KR20220131292A

KR20220131292A - Gip/glp1 공동-효능제 화합물

Info

Publication number: KR20220131292A
Application number: KR1020227028667A
Authority: KR
Inventors: 조르그 앨시나-페르난데즈; 로버트 앤드류 브라운; 로버트 채드윅 커민스; 모하메드 엘사예드 하메드 엘사예드; 안드레아 레니 게이저; 시아니인 라이; 홍창 추; 브라이언 모건 왓슨
Original assignee: 일라이 릴리 앤드 캄파니
Priority date: 2020-01-23
Filing date: 2021-01-21
Publication date: 2022-09-27
Also published as: AU2021211451B2; AU2021211451A1; TWI770781B; JP2023511441A; US20230265151A1; AR121093A1; IL294955A; MX2022009149A; EP4093757A1; BR112022014397A2; CN115298207A; WO2021150673A1; CA3165430A1; TW202140528A

Abstract

본 발명은 인간 글루코스-의존성 인슐린분비자극 폴리펩티드 (GIP) 및 글루카곤-유사 펩티드-1 (GLP-1) 수용체 둘 다에서 활성을 갖는 화합물에 관한 것이다. 본 발명은 또한 이들 수용체 각각에서 연장된 작용 지속기간을 갖는 화합물에 관한 것이다. 또한, 본 발명은 경구로 투여될 수 있는 화합물에 관한 것이다. 이들 화합물은 제2형 당뇨병 ("T2DM")의 치료에 유용할 수 있다. 이들 화합물은 비만의 치료에 유용할 수 있다.

Description

GIP/GLP1 공동-효능제 화합물

본 발명은 인간 글루코스-의존성 인슐린분비자극 폴리펩티드 (GIP) 및 글루카곤-유사 펩티드-1 (GLP-1) 수용체 둘 다에서 활성을 갖는 화합물에 관한 것이다. 본 발명은 또한 이들 수용체 각각에서 연장된 작용 지속기간을 갖는 화합물에 관한 것이다. 또한, 본 발명은 경구로 투여될 수 있는 화합물에 관한 것이다. 이들 화합물은 제2형 당뇨병 ("T2DM")의 치료에 유용할 수 있다. 또한, 화합물은 비만의 치료에 유용할 수 있다.

지난 수십년에 걸쳐, 당뇨병의 유병률은 계속 상승하였다. T2DM은 모든 당뇨병의 대략 90%를 차지하는 가장 흔한 형태의 당뇨병이다. T2DM은 주로 인슐린 저항성과 연관된 높은 혈액 글루코스 수준을 특징으로 한다. T2DM에 대한 현행 표준 관리는 식이 및 운동, 경구 의약으로의 치료, 및 인크레틴-기반 요법, 예컨대 GLP-1 수용체 효능제를 포함한 주사가능한 글루코스 강하 약물을 포함한다. 다양한 GLP-1 수용체 효능제가 T2DM의 치료를 위해 현재 이용가능하지만, 현재 시판되는 GLP-1 수용체 효능제는 일반적으로 위장 부작용, 예컨대 오심 및 구토로 인해 용량-제한된다. 피하 주사는 이용가능한 GLP-1 수용체 효능제를 위한 전형적인 투여 경로이다. 경구 의약 및 인크레틴-기반 요법으로의 치료가 불충분한 경우에, 인슐린 치료가 고려된다. 오늘날 이용가능한 치료의 진전에도 불구하고, 많은 T2DM 환자는 그의 혈당 조절 목표에 도달할 수 없다. 비제어된 당뇨병은 환자의 증가된 이환율 및 사망률과 연관된 여러 상태로 이어진다. 더 많은 T2DM 환자가 그의 혈당 치료 목표에 도달할 수 있게 하는 치료에 대한 필요가 존재한다.

비만은 지방 조직 덩어리의 과도한 축적을 초래하는 복합적 의학적 장애이다. 오늘날의 비만은 바람직하지 않은 건강 결과 및 이환율과 연관된 세계적 공중 보건 문제이다. 비만 환자를 위한 목적하는 치료는 과도한 체중을 감소시키고, 비만-관련 동반이환율을 개선시키고, 장기간 체중 감소를 유지시키고자 노력한다. 비만에 대한 이용가능한 치료는 중증 비만을 갖는 환자에게 특히 불만족스럽다. 치료적 체중 감소를 유도하기 위해 이러한 치료를 필요로 하는 환자에서 대체 치료 옵션에 대한 필요가 존재한다.

WO2016/111971은 GLP-1 및 GIP 활성을 갖는 것으로 언급된 펩티드를 기재한다. WO2013/164483도 또한 GLP-1 및 GIP 활성을 갖는 것으로 언급된 화합물을 개시한다.

T2DM 치료를 필요로 하는 환자의 보다 많은 부분에 대해 효과적인 글루코스 조절을 제공할 수 있는 T2DM 치료에 대한 필요가 존재한다. 효과적인 글루코스 조절 및 유리한 부작용 프로파일을 제공할 수 있는 T2D 치료에 대한 추가의 필요가 존재한다. 치료적 체중 감소를 제공하기 위해 이러한 치료를 필요로 하는 환자에서 대체 치료 옵션에 대한 필요가 존재한다. 중증 비만에 대한 치료를 필요로 하는 환자에 대해 대체 치료 옵션에 대한 필요가 존재한다.

경구 투여에 적합한, GIP 및 GLP-1 수용체에서 효능제 활성을 갖는 화합물에 대한 요구가 존재한다. GIP 및 GLP-1 수용체 각각에서 연장된 작용 지속기간을 갖는 화합물은 화합물의 덜 빈번한 투여를 가능하게 하는데 바람직하다. 단일 화합물로부터 GLP-1 및 GIP 활성을 제공하기 위해 아미노산 서열과 조합된 2개의 아실화 변형을 갖는 화합물이 바람직하다.

따라서, 하기 화학식 I의 화합물 또는 그의 제약상 허용되는 염이 제공되며:

X₁X₂EGTX₆TSDX₁₀X₁₁X₁₂X₁₃LDX₁₆X₁₇AQX₂₀X₂₁X₂₂IX₂₄X₂₅LIX₂₈GX₃₀

(서열식별번호(SEQ ID NO): 505)

여기서

X₁은 Y 및 R₁Y로 이루어진 군으로부터 선택되고;

R₁은 N-말단 아미노 기의 Ac 변형이고;

X₂는 Aib이고;

X₆은 αMeF 및 αMeF(2F)로 이루어진 군으로부터 선택되고;

X₁₀은 4Pal, Y, αMeF, αMeF(2F), αMeL, αMeV, Ac4c, Ac5c, Ac6c, Bip, 1Nal, 2Nal, OMeY, hTyr, Nle, V, 4CPhe, ChG, ChA, Bzt, 2FA, 4TAA, 2TA, 3TA, 및 KZ₁로 이루어진 군으로부터 선택되고;

X₁₁은 S, αMeS, Aib, G, Dap, Ac5c, 및 Tle로 이루어진 군으로부터 선택되고;

X₁₂는 I 및 KZ₁로 이루어진 군으로부터 선택되고;

X₁₃은 αMeL 및 αMeF로 이루어진 군으로부터 선택되고;

X₁₆은 Orn이고;

X₁₇은 Q, I, 및 KZ₁로 이루어진 군으로부터 선택되고;

X₂₀은 Aib, Orn, 4Pal, αMeF, Ac5c, 및 Ac6c로 이루어진 군으로부터 선택되고;

X₂₁은 E, KZ₁, G, Orn, 및 4Pal로 이루어진 군으로부터 선택되고;

X₂₂는 F, 2ClPhe, 3ClPhe, 2FPhe, 3FPhe, 3,5FPhe, 1Nal, 2Nal, αMeF(2F), ChA, Bzt, 및 αMeF로 이루어진 군으로부터 선택되고;

X₂₄는 D-Glu, E, G, 및 KZ₁로 이루어진 군으로부터 선택되고;

X₂₅는 Y, αMeY, αMeF, 및 KZ₁로 이루어진 군으로부터 선택되고;

X₂₈은 E, Orn, 및 KZ₁로 이루어진 군으로부터 선택되고;

X₃₀은 G, Orn, KZ₁, K(Z₁)R₆, OrnR₂, 및 GR₂로 이루어진 군으로부터 선택되고;

R₂는 X₃₁, X₃₁SSG(서열식별번호: 5), X₃₁SSG-R₃ (서열식별번호: 6), X₃₁SSGX₃₅PPPX₃₉ (서열식별번호: 7), X₃₁SSGX₃₅PPPX₃₉R₃ (서열식별번호: 8), X₃₁SSGX₃₅PPPX₃₉X₄₀ (서열식별번호: 9), X₃₁SSGX₃₅PPPX₃₉X₄₀R₃ (서열식별번호: 10), 및 변형이 NH₂인 c-말단 기의 변형으로 이루어진 군으로부터 선택되고;

R₆은 PSSG(서열식별번호: 506), PSSG-R₃ (서열식별번호: 507), PSSGX₃₅PPPX₃₉ (서열식별번호: 508), PSSGX₃₅PPPX₃₉R₃ (서열식별번호: 509), PSSGX₃₅PPPX₃₉X₄₀ (서열식별번호: 510), PSSGX₃₅PPPX₃₉X₄₀R₃ (서열식별번호: 511), 및 변형이 NH₂인 c-말단 기의 변형으로 이루어진 군으로부터 선택되고;

X₃₁은 P 및 KZ₁로 이루어진 군으로부터 선택되고;

X₃₅는 A 및 Orn으로 이루어진 군으로부터 선택되고;

X₃₉는 S 및 Orn으로 이루어진 군으로부터 선택되고;

X₄₀은 KZ₁이고;

R₃은 변형이 NH₂인 C-말단 기의 변형이고;

여기서 X₁₀, X₁₂, X₁₇, X₂₁, X₂₄, X₂₅, X₂₈, X₃₀, X₃₁, 및 X₄₀ 중 2개, 및 오직 2개는 KZ₁ 또는 K(Z₁)R₆이고;

Z₁은 R₅ 및 -R₄R₅로 이루어진 군으로부터 선택되고;

R₄는 링커이고;

R₅는 지방산이다.

하기 화학식 II의 화합물 또는 그의 제약상 허용되는 염이 제공되며:

X₁X₂EGTX₆TSDX₁₀X₁₁X₁₂X₁₃LDX₁₆X₁₇AQX₂₀X₂₁X₂₂IX₂₄X₂₅LIX₂₈GX₃₀ (서열식별번호: 4)

여기서

X₁은 Y 및 R₁Y로 이루어진 군으로부터 선택되고;

R₁은 N-말단 아미노 기의 Ac 변형이고;

X₂는 Aib이고;

X₆은 αMeF 및 αMeF(2F)로 이루어진 군으로부터 선택되고;

X₁₁은 Ac5c, S, αMeS, Aib, G, Dap, 및 Tle로 이루어진 군으로부터 선택되고;

X₁₂는 I 및 KZ₁로 이루어진 군으로부터 선택되고;

X₁₃은 αMeL 및 αMeF로 이루어진 군으로부터 선택되고;

X₁₆은 Orn이고;

X₁₇은 Q, I, 및 KZ₁로 이루어진 군으로부터 선택되고;

X₂₄는 D-Glu, E, G, 및 KZ₁로 이루어진 군으로부터 선택되고;

X₂₈은 E, Orn, 및 KZ₁로 이루어진 군으로부터 선택되고;

X₃₀은 G, Orn, KZ₁, 및 GR₂로 이루어진 군으로부터 선택되고;

R₂는 X₃₁SSG(서열식별번호: 5), X₃₁SSG-R₃ (서열식별번호: 6), X₃₁SSGX₃₅PPPX₃₉ (서열식별번호: 7), X₃₁SSGX₃₅PPPX₃₉R₃ (서열식별번호: 8), X₃₁SSGX₃₅PPPX₃₉X₄₀ (서열식별번호: 9), X₃₁SSGX₃₅PPPX₃₉X₄₀R₃ (서열식별번호: 10), 및 변형이 NH₂인 c-말단 기의 변형으로 이루어진 군으로부터 선택되고;

X₃₁은 P 및 KZ₁로 이루어진 군으로부터 선택되고;

X₃₅는 A 및 Orn으로 이루어진 군으로부터 선택되고;

X₃₉는 S 및 Orn으로 이루어진 군으로부터 선택되고;

X₄₀은 KZ₁이고;

R₃은 변형이 NH₂인 C-말단 기의 변형이고;

여기서 X₁₀, X₁₂, X₁₇, X₂₁, X₂₄, X₂₅, X₂₈, X₃₀, X₃₁, 및 X₄₀ 중 2개, 및 오직 2개는 KZ₁이고;

Z₁은 R₅ 및 -R₄R₅로 이루어진 군으로부터 선택되고;

R₄는 링커이고;

R₅는 지방산이다.

Z₁이 하기로 이루어진 군으로부터 선택된 것인 화학식 I의 펩티드 또는 그의 제약상 허용되는 염이 제공된다:

-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-CO-(CH₂)₁₂-CO₂H,

-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-CO-(CH₂)₁₀-CO₂H,

-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-(10-(4-카르복시페녹시)데카노일),

-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-(4-(4-아이오도페닐)부타노일),

-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-(4-(4-tert-부틸페닐)부타노일),

-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-CO-(CH₂)₁₄-CH₃,

-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-CO-(CH₂)₁₂-CH₃,

-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-CO-(CH₂)₁₀-CH₃,

-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-CO-(CH₂)₁₂-CO₂H,

-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(10-(4-카르복시페녹시)데카노일),

-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(γ-Glu)-CO-(CH₂)₁₂-CO₂H,

-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(γ-Glu)-(10-(4-카르복시페녹시)데카노일),

-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(γ-Glu)-CO-(CH₂)₁₄-CH₃,

-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(γ-Glu)-CO-(CH₂)₁₀-CH₃,

-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₃-(γ-Glu)-CO-(CH₂)₁₂-CO₂H,

-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₃-(γ-Glu)-CO-(CH₂)₁₄-CH₃,

-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(εK)-CO-(CH₂)₁₂-CO₂H,

-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(εK)-(γ-Glu)-CO-(CH₂)₁₂-CO₂H,

-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(εK)-(γ-Glu)-CO-(CH₂)₁₂-CO₂H,

-(εK)-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(γ-Glu)-CO-(CH₂)₁₂-CO₂H,

-(εK)-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-CO-(CH₂)₁₂-CO₂H,

-(εK)-(γ-Glu)-CO-(CH₂)₁₂-CO₂H,

-(εK)-(γ-Glu)-(γ-Glu)-CO-(CH₂)₁₂-CO₂H,

-(γ-Glu)-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-CO-(CH₂)₁₂-CO₂H,

-(εK)-(εK)-(γ-Glu)-CO-(CH₂)₁₂-CO₂H,

-(γ-Glu)-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-CO-(CH₂)₁₂-CO₂H,

-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(γ-Glu)-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-CO-(CH₂)₁₂-CO₂H,

-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-(7-(4-카르복시페녹시)헵타노일),

-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-(8-(4-카르복시페녹시)옥타노일),

-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(γ-Glu)-(4-(4-tert-부틸페닐)부타노일),

-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-(11-(4-카르복시페녹시)운데카노일),

-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₃-(γ-Glu)-(10-(4-카르복시페녹시)데카노일),

-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-CO-(CH₂)₁₂-CO₂H,

-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(γ-Glu)-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-CO-(CH₂)₁₂-CO₂H,

-PEG3-(γ-Glu)-CO-(CH₂)₁₂-CO₂H,

-PEG4-(γ-Glu)-CO-(CH₂)₁₂-CO₂H,

-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₃-(γ-Glu)-CO-(CH₂)₁₀-CH₃,

-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-(11-(4-카르복시페녹시)운데카노일,

-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-CO-(CH₂)₁₄-CO₂H,

-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-Ahx-(γ-Glu)-CO-(CH₂)₁₂-CO₂H,

-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-Aoc-(γ-Glu)-CO-(CH₂)₁₂-CO₂H,

-Ahx-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(γ-Glu)-CO-(CH₂)₁₂-CO₂H,

-Aoc-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(γ-Glu)-CO-(CH₂)₁₂-CO₂H,

-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-Ahx-(γ-Glu)-(10-(4-카르복시페녹시)데카노일),

-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-Aoc-(γ-Glu)-(10-(4-카르복시페녹시)데카노일),

-Ahx-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(γ-Glu)-(10-(4-카르복시페녹시)데카노일),

-Aoc-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(γ-Glu)-(10-(4-카르복시페녹시)데카노일),

-PEG4-(γ-Glu)-(10-(4-카르복시페녹시)데카노일),

-PEG3-(γ-Glu)-(10-(4-카르복시페녹시)데카노일),

-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-Aoc-CO-(CH₂)₁₂-CO₂H,

-PEG6-(γ-Glu)-CO-(CH₂)₁₂-CO₂H,

-PEG5-(γ-Glu)-CO-(CH₂)₁₂-CO₂H,

-PEG6-(γ-Glu)-(10-(4-카르복시페녹시)데카노일),

-PEG5-(γ-Glu)-(10-(4-카르복시페녹시)데카노일),

-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-Trx-(γ-Glu)-CO-(CH₂)₁₂-CO₂H,

-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-Trx-(γ-Glu)-(10-(4-카르복시페녹시)데카노일),

-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-Trx-(γ-Glu)-CO-(CH₂)₁₂-CO₂H,

-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-Trx-(γ-Glu)-(10-(4-카르복시페녹시)데카노일),

-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)₂-CO-(CH₂)₁₂-CO₂H,

-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)₂-(10-(4-카르복시페녹시)데카노일),

-(γ-Glu)-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-CO-(CH₂)₁₂-CO₂H,

-(γ-Glu)-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-(10-(4-카르복시페녹시)데카노일),

-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(γ-Glu)-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(γ-Glu)-CO-(CH₂)₁₂-CO₂H, 및

-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(γ-Glu)-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(γ-Glu)-(10-(4-카르복시페녹시)데카노일).

-(εK)-(γ-Glu)-CO-(CH₂)₁₂-CO₂H,

-(εK)-(γ-Glu)-(γ-Glu)-CO-(CH₂)₁₂-CO₂H,

-(εK)-(εK)-(γ-Glu)-CO-(CH₂)₁₂-CO₂H,

-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-(8-(4-카르복시페녹시)옥타노일), 및

-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(γ-Glu)-(4-(4-tert-부틸페닐)부타노일).

-(εK)-(γ-Glu)-CO-(CH₂)₁₂-CO₂H,

-(εK)-(γ-Glu)-(γ-Glu)-CO-(CH₂)₁₂-CO₂H,

-(εK)-(εK)-(γ-Glu)-CO-(CH₂)₁₂-CO₂H,

R₅가 하기로 이루어진 군으로부터 선택된 것인 화학식 I의 화합물 또는 그의 제약상 허용되는 염이 제공된다:

-CO-(CH₂)₁₂-CO₂H, -CO-(CH₂)₁₀-CO₂H, -(10-(4-카르복시페녹시)데카노일), -(4-(4-아이오도페닐)부타노일), -(4-(4-tert-부틸페닐)부타노일), -CO-(CH₂)₁₄-CH₃, -CO-(CH₂)₁₂-CH₃,-CO-(CH₂)₁₀-CH₃, -(7-(4-카르복시페녹시)헵타노일), -(8-(4-카르복시페녹시)옥타노일), (11-(4-카르복시페녹시)운데카노일), -(12-(4-카르복시페녹시)도데카노일), 및 CO-(CH₂)₁₄-CO₂H.

-CO-(CH₂)₁₂-CO₂H, -CO-(CH₂)₁₀-CO₂H, -(10-(4-카르복시페녹시)데카노일), -(4-(4-아이오도페닐)부타노일), -(4-(4-tert-부틸페닐)부타노일), -CO-(CH₂)₁₄-CH₃, -CO-(CH₂)₁₂-CH₃,-CO-(CH₂)₁₀-CH₃, -(7-(4-카르복시페녹시)헵타노일), 및 -(8-(4-카르복시페녹시)옥타노일).

R₄가 하기로 이루어진 군으로부터 선택된 것인 화학식 I의 화합물 또는 그의 제약상 허용되는 염이 제공된다:

-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-,

-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-,

-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(γ-Glu)-,

-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)₂)-,

-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₃-(γ-Glu)-,

-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(εK)-,

-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(εK)-(γ-Glu)-,

-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(εK)-(γ-Glu)-,

-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-Trx-(γ-Glu)-,

-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-Trx-(γ-Glu)-,

-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-Aoc-,

-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-Aoc-(γ-Glu)-,

-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-Ahx-(γ-Glu)-,

-PEG3-(γ-Glu)-,

-PEG4-(γ-Glu)-,

-PEG5-(γ-Glu)-,

-PEG6-(γ-Glu)-,

-Ahx-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(γ-Glu)-,

-Aoc-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(γ-Glu)-,

-(εK)-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(γ-Glu)-,

-(εK)-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-,

-(εK)-(γ-Glu)-,

-(εK)-(γ-Glu)-(γ-Glu)-,

-(γ-Glu)-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-,

-(εK)-(εK)-(γ-Glu)-,

-(γ-Glu)-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-,

-(γ-Glu)-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-,

-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(γ-Glu)-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-,

-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-,

-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(γ-Glu)-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-, 및

(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(γ-Glu)-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(γ-Glu)-.

-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-,

-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-,

-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(γ-Glu)-,

-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₃-(γ-Glu)-,

-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(εK)-,

-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(εK)-(γ-Glu)-,

-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(εK)-(γ-Glu)-,

-(εK)-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(γ-Glu)-,

-(εK)-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-,

-(εK)-(γ-Glu)-,

-(εK)-(γ-Glu)-(γ-Glu)-,

-(γ-Glu)-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-,

-(εK)-(εK)-(γ-Glu)-,

-(γ-Glu)-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-, 및

-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(γ-Glu)-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-.

