TWI770781B - Gip/glp1共促效劑化合物 - Google Patents

Gip/glp1共促效劑化合物 Download PDF

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TWI770781B
TWI770781B TW110102332A TW110102332A TWI770781B TW I770781 B TWI770781 B TW I770781B TW 110102332 A TW110102332 A TW 110102332A TW 110102332 A TW110102332 A TW 110102332A TW I770781 B TWI770781 B TW I770781B
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ethoxy
glu
amino
acetyl
aib
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佛南德茲 喬治 亞利西納
羅伯 安德魯 布朗
羅伯 查威克 卡明斯
穆罕默德 艾沙耶德 哈米德 艾沙耶德
安德亞 瑞內 蓋瑟
顯英 賴
屈紅昌
布萊恩 摩根 華森
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Abstract

本發明係關於對人類葡萄糖依賴性促胰島素多肽(glucose-dependent insulinotropic polypeptide；GIP)與升糖素樣肽-1 (glucagon-like peptide-1；GLP-1)受體均具有活性的化合物。本發明亦關於對此等受體中之每一者具有延長之作用時間的化合物。另外，本發明係關於可經口投與的化合物。化合物可用於治療2型糖尿病(type 2 diabetes mellitus；T2DM)。化合物可用於治療肥胖症。

Description

GIP/GLP1共促效劑化合物
本發明係關於對人類葡萄糖依賴性促胰島素多肽(GIP)與升糖素樣肽-1 (GLP-1)受體均具有活性的化合物。本發明亦關於對此等受體中之每一者具有延長之作用時間的化合物。另外，本發明係關於可經口投與的化合物。化合物可用於治療2型糖尿病(「T2DM」)。又，該等化合物可用於治療肥胖症。
在過去幾十年中，糖尿病之盛行率持續上升。T2DM係糖尿病之最常見形式，佔所有糖尿病之約90%。T2DM之特徵在於主要與胰島素抗性相關的高血糖含量。T2DM之當前標準護理包括飲食及運動、用口服藥劑及可注射降糖藥物進行治療，包括基於腸促胰島素之療法，諸如GLP-1受體促效劑。多種GLP-1受體促效劑當前可用於治療T2DM，但當前市售的GLP-1受體促效劑一般因胃腸副作用(諸如噁心及嘔吐)而在劑量上受到限制。皮下注射係可獲得之GLP-1受體促效劑的典型投與途徑。當口服藥劑及基於腸促胰島素之療法不足以治療時，考慮胰島素治療。儘管當今可供使用的治療有進展，但許多T2DM患者未能達到其血糖控制目標。失控的糖尿病引起與患者之發病率及死亡率相關的若干病況。需要一種能夠使更多T2DM患者達到其血糖治療目標的治療。
肥胖症為一種複雜的醫學病症，其使得脂肪組織塊過度積聚。當今肥胖症為一種全球公眾健康問題，其與非所需之健康結果及發病率相關。肥胖症患者之所需治療力求降低過度的體重、改善肥胖症相關的共病，且維持長期體重減輕。可供使用的肥胖症治療尤其不能讓嚴重肥胖症患者滿意。需要替代的治療選項來誘導需要此類治療之患者出現治療性體重減輕。
WO2016/111971描述據稱具有GLP-1及GIP活性的肽。WO2013/164483亦揭示據稱具有GLP-1及GIP活性的化合物。
需要能夠向需要此類治療之大部分患者提供有效葡萄糖控制的T2DM治療。另外需要能夠提供有效葡萄糖控制且具有有利副作用概況的T2D治療。需要替代的治療選項來使得需要此類治療之患者出現治療性體重減輕。對於需要治療重度肥胖症之患者而言，需要替代治療選項。
需要對GIP及GLP-1受體具有促效劑活性且適於經口投與的化合物。為了減少化合物給藥頻率，需要對GIP及GLP-1受體中之每一者之作用時間延長的化合物。需要具有兩種醯化修飾以及具有經工程改造以自單一化合物提供GLP-1及GIP活性之胺基酸序列的化合物。
因此，本發明提供一種式I化合物： X1 X2 EGTX6 TSDX10 X11 X12 X13 LDX16 X17 AQX20 X21 X22 IX24 X25 LIX28 GX30 (SEQ ID NO:4) 其中 X1 選自由Y及R1 Y組成之群； R1 為N端胺基之Ac修飾； X2 為Aib； X6 選自由αMeF及αMeF(2F)組成之群； X10 選自由4Pal、Y、αMeF、αMeF(2F)、αMeL、αMeV、Ac4c、Ac5c、Ac6c、Bip、1Nal、2Nal、OMeY、hTyr、Nle、V、4CPhe、ChG、ChA、Bzt、2FA、4TAA、2TA、3TA及KZ1 組成之群； X11 選自由Ac5c、S、αMeS、Aib、G、Dap及Tle組成之群； X12 選自由I及KZ1 組成之群； X13 選自由αMeL及αMeF組成之群； X16 為Orn； X17 選自由Q、I及KZ1 組成之群； X20 選自由Aib、Orn、4Pal、αMeF、Ac5c及Ac6c組成之群； X21 選自由E、KZ1 、G、Orn及4Pal組成之群； X22 選自由F、2ClPhe、3ClPhe、2FPhe、3FPhe、3,5FPhe、1Nal、2Nal、αMeF(2F)、ChA、Bzt及αMeF組成之群； X24 選自由D-Glu、E、G及KZ1 組成之群； X25 選自由Y、αMeY、αMeF及KZ1 組成之群； X28 選自由E、Orn及KZ1 組成之群； X30 選自由G、Orn、KZ1 及GR2 組成之群； R2 選自由X31 SSG (SEQ ID NO:5)、X31 SSG-R3 (SEQ ID NO:6)、X31 SSGX35 PPPX39 (SEQ ID NO:7)、X31 SSGX35 PPPX39 R3 (SEQ ID NO:8)、X31 SSGX35 PPPX39 X40 (SEQ ID NO:9)、X31 SSGX35 PPPX39 X40 R3 (SEQ ID NO:10)及c端基團之修飾組成之群，其中該修飾為NH2 ； X31 選自由P及KZ1 組成之群； X35 選自由A及Orn組成之群； X39 選自由S及Orn組成之群； X40 為KZ1 ； R3 為C端基團之修飾，其中該修飾為NH2 ； 其中選自由X10 、X12 、X17 、X21 、X24 、X25 、X28 、X30 、X31 及X40 組成之群之兩者且僅兩者為KZ1 ； Z1 選自由R5 及-R4 R5 組成之群；且 R4 為連接子； R5 為脂肪酸；或 其醫藥學上可接受之鹽。
提供一種式I之肽或其醫藥學上可接受之鹽，其中Z1 選自由以下組成之群： -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CO2 H； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基)； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(4-(4-碘苯基)丁醯基)； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(4-(4-三級-丁基苯基)丁醯基)； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )14 -CH3 ； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CH3 ； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 ； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(10-(4-羧基苯氧基)癸醯基)； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )12 -CO2 H； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基)； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )14 -CH3 ； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )10 -CH3 ； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-CO-(CH2 )12 -CO2 H； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-CO-(CH2 )14 -CH3 ； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(εK)-CO-(CH2 )12 -CO2 H； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(εK)-(γ-Glu)-CO-(CH2 )12 -CO2 H； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(εK)-(γ-Glu)-CO-(CH2 )12 -CO2 H； -(εK)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )12 -CO2 H； -(εK)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H； -(εK)-(γ-Glu)-CO-(CH2 )12 -CO2 H； -(εK)-(γ-Glu)-(γ-Glu)-CO-(CH2 )12 -CO2 H； -(γ-Glu)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H； -(εK)-(εK)-(γ-Glu)-CO-(CH2 )12 -CO2 H； -(γ-Glu)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-CO-(CH2 )12 -CO2 H； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-CO-(CH2 )12 -CO2 H； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(7-(4-羧基苯氧基)庚醯基)； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(8-(4-羧基苯氧基)辛醯基)； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(4-(4-三級-丁基苯基)丁醯基)； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(11-(4-羧基苯氧基)十一醯基)； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基)； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-CO-(CH2 )12 -CO2 H； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H； -PEG3-(γ-Glu)-CO-(CH2 )12 -CO2 H； -PEG4-(γ-Glu)-CO-(CH2 )12 -CO2 H； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-CO-(CH2 )10 -CH3 ； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(11-(4-羧基苯氧基)十一醯基； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )14 -CO2 H； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-Ahx-(γ-Glu)-CO-(CH2 )12 -CO2 H； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-Aoc-(γ-Glu)-CO-(CH2 )12 -CO2 H； -Ahx-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )12 -CO2 H； -Aoc-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )12 -CO2 H； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-Ahx-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基)； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基-Aoc-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基)； -Ahx-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基)； -Aoc-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基)； -PEG4-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基)； -PEG3-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基)； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-Aoc-CO-(CH2 )12 -CO2 H； -PEG6-(γ-Glu)-CO-(CH2 )12 -CO2 H； -PEG5-(γ-Glu)-CO-(CH2 )12 -CO2 H； -PEG6-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基)； -PEG5-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基)； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -Trx-(γ-Glu)-CO-(CH2 )12 -CO2 H； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -Trx-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基)； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-Trx-(γ-Glu)-CO-(CH2 )12 -CO2 H； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-Trx-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基)； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)2 -CO-(CH2 )12 -CO2 H； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)2 -(10-(4-羧基苯氧基)癸醯基)； -(γ-Glu)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H； -(γ-Glu)-(2-[2-(2-胺基-乙氧基-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基)； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )12 -CO2 H；及 -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基)。
提供一種式I之肽或其醫藥學上可接受之鹽，其中Z1 選自由以下組成之群： -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CO2 H； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基)； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(4-(4-碘苯基)丁醯基)； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(4-(4-三級-丁基苯基)丁醯基)； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )14 -CH3 ； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CH3 ； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 ； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(10-(4-羧基苯氧基)癸醯基)； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )12 -CO2 H； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基)； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )14 -CH3 ； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )10 -CH3 ； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-CO-(CH2 )12 -CO2 H； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-CO-(CH2 )14 -CH3 ； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(εK)-CO-(CH2 )12 -CO2 H； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(εK)-(γ-Glu)-CO-(CH2 )12 -CO2 H； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(εK)-(γ-Glu)-CO-(CH2 )12 -CO2 H； -(εK)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )12 -CO2 H； -(εK)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H； -(εK)-(γ-Glu)-CO-(CH2 )12 -CO2 H； -(εK)-(γ-Glu)-(γ-Glu)-CO-(CH2 )12 -CO2 H； -(γ-Glu)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H； -(εK)-(εK)-(γ-Glu)-CO-(CH2 )12 -CO2 H； -(γ-Glu)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-CO-(CH2 )12 -CO2 H； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-CO-(CH2 )12 -CO2 H； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(7-(4-羧基苯氧基)庚醯基)； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(8-(4-羧基苯氧基)辛醯基)；及 -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(4-(4-三級-丁基苯基)丁醯基)。
提供一種式I之肽或其醫藥學上可接受之鹽，其中Z1 選自由以下組成之群： -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CO2 H； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基)； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(4-(4-碘苯基)丁醯基)； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(4-(4-三級-丁基苯基)丁醯基)； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )14 -CH3 ； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CH3 ； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 ； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(10-(4-羧基苯氧基)癸醯基)； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )12 -CO2 H； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基)； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )14 -CH3 ； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )10 -CH3 ； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-CO-(CH2 )12 -CO2 H； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-CO-(CH2 )14 -CH3 ； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(εK)-CO-(CH2 )12 -CO2 H； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(εK)-(γ-Glu)-CO-(CH2 )12 -CO2 H； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(εK)-(γ-Glu)-CO-(CH2 )12 -CO2 H； -(εK)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )12 -CO2 H； -(εK)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H； -(εK)-(γ-Glu)-CO-(CH2 )12 -CO2 H； -(εK)-(γ-Glu)-(γ-Glu)-CO-(CH2 )12 -CO2 H； -(γ-Glu)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H； -(εK)-(εK)-(γ-Glu)-CO-(CH2 )12 -CO2 H； -(γ-Glu)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-CO-(CH2 )12 -CO2 H； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-CO-(CH2 )12 -CO2 H； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(7-(4-羧基苯氧基)庚醯基)； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(8-(4-羧基苯氧基)辛醯基)；及 -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(4-(4-三級-丁基苯基)丁醯基)。
提供一種式I化合物或其醫藥學上可接受之鹽，其中R5 選自由以下組成之群： -CO-(CH2 )12 -CO2 H、-CO-(CH2 )10 -CO2 H、-(10-(4-羧基苯氧基)癸醯基)、-(4-(4-碘苯基)丁醯基)、-(4-(4-三級-丁基苯基)丁醯基)、-CO-(CH2 )14 -CH3 、-CO-(CH2 )12 -CH3 、-CO-(CH2 )10 -CH3 、-(7-(4-羧基苯氧基)庚醯基)、-(8-(4-羧基苯氧基)辛醯基)、(11-(4-羧基苯氧基)十一醯基)及CO-(CH2 )14 -CO2 H。
提供一種式I化合物或其醫藥學上可接受之鹽，其中R5 選自由以下組成之群： -CO-(CH2 )12 -CO2 H、-CO-(CH2 )10 -CO2 H、-(10-(4-羧基苯氧基)癸醯基)、-(4-(4-碘苯基)丁醯基)、-(4-(4-三級-丁基苯基)丁醯基)、-CO-(CH2 )14 -CH3 、-CO-(CH2 )12 -CH3 、-CO-(CH2 )10 -CH3 、-(7-(4-羧基苯氧基)庚醯基)及-(8-(4-羧基苯氧基)辛醯基)。
提供一種式I化合物或其醫藥學上可接受之鹽，其中R4 選自由以下組成之群： -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)2 )-； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(εK)-； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(εK)-(γ-Glu)-； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(εK)-(γ-Glu)-； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-Trx-(γ-Glu)-； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -Trx-(γ-Glu)-； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-Aoc-； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-Aoc-(γ-Glu)-； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-Ahx-(γ-Glu)-； -PEG3-(γ-Glu)-； -PEG4-(γ-Glu)-； -PEG5-(γ-Glu)-； -PEG6-(γ-Glu)-； -Ahx-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-； -Aoc-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-； -(εK)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-； -(εK)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-； -(εK)-(γ-Glu)-； -(εK)-(γ-Glu)-(γ-Glu)-； -(γ-Glu)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -； -(εK)-(εK)-(γ-Glu)-； -(γ-Glu)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-； -(γ-Glu)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -；及 (2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-。
提供一種式I化合物或其醫藥學上可接受之鹽，其中R4 選自由以下組成之群： -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(εK)-； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(εK)-(γ-Glu)-； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(εK)-(γ-Glu)-； -(εK)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-； -(εK)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-； -(εK)-(γ-Glu)-； -(εK)-(γ-Glu)-(γ-Glu)-； -(γ-Glu)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -； -(εK)-(εK)-(γ-Glu)-； -(γ-Glu)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-；及 -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(2-[2-(2-胺基-乙氧基-乙氧基]-乙醯基)-。
提供一種式I化合物或其醫藥學上可接受之鹽，其中X17 及X31 各自為KZ1 。提供一種式I化合物或其醫藥學上可接受之鹽，其中X17 及X24 各自為KZ1 。提供一種式I化合物或其醫藥學上可接受之鹽，其中X17 及X21 各自為KZ1 。提供一種式I化合物或其醫藥學上可接受之鹽，其中X17 及X28 各自為KZ1 。提供一種式I化合物或其醫藥學上可接受之鹽，其中X17 及X40 各自為KZ1 。提供一種式I化合物或其醫藥學上可接受之鹽，其中X21 及X40 各自為KZ1 。提供一種式I化合物或其醫藥學上可接受之鹽，其中X21 及X28 各自為KZ1 。提供一種式I化合物或其醫藥學上可接受之鹽，其中X24 及X28 各自為KZ1 。
提供一種式I化合物或其醫藥學上可接受之鹽，其中X6 為αMeF(2F)；X10 選自由4Pal、Y及KZ1 組成之群；X11 選自由S、αMeS及Aib組成之群；X12 為I；X13 為αMeL；X16 為Orn；X17 選自由KI及KZ1 組成之群；X20 為Aib；X21 選自由KZ1 及E組成之群；X22 選自由F及αMeF組成之群；X24 選自由D-Glu及KZ1 組成之群；X25 為αMeY；X28 選自由E及KZ1 組成之群；X30 選自由G及GR2 組成之群；R2 選自由X31 SSGX35 PPPX39 (SEQ ID NO:7)、X31 SSGX35 PPPX39 R3 (SEQ ID NO:8)及X31 SSGX35 PPPX39 X40 (SEQ ID NO:9)及C端基團之修飾組成之群，其中該修飾為NH2 ；X31 選自由P及KZ1 組成之群；X35 選自由A及Orn組成之群；X39 選自由S、Orn組成之群；X40 選自由KZ1 組成之群；R3 為C端基團之修飾，其中該修飾為NH2 ；其中選自由X10 、X17 、X21 、X24 、X28 、X31 及X40 組成之群之兩者且僅兩者為KZ1 ；Z1 為-R4 R5 ；R4 為連接子；且R5 為脂肪酸；或其醫藥學上可接受之鹽。
提供一種式I化合物或其醫藥學上可接受之鹽，其中該化合物選自由以下組成之群： Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 ； Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))SSGAPPPS-NH2 ； Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(4-(4-碘苯基)丁醯基))AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(4-(4-碘苯基)丁醯基))SSGAPPPS-NH2 ； Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(4-(4-三級-丁基苯基)丁醯基))AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(4-(4-三級-丁基苯基)丁醯基))SSGAPPPS-NH2 ；及 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )SSGAPPPS-NH2 。
在一實施例中，R4 連接子為選自由εK及γ-Glu組成之群的一至兩個胺基酸。在一實施例中，R4 連接子包含一至三個(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)部分。在一實施例中，R5 脂肪酸部分經由離胺酸與R5 脂肪酸之間的R4 連接子與離胺酸結合。
在一實施例中，為式I化合物或其醫藥學上可接受之鹽，其中R4 連接子包含零至四個胺基酸；及零至三個(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)部分。在一實施例中，R4 連接子包含一至三個各自獨立地選自由εK及γ-Glu組成之群的胺基酸。在一實施例中，為式I化合物或其醫藥學上可接受之鹽，其中R4 連接子包含1至2個各自獨立地選自由εK及γ-Glu組成之群的胺基酸。在一實施例中，為式I化合物或其醫藥學上可接受之鹽，其包含兩個各自經由R4 連接子與肽之不同離胺酸結合的Z1 脂肪酸部分，其中R4 連接子包含零至2個γ-Glu胺基酸殘基。在一實施例中，為式I化合物或其醫藥學上可接受之鹽，其包含兩個各自經由R4 連接子與肽之不同離胺酸結合的Z1 脂肪酸部分，其中R4 包含一至三個胺基酸及一至三個(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)部分。在一實施例中，為式I化合物或其醫藥學上可接受之鹽，其包含兩個各自經由R4 連接子與肽之不同離胺酸結合的相同Z1 脂肪酸部分，其中R4 包含一至三個各自獨立地選自由εK及ɤ-Glu組成之群的胺基酸；及一至三個連接至胺基酸之(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)部分。在一實施例中，為式I化合物或其醫藥學上可接受之鹽，其包含兩個各自經由R4 連接子與肽之不同離胺酸結合的相同Z1 脂肪酸部分，其中R4 包含至多三個連接至一或兩個(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)部分之各自獨立地選自由γ-Glu及εK組成之群的胺基酸。
在一實施例中，為式I化合物或其醫藥學上可接受之鹽，其包含兩個相同Z1 脂肪酸部分，該等相同Z1 脂肪酸部分各自經由R4 連接子結合，其中R4 連接子具有下式： -(εK)a1-(γ-Glu)a2-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)a3-(εK)b1-(γ-Glu)b2-； 其中a1選自由0、1及2組成之群；a2選自由0、1及2組成之群；a3選自由0、1、2及3組成之群；b1為0或1；且b2為0或1。在一實施例中，為式I化合物或其醫藥學上可接受之鹽，其包含兩個各自經由R4 連接子結合之相同Z1 脂肪酸部分，其中Z具有下式： -(εK)a1-(γ-Glu)a2-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)a3-(εK)b1-(γ-Glu)b2-CO-(CH2 )q-CO2 H，其中a1選自由0、1及2組成之群；a2選自由0、1及2組成之群；a3選自由0、1、2及3組成之群；b1為0或1；b2為0或1；且q選自由10、12、14及16組成之群。
在一實施例中，a1為1，a2為0，a3為2，b1為0，b2為1，且q為12；且結構為： -(εK)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12-CO2 H。
在一實施例中，為式I化合物或其醫藥學上可接受之鹽，其包含兩個各自經由R4 連接子結合之相同Z1 脂肪酸部分，其中R4 連接子及R5 脂肪酸組分具有下式：
Figure 02_image001
其中q2選自由7、8、10、11及12組成之群。
在一實施例中，為式I化合物或其醫藥學上可接受之鹽，其包含兩個各自經由R4 連接子結合之相同Z1 脂肪酸部分，其中R5 脂肪酸選自由-(7-(4-羧基苯氧基)庚醯基)及-(8-(4-羧基苯氧基)辛醯基)組成之群。在一實施例中，為式I化合物或其醫藥學上可接受之鹽，其包含兩個各自經由R4 連接子結合之相同Z1 脂肪酸部分，其中R5 脂肪酸選自由-(10-(4-羧基苯氧基)癸醯基)、-(4-(4-碘苯基)丁醯基)及-(4-(4-三級-丁基苯基)丁醯基)組成之群。
在一實施例中，為式I化合物或其醫藥學上可接受之鹽，其包含兩個各自經由R4 連接子結合之相同Z1 脂肪酸部分，其中R5 脂肪酸選自由-CO-(CH2 )14 -CH3 、-CO-(CH2 )12 -CH3 及-CO-(CH2 )10 -CH3 組成之群。
在一實施例中，為式I化合物或其醫藥學上可接受之鹽，其包含兩個各自經由R4 連接子結合之相同Z1 脂肪酸部分，其中R5 脂肪酸選自由-CO-(CH2 )12 -CO2 H及-CO-(CH2 )10 -CO2 H組成之群。在一實施例中，為式I化合物或其醫藥學上可接受之鹽，其包含兩個各自經由R4 連接子結合之相同Z1 脂肪酸部分，其中R5 脂肪酸選自由-CO-(CH2 )10 -CH3 及-CO-(CH2 )12 -CH3 組成之群。
在一實施例中，R5 脂肪酸選自由-CO-(CH2 )12 -CO2 H、-CO-(CH2 )10 -CO2 H、-(10-(4-羧基苯氧基)癸醯基)、-(4-(4-碘苯基)丁醯基)、-(4-(4-三級-丁基苯基)丁醯基)、-CO-(CH2 )14 -CH3 、-CO-(CH2 )12 -CH3 、-CO-(CH2 )10 -CH3 、-(7-(4-羧基苯氧基)庚醯基)及-(8-(4-羧基苯氧基)辛醯基)組成之群。
一實施例提供一種治療選自由以下組成之群之病況的方法：T2DM、肥胖症、非酒精性脂肪肝病(NAFLD)、非酒精性脂肝炎(NASH)、血脂異常及代謝症候群，該方法包含向有需要之個體投與有效量的式I化合物或其醫藥學上可接受之鹽。一實施例提供一種用於提供治療性體重減輕之方法，該方法包含向有需要之個體投與有效量的式I化合物或其醫藥學上可接受之鹽。在一個實施例中，病況為NAFLD。在一個實施例中，病況為NASH。
一實施例提供一種式I化合物或其醫藥學上可接受之鹽，其用於療法中。一實施例提供一種式I化合物或其醫藥學上可接受之鹽，其用於在療法中治療選自由以下組成之群的病況：T2DM、肥胖症、NAFLD、NASH、血脂異常及代謝症候群。在一實施例中，病況為T2DM。在一實施例中，病況為肥胖症。在一實施例中，病況為NAFLD。在一實施例中，病況為NASH。在一實施例中，病況為代謝症候群。在一實施例中提供式I化合物或其醫藥學上可接受之鹽之用途，其用於製造用於治療2型糖尿病之藥劑。在一實施例中，為式I化合物或其醫藥學上可接受之鹽，其用作藥劑。在一實施例中，為式I化合物或其醫藥學上可接受之鹽，其用於治療選自由以下組成之群的病況：2型糖尿病、肥胖症、NAFLD、非酒精性脂肝炎、血脂異常及代謝症候群。
式I化合物或其醫藥學上可接受之鹽可用於治療多種症狀或病症。舉例而言，某些實施例提供一種用於治療患者之T2DM之方法，該方法包含向需要此類治療之個體投與有效量的式I化合物或其醫藥學上可接受之鹽。在一實施例中，為一種用於治療患者之肥胖症的方法，該方法包含向需要此類治療之個體投與有效量的式I化合物或其醫藥學上可接受之鹽。在一實施例中，方法為誘導個體之非治療性體重減輕，該方法包含向需要此類治療之個體投與有效量的式I化合物或其醫藥學上可接受之鹽。
在某些實施例中，本發明提供一種用於治療患者之代謝症候群的方法，其包含向需要此類治療之個體投與有效量的式I化合物或其醫藥學上可接受之鹽。在一實施例中，該方法為治療NASH，其包含向需要此類治療之個體投與有效量的式I化合物或其醫藥學上可接受之鹽。
本文亦提供與一或多種藥劑同時、分開及依序組合使用以治療選自由T2DM、肥胖症、NAFLD、NASH、血脂異常及代謝症候群組成之群之病況的本發明化合物，該或該等藥劑選自二甲雙胍、噻唑啶二酮、磺醯脲、二肽基肽酶4抑制劑、鈉-葡萄糖共轉運體、SGLT-2抑制劑、生長分化因子15調節劑(「GDF15」)、肽酪胺酸酪胺酸調節劑(「PYY」)、經修飾之胰島素、澱粉素、雙重澱粉素降鈣素受體促效劑及調酸素促效劑(「OXM」)。在一實施例中，本發明化合物與一或多種藥劑以固定劑量組合提供，該或該等藥劑選自二甲雙胍、噻唑啶二酮、磺醯脲、二肽基肽酶4抑制劑、鈉-葡萄糖共轉運體、SGLT-2抑制劑、GDF15、PYY、經修飾之胰島素、澱粉素、雙重澱粉素降鈣素受體促效劑及OXM。在一實施例中，為本發明化合物與一或多種藥劑同時、分開及依序組合使用以治療選自由T2DM及肥胖症組成之群的病況，該或該等藥劑選自二甲雙胍、噻唑啶二酮、磺醯脲、二肽基肽酶4抑制劑、鈉-葡萄糖共轉運體、SGLT-2抑制劑、GDF15、PYY、經修飾之胰島素、澱粉素、雙重澱粉素降鈣素受體促效劑及OXM。在一實施例中，為本發明化合物與一或多種藥劑同時、分開及依序組合使用以治療選自由T2DM及肥胖症組成之群的病況，該或該等藥劑選自二甲雙胍、噻唑啶二酮、磺醯脲、二肽基肽酶4抑制劑、鈉-葡萄糖共轉運體及SGLT-2抑制劑。
在其他實施例中，該等化合物或其醫藥學上可接受之鹽可用於改善有需要之個體之骨骼強度。本發明化合物或其醫藥學上可接受之鹽可用於治療其他病症，諸如帕金森氏病(Parkinson's disease)或阿茲海默氏病(Alzheimer's disease)。對GIP、GLP-1及/或升糖素受體中之一或多者具有活性的腸促胰島素及腸促胰島素類似物已描述為對多種其他疾病或病況具有潛在的治療價值，包括例如肥胖症、NAFLD及NASH、血脂異常、代謝症候群、骨骼相關病症、阿茲海默氏病及帕金森氏病。參見例如, Jall S., 等人,Monomeric GLP-1/GIP/glucagon triagonism corrects obesity, hepatosteatosis, and dyslipidemia in female mice , MOL. METAB. 6(5):440-446 (2017年3月)；Carbone L.J., 等人,Incretin -based therapies for the treatment of non-alcoholic fatty liver disease: A systematic review and meta-analysis . J.GASTROENTEROL. HEPATOL., 31(1):23-31 (2016年1月)；B. Finan, 等人,Reappraisal of GIP Pharmacology for Metabolic Diseases . TRENDS MOL. MED., 22(5):359-76 (2016年5月)；Choi, I.Y., 等人,Potent body weight loss and efficacy in a NASH animal model by a novel long-acting GLP-1/Glucagon/GIP triple-agonist (HM15211) , ADA 2017 Poster 1139-P；Ding, K.H.,Impact of glucose-dependent insulinotropic peptide on age-induced bone loss , J. BONE MINER. RES., 23(4):536-43 (2008)；Tai, J. 等人,Neuroprotective effects of a triple GLP-1/GIP/glucagon receptor agonist in the APP/PS1 transgenic mouse model of Alzheimer ' s disease , BRAIN RES. 1678, 64-74 (2018)；T.D. Müller 等人,The New Biology and Pharmacology of Glucagon , PHYSIOL. REV. 97: 721-766 (2017)；Finan, B. 等人,Unimolecular Dual Incretins Maximize Metabolic Benefits in Rodents, Monkeys, and Humans , SCI. TRANSL. MED., 5:209 (2013年10月)；Hölscher C,Insulin, incretins and other growth factors as potential novel treatments for Alzheimer's and Parkinson's diseases . BIOCHEM. SOC. TRANS. 42(2):593-0 (2014年4月)。
另一實施例提供本發明化合物或其醫藥學上可接受之鹽的用途，其用於製造用於治療選自由以下組成之群之病況的藥劑：T2DM、肥胖症、NAFLD、NASH、血脂異常及代謝症候群。在一實施例中，藥劑用於治療T2DM。在一實施例中，藥劑用於治療肥胖症。在一實施例中，藥劑用於治療NAFLD。在一實施例中，藥劑用於治療NASH。
另一實施例提供一種醫藥組合物，其包含式I化合物或其醫藥學上可接受之鹽，及選自由載劑、稀釋劑及賦形劑組成之群之至少一者。
本專利申請案根據35 U.S.C. §119(e)主張在2020年1月23日申請之美國臨時申請案第62/964,932號的權利；其揭示內容以引用之方式併入本文中。
如本文所用，術語「治療(treating)」或「以治療(to treat)」包括抑制、減緩、停止或逆轉症狀、病況或病症之進展或嚴重程度。
本文所提供之某些化合物在寬劑量範圍內一般為有效的。舉例而言，每週一次非經腸給藥之劑量可以在每人每週0.05 mg至約30 mg範圍內。本文所提供之化合物為經口可用的且可使用口服調配物技術進行給藥。口服調配物可經調配用於定期給藥，諸如每日一次。
本發明化合物包括對相應GLP-1及GIP受體具有親和力的新穎胺基酸序列，其對此等受體中之每一者具有所需效能。GLP-1為36個胺基酸之肽，其主要生物學活性片段係作為30個胺基酸之C端醯胺化肽(GLP-17-36 )(SEQ ID NO:2)產生。
GIP為42個胺基酸之肽(SEQ ID NO:1)，如同GLP-1，其亦稱為腸促胰島素，且藉由在葡萄糖存在下刺激胰臟β細胞分泌胰島素而在葡萄糖穩恆方面起生理學作用。
化合物為GIP及GLP-1受體中之每一者提供所需效能。在一實施例中，化合物適於經口投與。在一實施例中，化合物對GIP及GLP受體具有所需的經延時之作用。
如本文所用，「連接子」意謂使脂肪酸結合至肽之離胺酸的基團。如本文所用，「脂肪酸」意謂具有羧基的烴。如本文所用，「Ac」意謂乙醯基修飾。在一實施例中，脂肪酸為白蛋白結合基團。如本文所用，術語「胺基酸」意謂天然存在之胺基酸與非天然胺基酸兩者。胺基酸典型地使用標準單字母碼(例如L=白胺酸)以及天然胺基酸之α-甲基取代殘基(例如α-甲基白胺酸，或αMeL及α-甲基離胺酸，或αMeK)及某些其他非天然胺基酸(諸如α胺基異丁酸，或「Aib」、「4Pal」、「Orn」及其類似物)描述。非天然胺基酸及其他縮寫之結構呈現如下：
Figure 02_image003
Figure 02_image005
Figure 02_image007
Figure 02_image009
如本文所用，「Orn」意謂鳥胺酸。如本文所用，「4Pal」意謂3-(4-吡啶基)-L-丙胺酸。如本文所用，「αMeF(2F)」意謂α-甲基2-F-苯丙胺酸、α-甲基-F(2F)及α-甲基-Phe(2F)。如本文所用，「αMeY」意謂α甲基酪胺酸、α甲基-Tyr及α甲基-Y。如本文所用，「αMeL」意謂α甲基白胺酸、α甲基-L及α甲基-Leu。如本文所用，「e」及「D-Glu」意謂D-麩胺酸。如本文所用，「αMeF」」意謂α-甲基-F及α-甲基-Phe。如本文所用，「αMeS」意謂α-甲基-絲胺酸、α-甲基-S及α-甲基-Ser。如本文所用，「AEEA」意謂(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)；「AEEA2」意謂2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 ；及「AEEA3」意謂(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 。
如本文所用，「Ahx」為6-胺基己醯基-；「Aoc」為8-胺基辛醯基-；「PEG3」為[3-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙氧基)-丙醯基]-；「PEG4」為(3-[2-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙氧基)-乙氧基]-丙醯基)-；「PEG5」為[3-(2-[2-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙氧基)-乙氧基]-乙氧基)-丙醯基]-；及「PEG6」為(3-[2-(2-[2-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙氧基)-乙氧基]-乙氧基)-乙氧基]-丙醯基)-。
如以下實例之化學結構所示，在一實施例中，上文所描述之連接子-脂肪酸部分(-R5 R4 )與離胺酸側鏈之ε-胺基連接。
當本文中參考GIP或GLP-1受體中之一或多者使用時，術語「活性」、「活化」、「正活化」及其類似物係指化合物或其醫藥學上可接受之鹽結合至受體且誘導受體反應的能力，如使用此項技術中已知的分析(諸如下文所描述的活體外分析)所量測。
本發明之化合物或其醫藥學上可接受之鹽對GIP及GLP-1受體中之每一者的親和力可使用此項技術中已知的量測受體結合水準之技術量測，該等技術包括例如以下實例中所描述之技術，且親和力通常表示為Ki值。本發明之化合物對每一種受體之活性亦可使用此項技術中已知之技術量測，包括例如下文所描述之活體外活性分析，且活性通常表示為EC50 值，其為劑量反應曲線中引起最大刺激一半之化合物濃度。
在一實施例中，式I化合物之醫藥組合物適於藉由非經腸途徑(例如，皮下、靜脈內、腹膜內、肌肉內或經皮)投與。在一實施例中，式I化合物之醫藥組合物適合於經口投與(例如錠劑、膠囊)。一些醫藥組合物及其製備方法在此項技術中已熟知。(參見例如Remington: The Science and Practice of Pharmacy (編輯D.B. Troy, 第21版, Lippincott, Williams & Wilkins, 2006)。
本文所描述之化合物可與多種無機及有機酸/鹼反應以形成醫藥學上可接受之酸/鹼加成鹽。醫藥學上可接受之鹽及製備其之常見方法在此項技術中為人所熟知。(參見例如P. Stahl, 等人, Handbook of Pharmaceutical Salts: Properties, Selection and Use, 第二修訂版 (Wiley-VCH, 2011))。本發明之醫藥學上可接受之鹽包括(但不限於)鈉鹽、三氟乙酸鹽、鹽酸鹽、銨鹽及乙酸鹽。在一實施例中，醫藥學上可接受之鹽選自由鈉鹽、鹽酸鹽及乙酸鹽組成之群。
本發明亦涵蓋用於合成本發明化合物或其醫藥學上可接受之鹽的新穎中間物及方法。本發明之中間物及化合物可藉由此項技術中已知的多種程序製備。特定言之，以下實例描述使用化學合成之方法。所描述之途徑中之每一者的特定合成步驟可以不同方式組合以製備本發明化合物。試劑及起始材料為一般技術者容易獲得的。
當在本文中使用時，術語「有效量」係指本文所提供之化合物或其醫藥學上可接受之鹽的量或劑量，其在單劑量或多劑量投與至患者後，對正在診斷或治療之患者提供期望之效果。有效量可由熟習此項技術者使用已知技術且藉由觀測在類似情形下所獲得的結果來測定。在測定個體之有效量時，考慮多種因素，包括(但不限於)：哺乳動物之物種；其體型、年齡及一般健康狀況；所涉入之具體疾病或病症；疾病或病症之涉入程度或嚴重程度；個別患者之反應；所投與之特定化合物；投藥模式；所投與製劑之生物可用性特徵；所選擇之劑量方案；伴隨療法之使用；及其他相關情形。
當在本文中使用時，術語「有需要之個體」係指哺乳動物，較佳為人類，其患有需要治療或療法之疾病或病況，包括例如前述段落中所列之彼等疾病或病況。如本文所用，「EDTA」意謂乙二胺四乙酸。如本文所用，「DMSO」意謂二甲亞碸。如本文所用，「CPM」意謂每分鐘之計數。如本文所用，「IBMX」意謂3-異丁基-1-甲基黃嘌呤。如本文所用，「LC/MS」意謂液相層析/質譜。如本文所用，「HTRF」意謂均質時間解析螢光。如本文所用，「BSA」意謂牛血清白蛋白。
本發明進一步藉由以下實例說明，該等實例不應理解為具限制性。
肽合成 實例 1 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2- 胺基 - 乙氧基 )- 乙氧基 ]- 乙醯基 )2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2- 胺基 - 乙氧基 )- 乙氧基 ]- 乙醯基 )2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 (SEQ ID NO:11).
