KR20220138066A - Cosmetic composition for preventing hair loss or promoting hair growth with xanthohumol as the main ingredient - Google Patents

Abstract

The present invention relates to a cosmetic composition for preventing hair loss or promoting hair growth including xanthohumol, which includes xanthohumol contained in 101 bottles of beer (500 ml) in 500 g of a cosmetic composition. The present invention provides excellent usability after using the cosmetic composition.

Description

Cosmetic composition for preventing hair loss or promoting hair growth with xanthohumol as the main ingredient {Cosmetic composition for preventing hair loss or promoting hair growth with xanthohumol as the main ingredient}

The present invention relates to a cosmetic composition for preventing hair loss or promoting hair growth, and to a cosmetic composition containing xanthohumol.

Hair plays a role in protecting the human body from external stimuli, such as protecting the scalp and maintaining body temperature. Hair is generated from hair follicles and has a growth cycle of growth (3 years), regression (3 weeks), and resting (3 months). Hair loss refers to the loss of hair, and it is divided into natural hair loss, in which the hair in the resting phase naturally falls out, and abnormal hair loss in which the hair in the growing phase suddenly enters the resting phase and falls out in large quantities due to febrile disease, pregnancy, mental stress, etc.

Hair growth is usually most active between the ages of 15 and 30, and progressively regresses at the age of 40 to 50, and natural hair loss due to aging begins at the age of 50 or older, and progresses faster after the age of 70. Normally, about 50 to 100 hairs fall out per day and normal catagen hair loss occurs. If hair loss occurs in excess of this, hair loss may be suspected depending on the cause and symptoms.

Treatments known to be effective in preventing hair loss or promoting hair growth include application of minoxidil solution or administration of trichosaccharide. Minoxidil was developed as a vasodilator for the treatment of hypertension, but as a side effect of hirsutism was reported, it was developed as a hair growth agent. Although the mechanism of action for the hair growth effect of minoxidil has not yet been clearly elucidated, it is thought that hair growth is induced by an increase in nutrient supply through vasodilation. In addition, finasteride is a substance that inhibits the activity of 5 alpha-reductase, an enzyme acting on male hormone metabolism, and was initially developed as a treatment for benign prostatic hyperplasia.

However, minoxidil and finasteride are inconvenient to use continuously because their effects disappear when they are stopped. In the case of minoxidil, there are side effects such as sticky feeling and skin irritation. As a result, continuous use is limited.

Korean Patent Registration No. 10-1043825 (June 16, 2011) describes a pharmaceutical composition for preventing or treating diseases caused by angiogenesis containing xanthohumol or its derivatives as an active ingredient. Korean Patent Registration No. 10-1323150 (October 23, 2013) describes a composition for preventing and treating osteoporosis containing xanthohumol.

An object of the present invention is to provide a composition having an effect of preventing hair loss or promoting hair growth.

The present invention disodium laureth sulfosuccinate, butylene glycol, lauryl glucoside, 1,2-hexanediol, brewer's yeast extract, cocamide mipa, polyquaternium-10, glycerin, lauryl hydrox It provides a cosmetic composition comprising sulfite, menthol, salicylic acid, panthenol, tromethamine, sodium chloride, ethylhexylglycerin, disodium EDIT, niacinamide, xanthohumol, and purified water.

In the present invention, the cosmetic composition preferably contains 5 to 15% by weight of disodium laurethsulfosuccinate, 1 to 5% by weight of butylene glycol, 1 to 5% by weight of lauryl glucoside, based on the total weight of the cosmetic composition. wt%, 1,2-hexanediol 1-5 wt%, brewer’s yeast extract 0.1-3 wt%, cocamide mipa 0.1-3 wt%, polyquaternium-10 0.1-3 wt%, glycerin 0.1-3 wt% Weight %, lauryl hydroxysultaine 0.01 to 1 weight %, menthol 0.01 to 1 weight %, salicylic acid 0.01 to 1 weight %, panthenol 0.01 to 1 weight %, tromethamine 0.01 to 1 weight %, sodium chloride 0.001 ~0.5% by weight, ethylhexylglycerin 0.001 to 0.5% by weight, disodium EDTA 0.001 to 0.5% by weight, niacinamide 0.001 to 0.5% by weight, xanthohumol 0.0001 to 0.1% by weight, and the remainder of purified water.

In the present invention, the cosmetic composition preferably further comprises caramel, citronellol, limonene, and linalool.