X₁₇ 및 X₃₁이 각각 KZ₁인 화학식 I의 화합물 또는 그의 제약상 허용되는 염이 제공된다. X₁₇ 및 X₂₄가 각각 KZ₁인 화학식 I의 화합물 또는 그의 제약상 허용되는 염이 제공된다. X₁₇ 및 X₂₁이 각각 KZ₁인 화학식 I의 화합물 또는 그의 제약상 허용되는 염이 제공된다. X₁₇ 및 X₂₈이 각각 KZ₁인 화학식 I의 화합물 또는 그의 제약상 허용되는 염이 제공된다. X₁₇ 및 X₄₀이 각각 KZ₁인 화학식 I의 화합물 또는 그의 제약상 허용되는 염이 제공된다. X₂₁ 및 X₄₀이 각각 KZ₁인 화학식 I의 화합물 또는 그의 제약상 허용되는 염이 제공된다. X₂₁ 및 X₂₈이 각각 KZ₁인 화학식 I의 화합물 또는 그의 제약상 허용되는 염이 제공된다. X₂₄ 및 X₂₈이 각각 KZ₁인 화학식 I의 화합물 또는 그의 제약상 허용되는 염이 제공된다.

X₁이 Y이고; X₆이 αMeF(2F)이고; X₁₀이 4Pal, Y, 및 KZ₁로 이루어진 군으로부터 선택되고; X₁₁이 S, αMeS, 및 Aib로 이루어진 군으로부터 선택되고; X₁₂가 I이고; X₁₃이 αMeL이고; X₁₆이 Orn이고; X₁₇이 I 및 KZ₁로 이루어진 군으로부터 선택되고; X₂₀이 Aib이고; X₂₁이 KZ₁ 및 E로 이루어진 군으로부터 선택되고; X₂₂가 F 및 αMeF로 이루어진 군으로부터 선택되고; X₂₄가 D-Glu 및 KZ₁로 이루어진 군으로부터 선택되고; X₂₅가 αMeY이고; X₂₈이 E 및 KZ₁로 이루어진 군으로부터 선택되고; X₃₀이 G 및 GR₂로 이루어진 군으로부터 선택되고; R₂가 X₃₁SSGX₃₅PPPX₃₉ (서열식별번호: 7), X₃₁SSGX₃₅PPPX₃₉R₃ (서열식별번호: 8), 및 X₃₁SSGX₃₅PPPX₃₉X₄₀ (서열식별번호: 9), 및 변형이 NH₂인 c-말단 기의 변형으로 이루어진 군으로부터 선택되고; X₃₁이 P 및 KZ₁로 이루어진 군으로부터 선택되고; X₃₅가 A 및 Orn으로 이루어진 군으로부터 선택되고; X₃₉가 S, Orn으로 이루어진 군으로부터 선택되고; X₄₀이 KZ₁로 이루어진 군으로부터 선택되고; R₃이 변형이 NH₂인 C-말단 기의 변형이고; 여기서 X₁₀, X₁₇, X₂₁, X₂₄, X₂₈, 및 X₃₁로 이루어진 군으로부터 선택된 1개, 및 오직 1개가 KZ₁이고; Z₁이 -R₄R₅이고; R₄가 링커이고; R₅가 지방산인 화학식 I의 화합물 또는 그의 제약상 허용되는 염이 제공된다.

하기로 이루어진 군으로부터 선택된 화학식 I의 화합물 또는 그의 제약상 허용되는 염이 제공된다:

Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-CO-(CH₂)₁₂-CO₂H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-CO-(CH₂)₁₂-CO₂H)SSGAPPPS-NH₂,

Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-(10-(4-카르복시페녹시)데카노일))AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-(10-(4-카르복시페녹시)데카노일))SSGAPPPS-NH₂,

Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-(4-(4-아이오도페닐)부타노일))AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-(4-(4-아이오도페닐)부타노일))SSGAPPPS-NH₂,

Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-(4-(4-tert-부틸페닐)부타노일))AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-(4-(4-tert-부틸페닐)부타노일))SSGAPPPS-NH₂, 및

Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-CO-(CH₂)₁₀-CH₃)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-CO-(CH₂)₁₀-CH₃)SSGAPPPS-NH₂.

한 실시양태에서, R₄ 링커는 εK 및 γ-Glu로 이루어진 군으로부터 선택된 1 내지 2개의 아미노산이다. 한 실시양태에서, R₄ 링커는 1 내지 3개의 (2-[2-(2-아미노-에톡시)-에톡시]-아세틸) 모이어티를 포함한다. 한 실시양태에서, R₅ 지방산 모이어티는 리신과 R₅ 지방산 사이의 R₄ 링커를 통해 리신에 접합된다.

한 실시양태는 R₄ 링커가 0 내지 4개의 아미노산; 및 0 내지 3개의 (2-[2-(2-아미노-에톡시)-에톡시]-아세틸) 모이어티를 포함하는 것인, 화학식 I의 화합물 또는 그의 제약상 허용되는 염이다. 한 실시양태에서, R₄ 링커는 εK 및 γ-Glu로 이루어진 군으로부터 각각 독립적으로 선택된 1 내지 3개의 아미노산을 포함한다. 한 실시양태는 R₄ 링커가 εK 및 γ-Glu로 이루어진 군으로부터 각각 독립적으로 선택된 1 내지 2개의 아미노산을 포함하는 것인, 화학식 I의 화합물 또는 그의 제약상 허용되는 염이다. 한 실시양태는 2개의 Z₁ 지방산 모이어티를 포함하며, 여기서 Z₁ 모이어티의 각각의 R₅ 지방산은 R₄ 링커를 통해 펩티드의 상이한 리신에 접합되고, 여기서 R₄ 링커는 0 내지 2개의 γ-Glu 아미노산 잔기를 포함하는 것인, 화학식 I의 화합물 또는 그의 제약상 허용되는 염이다. 한 실시양태는 2개의 Z₁ 지방산 모이어티를 포함하며, 여기서 Z₁의 각각의 R₅ 지방산은 R₄ 링커를 통해 펩티드의 상이한 리신에 접합되고, 여기서 R₄는 1 내지 3개의 아미노산 및 1 내지 3개의 (2-[2-(2-아미노-에톡시)-에톡시]-아세틸) 모이어티를 포함하는 것인, 화학식 I의 화합물 또는 그의 제약상 허용되는 염이다. 한 실시양태는 2개의 동일한 Z₁ 지방산 모이어티를 포함하며, 여기서 Z₁의 R₅ 지방산은 각각 R₄ 링커를 통해 펩티드의 상이한 리신에 접합되고, 여기서 R₄는 εK 및 γ-Glu로 이루어진 군으로부터 각각 독립적으로 선택된 1 내지 3개의 아미노산; 및 아미노산에 부착된 1 내지 3개의 (2-[2-(2-아미노-에톡시)-에톡시]-아세틸) 모이어티를 포함하는 것인, 화학식 I의 화합물 또는 그의 제약상 허용되는 염이다. 한 실시양태는 2개의 동일한 Z₁ 지방산 모이어티를 포함하며, 여기서 Z₁의 R₅ 지방산은 각각 R₄ 링커를 통해 펩티드의 상이한 리신에 접합되고, 여기서 R₄는 1 또는 2개의 (2-[2-(2-아미노-에톡시)-에톡시]-아세틸) 모이어티에 부착된 γ-Glu 및 εK로 이루어진 군으로부터 각각 독립적으로 선택된 최대 3개의 아미노산을 포함하는 것인, 화학식 I 화합물 또는 그의 제약상 허용되는 염이다.

한 실시양태는 2개의 동일한 Z₁ 지방산 모이어티를 포함하며, 여기서 Z₁의 R₅ 지방산은 각각 R₄ 링커를 통해 접합되고, 여기서 R₄ 링커는 하기 화학식: -(εK)_a1-(γ-Glu)_a2-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)_a3-(εK)_b1-(γ-Glu)_b2-를 갖고; 여기서 a1은 0, 1, 및 2로 이루어진 군으로부터 선택되고; a2는 0, 1, 및 2로 이루어진 군으로부터 선택되고; a3은 0, 1, 2, 및 3으로 이루어진 군으로부터 선택되고; b1은 0 또는 1이고; b2는 0 또는 1인, 화학식 I 화합물 또는 그의 제약상 허용되는 염이다. 한 실시양태는 2개의 동일한 Z₁ 지방산 모이어티를 포함하며, 여기서 Z₁의 R₅ 지방산은 각각 R₄ 링커를 통해 접합되고, 여기서 Z₁은 화학식: -(εK)_a1-(γ-Glu)_a2-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)_a3-(εK)_b1-(γ-Glu)_b2-CO-(CH₂)_q-CO₂H를 갖고, 여기서 a1은 0, 1, 및 2로 이루어진 군으로부터 선택되고; a2는 0, 1, 및 2로 이루어진 군으로부터 선택되고; a3은 0, 1, 2, 및 3으로 이루어진 군으로부터 선택되고; b1은 0 또는 1이고; b2는 0 또는 1이고; q는 10, 12, 14 및 16으로 이루어진 군으로부터 선택된 것인, 화학식 I 화합물 또는 그의 제약상 허용되는 염이다.

한 실시양태에서, a1은 1이고, a2는 0이고, a3은 2이고, b1은 0이고, b2는 1이고, q는 12이고; 구조는

-(εK)-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-CO-(CH₂)₁₂-CO₂H이다.

한 실시양태는 2개의 동일한 Z₁ 지방산 모이어티를 포함하며, 여기서 Z₁의 R₅ 지방산은 각각 R₄ 링커를 통해 접합되고, 여기서 R₄ 링커 및 R₅ 지방산 성분은 하기 화학식:

을 갖고, 여기서 q2는 7, 8, 10, 11, 및 12로 이루어진 군으로부터 선택된 것인, 화학식 I 화합물 또는 그의 제약상 허용되는 염이다.

한 실시양태는 2개의 동일한 Z₁ 지방산 모이어티를 포함하며, 여기서 Z₁의 R₅ 지방산은 각각 R₄ 링커를 통해 접합되고, 여기서 R₅ 지방산은 -(7-(4-카르복시페녹시)헵타노일) 및 -(8-(4-카르복시페녹시)옥타노일)로 이루어진 군으로부터 선택된 것인, 화학식 I 화합물 또는 그의 제약상 허용되는 염이다. 한 실시양태는 R₄ 링커를 통해 각각 접합된 2개의 동일한 Z₁ 지방산 모이어티를 포함하며, 여기서 R₅ 지방산은 -(10-(4-카르복시페녹시)데카노일), -(4-(4-아이오도페닐)부타노일), 및-(4-(4-tert-부틸페닐)부타노일)로 이루어진 군으로부터 선택된 것인, 화학식 I 화합물 또는 그의 제약상 허용되는 염이다.

한 실시양태는 R₄ 링커를 통해 각각 접합된 2개의 동일한 Z₁ 지방산 모이어티를 포함하며, 여기서 R₅ 지방산은 -CO-(CH₂)₁₄-CH₃, -CO-(CH₂)₁₂-CH₃, 및 -CO-(CH₂)₁₀-CH₃으로 이루어진 군으로부터 선택된 것인, 화학식 I 화합물 또는 그의 제약상 허용되는 염이다.

한 실시양태는 R₄ 링커를 통해 각각 접합된 2개의 동일한 Z₁ 지방산 모이어티를 포함하며, 여기서 R₅ 지방산은 -CO-(CH₂)₁₂-CO₂H 및 -CO-(CH₂)₁₀-CO₂H로 이루어진 군으로부터 선택된 것인, 화학식 I 화합물 또는 그의 제약상 허용되는 염이다. 한 실시양태는 R₄ 링커를 통해 각각 접합된 2개의 동일한 Z₁ 지방산 모이어티를 포함하며, 여기서 R₅ 지방산은 -CO-(CH₂)₁₀-CH₃및 -CO-(CH₂)₁₂-CH₃으로 이루어진 군으로부터 선택된 것인, 화학식 I 화합물 또는 그의 제약상 허용되는 염이다.

한 실시양태에서, R₅ 지방산은 -CO-(CH₂)₁₂-CO₂H, -CO-(CH₂)₁₀-CO₂H, -(10-(4-카르복시페녹시)데카노일), -(4-(4-아이오도페닐)부타노일), -(4-(4-tert-부틸페닐)부타노일), -CO-(CH₂)₁₄-CH₃,-CO-(CH₂)₁₂-CH₃, -CO-(CH₂)₁₀-CH₃, -(7-(4-카르복시페녹시)헵타노일), 및 -(8-(4-카르복시페녹시)옥타노일)로 이루어진 군으로부터 선택된다.

한 실시양태는 T2DM, 비만, 비알콜성 지방간 질환 (NAFLD), 비알콜성 지방간염 (NASH), 이상지혈증 및 대사 증후군으로 이루어진 군으로부터 선택된 상태의 치료를 필요로 하는 대상체에게 유효량의 화학식 I의 화합물 또는 그의 제약상 허용되는 염을 투여하는 것을 포함하는, 상기 상태를 치료하는 방법을 제공한다. 한 실시양태는 치료적 체중 감소의 제공을 필요로 하는 대상체에게 유효량의 화학식 I의 화합물 또는 그의 제약상 허용되는 염을 투여하는 것을 포함하는, 치료적 체중 감소를 제공하는 방법을 제공한다. 한 실시양태에서, 상태는 NAFLD이다. 한 실시양태에서, 상태는 NASH이다.

한 실시양태는 요법에 사용하기 위한 화학식 I의 화합물 또는 그의 제약상 허용되는 염을 제공한다. 한 실시양태는 T2DM, 비만, NAFLD, NASH, 이상지혈증, 및 대사 증후군으로 이루어진 군으로부터 선택된 상태의 치료에 사용하기 위한 화학식 I의 화합물 또는 그의 제약상 허용되는 염을 제공한다. 한 실시양태에서, 상태는 T2DM이다. 한 실시양태에서, 상태는 비만이다. 한 실시양태에서, 상태는 NAFLD이다. 한 실시양태에서, 상태는 NASH이다. 한 실시양태에서, 상태는 대사 증후군이다.

화학식 I의 화합물 또는 그의 제약상 허용되는 염은 다양한 증상 또는 장애의 치료에 유용할 수 있다. 예를 들어, 특정 실시양태는 T2DM의 치료를 필요로 하는 대상체에게 유효량의 화학식 I의 화합물 또는 그의 제약상 허용되는 염을 투여하는 것을 포함하는, 환자에서 T2DM을 치료하는 방법을 제공한다. 한 실시양태는 비만의 치료를 필요로 하는 대상체에게 유효량의 화학식 I의 화합물 또는 그의 제약상 허용되는 염을 투여하는 것을 포함하는, 환자에서 비만을 치료하는 방법이다. 한 실시양태에서, 방법은 대상체에서 비-치료적 체중 감소를 유도하는 것이며, 이러한 치료를 필요로 하는 대상체에게 유효량의 화학식 I의 화합물 또는 그의 제약상 허용되는 염을 투여하는 것을 포함한다.

특정 실시양태에서, 본 발명은 대사 증후군의 치료를 필요로 하는 대상체에게 유효량의 화학식 I의 화합물 또는 그의 제약상 허용되는 염을 투여하는 것을 포함하는, 환자에서 대사 증후군을 치료하는 방법을 제공한다. 한 실시양태에서, 방법은 NASH의 치료를 필요로 하는 대상체에게 유효량의 화학식 I의 화합물 또는 그의 제약상 허용되는 염을 투여하는 것을 포함하는, NASH의 치료이다.

또한, T2DM, 비만, NAFLD, NASH, 이상지혈증 및 대사 증후군으로 이루어진 군으로부터 선택된 상태의 치료에서 메트포르민, 티아졸리딘디온, 술포닐우레아, 디펩티딜 펩티다제 4 억제제, 소듐 글루코스 공동수송체, SGLT-2 억제제, 성장 분화 인자 15 조정제 ("GDF15"), 펩티드 티로신 티로신 조정제 ("PYY"), 변형된 인슐린, 아밀린, 이중 아밀린 칼시토닌 수용체 효능제 및 옥신토모듈린 효능제 ("OXM")로부터 선택된 1종 이상의 작용제와 동시, 개별 및 순차적 조합으로 사용하기 위한 본 발명의 화합물이 본원에 제공된다. 한 실시양태에서, 본 발명의 화합물은 메트포르민, 티아졸리딘디온, 술포닐우레아, 디펩티딜 펩티다제 4 억제제, 소듐 글루코스 공동수송체, SGLT-2 억제제, GDF15, PYY, 변형된 인슐린, 아밀린, 이중 아밀린 칼시토닌 수용체 효능제 및 OXM으로부터 선택된 1종 이상의 작용제와 고정 용량 조합물로 제공된다. 한 실시양태는 T2DM 및 비만으로 이루어진 군으로부터 선택된 상태의 치료에서 메트포르민, 티아졸리딘디온, 술포닐우레아, 디펩티딜 펩티다제 4 억제제, 소듐 글루코스 공동수송체, SGLT-2 억제제, GDF15, PYY, 변형된 인슐린, 아밀린, 이중 아밀린 칼시토닌 수용체 효능제, 및 OXM으로부터 선택된 1종 이상의 작용제와 동시, 개별 및 순차적 조합으로 사용하기 위한 본 발명의 화합물이다. 한 실시양태는 T2DM 및 비만으로 이루어진 군으로부터 선택된 상태의 치료에서 메트포르민, 티아졸리딘디온, 술포닐우레아, 디펩티딜 펩티다제 4 억제제, 소듐 글루코스 공동수송체, 및 SGLT-2 억제제로부터 선택된 1종 이상의 작용제와 동시, 개별 및 순차적 조합으로 사용하기 위한 본 발명의 화합물이다.

다른 실시양태에서, 화합물 또는 그의 제약상 허용되는 염은 골 강도의 개선을 필요로 하는 대상체에서 골 강도를 개선시키는데 유용할 수 있다. 본 발명의 화합물 또는 그의 제약상 허용되는 염은 다른 장애, 예컨대 파킨슨병 또는 알츠하이머병의 치료에 유용할 수 있다. GIP, GLP-1 및/또는 글루카곤 수용체 중 1종 이상에서 활성을 갖는 인크레틴 및 인크레틴 유사체는, 예를 들어 비만, NAFLD 및 NASH, 이상지질혈증, 대사 증후군, 골 관련 장애, 알츠하이머병, 및 파킨슨병을 포함한 다수의 다른 질환 또는 상태에서 치료 가치를 가질 잠재력을 갖는 것으로 기재되었다. 예를 들어, 문헌 [Jall S., et. al, Monomeric GLP-1/GIP/glucagon triagonism corrects obesity, hepatosteatosis, and dyslipidemia in female mice, Mol. Metab. 6(5):440-446 (March 2017); Carbone L.J., et. al., Incretin-based therapies for the treatment of non-alcoholic fatty liver disease: A systematic review and meta-analysis. J.Gastroenterol. Hepatol., 31(1):23-31 (Jan. 2016); B. Finan, et. al, Reappraisal of GIP Pharmacology for Metabolic Diseases. Trends Mol. Med., 22(5):359-76 (May 2016); Choi, I.Y., et al., Potent body weight loss and efficacy in a NASH animal model by a novel long-acting GLP-1/Glucagon/GIP triple-agonist (HM15211), ADA 2017 Poster 1139-P; Ding, K.H., Impact of glucose-dependent insulinotropic peptide on age-induced bone loss, J. Bone Miner. Res., 23(4):536-43 (2008); Tai, J. et. al, Neuroprotective effects of a triple GLP-1/GIP/glucagon receptor agonist in the APP/PS1 transgenic mouse model of Alzheimer's disease, Brain Res. 1678, 64-74 (2018); T.D. Mueller et al., The New Biology and Pharmacology of Glucagon, Physiol. Rev. 97: 721-766 (2017); Finan, B. et. al, Unimolecular Dual Incretins Maximize Metabolic Benefits in Rodents, Monkeys, and Humans, Sci. Transl. Med., 5:209 (October 2013); Hoelscher C, Insulin, incretins and other growth factors as potential novel treatments for Alzheimer's and Parkinson's diseases. Biochem. Soc. Trans. 42(2):593-0 (Apr. 2014)]을 참조한다.

또 다른 실시양태는 T2DM, 비만, NAFLD, NASH, 이상지혈증 및 대사 증후군으로 이루어진 군으로부터 선택된 상태의 치료를 위한 의약의 제조에서의 본 발명의 화합물 또는 그의 제약상 허용되는 염의 용도를 제공한다. 한 실시양태에서, 의약은 T2DM의 치료를 위한 것이다. 한 실시양태에서, 의약은 비만의 치료를 위한 것이다. 한 실시양태에서, 의약은 NAFLD의 치료를 위한 것이다. 한 실시양태에서, 의약은 NASH의 치료를 위한 것이다.

또 다른 실시양태는 화학식 I의 화합물 또는 그의 제약상 허용되는 염, 및 담체, 희석제, 및 부형제로 이루어진 군으로부터 선택된 적어도 1종을 포함하는 제약 조성물을 제공한다.

본원에 사용된 용어 "치료하는" 또는 "치료하는 것"은 증상, 상태, 또는 장애의 진행 또는 중증도를 저지, 둔화, 정지, 또는 역전시키는 것을 포함한다.

본원에 제공된 특정 화합물은 일반적으로 넓은 투여량 범위에 걸쳐 효과적이다. 예를 들어, 매주 1회 비경구 투여를 위한 투여량은 1주에 1인당 0.05 mg 내지 약 30 mg의 범위 내에 속할 수 있다. 본원에 제공된 화합물은 경구로 이용가능하고, 경구 제제화 기술을 사용하여 투여될 수 있다. 경구 제제는 예컨대 매일 1회의 주기적 투여를 위해 제제화될 수 있다.

본 발명의 화합물은 각각의 GLP-1 및 GIP 수용체에 대해 친화도를 가지며 이들 수용체 각각에서 목적하는 효력을 갖는 신규 아미노산 서열을 포함한다. GLP-1은 36개 아미노산의 펩티드이며, 그의 주요 생물학적 활성 단편은 30-개 아미노산의 C-말단 아미드화된 펩티드 (GLP-1_7-36) (서열식별번호: 2)로서 생산된다.

GIP는, GLP-1과 마찬가지로, 또한 인크레틴으로도 공지되어 있으며, 글루코스의 존재 하에 췌장 베타 세포로부터의 인슐린 분비를 자극함으로써 글루코스 항상성에서 생리학적 역할을 하는 42개 아미노산 펩티드 (서열식별번호: 1)이다.