除殘基Aib2、αMeF(2F)6、4Pal10、αMeL13、Orn16、K17、Aib20、D-Glu24、αMeY25、K31及Ser39之外(其中此等胺基酸殘基之結構已擴增)，下文使用標準單字母胺基酸碼描繪SEQ ID NO:11之結構：
Figure 02_image011
實例1之肽主鏈係在Symphony多重肽合成儀(Gyros Protein Technologies. Tucson, AZ)上利用茀基甲氧基羰基(Fmoc)/三級丁基(t-Bu)化學方法進行合成。
樹脂係以取代度為0.35 mmol/g之1% DVB交聯聚苯乙烯(Fmoc-Rink-MBHA低負載樹脂，100至200目，EMD Millipore)組成。使用標準側鏈保護基。Fmoc-Lys(Mtt)-OH用於位置17及31處之離胺酸殘基，及Boc-Tyr(tBu)-OH用於位置1處之酪胺酸殘基。在各偶合步驟(2×7分鐘)之前，使用含20%哌啶之DMF移除Fmoc基團。使用相等莫耳比之Fmoc胺基酸(0.3 mM於DMF中)、二異丙基碳化二亞胺(0.9 mM於DCM中)及Oxyma(0.9 mM於DMF中)以超過理論肽負載量9倍之莫耳濃度執行所有標準胺基酸偶合1小時。例外之處係當與Cα-甲基化胺基酸偶合時，偶合進行3小時。在完成肽主鏈之合成之後，將樹脂用DCM充分洗滌以移除殘餘DMF。使用含30%六氟異丙醇(Oakwood Chemicals)之DCM選擇性地自肽樹脂移除位置17及31處之離胺酸殘基上的Mtt保護基(3×1小時處理)，且將樹脂用DCM及DMF充分洗滌。
藉由遵循上述用於標準偶合及去除保護基反應之程序逐步地偶合2-[2-(2-Fmoc-胺基-乙氧基)-乙氧基]-乙酸(Fmoc-AEEA-OH, ChemPep, Inc.)及Fmoc-麩胺酸α-三級丁酯(Fmoc-Glu-OtBu, Ark Pharm, Inc.)實現連接子部分之後續連接。在移除最終Fmoc保護基後，使用4倍過量之脂肪酸、二異丙基碳化二亞胺及Oxyma(1:1:1 mol/mol/mol)於1:1 DCM/DMF中將單-OtBu-十四烷二酸(中國上海WuXi AppTec)偶合隔夜。在合成完成後，將肽樹脂用DCM洗滌且接著充分真空乾燥。
乾燥樹脂在室溫下用10 mL裂解混合物(三氟乙酸:水:三異丙基矽烷，95:2.5:2.5體積比)處理2小時。濾出樹脂，各用2 mL純淨TFA洗滌兩次，且合併的濾液用5倍體積過量的冷乙醚(-20℃)處理以使粗肽沈澱。肽/乙醚懸浮液接著以3500 rpm離心2分鐘以形成固體離心塊，傾析上清液，且固體離心塊用乙醚再濕磨兩次且真空乾燥。將粗肽溶解於20 ml之20%乙腈/20%乙酸/60%水中且藉由在線性梯度為100%乙腈及0.1%TFA/水緩衝系統(在60分鐘內，35至55%乙腈)的SymmetryPrep 7 µm C18製備型管柱(19×300 mm，Waters)上之RP-HPLC來純化。使用分析型RP-HPLC評定肽之純度且合併準則(pooling criteria)為＞95%。發現實例1之主要池純度為96.0%。隨後凍乾最終主要產物池，產生凍乾肽TFA鹽。分子量藉由LC-MS測定(觀察值：M+3=1853.9；計算值 M+3=1854.1)。
實例 2 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2- 胺基 - 乙氧基 )- 乙氧基 ]- 乙醯基 )2 -(γ-Glu)-(10-(4- 羧基苯氧基 ) 癸醯基 ))AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2- 胺基 - 乙氧基 )- 乙氧基 ]- 乙醯基 )2 -(γ-Glu)-(10-(4- 羧基苯氧基 ) 癸醯基 ))SSGAPPPS-NH2 (SEQ ID NO:12)
除殘基Aib2、αMeF(2F)6、4Pal10、αMeL13、Orn16、K17、Aib20、D-Glu24、αMeY25、K31及Ser39之外(其中此等胺基酸殘基之結構已擴增)，下文使用標準單字母胺基酸碼描繪SEQ ID NO:12之結構：
Figure 02_image013
除在最終偶合步驟中使用4-(9-羧基-壬氧基)苯甲酸三級丁酯(中國上海WuXi AppTec)以外，根據SEQ ID NO:12之化合物實質上如實例1之程序所述來製備。分子量藉由LC-MS測定(觀察值：M+3=1887.1；計算值M+3=1887.4)。
實例 3 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2- 胺基 - 乙氧基 )- 乙氧基 ]- 乙醯基 )2 -(γ-Glu)-(4-(4- 碘苯基 ) 丁醯基 ))AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2- 胺基 - 乙氧基 )- 乙氧基 ]- 乙醯基 )2 -(γ-Glu)-(4-(4- 碘苯基 ) 丁醯基 ))SSGAPPPS-NH2 (SEQ ID NO:13)
除殘基Aib2、αMeF(2F)6、4Pal10、αMeL13、Orn16、K17、Aib20、D-Glu24、αMeY25、K31及Ser39之外(其中此等胺基酸殘基之結構已擴增)，下文使用標準單字母胺基酸碼描繪SEQ ID NO:13之結構：
Figure 02_image015
除在最終偶合步驟中使用4-(4-碘苯基)丁酸(中國上海WuXi AppTec)以外，根據SEQ ID NO:13之化合物實質上如實例1之程序所述來製備。分子量藉由LC-MS測定(觀察值：M+3=1875.1；計算值M+3=1875.2)。
實例 4 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2- 胺基 - 乙氧基 )- 乙氧基 ]- 乙醯基 )2 -(γ-Glu)-(4-(4- 三級 - 丁基苯基 ) 丁醯基 ))AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2- 胺基 - 乙氧基 )- 乙氧基 ]- 乙醯基 )2 -(γ-Glu)-(4-(4- 三級 - 丁基苯基 ) 丁醯基 ))SSGAPPPS-NH2 (SEQ ID NO:14)
除殘基Aib2、αMeF(2F)6、4Pal10、αMeL13、Orn16、K17、Aib20、D-Glu24、αMeY25、K31及Ser39之外(其中此等胺基酸殘基之結構已擴增)，下文使用標準單字母胺基酸碼描繪SEQ ID NO:14之結構：
Figure 02_image017
除在最終偶合步驟中使用4-(4-三級-丁基苯基)丁酸(中國上海WuXi AppTec)以外，根據SEQ ID NO:14之化合物實質上如實例1之程序所述來製備。分子量藉由LC-MS測定(觀察值：M+3=1828.3；計算值M+3=1828.7)。
實例 5 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2- 胺基 - 乙氧基 )- 乙氧基 ]- 乙醯基 )2 -(γ-Glu)-CO-(CH2 )10 -CH3 )AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2- 胺基 - 乙氧基 )- 乙氧基 ]- 乙醯基 )2 -(γ-Glu)-CO-(CH2 )10 -CH3 )SSGAPPPS-NH2 (SEQ ID NO:15).
除殘基Aib2、αMeF(2F)6、4Pal10、αMeL13、Orn16、K17、Aib20、D-Glu24、αMeY25、K31及Ser39之外(其中此等胺基酸殘基之結構已擴增)，下文使用標準單字母胺基酸碼描繪SEQ ID NO:15之結構：
Figure 02_image019
除在最終偶合步驟中使用月桂酸(Sigma Aldrich)以外，根據SEQ ID NO:15之化合物實質上如實例1之程序所述來製備。分子量藉由LC-MS測定(觀察值：M+3=1815.1；計算值M+3=1815.4)。
實例 6 至實例 211 根據實例6 (SEQ ID NO:16)至實例494 (SEQ ID NO:504)之化合物實質上如實例1之程序所述來製備。
實例 名稱 SEQ ID NO MW計算值 (g/mol)
6 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CO2 H)SSGAPPPS-NH2 16 5503.09
7 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )14 -CH3 )AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )14 -CH3 )SSGAPPPS-NH2 17 5555.33
8 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CH3 )AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CH3 )SSGAPPPS-NH2 18 5499.23
9 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 19 5300.97
10 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(10-(4-羧基苯氧基)癸醯基))AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(10-(4-羧基苯氧基)癸醯基))SSGAPPPS-NH2 20 5401
11 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 21 5268.88
12 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))SSGAPPPS-NH2 22 5368.91
13 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )14 -CH3 )AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )14 -CH3 )SSGAPPPS-NH2 23 5265.02
14 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )10 -CH3 )AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )10 -CH3 )SSGAPPPS-NH2 24 5152.81
15 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)FI-(D-Glu)-αMeY-LIEGGPSSGAPPPS-NH2 25 5527.2
16 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeY-LIEGGPSSGAPPPS-NH2 26 5527.2
17 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 27 5527.2
18 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)PSSGAPPPS-NH2 28 5599.26
19 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGPSSGAPPPSK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-NH2 29 5656.31
20 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-IAQ-Aib-EFI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)GGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 30 5543.24
21 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )14 -CH3 )AQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )14 -CH3 )FI-(D-Glu)-αMeY-LIEGGPSSGAPPPS-NH2 31 5583.3
22 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )14 -CH3 )AQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )14 -CH3 )-αMeY-LIEGGPSSGAPPPS-NH2 32 5583.3
23 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )14 -CH3 )AQ-Aib-EFI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )14 -CH3 )GGPSSGAPPPS-NH2 33 5523.34
24 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )14 -CH3 )AQ-Aib-EFI-(D-Glu)-αMeY-LIEGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )14 -CH3 )PSSGAPPPS-NH2 34 5595.4
25 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )14 -CH3 )AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGPSSGAPPPSK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )14 -CH3 )-NH2 35 5652.45
26 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-IAQ-Aib-EFI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )14 -CH3 )GGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )14 -CH3 )SSGAPPPS-NH2 36 5539.38
27 Y-Aib-EGT-αMeF(2F)-TSDK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGPSSGAPPPS-NH2 37 5508.15
28 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGPSSGAPPPS-NH2 38 5543.15
29 Y-Aib-EGT-αMeF(2F)-TSDK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )14 -CH3 )SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )14 -CH3 )AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGPSSGAPPPS-NH2 39 5504.29
30 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 40 5849.51
31 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-CO-(CH2 )14 -CH3 )AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-CO-(CH2 )14 -CH3 )SSGAPPPS-NH2 41 5845.65
32 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )14 -CH3 )AQ-Aib-EFI-(D-Glu)K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )14 -CH3 )LIEGGPSSGAPPPS-NH2 42 5475.25
33 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(εK)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(εK)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 43 5557.31
34 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(εK)-(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(εK)-(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 44 5815.54
35 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(εK)-(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-acetyl)-(εK)-(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 45 5525.23
36 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((εK)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((εK)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 46 5525.23
37 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((εK)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((εK)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 47 5815.54
38 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((εK)-(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((εK)-(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 48 5234.91
39 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((εK)-(γ-Glu)-(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((εK)-(γ-Glu)-(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 49 5493.14
40 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((εK)-(εK)-(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((εK)-(εK)-(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 50 5491.26
41 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((γ-Glu)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((γ-Glu)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 51 5559.19
42 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((γ-Glu)-(2-[2-(2-胺基-乙氧基-乙氧基]-乙醯基)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((γ-Glu)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 52 5268.88
43 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 53 5559.19
44 Y-Aib-EGT-αMeF-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 54 5541.2
45 Y-Aib-EGT-αMeF-TSD-αMeF-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 55 5554.24
46 Y-Aib-EGT-αMeF-TSD-4Pal-SI-αMeF-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 56 5575.22
47 Y-Aib-EGT-αMeF-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-E-αMeF-I-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 57 5555.23
48 Y-Aib-EGT-αMeF-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeF-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 58 5525.2
49 Y-Aib-EGT-αMeF(2F)-TSDY-aMeS-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 59 5588.23
50 Y-Aib-EGT-αMeF(2F)-TSDY-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 60 5572.23
51 Y-Aib-EGT-αMeF(2F)-TSD-αMeL-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 61 5538.22
52 Y-Aib-EGT-αMeF(2F)-TSD-aMeV-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 62 5524.19
53 Y-Aib-EGT-αMeF(2F)-TSD-Ac5c-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 63 5522.17
54 Y-Aib-EGT-αMeF(2F)-TSD-Ac6c-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 64 5536.2
55 Y-Aib-EGT-αMeF(2F)-TSD-Bip-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 65 5634.3
56 Y-Aib-EGT-αMeF(2F)-TSD-1Nal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 66 5608.26
57 Y-Aib-EGT-αMeF(2F)-TSD-2Nal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 67 5608.26
58 Y-Aib-EGT-αMeF(2F)-TSD-OMeY-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 68 5588.23
59 Y-Aib-EGT-αMeF(2F)-TSD-hTyr-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 69 5588.23
60 Y-Aib-EGT-αMeF(2F)-TSD-Nle-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 70 5524.19
61 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-E-(2ClPhe)-I-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 71 5593.64
62 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-E-(3ClPhe)-I-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 72 5593.64
63 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-E-(2FPhe)-I-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 73 5577.18
64 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-E-3FPhe-I-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 74 5577.18
65 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-E-3,5FPhe-I-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 75 5595.17
66 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-E-1Nal-I-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 76 5609.25
67 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(4-(4-三級-丁基苯基)丁醯基))AQ-Aib-EFI-(D-Glu)-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(4-(4-三級-丁基苯基)丁醯基))LIEGGPSSGAPPPS-NH2 77 5403.02
68 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(4-(4-三級-丁基苯基)丁醯基))AQ-Aib-EFIE-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(4-(4-三級-丁基苯基)丁醯基))LIEGGPSSGAPPPS-NH2 78 5403.02
69 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-IAQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)FIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeY-LIEGGPSSGAPPPS-NH2 79 5511.24
70 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-IAQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 80 5511.24
71 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-IAQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 81 5543.24
72 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-IAQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeY-LIEGGPSSGAPPPSK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-NH2 82 5640.35
73 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-IAQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)FI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 83 5511.24
74 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-IAQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)FI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 84 5543.24
75 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-IAQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)FI-(D-Glu)-αMeY-LIEGGPSSGAPPPSK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-NH2 85 5640.35
76 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )12 -CO2 H)FI-(D-Glu)-αMeY-LIEGGPSSGAPPPS-NH2 86 5236.88
77 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-CO-(CH2 )12 -CO2 H)FI-(D-Glu)-αMeY-LIEGGPSSGAPPPS-NH2 87 5817.51
78 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H)AQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H)FI-(D-Glu)-αMeY-LIEGGPSSGAPPPS-NH2 88 5268.97
79 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeY-LIEGGPSSGAPPPS-NH2 89 5236.88
80 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeY-LIEGGPSSGAPPPS-NH2 90 5817.51
81 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H)AQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H)-αMeY-LIEGGPSSGAPPPS-NH2 91 5268.97
82 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-E-αMeF-IK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeY-LIEGGPSSGAPPPS-NH2 92 5541.22
83 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeF-LIEGGPSSGAPPPS-NH2 93 5511.2
84 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-E-αMeF-IK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeF-LIEGGPSSGAPPPS-NH2 94 5525.22
85 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-E-αMeF-IK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)YLIEGGPSSGAPPPS-NH2 95 5527.2
86 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-QAQ-Aib-EFI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)GGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 96 5558.21
87 Y-Aib-EGT-αMeF(2F)-TSD-αMeF(2F)-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 97 5590.22
88 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-E-αMeF(2F)-I-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 98 5587.25
89 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 99 5557.22
90 Y-Aib-EGT-αMeF(2F)-TSDVSI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 100 5510.16
91 Y-Aib-EGT-αMeF(2F)-TSDV-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 101 5508.19
92 Y-Aib-EGT-αMeF(2F)-TSDVSI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-E-αMeF-I-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 102 5524.19
93 Y-Aib-EGT-αMeF(2F)-TSDV-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-E-αMeF-I-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 103 5522.22
94 Y-Aib-EGT-αMeF(2F)-TSD-Ac5c-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-E-αMeF-I-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 104 5536.2
95 Y-Aib-EGT-αMeF(2F)-TSD-Ac4c-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 105 5508.15
96 Y-Aib-EGT-αMeF(2F)-TSD-4CPhe-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 106 5602.22
97 Y-Aib-EGT-αMeF(2F)-TSD-ChG-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 107 5550.23
98 Y-Aib-EGT-αMeF(2F)-TSD-ChA-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 108 5564.25
99 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-E-2Nal-I-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 109 5609.25
100 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-GI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 110 5529.17
101 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LDGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 111 5502.1
102 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)GQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 112 5545.17
103 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-GFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 113 5487.13
104 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFIG-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 114 5487.13
105 Y-Aib-EGT-αMeF(2F)-TSDK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SI-αMeL-LD-Orn-IAQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)FI-(D-Glu)-αMeY-LIEGGPSSGAPPPS-NH2 115 5492.19
106 Y-Aib-EGT-αMeF(2F)-TSDK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SI-αMeL-LD-Orn-IAQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeY-LIEGGPSSGAPPPS-NH2 116 5492.19
107 Y-Aib-EGT-αMeF(2F)-TSDK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SI-αMeL-LD-Orn-IAQ-Aib-EFI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 117 5492.19
108 Y-Aib-EGT-αMeF(2F)-TSDK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SI-αMeL-LD-Orn-IAQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 118 5524.19
109 Y-Aib-EGT-αMeF(2F)-TSDK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SI-αMeL-LD-Orn-IAQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeF-I-(D-Glu)-αMeY-LIEGGPSSGAPPPS-NH2 119 5506.22
110 Y-Aib-EGT-αMeF(2F)-TSDK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SI-αMeL-LD-Orn-IAQ-Aib-E-αMeF-IK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeY-LIEGGPSSGAPPPS-NH2 120 5506.22
111 Y-Aib-EGT-αMeF(2F)-TSDK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SI-αMeL-LD-Orn-IAQ-Aib-E-αMeF-I-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 121 5506.22
112 Y-Aib-EGT-αMeF(2F)-TSDK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SI-αMeL-LD-Orn-IAQ-Aib-E-αMeF-I-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-)乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 122 5538.22
113 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeY-LIEGGPSSGAPPPS-NH2 123 5525.22
114 Y-Aib-EGT-αMeF(2F)-TSDVSI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeY-LIEGGPSSGAPPPS-NH2 124 5478.16
115 Y-Aib-EGT-αMeF(2F)-TSDV-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeY-LIEGGPSSGAPPPS-NH2 125 5476.19
116 Y-Aib-EGT-αMeF(2F)-TSD-Ac5c-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeY-LIEGGPSSGAPPPS-NH2 126 5490.18
117 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-E-αMeF-IK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeY-LIEGGPSSGAPPPS-NH2 127 5539.25
118 Y-Aib-EGT-αMeF(2F)-TSDVSI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-E-αMeF-IK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeY-LIEGGPSSGAPPPS-NH2 128 5492.19
119 Y-Aib-EGT-αMeF(2F)-TSDV-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-E-αMeF-IK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeY-LIEGGPSSGAPPPS-NH2 129 5490.22
120 Y-Aib-EGT-αMeF(2F)-TSD-Ac5c-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-E-αMeF-IK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeY-LIEGGPSSGAPPPS-NH2 130 5504.2
121 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-E-αMeF-IK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeF-LIEGGPSSGAPPPS-NH2 131 5523.25
122 Y-Aib-EGT-αMeF(2F)-TSDVSI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-E-αMeF-IK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeF-LIEGGPSSGAPPPS-NH2 132 5476.19
123 Y-Aib-EGT-αMeF(2F)-TSDV-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-E-αMeF-IK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeF-LIEGGPSSGAPPPS-NH2 133 5474.22
124 Y-Aib-EGT-αMeF(2F)-TSD-Ac5c-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-E-αMeF-IK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeF-LIEGGPSSGAPPPS-NH2 134 5488.2
125 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(7-(4-羧基苯氧基)庚醯基))AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(7-(4-羧基苯氧基)庚醯基))SSGAPPPS-NH2 135 5575.07
126 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(8-(4-羧基苯氧基)辛醯基))AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(8-(4-羧基苯氧基)辛醯基))SSGAPPPS-NH2 136 5603.12
127 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))AQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))FI-(D-Glu)-αMeY-LIEGGPSSGAPPPS-NH2 137 5643.27
128 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))AQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))-αMeY-LIEGGPSSGAPPPS-NH2 138 5627.23
129 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))AQ-Aib-EFI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))GGPSSGAPPPS-NH2 139 5627.23
130 Y-Aib-EGT-αMeF(2F)-TSDK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(4-(4-三級-丁基苯基)丁醯基))SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(4-(4-三級-丁基苯基)丁醯基))AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGPSSGAPPPS-NH2 140 5432.05
131 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(4-(4-三級-丁基苯基)丁醯基))AQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(4-(4-三級-丁基苯基)丁醯基))FI-(D-Glu)-αMeY-LIEGGPSSGAPPPS-NH2 141 5451.1
132 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(4-(4-三級-丁基苯基)丁醯基))AQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(4-(4-三級-丁基苯基)丁醯基))-αMeY-LIEGGPSSGAPPPS-NH2 142 5451.1
133 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(4-(4-三級-丁基苯基)丁醯基))AQ-Aib-EFI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(4-(4-三級-丁基苯基)丁醯基))GGPSSGAPPPS-NH2 143 5451.1
134 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(4-(4-三級-丁基苯基)丁醯基))AQ-Aib-EFI-(D-Glu)-αMeY-LIEGK((2-[2-(2-胺基-ethoxy)-乙氧基]-乙醯基)2 -(γ-Glu)-(4-(4-三級-丁基苯基)丁醯基))PSSGAPPPS-NH2 144 5523.17
135 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(4-(4-三級-丁基苯基)丁醯基))AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGPSSGAPPPSK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(4-(4-三級-丁基苯基)丁醯基))-NH2 145 5580.22
136 Y-Aib-EGT-αMeF(2F)-TSDK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGPSSGAPPPS-NH2 146 5392.08
137 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )AQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )FI-(D-Glu)-αMeY-LIEGGPSSGAPPPS-NH2 147 5411.12
138 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )AQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )-αMeY-LIEGGPSSGAPPPS-NH2 148 5411.12
139 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )AQ-Aib-EFI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )GGPSSGAPPPS-NH2 149 5411.12
140 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )AQ-Aib-EFI-(D-Glu)-αMeY-LIEGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )PSSGAPPPS-NH2 150 5483.19
141 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGPSSGAPPPSK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )-NH2 151 5540.24
142 Y-Aib-EGT-αMeF(2F)-TSD-Bzt-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 152 5614.29
143 Y-Aib-EGT-αMeF(2F)-TSD-2FA-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 153 5548.17
144 Y-Aib-EGT-αMeF(2F)-TSD-4TAA-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 154 5565.22
145 Y-Aib-EGT-αMeF(2F)-TSD-2TA-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 155 5564.23
146 Y-Aib-EGT-αMeF(2F)-TSD-3TA-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 156 5564.23
147 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-E-Bzt-I-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 157 5615.28
148 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-E-ChA-I-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 158 5565.24
149 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Orn-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 159 5588.24
150 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-Orn-FI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 160 5544.23
151 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LI-Orn-GGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 161 5544.23
152 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEG-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 162 5616.29
153 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSG-Orn-PPPS-NH2 163 5602.26
154 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPP-Orn-NH2 164 5586.26
155 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSG-Orn-PPP-Orn-NH2 165 5629.33
156 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-4Pal-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 166 5622.25