In the present invention, the cosmetic composition, more preferably, 5 to 15% by weight of disodium laurethsulfosuccinate, 1 to 5% by weight of butylene glycol, 1 to lauryl glucoside, based on the total weight of the cosmetic composition 5% by weight, 1,2-hexanediol 1 to 5% by weight, brewer's yeast extract 0.1 to 3% by weight, cocamide mipa 0.1 to 3% by weight, polyquaternium-10 0.1 to 3% by weight, glycerin 0.1 to 3 wt%, lauryl hydroxysultaine 0.01 to 1 wt%, menthol 0.01 to 1 wt%, salicylic acid 0.01 to 1 wt%, panthenol 0.01 to 1 wt%, tromethamine 0.01 to 1 wt%, sodium chloride 0.001 to 0.5% by weight, ethylhexylglycerin 0.001 to 0.5% by weight, disodium EDTA 0.001 to 0.5% by weight, niacinamide 0.001 to 0.5% by weight, xanthohumol 0.0001 to 0.1% by weight, caramel 0.0001 to 0.1% by weight, sheet It is preferable to be composed of 0.0001 to 0.1% by weight of ronelol, 0.0001 to 0.1% by weight of limonene, 0.0001 to 0.1% by weight of linalool, and the remaining amount of purified water.

The present invention provides a composition excellent in preventing hair loss or promoting hair growth by including xanthohumol. The cosmetic composition of the present invention can provide a cosmetic composition excellent in preventing hair loss or promoting hair growth, including xanthohumol contained in 101 bottles of beer (500 ml) based on 500 g of the cosmetic composition.

In addition, the present invention has the advantage of excellent feeling after use of the cosmetic composition.

The present invention provides a cosmetic composition for preventing hair loss or promoting hair growth comprising xanthohumol. Xanthohumol is a chalcone contained in hops, which helps to excrete harmful components from the body, and is known to have effects such as reducing oxidative stress, cancer, regulating fat metabolism, reducing cholesterol, preventing osteoporosis, and preventing heart disease. Xanthohumol is generally extracted from the female inflorescence of hops.

Hops are vines of the Morus family and have a characteristic aroma and bitter taste, and are used to make beer. It has been found that hops have a hypnotic effect with no side effects based on the fact that they fall asleep while harvesting hops. As the cosmetic composition of the present invention contains xanthohumol, it is possible to supply abundant nutrition to the hair, and to exhibit antioxidant and hair conditioning effects.

The present invention disodium laureth sulfosuccinate, butylene glycol, lauryl glucoside, 1,2-hexanediol, brewer's yeast extract, cocamide mipa, polyquaternium-10, glycerin, lauryl hydrox It provides a cosmetic composition comprising sulfite, menthol, salicylic acid, panthenol, tromethamine, sodium chloride, ethylhexylglycerin, disodium EDIT, niacinamide, xanthohumol, and purified water.

In the present invention, the cosmetic composition preferably contains 5 to 15% by weight of disodium laurethsulfosuccinate, 1 to 5% by weight of butylene glycol, 1 to 5% by weight of lauryl glucoside, based on the total weight of the cosmetic composition. wt%, 1,2-hexanediol 1-5 wt%, brewer’s yeast extract 0.1-3 wt%, cocamide mipa 0.1-3 wt%, polyquaternium-10 0.1-3 wt%, glycerin 0.1-3 wt% Weight %, lauryl hydroxysultaine 0.01 to 1 weight %, menthol 0.01 to 1 weight %, salicylic acid 0.01 to 1 weight %, panthenol 0.01 to 1 weight %, tromethamine 0.01 to 1 weight %, sodium chloride 0.001 ~0.5% by weight, ethylhexylglycerin 0.001 to 0.5% by weight, disodium EDTA 0.001 to 0.5% by weight, niacinamide 0.001 to 0.5% by weight, xanthohumol 0.0001 to 0.1% by weight, and the remainder of purified water.

In the present invention, butylene glycol, 1,2-hexanediol, glycerin, and ethylhexyl glycerin were used as solvents, and by using them, the moisturizing effect and the antiseptic effect could be increased.

Disodium Laureth Sulfosuccinate, Lauryl Glucoside, Cocamide MIPA, and Lauryl Hydroxysultaine are surfactants.

Saccharomyces Cerevisiae Extract is separated and dried during the beer manufacturing process, and contains various nutrients such as minerals and vitamins. Brewer's yeast extract is known to be effective in pore consolidation, weight control, intestinal health, anti-aging, etc., and the present invention enables shiny and healthy hair care by using a specific amount of brewer's yeast extract.

