 as an active ingredient. The skin external preparation according to claim 3, wherein the skin external preparation is for anti-aging.