화합물은 GIP 및 GLP-1 수용체 각각에서 목적하는 효력을 제공한다. 한 실시양태에서, 화합물은 경구 투여에 적합하다. 한 실시양태에서, 화합물은 바람직한 GIP 및 GLP 수용체 연장된 시간 작용을 갖는다.

본원에 사용된 "링커"는 R₅ 지방산을 펩티드의 리신에 접합시키는 기를 의미한다. 본원에 사용된 "지방산"은 카르복실 기를 갖는 탄화수소를 의미한다. 본원에 사용된 "Ac"는 아세틸 변형을 의미한다. 한 실시양태에서, 지방산은 알부민 결합 기이다. 본원에 사용된 용어 "아미노산"은 자연 발생 아미노산 및 비천연 아미노산 둘 다를 의미한다. 아미노산은 전형적으로 표준 1 문자 코드 (예를 들어, L = 류신), 뿐만 아니라 천연 아미노산의 알파-메틸 치환된 잔기 (예를 들어, α-메틸 류신, 또는 αMeL 및 α-메틸 리신, 또는 αMeK) 및 특정 다른 비천연 아미노산, 예컨대 알파 아미노 이소부티르산, 또는 "Aib", "4Pal", "Orn" 등을 사용하여 도시된다. 비-천연 아미노산 및 다른 약어의 구조를 하기 제시한다:

본원에 사용된 "Orn"은 오르니틴을 의미한다. 본원에 사용된 "4Pal"은 3-(4-피리딜)-L-알라닌을 의미한다. 본원에 사용된 "αMeF(2F)"는 알파-메틸 2-F-페닐알라닌, 알파-메틸-F(2F), 및 알파-메틸-Phe(2F)를 의미한다. 본원에 사용된 "αMeY"는 알파 메틸 티로신, 알파 메틸-Tyr, 및 알파 메틸-Y를 의미한다. 본원에 사용된 "αMeL"은 알파 메틸 류신, 알파 메틸-L, 및 알파 메틸-Leu를 의미한다. 본원에 사용된 "e" 및 "D-Glu"는 D-글루탐산을 의미한다. 본원에 사용된 "αMeF"는 알파-메틸-F 및 알파-메틸-Phe를 의미한다. 본원에 사용된 "αMeS"는 알파-메틸-세린, 알파 메틸-S, 및 알파-메틸-Ser을 의미한다. 본원에 사용된 "AEEA"는 (2-[2-(2-아미노-에톡시)-에톡시]-아세틸)을 의미하고; "AEEA2"는 (2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂를 의미하고; "AEEA3"은 (2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₃을 의미한다.

본원에 사용된 "Ahx"는 6-아미노헥사노일-이고; "Aoc"는 8-아미노옥타노일-이고; "PEG3"은 [3-(2-[2-(2-아미노-에톡시)-에톡시]-에톡시)-프로파노일]-이고; "PEG4"는 (3-[2-(2-[2-(2-아미노-에톡시)-에톡시]-에톡시)-에톡시]-프로파노일)-이고; "PEG5"는 [3-(2-[2-(2-[2-(2-아미노-에톡시)-에톡시]-에톡시)-에톡시]-에톡시)-프로파노일]-이고; "PEG6"은 (3-[2-(2-[2-(2-[2-(2-아미노-에톡시)-에톡시]-에톡시)-에톡시]-에톡시)-에톡시]-프로파노일)-이다. "Tle"는 tert-류신이다.

하기 실시예의 화학 구조에 제시된 바와 같이, 한 실시양태에서 상기 기재된 링커-지방산 모이어티 (-R₅R₄)는 리신 측쇄의 엡실론-아미노 기에 연결된다.

GIP 또는 GLP-1 수용체 중 1종 이상과 관련하여 본원에 사용된 경우에, 용어 "활성", "활성화하다", "활성화하는" 등은 관련 기술분야에 공지된 검정, 예컨대 하기 기재된 시험관내 검정을 사용하여 측정된 바와 같이, 수용체(들)에 결합하고 그에서 반응을 유도하는 화합물 또는 그의 제약상 허용되는 염의 능력을 지칭한다.

각각의 GIP 및 GLP-1 수용체에 대한 본 발명의 화합물 또는 그의 제약상 허용되는 염의 친화도는, 예를 들어 하기 실시예에 기재된 것을 포함한 관련 기술분야에서 수용체 결합 수준을 측정하는 것으로 공지된 기술을 사용하여 측정될 수 있고, 이는 통상적으로 Ki 값으로 표현된다. 각각의 수용체에서의 본 발명의 화합물의 활성은 또한, 예를 들어 하기 기재된 시험관내 활성 검정을 포함한 관련 기술분야에 공지된 기술을 사용하여 측정될 수 있고, 이는 통상적으로 EC₅₀ 값으로서 표현되며, 이는 용량 반응 곡선에서 반수-최대 시뮬레이션을 유발하는 화합물의 농도이다.

한 실시양태에서, 화학식 I의 화합물의 제약 조성물은 비경구 경로 (예를 들어, 피하, 정맥내, 복강내, 근육내, 또는 경피)에 의한 투여에 적합하다. 한 실시양태에서, 화학식 I의 화합물의 제약 조성물은 경구 투여에 적합하다 (예를 들어, 정제, 캡슐). 일부 제약 조성물 및 그의 제조 방법은 관련 기술분야에 널리 공지되어 있다. (예를 들어, 문헌 [Remington: The Science and Practice of Pharmacy (D.B. Troy, Editor, 21st Edition, Lippincott, Williams & Wilkins, 2006] 참조).

본원에 제공된 화합물은 다수의 무기 및 유기 산/염기와 반응하여 제약상 허용되는 산/염기 부가염을 형성할 수 있다. 제약상 허용되는 염 및 이를 제조하기 위한 통상의 방법론은 관련 기술분야에 널리 공지되어 있다. (예를 들어, 문헌 [P. Stahl, et al., Handbook of Pharmaceutical Salts: Properties, Selection and Use, 2nd Revised Edition (Wiley-VCH, 2011)] 참조). 본 발명의 제약상 허용되는 염은 나트륨, 트리플루오로아세테이트, 히드로클로라이드, 암모늄, 및 아세테이트 염을 포함하나, 이에 제한되지는 않는다. 한 실시양태에서, 제약상 허용되는 염은 나트륨, 히드로클로라이드, 및 아세테이트 염으로 이루어진 군으로부터 선택된다.

본 발명은 또한 본 발명의 화합물 또는 그의 제약상 허용되는 염의 합성에 유용한 신규 중간체 및 방법을 포괄한다. 본 발명의 중간체 및 화합물은 관련 기술분야에 공지된 다양한 절차에 의해 제조될 수 있다. 특히, 하기 실시예는 화학적 합성을 사용한 방법을 기재한다. 기재된 각각의 경로에 대한 구체적 합성 단계는 본 발명의 화합물을 제조하기 위해 상이한 방식으로 조합될 수 있다. 시약 및 출발 물질은 관련 기술분야의 통상의 기술자에게 용이하게 입수가능하다.

본원에 사용된 용어 "유효량"은 환자에게 단일 또는 다중 용량 투여 시, 진단 또는 치료 하에 있는 환자에서 목적하는 효과를 제공하는, 본원에 제공된 화합물 또는 그의 제약상 허용되는 염의 양 또는 용량을 지칭한다. 유효량은 공지된 기술을 사용하여 및 유사한 상황 하에 수득된 결과를 관찰함으로써 관련 기술분야의 통상의 기술자에 의해 결정될 수 있다. 대상체에 대한 유효량을 결정하는데 있어서, 포유동물의 종; 그의 크기, 연령, 및 전반적 건강; 침범된 구체적 질환 또는 장애; 질환 또는 장애의 침범 정도 또는 중증도; 개별 환자의 반응; 투여되는 특정한 화합물; 투여 방식; 투여되는 제제의 생체이용률 특징; 선택된 용량 요법; 병용 의약의 사용; 및 다른 관련 상황을 포함하나 이에 제한되지는 않는 다수의 인자가 고려된다.

본원에 사용된 용어 "이를 필요로 하는 대상체"는, 예를 들어 상기 단락에 열거된 것을 포함한, 치료 또는 요법을 필요로 하는 질환 또는 상태를 갖는 포유동물, 바람직하게는 인간을 지칭한다. 본원에 사용된 "EDTA"는 에틸렌디아민테트라아세트산을 의미한다. 본원에 사용된 "DMSO"는 디메틸 술폭시드를 의미한다. 본원에 사용된 "CPM"은 분당 카운트를 의미한다. 본원에 사용된 "IBMX"는 3-이소부틸-1-메틸크산틴을 의미한다. 본원에 사용된 "LC/MS"는 액체 크로마토그래피/질량 분광측정법을 의미한다. 본원에 사용된 "HTRF"는 균질 시간-분해 형광을 의미한다. 본원에 사용된 "BSA"는 소 혈청 알부민을 의미한다.

본 발명은 하기 실시예에 의해 추가로 예시되며, 이는 제한하는 것으로 해석되어서는 안된다.

펩티드 합성

실시예 1

Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-CO-(CH₂)₁₂-CO₂H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-CO-(CH₂)₁₂-CO₂H)SSGAPPPS-NH₂ (서열식별번호: 11).

서열식별번호: 11의 구조는 잔기 Aib2, αMeF(2F)6, 4Pal10, αMeL13, Orn16, K17, Aib20, D-Glu24, αMeY25, K31 및 Ser39를 제외하고, 표준 단일 문자 아미노산 코드를 사용하여 하기에 도시되며, 여기서 이들 아미노산 잔기의 구조는 확장되었다:

실시예 1의 펩티드 백본을 심포니 멀티플렉스 펩티드 합성기 (기로스 프로테인 테크놀로지스(Gyros Protein Technologies), 애리조나주 투산) 상에서 플루오레닐메틸옥시카르보닐 (Fmoc)/tert-부틸 (t-Bu) 화학을 사용하여 합성하였다.

수지는 0.35 mmol/g의 치환으로 1% DVB 가교된 폴리스티렌 (Fmoc-Rink-MBHA 저 로딩 수지, 100-200 메쉬, 이엠디 밀리포어(EMD Millipore))으로 이루어졌다. 표준 측쇄 보호기를 사용하였다. Fmoc-Lys(Mtt)-OH는 위치 17 및 31에서 리신 잔기에 대해 사용되었고, Boc-Tyr(tBu)-OH는 위치 1에서 티로신 잔기에 대해 사용되었다. Fmoc 기를 각각의 커플링 단계 (2 x 7분) 전에 DMF 중 20% 피페리딘을 사용하여 제거하였다. 모든 표준 아미노산 커플링은 이론적 펩티드 로딩에 비해 9-배 몰 과량으로 동등한 몰비의 Fmoc 아미노산 (DMF 중 0.3 mM), 디이소프로필카르보디이미드 (DCM 중 0.9 mM) 및 옥시마 (DMF 중 0.9 mM)를 사용하여 1시간 동안 수행하였다. 예외는 Cα-메틸화된 아미노산에 대한 커플링으로, 이는 3시간 동안 커플링시켰다. 펩티드 백본의 합성이 완결된 후, 수지를 DCM으로 완전히 세척하여 잔류 DMF를 제거하였다. 위치 17 및 31의 리신 잔기 상의 Mtt 보호기를 DCM 중 30% 헥사플루오로이소프로판올 (오크우드 케미칼스(Oakwood Chemicals))을 사용하여 펩티드 수지로부터 선택적으로 제거하고 (3 x 1시간 처리), 수지를 DCM 및 DMF로 완전히 세척하였다.

링커 모이어티의 후속 부착은 표준 커플링 및 탈보호 반응에 대해 상기 기재된 절차에 따라 2-[2-(2-Fmoc-아미노-에톡시)-에톡시]-아세트산 (Fmoc-AEEA-OH, 켐펩, 인크.(ChemPep, Inc.)) 및 Fmoc-글루탐산 α-t-부틸 에스테르 (Fmoc-Glu-OtBu, 아크 팜, 인크.(Ark Pharm, Inc.))의 단계적 커플링에 의해 달성하였다. 최종 Fmoc 보호기의 제거 후, 모노-OtBu-테트라데칸디온산 (욱시 앱텍(WuXi AppTec), 중국 상하이)을 1:1 DCM/DMF 중 4-배 과량의 지방산, 디이소프로필카르보디이미드, 및 옥시마 (1: 1 :1 mol/mol/mol)를 사용하여 밤새 커플링시켰다. 합성이 완결된 후, 펩티드-수지를 DCM으로 세척한 다음, 진공 하에 완전히 건조시켰다.

건조 수지를 실온에서 2시간 동안 10 mL의 절단 칵테일 (트리플루오로아세트산: 물: 트리이소프로필실란, 95:2.5:2.5 v/v)로 처리하였다. 수지를 여과하고, 2 mL의 순수한 T^'FA로 각각 2회 세척하고, 합한 여과물을 5-배 과량의 부피의 차가운 디에틸 에테르 (-20℃)로 처리하여 조 펩티드를 침전시켰다. 이어서, 펩티드/에테르 현탁액을 3500 rpm에서 2분 동안 원심분리하여 고체 펠릿을 형성하고, 상청액을 경사분리하고, 고체 펠릿을 에테르로 추가로 2회 연화처리하고, 진공 하에 건조시켰다. 조 펩티드를 20% 아세토니트릴/20%아세트산/60% 물 20 mL 중에 가용화시키고, 100% 아세토니트릴 및 0.1% TFA/물 완충제 시스템 (60분 내 35-55% 아세토니트릴)의 선형 구배로 시메트리프렙 7 μm C18 정제용 칼럼 (19 x 300 mm, 워터스(Waters)) 상에서 RP-HPLC에 의해 정제하였다. 분석 RP-HPLC를 사용하여 펩티드의 순도를 평가하였고, 풀링 기준은 >95%였다. 실시예 1의 주요 풀 순도는 96.0%인 것으로 확인되었다. 최종 주요 생성물 풀의 후속 동결건조로 동결건조된 펩티드 TFA 염을 수득하였다. 분자량을 LC-MS에 의해 결정하였다 (관측치: M+3 =1853.9; 계산치 M+3 =1854.1).

실시예 2

Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-(10-(4-카르복시페녹시)데카노일))AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-(10-(4-카르복시페녹시)데카노일))SSGAPPPS-NH₂ (서열식별번호: 12)

서열식별번호: 12의 구조는 잔기 Aib2, αMeF(2F)6, 4Pal10, αMeL13, Orn16, K17, Aib20, D-Glu24, αMeY25, K31 및 Ser39를 제외하고, 표준 단일 문자 아미노산 코드를 사용하여 하기에 도시되며, 여기서 이들 아미노산 잔기의 구조는 확장되었다:

최종 커플링 단계에 4-(9-카르복시-노닐옥시)벤조산 tert-부틸 에스테르 (욱시 앱텍, 중국 상하이)를 사용한 것을 제외하고, 실질적으로 실시예 1의 절차에 기재된 바와 같이 서열식별번호: 12에 따른 화합물을 제조하였다. 분자량을 LC-MS에 의해 결정하였다 (관측치: M+3 =1887.1; 계산치 M+3 =1887.4).

실시예 3

Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-(4-(4-아이오도페닐)부타노일))AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-(4-(4-아이오도페닐)부타노일))SSGAPPPS-NH₂ (서열식별번호: 13)

서열식별번호: 13의 구조는 잔기 Aib2, αMeF(2F)6, 4Pal10, αMeL13, Orn16, K17, Aib20, D-Glu24, αMeY25, K31 및 Ser39를 제외하고, 표준 단일 문자 아미노산 코드를 사용하여 하기에 도시되며, 여기서 이들 아미노산 잔기의 구조는 확장되었다:

최종 커플링 단계에 4-(4-아이오도페닐)부티르산 (욱시 앱텍, 중국 상하이)를 사용한 것을 제외하고, 실질적으로 실시예 1의 절차에 기재된 바와 같이 서열식별번호: 13에 따른 화합물을 제조하였다. 분자량을 LC-MS에 의해 결정하였다 (관측치: M+3 =1875.1; 계산치 M+3 =1875.2).

실시예 4

Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-(4-(4-tert-부틸페닐)부타노일))AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-(4-(4-tert-부틸페닐)부타노일))SSGAPPPS-NH₂ (서열식별번호: 14)

서열식별번호: 14의 구조는 잔기 Aib2, αMeF(2F)6, 4Pal10, αMeL13, Orn16, K17, Aib20, D-Glu24, αMeY25, K31 및 Ser39를 제외하고, 표준 단일 문자 아미노산 코드를 사용하여 하기에 도시되며, 여기서 이들 아미노산 잔기의 구조는 확장되었다:

최종 커플링 단계에 4-(4-tert-부틸페닐)부티르산 (욱시 앱텍, 중국 상하이)를 사용한 것을 제외하고, 실질적으로 실시예 1의 절차에 기재된 바와 같이 서열식별번호: 14에 따른 화합물을 제조하였다. 분자량을 LC-MS에 의해 결정하였다 (관측치: M+3 =1828.3; 계산치 M+3 =1828.7).

실시예 5

Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-CO-(CH₂)₁₀-CH₃)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-CO-(CH₂)₁₀-CH₃)SSGAPPPS-NH₂ (서열식별번호: 15).

서열식별번호: 15의 구조는 잔기 Aib2, αMeF(2F)6, 4Pal10, αMeL13, Orn16, K17, Aib20, D-Glu24, αMeY25, K31 및 Ser39를 제외하고, 표준 단일 문자 아미노산 코드를 사용하여 하기에 도시되며, 여기서 이들 아미노산 잔기의 구조는 확장되었다:

최종 커플링 단계에 라우르산 (시그마 알드리치(Sigma Aldrich))을 사용한 것을 제외하고, 실질적으로 실시예 1의 절차에 기재된 바와 같이 서열식별번호: 15에 따른 화합물을 제조하였다. 분자량을 LC-MS에 의해 결정하였다 (관측치: M+3 =1815.1; 계산치 M+3 =1815.4).

실시예 6 내지 실시예 211

실시예 6 (서열식별번호: 16) 내지 실시예 494 (서열식별번호: 504)에 따른 화합물을 실질적으로 실시예 1의 절차에 기재된 바와 같이 제조하였다.

결합 검정

글루카곤 (Gcg로 지칭됨)은 일라이 릴리 앤드 캄파니(Eli Lilly and Company)에서 제조된 참조 표준물이다. GLP-1, 7-36-NH₂ (GLP-1로 지칭됨)는 씨피씨 사이언티픽(CPC Scientific) (캘리포니아주 서니베일, 97.2% 순도, 100% DMSO 중 100 μM 분취물)으로부터 입수하였다. GIP 1-42 (GIP로 지칭됨)는 상기 기재된 바와 같은 펩티드 합성 및 HPLC 크로마토그래피를 사용하여 릴리 리서치 래보러토리즈(Lilly Research Laboratories)에서 제조하였다 (>80% 순도, 100% DMSO 중 100 μM 분취물). [¹²⁵I]-방사성표지된 Gcg, GLP-1, 또는 GIP를 퍼킨 엘머(Perkin Elmer) (매사추세츠주 보스톤)로부터 입수한 [¹²⁵I]-락토퍼옥시다제를 사용하여 제조하였다.

수용체 cDNA를 pcDNA3 발현 플라스미드 내로 서브클로닝함으로써 안정하게 형질감염된 세포주를 제조하였고, 인간 배아 신장 (HEK) 293 (hGcgR 및 hGLP-1R) 또는 차이니즈 햄스터 난소 (CHO) (hGIPR) 세포 내로 형질감염시킨 후, 제네티신 (hGLP-1R 및 hGIPR) 또는 히그로마이신 B (hGcgR)를 사용하여 선택하였다.

조 세포막의 제조를 위해 2가지 방법을 사용하였다.

방법 1: 동결된 세포 펠릿을 얼음 상에서 50 mM 트리스 HCl, pH 7.5, 및 로슈 컴플리트(Roche Complete)™ EDTA 함유 프로테아제 억제제를 함유하는 저장성 완충제 중에서 용해시켰다. 세포 현탁액을 테플론(Teflon)® 막자가 장착된 유리 포터-엘베헴 균질화기를 사용하여 25 스트로크 동안 교란시켰다. 균질물을 4℃에서 1100 x g에서 10분 동안 원심분리하였다. 상청액을 수집하고 얼음 상에 저장하는 한편, 펠릿은 균질화 완충제 중에 재현탁시키고 상기 기재된 바와 같이 재균질화시켰다. 균질물을 1100 x g에서 10분 동안 원심분리하였다. 제2 상청액을 제1 상청액과 합하고, 35000 x g에서 1시간 동안 4℃에서 원심분리하였다. 생성된 막 펠릿을 대략 1 내지 3 mg/mL로 프로테아제 억제제를 함유하는 균질화 완충제 중에 재현탁시키고, 액체 질소 중에서 급속 동결시키고, 사용 시까지 -80℃ 동결기 내에 분취물로서 저장하였다.

방법 2: 동결된 세포 펠릿을 얼음 상에서 50 mM 트리스 HCl, pH 7.5, 1 mM MgCl₂, 로슈 컴플리트™ EDTA-무함유 프로테아제 억제제 및 25 유닛/ml DNAse I (인비트로젠(Invitrogen))을 함유하는 저장성 완충제 중에서 용해시켰다. 세포 현탁액을 테플론® 막자가 장착된 유리 포터-엘베헴 균질화기를 사용하여 20 내지 25 스트로크 동안 교란시켰다. 균질물을 4℃에서 1800 x g에서 15분 동안 원심분리하였다. 상청액을 수집하고 얼음 상에 저장하는 한편, 펠릿은 균질화 완충제 (DNAse I 없음) 중에 재현탁시키고 상기 기재된 바와 같이 재균질화시켰다. 균질물을 1800 x g에서 15분 동안 원심분리하였다. 제2 상청액을 제1 상청액과 합하고, 추가의 시간 동안 1800 x g에서 15분 동안 원심분리하였다. 이어서, 전체 상청액을 25000 x g에서 30분 동안 4℃에서 원심분리하였다. 생성된 막 펠릿을 대략 1 내지 3 mg/mL로 프로테아제 억제제를 함유하는 균질화 완충제 (DNAse I 없음) 중에 재현탁시키고, 사용 시까지 -80℃ 동결기 내에 분취물로서 저장하였다.