Polyquaternium-10 is an antistatic agent, and in the cosmetic composition of the present invention, it has effects such as preventing disorder of hair after washing hair and preventing static electricity when combing.

As the cosmetic composition of the present invention contains menthol, it is possible to feel refreshed on the scalp after washing the hair, and to impart a cooling effect. However, as the amount of menthol added was limited to a certain amount, there was no skin irritation.

Salicylic Acid is an ingredient extracted from the bark of willows and birch trees. The present invention has the effect of removing dead skin cells and dandruff from the scalp by adding a specific amount of salicylic acid.

Panthenol is a provitamin B5 component, which is converted to vitamin B5 in the skin to exert a moisturizing effect. As a non-irritating ingredient, it has moisturizing effects as well as strengthening the skin barrier and regenerating the skin. According to the present invention, when a specific amount of panthenol is added, there is a hair strengthening effect according to the cuticle strengthening effect. On the other hand, when panthenol is used in excess, oily and sticky feeling may decrease, but according to the present invention, a cosmetic composition with excellent feel was prepared by using a specific amount of panthenol.

Niacinamide is known to have a whitening effect by suppressing melanin pigment, and when used in excess, there is a risk of skin irritation. The present invention significantly reduced the concern of skin irritation according to the use of a specific amount of niacinamide.

Tromethamine is a pH adjuster. When the scalp pH increases, eczema, dermatitis, hair loss, etc. are induced. Accordingly, it is good to adjust the pH of the cosmetic composition for preventing hair loss to a slightly acidic level of 4.5 to 6.5.

Sodium Chloride (Sodium Chloride) is a viscosity modifier, Disodium EDTA (Disodium EDTA) is a sequestering agent.

In the present invention, the cosmetic composition preferably further comprises caramel, citronellol, limonene, and linalool. Caramel is preferably added to adjust the color of the cosmetic composition, and Citronellol, Limonene, and Linalool are added to impart flavor to the cosmetic composition of the present invention. good night.

In the present invention, the cosmetic composition, more preferably, 5 to 15% by weight of disodium laurethsulfosuccinate, 1 to 5% by weight of butylene glycol, 1 to lauryl glucoside, based on the total weight of the cosmetic composition 5% by weight, 1,2-hexanediol 1 to 5% by weight, brewer's yeast extract 0.1 to 3% by weight, cocamide mipa 0.1 to 3% by weight, polyquaternium-10 0.1 to 3% by weight, glycerin 0.1 to 3 wt%, lauryl hydroxysultaine 0.01 to 1 wt%, menthol 0.01 to 1 wt%, salicylic acid 0.01 to 1 wt%, panthenol 0.01 to 1 wt%, tromethamine 0.01 to 1 wt%, sodium chloride 0.001 to 0.5% by weight, ethylhexylglycerin 0.001 to 0.5% by weight, disodium EDTA 0.001 to 0.5% by weight, niacinamide 0.001 to 0.5% by weight, xanthohumol 0.0001 to 0.1% by weight, caramel 0.0001 to 0.1% by weight, sheet It is preferable to be composed of 0.0001 to 0.1% by weight of ronelol, 0.0001 to 0.1% by weight of limonene, 0.0001 to 0.1% by weight of linalool, and the remaining amount of purified water.

Hereinafter, the present invention will be described in more detail in the following Examples and Experimental Examples. In many cases, the scope of the present invention is not limited only to the following examples and experimental examples, and includes all modifications of the technical idea equivalent thereto.

[Example 1: Preparation of shampoo composition containing xanthohumol]

In this practice, a shampoo composition containing xanthohumol was prepared. Based on the total composition, disodium laureth sulfosuccinate 11.40% by weight, butylene glycol 3.45% by weight, lauryl glucoside 2.5% by weight, 1,2-hexanediol 2.03% by weight, brewer's yeast extract 1.02% by weight, Cocamide mipa 1% by weight, Polyquaternium-10 1% by weight, glycerin 1% by weight, laurylhydroxysultaine 0.56% by weight, menthol 0.30% by weight, salicylic acid 0.25% by weight, panthenol 0.20% by weight, Tro Methamine 0.10% by weight, sodium chloride 0.06% by weight, ethylhexylglycerin 0.05% by weight, disodium EDTA 0.05% by weight, niacinamide 0.01% by weight, xanthohumol 0.008% by weight, caramel 0.0125% by weight, citronellol 0.0137% by weight %, limonene 0.0142% by weight, linalool 0.0415% by weight, and the remaining amount of purified water (added to make a total of 100%) were mixed to prepare a shampoo composition containing xanthohumol.

