KR20220133198A - 디하이드로오로테이트 탈수소효소를 항-cd38 치료제와 조합하여 억제하는 방법 및 조성물 - Google Patents

디하이드로오로테이트 탈수소효소를 항-cd38 치료제와 조합하여 억제하는 방법 및 조성물 Download PDF

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KR20220133198A
KR20220133198A KR1020227025804A KR20227025804A KR20220133198A KR 20220133198 A KR20220133198 A KR 20220133198A KR 1020227025804 A KR1020227025804 A KR 1020227025804A KR 20227025804 A KR20227025804 A KR 20227025804A KR 20220133198 A KR20220133198 A KR 20220133198A
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compound
halogen
hydrogen
alkyl
pharmaceutical composition
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죤 씨 비르드
에린 허틀라인
올라 에이 엘가몰
마리아 엘 죤슨
서스힐라 트리단다파니
차드 이 버네트
샌딥 마드후커 비브허트
토마스 이 굳윈
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오하이오 스테이트 이노베이션 파운데이션
헨드릭스 칼리지
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KR1020227025804A 2019-12-26 2020-12-26 디하이드로오로테이트 탈수소효소를 항-cd38 치료제와 조합하여 억제하는 방법 및 조성물 Pending KR20220133198A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962953860P 2019-12-26 2019-12-26
US62/953,860 2019-12-26
PCT/US2020/067074 WO2021134045A1 (en) 2019-12-26 2020-12-26 Methods and compositions for inhibition of dihydroorotate dehydrogenase in combination with an anti-cd38 therapeutic agent

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KR20220133198A true KR20220133198A (ko) 2022-10-04

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KR1020227025804A Pending KR20220133198A (ko) 2019-12-26 2020-12-26 디하이드로오로테이트 탈수소효소를 항-cd38 치료제와 조합하여 억제하는 방법 및 조성물

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US (1) US20230303710A1 (https=)
EP (1) EP4081219A4 (https=)
JP (2) JP7736275B2 (https=)
KR (1) KR20220133198A (https=)
CN (1) CN115335052A (https=)
AU (1) AU2020412805A1 (https=)
CA (1) CA3165475A1 (https=)
WO (1) WO2021134045A1 (https=)

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Publication number Priority date Publication date Assignee Title
AU2020411507A1 (en) * 2019-12-26 2022-07-14 Hendrix College Methods and compositions for inhibition of dihydroorotate dehydrogenase
WO2023278778A1 (en) * 2021-06-30 2023-01-05 Ohio State Innovation Foundation Methods and compositions for inhibition of dihydroorotate dehydrogenase in combination with an anti-cd47-sirpα therapeutic agent
US20250009740A1 (en) * 2021-11-22 2025-01-09 Ohio State Innovation Foundation Methods and compositions for targeting alternative metabolism along with flt3 inhibitor-mediated antileukemic actions
WO2025202415A1 (en) * 2024-03-28 2025-10-02 Institut National de la Santé et de la Recherche Médicale Dhodh inhibitors for use in the chronopharmacoligical treatment and prevention of obesity and obesity-related metabolic disorders

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US7405237B2 (en) * 2004-07-28 2008-07-29 Celgene Corporation Isoindoline compounds and methods of their use
EP2567976B1 (en) * 2005-03-23 2017-07-19 Genmab A/S Antibodies against CD38 for treatment of multiple myeloma
JP6055404B2 (ja) * 2010-06-15 2016-12-27 ゲンマブ エー／エス 組織因子に対するヒト抗体薬物結合体
WO2017037022A1 (en) * 2015-09-01 2017-03-09 Bayer Pharma Aktiengesellschaft Compounds and methods useful for treating or preventing hematological cancers
EP3397625A4 (en) * 2015-12-30 2019-12-25 Agios Pharmaceuticals, Inc. TREATMENT OF TUMORS WITH MUTANT ISOCITRATE DEHYDROGENASE
US10478497B2 (en) * 2016-07-20 2019-11-19 Hybrigenics S.A. Combinations of inecalcitol with an anti-CD38 agent and their uses for treating cancer
EP3661557B1 (en) * 2017-07-31 2025-09-03 Actinium Pharmaceuticals, Inc. Treatments for a hematological malignancy
WO2019246603A1 (en) * 2018-06-22 2019-12-26 Ohio State Innovation Foundation Methods and compositions for inhibition of dihydroorotate dehydrogenase
AU2020411507A1 (en) * 2019-12-26 2022-07-14 Hendrix College Methods and compositions for inhibition of dihydroorotate dehydrogenase
EP4081520A1 (en) * 2019-12-26 2022-11-02 Ohio State Innovation Foundation Compositions for use in the inhibition of dihydroorotate dehydrogenase
US20230109418A1 (en) * 2019-12-26 2023-04-06 Ohio State Innovation Foundation Compositions for use for the inhibition of dihydroorotate dehydrogenase

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CN115335052A (zh) 2022-11-11
AU2020412805A1 (en) 2022-07-14
EP4081219A1 (en) 2022-11-02
JP7736275B2 (ja) 2025-09-09
US20230303710A1 (en) 2023-09-28
JP2025186252A (ja) 2025-12-23
CA3165475A1 (en) 2021-07-01
EP4081219A4 (en) 2024-01-17
WO2021134045A1 (en) 2021-07-01
JP2023508938A (ja) 2023-03-06

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