결합 결정 방법

다양한 수용체/방사성리간드 상호작용에 대한 평형 결합 해리 상수 (K_d)는 [¹²⁵I] 스톡 물질에서의 높은 프로판올 함량으로 인해 포화 결합 대신 상동 경쟁 결합 분석으로부터 결정하였다. 수용체 제제에 대해 결정된 K_d 값은 하기와 같았다: hGcgR (3.9 nM), hGLP-1R (1.2 nM) 및 hGIPR (0.14 nM).

[¹²⁵I]-글루카곤 결합

밀 배아 응집소 (WGA) 비드 (퍼킨 엘머)를 사용하는 섬광 근접 검정 (SPA) 포맷을 사용하여 인간 Gcg 수용체 결합 검정을 수행하였다. 결합 완충제는 25 mM 4-(2-히드록시에틸)-1-피페라진에탄술폰산 (HEPES), pH 7.4, 2.5 mM CaCl₂, 1 mM MgCl₂, 0.1% (w/v) 바시트라신 (리서치 프로덕츠(Research Products)), 0.003% (w/v) 폴리옥시에틸렌소르비탄 모노라우레이트 (트윈(TWEEN)®-20), 및 로슈 컴플리트™ EDTA 무함유 프로테아제 억제제를 함유하였다. 펩티드 및 Gcg를 해동시키고, 100% DMSO 중에 3-배 연속 희석하였다 (10 포인트 농도 반응 곡선). 이어서, 5 μL 연속 희석된 화합물 또는 DMSO를 45 μL 검정 결합 완충제 또는 비표지된 Gcg 대조군 (비-특이적 결합 또는 NSB, 1 μM 최종)을 함유하는 코닝(Corning)® 3632 투명 바닥 검정 플레이트로 옮겼다. 이어서, 50 μL [¹²⁵I]-Gcg (0.15 nM 최종), 50 μL 인간 GcgR 막 (1.5 μg/웰) 및 50 μL의 WGA SPA 비드 (80 내지 150 μg/웰)를 바이오텍 멀티플로 분배기로 첨가하였다. 플레이트를 밀봉하고, 플레이트 진탕기 (설정 6) 상에서 1분 동안 혼합하고, 실온에서 12시간의 인큐베이션/침강 시간 후에 퍼킨엘머 트리룩스 마이크로베타(Trilux MicroBeta)® 섬광 계수기를 사용하여 판독하였다. 반응 곡선에서 시험된 펩티드에 대한 최종 검정 농도 범위는 전형적으로 1150 nM 내지 0.058 nM이었고, 대조군 Gcg에 대해서는 1000 nM 내지 0.05 nM이었다.

[¹²⁵I]-GLP-1 결합

WGA 비드를 사용하는 SPA 포맷을 사용하여 인간 GLP-1 수용체 결합 검정을 수행하였다. 결합 완충제는 25 mM HEPES, pH 7.4, 2.5 mM CaCl₂, 1 mM MgCl₂, 0.1% (w/v) 바시트라신, 0.003% (w/v) 트윈®-20, 및 로슈 컴플리트™ EDTA 무함유 프로테아제 억제제를 함유하였다. 펩티드 및 GLP-1을 해동시키고, 100% DMSO 중에 3-배 연속 희석하였다 (10 포인트 농도 반응 곡선). 이어서, 5 μL 연속 희석된 화합물 또는 DMSO를 45 μL 검정 결합 완충제 또는 비표지된 GLP-1 대조군 (비-특이적 결합 또는 NSB, 0.25 μM 최종)을 함유하는 코닝® 3632 투명 바닥 검정 플레이트로 옮겼다. 이어서, 50 μL [¹²⁵I]-GLP-1 (0.15 nM 최종), 50 μL 인간 GLP-1R 막 (0.5 μg/웰) 및 50 μL의 WGA SPA 비드 (100 내지 150 μg/웰)를 바이오텍 멀티플로 분배기로 첨가하였다. 플레이트를 밀봉하고, 플레이트 진탕기 (설정 6) 상에서 1분 동안 혼합하고, 실온에서 5 내지 12시간의 인큐베이션/침강 시간 후에 퍼킨엘머 트리룩스 마이크로베타® 섬광 계수기를 사용하여 판독하였다. 반응 곡선에서 시험된 펩티드에 대한 최종 검정 농도 범위는 전형적으로 1150 nM 내지 0.058 nM이었고, 대조군 GLP-1에 대해서는 250 nM 내지 0.013 nM이었다.

[125I]-GIP 결합

WGA 비드를 사용하는 SPA 포맷을 사용하여 인간 GIP 수용체 결합 검정을 수행하였다. 결합 완충제는 25 mM HEPES, pH 7.4, 2.5 mM CaCl₂, 1 mM MgCl₂, 0.1% (w/v) 바시트라신, 0.003% (w/v) 트윈®-20, 및 로슈 컴플리트™ EDTA 무함유 프로테아제 억제제를 함유하였다. 펩티드 및 GIP를 해동시키고, 100% DMSO 중에 3배 연속 희석하였다 (10 포인트 농도 반응 곡선). 이어서, 5 μL 연속 희석된 화합물 또는 DMSO를 45 μL 검정 결합 완충제 또는 비표지된 GIP 대조군 (비-특이적 결합 또는 NSB, 0.25 μM 최종)을 함유하는 코닝® 3632 투명 바닥 검정 플레이트로 옮겼다. 이어서, 50 μL [¹²⁵I]-GIP (0.075-0.15 nM 최종), 50 μL 인간 GIPR 막 (3 μg/웰) 및 50 μL의 WGA SPA 비드 (100 내지 150 μg/웰)를 바이오텍 멀티플로 분배기로 첨가하였다. 플레이트를 밀봉하고, 플레이트 진탕기 (설정 6) 상에서 1분 동안 혼합하고, 실온에서 2.5 내지 12시간의 인큐베이션/침강 시간 후에 퍼킨엘머 트리룩스 마이크로베타® 섬광 계수기를 사용하여 판독하였다. 반응 곡선에서 시험된 펩티드에 대한 최종 검정 농도 범위는 전형적으로 1150 내지 0.058 nM 또는 115 nM 내지 0.0058 nM이었고, 대조군 GIP에 대해서는 250 nM 내지 0.013 nM이었다.

결합 검정 데이터 분석

펩티드, Gcg, GLP-1, 또는 GIP의 농도 곡선에 대한 미가공 CPM 데이터를, 개별 CPM 값으로부터 비특이적 결합 (각각 과량의 비표지된 Gcg, GLP-1, 또는 GIP의 존재 하에서의 결합)을 차감하고, 또한 비특이적 결합을 차감함으로써 보정된 총 결합 신호로 나누어, 퍼센트 억제로 전환시켰다. 4-파라미터 (곡선 최대, 곡선 최소, IC₅₀, 힐 기울기) 비선형 회귀 루틴 (진데이터 스크리너(Genedata Screener), 버전 12.0.4, 진데이터 아게(Genedata AG), 스위스 바젤)을 사용하여 데이터를 분석하였다. 친화도 상수 (K_i)를 절대 IC₅₀ 값으로부터 방정식 K_i = IC₅₀/(1 + D/K_d)에 기초하여 계산하였고, 여기서 D는 실험에 사용된 방사성리간드의 농도이고, IC₅₀은 결합의 50% 억제를 유발하는 농도이고, K_d는 방사성리간드의 평형 결합 해리 상수이다 (상기 기재됨). K_i에 대한 값은 기하 평균으로서 보고하였고, 오차는 평균의 표준 오차 (SEM)로서 표현되며, n은 독립적 반복 횟수와 동일하다 (상이한 날에 수행된 검정에서 결정됨). 기하 평균은 하기와 같이 계산하였다:

기하 평균 = 10^{(로그 Ki 값의 산술 평균)}

각각의 수용체 및 각각의 종에서 Ki 비 (천연 대조군 펩티드에 대한 Ki/시험 화합물에 대한 Ki)를 계산하였다. Ki 비는 천연 대조군 펩티드와 비교하여 펩티드의 겉보기 친화도의 신속한 지표이다. Ki 비 < 1은 시험 펩티드가 천연 펩티드보다 수용체에 대해 더 낮은 친화도 (더 높은 Ki 값)를 갖는다는 것을 나타내는 반면, Ki 비 > 1은 시험 펩티드가 천연 펩티드보다 수용체에 대해 더 높은 친화도 (더 낮은 Ki 값)를 갖는다는 것을 나타낸다.

n=1/x는 총 반복 횟수 (x) 중 오직 1개의 값만이 평균을 표현하는데 사용되었음을 의미한다. SEM은 n=2 이상의 비-적격 결과가 존재하는 경우에만 계산된다. 평균은 괄호 안에 나타낸 평균의 표준 오차 (SEM) 및 반복 횟수 (n)와 함께 기하 평균으로 표현된다.

표 1. 인간 GLP-1R, GcgR 및 GIPR에 대한 표시된 실시예 및 비교 분자의 시험관내 결합 친화도 (K_i).

결합 친화도

기능적 활성

기능적 hGIP-R, hGLP-1R 및 hGCGR 검정

방법: hGIPR, hGLP-1R 또는 hGCGR을 발현하는 HEK-293 클론 세포주에서의 cAMP 형성을 사용하여 기능적 활성을 결정하였다. hGIPR, hGLP-1R 또는 hGCGR 수용체-발현 세포를 20 μL 검정 부피의 1X 글루타맥스(GlutaMAX)™ (깁코(Gibco) Cat# 35050), 0.1% 소 카세인 (시그마 C4765-10ML), 250 μM IBMX (3-이소부틸-1-메틸크산틴, 아크로스(Acros) Cat# 228420010) 및 20 mM HEPES (깁코 Cat# 15630)가 보충된 DMEM (깁코 Cat# 31053) 중 대조군 폴리펩티드 또는 실시예 1 내지 3 중 하나 (DMSO 중 20 포인트 농도-반응 곡선, 2.75-배 랩사이트 에코 직접 희석, 384 웰 플레이트 코닝 Cat# 3570)로 처리하였다 (최종 DMSO 농도는 0.5%임). 또한, 1.0% 지방산 무함유, 글로불린 무함유 인간 혈청 알부민 (시그마 Cat# A3782)을 첨가하여 동일한 검정 조건 하에 실험을 수행하였다.

37℃에서 30-분 인큐베이션한 후, 생성된 세포내 cAMP의 증가를 시스바이오 cAMP 다이나믹 2 HTRF 검정 키트 (62AM4PEJ)를 사용하여 정량적으로 결정하였다. 간략하게, 세포 용해 완충제 (10 μL) 중 cAMP-d2 접합체에 이어서 또한 세포 용해 완충제 (10 μL) 중 항체 항-cAMP-Eu³⁺-크립테이트를 첨가함으로써 세포 내의 cAMP 수준을 검출하였다. 생성된 경쟁 검정을 실온에서 적어도 60분 동안 인큐베이션한 다음, 320 nm에서의 여기 및 665 nm 및 620 nm에서의 방출로 퍼킨엘머 엔비전(Envision)® 기기를 사용하여 검출하였다. 엔비전 단위 (665nm/620nm에서의 방출*10,000)는 존재하는 cAMP의 양에 반비례하였고, cAMP 표준 곡선을 사용하여 웰당 nM cAMP로 전환시켰다. 각각의 웰에서 생성된 cAMP의 양 (nM)을 인간 GIP(1-42)NH₂, hGLP-1(7-36)NH₂ 또는 hGCG에 의해 관찰된 최대 반응의 퍼센트로 전환시켰다. 4-파라미터 로지스틱 방정식에 피팅된, 퍼센트 최대 반응 vs. 첨가된 펩티드의 농도를 사용하여 비-선형 회귀 분석에 의해 상대 EC₅₀ 값 및 퍼센트 최고 (E_max)를 유도하였다.

결과: hGIP(1-42)NH₂, hGLP-1(7-36)NH₂, hGCG 및 실시예 화합물에 대한 기능적 데이터를 하기 표 2 (0.1% 소 카세인) 및 표 3 (0.1% 소 카세인, 1.0% 인간 혈청 알부민)에 제공한다.

표 2: 37℃에서 인큐베이션된 펩티드에 대한 기능적 cAMP 효력 (EC₅₀) 및 효능 (E_max) (0.1% 소 카세인의 존재 하)

ND = 결정되지 않음

^a 발현 밀도는 hGLP-1R에서의 [¹²⁵I]GLP-1(7-36)NH₂ (112 fmol/mg 단백질), hGCGR에서의 [¹²⁵I]GCG (98 fmol/mg 단백질) 및 hGIPR에서의 [¹²⁵I]GIP(1-42) (124 fmol/mg 단백질)의 상동 경쟁 결합을 사용하여 결정됨.

^b EC₅₀, nM = 기하 평균, 이어서 괄호 안의 평균의 표준 오차 및 관찰 횟수.

^c E_max, % = hGLP-1R에서의 GLP-1(7-36)NH₂, hGCGR에서의 GCG 또는 hGIPR에서의 GIP(1-42)NH₂에 대한 최대 반응의 퍼센트에 대한 산술 평균 ± 평균의 표준 오차.

제시된 모든 값은 세(3)자리 유효 숫자까지이다.

표 3: 37℃에서 인큐베이션된 펩티드에 대한 기능적 cAMP 효력 (EC₅₀) 및 효능 (E_max) (0.1% 소 카세인 및 1.0% 인간 혈청 알부민의 존재 하).

ND = 결정되지 않음

제시된 모든 값은 세(3)자리 유효 숫자까지이다.

생체내 연구

수컷 CD-1 마우스에서의 약동학

수컷 CD-1 마우스에게 200 nMol/kg을 단일 피하 투여한 후 시험 펩티드의 약동학을 평가하였다. 혈액 샘플을 168시간에 걸쳐 수집하고, 생성된 개별 혈장 농도를 사용하여 약동학적 파라미터를 계산하였다. 시험 펩티드의 무손상 질량을 측정하는 검증된 LC/MS 방법을 사용하여 혈장 (K₃ EDTA) 농도를 결정하였다. 항-GIP/GLP1 항체를 사용하는 면역친화도 기반 침전을 사용하여 100% 마우스 혈장으로부터 각각의 시험 펩티드 및 내부 표준으로서 유사체를 추출하였다. LC/MS 검출을 위해 기기를 합하였다. 평균 약동학적 파라미터는 시험 펩티드가 연장된 약동학적 프로파일과 일치하는지 결정하였다.

수컷 위스타 래트에서의 인슐린 분비

대퇴 동맥 및 대퇴 정맥 캐뉼라 (엔비고(Envigo), 인디애나주 인디애나폴리스)를 갖는 수컷 위스타 래트 (280-320 그램)를 필터 상단을 갖는 폴리카르보네이트 케이지에 단일-수용하였다. 래트를 21℃에서 12:12시간 명-암 주기 (6:00 A.M.에 점등)로 유지시키고, 먹이 및 탈이온수를 자유롭게 제공하였다. 래트를 체중별로 무작위화하고, 글루코스 투여 16시간 전에 0.04, 0.1, 0.3, 1, 3, 및 10 nmol/kg의 시험 펩티드 용량으로 1.5 ml/kg s.c. 투여한 다음, 금식시켰다. 동물을 칭량하고, i.p. 투여되는 소듐 펜토바르비탈 (65 mg/kg, 30 mg/ml)로 마취시켰다. 시간 0 혈액 샘플을 EDTA 튜브에 수집한 후, 글루코스를 i.v. 투여하였다 (0.5 mg/kg, 5 ml/kg). 글루코스의 정맥내 투여 후 시간 2, 4, 6, 10, 20 및 30분에 글루코스 및 인슐린 수준을 위해 혈액 샘플을 수집하였다. 혈장 글루코스 수준을 임상 화학 분석기를 사용하여 결정하였다. 혈장 인슐린을 전기화학발광 검정 (메소 스케일(Meso Scale), 메릴랜드주 게이더스버그)을 사용하여 결정하였다. 글루코스 및 인슐린 AUC를 군당 n = 5마리의 동물로 비히클 대조군과 비교하여 검사하였다. 결과를 제시한다 (SEM)(N). 결과는 정맥내 글루코스 내성 검사 동안 인슐린 분비에 대한 시험 펩티드 효과를 보여준다. 결과는 인슐린 분비에 대한 시험 펩티드 용량 의존성 효과를 보여준다.

식이-유발 비만 C57/B16 마우스

41-50 g으로 칭량된 C57/Bl6 식이-유발 비만 (DIO) 수컷 마우스 (타코닉(Taconic), 뉴욕주 저먼타운)를 사용하였다. 동물을 12시간 명/암 광주기 (10:00 AM에 소등 및 10:00 PM에 점등)를 갖는 온도-제어 (24℃) 시설에서 사료 및 물에 자유롭게 접근하도록 하면서 개별적으로 수용하였다. 시설에의 2주 순응 후에, 마우스를 체중에 기초하여 처리군 (n=6/군)으로 무작위화하여 각각의 군이 유사한 출발 평균 체중을 갖도록 하였다.

마우스를 비히클 (40 mM 트리스-HCl, pH 8.0) 또는 시험 펩티드로 약 0.03 nmol/kg 내지 약 10 nmol/kg의 용량 범위로 처리하였다. 14일 동안 매일 (QD) 암주기의 개시 30-90분 전에 자유롭게 급식한 DIO 마우스에게 피하로 처리를 투여하였다. 체중 및 음식물 섭취를 매일 모니터링하였다.

데이터는 군당 5-6마리의 래트의 평균 ± SEM으로 표현된다. 처리군을 비히클군과 또는 서로 비교하기 위해 일원 ANOVA에 이어서 던넷 다중 비교 검정에 의해 통계적 분석을 평가하였다. 유의차는 p<0.05에서 확인된다.

"0" 용량 군은 각각의 연구 동안의 비히클-처리된 마우스를 나타낸다. 모든 데이터는 군당 5-6마리 마우스의 평균 ± SEM으로 표현된다. "비히클로부터의 Δ"는 시험군과 비히클군 사이의 제15일의 체중 사이의 차이를 지칭한다. "% 변화"는 시험군에서 제1일 내지 제15일의 체중에서의 퍼센트 감소를 지칭한다. 비히클을 제공받은 동물에 대해 체중에서의 퍼센트 감소를 기록하였다. 비히클로부터의 Δ 및 % 변화 데이터는 검정에서 양성으로 시험된 펩티드의 경우 대조군과 통계적으로 유의하게 상이하였다 (p<0.05).