157 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-4Pal-FI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 167 5578.24
158 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFIE-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 168 5559.19
159 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFIE-αMeF-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 169 5543.19
160 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(εK)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(εK)-CO-(CH2 )12 -CO2 H)-αMeY-LIEGGPSSGAPPPS-NH2 170 5525.31
161 Y-Aib-EGT-aMeF(2F)-TSD-4Pal-SI-aMeL-LD-Orn-K(eK-gE-C14_OH)AQ-Aib-EFIK(eK-gE-C14_OH)-aMeY-LIEGGPSSGAPPPS-NH2 171 5202.91
162 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((εK)-(εK)-(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFIK((εK)-(εK)-(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeY-LIEGGPSSGAPPPS-NH2 172 5459.26
163 Y-Aib-EGT-αMeF(2F)-TSDV-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(εK)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(εK)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 173 5506.31
164 Y-Aib-EGT-αMeF(2F)-TSDV-Aib-I-αMeL-LD-Orn-K((εK)-(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((εK)-(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 174 5183.91
165 Y-Aib-EGT-αMeF(2F)-TSDV-Aib-I-αMeL-LD-Orn-K((εK)-(εK)-(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((εK)-(εK)-(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 175 5440.25
166 Y-Aib-EGT-αMeF(2F)-TSDV-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(εK)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(εK)-CO-(CH2 )12 -CO2 H)-αMeY-LIEGGPSSGAPPPS-NH2 176 5474.31
167 Y-Aib-EGT-αMeF(2F)-TSDV-Aib-I-αMeL-LD-Orn-K((εK)-(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFIK((εK)-(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeY-LIEGGPSSGAPPPS-NH2 177 5151.91
168 Y-Aib-EGT-αMeF(2F)-TSDV-Aib-I-αMeL-LD-Orn-K((εK)-(εK)-(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFIK((εK)-(εK)-(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeY-LIEGGPSSGAPPPS-NH2 178 5408.25
169 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-αMeF-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 179 5635.29
170 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Ac5c-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 180 5585.23
171 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Ac6c-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 181 5599.26
172 Y-Aib-EGT-αMeF-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )SSGAPPPS-NH2 182 5425.13
173 Y-Aib-EGT-αMeF-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )AQ-Aib-E-αMeF-I-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )SSGAPPPS-NH2 183 5439.16
174 Y-Aib-EGT-αMeF-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )AQ-Aib-E-αMeF-I-(D-Glu)-αMeF-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )SSGAPPPS-NH2 184 5423.16
175 Y-Aib-EGT-αMeF(2F)-TSDV-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )SSGAPPPS-NH2 185 5392.12
176 Y-Aib-EGT-αMeF-TSDV-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )SSGAPPPS-NH2 186 5374.13
177 Y-Aib-EGT-αMeF(2F)-TSD-V-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(4-(4-三級-丁基苯基)丁醯基))AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(4-(4-三級-丁基苯基)丁醯基))SSGAPPPS-NH2 187 5432.1
178 Y-Aib-EGT-αMeF-TSD-V-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(4-(4-三級-丁基苯基)丁醯基))AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(4-(4-三級-丁基苯基)丁醯基))SSGAPPPS-NH2 188 5414.11
179 Y-Aib-EGT-αMeF-TSDVSI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 189 5492.17
180 Y-Aib-EGT-αMeF-TSDV-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 190 5490.2
181 Y-Aib-EGT-αMeF-TSDVSI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeY-LIEGGPSSGAPPPS-NH2 191 5460.17
182 Y-Aib-EGT-αMeF-TSDV-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeY-LIEGGPSSGAPPPS-NH2 192 5458.2
183 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSG-NH2 193 5109.69
184 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-NH2 194 4878.49
185 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(εK)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(εK)-CO-(CH2 )12 -CO2 H)-NH2 195 4876.6
186 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((εK)-(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((εK)-(γ-Glu)-CO-(CH2 )12 -CO2 H)-NH2 196 4554.21
187 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((εK)-(εK)-(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((εK)-(εK)-(γ-Glu)-CO-(CH2 )12 -CO2 H)-NH2 197 4810.55
188 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeY-LIEGGPSSG-NH2 198 5077.69
189 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeY-LIEGG-NH2 199 4749.37
190 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeY-LIEG-Orn-NH2 200 4806.47
191 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-IAQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H)FIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H)-αMeY-LIEGGPSSGAPPPS-NH2 201 5253.01
192 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-IAQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 202 5253.01
193 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-IAQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 203 5285.01
194 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-IAQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H)-αMeY-LIEGGPSSGAPPPSK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H)-NH2 204 5382.13
195 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-IAQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H)FI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 205 5285.01
196 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-IAQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H)FI-(D-Glu)-αMeY-LIEGGPSSGAPPPSK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H)-NH2 206 5382.13
197 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-IAQ-Aib-EFIK((εK)-(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeY-LIEGGK((εK)-(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 207 5218.96
198 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-IAQ-Aib-EFIK((εK)-(εK)-(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeY-LIEGGK((εK)-(εK)-(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 208 5475.3
199 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Dap-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 209 5558.21
200 Y-Aib-EGT-αMeF(2F)-TSDY-Dap-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 210 5573.22
201 Y-Aib-EGT-αMeF(2F)-TSDV-Dap-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFIe-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 211 5509.18
202 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Tle-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 212 5585.27
203 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-IAQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(4-(4-三級-丁基苯基)丁醯基))-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(4-(4-三級-丁基苯基)丁醯基))GGPSSGAPPPS-NH2 213 5435.15
204 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-IAQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(4-(4-三級-丁基苯基)丁醯基))FI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(4-(4-三級-丁基苯基)丁醯基))GGPSSGAPPPS-NH2 214 5435.15
205 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-IAQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(4-(4-三級-丁基苯基)丁醯基))FI-(D-Glu)-αMeY-LIEGGPSSGAPPPSK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(4-(4-三級-丁基苯基)丁醯基))-NH2 215 5564.26
206 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-IAQ-Aib-EFI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(4-(4-三級-丁基苯基)丁醯基))GGPSSGAPPPSK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(4-(4-三級-丁基苯基)丁醯基))-NH2 216 5564.26
207 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(4-(4-三級-丁基苯基)丁醯基))AQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(4-(4-三級-丁基苯基)丁醯基))FI-(D-Glu)-αMeY-LIEGGPSSGAPPPS-NH2 217 5160.79
208 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(4-(4-三級-丁基苯基)丁醯基))AQ-Aib-EFI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(4-(4-三級-丁基苯基)丁醯基))GGPSSGAPPPS-NH2 218 5160.79
209 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(4-(4-三級-丁基苯基)丁醯基))AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGPSSGAPPPSK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(4-(4-三級-丁基苯基)丁醯基))-NH2 219 5289.9
210 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 220 5398.12
211 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Ac5c-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 221 5583.26
212 Y-Aib-EGT-αMeF(2F)-TSDV-αMeS-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 222 5524.19
213 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-αMeS-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 223 5573.22
214 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-αMeS-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeY-LIEGGPSSGAPPPS-NH2 224 5541.22
215 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-αMeS-I-αMeL-LD-Orn-IAQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)FIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeY-LIEGGPSSGAPPPS-NH2 225 5525.27
216 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-αMeS-I-αMeL-LD-Orn-IAQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 226 5525.27
217 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-αMeS-I-αMeL-LD-Orn-IAQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)FI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 227 5525.27
218 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-IAQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)FIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeY-LIEGGPSSGAPPPS-NH2 228 5509.27
219 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-IAQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 229 5509.27
220 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-IAQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)FI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 230 5509.27
221 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGPSSGAPPPSK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H)-NH2 231 5398.08
222 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-IAQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H)FI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 232 5253.01
223 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-IAQ-Aib-EFI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H)GGPSSGAPPPSK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H)-NH2 233 5382.13
224 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 234 5817.51
225 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGPSSGAPPPSK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-NH2 235 5946.62
226 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-IAQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 236 5801.55
227 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-IAQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-CO-(CH2 )12 -CO2 H)FI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 237 5801.55
228 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-IAQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-CO-(CH2 )12 -CO2 H)FI-(D-Glu)-αMeY-LIEGGPSSGAPPPSK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-NH2 238 5930.67
229 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-IAQ-Aib-EFI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-CO-(CH2 )12 -CO2 H)GGPSSGAPPPSK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-NH2 239 5930.67
230 Y-Aib-EGT-αMeF(2F)-TSDY-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)FI-(D-Glu)-αMeY-LIEGGPSSGAPPPS-NH2 240 5540.23
231 Y-Aib-EGT-αMeF(2F)-TSDY-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 241 5540.23
232 Y-Aib-EGT-αMeF(2F)-TSDY-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGPSSGAPPPSK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-NH2 242 5669.35
233 Y-Aib-EGT-αMeF(2F)-TSDY-Aib-I-αMeL-LD-Orn-IAQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 243 5524.28
234 Y-Aib-EGT-αMeF(2F)-TSDY-Aib-I-αMeL-LD-Orn-IAQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)FI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 244 5524.28
235 Y-Aib-EGT-αMeF(2F)-TSDY-Aib-I-αMeL-LD-Orn-IAQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)FI-(D-Glu)-αMeY-LIEGGPSSGAPPPSK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-NH2 245 5653.39
236 Y-Aib-EGT-αMeF(2F)-TSDY-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-acetyl)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))AQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))FI-(D-Glu)-αMeY-LIEGGPSSGAPPPS-NH2 246 5640.27
237 Y-Aib-EGT-αMeF(2F)-TSDY-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))AQ-Aib-EFI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))GGPSSGAPPPS-NH2 247 5640.27
238 Y-Aib-EGT-αMeF(2F)-TSDY-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGPSSGAPPPSK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))-NH2 248 5769.38
239 Y-Aib-EGT-αMeF(2F)-TSDY-Aib-I-αMeL-LD-Orn-IAQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))GGPSSGAPPPS-NH2 249 5624.31
240 Y-Aib-EGT-αMeF(2F)-TSDY-Aib-I-αMeL-LD-Orn-IAQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))FI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))GGPSSGAPPPS-NH2 250 5624.31
241 Y-Aib-EGT-αMeF(2F)-TSDY-Aib-I-αMeL-LD-Orn-IAQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))FI-(D-Glu)-αMeY-LIEGGPSSGAPPPSK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))-NH2 251 5753.42
242 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-IAQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(11-(4-羧基苯氧基)十一醯基)FI-(D-Glu)-αMeY-LIEGGPSSGAPPPSK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(11-(4-羧基苯氧基)十一醯基)-NH2 252 5766.46
243 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))AQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))FI-(D-Glu)-αMeY-LIEGGPSSGAPPPS-NH2 253 5625.25
244 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))AQ-Aib-EFI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))GGPSSGAPPPS-NH2 254 5625.25
245 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGPSSGAPPPSK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))-NH2 255 5754.37
246 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-IAQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))GGPSSGAPPPS-NH2 256 5609.3
247 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-IAQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))FI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))GGPSSGAPPPS-NH2 257 5609.3
248 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-IAQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))FI-(D-Glu)-αMeY-LIEGGPSSGAPPPSK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))-NH2 258 5738.41
249 Y-Aib-EGT-αMeF(2F)-TSD-2Nal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)FI-(D-Glu)-αMeY-LIEGGPSSGAPPPS-NH2 259 5576.27
250 Y-Aib-EGT-αMeF(2F)-TSD-2Nal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 260 5576.27
251 Y-Aib-EGT-αMeF(2F)-TSD-2Nal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGPSSGAPPPSK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-NH2 261 5705.38
252 Y-Aib-EGT-αMeF(2F)-TSD-2Nal-SI-αMeL-LD-Orn-IAQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 262 5560.31
253 Y-Aib-EGT-αMeF(2F)-TSD-2Nal-SI-αMeL-LD-Orn-IAQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)FI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 263 5560.31
254 Y-Aib-EGT-αMeF(2F)-TSD-2Nal-SI-αMeL-LD-Orn-IAQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)FI-(D-Glu)-αMeY-LIEGGPSSGAPPPSK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-NH2 264 5689.42
255 Y-Aib-EGT-αMeF(2F)-TSD-2Nal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H)AQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H)FI-(D-Glu)-αMeY-LIEGGPSSGAPPPS-NH2 265 5318.04
256 Y-Aib-EGT-αMeF(2F)-TSD-2Nal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 266 5318.04
257 Y-Aib-EGT-αMeF(2F)-TSD-2Nal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGPSSGAPPPSK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H)-NH2 267 5302.08
258 Y-Aib-EGT-αMeF(2F)-TSD-2Nal-SI-αMeL-LD-Orn-IAQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H)FI-(D-Glu)-αMeY-LIEGGPSSGAPPPSK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H)-NH2 268 5431.2
259 Y-Aib-EGT-αMeF(2F)-TSD-OMeY-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)FI-(D-Glu)-αMeY-LIEGGPSSGAPPPS-NH2 269 5556.23
260 Y-Aib-EGT-αMeF(2F)-TSD-OMeY-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 270 5556.23
261 Y-Aib-EGT-αMeF(2F)-TSD-OMeY-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGPSSGAPPPSK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-NH2 271 5685.35
262 Y-Aib-EGT-αMeF(2F)-TSD-OMeY-SI-αMeL-LD-Orn-IAQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 272 5540.28
263 Y-Aib-EGT-αMeF(2F)-TSD-OMeY-SI-αMeL-LD-Orn-IAQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)FI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 273 5540.28
264 Y-Aib-EGT-αMeF(2F)-TSD-OMeY-SI-αMeL-LD-Orn-IAQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)FI-(D-Glu)-αMeY-LIEGGPSSGAPPPSK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-NH2 274 5669.39
265 Y-Aib-EGT-αMeF(2F)-TSD-OMeY-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H)AQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H)FI-(D-Glu)-αMeY-LIEGGPSSGAPPPS-NH2 275 5298.01
266 Y-Aib-EGT-αMeF(2F)-TSD-OMeY-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 276 5298.01
267 Y-Aib-EGT-αMeF(2F)-TSD-OMeY-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGPSSGAPPPSK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H)-NH2 277 5427.12
268 Y-Aib-EGT-αMeF(2F)-TSD-OMeY-SI-αMeL-LD-Orn-IAQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H)FI-(D-Glu)-αMeY-LIEGGPSSGAPPPSK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H)-NH2 278 5411.16
269 Y-Aib-EGT-αMeF(2F)-TSD-Nle-SI-αMeL-LD-Orn-IAQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 279 5476.23
270 Y-Aib-EGT-αMeF(2F)-TSD-hTyr-SI-αMeL-LD-Orn-IAQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 280 5540.28
271 Y-Aib-EGT-αMeF(2F)-TSD-Nle-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H)AQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H)FI-(D-Glu)-αMeY-LIEGGPSSGAPPPS-NH2 281 5233.96
272 Y-Aib-EGT-αMeF(2F)-TSD-hTyr-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H)AQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H)FI-(D-Glu)-αMeY-LIEGGPSSGAPPPS-NH2 282 5298.01
273 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGPSSGAPPPSK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))-NH2 283 5756.34
274 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-IAQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))GGPSSGAPPPS-NH2 284 5611.27
275 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-IAQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))FI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))GGPSSGAPPPS-NH2 285 5611.27
276 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-IAQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))FI-(D-Glu)-αMeY-LIEGGPSSGAPPPSK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))-NH2 286 5740.38
277 Y-Aib-EGT-αMeF(2F)-TSD-OMeY-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))AQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))FI-(D-Glu)-αMeY-LIEGGPSSGAPPPS-NH2 287 5656.26
278 Y-Aib-EGT-αMeF(2F)-TSD-OMeY-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))AQ-Aib-EFI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))GGPSSGAPPPS-NH2 288 5656.26
279 Y-Aib-EGT-αMeF(2F)-TSD-OMeY-SI-αMeL-LD-Orn-IAQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))GGPSSGAPPPS-NH2 289 5640.31
280 Y-Aib-EGT-αMeF(2F)-TSD-OMeY-SI-αMeL-LD-Orn-IAQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))FI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))GGPSSGAPPPS-NH2 290 5640.31
281 Y-Aib-EGT-αMeF(2F)-TSD-2Nal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))AQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))FI-(D-Glu)-αMeY-LIEGGPSSGAPPPS-NH2 291 5676.3
282 Y-Aib-EGT-αMeF(2F)-TSD-2Nal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))AQ-Aib-EFI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))GGPSSGAPPPS-NH2 292 5676.3
283 Y-Aib-EGT-αMeF(2F)-TSD-2Nal-SI-αMeL-LD-Orn-IAQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))GGPSSGAPPPS-NH2 293 5660.34
284 Y-Aib-EGT-αMeF(2F)-TSD-2Nal-SI-αMeL-LD-Orn-IAQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))FI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))GGPSSGAPPPS-NH2 294 5660.34
285 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(11-(4-羧基苯氧基)十一醯基))AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGPSSGAPPPSK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(11-(4-羧基苯氧基)十一醯基))-NH2 295 5784.39
286 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-IAQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(11-(4-羧基苯氧基)十一醯基)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(11-(4-羧基苯氧基)十一醯基)GGPSSGAPPPS-NH2 296 5639.32
287 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-IAQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(11-(4-羧基苯氧基)十一醯基)FI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(11-(4-羧基苯氧基)十一醯基)GGPSSGAPPPS-NH2 297 5639.32
288 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-IAQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(11-(4-羧基苯氧基)十一醯基)FI-(D-Glu)-αMeY-LIEGGPSSGAPPPSK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(11-(4-羧基苯氧基)十一醯基)-NH2 298 5768.44
289 Y-Aib-EGT-αMeF(2F)-TSD-OMeY-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )AQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )FI-(D-Glu)-αMeY-LIEGGPSSGAPPPS-NH2 299 5440.16
290 Y-Aib-EGT-αMeF(2F)-TSD-OMeY-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )AQ-Aib-EFI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )GGPSSGAPPPS-NH2 300 5440.16
291 Y-Aib-EGT-αMeF(2F)-TSD-OMeY-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGPSSGAPPPSK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )-NH2 301 5569.27
292 Y-Aib-EGT-αMeF(2F)-TSDK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGPSSGAPPPS-NH2 302 5390.1
293 Y-Aib-EGT-αMeF(2F)-TSDK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )AQ-Aib-E-αMeF-I-(D-Glu)-αMeY-LIEGGPSSGAPPPS-NH2 303 5406.1
294 Y-Aib-EGT-αMeF(2F)-TSDK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )AQ-Aib-EFI-(D-Glu)-αMeY-LIEGG-NH2 304 4614.25
295 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )AQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )FI-(D-Glu)-αMeY-LIEGG-NH2 305 4633.3
296 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )AQ-Aib-EFI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )GG-NH2 306 4633.3
297 Y-Aib-EGT-αMeF(2F)-TSDK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )AQ-Aib-E-αMeF-I-(D-Glu)-αMeY-LIEGG-NH2 307 4628.28
298 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )AQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )FI-(D-Glu)-αMeY-LI-Orn-GGPSSGAPPPS-NH2 308 5396.15
299 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )AQ-Aib-Orn-FI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )GGPSSGAPPPS-NH2 309 5396.15
300 Y-Aib-EGT-αMeF(2F)-TSDY-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )AQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )FI-(D-Glu)-αMeY-LIEGGPSSGAPPPS-NH2 310 5424.16
301 Y-Aib-EGT-αMeF(2F)-TSDY-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )AQ-Aib-EFI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )GGPSSGAPPPS-NH2 311 5424.16
302 Y-Aib-EGT-αMeF(2F)-TSDY-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGPSSGAPPPSK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )-NH2 312 5553.28
303 Y-Aib-EGT-αMeF(2F)-TSDY-αMeS-I-αMeL-LD-Orn-IAQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 313 5540.28
304 Y-Aib-EGT-αMeF(2F)-TSDV-Aib-I-αMeL-LD-Orn-IAQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 314 5460.24
305 Y-Aib-EGT-αMeF(2F)-TSDV-αMeS-I-αMeL-LD-Orn-IAQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 315 5476.23
306 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-αMeS-I-αMeL-LD-Orn-IAQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))GGPSSGAPPPS-NH2 316 5625.3
307 Y-Aib-EGT-αMeF(2F)-TSDY-αMeS-I-αMeL-LD-Orn-IAQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))GGPSSGAPPPS-NH2 317 5640.31
308 Y-Aib-EGT-αMeF(2F)-TSDV-Aib-I-αMeL-LD-Orn-IAQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))GGPSSGAPPPS-NH2 318 5560.27
309 Y-Aib-EGT-αMeF(2F)-TSDV-αMeS-I-αMeL-LD-Orn-IAQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))GGPSSGAPPPS-NH2 319 5576.27
310 Y-Aib-EGT-αMeF(2F)-TSD-hTyr-SI-αMeL-LD-Orn-IAQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))GGPSSGAPPPS-NH2 320 5640.31
311 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-IAQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(11-(4-羧基苯氧基)十一醯基)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(11-(4-羧基苯氧基)十一醯基)GGPSSGAPPPS-NH2 321 5637.35