[Experimental Example 1: Confirmation of hair loss prevention or hair growth promoting effect of cosmetic composition containing xanthohumol]

In this experiment, the effect of preventing hair loss or promoting hair growth according to the use of the cosmetic composition containing xanthohumol prepared according to Example 1 was confirmed.

Thirty adults in their 20s and 50s were randomly selected to use the cosmetic composition once a day for 4 weeks. For the cosmetic composition, take an appropriate amount while the hair is wet, massage lightly, and then rinse thoroughly with lukewarm water. 15 people used the cosmetic composition of the present invention (Example 1), and 15 people used the cosmetic composition (control group) containing the same amount of purified water instead of xanthohumol as a control group. The effect of preventing hair loss or promoting hair growth according to the use of each cosmetic composition was visually observed and the average value was shown in Table 1 below using a 5-point scale method (1: very bad, 5: very good).

Example 1 control 1 week 3.6 2.8 2 weeks 3.8 2.6 3 weeks 4.2 2.4 4 weeks 4.8 2.4

As shown in Table 1, the effect of preventing hair loss or promoting hair growth was confirmed according to the use of the cosmetic composition of the present invention.

[Comparative Example 1-3: Preparation of shampoo composition containing xanthohumol]

A shampoo composition containing xanthohumol was prepared in the same manner as in Example 1.

Example 1
(100%) Comparative Example 1
(100%) Comparative Example 2
(100%) Comparative Example 3
(100%) Purified water remaining amount
(to 100) remaining amount
(to 100) remaining amount
(to 100) remaining amount
(to 100) Disodium Laureth Sulfosuccinate 11.40 11.40 11.40 11.40 Butylene Glycol 3.45 3.45 3.45 3.45 Lauryl Glucoside 2.5 2.5 2.5 2.5 1,2-Hexanediol 2.03 2.03 2.03 2.03 brewer's yeast extract 1.02 1.02 0 0 cocamide mipa One One One One Polyquaternium-10 One One One One glycerin One One One One lauryl hydroxysultaine 0.56 0.56 0.56 0.56 menthol 0.3 0.2 0.1 0 Salicylic Acid 0.25 0.25 0.25 0.25 panthenol 0.20 0 1.5 0 tromethamine 0.10 0.10 0.10 0.10 sodium chloride 0.06 0.06 0.06 0.06 Ethylhexylglycerin 0.05 0.05 0.05 0.05 Disodium EDIT 0.05 0.05 0.05 0.05 Niacinamide 0.01 0.01 0.01 0.01 xantho humol 0.008 0.2 0.1 0.006 Caramel 0.0125 0.0125 0 0.0125 Citronellol 0.0137 0 0.0137 0.0137 limonene 0.0142 0 0.0142 0.0142 linalul 0.0415 0 0.0415 0.0415

[Experimental Example 2: Evaluation of feeling of use of a cosmetic composition containing xanthohumol]

In this experiment, the fragrance, foaming power, cleaning power, hair gloss, and moisturizing feeling according to the use of the cosmetic composition were confirmed for the person who used the cosmetic composition (Example 1) of the present invention in Experimental Example 1 above. The average values are shown in Table 3 below by using a five-point scale method (1: very bad, 5: very good) for fragrance, foaming power, cleaning power, hair gloss, and moisturizing feeling according to the use of the cosmetic composition.

incense bubble
generative detergency hair shine moisturizing Example 1 4.8 4.6 4.8 4.6 4.8

According to Table 3, it was confirmed that the feeling of use of the cosmetic composition of the present invention was excellent. In particular, as the cosmetic composition according to the present invention contains citronellol, limonene, and linalool, it was found that the feeling of use was high by adding the fragrance of the cosmetic composition. In addition, as the cosmetic composition of the present invention contains menthol, it is possible to clean the scalp, and as it contains xanthohumol and brewer's yeast extract, it is possible to keep hair shiny and healthy. In addition, by including panthenol, moisture evaporation was prevented and moisture was maintained.

[Experimental Example 3: Evaluation of feeling of use of a cosmetic composition containing xanthohumol]

In this experiment, the appearance of the cosmetic composition of Example 1 and the cosmetic compositions of Comparative Examples 1 to 3 and the feeling of use after using these cosmetic compositions for fragrance, moisture, hair shine, and freshness after washing were performed using a 5-point scale method (1: very bad, 5 : Very good) and the average values are shown in Table 4 below.

color incense moisturizing hair shine freshness Example 1 4.8 4.8 4.8 4.6 4.8 Comparative Example 1 4.2 2.4 2.4 3.4 2.8 Comparative Example 2 2.6 4.0 3.6 2.6 2.8 Comparative Example 3 4.4 4.2 2.2 2.2 2.2

The appearance of the cosmetic composition had different preferences depending on whether or not the caramel color was added. Since the present invention is a cosmetic composition containing beer-derived xanthohumol, it was found that a cosmetic composition closer to beer color received high evaluation.