SEQUENCE LISTING <110> Eli Lilly and Company <120> GIP/GLP1 Co-Agonist Compounds <130> X22152 <150> US 62/964932 <151> 2020-01-23 <160> 511 <170> PatentIn version 3.5 <210> 1 <211> 42 <212> PRT <213> Homo sapiens <220> <221> MOD_RES <222> (42)..(42) <223> Ser at position 42 is amidated <400> 1 Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 1 5 10 15 Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 20 25 30 Lys Asn Asp Trp Lys His Asn Ile Thr Gln 35 40 <210> 2 <211> 29 <212> PRT <213> Homo sapiens <400> 2 His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 1 5 10 15 Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 20 25 <210> 3 <211> 30 <212> PRT <213> Homo sapiens <220> <221> MOD_RES <222> (30)..(30) <223> Ser at position 30 is amidated <400> 3 His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 1 5 10 15 Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg 20 25 30 <210> 4 <211> 30 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct; a compound of Formula II <220> <221> MISC_FEATURE <222> (1)..(1) <223> Xaa at position in is Y or R1-Y, wherein R1 is an Ac modification of the N-terminal amino group <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-F or alpha-methyl-F(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is K, 4Pal, Y, alpha-methyl-F, alpha-methyl-F(2F), alpha-methyl-L, alpha-methyl-V, Ac4c, Ac5c, Ac6c, Bip, 1Nal, 2Nal, OMeY, hTyr, Nle, V, 4CPhe, ChG, ChA, Bzt, 2FA, 4TAA, 2TA, 3TA, or KZ1 <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Ac5c, S, alpha-methyl-S, Aib, G, Dap, or Tle <220> <221> MISC_FEATURE <222> (12)..(12) <223> Xaa at position 12 is I or KZ1 <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-MeL or alpha-methyl-F <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (17)..(17) <223> Xaa at position 17 is Q, I, or KZ1 <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib, Orn, 4Pal, alpha-methyl-F, Ac5c, or Ac6c <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is E, KZ1, G, Orn, or 4Pal <220> <221> MISC_FEATURE <222> (22)..(22) <223> Xaa at position 22 is F, 2ClPhe, 3ClPhe, 2FPhe, 3FPhe, 3,5FPhe, 1Nal, 2Nal, alpha-methyl-F(2F), ChA, Bzt, or alpha-methyl-F <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu, E, G, or KZ1 <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is Y, alpha-methyl-Y, alpha-methyl-F, or KZ1 <220> <221> MISC_FEATURE <222> (28)..(28) <223> Xaa at position 28 is E, Orn, or KZ1 <220> <221> MISC_FEATURE <222> (30)..(30) <223> Xaa at position 30 is G, Orn, KZ1, or GR2, and a modification of the c-terminal group wherein the modification is NH2 <220> <221> MISC_FEATURE <222> (30)..(30) <223> When Xaa at position 30 is GR2, then R2 is SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9, or SEQ ID NO:10 <220> <221> MISC_FEATURE <222> (30)..(30) <223> When Xaa at position 30 is KZ1, Z1 is R5 or R4R5, wherein R4 is a linker and R5 is a fatty acid <400> 4 Xaa Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Xaa Xaa Leu Asp Xaa 1 5 10 15 Xaa Ala Gln Xaa Xaa Xaa Ile Xaa Xaa Leu Ile Xaa Gly Xaa 20 25 30 <210> 5 <211> 4 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (1)..(1) <223> Xaa at position 1 is P or KZ1 <400> 5 Xaa Ser Ser Gly 1 <210> 6 <211> 4 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (1)..(1) <223> Xaa at position 1 is P or KZ1 <220> <221> MOD_RES <222> (4)..(4) <223> Xaa at position 4 is modified with R3, where R3 is is a modification of the C-terminal group, wherein the modification is NH2 <400> 6 Xaa Ser Ser Gly 1 <210> 7 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (1)..(1) <223> Xaa at position 1 is P or KZ1 <220> <221> MISC_FEATURE <222> (5)..(5) <223> Xaa at position 5 is A or Orn <220> <221> MISC_FEATURE <222> (9)..(9) <223> Xaa at position 9 is S or Orn <400> 7 Xaa Ser Ser Gly Xaa Pro Pro Pro Xaa 1 5 <210> 8 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (1)..(1) <223> Xaa at position 1 is P or KZ1 <220> <221> MISC_FEATURE <222> (5)..(5) <223> Xaa at position 5 is A or Orn <220> <221> MISC_FEATURE <222> (9)..(9) <223> Xaa at position 9 is S or Orn <220> <221> MOD_RES <222> (9)..(9) <223> Xaa at position 9 is modified with R3, where R3 is is a modification of the C-terminal group, wherein the modification is NH2 <400> 8 Xaa Ser Ser Gly Xaa Pro Pro Pro Xaa 1 5 <210> 9 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (1)..(1) <223> Xaa at position 1 is P or KZ1 <220> <221> MISC_FEATURE <222> (5)..(5) <223> Xaa at position 5 is A or Orn <220> <221> MISC_FEATURE <222> (9)..(9) <223> Xaa at position 9 is S or Orn <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is KZ1 <400> 9 Xaa Ser Ser Gly Xaa Pro Pro Pro Xaa Xaa 1 5 10 <210> 10 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (1)..(1) <223> Xaa at position 1 is P or KZ1 <220> <221> MISC_FEATURE <222> (5)..(5) <223> Xaa at position 5 is A or Orn <220> <221> MISC_FEATURE <222> (9)..(9) <223> Xaa at position 9 is S or Orn <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is KZ1 <220> <221> MOD_RES <222> (10)..(10) <223> Xaa at position 10 is modified with R3, where R3 is is a modification of the C-terminal group, wherein the modification is NH2 <400> 10 Xaa Ser Ser Gly Xaa Pro Pro Pro Xaa Xaa 1 5 10 <210> 11 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-F(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 11 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 12 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-F(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-L <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-Amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-Amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 12 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 13 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-F(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-Amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(4-(4-iodophe nyl)butanoyl) <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-Amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(4-(4-iodophe nyl)butanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 13 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 14 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-F(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-Amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(4-(4-tert-bu tylphenyl)butanoyl) <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-Amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(4-(4-tert-bu tylphenyl)butanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 14 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 15 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-F(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-Amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-Amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 15 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 16 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 16 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 17 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)14-CH 3 <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)14-CH 3 <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 17 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 18 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CH 3 <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CH 3 <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 18 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 19 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-CO-(CH2)12-CO2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-CO-(CH2)12-CO2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 19 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 20 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2--(10-(4-carboxyphenoxy)de canoyl) <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2--(10-(4-carboxyphenoxy)de canoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 20 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 21 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-CO-(CH2)12-CO2 H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-CO-(CH2)12-CO2 H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 21 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 22 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-(10-(4-carboxy phenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-(10-(4-carboxy phenoxy)decanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 22 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 23 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-CO-(CH2)14-CH3 <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-CO-(CH2)14-CH3 <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 23 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 24 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-CO-(CH2)10-CH3 <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-CO-(CH2)10-CH3 <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 24 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 25 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 25 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 26 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 26 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 27 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(20) <223> Xaa at position 24 is D-Glu <220> <221> misc_feature <222> (24)..(24) <223> Xaa can be any naturally occurring amino acid <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 27 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 28 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (30)..(30) <223> Lys at position 30 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 28 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Lys Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 29 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is amidated <400> 29 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> 30 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 30 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 31 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)14-CH 3 <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)14-CH 3 <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 31 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 32 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)14-CH 3 <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)14-CH 3 <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 32 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 33 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)14-CH 3 <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)14-CH 3 <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 33 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 34 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)14-CH 3 <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (30)..(30) <223> Lys at position 30 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)14-CH 3 <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 34 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Lys Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 35 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)14-CH 3 <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)14-CH 3 <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is amidated <400> 35 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> 36 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)14-CH 3 <220> <221> MOD_RES <222> (30)..(30) <223> Lys at position 30 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)14-CH 3 <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 36 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 37 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MOD_RES <222> (10)..(10) <223> Lys at position 10 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 37 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Lys Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 38 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MOD_RES <222> (12)..(12) <223> Lys at position 12 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 38 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Lys Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 39 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MOD_RES <222> (10)..(10) <223> Lys at position 10 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)14-CH 3 <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)14-CH 3 <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 39 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Lys Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 40 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)3-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)3-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 40 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 41 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)3-(gamma-Glu)-CO-(CH2)14-CH 3 <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)3-(gamma-Glu)-CO-(CH2)14-CH 3 <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 41 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 42 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)14-CH 3 <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MOD_RES <222> (25)..(25) <223> Lys at position 25 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)14-CH 3 <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 42 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Lys Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 43 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(epsilon-Lys-)-CO-(CH2)12 -CO2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(epsilon-Lys-)-CO-(CH2)12 -CO2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 43 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 44 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(epsilon-Lys)-(gamma-Glu) -CO-(CH2)12-CO2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(25) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(epsilon-Lys)-(gamma-Glu) -CO-(CH2)12-CO2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 44 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 45 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(epsilon-Lys)-(gamma-Glu)- CO-(CH2)12-CO2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(epsilon-Lys)-(gamma-Glu)- CO-(CH2)12-CO2H <400> 45 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 46 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (epsilon-Lys)-(2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)- CO-(CH2)12-CO2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (epsilon-Lys)-(2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)- CO-(CH2)12-CO2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 46 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 47 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (epsilon-Lys)-(2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu) -CO-(CH2)12-CO2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (epsilon-Lys)-(2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu) -CO-(CH2)12-CO2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 47 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 48 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (epsilon-Lys)-(gamma-Glu)-CO-(CH2)12-CO2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (epsilon-Lys)-(gamma-Glu)-CO-(CH2)12-CO2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 48 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 49 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (epsilon-Lys)-(gamma-Glu)2-CO-(CH2)12-CO2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (epsilon-Lys)-(gamma-Glu)2-CO-(CH2)12-CO2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 49 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 50 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (epsilon-Lys)-(epsilon-Lys)-(gamma-Glu)-CO-(CH2)12-CO2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (epsilon-Lys)-(epsilon-Lys)-(gamma-Glu)-CO-(CH2)12-CO2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 50 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 51 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (gamma-Glu)-(2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (gamma-Glu)-(2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 51 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 52 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (gamma-Glu)-(2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-CO-(CH2)12-CO2 H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (gamma-Glu)-(2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-CO-(CH2)12-CO2 H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 52 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 53 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-(2-[2-(2-amino -ethoxy)-ethoxy]-acetyl)-CO-(CH2)12-CO2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-(2-[2-(2-amino -ethoxy)-ethoxy]-acetyl)-CO-(CH2)12-CO2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 53 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 54 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 54 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 55 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position10 is alpha-methyl-Phe <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 55 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 56 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Phe <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 56 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 57 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (22)..(22) <223> Xaa at position 22 is alpha-methyl-Phe <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 57 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Xaa Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 58 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Phe <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 58 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 59 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is alpha-methyl-Ser <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 59 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Tyr Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 60 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 60 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Tyr Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 61 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 61 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 62 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is alpha-methyl-Val <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 62 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 63 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is Ac5c <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 63 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 64 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is Ac6c <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 64 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 65 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is Bip <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 65 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 66 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 1Nal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 66 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 67 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 2Nal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 67 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 68 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is OMeY <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 68 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 69 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is hTyr <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 69 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 70 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is Nle <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 70 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 71 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (22)..(22) <223> Xaa at position 22 is 2ClPhe <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 71 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Xaa Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 72 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (22)..(22) <223> Xaa at position 22 is 3ClPhe <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 72 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Xaa Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 73 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (22)..(22) <223> Xaa at position 22 is 2FPhe <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 73 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Xaa Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 74 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (22)..(22) <223> Xaa at position 22 is 3FPhe <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 74 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Xaa Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 75 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (22)..(22) <223> Xaa at position 22 is 3,5FPhe <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 75 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Xaa Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 76 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (22)..(22) <223> Xaa at position 22 is 1Nal <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 76 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Xaa Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 77 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(4-(4-tert-bu tylphenyl)butanoyl) <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MOD_RES <222> (25)..(25) <223> Lys at position 25 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(4-(4-tert-bu tylphenyl)butanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 77 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Lys Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 78 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(4-(4-tert-bu tylphenyl)butanoyl) <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (25)..(25) <223> Lys at position 25 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(4-(4-tert-bu tylphenyl)butanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 78 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Glu Lys Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 79 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 79 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Lys Phe Ile Lys Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 80 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 80 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 81 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 81 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 82 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is amidated <400> 82 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> 83 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 83 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 84 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 84 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 85 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is amidated <400> 85 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> 86 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-CO-(CH2)12-CO2 H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-CO-(CH2)12-CO2 H <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 86 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 87 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)3-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)3-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 87 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 88 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-CO-(CH2)12-CO2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-CO-(CH2)12-CO2H <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 88 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 89 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-CO-(CH2)12-CO2 H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-CO-(CH2)12-CO2 H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 89 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 90 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)3-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)3-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 90 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 91 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-CO-(CH2)12-CO2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-CO-(CH2)12-CO2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 91 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 92 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (22)..(22) <223> Xaa at position 22 is alpha-methyl-Phe <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 92 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Xaa Ile Lys Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 93 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Phe <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 93 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 94 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (22)..(22) <223> Xaa at position 22 is alpha-methyl-Phe <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Phe <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 94 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Xaa Ile Lys Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 95 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (22)..(22) <223> Xaa at position 22 is alpha-methyl-Phe <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 95 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Xaa Ile Lys Tyr Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 96 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 96 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Gln Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 97 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 97 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 98 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (22)..(22) <223> Xaa at position 22 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 98 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Xaa Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 99 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 99 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 100 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 100 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Val Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 101 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 101 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Val Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 102 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (22)..(22) <223> Xaa at position 22 is alpha-methyl-Phe <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 102 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Val Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Xaa Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 103 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (22)..(22) <223> Xaa at position 22 is alpha-methyl-Phe <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 103 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Val Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Xaa Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 104 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is Ac5c <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (22)..(22) <223> Xaa at position 22 is alpha-methyl-Phe <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 104 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Xaa Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 105 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is Ac4c <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 105 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 106 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4CPhe <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 106 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 107 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is ChG <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 107 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 108 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is ChA <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 108 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 109 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (22)..(22) <223> Xaa at position 22 is 2Nal <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 109 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Xaa Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 110 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 110 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Gly Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 111 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 111 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Gly 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 112 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 112 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Gly Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 113 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 113 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Gly Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 114 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 114 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Gly Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 115 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MOD_RES <222> (10)..(10) <223> Lys at position 10 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 115 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Lys Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 116 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MOD_RES <222> (10)..(10) <223> Lys at position 10 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 116 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Lys Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 117 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MOD_RES <222> (10)..(10) <223> Lys at position 10 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 117 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Lys Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 118 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MOD_RES <222> (10)..(10) <223> Lys at position 10 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 118 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Lys Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 119 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MOD_RES <222> (10)..(10) <223> Lys at position 10 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (22)..(22) <223> Xaa at position 22 is alpha-methyl-Phe <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 119 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Lys Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Lys Xaa Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 120 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MOD_RES <222> (10)..(10) <223> Lys at position 10 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (22)..(22) <223> Xaa at position 22 is alpha-methyl-Phe <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 120 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Lys Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Glu Xaa Ile Lys Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 121 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MOD_RES <222> (10)..(10) <223> Lys at position 10 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (22)..(22) <223> Xaa at position 22 is alpha-methyl-Phe <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 121 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Lys Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Glu Xaa Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 122 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MOD_RES <222> (10)..(10) <223> Lys at position 10 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (22)..(22) <223> Xaa at position 22 is alpha-methyl-Phe <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 122 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Lys Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Glu Xaa Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 123 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 123 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 124 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 124 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Val Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 125 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 125 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Val Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 126 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is Ac5c <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 126 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 127 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (22)..(22) <223> Xaa at position 22 is alpha-methyl-Phe <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 127 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Xaa Ile Lys Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 128 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (22)..(22) <223> Xaa at position 22 is alpha-methyl-Phe <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 128 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Val Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Xaa Ile Lys Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 129 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (22)..(22) <223> Xaa at position 22 is alpha-methyl-Phe <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 129 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Val Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Xaa Ile Lys Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 130 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is Ac5c <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (22)..(22) <223> Xaa at position 22 is alpha-methyl-Phe <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 130 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Xaa Ile Lys Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 131 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (22)..(22) <223> Xaa at position 22 is alpha-methyl-Phe <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Phe <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 131 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Xaa Ile Lys Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 132 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (22)..(22) <223> Xaa at position 22 is alpha-methyl-Phe <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Phe <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 132 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Val Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Xaa Ile Lys Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 133 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (22)..(22) <223> Xaa at position 22 is alpha-methyl-Phe <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Phe <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 133 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Val Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Xaa Ile Lys Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 134 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is Ac5c <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (22)..(22) <223> Xaa at position 22 is alpha-methyl-Phe <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Phe <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 134 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Xaa Ile Lys Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 135 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(7-(4-carboxy phenoxy)heptanoyl) <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(7-(4-carboxy phenoxy)heptanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 135 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 136 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(8-(4-carboxy phenoxy)octanoyl) <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(8-(4-carboxy phenoxy)octanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 136 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 137 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 137 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 138 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 138 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 139 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 139 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 140 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MOD_RES <222> (10)..(10) <223> Lys at position 10 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(4-(4-tert-bu tylphenyl)butanoyl) <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(4-(4-tert-bu tylphenyl)butanoyl) <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 140 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Lys Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 141 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(4-(4-tert-bu tylphenyl)butanoyl) <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(4-(4-tert-bu tylphenyl)butanoyl) <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 141 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 142 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(4-(4-tert-bu tylphenyl)butanoyl) <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(4-(4-tert-bu tylphenyl)butanoyl) <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 142 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 143 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(4-(4-tert-bu tylphenyl)butanoyl) <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(4-(4-tert-bu tylphenyl)butanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 143 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 144 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(4-(4-tert-bu tylphenyl)butanoyl) <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (30)..(30) <223> Lys at position 30 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(4-(4-tert-bu tylphenyl)butanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 144 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Lys Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 145 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(4-(4-tert-bu tylphenyl)butanoyl) <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(4-(4-tert-bu tylphenyl)butanoyl) <220> <221> MOD_RES <222> (40)..(40) <223> Ser at position 40 is amidated <400> 145 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> 146 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MOD_RES <222> (10)..(10) <223> Lys at position 10 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 146 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Lys Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 147 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 147 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 148 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 148 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 149 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 149 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 150 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (30)..(30) <223> Lys at position 30 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 150 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Lys Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 151 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is amidated <400> 151 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> 152 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is Bzt <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 152 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 153 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 2FA <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 153 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 154 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4TAA <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 154 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 155 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 2TA <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 155 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 156 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 3TA <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 156 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 157 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (22)..(22) <223> Xaa at position 22 is Bzt <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 157 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Xaa Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 158 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (22)..(22) <223> Xaa at position 22 is ChA <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 158 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Xaa Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 159 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Orn <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 159 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 160 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is Orn <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 160 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Xaa Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 161 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MISC_FEATURE <222> (28)..(28) <223> Xaa at position 28 is Orn <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 161 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Xaa Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 162 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MISC_FEATURE <222> (30)..(30) <223> Xaa at position 30 is Orn <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 162 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Xaa Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 163 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (35)..(35) <223> Xaa at position 35 is Orn <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 163 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Xaa Pro Pro Pro Ser 35 <210> 164 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (39)..(39) <223> Xaa at position 39 is Orn <220> <221> MOD_RES <222> (39)..(39) <223> Orn at position 39 is amidated <400> 164 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Xaa 35 <210> 165 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (35)..(35) <223> Xaa at position 35 is Orn <220> <221> MISC_FEATURE <222> (39)..(39) <223> Xaa at position 39 is Orn <220> <221> MOD_RES <222> (39)..(39) <223> Orn at position 39 is amidated <400> 165 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Xaa Pro Pro Pro Xaa 35 <210> 166 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is 4Pal <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 166 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 167 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is 4Pal <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 167 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Xaa Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 168 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 168 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Glu Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 169 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Phe <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 169 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Glu Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 170 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(epsilon-Lys)-CO-(CH2)12- CO2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(epsilon-Lys)-CO-(CH2)12- CO2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 170 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 171 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (epsilon-Lys)-(gamma-Glu)-CO-(CH2)12-CO2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (epsilon-Lys)-(gamma-Glu)-CO-(CH2)12-CO2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 171 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 172 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (epsilon-Lys)-(epsilon-Lys)-(gamma-Glu)-CO-(CH2)12-CO2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (epsilon-Lys)-(epsilon-Lys)-(gamma-Glu)-CO-(CH2)12-CO2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 172 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 173 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(epsilon-Lys)-CO-(CH2)12- CO2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(epsilon-Lys)-CO-(CH2)12- CO2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 173 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Val Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 174 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (epsilon-Lys)-(gamma-Glu)-CO-(CH2)12-CO2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (epsilon-Lys)-(gamma-Glu)-CO-(CH2)12-CO2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 174 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Val Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 175 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (epsilon-Lys)-(epsilon-Lys)-(gamma-Glu)-CO-(CH2)12-CO2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (epsilon-Lys)-(epsilon-Lys)-(gamma-Glu)-CO-(CH2)12-CO2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 175 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Val Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 176 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(epsilon-Lys)-CO-(CH2)12- CO2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(epsilon-Lys)-CO-(CH2)12- CO2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 176 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Val Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 177 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (epsilon-Lys)-(gamma-Glu)-CO-(CH2)12-CO2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (epsilon-Lys)-(gamma-Glu)-CO-(CH2)12-CO2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 177 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Val Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 178 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (epsilon-Lys)-(epsilon-Lys)-(gamma-Glu)-CO-(CH2)12-CO2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (epsilon-Lys)-(epsilon-Lys)-(gamma-Glu)-CO-(CH2)12-CO2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 178 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Val Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 179 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is alpha-methyl-Phe <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 179 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 180 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Ac5c <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 180 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 181 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Ac6c <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 181 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 182 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 182 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 183 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (22)..(22) <223> Xaa at position 22 is alpha-methyl-Phe <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 183 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Xaa Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 184 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (22)..