312 Y-Aib-EGT-αMeF(2F)-TSDY-Aib-I-αMeL-LD-Orn-IAQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(11-(4-羧基苯氧基)十一醯基)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(11-(4-羧基苯氧基)十一醯基)GGPSSGAPPPS-NH2 322 5652.36
313 Y-Aib-EGT-αMeF(2F)-TSDV-Aib-I-αMeL-LD-Orn-IAQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(11-(4-羧基苯氧基)十一醯基)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(11-(4-羧基苯氧基)十一醯基)GGPSSGAPPPS-NH2 323 5588.32
314 Y-Aib-EGT-αMeF(2F)-TSD-Nle-SI-αMeL-LD-Orn-IAQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))GGPSSGAPPPS-NH2 324 5576.27
315 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-IAQ-Aib-Orn-FIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 325 5494.3
316 Y-Aib-EGT-αMeF(2F)-TSDY-Aib-I-αMeL-LD-Orn-IAQ-Aib-Orn-FIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 326 5509.31
317 Y-Aib-EGT-αMeF(2F)-TSDV-Aib-I-αMeL-LD-Orn-IAQ-Aib-Orn-FIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 327 5445.27
318 Y-Aib-EGT-αMeF(2F)-TSDV-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)FI-(D-Glu)-αMeY-LIEGGPSSGAPPPS-NH2 328 5476.19
319 Y-Aib-EGT-αMeF(2F)-TSDV-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))AQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))FI-(D-Glu)-αMeY-LIEGGPSSGAPPPS-NH2 329 5576.22
320 Y-Aib-EGT-αMeF(2F)-TSD-hTyr-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))AQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))FI-(D-Glu)-αMeY-LIEGGPSSGAPPPS-NH2 330 5656.26
321 Y-Aib-EGT-αMeF(2F)-TSD-Nle-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))AQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))FI-(D-Glu)-αMeY-LIEGGPSSGAPPPS-NH2 331 5592.22
322 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )AQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )FI-(D-Glu)-αMeY-LIEGGPSSGAPPPS-NH2 332 5409.15
323 Y-Aib-EGT-αMeF(2F)-TSD-hTyr-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )AQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )FI-(D-Glu)-αMeY-LIEGGPSSGAPPPS-NH2 333 5440.16
324 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGPSSGAPPPSK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )-NH2 334 5538.26
325 Y-Aib-EGT-αMeF(2F)-TSDV-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 335 5476.19
326 Y-Aib-EGT-αMeF(2F)-TSDV-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))AQ-Aib-EFI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))GGPSSGAPPPS-NH2 336 5576.22
327 Y-Aib-EGT-αMeF(2F)-TSD-hTyr-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))AQ-Aib-EFI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))GGPSSGAPPPS-NH2 337 5656.26
328 Y-Aib-EGT-αMeF(2F)-TSD-Nle-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))AQ-Aib-EFI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))GGPSSGAPPPS-NH2 338 5592.22
329 Y-Aib-EGT-αMeF(2F)-TSDV-Aib-I-αMeL-LD-Orn-IAQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)FI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 339 5460.24
330 Y-Aib-EGT-αMeF(2F)-TSDV-Aib-I-αMeL-LD-Orn-IAQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))FI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))GGPSSGAPPPS-NH2 340 5560.27
331 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-IAQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(11-(4-羧基苯氧基)十一醯基)FI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(11-(4-羧基苯氧基)十一醯基)GGPSSGAPPPS-NH2 341 5637.35
332 Y-Aib-EGT-αMeF(2F)-TSD-hTyr-SI-αMeL-LD-Orn-IAQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))FI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))GGPSSGAPPPS-NH2 342 5640.31
333 Y-Aib-EGT-αMeF(2F)-TSD-Nle-SI-αMeL-LD-Orn-IAQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))FI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))GGPSSGAPPPS-NH2 343 5576.27
334 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )AQ-Aib-EFI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )GGPSSGAPPPS-NH2 344 5409.15
335 Y-Aib-EGT-αMeF(2F)-TSD-hTyr-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )AQ-Aib-EFI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )GGPSSGAPPPS-NH2 345 5440.16
336 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )12 -CO2 H)FI-(D-Glu)-αMeY-LIEGGPSSGAPPPS-NH2 346 5234.91
337 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 347 5234.91
338 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGPSSGAPPPSK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )12 -CO2 H)-NH2 348 5364.02
339 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-IAQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 349 5218.95
340 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-IAQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )12 -CO2 H)FI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 350 5218.95
341 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-IAQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )12 -CO2 H)FI-(D-Glu)-αMeY-LIEGGPSSGAPPPSK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )12 -CO2 H)-NH2 351 5348.07
342 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-IAQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 352 5799.58
343 Y-Aib-EGT-αMeF(2F)-TSDY-Aib-I-αMeL-LD-Orn-IAQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 353 5814.59
344 Y-Aib-EGT-αMeF(2F)-TSDV-Aib-I-αMeL-LD-Orn-IAQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 354 5750.55
345 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-IAQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))GGPSSGAPPPS-NH2 355 5899.61
346 Y-Aib-EGT-αMeF(2F)-TSDY-Aib-I-αMeL-LD-Orn-IAQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基)GGPSSGAPPPS-NH2 356 5914.62
347 Y-Aib-EGT-αMeF(2F)-TSDV-Aib-I-αMeL-LD-Orn-IAQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基)GGPSSGAPPPS-NH2 357 5850.58
348 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-Orn-FI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 358 5510.25
349 Y-Aib-EGT-αMeF(2F)-TSDY-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-Orn-FI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 359 5525.27
350 Y-Aib-EGT-αMeF(2F)-TSDV-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-Orn-FI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 360 5461.22
351 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))AQ-Aib-Orn-FI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))GGPSSGAPPPS-NH2 361 5610.29
352 Y-Aib-EGT-αMeF(2F)-TSDY-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))AQ-Aib-Orn-FI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))GGPSSGAPPPS-NH2 362 5625.3
353 Y-Aib-EGT-αMeF(2F)-TSDV-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))AQ-Aib-Orn-FI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))GGPSSGAPPPS-NH2 363 5561.25
354 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-IAQ-Aib-Orn-FIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))GGPSSGAPPPS-NH2 364 5594.33
355 Y-Aib-EGT-αMeF(2F)-TSDY-Aib-I-αMeL-LD-Orn-IAQ-Aib-Orn-FIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))GGPSSGAPPPS-NH2 365 5609.34
356 Y-Aib-EGT-αMeF(2F)-TSDV-Aib-I-αMeL-LD-Orn-IAQ-Aib-Orn-FIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))GGPSSGAPPPS-NH2 366 5545.3
357 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)FI-(D-Glu)-αMeY-LIEGGPSSGAPPPS-NH2 367 5525.22
358 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 368 5525.22
359 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGPSSGAPPPSK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-NH2 369 5654.34
360 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))AQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))FI-(D-Glu)-αMeY-LIEGGPSSGAPPPS-NH2 370 5334.94
361 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))AQ-Aib-EFIe-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))GGPSSGAPPPS-NH2 371 5334.94
362 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGPSSGAPPPSK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))-NH2 372 5464.05
363 Y-Aib-EGT-αMeF(2F)-TSDY-Aib-I-αMeL-LD-Orn-IAQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-CO-(CH2 )12 -CO2 H)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 373 5814.59
364 Y-Aib-EGT-αMeF(2F)-TSDY-Aib-I-αMeL-LD-Orn-IAQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 374 5814.59
365 Y-Aib-EGT-αMeF(2F)-TSDY-Aib-I-αMeL-LD-Orn-IAQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-CO-(CH2 )12 -CO2 H)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 375 5524.28
366 Y-Aib-EGT-αMeF(2F)-TSDY-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )12 -CO2 H)FI-(D-Glu)-αMeY-LIEGGPSSGAPPPS-NH2 376 5249.92
367 Y-Aib-EGT-αMeF(2F)-TSDY-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙醯基]-acetyl)-(γ-Glu)-CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 377 5249.92
368 Y-Aib-EGT-αMeF(2F)-TSDY-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGPSSGAPPPSK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )12 -CO2 H)-NH2 378 5379.03
369 Y-Aib-EGT-αMeF(2F)-TSDY-Aib-I-αMeL-LD-Orn-IAQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 379 5233.96
370 Y-Aib-EGT-αMeF(2F)-TSDY-Aib-I-αMeL-LD-Orn-IAQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )12 -CO2 H)FI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 380 5233.96
371 Y-Aib-EGT-αMeF(2F)-TSDY-Aib-I-αMeL-LD-Orn-IAQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )12 -CO2 H)FI-(D-Glu)-αMeY-LIEGGPSSGAPPPSK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )12 -CO2 H)-NH2 381 5363.08
372 Y-Aib-EGT-αMeF(2F)-TSDY-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))AQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))FI-(D-Glu)-αMeY-LIEGGPSSGAPPPS-NH2 382 5349.95
373 Y-Aib-EGT-αMeF(2F)-TSDY-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))AQ-Aib-EFI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))GGPSSGAPPPS-NH2 383 5349.95
374 Y-Aib-EGT-αMeF(2F)-TSDY-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGPSSGAPPPSK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))-NH2 384 5479.07
375 Y-Aib-EGT-αMeF(2F)-TSDY-Aib-I-αMeL-LD-Orn-IAQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))GGPSSGAPPPS-NH2 385 5334
376 Y-Aib-EGT-αMeF(2F)-TSDY-Aib-I-αMeL-LD-Orn-IAQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))FI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))GGPSSGAPPPS-NH2 386 5334
377 Y-Aib-EGT-αMeF(2F)-TSDY-Aib-I-αMeL-LD-Orn-IAQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))FI-(D-Glu)-αMeY-LIEGGPSSGAPPPSK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))-NH2 387 5463.11
378 Y-Aib-EGT-αMeF(2F)-TSDV-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))AQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))FI-(D-Glu)-αMeY-LIEGGPSSGAPPPS-NH2 388 5285.91
379 Y-Aib-EGT-αMeF(2F)-TSDV-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))AQ-Aib-EFI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))GGPSSGAPPPS-NH2 389 5285.91
380 Y-Aib-EGT-αMeF(2F)-TSDV-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGPSSGAPPPSK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))-NH2 390 5705.34
381 Y-Aib-EGT-αMeF(2F)-TSDV-Aib-I-αMeL-LD-Orn-IAQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))GGPSSGAPPPS-NH2 391 5269.95
382 Y-Aib-EGT-αMeF(2F)-TSDV-Aib-I-αMeL-LD-Orn-IAQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))FI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))GGPSSGAPPPS-NH2 392 5269.95
383 Y-Aib-EGT-αMeF(2F)-TSDV-Aib-I-αMeL-LD-Orn-IAQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))FI-(D-Glu)-αMeY-LIEGGPSSGAPPPSK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))-NH2 393 5689.38
384 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H)AQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H)FI-(D-Glu)-αMeY-LIEGGPSSGAPPPS-NH2 394 5266.99
385 Y-Aib-EGT-αMeF(2F)-TSDY-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H)AQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H)FI-(D-Glu)-αMeY-LIEGGPSSGAPPPS-NH2 395 5282.01
386 Y-Aib-EGT-αMeF(2F)-TSDV-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H)AQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H)FI-(D-Glu)-αMeY-LIEGGPSSGAPPPS-NH2 396 5217.96
387 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 397 5266.99
388 Y-Aib-EGT-αMeF(2F)-TSDY-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 398 5282.01
389 Y-Aib-EGT-αMeF(2F)-TSDV-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 399 5217.96
390 Y-Aib-EGT-αMeF(2F)-TSDV-Aib-I-αMeL-LD-Orn-QAQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 400 5475.21
391 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-QAQ-Aib-Orn-FIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 401 5509.27
392 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(10-(4-羧基苯氧基)癸醯基))AQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(10-(4-羧基苯氧基)癸醯基))FI-(D-Glu)-αMeY-LIEGGPSSGAPPPS-NH2 402 5367.03
393 Y-Aib-EGT-αMeF(2F)-TSDY-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(10-(4-羧基苯氧基)癸醯基))AQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(10-(4-羧基苯氧基)癸醯基))FI-(D-Glu)-αMeY-LIEGGPSSGAPPPS-NH2 403 5382.04
394 Y-Aib-EGT-αMeF(2F)-TSDV-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(10-(4-羧基苯氧基)癸醯基))AQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(10-(4-羧基苯氧基)癸醯基))FI-(D-Glu)-αMeY-LIEGGPSSGAPPPS-NH2 404 5318
395 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(10-(4-羧基苯氧基)癸醯基))AQ-Aib-EFI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(10-(4-羧基苯氧基)癸醯基))GGPSSGAPPPS-NH2 405 5367.03
396 Y-Aib-EGT-αMeF(2F)-TSDY-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(10-(4-羧基苯氧基)癸醯基))AQ-Aib-EFI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(10-(4-羧基苯氧基)癸醯基))GGPSSGAPPPS-NH2 406 5382.04
397 Y-Aib-EGT-αMeF(2F)-TSDV-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(10-(4-羧基苯氧基)癸醯基))AQ-Aib-EFI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(10-(4-羧基苯氧基)癸醯基))GGPSSGAPPPS-NH2 407 5318
398 Y-Aib-EGT-αMeF(2F)-TSDV-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )12 -CO2 H)FI-(D-Glu)-αMeY-LIEGGPSSGAPPPS-NH2 408 5185.88
399 Y-Aib-EGT-αMeF(2F)-TSDV-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 409 5185.88
400 Y-Aib-EGT-αMeF(2F)-TSDV-Aib-I-αMeL-LD-Orn-IAQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 410 5169.92
401 Y-Aib-EGT-αMeF(2F)-TSDY-Aib-I-αMeL-LD-Orn-QAQ-Aib-Orn-FIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 411 5524.28
402 Y-Aib-EGT-αMeF(2F)-TSDY-Aib-I-αMeL-LD-Orn-QAQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))GGPSSGAPPPS-NH2 412 5639.28
403 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-QAQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))GGPSSGAPPPS-NH2 413 5624.27
404 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-K(PEG3-(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-K(PEG3-(γ-Glu)-CO-(CH2 )12 -CO2 H)FI-(D-Glu)-αMeY-LIEGGPSSGAPPPS-NH2 414 5351.07
405 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-K(PEG4-(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-K(PEG4-(γ-Glu)-CO-(CH2 )12 -CO2 H)FI-(D-Glu)-αMeY-LIEGGPSSGAPPPS-NH2 415 5439.17
406 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)FI-(D-Glu)-αMeY-LI-Orn-GGPSSGAPPPS-NH2 416 5510.25
407 Y-Aib-EGT-αMeF(2F)-TSDV-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)FI-(D-Glu)-αMeY-LI-Orn-GGPSSGAPPPS-NH2 417 5461.22
408 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))AQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))FI-(D-Glu)-αMeY-LI-Orn-GGPSSGAPPPS-NH2 418 5610.29
409 Y-Aib-EGT-αMeF(2F)-TSDY-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))AQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))FI-(D-Glu)-αMeY-LI-Orn-GGPSSGAPPPS-NH2 419 5625.3
410 Y-Aib-EGT-αMeF(2F)-TSDV-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))AQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))FI-(D-Glu)-αMeY-LI-Orn-GGPSSGAPPPS-NH2 420 5561.25
411 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-QAQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 421 5524.24
412 Y-Aib-EGT-αMeF(2F)-TSDY-Aib-I-αMeL-LD-Orn-QAQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 422 5539.25
413 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )AQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )FI-(D-Glu)-αMeY-LI-Orn-GGPSSGAPPPS-NH2 423 5394.18
414 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )AQ-Aib-Orn-FI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )GGPSSGAPPPS-NH2 424 5394.18
415 Y-Aib-EGT-αMeF(2F)-TSDK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )AQ-Aib-4Pal-FI-(D-Glu)-αMeY-LIEGGPSSGAPPPS-NH2 425 5409.15
416 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )AQ-Aib-4Pal-FI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )GGPSSGAPPPS-NH2 426 5428.2
417 Y-Aib-EGT-αMeF(2F)-TSDK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )AQ-Aib-Orn-FI-(D-Glu)-αMeY-LIEGGPSSGAPPPS-NH2 427 5375.13
418 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )AQ-Aib-Orn-FI-(D-Glu)-αMeY-LIEGGPSSGAPPPSK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )-NH2 428 5523.3
419 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )AQ-Aib-TFI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )GGPSSGAPPPS-NH2 429 5381.14
420 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )AQ-Aib-4Pal-FI-(D-Glu)-αMeY-LIEGGPSSGAPPPSK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )-NH2 430 5557.31
421 Y-Aib-EGT-αMeF(2F)-TSDK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-CO-(CH2 )10 -CH3 )-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-CO-(CH2 )10 -CH3 )AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGPSSGAPPPS-NH2 431 5680.42
422 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-CO-(CH2 )10 -CH3 )AQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-CO-(CH2 )10 -CH3 )FI-(D-Glu)-αMeY-LIEGGPSSGAPPPS-NH2 432 5699.46
423 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-CO-(CH2 )10 -CH3 )AQ-Aib-EFI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-CO-(CH2 )10 -CH3 )GGPSSGAPPPS-NH2 433 5699.46
424 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-CO-(CH2 )10 -CH3 )AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGPSSGAPPPSK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-CO-(CH2 )10 -CH3 )-NH2 434 5828.58
425 Y-Aib-EGT-αMeF(2F)-TSDK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )10 -CH3 )-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )10 -CH3 )AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGPSSGAPPPS-NH2 435 5099.79
426 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )10 -CH3 )AQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )10 -CH3 )FI-(D-Glu)-αMeY-LIEGGPSSGAPPPS-NH2 436 5118.84
427 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )10 -CH3 )AQ-Aib-EFI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )10 -CH3 )GGPSSGAPPPS-NH2 437 5118.84
428 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )10 -CH3 )AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGPSSGAPPPSK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )10 -CH3 )-NH2 438 5247.95
429 Y-Aib-EGT-αMeF(2F)-TSDK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )AQ-Aib-E-αMeF-I-(D-Glu)-αMeY-LIEGGPSSGAPPPS-NH2 439 5404.13
430 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )AQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )- αMeF-I-(D-Glu)-αMeY-LIEGGPSSGAPPPS-NH2 440 5423.18
431 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )AQ-Aib-E-αMeF-I-(D-Glu)-αMeY-LIEGGPSSGAPPPSK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )-NH2 441 5552.29
432 Y-Aib-EGT-αMeF(2F)-TSDK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-CO-(CH2 )10 -CH3 )-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-CO-(CH2 )10 -CH3 )AQ-Aib-Orn-FI-(D-Glu)-αMeY-LIEGGPSSGAPPPS-NH2 442 5665.45
433 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-CO-(CH2 )10 -CH3 )AQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-CO-(CH2 )10 -CH3 )FI-(D-Glu)-αMeY-LI-Orn-GGPSSGAPPPS-NH2 443 5599.39
434 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-CO-(CH2 )10 -CH3 )AQ-Aib-Orn-FI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-CO-(CH2 )10 -CH3 )GGPSSGAPPPS-NH2 444 5684.5
435 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-CO-(CH2 )10 -CH3 )AQ-Aib-Orn-FI-(D-Glu)-αMeY-LIEGGPSSGAPPPSK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-CO-(CH2 )10 -CH3 )-NH2 445 5813.61
436 Y-Aib-EGT-αMeF(2F)-TSDK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-CO-(CH2 )10 -CH3 )-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-CO-(CH2 )10 -CH3 )AQ-Aib-E-αMeF-I-(D-Glu)-αMeY-LIEGGPSSGAPPPS-NH2 446 5694.44
437 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-CO-(CH2 )10 -CH3 )AQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-CO-(CH2 )10 -CH3 )- αMeF-I-(D-Glu)-αMeY-LIEGGPSSGAPPPS-NH2 447 5729.53
438 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-CO-(CH2 )10 -CH3 )AQ-Aib-E-αMeF-I-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-CO-(CH2 )10 -CH3 )GGPSSGAPPPS-NH2 448 5713.49
439 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-CO-(CH2 )10 -CH3 )AQ-Aib-E-αMeF-I-(D-Glu)-αMeY-LIEGGPSSGAPPPSK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-CO-(CH2 )10 -CH3 )-NH2 449 5842.6
440 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-QAQ-Aib-Orn-FIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))GGPSSGAPPPS-NH2 450 5609.3
441 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-G-αMeL-LD-Orn-QAQ-Aib-Orn-FIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 451 5453.16
442 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-QAQ-Aib-Orn-FIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(11-(4-羧基苯氧基)十一醯基)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(11-(4-羧基苯氧基)十一醯基)GGPSSGAPPPS-NH2 452 5637.35
443 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-QAQ-Aib-Orn-FIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )14 -CO2 )-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )14 -CO2 )GGPSSGAPPPS-NH2 453 5565.38
444 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-QAQ-Aib-4Pal-FIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 454 5543.29
445 Y-Aib-EGT-αMeF(2F)-TSDK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )-Aib-I-αMeL-LDGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGPSSGAPPPS-NH2 455 5333.01
446 Y-Aib-EGT-αMeF(2F)-TSDV-Aib-I-αMeL-LD-Orn-QAQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))GGPSSGAPPPS-NH2 456 5575.24
447 Y-Aib-EGT-αMeF(2F)-TSDV-Aib-I-αMeL-LD-Orn-QAQ-Aib-Orn-FIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))GGPSSGAPPPS-NH2 457 5560.27
448 Y-Aib-EGT-αMeF(2F)-TSDV-Aib-I-αMeL-LD-Orn-QAQ-Aib-Orn-FIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 458 5460.24
449 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-QAQ-Aib-Orn-FIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-Ahx-(γ-Glu)-CO-(CH2 )12 -CO2 )-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-Ahx-(γ-Glu)-CO-(CH2 )12 -CO2 )GGPSSGAPPPS-NH2 459 5445.27
450 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-QAQ-Aib-Orn-FIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-Aoc-(γ-Glu)-CO-(CH2 )12 -CO2 )-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-Aoc-(γ-Glu)-CO-(CH2 )12 -CO2 )GGPSSGAPPPS-NH2 460 5501.38
451 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-QAQ-Aib-Orn-FIK(Ahx-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )12 -CO2 )-αMeY-LIK(Ahx-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )12 -CO2 )GGPSSGAPPPS-NH2 461 5445.27
452 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-QAQ-Aib-Orn-FIK(Aoc-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )12 -CO2 )-αMeY-LIK(Aoc-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )12 -CO2 )GGPSSGAPPPS-NH2 462 5501.38
453 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-QAQ-Aib-Orn-FIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-Ahx-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-Ahx-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))GGPSSGAPPPS-NH2 463 5545.3
454 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-QAQ-Aib-Orn-FIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-Aoc-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-Aoc-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))GGPSSGAPPPS-NH2 464 5601.41
455 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-QAQ-Aib-Orn-FIK(Ahx-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))-αMeY-LIK(Ahx-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))GGPSSGAPPPS-NH2 465 5545.3
456 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-QAQ-Aib-Orn-FIK(Aoc-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))-αMeY-LIK(Aoc-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))GGPSSGAPPPS-NH2 466 5601.41
457 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-QAQ-Aib-Orn-FIK(PEG4-(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeY-LIK(PEG4-(γ-Glu)-CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 467 5423.22