On the other hand, as the cosmetic composition of the present invention contains citronellol, limonene, and linalool, the fragrance remains on the hair, and thus the feeling of use is good.

In addition, in the present invention, it was confirmed that the moisturizing effect appeared as the panthenol was included, and in the case of Comparative Example 2, the moisturizing feeling was observed, but the sticky feeling was accompanied by the addition of the panthenol in excess.

In addition, in the present invention, Example 1 using both brewer's yeast extract and xanthohumol was able to manage hair with good shine and healthy hair, but Comparative Example 1, in which xanthohumol was added in a relatively excessive amount, had an unstable formulation, so the hair shine effect was insignificant. appeared to be In Comparative Examples 2 and 3, which did not use brewer's yeast extract and only xanthohumol was used, hair gloss was insignificant and nutrition was insufficient, so the feeling of use was poor.

On the other hand, as the amount of menthol added decreased, the degree of refreshing feeling after washing was lower, and in Comparative Example 1, dryness was accompanied and the feeling of use was low. In Comparative Example 2, the moisturizing effect was exhibited by using the panthenol together and the feeling was relatively good. In addition, Comparative Example 3 in which neither menthol nor panthenol was used showed a very low feeling of use.

Claims (4)

Disodium laureth sulfosuccinate, butylene glycol, lauryl glucoside, 1,2-hexanediol, brewer's yeast extract, cocamide mipa, polyquaternium-10, glycerin, lauryl hydroxysultaine, A cosmetic composition comprising menthol, salicylic acid, panthenol, tromethamine, sodium chloride, ethylhexylglycerin, disodium EDTA, niacinamide, xanthohumol, and purified water.
According to claim 1,
The cosmetic composition,
Based on the total weight of the cosmetic composition, disodium laureth sulfosuccinate 5 to 15% by weight, butylene glycol 1 to 5% by weight, lauryl glucoside 1 to 5% by weight, 1,2-hexanediol 1 to 5 Weight %, brewer's yeast extract 0.1-3 weight %, cocamide mipa 0.1-3 weight %, polyquaternium-10 0.1-3 weight %, glycerin 0.1-3 weight %, lauryl hydroxysultaine 0.01-1 weight %, menthol 0.01 to 1 wt%, salicylic acid 0.01 to 1 wt%, panthenol 0.01 to 1 wt%, tromethamine 0.01 to 1 wt%, sodium chloride 0.001 to 0.5 wt%, ethylhexylglycerin 0.001 to 0.5 wt% , Disodium EDI 0.001 to 0.5% by weight, niacinamide 0.001 to 0.5% by weight, xanthohumol 0.0001 to 0.1% by weight, cosmetic composition, characterized in that it is composed of purified water of the remainder.
According to claim 1,
The cosmetic composition,
A cosmetic composition comprising caramel, citronellol, limonene, and linalool.
4. The method of claim 3,
The cosmetic composition,
Based on the total weight of the cosmetic composition, disodium laureth sulfosuccinate 5 to 15% by weight, butylene glycol 1 to 5% by weight, lauryl glucoside 1 to 5% by weight, 1,2-hexanediol 1 to 5 Weight %, brewer's yeast extract 0.1-3 weight %, cocamide mipa 0.1-3 weight %, polyquaternium-10 0.1-3 weight %, glycerin 0.1-3 weight %, lauryl hydroxysultaine 0.01-1 weight %, menthol 0.01 to 1 wt%, salicylic acid 0.01 to 1 wt%, panthenol 0.01 to 1 wt%, tromethamine 0.01 to 1 wt%, sodium chloride 0.001 to 0.5 wt%, ethylhexylglycerin 0.001 to 0.5 wt% , disodium EDTA 0.001 to 0.5 wt%, niacinamide 0.001 to 0.5 wt%, xanthohumol 0.0001 to 0.1 wt%, caramel 0.0001 to 0.1 wt%, citronellol 0.0001 to 0.1 wt%, limonene 0.0001 to 0.1 wt% , 0.0001 to 0.1% by weight of linalool, a cosmetic composition comprising the remaining amount of purified water.