(22) <223> Xaa at position 22 is alpha-methyl-Phe <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Phe <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 184 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Xaa Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 185 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 185 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Val Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 186 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 186 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Val Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 187 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-Amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(4-(4-tert-bu tylphenyl)butanoyl) <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-Amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(4-(4-tert-bu tylphenyl)butanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 187 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Val Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 188 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(4-(4-tert-bu tylphenyl)butanoyl) <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(4-(4-tert-bu tylphenyl)butanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 188 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Val Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 189 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 189 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Val Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 190 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 190 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Val Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 191 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 191 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Val Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 192 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 192 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Val Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 193 <211> 34 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (34)..(34) <223> Gly at position 34 is amidated <400> 193 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly <210> 194 <211> 31 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is amidated <400> 194 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys 20 25 30 <210> 195 <211> 31 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(epsilon-Lys)-CO-(CH2)12- CO2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(epsilon-Lys)-CO-(CH2)12- CO2H <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is amidated <400> 195 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys 20 25 30 <210> 196 <211> 31 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (epsilon-Lys)-(gamma-Glu)-CO-(CH2)12-CO2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (epsilon-Lys)-(gamma-Glu)-CO-(CH2)12-CO2H <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is amidated <400> 196 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys 20 25 30 <210> 197 <211> 31 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (epsilon-Lys)-(epsilon-Lys)-(gamma-Glu)-CO-(CH2)12-CO2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (epsilon-Lys)-(epsilon-Lys)-(gamma-Glu)-CO-(CH2)12-CO2H <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is amidated <400> 197 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys 20 25 30 <210> 198 <211> 34 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (34)..(34) <223> Gly at position 34 is amidated <400> 198 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly <210> 199 <211> 30 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (30)..(30) <223> Gly at position 30 is amidated <400> 199 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Glu Gly Gly 20 25 30 <210> 200 <211> 30 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MISC_FEATURE <222> (30)..(30) <223> Xaa at position 30 is Orn <220> <221> MOD_RES <222> (30)..(30) <223> Orn at position 30 is amidated <400> 200 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Glu Gly Xaa 20 25 30 <210> 201 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-CO-(CH2)12-CO2H <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-CO-(CH2)12-CO2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 201 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Lys Phe Ile Lys Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 202 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-CO-(CH2)12-CO2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-CO-(CH2)12-CO2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 202 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 203 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-CO-(CH2)12-CO2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-CO-(CH2)12-CO2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 203 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 204 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-CO-(CH2)12-CO2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-CO-(CH2)12-CO2H <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is amidated <400> 204 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> 205 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-CO-(CH2)12-CO2H <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-CO-(CH2)12-CO2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 205 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 206 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-CO-(CH2)12-CO2H <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-CO-(CH2)12-CO2H <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is amidated <400> 206 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> 207 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (epsilon-Lys)-(gamma-Glu)-CO-(CH2)12-CO2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (epsilon-Lys)-(gamma-Glu)-CO-(CH2)12-CO2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 207 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 208 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (epsilon-Lys)-(epsilon-Lys)-(gamma-Glu)-CO-(CH2)12-CO2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (epsilon-Lys)-(epsilon-Lys)-(gamma-Glu)-CO-(CH2)12-CO2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 208 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 209 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Dap <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 209 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 210 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Dap <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 210 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Tyr Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 211 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Dap <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 211 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Val Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 212 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Tle <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 212 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 213 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(4-(4-tert-bu tylphenyl)butanoyl) <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(4-(4-tert-bu tylphenyl)butanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 213 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 214 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(4-(4-tert-bu tylphenyl)butanoyl) <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(4-(4-tert-bu tylphenyl)butanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 214 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 215 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(4-(4-tert-bu tylphenyl)butanoyl) <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(4-(4-tert-bu tylphenyl)butanoyl) <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is amidated <400> 215 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> 216 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(4-(4-tert-bu tylphenyl)butanoyl) <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(4-(4-tert-bu tylphenyl)butanoyl) <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is amidated <400> 216 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> 217 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(4-(4-tert-bu tylphenyl)butanoyl) <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(4-(4-tert-bu tylphenyl)butanoyl) <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 217 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 218 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-(4-(4-tert-but ylphenyl)butanoyl) <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-(4-(4-tert-but ylphenyl)butanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 218 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 219 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-(4-(4-tert-but ylphenyl)butanoyl) <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-(4-(4-tert-but ylphenyl)butanoyl) <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is amidated <400> 219 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> 220 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-CO-(CH2)12-CO2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-CO-(CH2)12-CO2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 220 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 221 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Ac5c <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 221 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 222 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is alpha-methyl-Ser <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 222 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Val Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 223 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is alpha-methyl-Ser <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (31)..(31) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 223 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Lys Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 224 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is alpha-methyl-Ser <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 224 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 225 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is alpha-methyl-Ser <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 225 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Lys Phe Ile Lys Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 226 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is alpha-methyl-Ser <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 226 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 227 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is alpha-methyl-Ser <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 227 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 228 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 228 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Lys Phe Ile Lys Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 229 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 229 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 230 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 230 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 231 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is amidated <400> 231 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> 232 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-CO-(CH2)12-CO2H <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-CO-(CH2)12-CO2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 232 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 233 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-CO-(CH2)12-CO2H <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-CO-(CH2)12-CO2H <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is amidated <400> 233 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> 234 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)3-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)3-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 234 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 235 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)3-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)3-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is amidated <400> 235 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> 236 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)3-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)3-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 236 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 237 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)3-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)3-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 237 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 238 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)3-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)3-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is amidated <400> 238 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> 239 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)3-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)3-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is amidated <400> 239 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> 240 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 240 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Tyr Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 241 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 241 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Tyr Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 242 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is amidated <400> 242 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Tyr Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> 243 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 243 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Tyr Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 244 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 244 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Tyr Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 245 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is amidated <400> 245 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Tyr Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> 246 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 246 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Tyr Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 247 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 247 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Tyr Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 248 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is amidated <400> 248 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Tyr Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> 249 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 249 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Tyr Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 250 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 250 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Tyr Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 251 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is amidated <400> 251 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Tyr Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> 252 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(11-(4-carbox yphenoxy)undecanoyl <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(11-(4-carbox yphenoxy)undecanoyl <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is amidated <400> 252 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> 253 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 253 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 254 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 254 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 255 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is amidated <400> 255 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> 256 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 256 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 257 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 257 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 258 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is amidated <400> 258 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> 259 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 2Nal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 259 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 260 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 2Nal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 260 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 261 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 2Nal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is amidated <400> 261 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> 262 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 2Nal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 262 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 263 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 2Nal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 263 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 264 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 2Nal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is amidated <400> 264 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> 265 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 2Nal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-CO-(CH2)12-CO2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-CO-(CH2)12-CO2H <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 265 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 266 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 2Nal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-CO-(CH2)12-CO2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-CO-(CH2)12-CO2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 266 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 267 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 2Nal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-CO-(CH2)12-CO2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-CO-(CH2)12-CO2H <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is amidated <400> 267 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> 268 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 2Nal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-CO-(CH2)12-CO2H <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-CO-(CH2)12-CO2H <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is amidated <400> 268 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> 269 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is OMeY <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 269 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 270 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is OMeY <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 270 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 271 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is OMeY <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is amidated <400> 271 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> 272 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is OMeY <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 272 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 273 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is OMeY <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 273 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 274 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is OMeY <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is amidated <400> 274 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> 275 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is OMeY <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-CO-(CH2)12-CO2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-CO-(CH2)12-CO2H <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 275 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 276 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is OMeY <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-CO-(CH2)12-CO2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-CO-(CH2)12-CO2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 276 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 277 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is OMeY <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-CO-(CH2)12-CO2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-CO-(CH2)12-CO2H <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is amidated <400> 277 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> 278 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is OMeY <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-CO-(CH2)12-CO2H <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-CO-(CH2)12-CO2H <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is amidated <400> 278 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> 279 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is Nle <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 279 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 280 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is hTyr <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 280 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 281 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is Nle <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-CO-(CH2)12-CO2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-CO-(CH2)12-CO2H <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 281 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 282 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is hTyr <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-CO-(CH2)12-CO2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-CO-(CH2)12-CO2H <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 282 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 283 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is amidated <400> 283 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> 284 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 284 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 285 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 285 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 286 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is amidated <400> 286 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> 287 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is OMeY <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 287 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 288 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is OMeY <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 288 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 289 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is OMeY <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 289 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 290 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is OMeY <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 290 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 291 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 2Nal <220> <221> misc_feature <222> (13)..(13) <223> Xaa can be any naturally occurring amino acid <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 291 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 292 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 2Nal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 292 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 293 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 2Nal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 293 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 294 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 2Nal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 294 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 295 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(11-(4-carbox yphenoxy)undecanoyl) <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(11-(4-carbox yphenoxy)undecanoyl) <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is amidated <400> 295 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> 296 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(11-(4-carbox yphenoxy)undecanoyl <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(11-(4-carbox yphenoxy)undecanoyl <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 296 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 297 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(11-(4-carbox yphenoxy)undecanoyl <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(11-(4-carbox yphenoxy)undecanoyl <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 297 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 298 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(11-(4-carbox yphenoxy)undecanoyl <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(11-(4-carbox yphenoxy)undecanoyl <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is amidated <400> 298 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> 299 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is OMeY <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 299 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 300 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is OMeY <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 31 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 300 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 301 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is OMeY <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is amidated <400> 301 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> 302 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MOD_RES <222> (10)..(10) <223> Lys at position 10 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 302 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Lys Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 303 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MOD_RES <222> (10)..(10) <223> Lys at position 10 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (22)..(22) <223> Xaa at position 22 is alpha-methyl-Phe <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 303 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Lys Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Xaa Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 304 <211> 30 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MOD_RES <222> (10)..(10) <223> Lys at position 10 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (30)..(30) <223> Gly at position 30 is amidated <400> 304 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Lys Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly 20 25 30 <210> 305 <211> 30 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (30)..(30) <223> Gly at position 30 is amidated <400> 305 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Glu Gly Gly 20 25 30 <210> 306 <211> 30 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MOD_RES <222> (30)..(30) <223> Gly at position 30 is amidated <400> 306 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Lys Gly Gly 20 25 30 <210> 307 <211> 30 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MOD_RES <222> (10)..(10) <223> Lys at position 10 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (22)..(22) <223> Xaa at position 22 is alpha-methyl-Phe <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (30)..(30) <223> Gly at position 30 is amidated <400> 307 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Lys Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Xaa Ile Xaa Xaa Leu Ile Glu Gly Gly 20 25 30 <210> 308 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MISC_FEATURE <222> (28)..(28) <223> Xaa at position 28 is Orn <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 308 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Xaa Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 309 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is Orn <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 309 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Xaa Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 310 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 310 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Tyr Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 311 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 311 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Tyr Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 312 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is amidated <400> 312 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Tyr Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> 313 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is alpha-methyl-Ser <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 313 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Tyr Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 314 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 314 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Val Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 315 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is alpha-methyl-Ser <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 315 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Val Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 316 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is alpha-methyl-Ser <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 316 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 317 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is alpha-methyl-Ser <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 317 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Tyr Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 318 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 318 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Val Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 319 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is alpha-methyl-Ser <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 319 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Val Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 320 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is hTyr <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 320 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 321 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(11-(4-carbox yphenoxy)undecanoyl <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(11-(4-carbox yphenoxy)undecanoyl <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 321 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 322 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(11-(4-carbox yphenoxy)undecanoyl <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(11-(4-carbox yphenoxy)undecanoyl <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 322 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Tyr Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 323 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(11-(4-carbox yphenoxy)undecanoyl <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(11-(4-carbox yphenoxy)undecanoyl <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 323 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Val Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 324 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is Nle <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 324 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 325 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is Orn <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 325 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Xaa Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 326 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is Orn <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 326 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Tyr Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Xaa Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 327 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is Orn <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 327 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Val Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Xaa Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 328 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 328 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Val Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 329 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 329 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Val Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 330 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is hTyr <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 330 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 331 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is Nle <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 331 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 332 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 332 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 333 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is hTyr <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 333 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 334 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is amidated <400> 334 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> 335 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 335 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Val Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 336 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 336 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Val Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 337 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is hTyr <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 337 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 338 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is Nle <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 338 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 339 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 339 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Val Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 340 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 340 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Val Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 341 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(11-(4-carbox yphenoxy)undecanoyl <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(11-(4-carbox yphenoxy)undecanoyl <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 341 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 342 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is hTyr <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 342 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 343 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is Nle <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 343 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 344 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 344 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 345 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is hTyr <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 345 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 346 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-CO-(CH2)12-CO2 H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-CO-(CH2)12-CO2 H <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 346 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 347 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-CO-(CH2)12-CO2 H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-CO-(CH2)12-CO2 H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 347 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 348 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-CO-(CH2)12-CO2 H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-CO-(CH2)12-CO2 H <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is amidated <400> 348 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> 349 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-CO-(CH2)12-CO2 H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-CO-(CH2)12-CO2 H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 349 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 350 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-CO-(CH2)12-CO2 H <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-CO-(CH2)12-CO2 H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 350 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 351 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-CO-(CH2)12-CO2 H <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-CO-(CH2)12-CO2 H <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is amidated <400> 351 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> 352 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)3-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)3-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 352 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 353 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)3-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)3-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 353 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Tyr Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 354 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)3-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)3-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 354 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Val Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 355 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)3-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)3-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 355 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 356 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)3-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)3-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 356 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Tyr Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 357 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)3-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)3-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 357 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Val Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 358 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is Orn <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 358 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Xaa Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 359 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is Orn <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 359 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Tyr Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Xaa Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 360 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is Orn <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 360 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Val Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Xaa Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 361 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is Orn <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 361 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Xaa Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 362 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is Orn <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 362 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Tyr Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Xaa Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 363 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is Orn <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 363 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Val Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Xaa Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 364 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is Orn <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 364 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Xaa Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 365 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is Orn <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 365 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Tyr Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Xaa Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 366 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is Orn <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 366 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Val Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Xaa Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 367 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 367 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 368 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 368 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 369 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is amidated <400> 369 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> 370 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 370 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 371 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-(10-(4-carboxy phenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-(10-(4-carboxy phenoxy)decanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 371 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 372 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-(10-(4-carboxy phenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-(10-(4-carboxy phenoxy)decanoyl) <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is amidated <400> 372 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> 373 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(2-[2-(2-amin o-ethoxy)-ethoxy]-acetyl)-CO-(CH2)12-CO2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(2-[2-(2-amin o-ethoxy)-ethoxy]-acetyl)-CO-(CH2)12-CO2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 373 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Tyr Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 374 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-(2-[2-(2-amino -ethoxy)-ethoxy]-acetyl)2-CO-(CH2)12-CO2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-(2-[2-(2-amino -ethoxy)-ethoxy]-acetyl)2-CO-(CH2)12-CO2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 374 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Tyr Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 375 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-(2-[2-(2-amino -ethoxy)-ethoxy]-acetyl)-CO-(CH2)12-CO2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-(2-[2-(2-amino -ethoxy)-ethoxy]-acetyl)-CO-(CH2)12-CO2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 375 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Tyr Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 376 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-CO-(CH2)12-CO2 H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-CO-(CH2)12-CO2 H <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 376 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Tyr Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 377 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-CO-(CH2)12-CO2 H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-CO-(CH2)12-CO2 H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 377 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Tyr Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 378 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-CO-(CH2)12-CO2 H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-CO-(CH2)12-CO2 H <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is amidated <400> 378 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Tyr Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> 379 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-CO-(CH2)12-CO2 H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-CO-(CH2)12-CO2 H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 379 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Tyr Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 380 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-CO-(CH2)12-CO2 H <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-CO-(CH2)12-CO2 H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 380 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Tyr Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 381 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-CO-(CH2)12-CO2 H <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-CO-(CH2)12-CO2 H <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is amidated <400> 381 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Tyr Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> 382 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-(10-(4-carboxy phenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-(10-(4-carboxy phenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 382 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Tyr Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 383 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-(10-(4-carboxy phenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-(10-(4-carboxy phenoxy)decanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 383 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Tyr Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 384 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-(10-(4-carboxy phenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-(10-(4-carboxy phenoxy)decanoyl) <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is amidated <400> 384 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Tyr Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> 385 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-(10-(4-carboxy phenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-(10-(4-carboxy phenoxy)decanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 385 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Tyr Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 386 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-(10-(4-carboxy phenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-(10-(4-carboxy phenoxy)decanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 386 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Tyr Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 387 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-(10-(4-carboxy phenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-(10-(4-carboxy phenoxy)decanoyl) <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is amidated <400> 387 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Tyr Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> 388 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-(10-(4-carboxy phenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-(10-(4-carboxy phenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 388 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Val Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 389 