458 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-QAQ-Aib-Orn-FIK(PEG3-(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeY-LIK(PEG3-(γ-Glu)-CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 468 5335.11
459 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-QAQ-Aib-Orn-FIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 469 5218.96
460 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-QAQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 470 5814.55
461 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-QAQ-Aib-Orn-FIK(PEG4-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))-αMeY-LIK(PEG4-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))GGPSSGAPPPS-NH2 471 5523.25
462 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-QAQ-Aib-Orn-FIK(PEG3-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))-αMeY-LIK(PEG3-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))GGPSSGAPPPS-NH2 472 5435.15
463 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-QAQ-Aib-Orn-FIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))GGPSSGAPPPS-NH2 473 5318.99
464 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-QAQ-Aib-EFIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基)GGPSSGAPPPS-NH2 474 5914.58
465 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-K(((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-Aoc-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIK(((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-Aoc-CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 475 5259.1
466 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-QAQ-Aib-Orn-FIK(PEG6-(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeY-LIK(PEG6-(γ-Glu)-CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 476 5599.43
467 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-QAQ-Aib-Orn-FIK(PEG5-(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeY-LIK(PEG5-(γ-Glu)-CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 477 5511.33
468 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-QAQ-Aib-Orn-FIK(PEG6-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))-αMeY-LIK(PEG6-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))GGPSSGAPPPS-NH2 478 5699.46
469 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-QAQ-Aib-Orn-FIK(PEG5-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))-αMeY-LIK(PEG5-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))GGPSSGAPPPS-NH2 479 5611.36
470 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-QAQ-Aib-Orn-FIK(((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 --Trx-(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeY-LIK(((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 --Trx-(γ-Glu)-CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 480 5787.66
471 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-QAQ-Aib-Orn-FIK(((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 --Trx-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))-αMeY-LIK(((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 --Trx-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))GGPSSGAPPPS-NH2 481 5887.69
472 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-QAQ-Aib-Orn-FIK(((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-Trx-(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeY-LIK(((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-Trx-(γ-Glu)-CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 482 5497.35
473 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-QAQ-Aib-Orn-FIK(((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-Trx-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))-αMeY-LIK(((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-Trx-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))GGPSSGAPPPS-NH2 483 5597.38
474 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-QAQ-Aib-Orn-FIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)2 -CO-(CH2 )12 -CO2 H)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)2 -CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 484 5767.5
475 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-QAQ-Aib-Orn-FIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)2 --(10-(4-羧基苯氧基)癸醯基))-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)2 --(10-(4-羧基苯氧基)癸醯基))GGPSSGAPPPS-NH2 485 5867.53
476 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-QAQ-Aib-Orn-FIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 486 5799.58
477 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-QAQ-Aib-Orn-FIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)--(10-(4-羧基苯氧基)癸醯基))-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)--(10-(4-羧基苯氧基)癸醯基))GGPSSGAPPPS-NH2 487 5899.61
478 Y-Aib-EGT-αMeF(2F)-TSDY-Aib-I-αMeL-LD-Orn-IAQ-Aib-Orn-FIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-CO-(CH2 )12 -CO2 H )GGPSSGAPPPS-NH2 488 5799.62
479 Y-Aib-EGT-αMeF(2F)-TSDY-Aib-I-αMeL-LD-Orn-QAQ-Aib-Orn-FIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 489 5814.59
480 Y-Aib-EGT-αMeF(2F)-TSDY-Aib-I-αMeL-LD-Orn-QAQ-Aib-Orn-FIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)2 -CO-(CH2 )12 -CO2 H)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)2 -CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 490 5782.51
481 Y-Aib-EGT-αMeF(2F)-TSDY-Aib-I-αMeL-LD-Orn-IAQ-Aib-Orn-FIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)--(10-(4-羧基苯氧基)癸醯基))-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)--(10-(4-羧基苯氧基)癸醯基))GGPSSGAPPPS-NH2 491 5899.65
482 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-QAQ-Aib-Orn-FIK((γ-Glu)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeY-LIK((γ-Glu)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 492 5767.5
483 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-QAQ-Aib-Orn-FIK((γ-Glu)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))-αMeY-LIK((γ-Glu)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))GGPSSGAPPPS-NH2 493 5867.53
484 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-QAQ-Aib-Orn-FIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 494 5767.5
485 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-QAQ-Aib-Orn-FIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))GGPSSGAPPPS-NH2 495 5867.53
486 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-QAQ-Aib-Orn-FIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)3 -CO-(CH2 )12 -CO2 H)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)3 -CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 496 5735.41
487 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-QAQ-Aib-Orn-FIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)3 -(10-(4-羧基苯氧基)癸醯基))-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)3 --(10-(4-羧基苯氧基)癸醯基))GGPSSGAPPPS-NH2 497 5835.44
488 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-QAQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)FI-(D-Glu)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 498 5524.24
489 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-QAQ-Aib-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)FI-(D-Glu)-αMeY-LIEGGPSSGAPPPSK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-NH2 499 5653.35
490 Y-Aib-EGT-αMeF(2F)-TSD-Nle-SI-αMeL-LD-Orn-QAQ-Aib-Orn-FIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 500 5474.27
491 Y-Aib-EGT-αMeF(2F)-TSD-hY-SI-αMeL-LD-Orn-QAQ-Aib-Orn-FIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)GGPSSGAPPPS-NH2 501 5538.31
492 Y-Aib-EGT-αMeF(2F)-TSDY-Aib-I-αMeL-LD-Orn-QAQ-Aib-Orn-FIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)--C10_4CP)-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)--C10_4CP)GGPSSGAPPPS-NH2 502 5624.31
493 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-Aib-I-αMeL-LD-Orn-QAQ-Aib-4Pal-FIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))-αMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))GGPSSGAPPPS-NH2 503 5643.32
494 Y-Aib-EGT-aMeF(2F)-TSD-4Pal-Aib-I-aMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )AQ-Aib-GFIe-aMeY-LIK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )GGPSSGAPPPS-NH2 504 5337.09
結合分析 升糖素(稱為Gcg)為禮來公司(Eli Lilly and Company)製備的參考標準物。GLP-1，7-36-NH2 (稱為GLP-1)獲自CPC Scientific (Sunnyvale, CA，97.2%純度，100 µM於100% DMSO中的等分試樣)。在禮來公司研究實驗室(Lilly Research Laboratories)使用肽合成及HPLC層析法如上文所述來製備GIP 1-42 (稱為GIP)(＞80%純度，100 µM於100% DMSO中的等分試樣)。[125 I]放射性標記之Gcg、GLP-1或GIP係使用[125 I]-乳過氧化酶製備，且係獲自Perkin Elmer (Boston, MA)。
藉由將受體cDNA次選殖至pcDNA3表現質體中來製備經穩定轉染之細胞株且轉染至人胚腎(HEK) 293 (hGcgR及hGLP-1R)或中國倉鼠卵巢(CHO) (hGIPR)細胞中，隨後用遺傳黴素(hGLP-1R及hGIPR)或潮黴素B (hGcgR)選擇。
使用兩種方法製備粗細胞膜。
方法 1 ：將經冷凍之細胞離心塊在冰上溶解於含有50 mM Tris HCl (pH 7.5)及具有EDTA之Roche Complete™蛋白酶抑制劑之低張緩衝液中。使用裝配有Teflon® 研杵的Potter-Elvehjem玻璃均質器使細胞懸浮液破碎歷時25衝程。使勻漿在4℃下以1100 × g離心10分鐘。收集上清液且在冰上儲存，同時使離心塊再懸浮於均質化緩衝液中且如上文所述再均質化。使勻漿以1100 × g離心10分鐘。將第二上清液與第一上清液合併且在4℃下以35000 × g離心1小時。將所得膜離心塊再懸浮於含有約1至3 mg/mL蛋白酶抑制劑之均質化緩衝液中，在液氮中快速冷凍且以等分試樣形式儲存於-80℃冷凍器中直至使用。
方法 2 ：將經冷凍之細胞離心塊在冰上溶解於含有50 mM Tris HCl (pH 7.5)、1 mM MgCl2 、Roche Complete™無EDTA蛋白酶抑制劑及25個單位/ml DNA酶I (Invitrogen)之低張緩衝液中。使用裝配有Teflon® 研杵的Potter-Elvehjem玻璃均質器使細胞懸浮液破碎20至25衝程。使勻漿在4℃下以1800 × g離心15分鐘。收集上清液且在冰上儲存，同時使離心塊再懸浮於均質化緩衝液(不含DNA酶I)中且如上文所述再均質化。使勻漿以1800 × g離心15分鐘。將第二上清液與第一上清液合併且以1800×g又離心15分鐘。接著使總上清液在4℃下以25000 × g離心30分鐘。將所得膜離心塊再懸浮於含有約1至3 mg/mL蛋白酶抑制劑之均質化緩衝液(不含DNA酶I)中且以等分試樣形式儲存於-80℃冷凍器中直至使用。
結合測定方法 由於[125 I]儲備材料中的高丙醇含量，因此利用同源競爭結合分析，而非飽和結合來測定各種受體/放射性配位體相互作用之平衡結合解離常數(Kd )。針對受體製劑所測定之Kd 值係如下：hGcgR (3.9 nM)、hGLP-1R (1.2 nM)及hGIPR (0.14 nM)。
[125 I]- 升糖素結合 使用具有麥胚凝集素(wheat germ agglutinin；WGA)珠粒(Perkin Elmer)之閃爍近接分析(Scintillation Proximity Assay；SPA)形式進行人類Gcg受體結合分析。結合緩衝液含有25 mM 4-(2-羥乙基)-1-哌𠯤乙磺酸(HEPES) (pH 7.4)、2.5 mM CaCl2 、1 mM MgCl2 、0.1% (重量體積比)枯草桿菌素(Research Products)、0.003% (重量體積比)聚氧化乙烯山梨聚糖單月桂酸酯(TWEEN® -20)及不具有EDTA之Roche Complete™蛋白酶抑制劑。將肽及Gcg解凍且在100% DMSO中進行3倍連續稀釋(10點濃度反應曲線)。接著，將5 µL連續稀釋的化合物或DMSO轉移至含有45 µL分析結合緩衝液或未標記Gcg對照物(非特異性結合或NSB，最終1 µM)的Corning® 3632透明底分析盤中。接著使用Biotek Multiflo分配器添加50 µL [125 I]-Gcg (最終0.15 nM)、50 µL人類GcgR膜(1.5 µg/孔)及50 µL WGA SPA珠粒(80至150 µg/孔)。將盤密封且在盤振盪器(設定6)上混合1分鐘，且在室溫下經歷12小時培育/沈降時間之後，用PerkinElmer Trilux MicroBeta® 閃爍計數器讀取讀數。所測試肽在反應曲線中之最終分析濃度範圍通常為1150 nM至0.058 nM，且對於對照物Gcg而言，為1000 nM至0.05 nM。
[125 I]-GLP-1 結合 使用具有WGA珠粒之SPA形式進行人類GLP-1受體結合分析。結合緩衝液含有25 mM HEPES (pH 7.4)、2.5 mM CaCl2 、1 mM MgCl2 、0.1% (重量體積比)枯草桿菌素、0.003% (重量體積比) TWEEN® -20及不具有EDTA之Roche Complete™蛋白酶抑制劑。將肽及GLP-1解凍且在100% DMSO中進行3倍連續稀釋(10點濃度反應曲線)。接著，將5 µL連續稀釋的化合物或DMSO轉移至含有45 µL分析結合緩衝液或未標記GLP-1對照物(非特異性結合或NSB，最終0.25 µM)的Corning® 3632透明底分析盤中。接著用Biotek Multiflo分配器添加50 µL [125 I]-GLP-1 (最終0.15 nM)、50 µL人類GLP-1R膜(0.5 µg/孔)及50 µL WGA SPA珠粒(100至150 µg/孔)。將盤密封且在盤振盪器(設定6)上混合1分鐘，且在室溫下經歷5至12小時培育/沈降時間之後，用PerkinElmer Trilux MicroBeta® 閃爍計數器讀取讀數。所測試肽在反應曲線中的最終分析濃度範圍典型地為1150 nM至0.058 nM且對於對照物GLP-1而言，為250 nM至0.013 nM。
[125I]-GIP 結合 使用具有WGA珠粒之SPA形式進行人類GIP受體結合分析。結合緩衝液含有25 mM HEPES (pH 7.4)、2.5 mM CaCl2 、1 mM MgCl2 、0.1% (重量體積比)枯草桿菌素、0.003% (重量體積比) TWEEN® -20及不具有EDTA之Roche Complete™蛋白酶抑制劑。將肽及GIP解凍且在100% DMSO中進行3倍連續稀釋(10點濃度反應曲線)。接著，將5 µL連續稀釋的化合物或DMSO轉移至含有45 µL分析結合緩衝液或未標記GIP對照物(非特異性結合或NSB，最終0.25 µM)的Corning® 3632透明底分析盤中。接著使用Biotek Multiflo分配器添加50 µL [125 I]-GIP (最終0.075-0.15 nM)、50 µL人類GIPR膜(3 µg/孔)及50 µL WGA SPA珠粒(100至150 µg/孔)。將盤密封且在盤振盪器(設定6)上混合1分鐘，且在室溫下經歷2.5至12小時培育/沈降時間之後，用PerkinElmer Trilux MicroBeta® 閃爍計數器讀取讀數。所測試肽在反應曲線中之最終分析濃度範圍通常為1150 nM至0.058 nM或115 nM至0.0058 nM，且對於對照物GIP而言，為250 nM至0.013 nM。
結合分析資料之分析 藉由個別CPM值減去非特異性結合(分別在存在過量未標記之Gcg、GLP-1或GIP之情況下結合)且除以總結合信號(亦藉由減去非特異性結合來校正)而將肽、Gcg、GLP-1或GIP之濃度曲線的原始CPM資料轉換為抑制百分比。使用四參數(曲線最大值、曲線最小值、IC50 、希爾斜率(Hill slope))非線性回歸常式(Genedata Screener, 12.0.4版, Genedata AG, Basal, Switzerland)分析資料。基於方程式Ki = IC50 /(1 + D/Kd )，由絕對IC50 值計算親和力常數(Ki )，其中D為實驗中使用之放射性配位體之濃度，IC50 為引起結合之50%抑制的濃度且Kd 為放射性配位體之平衡結合解離常數(上文所述)。Ki 值報告為幾何平均值，其中誤差表示為平均值標準誤差(SEM)，且n等於獨立重複實驗之數目(在不同日進行之分析中確定)。幾何平均值如下計算： 幾何平均值 = 10(Log Ki值之算術平均值)) 計算各種受體及各物種之Ki比率(原生對照肽之Ki/測試化合物之Ki)。Ki比率快速地指示肽相較於原生對照肽之表觀親和力。Ki比率＜1表示測試肽對受體具有低於原生肽之親和力(較高Ki值)，而Ki比率＞1則表示測試肽對受體具有高於原生肽之親和力(較低Ki值)。
n=1/x意謂總重複實驗數目(x)中僅一個值用於表示平均值。當存在n=2或更大不合格結果時，計算SEM。平均值表示為幾何平均值，其在括弧中指出平均值標準誤差(SEM)及重複實驗數目(n)。
表 1. 所指定實例及比較例分子對人類GLP-1R、GcgR及GIPR之活體外結合親和力(Ki )。 結合親和力
   Ki ，nM (SEM，n)
分子或實例 hGIPR hGLP-1R hGCGR
hGIP(1-42)NH2 0.135 (0.00585, 378/380)      
hGLP-1(7-36)NH2    0.791 (0.0236, 545)   
hGCG       3.07 (0.115, 510/511)
1 0.0880 (0.0147, 3) 2.33 (0.341, 3) ＞969 (1/3)
2 0.0446 1.04 ＞958
3 0.0629 0.471 711
4 0.0528 (0.0149, 2) 0.413 (0.0153, 2) 637 (12.3, 2)
5 0.0309 (0.00250, 3) 0.154 (0.0391, 3) 44.8 (53.4, 3)
6 0.145 2.99 ＞969
7 0.0501 (0.00636, 3) 0.362 (0.101, 3) 1.46 (0.930, 3)
8 0.0240 (0.00569, 3) 0.139 (0.0154, 3) 4.29 (4.32, 3)
9 0.0557 (0.00698, 3) 1.05 (0.0625, 3) 209 (1/3)
10 0.0489 (0.00825, 2) 0.681 (0.0423, 2) 424 (214, 2)
11 0.0508 (0.00450, 2) 1.06 (0.222, 2) 660 (24.3, 2)
12 0.0575 (0.00224, 2) 0.638 (0.249, 2) 213 (27.9, 2)
13 0.0575 (0.0351, 2) 0.691 (0.304, 2) 0.987 (0.0552, 2)
14 0.0360 (0.00828, 2) 0.286 (0.170, 2) 17.6 (0.912, 2)
15 0.0629 (0.00467, 3) 2.11 (0.383, 3) ＞966 (1/3)
16 0.0540 (0.0165, 3) 1.40 (0.275, 3) 707 (53.3, 2/3)
17 0.0649 (0.0248, 3) 3.18 (0.127, 3) ＞966 (1/3)
18 0.0769 (0.0200, 2) 8.41 (2.71, 2) ＞958 (1/2)
19 0.0807 (0.00750, 3) 3.13 (0.185, 3) ＞966 (1/3)
20 0.0722 (0.00347, 4) 1.96 (0.319, 4) 139 (27.5, 4)
21 0.0231 (0.00290, 3) 0.246 (0.0413, 3) 0.293 (0.0186, 3)
22 0.0217 (0.00493, 3) 0.301 (0.0914, 3) 0.596 (0.0330, 3)
23 0.0238 (0.00306, 3) 0.251 (0.0187, 3) 1.18 (0.130, 3)
24 0.0361 (0.00975, 3) 0.520 (0.0555, 3) 0.646 (0.0169, 3)
25 0.0293 (0.0105, 3) 0.483 (0.0966, 3) 0.283 (0.0162, 3)
26 0.0863 (0.00997, 3) 0.867 (0.300, 3) 3.82 (0.560, 3)
27 0.378 (0.140, 2) 6.48 (1.80, 2) ＞958 (1/2)
28 0.0972 (0.00197, 2) 3.01 (0.442, 2) ＞966 (1/2)
29 0.0505 0.412 0.923
30 0.0653 (0.0190, 2) 2.66 (0.303, 2) ＞966 (1/2)
31 0.0308 0.315 0.62
33 0.117 1.34 264
34 0.131 2.81 ＞957
35 0.077 1.38 868
36 0.103 1.47 611
37 0.171 2.22 ＞957
38 0.0608 0.803 174
39 0.234 1.69 412
40 0.163 1.6 223
41 0.108 2.06 ＞957
42 0.0759 2.02 458
43 0.092 2.5 ＞957
44 0.0595 3.08 ＞966
45 0.0891 6.9 ＞966
46 0.0683 6.1 ＞966
47 0.0761 29 217
48 0.0621 3.67 ＞966
49 0.0573 1.21 196
50 0.0296 0.876 42
51 0.0741 1.64 51.7
52 0.0832 1.16 ＞966
53 0.085 1.46 274
55 0.252 5.17 299
56 0.152 2.85 137
57 0.297 4.35 114
58 0.208 1.15 1920
59 0.171 0.789 2000
60 0.11 0.872 737
62 0.132 1.59 ＞4780
64 0.161 1.52 ＞4780
65 0.121 1.05 4290
66 0.263 1.55 4150
70 0.120 (0.0470, 2) 1.67 (0.736, 4) 151
73 0.0454 3.38 53.9
75 0.107 2.8 206
78 0.0627 0.881 (0.349, 4) 625
91 0.126 1.26 (0.316, 4) ＞955
128 0.0314 0.777 (0.202, 4) ＞955
137 0.0403 0.250 (0.0518, 4) 8.29
139 0.0415 (0.00520, 2) 0.268 (0.0773, 4) 109
141 0.0291 (0.00776, 2) 0.194 (0.0837, 4) 13.9
212 0.161 1.17 (0.333, 4) ＞955
216 0.0491 0.863 (0.505, 4) 328
219 0.114 0.939 (0.627, 4) 135
246 0.0432 (0.00892, 2) 0.557 44.6
292 0.0161 (0.00313, 5) 0.289 (0.0849, 5) 132 (25.5, 5)
293 0.022 0.211 23.1
298 0.0131 0.119 14.3
299 0.0215 0.101 93.3
302 0.0228 0.137 2.84
322 0.0162 (0.00203, 5) 0.234 (0.0542, 5) 2.91 (0.693, 5)
324 0.0163 (0.00117, 5) 0.168 (0.0289, 5) 6.28 (0.938, 5)
334 0.0195 (0.00139, 5) 0.325 (0.0497, 5) 75.5 (12.7, 5)
336 0.0782 1.85 230
337 0.0747 2.17 ＞957
338 0.091 2.07 ＞957
360 0.046 0.673 118
361 0.0578 1.22 238
362 0.053 0.765 360
391 0.0279 (0.00204, 4) 0.346 (0.0663, 3) 289 (41.4, 3)
403 0.0375 0.424 134
411 0.0375 (0.00780, 2) 1.33 ＞957
414 0.0229 (0.000330, 3) 0.194 (0.0265, 3) 33.7 (5.31, 3)
415 0.0152 (0.00797, 2) 0.156 (0.109, 2) 51.8 (18.2, 2)
417 0.0214 (0.00497, 3) 0.167 (0.0783, 3) 58.4 (7.11, 3)
418 0.0174 (0.00276, 2) 0.0684 3.59 (1.87, 2)
419 0.0166 0.265 60.6
421 0.0245 (0.00418, 3) 0.198 (0.0413, 3) 345 (101, 3)
422 0.0218 (0.00310, 3) 0.194 (0.0162, 3) 12.2 (1.63, 3)
423 0.0207 (0.00795, 3) 0.275 (0.0192, 3) 85.9 (10.6, 3)
424 0.0206 (0.00786, 3) 0.219 (0.0306, 3) 16.0 (1.93, 3)
432 0.0134 (0.00295, 2) 0.134 (0.00717, 2) 356 (72.8, 2)
433 0.0175 0.187 28.3
434 0.00965 (0.00495, 2) 0.150 (0.0253, 2) 81.2 (12.2, 2)
435 0.00910 (0.000766, 2) 0.122 (0.00471, 2) 14.4 (1.56, 2)
436 0.0372 0.412 64.9
440 0.0312 (0.00264, 3) 0.373 (0.118, 3) 131 (27.8, 3)
441 0.0539 (0.0323, 2) 0.386 (0.0706, 2) 592 (1/2)
442 0.0507 0.164 130
446 0.0369 (0.00841, 2) 0.382 (0.116, 2) 109 (11.0, 2)
448 0.0314 (0.00845, 2) 0.367 (0.103, 2) 116 (13.5, 2)
449 0.0133 0.201 243
451 0.0239 0.234 258
453 0.013 0.123 71.8
455 0.0143 0.243 60.1
457 0.0419 (0.0217, 2) 0.252 (0.0198, 2) 351 (0.454, 2)
458 0.0232 0.266 170
459 0.023 0.224 108
460 0.0528 (0.0151, 2) 0.433 (0.0173, 2) ＞959 (1/2)
461 0.0100 (0.00141, 2) 0.140 (0.0483, 2) 101 (26.9, 2)
462 0.0102 0.125 87.5
463 0.0183 0.143 54.5
464 0.0261 (0.00416, 2) 0.352 (0.0418, 2) 753 (58.6, 2)
465 0.0464 1.29 304
466 0.0199 (0.00474, 2) 0.200 (0.0377, 2) 342 (223, 2)
467 0.0486 0.381 208
468 0.0291 0.0943 269
469 0.0387 0.0847 144
470 0.0346 0.121 945
471 0.0493 0.197 452
472 0.0376 0.254 258
473 0.0319 0.169 162
474 0.0427 0.343 382
475 0.0294 0.189 139
476 0.0351 0.226 605
477 0.0279 0.143 268
478 0.0406 0.407 49.7
479 0.0249 0.246 213
480 0.0368 0.307 88.5
481 0.0266 0.326 20.1
482 0.0277 0.254 273
483 0.0236 0.263 151
484 0.0296 0.268 305
485 0.0548 0.3 121
486 0.046 0.299 115
487 0.0714 0.217 73.3
488 0.064 0.964 ＞958
489 0.0912 0.947 ＞957
490 0.0288 0.27 37.8
491 0.0301 0.182 94.4
492 0.0264 0.233 28.6
493 0.0345 0.25 70.1
494 0.0197 (0.00489, 2) 0.188 (0.0462, 2) 135 (26.5, 2)
功能活性
功能hGIP-R、hGLP-1R及hGCGR分析 方法：使用表現hGIPR、hGLP-1R或hGCGR之HEK-293純系細胞株中的cAMP形成來測定功能活性。在補充有1X GlutaMAXTM (Gibco目錄號35050)、0.1%牛酪蛋白(Sigma C4765-10ML)、250 µM IBMX ( 3-異丁基-1-甲基黃嘌呤，Acros目錄號228420010)及20 mM HEPES (Gibco目錄號15630)之DMEM (Gibco目錄號31053)中，以20 µL分析體積(最終DMSO濃度為0.5%)，用對照多肽或實例1至3中之一者處理表現hGIPR、hGLP-1R或hGCGR受體之細胞(DMSO中之20點濃度反應曲線、2.75倍Labcyte Echo直接稀釋、384孔盤Corning目錄號3570)。實驗亦在相同的分析條件下，在添加1.0%無脂肪酸、無球蛋白之人類血清白蛋白(Sigma目錄號A3782)的情況下進行。
在37℃下培育30分鐘之後，胞內cAMP之所得增加係使用CisBio cAMP Dynamic 2 HTRF分析套組(62AM4PEJ)來定量地測定。簡言之，細胞內之cAMP含量係藉由添加存在於細胞溶解緩衝液(10 µL)中之cAMP-d2結合物，隨後添加亦存在於細胞溶解緩衝液(10 µL)中之抗體抗cAMP-Eu3+ 穴狀化合物來偵測。所得到的競爭性分析在室溫下培育至少60分鐘，且隨後使用具有320 nm之激發光及665 nm及620 nm之發射光的PerkinElmer Envision®儀器來偵測。Envision單元(665 nm/620 nm*10,000發射)與cAMP存在量成反比且使用cAMP標準曲線轉換成nM cAMP/孔。將各孔中產生之cAMP的量(nM)轉換成在人類GIP(1-42)NH2 、hGLP-1(7-36)NH2 或hGCG存在下所觀測到之最大反應的百分比。相對EC50 值及最高百分比(Emax )係藉由使用最大反應百分比相對於所添加之肽濃度的非線性回歸分析，與四參數邏輯斯諦方程式擬合來推導出。
結果：hGIP(1-42)NH2 、hGLP-1(7-36)NH2 、hGCG及實例化合物之功能資料提供於下表2(0.1%牛酪蛋白)及表3(0.1%牛酪蛋白，1.0%人類血清白蛋白)中。
表 2 ： 在 37 ℃ 下 ( 在 0.1% 牛酪蛋白存在下 ) 培育之肽之功能 cAMP 效能 (EC50 ) 及功效 (Emax ) 。
   hGIPRa hGLP-1Ra hGCGRa
實例 EC50 ，nM (SEM，n)b Emax，% ± SEMc EC50 ，nM (SEM，n)b Emax，% ± SEMc EC50 ，nM (SEM，n)b Emax，% ± SEMc
hGIP(1-42)NH2 0.988 (0.0675, 244/246) 100 ± 0.863            
hGLP-1(7-36)NH2       0.315 (0.00999, 400) 106 ± 0.687      
hGCG             1.95 (0.0802, 301) 101 (se=1.13，n=301)
1 0.0145 (0.00159, 5) 90.2 ± 2.82 0.925 (0.101, 5) 97.0 ± 4.47 ＞9950 (n=1/5) ND
6 0.0477 (0.00717, 3) 101 ± 3.61 2.30 (0.212, 3) 105 ± 1.05 ＞9950 (n=1/3) ND
2 0.0154 (0.000643, 5) 93.0 ± 0.813 1.14 (0.0827, 5) 93.1 ± 5.83 ＞9950 (n=1/5) ND
3 0.0133 (0.00186, 3) 95.9 ± 2.95 0.223 (0.0583, 3) 107 ± 2.51 ＞9950 (n=1/3) ND
4 0.00962 (0.000822, 6) 92.9 ± 0.381 0.137 (0.0117, 6) 99.2 ± 1.24 ＞9950 (n=1/6) ND
7 0.00327 (0.000331, 8) 99.5 ± 2.88 0.00676 (0.00104, 8) 95.4 ± 5.03 ＞9950 (n=1/8) ND
8 0.00307 (0.000291, 5) 103 ± 3.48 0.0157 (0.00381, 5) 103 ± 2.63 ＞9950 (n=1/5) ND
5 0.00585 (0.000683, 6) 99.9 ± 0.649 0.0570 (0.0122, 6) 103 ± 4.79 ＞9150 (n=1/6) ND
9 0.0102 (0.000680, 5) 93.6 ± 2.36 0.421 (0.0704, 5) 98.0 ± 4.97 ＞9950 (n=1/5) ND
10 0.0106 (0.00115, 4) 97.9 ± 1.99 0.329 (0.0311, 4) 99.1 ± 4.04 ＞9950 (n=1/4) ND
11 0.0135 (0.00157, 5) 97.7 ± 2.82 0.511 (0.0355, 5) 102 ± 2.11 ＞9950 (n=1/5) ND
12 0.0127 (0.000647, 5) 100.0 ± 3.09 0.423 (0.0365, 5) 105 ± 5.32 ＞9950 (n=1/5) ND
13 0.00597 (0.000599, 6) 99.0 ± 1.77 0.0214 (0.00421, 6) 104 ± 4.07 ＞9950 (n=1/6) ND
14 0.00802 (0.00123, 6) 95.0 ± 2.32 0.0884 (0.00658, 6) 100 ± 3.78 ＞9950 (n=1/6) ND
15 0.0133 (0.00177, 6) 95.9 ± 2.34 0.995 (0.149, 6) 94.3 ± 4.44 ＞9950 (n=1/6) ND
16 0.0113 (0.00240, 6) 101 ± 4.45 0.245 (0.0192, 6) 104 ± 1.61 ＞9950 (n=1/6) ND
17 0.0129 (0.00209, 5) 97.5 ± 5.04 1.57 (0.314, 5) 106 ± 4.38 ＞9950 (n=1/5) ND
18 0.0226 (0.00161, 4) 97.1 ± 3.28 5.06 (0.710, 4) 104 ± 4.11 ＞9950 (n=1/4) ND
19 0.0158 (0.00198, 4) 96.6 ± 2.70 1.34 (0.201, 4) 104 ± 1.72 ＞9950 (n=1/4) ND
20 0.00985 (0.000468, 3) 98.8 ± 3.19 0.552 (0.0748, 3) 103 ± 3.37 ＞9950 (n=1/3) ND
21 0.00347 (0.000301, 4) 102 ± 2.44 0.00655 (0.000594, 4) 106 ± 2.32 ＞9950 (n=1/4) ND
22 0.00656 (0.00118, 4) 102 ± 3.06 0.0153 (0.00165, 4) 98.6 ± 2.87 ＞9950 (n=1/4) ND
23 0.00299 (0.000153, 4) 101 ± 3.70 0.00722 (0.00106, 4) 102 ± 3.01 ＞9950 (n=1/4) ND
24 0.00266 (0.000185, 5) 104 ± 2.75 0.00630 (0.000480, 5) 104 ± 3.48 ＞9950 (n=1/5) ND
25 0.00243 (0.000195, 5) 101 ± 4.03 0.00426 (0.000485, 5) 102 ± 5.06 ＞9950 (n=1/5) ND
26 0.0218 (0.00198, 5) 99.1 ± 0.793 0.0711 (0.00713, 5) 106 ± 4.85 ＞9950 (n=1/5) ND
27 0.116 88.8 2.77 102 ＞9950 ND
28 0.0554 (0.0177, 3) 95.4 ± 1.58 2.65 (0.180, 3) 99.2 ± 4.11 ＞9950 (n=1/3) ND
29 0.00252 (0.000214, 3) 101 ± 3.24 0.00468 (0.000882, 3) 100 ± 6.65 ＞9950 (n=1/3) ND
30 0.0175 (0.00401, 3) 99.3 ± 4.47 2.27 (0.367, 3) 97.8 ± 10.7 ＞9950 (n=1/3) ND
31 0.00157 (0.000662, 2) 100.0 ± 5.25 0.00342 (0.00136, 2) 91.3 ± 16.1 ＞9950 (n=1/2) ND
32 0.002 98.4 0.0063 119 ＞9950 ND
33 0.00957 (0.00110, 3) 97.6 ± 2.45 0.370 (0.0515, 3) 102 ± 4.78 ＞9950 (n=1/3) ND
34 0.0148 (0.00105, 2) 97.4 ± 2.34 1.00 (0.141, 2) 99.6 ± 4.28 ＞9950 (n=1/2) ND
35 0.0162 (0.00309, 3) 97.0 ± 2.32 0.612 (0.125, 3) 107 ± 4.76 ＞9950 (n=1/3) ND
36 0.0185 (0.00551, 3) 95.4 ± 2.02 0.536 (0.0920, 3) 100 ± 3.79 ＞9950 (n=1/3) ND
37 0.0211 (0.0115, 2) 91.2 ± 3.67 0.909 (0.0795, 3) 105 ± 3.13 ＞9950 (n=1/3) ND
38 0.0155 (0.00104, 3) 99.7 ± 1.92 0.225 (0.0142, 3) 106 ± 1.38 ＞9950 (n=1/3) ND
39 0.0238 (0.00641, 3) 96.5 ± 1.44 0.358 (0.0311, 3) 105 ± 6.57 ＞9950 (n=1/3) ND
40 0.0116 (0.00653, 2) 99.7 ± 2.94 0.279 (0.0725, 2) 101 ± 5.30 ＞9950 (n=1/2) ND
41 0.0108 (0.000456, 2) 101 ± 3.16 0.691 (0.0736, 2) 102 ± 3.70 ＞9950 (n=1/2) ND
42 0.0103 (0.00133, 2) 97.8 ± 7.18 0.429 (0.0612, 2) 104 ± 1.38 ＞9950 (n=1/2) ND
43 0.0123 (0.00510, 2) 92.6 ± 5.56 0.821 (0.00670, 2) 106 ± 2.02 ＞9950 (n=1/2) ND
44 0.0637 (0.0744, 2) 92.2 ± 6.17 4.77 (0.859, 2) 90.9 ± 10.4 ＞9950 (n=1/2) ND
45 0.0517 (0.0654, 2) 91.3 ± 1.04 9.18 (5.30, 2) 85.7 ± 8.37 ＞9950 (n=1/2) ND
46 0.0801 (0.0992, 2) 89.5 ± 2.64 3.29 (1.49, 2) 79.2 ± 1.23 ＞9950 (n=1/2) ND
47 0.0138 (0.00357, 2) 89.8 ± 1.20 1.94 (4.03, 2) 87.1 ± 14.1 ＞9950 (n=1/2) ND
48 0.0182 (0.00262, 2) 91.6 ± 3.38 1.000 (1.43, 2) 87.8 ± 6.25 ＞9950 (n=1/2) ND
49 0.0205 (0.00423, 5) 91.0 ± 1.70 0.398 (0.0572, 5) 97.3 ± 5.46 ＞9950 (n=1/5) ND
50 0.0168 (0.00162, 4) 94.7 ± 1.77 0.273 (0.0222, 4) 101 ± 6.20 ＞9950 (n=1/4) ND
51 0.110 (0.0153, 2) 101 ± 0.990 0.890 (0.0286, 2) 85.7 ± 9.80 ＞9950 (n=1/2) ND
52 0.258 (0.00726, 2) 104 ± 1.25 0.384 (0.116, 2) 84.3 ± 6.96 ＞9950 (n=1/2) ND
53 0.0841 (0.0165, 4) 99.6 ± 2.21 0.180 (0.0157, 4) 89.9 ± 9.41 ＞9950 (n=1/4) ND
54 0.0675 113 0.538 101 ＞9950 ND
55 0.0207 (0.00345, 4) 97.1 ± 2.16 0.154 (0.0278, 4) 108 ± 1.94 ＞9950 (n=1/4) ND
56 0.0138 (0.00215, 4) 90.3 ± 2.57 0.205 (0.0208, 4) 106 ± 4.02 ＞9950 (n=1/4) ND
57 0.0135 (0.00176, 3) 91.5 ± 4.94 0.140 (0.0119, 3) 102 ± 2.52 ＞9950 (n=1/3) ND
58 0.0158 (0.00284, 3) 89.2 ± 5.96 0.194 (0.0220, 3) 101 ± 5.94 ＞9950 (n=1/3) ND
59 0.0240 (0.00529, 3) 89.2 ± 4.62 0.202 (0.0167, 3) 107 ± 4.27 ＞9950 (n=1/3) ND
60 0.0126 (0.00263, 3) 94.0 ± 6.07 0.190 (0.0132, 3) 97.2 ± 4.28 ＞9950 (n=1/3) ND
61 0.012 88.2 1.35 82.9 ＞9950 ND
62 0.0211 (0.00397, 3) 96.1 ± 2.64 0.480 (0.0200, 3) 99.4 ± 5.83 ＞9950 (n=1/3) ND
63 0.0176 92.7 1.86 90.6 ＞9950 ND
64 0.0158 (0.00140, 3) 92.9 ± 3.06 0.557 (0.0434, 3) 97.3 ± 4.13 ＞9950 (n=1/3) ND
65 0.0139 (0.00208, 3) 95.2 ± 2.93 0.300 (0.0590, 3) 103 ± 0.751 ＞9950 (n=1/3) ND
66 0.0168 (0.00351, 3) 93.5 ± 1.39 0.355 (0.0103, 3) 104 ± 1.78 ＞9950 (n=1/3) ND
67 0.00795 95 2.63 91.7 ＞9950 ND
68 0.0105 106 0.668 95.9 ＞9950 ND
69 0.0265 (0.00500, 3) 99.0 ± 2.43 0.276 (0.00951, 4) 103 ± 1.65 ＞9950 (n=1/4) ND
70 0.0182 (0.00101, 4) 89.1 ± 2.30 0.283 (0.0345, 5) 100.0 ± 3.11 ＞9950 (n=1/5) ND
71 0.0171 (0.00174, 3) 93.8 ± 3.59 0.246 (0.0242, 4) 106 ± 1.60 ＞9950 (n=1/4) ND
72 0.0160 (0.00172, 3) 96.5 ± 3.71 0.245 (0.0271, 4) 103 ± 3.06 ＞9950 (n=1/4) ND
73 0.0207 (0.00350, 4) 97.1 ± 2.70 0.437 (0.0687, 4) 99.2 ± 1.69 ＞9950 (n=1/4) ND
74 0.0156 (0.00216, 3) 93.3 ± 2.89 0.334 (0.0383, 4) 105 ± 3.28 ＞9950 (n=1/4) ND
75 0.0182 (0.00258, 4) 92.3 ± 0.780 0.411 (0.0467, 5) 104 ± 4.00 ＞9950 (n=1/5) ND
76 0.0205 (0.00391, 4) 102 ± 3.22 0.527 (0.0914, 4) 93.5 ± 1.85 ＞9950 (n=1/4) ND
77 0.0288 (0.00467, 3) 94.8 ± 2.69 3.03 (0.922, 3) 87.0 ± 1.71 ＞9950 (n=1/3) ND
78 0.0145 (0.00447, 4) 101 ± 2.27 0.286 (0.0619, 4) 100 ± 2.19 ＞9950 (n=1/4) ND
79 0.0130 (0.00567, 2) 101 ± 0.395 0.223 (0.0242, 2) 102 ± 1.09 ＞9950 (n=1/2) ND
80 0.0245 (0.00347, 4) 92.4 ± 1.14 0.718 (0.155, 4) 102 ± 4.87 ＞9950 (n=1/4) ND
81 0.0114 (0.00273, 2) 98.6 ± 6.19 0.176 (0.0351, 2) 102 ± 3.94 ＞9950 (n=1/2) ND
82 0.0206 (0.00375, 2) 81.4 ± 6.09 4.78 (1.32, 2) 103 ± 1.82 ＞9950 (n=1/2) ND
83 0.0223 (0.00261, 2) 89.6 ± 7.35 0.451 (0.0979, 2) 103 ± 4.98 ＞9950 (n=1/2) ND
