KR20220140027A - 신경교종을 포함하는 암을 치료하기 위해 에플로르니틴 및 이의 유도체 및 동족체를 사용하기 위한 조성물 및 방법 - Google Patents

신경교종을 포함하는 암을 치료하기 위해 에플로르니틴 및 이의 유도체 및 동족체를 사용하기 위한 조성물 및 방법 Download PDF

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Publication number
KR20220140027A
KR20220140027A KR1020227034401A KR20227034401A KR20220140027A KR 20220140027 A KR20220140027 A KR 20220140027A KR 1020227034401 A KR1020227034401 A KR 1020227034401A KR 20227034401 A KR20227034401 A KR 20227034401A KR 20220140027 A KR20220140027 A KR 20220140027A
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KR
South Korea
Prior art keywords
eflornithine
derivative
group
glioma
composition
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KR1020227034401A
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English (en)
Korean (ko)
Inventor
빅터 에이. 레빈
Original Assignee
오버스 쎄라퓨틱스, 인코포레이티드
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Publication of KR20220140027A publication Critical patent/KR20220140027A/ko

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/17Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/17Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A61K31/175Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine having the group, >N—C(O)—N=N— or, e.g. carbonohydrazides, carbazones, semicarbazides, semicarbazones; Thioanalogues thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/475Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
KR1020227034401A 2016-03-24 2017-03-16 신경교종을 포함하는 암을 치료하기 위해 에플로르니틴 및 이의 유도체 및 동족체를 사용하기 위한 조성물 및 방법 KR20220140027A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662312623P 2016-03-24 2016-03-24
US62/312,623 2016-03-24
KR1020187030685A KR102452370B1 (ko) 2016-03-24 2017-03-16 신경교종을 포함하는 암을 치료하기 위해 에플로르니틴 및 이의 유도체 및 동족체를 사용하기 위한 조성물 및 방법
PCT/US2017/022718 WO2017165187A1 (fr) 2016-03-24 2017-03-16 Compositions et méthodes pour l'utilisation d'éflornithine et de dérivés et analogues de cette dernière pour le traitement de cancers, dont les gliomes

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020187030685A Division KR102452370B1 (ko) 2016-03-24 2017-03-16 신경교종을 포함하는 암을 치료하기 위해 에플로르니틴 및 이의 유도체 및 동족체를 사용하기 위한 조성물 및 방법

Publications (1)

Publication Number Publication Date
KR20220140027A true KR20220140027A (ko) 2022-10-17

Family

ID=59896896

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020227034401A KR20220140027A (ko) 2016-03-24 2017-03-16 신경교종을 포함하는 암을 치료하기 위해 에플로르니틴 및 이의 유도체 및 동족체를 사용하기 위한 조성물 및 방법
KR1020187030685A KR102452370B1 (ko) 2016-03-24 2017-03-16 신경교종을 포함하는 암을 치료하기 위해 에플로르니틴 및 이의 유도체 및 동족체를 사용하기 위한 조성물 및 방법

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020187030685A KR102452370B1 (ko) 2016-03-24 2017-03-16 신경교종을 포함하는 암을 치료하기 위해 에플로르니틴 및 이의 유도체 및 동족체를 사용하기 위한 조성물 및 방법

Country Status (13)

Country Link
US (2) US20170273926A1 (fr)
EP (1) EP3432872B1 (fr)
JP (2) JP2019509349A (fr)
KR (2) KR20220140027A (fr)
CN (1) CN109152758A (fr)
AU (2) AU2017236646A1 (fr)
CA (1) CA3018821C (fr)
DK (1) DK3432872T3 (fr)
ES (1) ES2896735T3 (fr)
IL (1) IL261920A (fr)
MX (1) MX2018011536A (fr)
PL (1) PL3432872T3 (fr)
WO (1) WO2017165187A1 (fr)

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US20170273926A1 (en) * 2016-03-24 2017-09-28 Orbus Therapeutics, Inc. Compositions and methods for use of eflornithine and derivatives and analogs thereof to treat cancers, including gliomas
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Hdac抑制劑與pd-l1抑制劑之組合治療
US10786470B2 (en) 2016-10-06 2020-09-29 Orbus Therapeutics, Inc. Formulations for administration of eflornithine
KR20200055722A (ko) * 2017-09-20 2020-05-21 오클라호마 메디컬 리써치 화운데이션 약물 내성 신경아교종의 치료
EP3942023A1 (fr) 2019-03-18 2022-01-26 The Broad Institute, Inc. Compositions et méthodes de modulation de régulateurs métaboliques de pathogénicité de lymphocytes t
CN110646557A (zh) * 2019-10-12 2020-01-03 北京航空航天大学 携带idh基因突变的胶质母细胞瘤患者的尿液代谢标志物及其用途
WO2023235504A2 (fr) * 2022-06-01 2023-12-07 Syncromune, Inc. Méthode de traitement du cancer par lyse de cellules tumorales et administration intratumorale de combinaisons d'ingrédients immunothérapeutiques

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US6949679B1 (en) * 1998-04-21 2005-09-27 Universite Laval Polyamine transport inhibitors
US20030203956A1 (en) 1998-12-23 2003-10-30 Masterrer Jaime L. Method of using a cyclooxygenase-2 inhibitor and one or more ornithine decarboxylase inhibitors as a combination therapy in the treatment of neoplasia
AU2713500A (en) * 1998-12-23 2000-07-31 G.D. Searle & Co. Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
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US6653351B2 (en) * 2001-08-13 2003-11-25 Board Of Regents, The University Of Texas System Adjuvant chemotherapy for anaplastic gliomas
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JP5421374B2 (ja) * 2008-09-03 2014-02-19 ザ・ジョンズ・ホプキンス・ユニバーシティー 悪性神経膠腫におけるイソクエン酸デヒドロゲナーゼ遺伝子および他の遺伝子の遺伝子変化
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Also Published As

Publication number Publication date
IL261920A (en) 2018-10-31
US20190091187A1 (en) 2019-03-28
CN109152758A (zh) 2019-01-04
KR102452370B1 (ko) 2022-10-07
ES2896735T3 (es) 2022-02-25
PL3432872T3 (pl) 2022-01-03
EP3432872B1 (fr) 2021-08-25
WO2017165187A1 (fr) 2017-09-28
AU2023200537A1 (en) 2023-03-02
JP2022095882A (ja) 2022-06-28
EP3432872A1 (fr) 2019-01-30
AU2017236646A1 (en) 2018-11-15
JP2019509349A (ja) 2019-04-04
DK3432872T3 (da) 2021-10-11
CA3018821C (fr) 2023-03-14
MX2018011536A (es) 2019-07-04
KR20180124976A (ko) 2018-11-21
US20170273926A1 (en) 2017-09-28
CA3018821A1 (fr) 2017-09-28
EP3432872A4 (fr) 2019-11-13

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