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-(10-(4-carboxy phenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-(10-(4-carboxy phenoxy)decanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 389 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Val Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 390 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is amidated <400> 390 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Val Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> 391 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-(10-(4-carboxy phenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-(10-(4-carboxy phenoxy)decanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 391 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Val Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 392 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-(10-(4-carboxy phenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-(10-(4-carboxy phenoxy)decanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 392 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Val Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 393 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is amidated <400> 393 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Val Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> 394 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-CO-(CH2)12-CO2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-CO-(CH2)12-CO2H <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 394 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 395 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-CO-(CH2)12-CO2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-CO-(CH2)12-CO2H <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 395 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Tyr Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 396 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-CO-(CH2)12-CO2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-CO-(CH2)12-CO2H <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 396 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Val Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 397 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-CO-(CH2)12-CO2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-CO-(CH2)12-CO2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 397 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 398 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-CO-(CH2)12-CO2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-CO-(CH2)12-CO2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 398 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Tyr Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 399 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-CO-(CH2)12-CO2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-CO-(CH2)12-CO2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 399 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Val Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 400 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-CO-(CH2)12-CO2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-CO-(CH2)12-CO2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 400 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Val Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Gln Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 401 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is Orn <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 401 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Gln Ala Gln Xaa Xaa Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 402 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(10-(4-carboxyphenoxy)dec anoyl) <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(10-(4-carboxyphenoxy)dec anoyl) <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 402 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Lys Phe Ile Lys Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 403 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(10-(4-carboxyphenoxy)dec anoyl) <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(10-(4-carboxyphenoxy)dec anoyl) <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 403 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Tyr Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 404 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(10-(4-carboxyphenoxy)dec anoyl) <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(10-(4-carboxyphenoxy)dec anoyl) <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 404 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Val Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 405 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(10-(4-carboxyphenoxy)dec anoyl) <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(10-(4-carboxyphenoxy)dec anoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 405 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 406 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(10-(4-carboxyphenoxy)dec anoyl) <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(10-(4-carboxyphenoxy)dec anoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 406 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Tyr Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 407 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(10-(4-carboxyphenoxy)dec anoyl) <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(10-(4-carboxyphenoxy)dec anoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 407 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Val Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 408 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-CO-(CH2)12-CO2 H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-CO-(CH2)12-CO2 H <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 408 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Val Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 409 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-CO-(CH2)12-CO2 H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-CO-(CH2)12-CO2 H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 409 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Val Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 410 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-CO-(CH2)12-CO2 H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-CO-(CH2)12-CO2 H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 410 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Val Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 411 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is Orn <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 411 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Tyr Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Gln Ala Gln Xaa Xaa Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 412 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 412 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Tyr Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Gln Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 413 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 413 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Gln Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 414 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with PEG3-(gamma-Glu)-CO-(CH2)12-CO2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with PEG3-(gamma-Glu)-CO-(CH2)12-CO2H <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 414 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 415 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with PEG4-(gamma-Glu)-CO-(CH2)12-CO2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with PEG4-(gamma-Glu)-CO-(CH2)12-CO2H <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 415 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 416 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MISC_FEATURE <222> (28)..(28) <223> Xaa at position 28 is Orn <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 416 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Xaa Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 417 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MISC_FEATURE <222> (28)..(28) <223> Xaa at position 28 is Orn <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 417 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Val Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Xaa Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 418 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MISC_FEATURE <222> (28)..(28) <223> Xaa at position 28 is Orn <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 418 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Xaa Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 419 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MISC_FEATURE <222> (28)..(28) <223> Xaa at position 28 is Orn <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 419 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Tyr Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Xaa Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 420 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MISC_FEATURE <222> (28)..(28) <223> Xaa at position 28 is Orn <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 420 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Val Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Xaa Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 421 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 421 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Gln Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 422 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 422 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Tyr Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Gln Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 423 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MISC_FEATURE <222> (28)..(28) <223> Xaa at position 28 is Orn <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 423 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Xaa Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 424 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is Orn <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 424 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Xaa Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 425 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MOD_RES <222> (10)..(10) <223> Lys at position 10 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is 4Pal <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 425 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Lys Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Xaa Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 426 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is 4Pal <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 426 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Xaa Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 427 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MOD_RES <222> (10)..(10) <223> Lys at position 10 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is Orn <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 427 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Lys Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Xaa Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 428 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is Orn <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is amidated <400> 428 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Xaa Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> 429 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 429 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Thr Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 430 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is 4Pal <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is amidated <400> 430 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Xaa Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> 431 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MOD_RES <222> (10)..(10) <223> Lys at position 10 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)3-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)3-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 431 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Lys Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 432 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)3-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)3-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 432 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 433 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)3-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)3-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 433 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 434 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)3-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)3-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is amidated <400> 434 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> 435 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MOD_RES <222> (10)..(10) <223> Lys at position 10 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-CO-(CH2)10-CH3 <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-CO-(CH2)10-CH3 <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 435 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Lys Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 436 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-CO-(CH2)10-CH3 <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-CO-(CH2)10-CH3 <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 436 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 437 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-CO-(CH2)10-CH3 <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-CO-(CH2)10-CH3 <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 437 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 438 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-CO-(CH2)10-CH3 <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-CO-(CH2)10-CH3 <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is amidated <400> 438 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> 439 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MOD_RES <222> (10)..(10) <223> Lys at position 10 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (22)..(22) <223> Xaa at position 22 is alpha-methyl-Phe <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 439 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Lys Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Xaa Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 440 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (22)..(22) <223> Xaa at position 22 is alpha-methyl-Phe <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 440 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Lys Xaa Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 441 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (22)..(22) <223> Xaa at position 22 is alpha-methyl-Phe <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is amidated <400> 441 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Xaa Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> 442 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MOD_RES <222> (10)..(10) <223> Lys at position 10 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)3-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)3-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is Orn <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 442 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Lys Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Xaa Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 443 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)3-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)3-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MISC_FEATURE <222> (28)..(28) <223> Xaa at position 28 is Orn <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 443 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Xaa Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 444 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)3-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is Orn <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)3-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 444 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Xaa Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 445 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)3-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is Orn <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)3-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is amidated <400> 445 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Xaa Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> 446 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MOD_RES <222> (10)..(10) <223> Lys at position 10 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)3-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)3-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (22)..(22) <223> Xaa at position 22 is alpha-methyl-Phe <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 446 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Lys Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Xaa Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 447 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)3-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)3-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (22)..(22) <223> Xaa at position 22 is alpha-methyl-Phe <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 447 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Lys Xaa Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 448 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)3-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (22)..(22) <223> Xaa at position 22 is alpha-methyl-Phe <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)3-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 448 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Xaa Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 449 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)3-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (22)..(22) <223> Xaa at position 22 is alpha-methyl-Phe <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)3-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is amidated <400> 449 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Xaa Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> 450 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is Orn <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 450 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Gln Ala Gln Xaa Xaa Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 451 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is Orn <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 451 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Gly Xaa Leu Asp Xaa 1 5 10 15 Gln Ala Gln Xaa Xaa Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 452 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is Orn <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(11-(4-carbox yphenoxy)undecanoyl) <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(11-(4-carbox yphenoxy)undecanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 452 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Gln Ala Gln Xaa Xaa Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 453 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is Orn <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)14-CO 2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)14-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 453 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Gln Ala Gln Xaa Xaa Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 454 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is 4Pal <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 454 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Gln Ala Gln Xaa Xaa Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 455 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MOD_RES <222> (10)..(10) <223> Lys at position 10 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 455 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Lys Xaa Ile Xaa Leu Asp Gly 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 456 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 456 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Val Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Gln Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 457 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is Orn <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 457 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Val Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Gln Ala Gln Xaa Xaa Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 458 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is Orn <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 458 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Val Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Gln Ala Gln Xaa Xaa Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 459 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is Orn <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-Ahx-(gamma-Glu)-CO-(CH2)12 -CO2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-Ahx-(gamma-Glu)-CO-(CH2)12 -CO2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 459 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Gln Ala Gln Xaa Xaa Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 460 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is Orn <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-Aoc-(gamma-Glu)-CO-(CH2)12 -CO2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-Aoc-(gamma-Glu)-CO-(CH2)12 -CO2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 460 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Gln Ala Gln Xaa Xaa Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 461 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is Orn <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with Ahx-(2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-CO-(CH2)12 -CO2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with Ahx-(2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-CO-(CH2)12 -CO2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 461 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Gln Ala Gln Xaa Xaa Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 462 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is Orn <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with Aoc-(2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-CO-(CH2)12 -CO2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with Aoc-(2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-CO-(CH2)12 -CO2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 462 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Gln Ala Gln Xaa Xaa Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 463 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is Orn <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-Ahx-(gamma-Glu)-(10-(4-car boxyphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-Ahx-(gamma-Glu)-(10-(4-car boxyphenoxy)decanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 463 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Gln Ala Gln Xaa Xaa Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 464 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is Orn <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-Aoc-(gamma-Glu)-(10-(4-car boxyphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-Aoc-(gamma-Glu)-(10-(4-car boxyphenoxy)decanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 464 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Gln Ala Gln Xaa Xaa Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 465 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is Orn <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with Ahx-(2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-(10-(4-car boxyphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with Ahx-(2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-(10-(4-car boxyphenoxy)decanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 465 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Gln Ala Gln Xaa Xaa Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 466 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is Orn <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with Aoc-(2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-(10-(4-car boxyphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with Aoc-(2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-(10-(4-car boxyphenoxy)decanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 466 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Gln Ala Gln Xaa Xaa Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 467 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is Orn <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with PEG4-(gamma-Glu)-CO-(CH2)12-CO2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with PEG4-(gamma-Glu)-CO-(CH2)12-CO2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 467 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Gln Ala Gln Xaa Xaa Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 468 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is Orn <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with PEG3-(gamma-Glu)-CO-(CH2)12-CO2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with PEG3-(gamma-Glu)-CO-(CH2)12-CO2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 468 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Gln Ala Gln Xaa Xaa Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 469 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is Orn <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-CO-(CH2)12-CO2 H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-CO-(CH2)12-CO2 H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 469 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Gln Ala Gln Xaa Xaa Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 470 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)3-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)3-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 470 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Gln Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 471 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is Orn <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (PEG4-(gamma-Glu)-(10-(4-carboxyphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (PEG4-(gamma-Glu)-(10-(4-carboxyphenoxy)decanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 471 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Gln Ala Gln Xaa Xaa Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 472 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is Orn <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with PEG3-(gamma-Glu)-(10-(4-carboxyphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with PEG3-(gamma-Glu)-(10-(4-carboxyphenoxy)decanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 472 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Gln Ala Gln Xaa Xaa Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 473 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is Orn <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-(10-(4-carboxy phenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-(10-(4-carboxy phenoxy)decanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 473 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Gln Ala Gln Xaa Xaa Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 474 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)3-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)3-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 474 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Gln Ala Gln Xaa Glu Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 475 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-Aoc-CO-(CH2)12-CO2H <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-Aoc-CO-(CH2)12-CO2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 475 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Glu Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 476 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is Orn <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with PEG6-(gamma-Glu)-CO-(CH2)12-CO2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with PEG6-(gamma-Glu)-CO-(CH2)12-CO2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 476 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Gln Ala Gln Xaa Xaa Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 477 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is Orn <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with PEG5-(gamma-Glu)-CO-(CH2)12-CO2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with PEG5-(gamma-Glu)-CO-(CH2)12-CO2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 477 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Gln Ala Gln Xaa Xaa Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 478 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is Orn <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with PEG6-(gamma-Glu)-(10-(4-carboxyphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with PEG6-(gamma-Glu)-(10-(4-carboxyphenoxy)decanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 478 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Gln Ala Gln Xaa Xaa Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 479 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is Orn <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with PEG5-(gamma-Glu)-(10-(4-carboxyphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with PEG5-(gamma-Glu)-(10-(4-carboxyphenoxy)decanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 479 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Gln Ala Gln Xaa Xaa Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 480 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is Orn <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-Trx-(gamma-Glu)-CO-(CH2)1 2-CO2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-Trx-(gamma-Glu)-CO-(CH2)1 2-CO2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 480 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Gln Ala Gln Xaa Xaa Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 481 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is Orn <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-Trx-(gamma-Glu)-(10-(4-ca rboxyphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-Trx-(gamma-Glu)-(10-(4-ca rboxyphenoxy)decanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 481 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Gln Ala Gln Xaa Xaa Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 482 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is Orn <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-Trx-(gamma-Glu)-CO-(CH2)12 -CO2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-Trx-(gamma-Glu)-CO-(CH2)12 -CO2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 482 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Gln Ala Gln Xaa Xaa Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 483 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is Orn <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-Trx-(gamma-Glu)-(10-(4-car boxyphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-Trx-(gamma-Glu)-(10-(4-car boxyphenoxy)decanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 483 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Gln Ala Gln Xaa Xaa Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 484 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is Orn <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)2-CO-(CH2)12-C O2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)2-CO-(CH2)12-C O2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 484 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Gln Ala Gln Xaa Xaa Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 485 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is Orn <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)2-(10-(4-carbo xyphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)2-(10-(4-carbo xyphenoxy)decanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 485 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Gln Ala Gln Xaa Xaa Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 486 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is Orn <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)3-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)3-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 486 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Gln Ala Gln Xaa Xaa Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 487 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is Orn <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)3-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)3-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 487 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Gln Ala Gln Xaa Xaa Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 488 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is Orn <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)3-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)3-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 488 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Tyr Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Xaa Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 489 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is Orn <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)3-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)3-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 489 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Tyr Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Gln Ala Gln Xaa Xaa Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 490 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is Orn <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)2-CO-(CH2)12-C O2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)2-CO-(CH2)12-C O2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 490 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Tyr Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Gln Ala Gln Xaa Xaa Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 491 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is Orn <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)3-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)3-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 491 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Tyr Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Ile Ala Gln Xaa Xaa Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 492 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is Orn <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (gamma-Glu)-(2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-C O-(CH2)12-CO2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (gamma-Glu)-(2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-C O-(CH2)12-CO2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 492 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Gln Ala Gln Xaa Xaa Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 493 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is Orn <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (gamma-Glu)-(2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-( 10-(4-carboxyphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (gamma-Glu)-(2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-( 10-(4-carboxyphenoxy)decanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 493 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Gln Ala Gln Xaa Xaa Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 494 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is Orn <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-(2-[2-(2-amino -ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-CO-(CH2)12-CO2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-(2-[2-(2-amino -ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-CO-(CH2)12-CO2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 494 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Gln Ala Gln Xaa Xaa Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 495 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is Orn <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-(2-[2-(2-amino -ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-(10-(4-carboxyphenoxy)decano <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-(2-[2-(2-amino -ethoxy)-ethoxy]-acetyl)-(gamma-Glu)-(10-(4-carboxyphenoxy)decano <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 495 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Gln Ala Gln Xaa Xaa Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 496 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is Orn <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)3-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)3-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 496 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Gln Ala Gln Xaa Xaa Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 497 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is Orn <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)3-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)-(gamma-Glu)3-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 497 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Gln Ala Gln Xaa Xaa Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 498 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 498 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Gln Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 499 <211> 40 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is AIB <220> <221> MOD_RES <222> (21)..(21) <223> Lys at position 21 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (40)..(40) <223> Lys at position 40 is amidated <400> 499 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Gln Ala Gln Xaa Lys Phe Ile Xaa Xaa Leu Ile Glu Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser Lys 35 40 <210> 500 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is Nle <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is Orn <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 500 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Gln Ala Gln Xaa Xaa Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 501 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is hTyr <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is Orn <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)12-CO 2H <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 501 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Ile Xaa Leu Asp Xaa 1 5 10 15 Gln Ala Gln Xaa Xaa Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 502 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is Orn <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 502 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Tyr Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Gln Ala Gln Xaa Xaa Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 503 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is 4Pal <220> <221> MOD_RES <222> (24)..(24) <223> Lys at position 24 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-(10-(4-carbox yphenoxy)decanoyl) <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 503 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Gln Ala Gln Xaa Xaa Phe Ile Lys Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 504 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 is alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is 4Pal <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is Aib <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is alpha-methyl-Leu <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MOD_RES <222> (17)..(17) <223> Lys at position 17 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is Aib <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is D-Glu <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is alpha-methyl-Tyr <220> <221> MOD_RES <222> (28)..(28) <223> Lys at position 28 is chemically modified by conjugation of the epsilon-amino group of the Lys side chain with (2-[2-(2-amino-ethoxy)-ethoxy]-acetyl)2-(gamma-Glu)-CO-(CH2)10-CH 3 <220> <221> MOD_RES <222> (39)..(39) <223> Ser at position 39 is amidated <400> 504 Tyr Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Ile Xaa Leu Asp Xaa 1 5 10 15 Lys Ala Gln Xaa Gly Phe Ile Xaa Xaa Leu Ile Lys Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 505 <211> 30 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct; a compound of Formula I <220> <221> MISC_FEATURE <222> (1)..(1) <223> Xaa at position 1 selected from the group consisting of Y or R1Y, wherein R1 is an acetyl modification of the N-terminal amino group of Y <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa at position 2 is Aib <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa at position 6 iis selected from the group consisting of alpha-methyl-Phe and alpha-methyl-Phe(2F) <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is selected from the group consisting of 4Pal, Y, alpha-methyl-Phe, alpha-methyl-Phe(2F), alpha-methyl-Leu, alpha-methyl-Val, Ac4c, Ac5c, Ac6c, Bip, 1Nal, 2Nal, OMeY, hTyr, Nle, V, 4CPhe, ChG, ChA, Bzt, 2FA, 4TAA, 2TA, 3TA, and KZ1 <220> <221> MISC_FEATURE <222> (10)..(10) <223> Z1 is selected from the group consisting of R5 and -R4R5; R4 is a linker; and R5 is a fatty acid <220> <221> MISC_FEATURE <222> (10)..(30) <223> wherein two, and only two, of X10, X12, X17, X21, X24, X25, X28, X30, X31, and X40 are KZ1 or K(Z1)R6 <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa at position 11 is selected from the group consisting of S, alpha-methyl-Ser, Aib, G, Dap, Ac5c, and Tle <220> <221> MISC_FEATURE <222> (12)..(12) <223> Xaa at position 12 is selected from the group consisting of I and KZ1 <220> <221> MISC_FEATURE <222> (12)..(12) <223> Z1 is selected from the group consisting of R5 and -R4R5; R4 is a linker; and R5 is a fatty acid <220> <221> MISC_FEATURE <222> (13)..(13) <223> Xaa at position 13 is selected from the group consisting of alpha-methyl-Leu and alpha-methyl-Phe <220> <221> MISC_FEATURE <222> (16)..(16) <223> Xaa at position 16 is Orn <220> <221> MISC_FEATURE <222> (17)..(17) <223> Xaa at position 17 is selected from the group consisting of Q, I, and KZ1 <220> <221> MISC_FEATURE <222> (17)..(17) <223> Z1 is selected from the group consisting of R5 and -R4R5; R4 is a linker; and R5 is a fatty acid <220> <221> MISC_FEATURE <222> (20)..(20) <223> Xaa at position 20 is selected from the group consisting of Aib, Orn, 4Pal, alpha-methyl-Phe, Ac5c, and Ac6c <220> <221> MISC_FEATURE <222> (21)..(21) <223> Xaa at position 21 is selected from the group consisting of E, KZ1, G, Orn, and 4Pal <220> <221> MISC_FEATURE <222> (21)..(21) <223> Z1 is selected from the group consisting of R5 and -R4R5; R4 is a linker; and R5 is a fatty acid <220> <221> MISC_FEATURE <222> (22)..(22) <223> Xaa at position 22 is selected from the group consisting of F, 2ClPhe, 3ClPhe, 2FPhe, 3FPhe, 3,5FPhe, 1Nal, 2Nal, alpha-methyl-Phe(2F), ChA, Bzt, and alpha-methyl-Phe <220> <221> MISC_FEATURE <222> (24)..(24) <223> Xaa at position 24 is selected from the group consisting of D-Glu, E, G, and KZ1 <220> <221> MISC_FEATURE <222> (24)..(24) <223> Z1 is selected from the group consisting of R5 and -R4R5; R4 is a linker; and R5 is a fatty acid <220> <221> MISC_FEATURE <222> (25)..(25) <223> Xaa at position 25 is selected from the group consisting of Y, alpha-methyl-Tyr, alpha-methyl-Phe, and KZ1 <220> <221> MISC_FEATURE <222> (25)..(25) <223> Z1 is selected from the group consisting of R5 and -R4R5; R4 is a linker; and R5 is a fatty acid <220> <221> MISC_FEATURE <222> (28)..(28) <223> Xaa at position 28 is selected from the group consisting of E, Orn, and KZ1 <220> <221> MISC_FEATURE <222> (28)..(28) <223> Z1 is selected from the group consisting of R5 and -R4R5; R4 is a linker; and R5 is a fatty acid <220> <221> MISC_FEATURE <222> (30)..(30) <223> Xaa at position 30 is selected from the group consisting of G, Orn, KZ1, K(Z1)R6, OrnR2, and GR2 <220> <221> MISC_FEATURE <222> (30)..(30) <223> R2 is selected from the group consisting of X31, SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9, SEQ ID NO:10, and a modification of the C-terminal group wherein the modification is NH2 <220> <221> MISC_FEATURE <222> (30)..(30) <223> R6 is selected from the group consisting of SEQ ID NO:506, SEQ ID NO:507, SEQ ID NO:508, SEQ ID NO:509, SEQ ID NO:510, SEQ ID NO:511, and a modification of the C-terminal group wherein the modification is NH2 <220> <221> MISC_FEATURE <222> (30)..(30) <223> X31 is selected from the group consisting of P and KZ1; X35 is selected from the group consisting of A and Orn; X39 is selected from the group consisting of S and Orn; X40 is KZ1 <220> <221> MISC_FEATURE <222> (30)..(30) <223> R3 is a modification of the C-terminal group, wherein the modification is NH2 <220> <221> MISC_FEATURE <222> (30)..(30) <223> Z1 is selected from the group consisting of R5 and -R4R5; R4 is a linker; and R5 is a fatty acid <400> 505 Xaa Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Xaa Xaa Xaa Leu Asp Xaa 1 5 10 15 Xaa Ala Gln Xaa Xaa Xaa Ile Xaa Xaa Leu Ile Xaa Gly Xaa 20 25 30 <210> 506 <211> 4 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 506 Pro Ser Ser Gly 1 <210> 507 <211> 4 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MOD_RES <222> (4)..(4) <223> Gly is modified with R3; wherein R3 is a modification of the C-terminal group, wherein the modification is NH2 <400> 507 Pro Ser Ser Gly 1 <210> 508 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (5)..(5) <223> Xaa at position 5 is selected from the group consisting of A and Orn <220> <221> MISC_FEATURE <222> (9)..(9) <223> Xaa at position 9 is selected from the group consisting of S and Orn <400> 508 Pro Ser Ser Gly Xaa Pro Pro Pro Xaa 1 5 <210> 509 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (5)..(5) <223> Xaa at position 5 is selected from the group consisting of A and Orn <220> <221> MISC_FEATURE <222> (9)..(9) <223> Xaa at position 9 is selected from the group consisting of S and Orn <220> <221> MOD_RES <222> (9)..(9) <223> Xaa at position 9 is modified with R3; wherein R3 is a modification of the C-terminal group, wherein the modification is NH2 <400> 509 Pro Ser Ser Gly Xaa Pro Pro Pro Xaa 1 5 <210> 510 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (5)..(5) <223> Xaa at position 5 is selected from the group consisting of A and Orn <220> <221> MISC_FEATURE <222> (9)..(9) <223> Xaa at position 9 is selected from the group consisting of S and Orn <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is KZ1; wherein Z1 is selected from the group consisting of R5 and -R4R5; R4 is a linker; and R5 is a fatty acid <400> 510 Pro Ser Ser Gly Xaa Pro Pro Pro Xaa Xaa 1 5 10 <210> 511 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <220> <221> MISC_FEATURE <222> (5)..(5) <223> Xaa at position 5 is selected from the group consisting of A and Orn <220> <221> MISC_FEATURE <222> (9)..(9) <223> Xaa at position 9 is selected from the group consisting of S and Orn <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is KZ1; wherein Z1 is selected from the group consisting of R5 and -R4R5; R4 is a linker; and R5 is a fatty acid <220> <221> MISC_FEATURE <222> (10)..(10) <223> Xaa at position 10 is modified with R3; wherein R3 is a modification of the C-terminal group, wherein the modification is NH2 <400> 511 Pro Ser Ser Gly Xaa Pro Pro Pro Xaa Xaa 1 5 10