84 0.0315 98.5 5.27 94 ＞9950 ND
85 0.0312 91.7 7.69 95.3 ＞9950 ND
86 0.0184 (0.00461, 2) 94.2 ± 1.16 0.359 (0.0267, 2) 103 ± 1.21 ＞9950 (n=1/2) ND
87 0.029 84.7 1.34 106 ＞9950 ND
88 0.00884 85.1 6.08 97.1 ＞9950 ND
89 0.0301 (0.00853, 2) 88.9 ± 3.76 1.03 (0.293, 2) 105 ± 2.00 ＞9950 (n=1/2) ND
90 0.0436 (0.0112, 3) 93.0 ± 3.31 0.221 (0.0317, 3) 96.2 ± 1.50 ＞9950 (n=1/3) ND
91 0.0739 (0.0337, 3) 92.8 ± 4.69 0.153 (0.0297, 3) 94.0 ± 5.44 ＞9950 (n=1/3) ND
92 0.0251 (0.0114, 2) 104 ± 4.05 0.942 (0.0878, 2) 105 ± 2.61 ＞9950 (n=1/2) ND
93 0.0448 (0.0197, 2) 99.4 ± 6.93 0.575 (0.0808, 2) 106 ± 1.59 ＞9950 (n=1/2) ND
94 0.0132 91 2.1 97.4 ＞9950 ND
95 0.0748 97.3 0.181 86.9 ＞9950 ND
96 0.0484 107 6.81 103 ＞9950 ND
97 0.0276 (0.00391, 3) 97.0 ± 1.53 0.683 (0.124, 3) 96.6 ± 1.60 ＞9950 (n=1/3) ND
98 0.0148 (0.00572, 3) 97.7 ± 2.54 0.227 (0.0401, 3) 98.6 ± 4.62 ＞9950 (n=1/3) ND
99 0.0235 (0.00111, 2) 93.4 ± 1.02 0.349 (0.114, 3) 99.1 ± 4.31 ＞9950 (n=1/3) ND
100       11.4 111 ＞9950 ND
101 0.0297 92.1 2.94 106 ＞9950 ND
102       19.1 93.7 ＞9950 ND
103 0.0305 92.8 2.10 (0.127, 2) 106 ± 0.389 ＞9950 (n=1/2) ND
104 0.0361 94.9 0.417 (0.00529, 2) 107 ± 1.35 ＞9950 (n=1/2) ND
105 0.0366 (0.00225, 3) 103 ± 4.03 0.520 (0.0485, 3) 105 ± 1.91 ＞9950 (n=1/3) ND
106 0.0385 (0.00452, 3) 98.7 ± 3.32 0.296 (0.0390, 3) 103 ± 2.32 ＞9950 (n=1/3) ND
107 0.0473 94.3 1.01 93.4 ＞9950 ND
108 0.0249 85.2 0.701 97.6 ＞9950 ND
109 0.0236 84.8 0.846 102 ＞9950 ND
110 0.0417 106 1.43 98.8 ＞9950 ND
111 0.0202 76.1 2.28 121 ＞9950 ND
112 0.0229 93.6 2.26 107 ＞9950 ND
113 0.0331 (0.00385, 3) 97.9 ± 3.21 0.291 (0.0242, 3) 101 ± 0.880 ＞9950 (n=1/3) ND
114 0.0613 93.8 0.176 91.7 ＞9950 ND
115 0.103 105 0.16 91.6 ＞9950 ND
116 0.137 115 0.197 99.3 ＞9950 ND
117 0.0352 96.4 5.6 98.2 ＞9950 ND
118 0.0547 94.7 0.437 103 ＞9950 ND
119 0.0863 103 0.351 99.4 ＞9950 ND
120 0.0866 105 1.43 102 ＞9950 ND
121 0.0271 92.8 8.95 106 ＞9950 ND
122 0.064 105 0.41 94.3 ＞9950 ND
123 0.101 94.9 0.508 96.3 ＞9950 ND
124 0.1 102 1.24 93.3 ＞9950 ND
125 0.0547 94.4 2.78 103 ＞9950 ND
126 0.0472 91.8 1.69 101 ＞9950 ND
127 0.027 99.3 0.762 98.5 ＞9950 ND
128 0.0232 (0.000862, 3) 98.5 ± 2.47 0.293 (0.0278, 3) 98.4 ± 4.78 ＞9950 (n=1/3) ND
129 0.0248 100 1.28 97.9 ＞9950 ND
130 0.0266 (0.00252, 3) 94.7 ± 4.51 0.204 (0.0158, 3) 100 ± 1.69 ＞9950 (n=1/3) ND
131 0.0156 (0.000742, 5) 96.4 ± 1.95 0.190 (0.0152, 6) 101 ± 2.01 ＞9950 (n=1/6) ND
132 0.0208 (0.00119, 4) 98.3 ± 1.68 0.182 (0.0131, 4) 102 ± 3.32 ＞9950 (n=1/4) ND
133 0.0180 (0.00101, 5) 92.7 ± 2.84 0.258 (0.0246, 6) 101 ± 0.993 ＞9950 (n=1/5) ND
134 0.0238 (0.00167, 3) 99.2 ± 3.29 0.577 (0.0669, 3) 106 ± 6.27 ＞9950 (n=1/3) ND
135 0.0184 (0.00169, 4) 92.3 ± 2.64 0.271 (0.00688, 5) 98.4 ± 1.80 ＞9950 (n=1/4) ND
136 0.00690 (0.000974, 3) 97.4 ± 4.23 0.0918 (0.0102, 3) 107 ± 4.14 ＞9950 (n=1/3) ND
137 0.0116 (0.00151, 3) 105 ± 3.73 0.134 (0.0126, 4) 99.0 ± 4.03 ＞9950 (n=1/4) ND
138 0.0197 (0.00311, 3) 104 ± 2.12 0.267 (0.0474, 3) 101 ± 2.93 ＞9950 (n=1/3) ND
139 0.0108 99.3 0.141 111 ＞9950 ND
140 0.0121 (0.000610, 3) 98.5 ± 1.71 0.131 (0.00335, 3) 106 ± 5.31 ＞9950 (n=1/3) ND
141 0.00723 (0.000819, 3) 98.8 ± 1.09 0.0693 (0.00248, 4) 102 ± 2.84 ＞9950 (n=1/4) ND
142 0.0317 (0.00486, 2) 98.6 ± 5.71 0.322 (0.0246, 2) 103 ± 6.70 ＞9950 (n=1/2) ND
143 0.022 95 0.512 103 ＞9950 ND
144 0.0193 90 3.47 97 ＞9950 ND
145 0.0286 74.8 0.555 95.1 ＞9950 ND
146 0.0198 76.5 0.688 108 ＞9950 ND
147 0.0229 98.6 0.338 93.5 ＞9950 ND
148 0.0209 98.4 1.77 94.5 ＞9950 ND
149 0.0791 (0.00155, 2) 104 ± 0.229 1.50 (0.0754, 2) 98.3 ± 0.579 ＞9950 (n=1/2) ND
150 0.0268 (0.00212, 3) 104 ± 6.96 0.455 (0.0582, 4) 99.8 ± 3.10 ＞9950 (n=1/4) ND
151 0.0197 (0.00252, 3) 99.9 ± 4.41 0.546 (0.0892, 4) 102 ± 4.57 ＞9950 (n=1/4) ND
152 0.0416 (0.000338, 2) 97.9 ± 3.25 3.91 (0.457, 2) 102 ± 7.89 ＞9950 (n=1/2) ND
153 0.0277 (0.00197, 2) 97.8 ± 2.74 1.10 (0.248, 3) 91.8 ± 4.63 ＞9950 (n=1/3) ND
154 0.0299 (0.00189, 2) 96.6 ± 3.26 1.69 (0.354, 3) 102 ± 4.07 ＞9950 (n=1/2) ND
155 0.0309 (0.00849, 2) 96.6 ± 7.55 0.912 (0.163, 3) 99.0 ± 5.16 ＞9950 (n=1/2) ND
156 0.0422 89.9 4.6 110 ＞9950 ND
157 0.0286 (0.000896, 2) 98.8 ± 1.33 0.940 (0.206, 3) 98.5 ± 4.73 ＞9950 (n=1/3) ND
158 0.0204 93.4 0.448 87.2 ＞9950 ND
159 0.0198 95.3 0.558 89.4 ＞9950 ND
160 0.0197 101 0.228 93.6 ＞9950 ND
161 0.0207 (0.00167, 3) 94.6 ± 1.21 0.203 (0.00545, 3) 107 ± 5.29 ＞9950 (n=1/3) ND
162 0.022 89.7 0.327 99 ＞9950 ND
163 0.0427 98.2 0.199 86.3 ＞9950 ND
164 0.0464 (0.00253, 2) 95.8 ± 5.48 0.236 (0.00998, 2) 93.8 ± 0.298 ＞9950 (n=1/2) ND
165 0.0442 96.1 0.291 94.3 ＞9950 ND
166 0.0774 97 0.192 90.3 ＞9950 ND
167 0.0534 (0.0163, 2) 99.5 ± 6.17 0.217 (0.00420, 2) 91.4 ± 3.21 ＞9950 (n=1/2) ND
168 0.0482 93 0.312 93.3 ＞9950 ND
169 0.0381 96.1 1.23 100 ＞9950 ND
170 0.0244 93.9 1.03 104 ＞9950 ND
171 0.0389 95.3 1.7 99.7 ＞9950 ND
172 0.0149 (0.000516, 2) 89.9 ± 1.05 0.141 (0.0138, 3) 99.8 ± 2.93 ＞9950 (n=1/3) ND
173 0.0155 (0.00731, 2) 87.8 ± 6.22 0.343 (0.0897, 3) 89.9 ± 2.72 ＞9950 (n=1/3) ND
174 0.0284 92.2 0.33 98.2 ＞9950 ND
175 0.0337 100 0.227 91.1 ＞9950 ND
176 0.0485 89.3 0.298 98.9 ＞9950 ND
177 0.0433 113 0.178 101 ＞9950 ND
178 0.11 105 0.22 102 ＞9950 ND
179 0.15 91 0.461 99 ＞9950 ND
180 0.224 86.8 0.26 99.5 ＞9950 ND
181 0.154 94.6 0.182 101 ＞9950 ND
182 0.368 89 0.185 96.9 ＞9950 ND
183 0.0326 (0.000430, 2) 93.5 ± 1.46 1.37 (0.273, 2) 93.9 ± 4.99 ＞9950 (n=1/2) ND
184 0.0354 (0.00396, 2) 95.2 ± 1.13 1.82 (0.135, 2) 96.8 ± 12.0 ＞9950 (n=1/2) ND
185 0.0180 (0.00136, 2) 94.5 ± 0.288 0.419 (0.0758, 2) 95.1 ± 1.74 ＞9950 (n=1/2) ND
186 0.0274 (0.00339, 2) 92.7 ± 0.689 0.371 (0.0267, 2) 102 ± 5.53 ＞9950 (n=1/2) ND
187 0.0260 (0.00396, 3) 101 ± 2.77 0.386 (0.0467, 3) 102 ± 7.10 ＞9950 (n=1/3) ND
188 0.0228 (0.00116, 2) 94.9 ± 1.49 0.332 (0.0557, 2) 96.6 ± 4.28 ＞9950 (n=1/2) ND
189 0.0202 (0.00407, 2) 96.6 ± 4.38 0.280 (0.0253, 2) 100 ± 3.68 ＞9950 (n=1/2) ND
190 0.0240 (0.00181, 2) 94.5 ± 0.611 0.303 (0.0624, 3) 98.9 ± 4.64 ＞9950 (n=1/3) ND
191 0.0601 (0.00698, 2) 90.0 ± 3.29 0.926 (0.0435, 3) 98.6 ± 5.09 ＞9950 (n=1/3) ND
192 0.0375 (0.00284, 4) 96.5 ± 4.86 0.518 (0.0340, 5) 100 ± 2.34 ＞9950 (n=1/5) ND
193 0.0201 (0.0000166, 2) 97.2 ± 4.63 0.382 (0.0862, 3) 104 ± 3.84 ＞9950 (n=1/3) ND
194 0.0233 (0.00272, 2) 93.1 ± 1.05 0.317 (0.0737, 3) 103 ± 2.96 ＞9950 (n=1/2) ND
195 0.0219 (0.000744, 2) 88.5 ± 4.32 0.343 (0.0430, 3) 101 ± 5.39 ＞9950 (n=1/3) ND
196 0.0232 (0.00120, 4) 96.0 ± 2.10 0.356 (0.0387, 5) 96.8 ± 2.59 ＞9950 (n=1/5) ND
197 0.0338 (0.00123, 3) 102 ± 1.85 0.336 (0.0398, 4) 103 ± 3.66 ＞9950 (n=1/4) ND
198 0.0269 (0.000614, 3) 94.0 ± 1.17 0.362 (0.0292, 4) 102 ± 2.25 ＞9950 (n=1/4) ND
199 0.0587 (0.00741, 2) 96.9 ± 1.48 3.20 (1.31, 2) 96.7 ± 6.69 ＞9950 (n=1/2) ND
200 0.0503 (0.00678, 2) 96.3 ± 2.76 0.834 (0.287, 2) 93.7 ± 2.72 ＞9950 (n=1/2) ND
201 0.188 (0.0191, 2) 92.2 ± 3.26 0.487 (0.143, 2) 105 ± 4.51 ＞9950 (n=1/2) ND
202 0.057 86 0.944 92.2 ＞9950 ND
203 0.0721 106 0.535 119 ＞9950 ND
204 0.0304 99.3 0.47 126 ＞9950 ND
205 0.0264 101 0.287 99.6 ＞9950 ND
206 0.0204 96.4 0.299 100 ＞9950 ND
207 0.019 96.2 0.209 95.1 ＞9950 ND
208 0.018 94.9 0.238 101 ＞9950 ND
209 0.0133 92.7 0.235 100 ＞9950 ND
210 0.02 92.1 0.57 102 ＞9950 ND
211 0.0465 91.6 3.55 93.1 ＞9950 ND
212 0.0385 100 0.265 94.7 ＞9950 ND
213 0.0275 92 2.14 94.8 ＞9950 ND
214 0.0351 93.7 0.618 93.2 ＞9950 ND
215 0.0437 85 0.44 89.8 ＞9950 ND
216 0.0287 88.5 0.384 93.6 ＞9950 ND
217 0.0309 95.5 0.436 88 ＞9950 ND
218 0.0515 90.2 0.714 92.6 ＞9950 ND
219 0.0227 (0.00409, 3) 96.7 (2.65, 3) 0.376 (0.0133, 3) 103 (6.04, 3) ＞9950 (n=1/3) ND
220 0.0237 91.6 0.535 87.6 ＞9950 ND
221 0.0279 81.8 1.83 83 ＞9950 ND
222 0.0195 98.7 0.518 91.6 ＞9950 ND
223 0.0252 103 1.43 94 ＞9950 ND
224 0.0374 109 7.51 88.4 ＞9950 ND
225 0.0466 105 9.62 92.1 ＞9950 ND
226 0.0232 101 0.611 101 ＞9950 ND
227 0.0224 103 1.22 96.1 ＞9950 ND
228 0.0232 110 1.34 91.1 ＞9950 ND
229 0.0253 103 2.25 94.3 ＞9950 ND
230 0.0199 (0.00457, 2) 105 (4.33, 2) 0.726 (0.336, 2) 90.3 (7.27, 2) ＞9950 (n=1/2) ND
231 0.0184 (0.000100, 2) 102 (3.90, 2) 1.22 (0.624, 2) 107 (0.639, 2) ＞9950 (n=1/2) ND
232 0.0192 101 0.565 103 ＞9950 ND
233 0.0269 (0.00700, 2) 105 (2.26, 2) 0.604 (0.378, 2) 111 (1.51, 2) ＞9950 (n=1/2) ND
234 0.0182 107 0.319 112 ＞9950 ND
235 0.0168 99.3 0.295 104 ＞9950 ND
236 0.0154 (0.000744, 2) 104 (0.0421, 2) 0.336 (0.103, 2) 96.5 (2.64, 2) ＞9950 (n=1/2) ND
237 0.0186 (0.00115, 2) 102 (0.313, 2) 0.633 (0.0615, 2) 102 (2.05, 2) ＞9950 (n=1/2) ND
238 0.0214 (0.00134, 2) 104 (0.833, 2) 1.03 (0.378, 2) 107 (1.17, 2) ＞9950 (n=1/2) ND
239 0.0328 (0.00506, 2) 104 (5.23, 2) 0.546 (0.0853, 2) 101 (4.97, 2) ＞9950 (n=1/2) ND
240 0.0237 (0.000808, 2) 99.1 (1.18, 2) 0.508 (0.151, 2) 98.5 (11.5, 2) ＞9950 (n=1/2) ND
241 0.0213 (0.0000794, 2) 105 (0.357, 2) 0.362 (0.0106, 2) 91.0 (16.3, 2) ＞9950 (n=1/2) ND
242 0.0197 (0.00163, 2) 100 (8.54, 2) 0.584 (0.134, 2) 96.3 (3.81, 2) ＞9950 (n=1/2) ND
243 0.0154 (0.00300, 3) 101 (6.26, 3) 0.860 (0.294, 3) 93.2 (4.52, 3) ＞9950 (n=1/3) ND
244 0.0218 (0.00545, 3) 101 (3.95, 3) 2.25 (1.04, 3) 104 (3.83, 3) ＞9950 (n=1/3) ND
245 0.0195 (0.00407, 3) 96.7 (3.74, 3) 1.88 (0.824, 3) 88.9 (8.09, 3) ＞9950 (n=1/3) ND
246 0.0223 (0.00101, 4) 96.9 (2.89, 4) 0.441 (0.0598, 4) 102 (1.52, 4) ＞9950 (n=1/4) ND
247 0.0220 (0.000585, 2) 103 (1.70, 2) 1.00 (0.641, 2) 108 (0.981, 2) ＞9950 (n=1/2) ND
248 0.0176 (0.00189, 2) 99.2 (1.51, 2) 0.537 (0.130, 2) 89.1 (7.08, 2) ＞9950 (n=1/2) ND
249 0.0201 108 0.300 (0.0349, 2) 101 (6.23, 2) ＞9950 ND
250 0.021 102 0.414 (0.126, 2) 114 (4.93, 2) ＞9950 ND
251 0.0305 107 0.338 (0.0109, 2) 99.0 (7.31, 2) ＞9950 ND
252 0.049 109 0.555 (0.102, 2) 115 (4.34, 2) ＞9950 ND
253 0.0295 (0.00329, 2) 101 (3.43, 2) 0.430 (0.0422, 2) 113 (3.67, 2) ＞9950 (n=1/2) ND
254 0.0273 (0.000844, 2) 98.2 (5.88, 2) 0.507 (0.101, 2) 103 (4.62, 2) ＞9950 (n=1/2) ND
255 0.0213 103 0.357 103 ＞9950 ND
256 0.0175 97.7 0.249 95.4 ＞9950 ND
257 0.148 90.3 2.03 82 ＞9950 ND
258 0.0473 90.3 0.653 94.9 ＞9950 ND
259 0.0198 111 0.362 (0.0362, 2) 99.5 (5.41, 2) ＞9950 ND
260 0.0239 113 0.547 (0.0453, 2) 108 (2.42, 2) ＞9950 ND
261 0.025 105 0.531 (0.00408, 2) 97.9 (1.27, 2) ＞9950 ND
262 0.0327 89.8 0.472 (0.00490, 2) 105 (5.10, 2) ＞9950 ND
263 0.0214 88.6 0.294 (0.000357, 2) 98.5 (5.68, 2) ＞9950 ND
264 0.0208 114 0.413 (0.0548, 2) 113 (1.32, 2) ＞9950 ND
265 0.0145 (0.000696, 2) 100 (1.69, 2) 0.262 (0.0581, 2) 99.8 (5.27, 2) ＞9950 (n=1/2) ND
266 0.0136 (0.0000240, 2) 93.2 (8.75, 2) 0.282 (0.0352, 2) 90.5 (17.9, 2) ＞9950 (n=1/2) ND
267 0.0162 (0.000222, 2) 104 (6.11, 2) 0.271 (0.0367, 2) 103 (0.674, 2) ＞9950 (n=1/2) ND
268 0.0265 102 0.613 112 ＞9950 ND
269 0.0335 (0.00245, 2) 95.3 (4.18, 2) 1.72 (1.17, 2) 96.5 (7.69, 2) ＞9950 (n=1/2) ND
270 0.0567 91.7 0.551 97 ＞9950 ND
271 0.0186 98.6 0.494 101 ＞9950 ND
272 0.0264 86 0.388 99.9 ＞9950 ND
273 0.0166 100 2.08 103 ＞9950 ND
274 0.0226 103 0.406 114 ＞9950 ND
275 0.0152 104 0.737 110 ＞9950 ND
276 0.0134 102 0.49 103 ＞9950 ND
277 0.0176 (0.000579, 2) 107 (2.27, 2) 0.225 (0.0241, 2) 97.1 (0.819, 2) ＞9950 (n=1/2) ND
278 0.0173 (0.000584, 2) 105 (0.0609, 2) 0.290 (0.0314, 2) 109 (3.42, 2) ＞9950 (n=1/2) ND
279 0.0305 103 0.406 112 ＞9950 ND
280 0.0229 105 0.346 106 ＞9950 ND
281 0.0187 110 0.252 100 ＞9950 ND
282 0.0193 100 0.216 97.1 ＞9950 ND
283 0.073 107 1.14 108 ＞9950 ND
284 0.0389 98.3 0.505 110 ＞9950 ND
285 0.0115 101 1.21 102 ＞9950 ND
286 0.0344 108 0.678 110 ＞9950 ND
287 0.0189 93 0.563 97.2 ＞9950 ND
288 0.0219 110 0.354 103 ＞9950 ND
289 0.017 111 0.731 96.7 ＞9950 ND
290 0.0188 103 0.324 101 ＞9950 ND
291 0.012 99.6 0.207 97.6 ＞9950 ND
292 0.00620 (0.000221, 5) 101 (2.00, 5) 0.0758 (0.00345, 5) 104 (1.25, 5) ＞9950 (n=1/5) ND
293 0.00915 (0.00192, 3) 102 (0.983, 3) 0.102 (0.00688, 3) 102 (1.78, 3) ＞9950 (se=20.5, n=2/3) ND
294 0.00615 105 0.0665 106 ＞9950 ND
295 0.0141 104 0.167 109 ＞9950 ND
296 0.0121 100 0.108 109 ＞9950 ND
297 0.0112 103 0.125 108 ＞9950 ND
298 0.0107 (0.00103, 3) 97.4 (2.75, 3) 0.190 (0.0493, 3) 106 (2.35, 3) ＞9950 (n=1/3) ND
299 0.0104 (0.00202, 3) 101 (4.84, 3) 0.126 (0.0217, 3) 103 (3.15, 3) ＞9950 (n=1/3) ND
300 0.0128 (0.000753, 3) 102 (1.14, 3) 0.194 (0.00146, 3) 107 (2.29, 3) ＞9950 (n=1/3) ND
301 0.0128 (0.000550, 2) 97.4 (2.71, 2) 0.175 (0.0218, 2) 99.2 (3.94, 2) ＞9950 (n=1/2) ND
302 0.00916 (0.00192, 2) 100 (2.39, 2) 0.0917 (0.00850, 2) 103 (0.561, 2) ＞9950 (n=1/2) ND
303 0.0178 100 0.389 102 ＞9950 ND
304 0.047 110 0.474 101 ＞9950 ND
305 0.0289 105 0.629 92.7 ＞9950 ND
306 0.0227 102 0.414 105 ＞9950 ND
307 0.0292 105 0.376 101 ＞9950 ND
308 0.0551 117 0.689 98 ＞9950 ND
309 0.0212 107 0.527 104 ＞9950 ND
310 0.0250 (0.00750, 2) 99.9 (0.909, 2) 0.347 (0.00203, 2) 105 (1.16, 2) ＞9950 (n=1/2) ND
311 0.0243 105 0.791 110 ＞9950 ND
312 0.00757 105 0.663 104 ＞9950 ND
313 0.00781 101 1.13 98.6 ＞9950 ND
314 0.0216 100 0.673 104 ＞9950 ND
315 0.0245 (0.000567, 2) 108 (2.95, 2) 0.376 (0.0331, 2) 98.9 (6.60, 2) ＞9950 (n=1/2) ND
316 0.0316 (0.00498, 2) 103 (2.75, 2) 0.571 (0.0402, 2) 109 (0.715, 2) ＞9950 (n=1/2) ND
317 0.0587 112 1.34 101 ＞9950 (n=1/2) ND
318 0.0402 (0.0122, 3) 106 (5.44, 3) 0.219 (0.00541, 3) 99.9 (2.22, 3) ＞9950 (n=1/3) ND
319 0.0196 (0.00610, 3) 98.1 (2.58, 3) 0.180 (0.00678, 2) 100 (4.36, 2) ＞9950 (n=1/3) ND
320 0.0144 (0.00517, 2) 94.2 (0.879, 2) 0.246 (0.0335, 2) 101 (5.01, 2) ＞9950 (n=1/2) ND
321 0.0107 (0.00388, 2) 108 (0.116, 2) 0.295 (0.0332, 2) 102 (1.81, 2) ＞9950 (n=1/2) ND
322 0.00937 (0.00109, 6) 101 (1.47, 6) 0.144 (0.0108, 6) 100 (1.87, 6) ＞9950 (n=1/6) ND
323 0.00793 101 0.203 92.6 ＞9950 ND
324 0.00632 (0.000630, 6) 101 (2.01, 6) 0.0647 (0.00427, 6) 97.6 (3.15, 6) ＞9950 (n=1/6) ND
325 0.0485 (0.0145, 3) 104 (1.22, 3) 0.225 (0.0687, 3) 97.8 (1.80, 3) ＞9950 (n=1/3) ND
326 0.0338 (0.0137, 3) 102 (3.35, 3) 0.186 (0.00851, 3) 94.4 (4.49, 3) ＞9950 (n=1/3) ND
327 0.0180 (0.00855, 2) 105 (2.94, 2) 0.211 (0.0578, 2) 105 (1.05, 2) ＞9950 (n=1/2) ND
328 0.00973 106 0.405 99.6 ＞9950 ND
329 0.015 109 0.353 104 ＞9950 ND
330 0.0185 112 0.477 103 ＞9950 ND
331 0.0113 101 0.436 99.6 ＞9950 ND
332 0.0109 107 0.263 114 ＞9950 ND
333 0.0062 109 0.388 107 ＞9950 ND
334 0.00987 (0.00114, 6) 103 (2.09, 6) 0.131 (0.0111, 6) 104 (2.98, 6) ＞9950 (n=1/6) ND
335 0.00871 107 0.175 113 ＞9950 ND
336 0.0136 (0.00163, 4) 109 (3.29, 4) 0.338 (0.0360, 4) 107 (4.12, 4) ＞10100 (n=1/4) ND
337 0.0151 (0.00142, 4) 103 (4.79, 4) 0.444 (0.0734, 4) 107 (3.72, 4) ＞10100 (n=1/4) ND
338 0.0157 (0.000927, 4) 104 (2.93, 4) 0.468 (0.0280, 4) 109 (4.09, 4) ＞10100 (n=1/4) ND
339 0.0190 (0.00238, 4) 106 (3.70, 4) 0.308 (0.0377, 4) 113 (6.21, 4) ＞10100 (n=1/4) ND
340 0.0206 95.2 0.409 105 ＞9950 ND
341 0.0127 (0.00156, 2) 91.4 (2.36, 2) 0.329 (0.00763, 2) 99.9 (1.08, 2) ＞9950 (n=1/2) ND
342 0.0105 (0.000707, 4) 106 (4.47, 4) 0.191 (0.0245, 4) 113 (5.23, 4) ＞10100 (n=1/4) ND
343 0.0111 98.8 0.275 104 ＞9950 ND
344 0.0174 97.9 0.336 100 ＞9950 ND
345 0.0147 (0.000586, 2) 98.9 (1.25, 2) 0.285 (0.0205, 2) 105 (3.05, 2) ＞9950 (n=1/2) ND
346 0.0194 96.6 0.329 107 ＞9950 ND
347 0.0259 98 0.356 103 ＞9950 ND
348 0.0228 95.9 0.805 99.9 ＞9950 ND
349 0.015 95.9 0.334 99 ＞9950 ND
350 0.0288 101 0.202 95.9 ＞9950 ND
351 0.0185 102 0.397 100 ＞9950 ND
352 0.0106 98.3 0.262 99.5 ＞9950 ND
353 0.0249 98.2 0.203 98 ＞9950 ND
354 0.0249 95.4 0.505 99.9 ＞9950 ND
355 0.0365 101 0.574 105 ＞9950 ND
356 0.0488 96.2 0.936 101 ＞9950 ND
357 0.0110 (0.00125, 4) 99.9 (5.05, 4) 0.649 (0.130, 4) 107 (2.67, 4) ＞10100 (n=1/4) ND
358 0.0137 (0.000651, 4) 99.6 (4.03, 4) 0.773 (0.119, 4) 107 (3.82, 4) ＞10100 (n=1/4) ND
359 0.0261 (0.00304, 4) 103 (4.28, 4) 1.18 (0.164, 4) 104 (5.15, 4) ＞10100 (n=1/4) ND
360 0.0121 (0.00106, 2) 106 (1.70, 2) 0.301 (0.0234, 2) 89.8 (0.316, 2) ＞9950 (n=1/2) ND
361 0.0121 (0.00279, 2) 107 (0.508, 2) 0.580 (0.0801, 2) 98.2 (2.23, 2) ＞9950 (n=1/2) ND
362 0.0131 (0.000845, 4) 107 (1.67, 4) 0.340 (0.0419, 4) 109 (2.00, 4) ＞10100 (n=1/4) ND
363 0.0183 111 0.34 108 ＞9950 ND
364 0.0111 101 0.347 107 ＞9950 ND
365 0.00809 105 0.362 98.5 ＞9950 ND
366 0.0162 (0.00214, 2) 108 (3.61, 2) 0.279 (0.0415, 2) 89.6 (8.49, 2) ＞9950 (n=1/2) ND
367 0.019 112 0.366 93.9 ＞9950 ND
368 0.0271 105 0.411 103 ＞9950 ND
369 0.037 102 0.555 99.1 ＞9950 ND
370 0.0282 105 0.402 112 ＞9950 ND
371 0.0209 102 0.363 112 ＞9950 ND
372 0.0112 97.3 0.291 108 ＞9950 ND
373 0.0152 101 0.329 101 ＞9950 ND
374 0.0135 96.2 0.269 106 ＞9950 ND
375 0.0566 100 1.11 106 ＞9950 ND
376 0.0281 99.8 0.539 104 ＞9950 ND
377 0.0205 92.8 0.356 100 ＞9950 ND
378 0.0132 (0.00169, 2) 93.5 (2.41, 2) 0.166 (0.00187, 2) 98.9 (2.96, 2) ＞9950 (n=1/2) ND
379 0.0167 (0.00194, 2) 97.5 (1.50, 2) 0.171 (0.0104, 2) 104 (5.78, 2) ＞9950 (n=1/2) ND
380 0.0209 (0.00237, 2) 100 (3.53, 2) 0.176 (0.0372, 2) 96.2 (1.96, 2) ＞9950 (n=1/2) ND
381 0.0784 101 1.1 105 ＞9950 ND
382 0.0302 97.6 0.619 101 ＞9950 ND
383 0.0147 (0.00111, 2) 100 (1.51, 2) 0.306 (0.0408, 2) 105 (4.16, 2) ＞9950 (n=1/2) ND
384 0.0124 (0.000559, 2) 94.5 (3.49, 2) 0.308 (0.0612, 2) 98.2 (1.53, 2) ＞9950 (n=1/2) ND
385 0.0154 (0.00229, 2) 95.2 (1.73, 2) 0.189 (0.0226, 2) 100 (4.42, 2) ＞9950 (n=1/2) ND
386 0.0174 (0.00148, 2) 95.7 (4.77, 2) 0.194 (0.00360, 2) 98.9 (5.82, 2) ＞9950 (n=1/2) ND
387 0.0137 (0.0000708, 2) 102 (3.23, 2) 0.320 (0.125, 2) 101 (1.61, 2) ＞9950 (n=1/2) ND
388 0.0103 98.3 0.292 95.4 ＞9950 ND
389 0.0178 (0.000953, 2) 94.6 (0.800, 2) 0.190 (0.00883, 2) 92.4 (0.872, 2) ＞9950 (n=1/2) ND
390 0.0187 (0.00223, 3) 103 (1.73, 3) 0.209 (0.00349, 3) 97.7 (0.126, 3) ＞9950 (n=1/3) ND
391 0.0101 (0.000893, 4) 101 (2.26, 4) 0.167 (0.0161, 4) 109 (0.750, 4) ＞9950 (n=1/4) ND
392 0.0107 94.4 0.521 97.9 ＞9950 ND
393 0.0115 94.3 0.372 96.8 ＞9950 ND
394 0.0179 (0.00421, 2) 97.7 (4.16, 2) 0.223 (0.0106, 2) 101 (2.99, 2) ＞9950 (n=1/2) ND
395 0.0127 93.1 0.377 90.8 ＞9950 ND
396 0.0113 96.2 0.291 107 ＞9950 ND
397 0.0293 (0.0179, 2) 94.6 (2.83, 2) 0.166 (0.0101, 2) 95.8 (4.65, 2) ＞9950 (n=1/2) ND
398 0.0166 (0.000570, 2) 97.4 (0.108, 2) 0.215 (0.0107, 2) 101 (5.97, 2) ＞9950 (n=1/2) ND
399 0.0186 98.4 0.259 91.9 ＞9950 ND
400 0.0821 98.1 0.708 108 ＞9950 ND
401 0.0112 (0.00138, 3) 98.9 (1.97, 3) 0.235 (0.00554, 3) 104 (7.95, 3) ＞9950 (n=1/3) ND
402 0.0132 (0.00118, 3) 98.9 (2.45, 3) 0.221 (0.0238, 3) 107 (4.31, 3) ＞9950 (n=1/3) ND
403 0.00939 (0.000448, 3) 98.1 (1.21, 3) 0.175 (0.00248, 2) 108 (0.362, 2) ＞9950 (n=1/3) ND
404 0.014 101 0.632 94.3 ＞9950 ND
405 0.0209 100 1.26 93.3 ＞9950 ND
406 0.00896 (0.000684, 2) 101 (2.15, 2) 0.351 (0.0303, 2) 98.5 (5.32, 2) ＞9950 (n=1/2) ND
407 0.0114 (0.00120, 3) 99.2 (1.86, 3) 0.156 (0.00731, 3) 100 (2.08, 3) ＞9950 (n=1/3) ND
408 0.00888 (0.000279, 3) 99.7 (1.81, 3) 0.227 (0.0140, 3) 102 (2.46, 3) ＞9950 (n=1/3) ND
409 0.00928 (0.000716, 3) 99.2 (0.111, 3) 0.188 (0.0149, 3) 103 (0.304, 3) ＞9950 (n=1/3) ND
410 0.0118 (0.000492, 2) 99.1 (1.74, 2) 0.251 (0.147, 2) 94.0 (4.37, 2) ＞9950 (n=1/2) ND
411 0.0102 (0.00112, 3) 101 (0.677, 3) 0.167 (0.00866, 3) 110 (5.40, 3) ＞9950 (n=1/3) ND
412 0.0108 (0.00119, 3) 95.4 (0.413, 3) 0.160 (0.00954, 3) 108 (2.23, 3) ＞9950 (n=1/3) ND
413 0.0146 (0.00126, 3) 101 (1.34, 3) 0.234 (0.0297, 3) 96.9 (5.28, 3) ＞9950 (n=1/3) ND
414 0.00961 (0.000457, 4) 98.4 (1.10, 4) 0.119 (0.00178, 4) 103 (1.77, 4) ＞9950 (n=1/4) ND
415 0.00991 (0.000319, 4) 101 (0.864, 4) 0.122 (0.00605, 4) 109 (0.830, 4) ＞9950 (n=1/4) ND
416 0.0214 (0.000620, 3) 99.0 (2.74, 3) 0.332 (0.0140, 3) 104 (1.88, 3) ＞9950 (n=1/3) ND
417 0.00651 (0.000543, 4) 101 (3.45, 4) 0.0675 (0.00545, 4) 109 (2.32, 4) ＞9950 (n=1/4) ND
418 0.00599 (0.000221, 3) 91.0 (4.24, 3) 0.0603 (0.00801, 3) 93.7 (3.72, 3) ＞9950 (n=1/3) ND
419 0.00958 (0.00102, 3) 101 (2.60, 3) 0.132 (0.0105, 3) 113 (4.86, 3) ＞9950 (n=1/3) ND
420 0.00964 (0.000804, 2) 101 (0.422, 2) 0.123 (0.0177, 2) 99.7 (2.76, 2) ＞9950 (n=1/2) ND
421 0.00618 (0.000456, 5) 100 (4.89, 5) 0.0570 (0.00402, 5) 101 (4.19, 5) ＞9950 (n=1/5) ND
422 0.00655 (0.000179, 5) 104 (3.27, 5) 0.0729 (0.00508, 5) 106 (4.97, 5) ＞9950 (n=1/5) ND
423 0.00658 (0.000673, 5) 104 (2.28, 5) 0.0721 (0.00530, 5) 105 (3.34, 5) ＞9950 (n=1/5) ND
424 0.00502 (0.000436, 5) 101 (3.60, 5) 0.0427 (0.00649, 5) 102 (4.22, 5) ＞9950 (n=1/5) ND
425 0.00943 (0.000670, 2) 97.6 (2.09, 2) 0.0965 (0.000509, 2) 108 (1.41, 2) ＞9950 (n=1/2) ND
426 0.0191 93.3 0.206 97.2 ＞9950 (n=1/2) ND
427 0.0132 (0.000467, 2) 95.9 (0.131, 2) 0.206 (0.000352, 2) 109 (1.69, 2) ＞9950 (n=1/2) ND
428 0.00797 (0.000657, 2) 95.5 (1.18, 2) 0.102 (0.00942, 2) 106 (2.33, 2) ＞9950 (n=1/2) ND
429 0.00799 (0.000619, 2) 108 (1.47, 2) 0.116 (0.0211, 2) 116 (8.54, 2) ＞9950 (n=1/2) ND
430 0.0175 (0.00305, 2) 107 (3.65, 2) 0.342 (0.0582, 2) 93.1 (9.40, 2) ＞9950 (n=1/2) ND
431 0.00970 (0.000165, 2) 104 (2.51, 2) 0.134 (0.0264, 2) 99.2 (5.72, 2) ＞9950 (n=1/2) ND
432 0.00602 (0.000709, 5) 103 (4.98, 5) 0.0549 (0.00308, 5) 106 (5.75, 5) ＞9950 (n=1/5) ND
433 0.00972 (0.000248, 3) 94.0 (6.04, 3) 0.128 (0.00910, 3) 102 (3.73, 3) ＞9950 (n=1/3) ND
434 0.00704 (0.000555, 5) 98.3 (4.47, 5) 0.0837 (0.00431, 5) 104 (4.56, 5) ＞9950 (n=1/5) ND
435 0.00517 (0.000107, 5) 104 (5.02, 5) 0.0527 (0.00123, 5) 111 (2.21, 5) ＞9950 (n=1/5) ND
436 0.00714 (0.000579, 3) 102 (0.413, 3) 0.102 (0.00751, 3) 98.9 (3.69, 3) ＞9950 (n=1/3) ND
437 0.0146 (0.000707, 2) 94.8 (7.99, 2) 0.249 (0.0290, 2) 89.2 (2.76, 2) ＞9950 (n=1/2) ND
438 0.0157 (0.00257, 2) 98.9 (3.64, 2) 0.471 (0.0582, 2) 88.5 (0.533, 2) ＞9950 (n=1/2) ND
439 0.00799 (0.000558, 3) 96.0 (3.26, 3) 0.110 (0.0145, 3) 95.7 (2.01, 3) ＞9950 (n=1/3) ND
440 0.0104 (0.000447, 6) 102 (1.92, 6) 0.180 (0.0111, 6) 107 (2.68, 6) ＞10100 (n=1/6) ND
441 0.0174 (0.00153, 4) 97.2 (0.594, 4) 0.134 (0.0135, 4) 110 (4.43, 4) ＞9950 (n=1/4) ND
442 0.0129 (0.000387, 3) 101 (1.37, 3) 0.285 (0.0824, 3) 113 (7.08, 3) ＞9950 (n=1/3) ND
443 0.0178 (0.00241, 2) 102 (1.04, 2) 0.294 (0.00644, 2) 114 (3.48, 2) ＞9950 (n=1/2) ND
444 0.0157 (0.00115, 2) 93.6 (7.04, 2) 0.289 (0.00144, 2) 106 (8.34, 2) ＞9950 (n=1/2) ND
445 0.00728 (0.000110, 2) 102 (1.47, 2) 0.0781 (0.00635, 2) 103 (1.23, 2) ＞9950 (n=1/2) ND
446 0.0164 (0.000887, 3) 105 (4.26, 3) 0.162 (0.00890, 3) 103 (5.00, 3) ＞9950 (n=1/3) ND
447 0.0170 (0.00248, 3) 102 (7.41, 3) 0.219 (0.0213, 3) 105 (4.10, 3) ＞9950 (n=1/3) ND
448 0.0164 (0.00151, 3) 105 (3.52, 3) 0.157 (0.0114, 3) 104 (1.69, 3) ＞9950 (n=1/3) ND
449 0.0102 (0.000548, 5) 101 (1.21, 5) 0.160 (0.0159, 5) 112 (2.67, 5) ＞9950 (n=1/5) ND
450 0.0138 (0.000576, 5) 103 (1.18, 5) 0.201 (0.0102, 5) 120 (3.81, 5) ＞9950 (n=1/5) ND
451 0.0113 (0.000589, 5) 101 (2.33, 5) 0.172 (0.00777, 5) 118 (3.25, 5) ＞9950 (n=1/5) ND
452 0.0192 (0.00110, 3) 102 (1.68, 3) 0.259 (0.0104, 3) 117 (1.07, 3) ＞9950 (n=1/3) ND
453 0.0139 (0.00141, 5) 101 (1.94, 5) 0.200 (0.00941, 5) 116 (3.41, 5) ＞9950 (n=1/5) ND
454 0.0202 (0.00176, 4) 101 (1.53, 4) 0.266 (0.00975, 4) 114 (3.68, 4) ＞9950 (n=1/4) ND
455 0.0146 (0.00112, 5) 104 (1.34, 5) 0.219 (0.0123, 5) 117 (2.80, 5) ＞9950 (n=1/5) ND
456 0.0236 (0.00188, 3) 101 (2.59, 3) 0.341 (0.0277, 3) 116 (0.822, 3) ＞9950 (n=1/3) ND
457 0.0106 (0.00217, 4) 106 (3.22, 4) 0.185 (0.0580, 4) 119 (4.53, 4) ＞9950 (n=1/4) ND
458 0.0121 (0.000899, 4) 101 (3.63, 4) 0.179 (0.0147, 4) 111 (4.25, 4) ＞9950 (n=1/4) ND
459 0.0130 (0.00287, 4) 106 (3.71, 4) 0.180 (0.0192, 4) 120 (4.73, 4) ＞9950 (n=1/4) ND
460 0.0108 (0.00140, 4) 102 (2.05, 4) 0.187 (0.0213, 4) 111 (2.78, 4) ＞9950 (n=1/4) ND
461 0.0103 (0.000757, 4) 100 (3.07, 4) 0.173 (0.0146, 4) 108 (0.909, 4) ＞10100 (n=1/4) ND
462 0.0128 (0.00203, 3) 99.3 (3.59, 3) 0.189 (0.00876, 3) 113 (7.43, 3) ＞9950 (n=1/3) ND
463 0.0124 (0.00111, 3) 91.4 (3.32, 3) 0.267 (0.0917, 3) 111 (4.12, 3) ＞9950 (n=1/3) ND
464 0.00955 (0.000825, 4) 99.7 (1.97, 4) 0.161 (0.00664, 4) 114 (4.40, 4) ＞10100 (n=1/4) ND
465 0.0174 (0.00309, 3) 94.9 (2.15, 3) 0.413 (0.0329, 3) 98.6 (1.80, 3) ＞9950 (n=1/3) ND
466 0.00971 (0.000114, 2) 98.8 (0.994, 2) 0.156 (0.00268, 2) 105 (1.96, 2) ＞10100 (n=1/2) ND
467 0.0113 (0.00170, 2) 102 (4.24, 2) 0.131 (0.00641, 2) 110 (3.61, 2) ＞10100 (n=1/2) ND
468 0.00991 (0.000823, 2) 97.1 (2.96, 2) 0.168 (0.00905, 2) 109 (3.35, 2) ＞10100 (n=1/2) ND
469 0.0121 (0.00130, 2) 102 (1.70, 2) 0.161 (0.00141, 2) 111 (1.47, 2) ＞9950 (n=1/2) ND
470 0.0103 (0.00167, 2) 104 (7.15, 2) 0.127 (0.00754, 2) 112 (1.75, 2) ＞9950 (n=1/2) ND
471 0.0107 (0.000902, 2) 101 (5.62, 2) 0.143 (0.0220, 2) 112 (0.242, 2) ＞9950 (n=1/2) ND
472 0.0131 (0.00159, 2) 108 (3.90, 2) 0.154 (0.0130, 2) 118 (0.770, 2) ＞9950 (n=1/2) ND
473 0.0163 (0.00190, 2) 106 (3.37, 2) 0.192 (0.0132, 2) 118 (4.95, 2) ＞9950 (n=1/2) ND
474 0.0106 (0.00162, 2) 107 (1.06, 2) 0.123 (0.0104, 2) 113 (3.38, 2) ＞9950 (n=1/2) ND
475 0.0120 (0.000617, 2) 106 (2.22, 2) 0.143 (0.0302, 2) 116 (1.92, 2) ＞9950 (n=1/2) ND
476 0.00886 (0.00204, 2) 103 (0.456, 2) 0.117 (0.0135, 2) 114 (1.14, 2) ＞9950 (n=1/2) ND
477 0.00861 (0.00132, 2) 102 (1.19, 2) 0.143 (0.0278, 2) 110 (1.47, 2) ＞9950 (n=1/2) ND
478 0.0139 93.9 0.322 109 ＞9950 ND
479 0.00718 107 0.115 101 ＞9950 ND
480 0.00955 102 0.124 120 ＞9950 ND
481 0.0181 97.9 0.279 111 ＞9950 ND
482 0.0158 (0.00283, 2) 103 (2.04, 2) 0.169 (0.00139, 2) 118 (0.635, 2) ＞9950 (n=1/2) ND
483 0.0138 (0.0000352, 2) 97.4 (1.31, 2) 0.169 (0.0278, 2) 118 (4.57, 2) ＞9950 (n=1/2) ND
484 0.0136 (0.00267, 2) 102 (2.16, 2) 0.170 (0.00710, 2) 118 (0.624, 2) ＞9950 (n=1/2) ND
485 0.0113 (0.000946, 2) 106 (6.69, 2) 0.153 (0.00444, 2) 115 (0.806, 2) ＞10100 (n=1/2) ND
486 0.0143 (0.00116, 2) 94.1 (4.47, 2) 0.166 (0.00560, 2) 108 (0.513, 2) ＞9950 (n=1/2) ND
487 0.0161 (0.00374, 2) 103 (4.77, 2) 0.199 (0.0396, 2) 116 (5.51, 2) ＞9950 (n=1/2) ND
488 0.0115 (0.00121, 5) 104 (2.35, 5) 0.207 (0.0233, 5) 113 (2.17, 5) ＞10100 (n=1/5) ND
489 0.0131 (0.000283, 3) 103 (2.46, 3) 0.257 (0.0330, 3) 112 (5.59, 3) ＞10100 (n=1/3) ND
490 0.0122 (0.00221, 2) 110 (0.557, 2) 0.143 (0.0153, 2) 115 (3.29, 2) ＞9950 (n=1/2) ND
491 0.0148 (0.00265, 2) 100 (2.79, 2) 0.148 (0.00935, 2) 119 (2.42, 2) ＞9950 (n=1/2) ND
492 0.0125 (0.00109, 4) 101 (4.03, 4) 0.143 (0.0174, 4) 117 (2.36, 4) ＞9950 (n=1/4) ND
493 0.0155 (0.000342, 2) 105 (1.97, 2) 0.184 (0.0219, 2) 126 (3.27, 2) ＞9950 (n=1/2) ND
494 0.0123 (0.000792, 4) 101 (2.14, 4) 0.150 (0.00983, 4) 104 (3.60, 4) ＞9950 (n=1/4) ND
ND=未測定a 使用hGLP-1R處之[125 I]GLP-1(7-36)NH2 (112 fmol/mg蛋白質)、hGCGR處之[125 I]GCG(98 fmol/mg蛋白質)及hGIPR處之[125 I]GIP(1-42)(124 fmol/mg蛋白質)的同源競爭結合測定表現密度。b EC50 ，nM=幾何平均值，其後為括弧中之平均值標準誤差及觀測結果之數目。c Emax ，% =hGLP-1R處之GLP-1(7-36)NH2 、hGCGR處之GCG或hGIPR處之GIP(1-42)NH2 之最大反應百分比的算術平均值±平均值標準誤差。 所展示之所有值均為三(3)個有效數位。
表 3 ： 在 37 ℃ 下 ( 在 0.1% 牛酪蛋白及 1.0% 人類血清白蛋白存在下 ) 培育之肽之功能 cAMP 效能 (EC50 ) 及功效 (Emax ) 。
   hGIPRa hGLP-1Ra hGCGRa
實例 EC50 ，nM (SEM，n)b Emax，% ± SEMc EC50 ，nM (SEM，n)b Emax，% ± SEMc EC50 ，nM (SEM，n)b Emax，% ± SEMc
hGIP(1-42)NH2 0.597 (0.0522, 132) 98.0 ± 1.16            
hGLP-1(7-36)NH2       0.340 (0.0195, 133) 105 ± 1.39      
hGCG             2.37 (0.153, 135) 102 (se=1.49，n=135)
1 0.696 (0.0329, 3) 87.5 ± 3.24 30.7 (3.51, 3) 94.3 ± 4.39 ＞9950 (n=1/3) ND
6 0.0823 (0.00389, 3) 89.4 ± 1.74 4.19 (0.479, 3) 99.2 ± 5.54 ＞9950 (n=1/3) ND
2 0.659 (0.150, 2) 87.8 ± 5.11 32.1 (0.134, 2) 105 ± 3.87 ＞9950 (n=1/2) ND
3 0.0971 80 1.05 107 ＞9950 ND
4 0.0296 (0.00275, 4) 88.3 ± 2.17 0.584 (0.0543, 4) 98.2 ± 1.60 ＞9950 (n=1/4) ND
7 0.566 (0.0700, 5) 94.1 ± 2.10 2.74 (0.284, 5) 105 ± 2.62 ＞9950 (n=1/5) ND
8 0.635 (0.120, 3) 91.3 ± 3.11 8.00 (1.46, 3) 106 ± 3.25 ＞9950 (n=1/3) ND
5 0.372 (0.0352, 5) 91.2 ± 3.65 4.78 (0.559, 5) 103 ± 4.77 ＞9950 (n=1/5) ND
9 0.211 (0.0411, 3) 91.6 ± 4.63 8.82 (1.34, 3) 105 ± 3.71 ＞9950 (n=1/3) ND
10 0.121 (0.0130, 4) 84.9 ± 1.84 4.38 (0.399, 4) 99.8 ± 1.37 ＞9950 (n=1/4) ND
11 1.22 (0.0617, 4) 90.0 ± 2.71 34.5 (1.60, 4) 102 ± 0.940 ＞9950 (n=1/4) ND
12 0.745 (0.0971, 4) 93.0 ± 2.25 20.3 (2.83, 4) 103 ± 5.98 ＞9950 (n=1/4) ND
13 1.45 (0.180, 4) 95.1 ± 3.55 6.79 (0.450, 4) 95.9 ± 1.76 ＞9950 (n=1/4) ND
14 0.769 (0.0465, 4) 89.5 ± 1.02 9.19 (0.283, 4) 101 ± 2.00 ＞9950 (n=1/4) ND
15 0.573 (0.0563, 4) 94.4 ± 1.01 24.8 (0.964, 4) 93.2 ± 3.68 ＞9950 (n=1/4) ND
16 0.625 (0.0549, 4) 91.5 ± 1.01 9.06 (0.814, 4) 98.3 ± 0.735 ＞9950 (n=1/4) ND
17 0.605 (0.0691, 3) 88.9 ± 2.36 48.9 (6.33, 3) 99.3 ± 0.621 ＞9950 (n=1/3) ND
18 1.12 (0.150, 3) 86.9 ± 3.59 164 (42.5, 3) 103 ± 5.83 ＞9950 (n=1/3) ND
19 0.438 (0.0168, 3) 89.7 ± 2.13 24.4 (3.41, 3) 102 ± 2.33 ＞9950 (n=1/3) ND
20 1.66 (0.433, 2) 90.6 ± 0.878 62.4 (20.7, 2) 101 ± 4.72 ＞9950 (n=1/2) ND
21 0.302 (0.0443, 3) 94.2 ± 3.12 0.806 (0.119, 3) 107 ± 4.52 ＞9950 (n=1/3) ND
22 0.533 (0.0909, 3) 93.4 ± 0.775 1.50 (0.0680, 3) 101 ± 1.14 ＞9950 (n=1/3) ND
23 0.623 (0.0883, 3) 95.3 ± 0.863 1.98 (0.220, 3) 106 ± 1.77 ＞9950 (n=1/3) ND
24 0.444 (0.0309, 3) 92.4 ± 5.97 2.04 (0.143, 3) 103 ± 5.84 ＞9950 (n=1/3) ND
25 0.274 (0.0482, 3) 94.3 ± 1.73 1.11 (0.0768, 3) 103 ± 1.65 ＞9950 (n=1/3) ND
26 1.20 (0.0936, 3) 95.4 ± 2.54 3.93 (0.133, 3) 105 ± 3.59 ＞9950 (n=1/3) ND
27 6.78 (1.82, 2) 82.8 ± 1.14 70.2 (2.19, 2) 110 ± 3.03 ＞9950 (n=1/2) ND
28 2.08 (0.820, 2) 93.0 ± 7.02 60.4 (15.0, 2) 101 ± 2.12 ＞9950 (n=1/2) ND
29 0.472 (0.0549, 2) 96.9 ± 5.32 0.876 (0.104, 2) 107 ± 2.92 ＞9950 (n=1/2) ND
30 0.337 (0.252, 2) 91.8 ± 0.797 18.3 (3.71, 2) 96.5 ± 0.219 ＞9950 (n=1/2) ND
31 0.147 88.9 0.545 (0.128, 2) 109 ± 7.91 ＞9950 (n=1/2) ND
32 0.148 98.2 1.73 102 ＞9950 ND
33 0.0941 (0.0207, 2) 92.0 ± 1.02 4.35 (0.0139, 2) 109 ± 0.0920 ＞9950 (n=1/2) ND
34 0.213 (0.0165, 2) 89.1 ± 2.00 19.8 (3.06, 2) 107 ± 1.76 ＞9950 (n=1/2) ND
35 0.350 (0.00250, 2) 91.7 ± 1.28 16.4 (2.30, 2) 109 ± 0.873 ＞9950 (n=1/2) ND
36 0.408 (0.0282, 2) 91.4 ± 0.667 10.9 (1.38, 2) 101 ± 0.511 ＞9950 (n=1/2) ND
37 0.306 (0.0256, 2) 88.5 ± 0.188 17.0 (2.86, 2) 99.9 ± 4.41 ＞9950 (n=1/2) ND
38 0.539 (0.0934, 2) 88.8 ± 0.590 12.5 (1.43, 2) 115 ± 2.53 ＞9950 (n=1/2) ND
39 0.342 (0.00832, 2) 86.8 ± 3.27 7.98 (1.61, 2) 111 ± 1.02 ＞9950 (n=1/2) ND
40 0.301 (0.00465, 2) 92.2 ± 6.05 6.69 (2.15, 2) 103 ± 2.62 ＞9950 (n=1/2) ND
41 0.405 (0.0540, 2) 88.5 ± 0.638 27.2 (1.30, 2) 104 ± 3.41 ＞9950 (n=1/2) ND
42 1.000 (0.00288, 2) 91.1 ± 0.670 26.7 (4.92, 2) 105 ± 10.9 ＞9950 (n=1/2) ND
43 0.375 100 35.6 98.7 ＞9950 ND
44 1.68 87 125 94.5 ＞9950 ND
45 13.7 72.5 387 109 ＞9950 ND
46 12.8 73.3 261 117 ＞9950 ND
47 0.777 85.6 1670 134 ＞9950 ND
48 2.12 90.8 118 111 ＞9950 ND
49 1.51 (0.110, 3) 92.4 ± 4.07 20.1 (2.77, 3) 104 ± 0.273 ＞9950 (n=1/3) ND
50 1.81 (0.416, 3) 91.4 ± 4.20 27.8 (3.38, 3) 106 ± 0.713 ＞9950 (n=1/3) ND
51 15.8 90.7 100 92.9 ＞9950 ND
52 18.6 87.6 37.8 101 ＞9950 ND
53 3.53 (1.25, 3) 91.7 ± 1.16 13.2 (2.18, 3) 89.3 ± 6.12 ＞9950 (n=1/3) ND
54 0.865 85.6 20.3 103 ＞9950 ND
55 6.62 (0.645, 3) 85.7 ± 0.885 70.5 (4.49, 3) 112 ± 0.840 ＞9950 (n=1/3) ND
56 6.75 (0.962, 3) 91.4 ± 1.04 123 (8.75, 3) 123 ± 6.57 ＞9950 (n=1/3) ND
57 4.55 (0.383, 2) 92.1 ± 5.54 39.3 (0.445, 2) 114 ± 7.39 ＞9950 (n=1/2) ND
58 1.12 (0.134, 2) 92.2 ± 7.40 21.6 (2.74, 2) 106 ± 3.99 ＞9950 (n=1/2) ND
59 1.52 (0.323, 2) 90.3 ± 3.64 16.2 (2.88, 2) 108 ± 9.04 ＞9950 (n=1/2) ND
60 1.20 (0.0303, 2) 89.4 ± 4.57 28.5 (3.31, 2) 111 ± 3.97 ＞9950 (n=1/2) ND
61 0.744 92.8 36.9 89.7 ＞9950 ND
62 1.27 (0.343, 2) 94.3 ± 0.785 34.0 (10.3, 2) 85.8 ± 3.31 ＞9950 (n=1/2) ND
63 0.771 101 47.6 98 ＞9950 ND
64 0.986 (0.230, 2) 90.5 ± 3.44 27.0 (4.48, 2) 87.8 ± 0.301 ＞9950 (n=1/2) ND
65 1.05 (0.102, 2) 93.8 ± 6.73 25.5 (5.32, 2) 104 ± 2.15 ＞9950 (n=1/2) ND
66 0.787 (0.0298, 2) 90.6 ± 3.37 27.0 (8.48, 2) 93.0 ± 2.36 ＞9950 (n=1/2) ND
67 0.0417 91.9 12 104 ＞9950 ND
68 0.0831 92.4 5.79 102 ＞9950 ND
69 2.32 86.8 18.9 102 ＞9950 ND
70 1.73 (0.0380, 2) 89.9 ± 0.987 27.0 (3.69, 2) 106 ± 4.82 ＞9950 (n=1/2) ND
71 3.07 99.1 43.7 100 ＞9950 ND
72 3.55 95.9 40.1 98.8 ＞9950 ND
73 2.16 80.2 56.2 109 ＞9950 ND
74 2.19 86.7 59.5 110 ＞9950 ND
75 2.18 (0.153, 2) 87.8 ± 3.33 41.3 (8.02, 2) 97.0 ± 8.30 ＞9950 (n=1/2) ND
76 1.40 (0.683, 2) 89.9 ± 2.11 28.9 (1.46, 2) 100 ± 13.5 ＞9950 (n=1/2) ND
78 0.242 (0.0493, 2) 89.7 ± 2.65 4.29 (0.505, 2) 99.2 ± 0.361 ＞9950 (n=1/2) ND
79 2.31 95 15.1 109 ＞9950 ND
81 0.531 97.4 3.47 95 ＞9950 ND
87 4.84 89.2 80 101 ＞9950 ND
88 0.591 80.3 209 102 ＞9950 ND
89 1.49 94.2 27.7 108 ＞9950 ND
90 3.81 104 23.4 96.6 ＞9950 ND
91 7.05 91.9 20.4 89.8 ＞9950 ND
92 2.64 102 76.8 108 ＞9950 ND
93 5.58 92 66 90.2 ＞9950 ND
94 2.81 97.1 145 113 ＞9950 ND
95 4.68 86.9 8.84 84 ＞9950 ND
97 5.49 93.1 227 103 ＞9950 ND
98 4.97 95 58.1 97.5 ＞9950 ND
99 2.49 102 20 81.1 ＞9950 ND
100 2.61 98.3 402 123 ＞9950 ND
102 2.36 96.9 367 106 ＞9950 ND
103 0.515 94.2 35.5 96.9 ＞9950 ND
104 0.52 95.9 12.3 95.8 ＞9950 ND
131 0.0581 (0.00374, 2) 90.4 ± 1.62 1.04 (0.0207, 2) 112 ± 1.76 ＞9950 (n=1/2) ND
133 0.0695 (0.0139, 2) 89.1 ± 4.64 1.17 (0.0663, 2) 105 ± 5.52 ＞9950 (n=1/2) ND
135 0.0609 (0.0105, 2) 91.2 ± 4.78 0.936 (0.160, 2) 101 ± 1.98 ＞9950 (n=1/2) ND
137 0.728 (0.0218, 2) 90.3 ± 0.387 5.02 (0.348, 2) 103 ± 3.88 ＞9950 (n=1/2) ND
141 0.379 (0.0143, 2) 96.0 ± 7.42 5.78 (1.57, 2) 115 ± 2.04 ＞9950 (n=1/2) ND
150 0.350 (0.0449, 2) 81.3 ± 3.18 11.0 (2.84, 2) 100 ± 3.80 ＞9950 (n=1/2) ND
151 0.306 (0.0354, 2) 87.5 ± 3.78 17.3 (6.93, 2) 112 ± 8.42 ＞9950 (n=1/2) ND
153 1.15 (0.0744, 2) 94.1 ± 3.21 40.8 (6.36, 2) 98.2 ± 5.40 ＞9950 (n=1/2) ND
154 1.34 (0.0132, 2) 93.0 ± 4.96 70.5 (3.34, 2) 103 ± 3.93 ＞9950 (n=1/2) ND
155 1.25 (0.0855, 2) 96.5 ± 1.04 34.6 (4.78, 2) 102 ± 2.27 ＞9950 (n=1/2) ND
157 0.718 (0.0184, 2) 89.6 ± 3.39 36.0 (2.81, 2) 101 ± 4.27 ＞9950 (n=1/2) ND
164 3.62 93 26.6 95.4 ＞9950 ND
172 0.385 (0.0503, 2) 80.1 ± 2.06 7.70 (0.104, 2) 112 ± 10.3 ＞9950 (n=1/2) ND
173 1.24 (0.0219, 2) 92.9 ± 6.91 29.7 (4.49, 2) 99.5 ± 1.80 ＞9950 (n=1/2) ND
183 1.22 75.5 66.6 97.3 ＞9950 ND
184 2.46 81.2 119 87.8 ＞9950 ND
185 0.335 86.2 11.3 103 ＞9950 ND
186 2.19 85.6 24.3 107 ＞9950 ND
187 0.939 79.3 18 109 ＞9950 ND
188 1.37 89 19.1 106 ＞9950 ND
190 1.55 (0.169, 2) 82.8 ± 3.36 28.9 (0.482, 2) 112 ± 8.50 ＞9950 (n=1/2) ND
191 0.866 (0.0257, 2) 86.2 ± 5.50 13.1 (2.25, 2) 105 ± 7.98 ＞9950 (n=1/2) ND
192 0.832 (0.0527, 2) 93.6 ± 3.98 11.2 (3.64, 2) 121 ± 2.56 ＞9950 (n=1/2) ND
193 1.47 (0.124, 2) 92.2 ± 0.240 24.3 (4.18, 2) 104 ± 8.64 ＞9950 (n=1/2) ND
194 1.24 (0.0572, 2) 80.7 ± 7.81 21.2 (4.53, 2) 109 ± 10.5 ＞9950 (n=1/2) ND
195 0.771 (0.268, 2) 87.0 ± 12.2 14.0 (3.17, 2) 106 ± 2.61 ＞9950 (n=1/2) ND
196 0.712 (0.191, 2) 80.8 ± 0.269 21.4 (1.40, 2) 112 ± 4.62 ＞9950 (n=1/2) ND
197 2.06 (0.255, 2) 84.5 ± 4.08 26.2 (3.64, 2) 102 ± 2.64 ＞9950 (n=1/2) ND
198 1.06 (0.264, 2) 83.1 ± 3.45 14.5 (3.33, 2) 108 ± 0.518 ＞9950 (n=1/2) ND
199 2.45 77.1 70 100 ＞9950 ND
200 2.7 83.7 26.6 97.4 ＞9950 ND
201 13.2 80.5 25.1 104 ＞9950 ND
202 6.09 75.3 62.2 109 ＞9950 ND
203 0.682 87.2 3.38 105 ＞9950 ND
204 0.341 83.3 2.44 104 ＞9950 ND
205 0.261 (0.0684, 2) 72.1 (10.2, 2) 2.18 (0.439, 2) 106 (1.66, 2) ＞9950 (n=1/2) ND
206 0.242 (0.107, 2) 77.6 (6.91, 2) 3.03 (0.792, 2) 98.1 (0.421, 2) ＞9950 (n=1/2) ND
207 0.591 (0.0545, 2) 97.9 (9.30, 2) 2.98 (0.814, 2) 112 (10.5, 2) ＞9950 (n=1/2) ND
208 0.126 (0.0370, 2) 64.1 (0.979, 2) 1.58 (0.664, 2) 105 (8.90, 2) ＞9950 (n=1/2) ND
209 0.173 (0.0236, 2) 90.8 (2.77, 2) 1.16 (0.312, 2) 109 (4.47, 2) ＞9950 (n=1/2) ND
210 0.440 (0.0195, 2) 68.1 (7.17, 2) 8.86 (0.573, 2) 110 (7.68, 2) ＞9950 (n=1/2) ND
211 2.16 64.5 94.2 99 ＞9950 ND
212 16.6 81 33.7 91 ＞9950 ND
213 4.38 95.6 40.3 102 ＞9950 ND
214 2.03 80.4 17.9 108 ＞9950 ND
215 0.925 91.3 14.8 107 ＞9950 ND
216 5.31 63.4 32.3 117 ＞9950 ND
217 7.84 62.7 87.8 118 ＞9950 ND
218 3.27 95.9 36.6 121 ＞9950 ND
219 2.86 (1.19, 2) 82.9 (17.7, 2) 25.9 (3.30, 2) 101 (2.32, 2) ＞9950 (n=1/2) ND
220 11.6 83.5 150 110 ＞9950 ND
221 0.838 67.4 17.9 92.3 ＞9950 ND
222 2.1 77.9 13.8 117 ＞9950 ND
223 7.84 79.2 90.5 115 ＞9950 ND
224 2.92 90.6 71 102 ＞9950 ND
225 1.81 67.5 51.6 106 ＞9950 ND
226 4.86 92.1 11.3 118 ＞9950 ND
227 1.59 76.1 41.8 111 ＞9950 ND
228 3.37 83.3 42 119 ＞9950 ND
229 7.35 80.5 135 99 ＞9950 ND
230 2.57 (0.207, 3) 85.8 (2.02, 3) 49.7 (3.88, 3) 103 (3.29, 3) ＞9950 (n=1/3) ND
231 2.46 (0.528, 2) 85.4 (1.66, 2) 51.8 (5.87, 2) 109 (2.34, 2) ＞9950 (n=1/2) ND
232 1.86 91.5 33.6 95.4 ＞9950 ND
233 6.08 (0.278, 2) 91.4 (1.15, 2) 56.7 (19.2, 2) 116 (15.0, 2) ＞9950 (n=1/2) ND
234 7.58 84.4 156 102 ＞9950 ND
235 10.1 92.2 598 152 ＞9950 ND
236 0.641 (0.0940, 2) 80.5 (3.87, 2) 32.6 (4.16, 2) 125 (2.87, 2) ＞9950 (n=1/2) ND
237 0.889 (0.480, 2) 93.1 (3.84, 2) 38.1 (0.788, 2) 113 (2.42, 2) ＞9950 (n=1/2) ND
238 1.31 (0.644, 2) 90.5 (11.3, 2) 27.2 (1.11, 2) 103 (2.10, 2) ＞9950 (n=1/2) ND
239 5.46 (2.04, 2) 89.1 (0.575, 2) 25.2 (9.76, 2) 109 (1.64, 2) ＞9950 (n=1/2) ND
240 11.7 (0.555, 2) 87.2 (11.8, 2) 150 (5.84, 2) 107 (1.18, 2) ＞9950 (n=1/2) ND
241 8.02 (3.37, 2) 84.9 (9.74, 2) 103 (8.35, 2) 105 (4.79, 2) ＞9950 (n=1/2) ND
242 11.0 (5.42, 2) 83.9 (8.92, 2) 214 (35.7, 2) 102 (0.239, 2) ＞9950 (n=1/2) ND
243 0.728 (0.185, 3) 90.5 (0.658, 3) 34.7 (7.58, 3) 114 (12.1, 3) ＞9950 (n=1/3) ND
244 0.983 (0.411, 3) 89.5 (3.16, 3) 30.8 (6.22, 3) 96.3 (3.54, 3) ＞9950 (n=1/3) ND
245 0.552 (0.0557, 3) 81.9 (4.90, 3) 27.0 (1.02, 3) 93.8 (2.93, 3) ＞9950 (n=1/3) ND
246 1.63 (0.495, 3) 91.0 (3.43, 3) 22.9 (6.17, 3) 108 (9.08, 3) ＞9950 (n=1/3) ND
247 4.24 (0.948, 2) 90.2 (4.32, 2) 77.7 (0.558, 2) 109 (1.12, 2) ＞9950 (n=1/2) ND
248 4.10 (1.68, 2) 91.8 (0.258, 2) 56.7 (2.29, 2) 92.7 (4.61, 2) ＞9950 (n=1/2) ND
249 5.88 88.9 51.6 105 ＞9950 ND
250 38.8 101 63 105 ＞9950 ND
251 14.3 71.2 51 104 ＞9950 ND
252 29.9 87.2 131 115 ＞9950 ND
253 21.7 (1.79, 3) 78.9 (6.58, 3) 192 (28.9, 3) 114 (7.97, 3) ＞9950 (n=1/3) ND
254 16.8 (1.47, 3) 68.5 (4.32, 3) 211 (49.2, 3) 122 (16.8, 3) ＞9950 (n=1/3) ND
255 2.27 93.4 13.7 106 ＞9950 ND
256 1.5 75.3 12.6 95.5 ＞9950 ND
257 5.61 72.2 46.3 102 ＞9950 ND
258 5.28 84.3 41.5 103 ＞9950 ND
259 2.34 66.4 28.9 99.2 ＞9950 ND
260 3.27 83 32 107 ＞9950 ND
261 2.28 75.7 15.6 104 ＞9950 ND
262 8.15 79.7 69.8 115 ＞9950 ND
263 5.91 72.7 56.7 95.8 ＞9950 ND
264 7.12 84.4 75.2 105 ＞9950 ND
265 0.775 (0.0602, 2) 96.0 (0.960, 2) 5.14 (1.17, 2) 102 (2.46, 2) ＞9950 (n=1/2) ND
266 0.575 82.7 5.83 97.6 ＞9950 ND
267 0.808 88.1 8.46 104 ＞9950 ND
268 5.06 92.3 26.5 104 ＞9950 ND
269 2.65 (3.59, 3) 87.3 (0.702, 3) 46.5 (16.2, 3) 105 (4.56, 3) ＞9950 (n=1/3) ND
270 3.8 80.9 32.6 111 ＞9950 ND
271 0.767 97.3 10.2 122 ＞9950 ND
272 0.561 81.2 4.72 102 ＞9950 ND
273 0.318 88.4 40.9 90.5 ＞9950 ND
274 1.16 93.5 32.9 121 ＞9950 ND
275 0.926 101 33.5 103 ＞9950 ND
276 1.97 91.4 63.6 104 ＞9950 ND
277 0.962 99.3 12.2 93.1 ＞9950 ND
278 1.41 91.1 27 121 ＞9950 ND
279 3.21 88.6 36.6 114 ＞9950 ND
280 4.84 88.5 49.9 105 ＞9950 ND
281 1.87 97.9 22.4 91.7 ＞9950 ND
282 1.44 84.4 31.8 102 ＞9950 ND
283 4.88 114 49.5 96.6 ＞9950 ND
284 8.38 101 137 112 ＞9950 ND
285 1.28 84.7 136 105 ＞9950 ND
286 2.18 104 35 90.3 ＞9950 ND
287 3.76 98.9 83.8 106 ＞9950 ND
288 0.48 85.2 17.1 123 ＞9950 ND
289 3.11 94.9 627 170 ＞9950 ND
290 0.878 93.4 12.1 109 ＞9950 ND
291 0.833 92.9 7.43 100 ＞9950 ND
292 0.416 (0.0297, 5) 88.4 (4.96, 5) 4.35 (0.151, 5) 101 (2.62, 5) ＞9950 (n=1/5) ND
293 0.987 (0.168, 3) 96.6 (2.52, 3) 10.7 (0.553, 3) 99.4 (3.13, 3) ＞9950 (n=1/3) ND
294 0.833 107 6.26 104 ＞9950 ND
295 1.09 99.6 10.4 101 ＞9950 ND
296 0.823 91.9 13 109 ＞9950 ND
297 1.54 93.7 19.1 108 ＞9950 ND
298 0.237 (0.0133, 3) 95.0 (3.55, 3) 3.64 (1.18, 3) 107 (10.3, 3) ＞9950 (n=1/3) ND
299 0.204 (0.0143, 3) 99.8 (4.40, 3) 2.58 (0.211, 3) 102 (1.94, 3) ＞9950 (n=1/3) ND
300 1.25 (0.0915, 3) 91.5 (6.45, 3) 19.6 (2.89, 3) 109 (2.14, 3) ＞9950 (n=1/3) ND
301 0.919 (0.0935, 2) 85.5 (3.43, 2) 12.9 (0.666, 2) 106 (7.59, 2) ＞9950 (n=1/2) ND
302 0.453 (0.00185, 2) 86.3 (0.816, 2) 6.55 (0.397, 2) 99.4 (1.04, 2) ＞9950 (n=1/2) ND
303 2 89.8 50.4 111 ＞9950 ND
304 4.83 99.3 64.2 98.3 ＞9950 ND
305 4.34 95.4 80.3 125 ＞9950 ND
306 1.12 102 18.2 102 ＞9950 ND
307 1.66 81.8 33 109 ＞9950 ND
308 10.5 98.4 67.3 92.2 ＞9950 ND
309 6.08 95.3 64.6 106 ＞9950 ND
310 2.4 83.9 22 106 ＞9950 ND
311 2.16 98.3 33.8 104 ＞9950 ND
312 4.48 89.5 50.8 112 ＞9950 ND
313 21.9 101 98.8 95 ＞9950 ND
314 3.51 101 38.6 102 ＞9950 ND
315 0.393 89.2 5.38 93.5 ＞9950 ND
316 1.11 102 19.2 113 ＞9950 ND
317 2.03 (0.0584, 2) 84.4 (8.11, 2) 29.5 (4.64, 2) 98.1 (5.04, 2) ＞9950 (n=1/2) ND
318 5.42 (0.737, 2) 91.4 (2.19, 2) 28.7 (1.02, 2) 101 (1.14, 2) ＞9950 (n=1/2) ND
319 3.35 (1.04, 2) 92.5 (5.28, 2) 28.1 (3.97, 2) 114 (17.1, 2) ＞9950 (n=1/2) ND
320 0.338 84.1 6.22 99.2 ＞9950 ND
321 0.631 94.5 13.9 96.6 ＞9950 ND
322 0.617 (0.107, 5) 89.7 (3.98, 5) 8.09 (0.489, 5) 94.5 (2.57, 5) ＞9950 (n=1/5) ND
323 0.694 92.9 9.52 104 ＞9950 ND
324 0.321 (0.0210, 5) 85.4 (4.62, 5) 4.38 (0.281, 5) 99.4 (4.29, 5) ＞9950 (n=1/5) ND
325 3.96 (0.456, 2) 94.7 (5.70, 2) 23.5 (6.01, 2) 98.4 (2.48, 2) ＞9950 (n=1/2) ND
326 4.62 (0.384, 2) 88.7 (7.81, 2) 26.1 (0.140, 2) 96.1 (2.59, 2) ＞9950 (n=1/2) ND
327 0.751 90.2 13.6 97.6 ＞9950 ND
328 0.75 85.5 23.3 102 ＞9950 ND
329 5.44 100 74.7 88.3 ＞9950 ND
330 6.26 103 85.2 85 ＞9950 ND
331 8.31 108 223 114 ＞9950 ND
332 4.59 96.5 33.3 116 ＞9950 ND
333 6.74 100 70.4 93.3 ＞9950 ND
334 0.618 (0.0980, 5) 89.0 (3.96, 5) 8.67 (0.430, 5) 105 (3.28, 5) ＞9950 (n=1/5) ND
335 1.04 85.2 12.3 101 ＞9950 ND
336 2.92 (0.0217, 2) 94.6 (4.74, 2) 47.0 (6.26, 2) 103 (8.40, 2) ＞10100 (n=1/2) ND
337 2.65 (0.235, 2) 86.8 (4.14, 2) 53.6 (8.71, 2) 100 (1.63, 2) ＞10100 (n=1/2) ND
338 1.24 (0.0430, 2) 83.9 (2.56, 2) 36.6 (6.57, 2) 103 (1.43, 2) ＞10100 (n=1/2) ND
339 4.35 (0.915, 2) 87.3 (9.37, 2) 68.2 (10.6, 2) 115 (6.65, 2) ＞10100 (n=1/2) ND
340 9.91 87.9 122 112 ＞9950 ND
341 5.74 (0.563, 2) 83.6 (3.95, 2) 95.8 (1.69, 2) 113 (8.64, 2) ＞9950 (n=1/2) ND
342 1.04 (0.0681, 2) 89.3 (1.18, 2) 13.6 (0.635, 2) 101 (2.94, 2) ＞9950 (n=1/2) ND
343 2.38 90.2 20.2 98.2 ＞9950 ND
344 6.78 87.3 48.3 96.5 ＞9950 ND
345 0.731 (0.0103, 2) 86.8 (8.74, 2) 11.8 (1.13, 2) 110 (2.77, 2) ＞9950 (n=1/2) ND
346 1.83 83.9 19 97.7 ＞9950 ND
347 7.27 84.6 51.7 99.5 ＞9950 ND
348 1.79 79.3 8.95 98 ＞9950 ND
349 0.606 79.3 5.15 94.3 ＞9950 ND
350 5.82 73.5 6.4 91.4 ＞9950 ND
351 0.722 67.9 5.8 91 ＞9950 ND
352 0.277 71.3 5.46 93.5 ＞9950 ND
353 5.35 84.8 7.12 92.5 ＞9950 ND
354 0.857 67.5 7.25 95.9 ＞9950 ND
355 1.81 86 11.3 109 ＞9950 ND
356 2.47 82.7 23.4 93 ＞9950 ND
357 1.19 (0.250, 2) 78.2 (14.7, 2) 36.2 (2.98, 2) 92.8 (1.82, 2) ＞9950 (n=1/2) ND
358 2.06 (0.735, 2) 86.2 (0.397, 2) 65.3 (2.90, 2) 102 (4.28, 2) ＞9950 (n=1/2) ND
359 1.58 (0.643, 2) 81.0 (10.1, 2) 40.5 (4.21, 2) 95.1 (1.93, 2) ＞9950 (n=1/2) ND
360 1.91 (0.0821, 2) 84.3 (10.5, 2) 28.2 (0.0380, 2) 97.1 (5.05, 2) ＞9950 (n=1/2) ND
361 1.44 (0.180, 2) 88.8 (5.34, 2) 43.0 (0.650, 2) 98.8 (3.89, 2) ＞9950 (n=1/2) ND
362 0.936 (0.0457, 2) 86.7 (0.254, 2) 29.9 (0.294, 2) 107 (6.56, 2) ＞9950 (n=1/2) ND
363 0.976 91.1 14.3 111 ＞9950 ND
364 0.895 89.1 13 102 ＞9950 ND
365 1.93 93.5 22.3 91 ＞9950 ND
366 3.14 95.9 96.2 98.3 ＞9950 ND
372 3.75 90.6 38 101 ＞9950 ND
373 2.84 82.4 37.4 112 ＞9950 ND
374 1.96 88.8 39.7 108 ＞9950 ND
375 4.68 85.4 56.1 113 ＞9950 ND
376 39.6 88.3 419 121 ＞9950 ND
377 17.5 79.4 178 110 ＞9950 ND
378 7.46 (0.401, 2) 81.2 (0.297, 2) 47.7 (5.86, 2) 104 (2.97, 2) ＞9950 (n=1/2) ND
379 11.6 (3.09, 2) 90.0 (2.40, 2) 48.5 (1.05, 2) 101 (1.65, 2) ＞9950 (n=1/2) ND
380 9.23 (1.41, 2) 93.5 (4.71, 2) 28.0 (2.79, 2) 94.5 (0.549, 2) ＞9950 (n=1/2) ND
381 28 90.3 153 106 ＞9950 ND
382 18.7 87.2 204 118 ＞9950 ND
383 10.7 (0.361, 2) 82.8 (0.0145, 2) 92.2 (7.22, 2) 102 (1.72, 2) ＞9950 (n=1/2) ND
384 0.457 (0.0717, 2) 83.5 (7.50, 2) 5.32 (0.0375, 2) 99.5 (3.98, 2) ＞9950 (n=1/2) ND
385 0.558 (0.0738, 2) 83.5 (1.48, 2) 10.6 (0.719, 2) 112 (4.74, 2) ＞9950 (n=1/2) ND
386 2.08 (0.338, 2) 81.3 (1.47, 2) 17.7 (0.911, 2) 96.8 (3.81, 2) ＞9950 (n=1/2) ND
387 0.278 (0.00115, 2) 93.0 (6.92, 2) 4.40 (1.07, 2) 103 (1.08, 2) ＞9950 (n=1/2) ND
388 0.463 82.1 6.31 104 ＞9950 ND
389 1.50 (0.343, 2) 82.0 (2.14, 2) 9.58 (1.62, 2) 106 (0.535, 2) ＞9950 (n=1/2) ND
390 3.85 (0.361, 3) 89.3 (3.58, 3) 24.3 (1.05, 3) 94.6 (2.35, 3) ＞9950 (n=1/3) ND
391 0.266 (0.0311, 4) 88.3 (1.76, 4) 2.62 (0.437, 4) 105 (2.45, 4) ＞9950 (n=1/4) ND
392 0.797 85.7 3.14 93.7 ＞9950 ND
393 0.547 66.7 9.18 103 ＞9950 ND
394 1.38 (0.437, 2) 84.6 (11.0, 2) 5.83 (1.31, 2) 96.8 (7.02, 2) ＞9950 (n=1/2) ND
395 0.327 57.8 6.26 96.1 ＞9950 ND
396 0.595 67.1 6.49 94.4 ＞9950 ND
397 1.92 (0.780, 2) 84.5 (11.6, 2) 7.17 (0.884, 2) 103 (8.65, 2) ＞9950 (n=1/2) ND
398 5.40 (1.52, 2) 91.9 (0.357, 2) 41.3 (4.18, 2) 106 (4.28, 2) ＞9950 (n=1/2) ND
399 16.2 86.8 43.6 89.7 ＞9950 ND
400 16.7 83.2 107 109 ＞9950 ND
401 0.434 (0.0341, 3) 83.0 (7.25, 3) 5.39 (0.0937, 3) 107 (3.32, 3) ＞9950 (n=1/3) ND
402 1.11 (0.0989, 3) 84.5 (0.945, 3) 13.5 (2.55, 3) 110 (5.84, 3) ＞9950 (n=1/3) ND
403 0.711 (0.103, 3) 91.7 (6.87, 3) 7.31 (0.446, 3) 107 (2.08, 3) ＞9950 (n=1/3) ND
404 1.74 77.3 49.1 99.3 ＞9950 ND
405 1.23 74.3 37.5 78.1 ＞9950 ND
406 0.527 (0.130, 2) 87.3 (2.48, 2) 9.21 (0.435, 2) 96.0 (2.59, 2) ＞9950 (n=1/2) ND
407 1.87 (0.139, 3) 95.4 (4.35, 3) 12.4 (1.15, 3) 97.2 (2.74, 3) ＞9950 (n=1/3) ND
408 0.299 (0.0439, 3) 84.4 (2.26, 3) 5.92 (0.553, 3) 99.5 (3.91, 3) ＞9950 (n=1/3) ND
409 0.537 (0.0122, 3) 84.0 (0.901, 3) 8.05 (0.761, 3) 97.7 (3.00, 3) ＞9950 (n=1/3) ND
410 1.28 (0.255, 2) 86.4 (5.77, 2) 11.0 (0.428, 2) 93.1 (0.997, 2) ＞9950 (n=1/2) ND
411 1.09 (0.153, 3) 84.6 (2.63, 3) 11.4 (1.88, 3) 101 (2.54, 3) ＞9950 (n=1/3) ND
412 1.57 (0.136, 3) 87.5 (2.85, 3) 18.3 (1.35, 3) 106 (3.38, 3) ＞9950 (n=1/3) ND
413 0.422 (0.0398, 3) 91.8 (3.88, 3) 5.47 (0.460, 3) 107 (4.11, 3) ＞9950 (n=1/3) ND
414 0.274 (0.0130, 5) 92.2 (1.90, 5) 3.24 (0.450, 5) 103 (3.30, 5) ＞9950 (n=1/5) ND
415 0.492 (0.0557, 4) 93.9 (2.34, 4) 5.72 (0.324, 4) 104 (3.90, 4) ＞9950 (n=1/4) ND
416 0.723 (0.0458, 3) 83.0 (5.25, 3) 10.1 (0.689, 3) 109 (2.55, 3) ＞9950 (n=1/3) ND
417 0.201 (0.0212, 4) 96.4 (1.41, 4) 2.66 (0.254, 4) 104 (2.88, 4) ＞9950 (n=1/4) ND
418 0.126 (0.0101, 3) 87.2 (4.56, 3) 1.72 (0.202, 3) 98.8 (3.48, 3) ＞9950 (n=1/3) ND
419 0.440 (0.0108, 3) 88.2 (0.828, 3) 7.19 (1.28, 3) 97.3 (3.90, 3) ＞9950 (n=1/3) ND
420 0.351 (0.0281, 2) 89.7 (1.93, 2) 10.0 (1.52, 2) 109 (14.4, 2) ＞9950 (n=1/2) ND
421 0.164 (0.0176, 5) 98.0 (2.76, 5) 2.01 (0.326, 5) 105 (3.71, 5) ＞9950 (n=1/5) ND
422 0.199 (0.0226, 5) 97.5 (1.55, 5) 3.84 (0.645, 4) 102 (6.38, 4) ＞9950 (n=1/5) ND
423 0.294 (0.0208, 5) 89.7 (3.15, 5) 4.74 (0.644, 5) 99.5 (3.90, 5) ＞9950 (n=1/5) ND
424 0.159 (0.0110, 5) 89.5 (1.11, 5) 3.07 (0.179, 5) 98.1 (3.03, 5) ＞9950 (n=1/5) ND
425 0.875 (0.138, 2) 89.9 (1.77, 2) 10.3 (0.951, 2) 103 (0.221, 2) ＞9950 (n=1/2) ND
426 3.88 (0.200, 2) 91.2 (3.07, 2) 29.7 (2.34, 2) 106 (11.5, 2) ＞9950 (n=1/2) ND
427 2.04 (0.124, 2) 92.4 (2.27, 2) 25.1 (5.36, 2) 109 (1.53, 2) ＞9950 (n=1/2) ND
428 0.748 (0.0265, 2) 93.6 (1.01, 2) 10.2 (0.217, 2) 105 (7.48, 2) ＞9950 (n=1/2) ND
429 1.03 (0.0757, 2) 93.3 (2.97, 2) 17.3 (0.623, 2) 101 (1.10, 2) ＞9950 (n=1/2) ND
430 1.09 (0.108, 2) 91.5 (4.62, 2) 26.8 (3.10, 2) 88.5 (3.34, 2) ＞9950 (n=1/2) ND
431 0.645 (0.0819, 2) 98.0 (6.44, 2) 17.5 (0.336, 2) 91.6 (8.16, 2) ＞9950 (n=1/2) ND
432 0.0875 (0.00975, 5) 96.7 (2.20, 5) 1.28 (0.177, 5) 103 (1.27, 5) ＞9950 (n=1/5) ND
433 0.136 (0.0247, 3) 100.0 (3.94, 3) 2.63 (0.319, 2) 101 (5.22, 2) ＞9950 (n=1/3) ND
434 0.0994 (0.0113, 5) 97.5 (2.66, 5) 1.73 (0.292, 5) 101 (2.09, 5) ＞9950 (n=1/5) ND
435 0.0873 (0.00638, 5) 98.7 (2.49, 5) 1.63 (0.153, 5) 97.8 (2.96, 5) ＞9950 (n=1/5) ND
436 0.241 (0.0446, 3) 96.0 (0.351, 3) 4.98 (0.430, 3) 100 (3.07, 3) ＞9950 (n=1/3) ND
437 0.461 (0.0212, 2) 96.5 (2.42, 2) 9.65 (2.23, 2) 91.2 (10.9, 2) ＞9950 (n=1/2) ND
438 0.592 (0.100, 2) 90.8 (1.84, 2) 28.0 (1.64, 2) 88.7 (20.6, 2) ＞9950 (n=1/2) ND
439 0.396 (0.0386, 3) 91.7 (2.17, 3) 9.25 (2.51, 3) 97.0 (5.24, 3) ＞9950 (n=1/3) ND
440 0.209 (0.0138, 6) 90.3 (1.85, 6) 2.74 (0.115, 6) 106 (1.98, 6) ＞10100 (n=1/6) ND
441 1.38 (0.172, 4) 83.8 (2.04, 4) 5.75 (0.561, 4) 111 (3.26, 4) ＞9950 (n=1/4) ND
442 0.687 (0.179, 3) 92.1 (4.96, 3) 7.63 (2.89, 3) 106 (1.76, 3) ＞9950 (n=1/3) ND
443 12.2 (1.51, 2) 91.1 (1.74, 2) 133 (5.04, 2) 99.3 (0.923, 2) ＞9950 (n=1/2) ND
444 0.570 (0.0249, 2) 83.6 (0.143, 2) 7.51 (1.10, 2) 98.8 (2.42, 2) ＞9950 (n=1/2) ND
445 1.17 (0.102, 2) 91.4 (0.322, 2) 13.1 (0.359, 2) 100 (0.430, 2) ＞9950 (n=1/2) ND
446 5.14 (1.45, 3) 97.0 (4.46, 3) 33.5 (2.16, 3) 105 (1.85, 3) ＞9950 (n=1/3) ND
447 1.46 (0.413, 3) 101 (2.70, 3) 7.85 (0.457, 3) 98.4 (2.10, 3) ＞9950 (n=1/3) ND
448 1.41 (0.531, 3) 99.2 (0.884, 3) 7.91 (0.258, 3) 99.5 (1.45, 3) ＞9950 (n=1/3) ND
449 0.595 (0.0397, 5) 92.1 (4.58, 5) 7.27 (0.337, 5) 103 (5.19, 5) ＞9950 (n=1/5) ND
450 2.44 (0.532, 5) 91.4 (4.33, 5) 32.3 (4.94, 5) 102 (6.79, 5) ＞9950 (n=1/5) ND
451 0.518 (0.103, 5) 89.5 (2.84, 5) 7.23 (0.798, 5) 108 (5.40, 5) ＞9950 (n=1/5) ND
452 1.21 (0.251, 3) 100 (1.68, 3) 16.8 (2.48, 3) 108 (2.85, 3) ＞9950 (n=1/3) ND
453 0.451 (0.0791, 5) 92.0 (0.901, 5) 5.47 (0.327, 5) 108 (3.80, 5) ＞9950 (n=1/5) ND
454 1.30 (0.201, 4) 91.5 (0.474, 4) 18.6 (1.80, 4) 103 (1.41, 4) ＞9950 (n=1/4) ND
455 0.362 (0.0529, 5) 91.8 (1.84, 5) 5.24 (0.295, 5) 108 (2.00, 5) ＞9950 (n=1/5) ND
456 0.878 (0.170, 3) 94.7 (3.21, 3) 14.7 (1.55, 3) 112 (5.14, 3) ＞9950 (n=1/3) ND
457 0.334 (0.0519, 4) 92.7 (3.24, 4) 4.69 (1.37, 4) 103 (3.76, 4) ＞9950 (n=1/4) ND
458 0.726 (0.0737, 4) 93.1 (2.31, 4) 7.61 (0.921, 4) 106 (2.53, 4) ＞9950 (n=1/4) ND
459 0.323 (0.0736, 4) 89.3 (1.16, 4) 4.87 (0.929, 4) 104 (2.02, 4) ＞9950 (n=1/4) ND
460 0.506 (0.0729, 4) 89.5 (3.45, 4) 6.31 (0.982, 4) 99.5 (3.37, 4) ＞9950 (n=1/4) ND
461 0.247 (0.0520, 4) 98.5 (0.822, 4) 2.76 (0.361, 4) 105 (2.29, 4) ＞10100 (n=1/4) ND
462 0.317 (0.0572, 3) 98.4 (2.45, 3) 3.34 (0.719, 3) 104 (2.72, 3) ＞9950 (n=1/3) ND
463 0.350 (0.0916, 3) 93.7 (3.44, 3) 4.09 (0.287, 2) 103 (7.01, 2) ＞9950 (n=1/3) ND
464 0.316 (0.0436, 4) 95.5 (4.97, 4) 4.48 (0.715, 4) 104 (5.47, 4) ＞10100 (n=1/4) ND
465 3.63 (0.920, 3) 94.4 (1.30, 3) 73.2 (8.31, 3) 93.3 (9.91, 3) ＞9950 (n=1/3) ND
466 0.314 (0.0445, 2) 93.4 (2.04, 2) 3.32 (0.194, 2) 99.8 (9.14, 2) ＞10100 (n=1/2) ND
467 0.35 88.4 2.87 97.9 ＞10100 (n=1/2) ND
468 0.222 85.9 1.84 102 ＞10100 (n=1/2) ND
469 0.203 82.1 2.33 93.8 ＞9950 (n=1/2) ND
470 0.719 93.9 4.54 113 ＞9950 (n=1/2) ND
471 0.568 90.1 4.36 110 ＞9950 (n=1/2) ND
472 0.663 76.3 7.41 103 ＞9950 (n=1/2) ND
473 0.979 92.8 7.07 114 ＞9950 (n=1/2) ND
474 0.156 85.6 1.1 104 ＞9950 (n=1/2) ND
475 0.211 84.6 1.44 102 ＞9950 (n=1/2) ND
476 0.154 81.8 1.5 107 ＞9950 (n=1/2) ND
477 0.163 88.1 1.56 110 ＞9950 (n=1/2) ND
478 0.517 84 6.16 108 ＞9950 ND
479 0.196 89.5 2.55 95.3 ＞9950 ND
480 0.29 99.7 2.65 104 ＞9950 ND
481 0.467 82.7 6.16 112 ＞9950 ND
482 0.89 104 4.85 110 ＞9950 (n=1/2) ND
483 0.297 92.6 3.33 113 ＞9950 (n=1/2) ND