Claims

하기 화학식의 화합물 또는 그의 제약상 허용되는 염:
X₁X₂EGTX₆TSDX₁₀X₁₁X₁₂X₁₃LDX₁₆X₁₇AQX₂₀X₂₁X₂₂IX₂₄X₂₅LIX₂₈GX₃₀
(서열식별번호: 505)
여기서
X₁은 Y 및 R₁Y로 이루어진 군으로부터 선택되고;
R₁은 N-말단 아미노 기의 Ac 변형이고;
X₂는 Aib이고;
X₆은 αMeF 및 αMeF(2F)로 이루어진 군으로부터 선택되고;
X₁₀은 4Pal, Y, αMeF, αMeF(2F), αMeL, αMeV, Ac4c, Ac5c, Ac6c, Bip, 1Nal, 2Nal, OMeY, hTyr, Nle, V, 4CPhe, ChG, ChA, Bzt, 2FA, 4TAA, 2TA, 3TA, 및 KZ₁로 이루어진 군으로부터 선택되고;
X₁₁은 S, αMeS, Aib, G, Dap, Ac5c, 및 Tle로 이루어진 군으로부터 선택되고;
X₁₂는 I 및 KZ₁로 이루어진 군으로부터 선택되고;
X₁₃은 αMeL 및 αMeF로 이루어진 군으로부터 선택되고;
X₁₆은 Orn이고;
X₁₇은 Q, I, 및 KZ₁로 이루어진 군으로부터 선택되고;
X₂₀은 Aib, Orn, 4Pal, αMeF, Ac5c, 및 Ac6c로 이루어진 군으로부터 선택되고;
X₂₁은 E, KZ₁, G, Orn, 및 4Pal로 이루어진 군으로부터 선택되고;
X₂₂는 F, 2ClPhe, 3ClPhe, 2FPhe, 3FPhe, 3,5FPhe, 1Nal, 2Nal, αMeF(2F), ChA, Bzt, 및 αMeF로 이루어진 군으로부터 선택되고;
X₂₄는 D-Glu, E, G, 및 KZ₁로 이루어진 군으로부터 선택되고;
X₂₅는 Y, αMeY, αMeF, 및 KZ₁로 이루어진 군으로부터 선택되고;
X₂₈은 E, Orn, 및 KZ₁로 이루어진 군으로부터 선택되고;
X₃₀은 G, Orn, KZ₁, K(Z₁)R₆, OrnR₂, 및 GR₂로 이루어진 군으로부터 선택되고;
R₂는 X₃₁, X₃₁SSG(서열식별번호: 5), X₃₁SSG-R₃ (서열식별번호: 6), X₃₁SSGX₃₅PPPX₃₉ (서열식별번호: 7), X₃₁SSGX₃₅PPPX₃₉R₃ (서열식별번호: 8), X₃₁SSGX₃₅PPPX₃₉X₄₀ (서열식별번호: 9), X₃₁SSGX₃₅PPPX₃₉X₄₀R₃ (서열식별번호: 10), 및 변형이 NH₂인 c-말단 기의 변형으로 이루어진 군으로부터 선택되고;
R₆은 PSSG(서열식별번호: 506), PSSG-R₃ (서열식별번호: 507), PSSGX₃₅PPPX₃₉ (서열식별번호: 508), PSSGX₃₅PPPX₃₉R₃ (서열식별번호: 509), PSSGX₃₅PPPX₃₉X₄₀ (서열식별번호: 510), PSSGX₃₅PPPX₃₉X₄₀R₃ (서열식별번호: 511), 및 변형이 NH₂인 c-말단 기의 변형으로 이루어진 군으로부터 선택되고;
X₃₁은 P 및 KZ₁로 이루어진 군으로부터 선택되고;
X₃₅는 A 및 Orn으로 이루어진 군으로부터 선택되고;
X₃₉는 S 및 Orn으로 이루어진 군으로부터 선택되고;
X₄₀은 KZ₁이고;
R₃은 변형이 NH₂인 C-말단 기의 변형이고;
여기서 X₁₀, X₁₂, X₁₇, X₂₁, X₂₄, X₂₅, X₂₈, X₃₀, X₃₁, 및 X₄₀ 중 2개, 및 오직 2개는 KZ₁ 또는 K(Z₁)R₆이고;
Z₁은 R₅ 및 -R₄R₅로 이루어진 군으로부터 선택되고;
R₄는 링커이고;
R₅는 지방산이다.
제1항에 있어서,
X₃₀이 G, Orn, KZ₁, 및 GR₂로 이루어진 군으로부터 선택되고;
R₂가 X₃₁SSG(서열식별번호: 5), X₃₁SSG-R₃ (서열식별번호: 6), X₃₁SSGX₃₅PPPX₃₉ (서열식별번호: 7), X₃₁SSGX₃₅PPPX₃₉R₃ (서열식별번호: 8), X₃₁SSGX₃₅PPPX₃₉X₄₀ (서열식별번호: 9), X₃₁SSGX₃₅PPPX₃₉X₄₀R₃ (서열식별번호: 10), 및 변형이 NH₂인 c-말단 기의 변형으로 이루어진 군으로부터 선택된 것인
화합물 또는 그의 제약상 허용되는 염.
제1항 또는 제2항에 있어서, Z₁이 -R₄R₅인 화합물 또는 그의 제약상 허용되는 염.
제1항 내지 제3항 중 어느 한 항에 있어서, R₅가 -CO-(CH₂)₁₂-CO₂H, CO-(CH₂)₁₄-CO₂H, -CO-(CH₂)₁₀-CO₂H, -(10-(4-카르복시페녹시)데카노일), -(4-(4-아이오도페닐)부타노일), -(4-(4-tert-부틸페닐)부타노일), -CO-(CH₂)₁₄-CH₃, -CO-(CH₂)₁₂-CH₃, -CO-(CH₂)₁₀-CH₃, -(7-(4-카르복시페녹시)헵타노일), -(11-(4-카르복시페녹시)운데카노일), -(12-(4-카르복시페녹시)도데카노일), 및 -(8-(4-카르복시페녹시)옥타노일)로 이루어진 군으로부터 선택된 것인 화합물 또는 그의 제약상 허용되는 염.
제1항 내지 제4항 중 어느 한 항에 있어서, R₅가 -CO-(CH₂)₁₂-CO₂H, -CO-(CH₂)₁₀-CO₂H, -(10-(4-카르복시페녹시)데카노일), -(4-(4-아이오도페닐)부타노일), -(4-(4-tert-부틸페닐)부타노일), -CO-(CH₂)₁₄-CH₃, -CO-(CH₂)₁₂-CH₃, -CO-(CH₂)₁₀-CH₃, -(7-(4-카르복시페녹시)헵타노일), 및 -(8-(4-카르복시페녹시)옥타노일)로 이루어진 군으로부터 선택된 것인 화합물 또는 그의 제약상 허용되는 염.
제1항 내지 제4항 중 어느 한 항에 있어서, R₅가 CO-(CH₂)₁₄-CO₂H, -(11-(4-카르복시페녹시)운데카노일), 및 -(12-(4-카르복시페녹시)도데카노일)로 이루어진 군으로부터 선택된 것인 화합물 또는 그의 제약상 허용되는 염.
제1항 내지 제6항 중 어느 한 항에 있어서, R₄가 -(εK)_a1-(γ-Glu)_a2-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)_a3-(εK)_b1-(γ-Glu)_b2-이고;
a1이 0, 1, 및 2로 이루어진 군으로부터 선택되고;
a2가 0, 1, 및 2로 이루어진 군으로부터 선택되고;
a3이 0, 1, 2, 및 3으로 이루어진 군으로부터 선택되고;
b1이 0 또는 1이고;
b2가 0 또는 1인
화합물 또는 그의 제약상 허용되는 염.
제1항 내지 제6항 중 어느 한 항에 있어서, R₄가
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-,
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-,
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(γ-Glu)-,
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)₂)-,
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₃-(γ-Glu)-,
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(εK)-,
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(εK)-(γ-Glu)-,
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(εK)-(γ-Glu)-,
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-Trx-(γ-Glu)-,
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-Trx-(γ-Glu)-,
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-Aoc-,
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-Aoc-(γ-Glu)-,
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-Ahx-(γ-Glu)-,
-PEG3-(γ-Glu)-,
-PEG4-(γ-Glu)-,
-PEG5-(γ-Glu)-,
-PEG6-(γ-Glu)-,
-Ahx-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(γ-Glu)-,
-Aoc-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(γ-Glu)-,
-(εK)-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(γ-Glu)-,
-(εK)-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-,
-(εK)-(γ-Glu)-,
-(εK)-(γ-Glu)-(γ-Glu)-,
-(γ-Glu)-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-,
-(εK)-(εK)-(γ-Glu)-,
-(γ-Glu)-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-,
-(γ-Glu)-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-,
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(γ-Glu)-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-,
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-,
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(γ-Glu)-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-, 및
(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(γ-Glu)-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(γ-Glu)-
로 이루어진 군으로부터 선택된 것인 화합물 또는 그의 제약상 허용되는 염.
제1항 내지 제6항 중 어느 한 항에 있어서, R₄가
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-,
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-,
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(γ-Glu)-,
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₃-(γ-Glu)-,
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(εK)-,
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(εK)-(γ-Glu)-,
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(εK)-(γ-Glu)-,
-(εK)-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(γ-Glu)-,
-(εK)-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-,
-(εK)-(γ-Glu)-,
-(εK)-(γ-Glu)-(γ-Glu)-,
-(γ-Glu)-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-,
-(εK)-(εK)-(γ-Glu)-,
-(γ-Glu)-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-, 및
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(γ-Glu)-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-
로 이루어진 군으로부터 선택된 것인 화합물 또는 그의 제약상 허용되는 염.
제2항 및 제4항 내지 제9항 중 어느 한 항에 있어서, Z₁이
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-CO-(CH₂)₁₂-CO₂H,
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-CO-(CH₂)₁₀-CO₂H,
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-(10-(4-카르복시페녹시)데카노일),
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-(4-(4-아이오도페닐)부타노일),
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-(4-(4-tert-부틸페닐)부타노일),
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-CO-(CH₂)₁₄-CH₃,
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-CO-(CH₂)₁₂-CH₃,
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-CO-(CH₂)₁₀-CH₃,
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-CO-(CH₂)₁₂-CO₂H,
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(10-(4-카르복시페녹시)데카노일),
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(γ-Glu)-CO-(CH₂)₁₂-CO₂H,
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(γ-Glu)-(10-(4-카르복시페녹시)데카노일),
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(γ-Glu)-CO-(CH₂)₁₄-CH₃,
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(γ-Glu)-CO-(CH₂)₁₀-CH₃,
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₃-(γ-Glu)-CO-(CH₂)₁₂-CO₂H,
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₃-(γ-Glu)-CO-(CH₂)₁₄-CH₃,
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(εK)-CO-(CH₂)₁₂-CO₂H,
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(εK)-(γ-Glu)-CO-(CH₂)₁₂-CO₂H,
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(εK)-(γ-Glu)-CO-(CH₂)₁₂-CO₂H,
-(εK)-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(γ-Glu)-CO-(CH₂)₁₂-CO₂H,
-(εK)-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-CO-(CH₂)₁₂-CO₂H,
-(εK)-(γ-Glu)-CO-(CH₂)₁₂-CO₂H,
-(εK)-(γ-Glu)-(γ-Glu)-CO-(CH₂)₁₂-CO₂H,
-(γ-Glu)-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-CO-(CH₂)₁₂-CO₂H,
-(εK)-(εK)-(γ-Glu)-CO-(CH₂)₁₂-CO₂H,
-(γ-Glu)-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-CO-(CH₂)₁₂-CO₂H,
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(γ-Glu)-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-CO-(CH₂)₁₂-CO₂H,
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-(7-(4-카르복시페녹시)헵타노일),
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-(8-(4-카르복시페녹시)옥타노일),
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(γ-Glu)-(4-(4-tert-부틸페닐)부타노일),
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-(11-(4-카르복시페녹시)운데카노일),
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₃-(γ-Glu)-(10-(4-카르복시페녹시)데카노일),
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-CO-(CH₂)₁₂-CO₂H,
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(γ-Glu)-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-CO-(CH₂)₁₂-CO₂H,
-PEG3-(γ-Glu)-CO-(CH₂)₁₂-CO₂H,
-PEG4-(γ-Glu)-CO-(CH₂)₁₂-CO₂H,
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₃-(γ-Glu)-CO-(CH₂)₁₀-CH₃,
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-(11-(4-카르복시페녹시)운데카노일,
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-CO-(CH₂)₁₄-CO₂H,
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-Ahx-(γ-Glu)-CO-(CH₂)₁₂-CO₂H,
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-Aoc-(γ-Glu)-CO-(CH₂)₁₂-CO₂H,
-Ahx-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(γ-Glu)-CO-(CH₂)₁₂-CO₂H,
-Aoc-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(γ-Glu)-CO-(CH₂)₁₂-CO₂H,
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-Ahx-(γ-Glu)-(10-(4-카르복시페녹시)데카노일),
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-Aoc-(γ-Glu)-(10-(4-카르복시페녹시)데카노일),
-Ahx-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(γ-Glu)-(10-(4-카르복시페녹시)데카노일),
-Aoc-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(γ-Glu)-(10-(4-카르복시페녹시)데카노일),
-PEG4-(γ-Glu)-(10-(4-카르복시페녹시)데카노일),
-PEG3-(γ-Glu)-(10-(4-카르복시페녹시)데카노일),
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-Aoc-CO-(CH₂)₁₂-CO₂H,
-PEG6-(γ-Glu)-CO-(CH₂)₁₂-CO₂H,
-PEG5-(γ-Glu)-CO-(CH₂)₁₂-CO₂H,
-PEG6-(γ-Glu)-(10-(4-카르복시페녹시)데카노일),
-PEG5-(γ-Glu)-(10-(4-카르복시페녹시)데카노일),
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-Trx-(γ-Glu)-CO-(CH₂)₁₂-CO₂H,
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-Trx-(γ-Glu)-(10-(4-카르복시페녹시)데카노일),
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-Trx-(γ-Glu)-CO-(CH₂)₁₂-CO₂H,
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-Trx-(γ-Glu)-(10-(4-카르복시페녹시)데카노일),
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)₂-CO-(CH₂)₁₂-CO₂H,
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)₂-(10-(4-카르복시페녹시)데카노일),
-(γ-Glu)-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-CO-(CH₂)₁₂-CO₂H,
-(γ-Glu)-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-(10-(4-카르복시페녹시)데카노일),
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(γ-Glu)-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(γ-Glu)-CO-(CH₂)₁₂-CO₂H, 및
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(γ-Glu)-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(γ-Glu)-(10-(4-카르복시페녹시)데카노일)
로 이루어진 군으로부터 선택된 것인 화합물 또는 그의 제약상 허용되는 염.
제10항에 있어서, Z₁이
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-CO-(CH₂)₁₂-CO₂H,
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-CO-(CH₂)₁₀-CO₂H,
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-(10-(4-카르복시페녹시)데카노일),
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-(4-(4-아이오도페닐)부타노일),
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-(4-(4-tert-부틸페닐)부타노일),
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-CO-(CH₂)₁₄-CH₃,
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-CO-(CH₂)₁₂-CH₃,
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-CO-(CH₂)₁₀-CH₃,
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-CO-(CH₂)₁₂-CO₂H,
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(10-(4-카르복시페녹시)데카노일),
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(γ-Glu)-CO-(CH₂)₁₂-CO₂H,
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(γ-Glu)-(10-(4-카르복시페녹시)데카노일),
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(γ-Glu)-CO-(CH₂)₁₄-CH₃,
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(γ-Glu)-CO-(CH₂)₁₀-CH₃,
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₃-(γ-Glu)-CO-(CH₂)₁₂-CO₂H,
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₃-(γ-Glu)-CO-(CH₂)₁₄-CH₃,
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(εK)-CO-(CH₂)₁₂-CO₂H,
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(εK)-(γ-Glu)-CO-(CH₂)₁₂-CO₂H,
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(εK)-(γ-Glu)-CO-(CH₂)₁₂-CO₂H,
-(εK)-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(γ-Glu)-CO-(CH₂)₁₂-CO₂H,
-(εK)-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-CO-(CH₂)₁₂-CO₂H,
-(εK)-(γ-Glu)-CO-(CH₂)₁₂-CO₂H,
-(εK)-(γ-Glu)-(γ-Glu)-CO-(CH₂)₁₂-CO₂H,
-(γ-Glu)-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-CO-(CH₂)₁₂-CO₂H,
-(εK)-(εK)-(γ-Glu)-CO-(CH₂)₁₂-CO₂H,
-(γ-Glu)-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-CO-(CH₂)₁₂-CO₂H,
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(γ-Glu)-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-CO-(CH₂)₁₂-CO₂H,
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-(7-(4-카르복시페녹시)헵타노일),
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-(8-(4-카르복시페녹시)옥타노일), 및
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(γ-Glu)-(4-(4-tert-부틸페닐)부타노일)
로 이루어진 군으로부터 선택된 것인 화합물 또는 그의 제약상 허용되는 염.
제10항에 있어서, Z₁이
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-(11-(4-카르복시페녹시)운데카노일),
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₃-(γ-Glu)-(10-(4-카르복시페녹시)데카노일),
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-CO-(CH₂)₁₂-CO₂H,
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(γ-Glu)-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-CO-(CH₂)₁₂-CO₂H,
-PEG3-(γ-Glu)-CO-(CH₂)₁₂-CO₂H,
-PEG4-(γ-Glu)-CO-(CH₂)₁₂-CO₂H,
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₃-(γ-Glu)-CO-(CH₂)₁₀-CH₃,
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-(11-(4-카르복시페녹시)운데카노일,
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-CO-(CH₂)₁₄-CO₂H,
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-Ahx-(γ-Glu)-CO-(CH₂)₁₂-CO₂H,
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-Aoc-(γ-Glu)-CO-(CH₂)₁₂-CO₂H,
-Ahx-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(γ-Glu)-CO-(CH₂)₁₂-CO₂H,
-Aoc-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(γ-Glu)-CO-(CH₂)₁₂-CO₂H,
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-Ahx-(γ-Glu)-(10-(4-카르복시페녹시)데카노일),
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-Aoc-(γ-Glu)-(10-(4-카르복시페녹시)데카노일),
-Ahx-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(γ-Glu)-(10-(4-카르복시페녹시)데카노일),
-Aoc-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(γ-Glu)-(10-(4-카르복시페녹시)데카노일),
-PEG4-(γ-Glu)-(10-(4-카르복시페녹시)데카노일),
-PEG3-(γ-Glu)-(10-(4-카르복시페녹시)데카노일),
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-Aoc-CO-(CH₂)₁₂-CO₂H,
-PEG6-(γ-Glu)-CO-(CH₂)₁₂-CO₂H,
-PEG5-(γ-Glu)-CO-(CH₂)₁₂-CO₂H,
-PEG6-(γ-Glu)-(10-(4-카르복시페녹시)데카노일),
-PEG5-(γ-Glu)-(10-(4-카르복시페녹시)데카노일),
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-Trx-(γ-Glu)-CO-(CH₂)₁₂-CO₂H,
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-Trx-(γ-Glu)-(10-(4-카르복시페녹시)데카노일),
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-Trx-(γ-Glu)-CO-(CH₂)₁₂-CO₂H,
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-Trx-(γ-Glu)-(10-(4-카르복시페녹시)데카노일),
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)₂-CO-(CH₂)₁₂-CO₂H,
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)₂-(10-(4-카르복시페녹시)데카노일),
-(γ-Glu)-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-CO-(CH₂)₁₂-CO₂H,
-(γ-Glu)-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-(10-(4-카르복시페녹시)데카노일),
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(γ-Glu)-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(γ-Glu)-CO-(CH₂)₁₂-CO₂H, 및
-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(γ-Glu)-(2-[2-(2-아미노-에톡시)-에톡시]-아세틸)-(γ-Glu)-(10-(4-카르복시페녹시)데카노일)
로 이루어진 군으로부터 선택된 것인 화합물 또는 그의 제약상 허용되는 염.
제1항 내지 제12항 중 어느 한 항에 있어서,
X₁이 Y이고;
X₆이 αMeF(2F)이고;
X₁₀이 4Pal, Y, 및 KZ₁로 이루어진 군으로부터 선택되고;
X₁₁이 S, αMeS, 및 Aib로 이루어진 군으로부터 선택되고;
X₁₂가 I이고;
X₁₃이 αMeL이고;
X₁₆이 Orn이고;
X₁₇이 I 및 KZ₁로 이루어진 군으로부터 선택되고;
X₂₀이 Aib이고;
X₂₁이 E 또는 KZ₁이고;
X₂₂가 F 및 αMeF로 이루어진 군으로부터 선택되고;
X₂₄가 D-Glu 및 KZ₁로 이루어진 군으로부터 선택되고;
X₂₅가 αMeY이고;
X₂₈이 E 및 KZ₁로 이루어진 군으로부터 선택되고;
X₃₀이 G 및 GR₂로 이루어진 군으로부터 선택되고;
R₂가 X₃₁SSGX₃₅PPPX₃₉ (서열식별번호: 7), X₃₁SSGX₃₅PPPX₃₉R₃ (서열식별번호: 8), 및 X₃₁SSGX₃₅PPPX₃₉X₄₀ (서열식별번호: 9), 및 변형이 NH₂인 c-말단 기의 변형으로 이루어진 군으로부터 선택된 것인
화합물 또는 그의 제약상 허용되는 염 또는 그의 제약상 허용되는 염.
제1항 내지 제13항 중 어느 한 항에 있어서,
X₃₀이 GR₂이고;
R₂가 X₃₁SSGX₃₅PPPX₃₉ (서열식별번호: 7), X₃₁SSGX₃₅PPPX₃₉R₃ (서열식별번호: 8), 및 X₃₁SSGX₃₅PPPX₃₉X₄₀ (서열식별번호: 9)으로 이루어진 군으로부터 선택된 것인
화합물 또는 그의 제약상 허용되는 염.
제1항 내지 제14항 중 어느 한 항에 있어서, X₁₇ 및 X₃₁이 각각 KZ₁인 화합물 또는 그의 제약상 허용되는 염.
제1항 내지 제14항 중 어느 한 항에 있어서, X₁₇ 및 X₂₄가 각각 KZ₁인 화합물 또는 그의 제약상 허용되는 염.
제1항 내지 제14항 중 어느 한 항에 있어서, X₁₇ 및 X₂₁이 각각 KZ₁인 화합물 또는 그의 제약상 허용되는 염.
제1항 내지 제14항 중 어느 한 항에 있어서, X₁₇ 및 X₂₈이 각각 KZ₁인 화합물 또는 그의 제약상 허용되는 염.
제1항 내지 제14항 중 어느 한 항에 있어서, X₂₁ 및 X₂₈이 각각 KZ₁인 화합물 또는 그의 제약상 허용되는 염.
제1항 내지 제14항 중 어느 한 항에 있어서, X₂₄ 및 X₂₈이 각각 KZ₁인 화합물 또는 그의 제약상 허용되는 염.
제1항 내지 제14항 중 어느 한 항에 있어서, X₁₇ 및 X₄₀이 각각 KZ₁인 화합물 또는 그의 제약상 허용되는 염.
제1항 내지 제14항 중 어느 한 항에 있어서, X₂₁ 및 X₄₀이 각각 KZ₁인 화합물 또는 그의 제약상 허용되는 염.
제1항에 있어서, 화합물이
Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-CO-(CH₂)₁₂-CO₂H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-CO-(CH₂)₁₂-CO₂H)SSGAPPPS-NH₂,
Y-Aib-EGT-aMeF(2F)-TSD-4Pal-SI-aMeL-LD-Orn-K((2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-(10-(4-카르복시페녹시)데카노일))AQ-Aib-EFI-(D-Glu)-aMeY-LIEGGK((2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-(10-(4-카르복시페녹시)데카노일))SSGAPPPS-NH₂,
Y-Aib-EGT-aMeF(2F)-TSD-4Pal-SI-aMeL-LD-Orn-K((2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-(4-(4-아이오도페닐)부타노일))AQ-Aib-EFI-(D-Glu)-aMeY-LIEGGK((2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-(4-(4-아이오도페닐)부타노일))SSGAPPPS-NH₂,
Y-Aib-EGT-aMeF(2F)-TSD-4Pal-SI-aMeL-LD-Orn-K((2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-(4-(4-tert-부틸페닐)부타노일))AQ-Aib-EFI-(D-Glu)-aMeY-LIEGGK((2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-(4-(4-tert-부틸페닐)부타노일))SSGAPPPS-NH₂, 및
Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-CO-(CH₂)₁₀-CH3)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-CO-(CH₂)₁₀-CH₃)SSGAPPPS-NH₂
로 이루어진 군으로부터 선택된 것인 화합물 또는 그의 제약상 허용되는 염.
제23항에 있어서, 화합물이 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-CO-(CH₂)₁₀-CH₃)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-CO-(CH₂)₁₀-CH₃)SSGAPPPS-NH₂인 화합물 또는 그의 제약상 허용되는 염.
제23항에 있어서, 화합물이 Y-Aib-EGT-aMeF(2F)-TSD-4Pal-SI-aMeL-LD-Orn-K((2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-(4-(4-tert-부틸페닐)부타노일))AQ-Aib-EFI-(D-Glu)-aMeY-LIEGGK((2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-(4-(4-tert-부틸페닐)부타노일))SSGAPPPS-NH₂인 화합물 또는 그의 제약상 허용되는 염.
제23항에 있어서, 화합물이 Y-Aib-EGT-aMeF(2F)-TSD-4Pal-SI-aMeL-LD-Orn-K((2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-(4-(4-아이오도페닐)부타노일))AQ-Aib-EFI-(D-Glu)-aMeY-LIEGGK((2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-(4-(4-아이오도페닐)부타노일))SSGAPPPS-NH₂인 화합물 또는 그의 제약상 허용되는 염.
제23항에 있어서, 화합물이 Y-Aib-EGT-aMeF(2F)-TSD-4Pal-SI-aMeL-LD-Orn-K((2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-(10-(4-카르복시페녹시)데카노일))AQ-Aib-EFI-(D-Glu)-aMeY-LIEGGK((2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-(10-(4-카르복시페녹시)데카노일))SSGAPPPS-NH₂인 화합물 또는 그의 제약상 허용되는 염.
제23항에 있어서, 화합물이 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-CO-(CH₂)₁₂-CO₂H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-아미노-에톡시)-에톡시]-아세틸)₂-(γ-Glu)-CO-(CH₂)₁₂-CO₂H)SSGAPPPS-NH₂인 화합물 또는 그의 제약상 허용되는 염.
제2형 당뇨병, 비만, NAFLD, 비알콜성 지방간염, 이상지혈증, 및 대사 증후군으로 이루어진 군으로부터 선택된 상태의 치료를 필요로 하는 환자에게 유효량의 제1항 내지 제28항 중 어느 한 항에 따른 화합물 또는 그의 제약상 허용되는 염을 투여하는 것을 포함하는, 제2형 당뇨병, 비만, NAFLD, 비알콜성 지방간염, 이상지혈증, 및 대사 증후군으로 이루어진 군으로부터 선택된 상태를 치료하는 방법.
비만의 치료를 필요로 하는 환자에게 유효량의 제1항 내지 제28항 중 어느 한 항에 따른 화합물 또는 그의 제약상 허용되는 염을 투여하는 것을 포함하는, 비만을 치료하는 방법.
치료적 체중 감소의 제공을 필요로 하는 대상체에게 유효량의 제1항 내지 제28항 중 어느 한 항에 따른 화합물 또는 그의 제약상 허용되는 염을 투여하는 것을 포함하는, 치료적 체중 감소를 제공하는 방법.
제2형 당뇨병의 치료를 필요로 하는 대상체에게 유효량의 제1항 내지 제28항 중 어느 한 항에 따른 화합물 또는 그의 제약상 허용되는 염을 투여하는 것을 포함하는, 제2형 당뇨병을 치료하는 방법.
제1항 내지 제28항 중 어느 한 항에 따른 화합물 또는 그의 제약상 허용되는 염, 및 적어도 1종의 제약상 허용되는 담체, 희석제, 또는 부형제를 포함하는 제약 조성물.
제33항에 있어서, 피하 주사로서 투여되는 제약 조성물.
제33항에 있어서, 경구로 투여되는 제약 조성물.
제1항 내지 제28항 중 어느 한 항에 있어서, 의약으로서 사용하기 위한 화합물 또는 그의 제약상 허용되는 염.
제1항 내지 제28항 중 어느 한 항에 있어서, 제2형 당뇨병, 비만, NAFLD, 비알콜성 지방간염, 이상지혈증, 및 대사 증후군으로 이루어진 군으로부터 선택된 상태를 치료하는데 사용하기 위한 화합물 또는 그의 제약상 허용되는 염.
제1항 내지 제28항 중 어느 한 항에 있어서, 제2형 당뇨병을 치료하는데 사용하기 위한 화합물 또는 그의 제약상 허용되는 염.
제2형 당뇨병, 비만, NAFLD, 비알콜성 지방간염, 이상지혈증, 및 대사 증후군으로 이루어진 군으로부터 선택된 상태를 치료하기 위한 의약의 제조에서의 제1항 내지 제28항 중 어느 한 항에 따른 화합물 또는 그의 제약상 허용되는 염의 용도.
제2형 당뇨병을 치료하기 위한 의약의 제조에서의 제1항 내지 제28항 중 어느 한 항에 따른 화합물 또는 그의 제약상 허용되는 염의 용도.