484 0.453 91.3 3.66 103 ＞9950 (n=1/2) ND
485 0.536 93.8 3.9 104 ＞9950 ND
486 0.239 88.2 2 102 ＞9950 (n=1/2) ND
487 0.429 89.1 3.16 104 ＞9950 (n=1/2) ND
488 0.718 (0.161, 2) 85.5 (1.49, 2) 13.0 (0.709, 2) 106 (4.29, 2) ＞9950 (n=1/3) ND
489 0.578 79.4 13.5 98.7 ＞9950 ND
490 0.976 97.1 7.68 101 ＞9950 ND
491 1.08 87.5 5.51 105 ＞9950 ND
492 0.371 88.7 4.31 104 ＞9950 (n=1/2) ND
493 0.591 94.6 7.24 102 ＞9950 ND
494 0.699 (0.0883, 4) 92.6 (3.07, 4) 9.17 (1.83, 4) 106 (3.43, 4) ＞9950 (n=1/4) ND
ND=未測定a 使用hGLP-1R處之[125 I]GLP-1(7-36)NH2 (112 fmol/mg蛋白質)、hGCGR處之[125 I]GCG(98 fmol/mg蛋白質)及hGIPR處之[125 I]GIP(1-42)(124 fmol/mg蛋白質)的同源競爭結合測定表現密度。b EC50 ，nM=幾何平均值，其後為括弧中之平均值標準誤差及觀測結果之數目。c Emax ，% =hGLP-1R處之GLP-1(7-36)NH2 、hGCGR處之GCG或hGIPR處之GIP(1-42)NH2 之最大反應百分比的算術平均值±平均值標準誤差。 所展示之所有值均為三(3)個有效數位。
活體內研究
雄性 CD-1 小鼠中之藥物動力學 在單次皮下投與200 nMol/kg至雄性CD-1小鼠之後，評估測試肽之藥物動力學。經168小時收集血液樣品且使用所得個別血漿濃度計算藥物動力學參數。使用量測測試肽之完整質量的合格LC/MS方法測定血漿(K3 EDTA)濃度。利用基於免疫親和力之沈澱法，使用抗GIP/GLP1抗體，自100%小鼠血漿提取各測試肽及類似物作為內標。組合儀器以進行LC/MS偵測。平均藥物動力學參數判定該測試肽是否與延長之藥物動力學概況一致。
雄性 威斯達 大鼠 (Wistar Rat) 中之胰島素分泌 將具有股動脈及股靜脈管之雄性威斯達大鼠(Envigo, Indianapolis, IN) (280至320公克)單隻圈養於具有過濾頂的聚碳酸酯籠中。大鼠在21℃下以12:12小時晝夜循環(上午6:00開燈)維持且任意接受食物及去離子水。大鼠根據體重隨機分組且以0.04、0.1、0.3、1、3及10 nmol/kg之測試肽劑量皮下給藥1.5 ml/kg，16小時後投與葡萄糖，接著禁食。將動物稱重且經由腹膜內給予戊巴比妥鈉(65 mg/kg，30 mg/ml)進行麻醉。將0時血液樣品收集於EDTA管中，隨後靜脈內投與葡萄糖(0.5 mg/kg，5 ml/kg)。靜脈內投與葡萄糖之後的第2、4、6、10、20及30分鐘時收集血液樣品以獲得葡萄糖及胰島素含量。使用臨床化學分析儀測定血漿葡萄糖含量。使用電化學發光分析(Meso Scale, Gaithersburg, MD)測定血漿胰島素。相較於媒劑對照組，檢查葡萄糖及胰島素AUC，其中n=5隻動物/組。呈現結果(SEM)(N)。結果展示測試肽在靜脈內葡萄糖耐受性測試期間對胰島素分泌之作用。結果展示測試肽對胰島素分泌之劑量依賴性作用。
飲食誘發之肥胖 C57/B16 小鼠 使用飲食誘發肥胖(DIO)之C57/Bl6雄性小鼠(Taconic, Germantown, NY)，其體重為41-50 g。將動物單獨地圈養於12小時晝夜光週期(上午10:00關燈且晚上10:00開燈)的溫度可控(24℃)設施內，自由取食及取水。適應設施2週之後，小鼠根據體重隨機分配至處理組(n=6隻/組)，因此各組具有類似的起始平均體重。
小鼠用媒劑(40 mM Tris-HCl，pH 8.0)或約0.03 nmol/kg至約10 nmol/kg劑量範圍之間的測試肽處理。每天暗循環開始之前的30至90分鐘，向任意餵食的DIO小鼠皮下投與治療(QD)，歷時14天。每日監測體重及食物攝入。
資料表示為每組5至6隻大鼠之平均值±SEM。藉由單向ANOVA，隨後藉由鄧尼特氏多重比較檢驗(Dunnett's multiple comparison test)來評估統計分析，以將處理組與媒劑組比較或彼此比較。p＜0.05鑑別為顯著差異。
Figure 02_image021
「0」劑量組表示各研究期間的經媒劑處理之小鼠。所有資料表示為每組5至6隻小鼠之平均值±SEM。「相對於媒劑的Δ」係指測試組與媒劑組第15天之體重之間的差異。「變化%」係指測試組體重在第1天與第15天之間的降低百分比。記錄接受媒劑之動物之體重降低百分比。分析中測試呈陽性之肽的相對於媒劑之Δ及變化%資料在統計學上顯著不同於(p＜0.05)對照。
胺基酸序列 SEQ ID NO:1 GIP (人類)
Figure 02_image023
SEQ ID NO:2 升糖素(人類)
Figure 02_image025
SEQ ID NO:3 GLP-1 (7-36) (人類)
Figure 02_image027
SEQ ID NO:4
Figure 02_image029
SEQ ID NO:5
Figure 02_image031
SEQ ID NO:6
Figure 02_image033
SEQ ID NO:7
Figure 02_image035
SEQ ID NO:8
Figure 02_image037
SEQ ID NO:9
Figure 02_image039
SEQ ID NO:10
Figure 02_image041
SEQ ID NO:11 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 SEQ ID NO:12 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))SSGAPPPS-NH2 SEQ ID NO:13 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(4-(4-碘苯基)丁醯基))AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(4-(4-碘苯基)丁醯基))SSGAPPPS-NH2 SEQ ID NO:14 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(4-(4-三級-丁基苯基)丁醯基))AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(4-(4-三級-丁基苯基)丁醯基))SSGAPPPS-NH2 SEQ ID NO:15 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )SSGAPPPS-NH2
Figure 12_A0101_SEQ_0001
Figure 12_A0101_SEQ_0002
Figure 12_A0101_SEQ_0003
Figure 12_A0101_SEQ_0004
Figure 12_A0101_SEQ_0005
Figure 12_A0101_SEQ_0006
Figure 12_A0101_SEQ_0007
Figure 12_A0101_SEQ_0008
Figure 12_A0101_SEQ_0009
Figure 12_A0101_SEQ_0010
Figure 12_A0101_SEQ_0011
Figure 12_A0101_SEQ_0012
Figure 12_A0101_SEQ_0013
Figure 12_A0101_SEQ_0014
Figure 12_A0101_SEQ_0015
Figure 12_A0101_SEQ_0016
Figure 12_A0101_SEQ_0017
Figure 12_A0101_SEQ_0018
Figure 12_A0101_SEQ_0019
Figure 12_A0101_SEQ_0020
Figure 12_A0101_SEQ_0021
Figure 12_A0101_SEQ_0022
Figure 12_A0101_SEQ_0023
Figure 12_A0101_SEQ_0024
Figure 12_A0101_SEQ_0025
Figure 12_A0101_SEQ_0026
Figure 12_A0101_SEQ_0027
Figure 12_A0101_SEQ_0028
Figure 12_A0101_SEQ_0029
Figure 12_A0101_SEQ_0030
Figure 12_A0101_SEQ_0031
Figure 12_A0101_SEQ_0032
Figure 12_A0101_SEQ_0033
Figure 12_A0101_SEQ_0034
Figure 12_A0101_SEQ_0035
Figure 12_A0101_SEQ_0036
Figure 12_A0101_SEQ_0037
Figure 12_A0101_SEQ_0038
Figure 12_A0101_SEQ_0039
Figure 12_A0101_SEQ_0040
Figure 12_A0101_SEQ_0041
Figure 12_A0101_SEQ_0042
Figure 12_A0101_SEQ_0043
Figure 12_A0101_SEQ_0044
Figure 12_A0101_SEQ_0045
Figure 12_A0101_SEQ_0046
Figure 12_A0101_SEQ_0047
Figure 12_A0101_SEQ_0048
Figure 12_A0101_SEQ_0049
Figure 12_A0101_SEQ_0050
Figure 12_A0101_SEQ_0051
Figure 12_A0101_SEQ_0052
Figure 12_A0101_SEQ_0053
Figure 12_A0101_SEQ_0054
Figure 12_A0101_SEQ_0055
Figure 12_A0101_SEQ_0056
Figure 12_A0101_SEQ_0057
Figure 12_A0101_SEQ_0058
Figure 12_A0101_SEQ_0059
Figure 12_A0101_SEQ_0060
Figure 12_A0101_SEQ_0061
Figure 12_A0101_SEQ_0062
Figure 12_A0101_SEQ_0063
Figure 12_A0101_SEQ_0064
Figure 12_A0101_SEQ_0065
Figure 12_A0101_SEQ_0066
Figure 12_A0101_SEQ_0067
Figure 12_A0101_SEQ_0068
Figure 12_A0101_SEQ_0069
Figure 12_A0101_SEQ_0070
Figure 12_A0101_SEQ_0071
Figure 12_A0101_SEQ_0072
Figure 12_A0101_SEQ_0073
Figure 12_A0101_SEQ_0074
Figure 12_A0101_SEQ_0075
Figure 12_A0101_SEQ_0076
Figure 12_A0101_SEQ_0077
Figure 12_A0101_SEQ_0078
Figure 12_A0101_SEQ_0079
Figure 12_A0101_SEQ_0080
Figure 12_A0101_SEQ_0081
Figure 12_A0101_SEQ_0082
Figure 12_A0101_SEQ_0083
Figure 12_A0101_SEQ_0084
Figure 12_A0101_SEQ_0085
Figure 12_A0101_SEQ_0086
Figure 12_A0101_SEQ_0087
Figure 12_A0101_SEQ_0088
Figure 12_A0101_SEQ_0089
Figure 12_A0101_SEQ_0090
Figure 12_A0101_SEQ_0091
Figure 12_A0101_SEQ_0092
Figure 12_A0101_SEQ_0093
Figure 12_A0101_SEQ_0094
Figure 12_A0101_SEQ_0095
Figure 12_A0101_SEQ_0096
Figure 12_A0101_SEQ_0097
Figure 12_A0101_SEQ_0098
Figure 12_A0101_SEQ_0099
Figure 12_A0101_SEQ_0100
Figure 12_A0101_SEQ_0101
Figure 12_A0101_SEQ_0102
Figure 12_A0101_SEQ_0103
Figure 12_A0101_SEQ_0104
Figure 12_A0101_SEQ_0105
Figure 12_A0101_SEQ_0106
Figure 12_A0101_SEQ_0107
Figure 12_A0101_SEQ_0108
Figure 12_A0101_SEQ_0109
Figure 12_A0101_SEQ_0110
Figure 12_A0101_SEQ_0111
Figure 12_A0101_SEQ_0112
Figure 12_A0101_SEQ_0113
Figure 12_A0101_SEQ_0114
Figure 12_A0101_SEQ_0115
Figure 12_A0101_SEQ_0116
Figure 12_A0101_SEQ_0117
Figure 12_A0101_SEQ_0118
Figure 12_A0101_SEQ_0119
Figure 12_A0101_SEQ_0120
Figure 12_A0101_SEQ_0121
Figure 12_A0101_SEQ_0122
Figure 12_A0101_SEQ_0123
Figure 12_A0101_SEQ_0124
Figure 12_A0101_SEQ_0125
Figure 12_A0101_SEQ_0126
Figure 12_A0101_SEQ_0127
Figure 12_A0101_SEQ_0128
Figure 12_A0101_SEQ_0129
Figure 12_A0101_SEQ_0130
Figure 12_A0101_SEQ_0131
Figure 12_A0101_SEQ_0132
Figure 12_A0101_SEQ_0133
Figure 12_A0101_SEQ_0134
Figure 12_A0101_SEQ_0135
Figure 12_A0101_SEQ_0136
Figure 12_A0101_SEQ_0137
Figure 12_A0101_SEQ_0138
Figure 12_A0101_SEQ_0139
Figure 12_A0101_SEQ_0140
Figure 12_A0101_SEQ_0141
Figure 12_A0101_SEQ_0142
Figure 12_A0101_SEQ_0143
Figure 12_A0101_SEQ_0144
Figure 12_A0101_SEQ_0145
Figure 12_A0101_SEQ_0146
Figure 12_A0101_SEQ_0147
Figure 12_A0101_SEQ_0148
Figure 12_A0101_SEQ_0149
Figure 12_A0101_SEQ_0150
Figure 12_A0101_SEQ_0151
Figure 12_A0101_SEQ_0152
Figure 12_A0101_SEQ_0153
Figure 12_A0101_SEQ_0154
Figure 12_A0101_SEQ_0155
Figure 12_A0101_SEQ_0156
Figure 12_A0101_SEQ_0157
Figure 12_A0101_SEQ_0158
Figure 12_A0101_SEQ_0159
Figure 12_A0101_SEQ_0160
Figure 12_A0101_SEQ_0161
Figure 12_A0101_SEQ_0162
Figure 12_A0101_SEQ_0163
Figure 12_A0101_SEQ_0164
Figure 12_A0101_SEQ_0165
Figure 12_A0101_SEQ_0166
Figure 12_A0101_SEQ_0167
Figure 12_A0101_SEQ_0168
Figure 12_A0101_SEQ_0169
Figure 12_A0101_SEQ_0170
Figure 12_A0101_SEQ_0171
Figure 12_A0101_SEQ_0172
Figure 12_A0101_SEQ_0173
Figure 12_A0101_SEQ_0174
Figure 12_A0101_SEQ_0175
Figure 12_A0101_SEQ_0176
Figure 12_A0101_SEQ_0177
Figure 12_A0101_SEQ_0178
Figure 12_A0101_SEQ_0179
Figure 12_A0101_SEQ_0180
Figure 12_A0101_SEQ_0181
Figure 12_A0101_SEQ_0182
Figure 12_A0101_SEQ_0183
Figure 12_A0101_SEQ_0184
Figure 12_A0101_SEQ_0185
Figure 12_A0101_SEQ_0186
Figure 12_A0101_SEQ_0187
Figure 12_A0101_SEQ_0188
Figure 12_A0101_SEQ_0189
Figure 12_A0101_SEQ_0190
Figure 12_A0101_SEQ_0191
Figure 12_A0101_SEQ_0192
Figure 12_A0101_SEQ_0193
Figure 12_A0101_SEQ_0194
Figure 12_A0101_SEQ_0195
Figure 12_A0101_SEQ_0196
Figure 12_A0101_SEQ_0197
Figure 12_A0101_SEQ_0198
Figure 12_A0101_SEQ_0199
Figure 12_A0101_SEQ_0200
Figure 12_A0101_SEQ_0201
Figure 12_A0101_SEQ_0202
Figure 12_A0101_SEQ_0203
Figure 12_A0101_SEQ_0204
Figure 12_A0101_SEQ_0205
Figure 12_A0101_SEQ_0206
Figure 12_A0101_SEQ_0207
Figure 12_A0101_SEQ_0208
Figure 12_A0101_SEQ_0209
Figure 12_A0101_SEQ_0210
Figure 12_A0101_SEQ_0211
Figure 12_A0101_SEQ_0212
Figure 12_A0101_SEQ_0213
Figure 12_A0101_SEQ_0214
Figure 12_A0101_SEQ_0215
Figure 12_A0101_SEQ_0216
Figure 12_A0101_SEQ_0217
Figure 12_A0101_SEQ_0218
Figure 12_A0101_SEQ_0219
Figure 12_A0101_SEQ_0220
Figure 12_A0101_SEQ_0221
Figure 12_A0101_SEQ_0222
Figure 12_A0101_SEQ_0223
Figure 12_A0101_SEQ_0224
Figure 12_A0101_SEQ_0225
Figure 12_A0101_SEQ_0226
Figure 12_A0101_SEQ_0227
Figure 12_A0101_SEQ_0228
Figure 12_A0101_SEQ_0229
Figure 12_A0101_SEQ_0230
Figure 12_A0101_SEQ_0231
Figure 12_A0101_SEQ_0232
Figure 12_A0101_SEQ_0233
Figure 12_A0101_SEQ_0234
Figure 12_A0101_SEQ_0235
Figure 12_A0101_SEQ_0236
Figure 12_A0101_SEQ_0237
Figure 12_A0101_SEQ_0238
Figure 12_A0101_SEQ_0239
Figure 12_A0101_SEQ_0240
Figure 12_A0101_SEQ_0241
Figure 12_A0101_SEQ_0242
Figure 12_A0101_SEQ_0243
Figure 12_A0101_SEQ_0244
Figure 12_A0101_SEQ_0245
Figure 12_A0101_SEQ_0246
Figure 12_A0101_SEQ_0247
Figure 12_A0101_SEQ_0248
Figure 12_A0101_SEQ_0249
Figure 12_A0101_SEQ_0250
Figure 12_A0101_SEQ_0251
Figure 12_A0101_SEQ_0252
Figure 12_A0101_SEQ_0253
Figure 12_A0101_SEQ_0254
Figure 12_A0101_SEQ_0255
Figure 12_A0101_SEQ_0256
Figure 12_A0101_SEQ_0257
Figure 12_A0101_SEQ_0258
Figure 12_A0101_SEQ_0259
Figure 12_A0101_SEQ_0260
Figure 12_A0101_SEQ_0261
Figure 12_A0101_SEQ_0262
Figure 12_A0101_SEQ_0263
Figure 12_A0101_SEQ_0264
Figure 12_A0101_SEQ_0265
Figure 12_A0101_SEQ_0266
Figure 12_A0101_SEQ_0267
Figure 12_A0101_SEQ_0268
Figure 12_A0101_SEQ_0269
Figure 12_A0101_SEQ_0270
Figure 12_A0101_SEQ_0271
Figure 12_A0101_SEQ_0272
Figure 12_A0101_SEQ_0273
Figure 12_A0101_SEQ_0274
Figure 12_A0101_SEQ_0275
Figure 12_A0101_SEQ_0276
Figure 12_A0101_SEQ_0277
Figure 12_A0101_SEQ_0278
Figure 12_A0101_SEQ_0279
Figure 12_A0101_SEQ_0280
Figure 12_A0101_SEQ_0281
Figure 12_A0101_SEQ_0282
Figure 12_A0101_SEQ_0283
Figure 12_A0101_SEQ_0284
Figure 12_A0101_SEQ_0285
Figure 12_A0101_SEQ_0286
Figure 12_A0101_SEQ_0287
Figure 12_A0101_SEQ_0288
Figure 12_A0101_SEQ_0289
Figure 12_A0101_SEQ_0290
Figure 12_A0101_SEQ_0291
Figure 12_A0101_SEQ_0292
Figure 12_A0101_SEQ_0293
Figure 12_A0101_SEQ_0294
Figure 12_A0101_SEQ_0295
Figure 12_A0101_SEQ_0296
Figure 12_A0101_SEQ_0297
Figure 12_A0101_SEQ_0298
Figure 12_A0101_SEQ_0299
Figure 12_A0101_SEQ_0300
Figure 12_A0101_SEQ_0301
Figure 12_A0101_SEQ_0302
Figure 12_A0101_SEQ_0303
Figure 12_A0101_SEQ_0304
Figure 12_A0101_SEQ_0305
Figure 12_A0101_SEQ_0306
Figure 12_A0101_SEQ_0307
Figure 12_A0101_SEQ_0308
Figure 12_A0101_SEQ_0309
Figure 12_A0101_SEQ_0310
Figure 12_A0101_SEQ_0311
Figure 12_A0101_SEQ_0312
Figure 12_A0101_SEQ_0313
Figure 12_A0101_SEQ_0314
Figure 12_A0101_SEQ_0315
Figure 12_A0101_SEQ_0316
Figure 12_A0101_SEQ_0317
Figure 12_A0101_SEQ_0318
Figure 12_A0101_SEQ_0319
Figure 12_A0101_SEQ_0320
Figure 12_A0101_SEQ_0321
Figure 12_A0101_SEQ_0322
Figure 12_A0101_SEQ_0323
Figure 12_A0101_SEQ_0324
Figure 12_A0101_SEQ_0325
Figure 12_A0101_SEQ_0326
Figure 12_A0101_SEQ_0327
Figure 12_A0101_SEQ_0328
Figure 12_A0101_SEQ_0329
Figure 12_A0101_SEQ_0330
Figure 12_A0101_SEQ_0331
Figure 12_A0101_SEQ_0332
Figure 12_A0101_SEQ_0333
Figure 12_A0101_SEQ_0334
Figure 12_A0101_SEQ_0335
Figure 12_A0101_SEQ_0336
Figure 12_A0101_SEQ_0337
Figure 12_A0101_SEQ_0338
Figure 12_A0101_SEQ_0339
Figure 12_A0101_SEQ_0340
Figure 12_A0101_SEQ_0341
Figure 12_A0101_SEQ_0342
Figure 12_A0101_SEQ_0343
Figure 12_A0101_SEQ_0344
Figure 12_A0101_SEQ_0345
Figure 12_A0101_SEQ_0346
Figure 12_A0101_SEQ_0347
Figure 12_A0101_SEQ_0348
Figure 12_A0101_SEQ_0349
Figure 12_A0101_SEQ_0350
Figure 12_A0101_SEQ_0351
Figure 12_A0101_SEQ_0352
Figure 12_A0101_SEQ_0353
Figure 12_A0101_SEQ_0354
Figure 12_A0101_SEQ_0355
Figure 12_A0101_SEQ_0356
Figure 12_A0101_SEQ_0357
Figure 12_A0101_SEQ_0358
Figure 12_A0101_SEQ_0359
Figure 12_A0101_SEQ_0360
Figure 12_A0101_SEQ_0361
Figure 12_A0101_SEQ_0362
Figure 12_A0101_SEQ_0363
Figure 12_A0101_SEQ_0364
Figure 12_A0101_SEQ_0365
Figure 12_A0101_SEQ_0366
Figure 12_A0101_SEQ_0367
Figure 12_A0101_SEQ_0368
Figure 12_A0101_SEQ_0369
Figure 12_A0101_SEQ_0370
Figure 12_A0101_SEQ_0371
Figure 12_A0101_SEQ_0372
Figure 12_A0101_SEQ_0373
Figure 12_A0101_SEQ_0374
Figure 12_A0101_SEQ_0375
Figure 12_A0101_SEQ_0376
Figure 12_A0101_SEQ_0377
Figure 12_A0101_SEQ_0378
Figure 12_A0101_SEQ_0379
Figure 12_A0101_SEQ_0380
Figure 12_A0101_SEQ_0381
Figure 12_A0101_SEQ_0382
Figure 12_A0101_SEQ_0383
Figure 12_A0101_SEQ_0384
Figure 12_A0101_SEQ_0385
Figure 12_A0101_SEQ_0386
Figure 12_A0101_SEQ_0387
Figure 12_A0101_SEQ_0388
Figure 12_A0101_SEQ_0389
Figure 12_A0101_SEQ_0390
Figure 12_A0101_SEQ_0391
Figure 12_A0101_SEQ_0392
Figure 12_A0101_SEQ_0393
Figure 12_A0101_SEQ_0394
Figure 12_A0101_SEQ_0395
Figure 12_A0101_SEQ_0396
Figure 12_A0101_SEQ_0397
Figure 12_A0101_SEQ_0398
Figure 12_A0101_SEQ_0399
Figure 12_A0101_SEQ_0400
Figure 12_A0101_SEQ_0401
Figure 12_A0101_SEQ_0402
Figure 12_A0101_SEQ_0403
Figure 12_A0101_SEQ_0404
Figure 12_A0101_SEQ_0405
Figure 12_A0101_SEQ_0406
Figure 12_A0101_SEQ_0407
Figure 12_A0101_SEQ_0408
Figure 12_A0101_SEQ_0409
Figure 12_A0101_SEQ_0410
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Figure 12_A0101_SEQ_0412
Figure 12_A0101_SEQ_0413
Figure 12_A0101_SEQ_0414
Figure 12_A0101_SEQ_0415
Figure 12_A0101_SEQ_0416
Figure 12_A0101_SEQ_0417
Figure 12_A0101_SEQ_0418
Figure 12_A0101_SEQ_0419
Figure 12_A0101_SEQ_0420
Figure 12_A0101_SEQ_0421
Figure 12_A0101_SEQ_0422
Figure 12_A0101_SEQ_0423
Figure 12_A0101_SEQ_0424
Figure 12_A0101_SEQ_0425
Figure 12_A0101_SEQ_0426
Figure 12_A0101_SEQ_0427
Figure 12_A0101_SEQ_0428
Figure 12_A0101_SEQ_0429
Figure 12_A0101_SEQ_0430
Figure 12_A0101_SEQ_0431
Figure 12_A0101_SEQ_0432
Figure 12_A0101_SEQ_0433
Figure 12_A0101_SEQ_0434
Figure 12_A0101_SEQ_0435
Figure 12_A0101_SEQ_0436
Figure 12_A0101_SEQ_0437
Figure 12_A0101_SEQ_0438
Figure 12_A0101_SEQ_0439
Figure 12_A0101_SEQ_0440
Figure 12_A0101_SEQ_0441
Figure 12_A0101_SEQ_0442
Figure 12_A0101_SEQ_0443
Figure 12_A0101_SEQ_0444
Figure 12_A0101_SEQ_0445
Figure 12_A0101_SEQ_0446
Figure 12_A0101_SEQ_0447
Figure 12_A0101_SEQ_0448
Figure 12_A0101_SEQ_0449
Figure 12_A0101_SEQ_0450
Figure 12_A0101_SEQ_0451
Figure 12_A0101_SEQ_0452
Figure 12_A0101_SEQ_0453
Figure 12_A0101_SEQ_0454
Figure 12_A0101_SEQ_0455
Figure 12_A0101_SEQ_0456
Figure 12_A0101_SEQ_0457
Figure 12_A0101_SEQ_0458
Figure 12_A0101_SEQ_0459
Figure 12_A0101_SEQ_0460
Figure 12_A0101_SEQ_0461
Figure 12_A0101_SEQ_0462
Figure 12_A0101_SEQ_0463
Figure 12_A0101_SEQ_0464
Figure 12_A0101_SEQ_0465
Figure 12_A0101_SEQ_0466
Figure 12_A0101_SEQ_0467
Figure 12_A0101_SEQ_0468
Figure 12_A0101_SEQ_0469
Figure 12_A0101_SEQ_0470
Figure 12_A0101_SEQ_0471
Figure 12_A0101_SEQ_0472
Figure 12_A0101_SEQ_0473
Figure 12_A0101_SEQ_0474
Figure 12_A0101_SEQ_0475
Figure 12_A0101_SEQ_0476
Figure 12_A0101_SEQ_0477
Figure 12_A0101_SEQ_0478
Figure 12_A0101_SEQ_0479
Figure 12_A0101_SEQ_0480
Figure 12_A0101_SEQ_0481
Figure 12_A0101_SEQ_0482
Figure 12_A0101_SEQ_0483
Figure 12_A0101_SEQ_0484
Figure 12_A0101_SEQ_0485
Figure 12_A0101_SEQ_0486
Figure 12_A0101_SEQ_0487
Figure 12_A0101_SEQ_0488
Figure 12_A0101_SEQ_0489
Figure 12_A0101_SEQ_0490
Figure 12_A0101_SEQ_0491
Figure 12_A0101_SEQ_0492
Figure 12_A0101_SEQ_0493
Figure 12_A0101_SEQ_0494
Figure 12_A0101_SEQ_0495
Figure 12_A0101_SEQ_0496
Figure 12_A0101_SEQ_0497
Figure 12_A0101_SEQ_0498
Figure 12_A0101_SEQ_0499
Figure 12_A0101_SEQ_0500
Figure 12_A0101_SEQ_0501
Figure 12_A0101_SEQ_0502
Figure 12_A0101_SEQ_0503
Figure 12_A0101_SEQ_0504
Figure 12_A0101_SEQ_0505
Figure 12_A0101_SEQ_0506
Figure 12_A0101_SEQ_0507
Figure 12_A0101_SEQ_0508
Figure 12_A0101_SEQ_0509
Figure 12_A0101_SEQ_0510
Figure 12_A0101_SEQ_0511
Figure 12_A0101_SEQ_0512
Figure 12_A0101_SEQ_0513
Figure 12_A0101_SEQ_0514
Figure 12_A0101_SEQ_0515
Figure 12_A0101_SEQ_0516
Figure 12_A0101_SEQ_0517
Figure 12_A0101_SEQ_0518
Figure 12_A0101_SEQ_0519
Figure 12_A0101_SEQ_0520
Figure 12_A0101_SEQ_0521
Figure 12_A0101_SEQ_0522
Figure 12_A0101_SEQ_0523
Figure 12_A0101_SEQ_0524
Figure 12_A0101_SEQ_0525
Figure 12_A0101_SEQ_0526
Figure 12_A0101_SEQ_0527
Figure 12_A0101_SEQ_0528
Figure 12_A0101_SEQ_0529
Figure 12_A0101_SEQ_0530
Figure 12_A0101_SEQ_0531
Figure 12_A0101_SEQ_0532
Figure 12_A0101_SEQ_0533
Figure 12_A0101_SEQ_0534
Figure 12_A0101_SEQ_0535
Figure 12_A0101_SEQ_0536
Figure 12_A0101_SEQ_0537
Figure 12_A0101_SEQ_0538
Figure 12_A0101_SEQ_0539
Figure 12_A0101_SEQ_0540
Figure 12_A0101_SEQ_0541
Figure 12_A0101_SEQ_0542
Figure 12_A0101_SEQ_0543
Figure 12_A0101_SEQ_0544
Figure 12_A0101_SEQ_0545
Figure 12_A0101_SEQ_0546
Figure 12_A0101_SEQ_0547
Figure 12_A0101_SEQ_0548
Figure 12_A0101_SEQ_0549
Figure 12_A0101_SEQ_0550
Figure 12_A0101_SEQ_0551
Figure 12_A0101_SEQ_0552
Figure 12_A0101_SEQ_0553
Figure 12_A0101_SEQ_0554
Figure 12_A0101_SEQ_0555
Figure 12_A0101_SEQ_0556
Figure 12_A0101_SEQ_0557
Figure 12_A0101_SEQ_0558
Figure 12_A0101_SEQ_0559
Figure 12_A0101_SEQ_0560
Figure 12_A0101_SEQ_0561
Figure 12_A0101_SEQ_0562
Figure 12_A0101_SEQ_0563
Figure 12_A0101_SEQ_0564
Figure 12_A0101_SEQ_0565
Figure 12_A0101_SEQ_0566
Figure 12_A0101_SEQ_0567
Figure 12_A0101_SEQ_0568
Figure 12_A0101_SEQ_0569
Figure 12_A0101_SEQ_0570
Figure 12_A0101_SEQ_0571
Figure 12_A0101_SEQ_0572
Figure 12_A0101_SEQ_0573
Figure 12_A0101_SEQ_0574
Figure 12_A0101_SEQ_0575
Figure 12_A0101_SEQ_0576
Figure 12_A0101_SEQ_0577
Figure 12_A0101_SEQ_0578
Figure 12_A0101_SEQ_0579
Figure 12_A0101_SEQ_0580
Figure 12_A0101_SEQ_0581
Figure 12_A0101_SEQ_0582
Figure 12_A0101_SEQ_0583
Figure 12_A0101_SEQ_0584
Figure 12_A0101_SEQ_0585
Figure 12_A0101_SEQ_0586
Figure 12_A0101_SEQ_0587
Figure 12_A0101_SEQ_0588
Figure 12_A0101_SEQ_0589
Figure 12_A0101_SEQ_0590
Figure 12_A0101_SEQ_0591
Figure 12_A0101_SEQ_0592
Figure 12_A0101_SEQ_0593
Figure 12_A0101_SEQ_0594
Figure 12_A0101_SEQ_0595
Figure 12_A0101_SEQ_0596
Figure 12_A0101_SEQ_0597
Figure 12_A0101_SEQ_0598
Figure 12_A0101_SEQ_0599
Figure 12_A0101_SEQ_0600
Figure 12_A0101_SEQ_0601
Figure 12_A0101_SEQ_0602
Figure 12_A0101_SEQ_0603
Figure 12_A0101_SEQ_0604
Figure 12_A0101_SEQ_0605
Figure 12_A0101_SEQ_0606
Figure 12_A0101_SEQ_0607
Figure 12_A0101_SEQ_0608
Figure 12_A0101_SEQ_0609
Figure 12_A0101_SEQ_0610
Figure 12_A0101_SEQ_0611
Figure 12_A0101_SEQ_0612
Figure 12_A0101_SEQ_0613
Figure 12_A0101_SEQ_0614
Figure 12_A0101_SEQ_0615
Figure 12_A0101_SEQ_0616
Figure 12_A0101_SEQ_0617
Figure 12_A0101_SEQ_0618
Figure 12_A0101_SEQ_0619
Figure 12_A0101_SEQ_0620
Figure 12_A0101_SEQ_0621
Figure 12_A0101_SEQ_0622
Figure 12_A0101_SEQ_0623
Figure 12_A0101_SEQ_0624
Figure 12_A0101_SEQ_0625
Figure 12_A0101_SEQ_0626
Figure 12_A0101_SEQ_0627
Figure 12_A0101_SEQ_0628
Figure 12_A0101_SEQ_0629
Figure 12_A0101_SEQ_0630
Figure 12_A0101_SEQ_0631
Figure 12_A0101_SEQ_0632
Figure 12_A0101_SEQ_0633
Figure 12_A0101_SEQ_0634
Figure 12_A0101_SEQ_0635
Figure 12_A0101_SEQ_0636
Figure 12_A0101_SEQ_0637
Figure 12_A0101_SEQ_0638
Figure 12_A0101_SEQ_0639
Figure 12_A0101_SEQ_0640
Figure 12_A0101_SEQ_0641
Figure 12_A0101_SEQ_0642
Figure 12_A0101_SEQ_0643
Figure 12_A0101_SEQ_0644
Figure 12_A0101_SEQ_0645
Figure 12_A0101_SEQ_0646
Figure 12_A0101_SEQ_0647
Figure 12_A0101_SEQ_0648
Figure 12_A0101_SEQ_0649
Figure 12_A0101_SEQ_0650
Figure 12_A0101_SEQ_0651
Figure 12_A0101_SEQ_0652
Figure 12_A0101_SEQ_0653
Figure 12_A0101_SEQ_0654
Figure 12_A0101_SEQ_0655
Figure 12_A0101_SEQ_0656
Figure 12_A0101_SEQ_0657
Figure 12_A0101_SEQ_0658
Figure 12_A0101_SEQ_0659
Figure 12_A0101_SEQ_0660
Figure 12_A0101_SEQ_0661
Figure 12_A0101_SEQ_0662
Figure 12_A0101_SEQ_0663
Figure 12_A0101_SEQ_0664
Figure 12_A0101_SEQ_0665
Figure 12_A0101_SEQ_0666
Figure 12_A0101_SEQ_0667
Figure 12_A0101_SEQ_0668
Figure 12_A0101_SEQ_0669
Figure 12_A0101_SEQ_0670
Figure 12_A0101_SEQ_0671
Figure 12_A0101_SEQ_0672
Figure 12_A0101_SEQ_0673
Figure 12_A0101_SEQ_0674
Figure 12_A0101_SEQ_0675
Figure 12_A0101_SEQ_0676
Figure 12_A0101_SEQ_0677
Figure 12_A0101_SEQ_0678
Figure 12_A0101_SEQ_0679
Figure 12_A0101_SEQ_0680
Figure 12_A0101_SEQ_0681
Figure 12_A0101_SEQ_0682
Figure 12_A0101_SEQ_0683
Figure 12_A0101_SEQ_0684
Figure 12_A0101_SEQ_0685
Figure 12_A0101_SEQ_0686
Figure 12_A0101_SEQ_0687
Figure 12_A0101_SEQ_0688
Figure 12_A0101_SEQ_0689
Figure 12_A0101_SEQ_0690
Figure 12_A0101_SEQ_0691
Figure 12_A0101_SEQ_0692
Figure 12_A0101_SEQ_0693
Figure 12_A0101_SEQ_0694
Figure 12_A0101_SEQ_0695
Figure 12_A0101_SEQ_0696
Figure 12_A0101_SEQ_0697
Figure 12_A0101_SEQ_0698
Figure 12_A0101_SEQ_0699
Figure 12_A0101_SEQ_0700
Figure 12_A0101_SEQ_0701
Figure 12_A0101_SEQ_0702
Figure 12_A0101_SEQ_0703
Figure 12_A0101_SEQ_0704
Figure 12_A0101_SEQ_0705
Figure 12_A0101_SEQ_0706
Figure 12_A0101_SEQ_0707
Figure 12_A0101_SEQ_0708
Figure 12_A0101_SEQ_0709
Figure 12_A0101_SEQ_0710
Figure 12_A0101_SEQ_0711
Figure 12_A0101_SEQ_0712
Figure 12_A0101_SEQ_0713
Figure 12_A0101_SEQ_0714
Figure 12_A0101_SEQ_0715
Figure 12_A0101_SEQ_0716
Figure 12_A0101_SEQ_0717
Figure 12_A0101_SEQ_0718
Figure 12_A0101_SEQ_0719
Figure 12_A0101_SEQ_0720
Figure 12_A0101_SEQ_0721
Figure 12_A0101_SEQ_0722
Figure 12_A0101_SEQ_0723
Figure 12_A0101_SEQ_0724
Figure 12_A0101_SEQ_0725
Figure 12_A0101_SEQ_0726
Figure 12_A0101_SEQ_0727
Figure 12_A0101_SEQ_0728
Figure 12_A0101_SEQ_0729
Figure 12_A0101_SEQ_0730
Figure 12_A0101_SEQ_0731
Figure 12_A0101_SEQ_0732
Figure 12_A0101_SEQ_0733
Figure 12_A0101_SEQ_0734
Figure 12_A0101_SEQ_0735
Figure 12_A0101_SEQ_0736
Figure 12_A0101_SEQ_0737
Figure 12_A0101_SEQ_0738
Figure 12_A0101_SEQ_0739
Figure 12_A0101_SEQ_0740
Figure 12_A0101_SEQ_0741
Figure 12_A0101_SEQ_0742
Figure 12_A0101_SEQ_0743
Figure 12_A0101_SEQ_0744
Figure 12_A0101_SEQ_0745
Figure 12_A0101_SEQ_0746
Figure 12_A0101_SEQ_0747
Figure 12_A0101_SEQ_0748
Figure 12_A0101_SEQ_0749
Figure 12_A0101_SEQ_0750
Figure 12_A0101_SEQ_0751
Figure 12_A0101_SEQ_0752
Figure 12_A0101_SEQ_0753
Figure 12_A0101_SEQ_0754
Figure 12_A0101_SEQ_0755
Figure 12_A0101_SEQ_0756
Figure 12_A0101_SEQ_0757
Figure 12_A0101_SEQ_0758
Figure 12_A0101_SEQ_0759
Figure 12_A0101_SEQ_0760
Figure 12_A0101_SEQ_0761
Figure 12_A0101_SEQ_0762
Figure 12_A0101_SEQ_0763
Figure 12_A0101_SEQ_0764
Figure 12_A0101_SEQ_0765
Figure 12_A0101_SEQ_0766
Figure 12_A0101_SEQ_0767
Figure 12_A0101_SEQ_0768
Figure 12_A0101_SEQ_0769
Figure 12_A0101_SEQ_0770
Figure 12_A0101_SEQ_0771
Figure 12_A0101_SEQ_0772
Figure 12_A0101_SEQ_0773
Figure 12_A0101_SEQ_0774
Figure 12_A0101_SEQ_0775
Figure 12_A0101_SEQ_0776
Figure 12_A0101_SEQ_0777
Figure 12_A0101_SEQ_0778
Figure 12_A0101_SEQ_0779
Figure 12_A0101_SEQ_0780
Figure 12_A0101_SEQ_0781
Figure 12_A0101_SEQ_0782
Figure 12_A0101_SEQ_0783
Figure 12_A0101_SEQ_0784
Figure 12_A0101_SEQ_0785
Figure 12_A0101_SEQ_0786
Figure 12_A0101_SEQ_0787
Figure 12_A0101_SEQ_0788
Figure 12_A0101_SEQ_0789
Figure 12_A0101_SEQ_0790
Figure 12_A0101_SEQ_0791
Figure 12_A0101_SEQ_0792
Figure 12_A0101_SEQ_0793
Figure 12_A0101_SEQ_0794
Figure 12_A0101_SEQ_0795
Figure 12_A0101_SEQ_0796
Figure 12_A0101_SEQ_0797
Figure 12_A0101_SEQ_0798
Figure 12_A0101_SEQ_0799
Figure 12_A0101_SEQ_0800
Figure 12_A0101_SEQ_0801
Figure 12_A0101_SEQ_0802
Figure 12_A0101_SEQ_0803
Figure 12_A0101_SEQ_0804
Figure 12_A0101_SEQ_0805
Figure 12_A0101_SEQ_0806
Figure 12_A0101_SEQ_0807
Figure 12_A0101_SEQ_0808
Figure 12_A0101_SEQ_0809
Figure 12_A0101_SEQ_0810
Figure 12_A0101_SEQ_0811
Figure 12_A0101_SEQ_0812
Figure 12_A0101_SEQ_0813
Figure 12_A0101_SEQ_0814
Figure 12_A0101_SEQ_0815
Figure 12_A0101_SEQ_0816
Figure 12_A0101_SEQ_0817
Figure 12_A0101_SEQ_0818
Figure 12_A0101_SEQ_0819
Figure 12_A0101_SEQ_0820
Figure 12_A0101_SEQ_0821
Figure 12_A0101_SEQ_0822
Figure 12_A0101_SEQ_0823

Claims (27)

  1. 一種下式化合物： X1 X2 EGTX6 TSDX10 X11 X12 X13 LDX16 X17 AQX20 X21 X22 IX24 X25 LIX28 GX30 (SEQ ID NO:505) 或其醫藥學上可接受之鹽， 其中 X1 選自由Y及R1 Y組成之群； R1 為N端胺基之Ac修飾； X2 為Aib； X6 選自由αMeF及αMeF(2F)組成之群； X10 選自由4Pal、Y、αMeF、αMeF(2F)、αMeL、αMeV、Ac4c、Ac5c、Ac6c、Bip、1Nal、2Nal、OMeY、hTyr、Nle、V、4CPhe、ChG、ChA、Bzt、2FA、4TAA、2TA、3TA及KZ1 組成之群； X11 選自由S、αMeS、Aib、G、Dap、Ac5c及Tle組成之群； X12 選自由I及KZ1 組成之群； X13 選自由αMeL及αMeF組成之群； X16 為Orn； X17 選自由Q、I及KZ1 組成之群； X20 選自由Aib、Orn、4Pal、αMeF、Ac5c及Ac6c組成之群； X21 選自由E、KZ1 、G、Orn及4Pal組成之群； X22 選自由F、2ClPhe、3ClPhe、2FPhe、3FPhe、3,5FPhe、1Nal、2Nal、αMeF(2F)、ChA、Bzt及αMeF組成之群； X24 選自由D-Glu、E、G及KZ1 組成之群； X25 選自由Y、αMeY、αMeF及KZ1 組成之群； X28 選自由E、Orn及KZ1 組成之群； X30 選自由G、Orn、KZ1 、K(Z1 )R6 、OrnR2 及GR2 組成之群； R2 選自由X31 、X31 SSG (SEQ ID NO:5)、X31 SSG-R3 (SEQ ID NO:6)、X31 SSGX35 PPPX39 (SEQ ID NO:7)、X31 SSGX35 PPPX39 R3 (SEQ ID NO:8)、X31 SSGX35 PPPX39 X40 (SEQ ID NO:9)、X31 SSGX35 PPPX39 X40 R3 (SEQ ID NO:10)及c端基團之修飾組成之群，其中該修飾為NH2 ； R6 選自由PSSG (SEQ ID NO:506)、PSSG-R3 (SEQ ID NO:507)、PSSGX35 PPPX39 (SEQ ID NO:508)、PSSGX35 PPPX39 R3 (SEQ ID NO:509)、PSSGX35 PPPX39 X40 (SEQ ID NO:510)、PSSGX35 PPPX39 X40 R3 (SEQ ID NO:511)及c端基團之修飾組成之群，其中該修飾為NH2 ； X31 選自由P及KZ1 組成之群； X35 選自由A及Orn組成之群； X39 選自由S及Orn組成之群； X40 為KZ1 ； R3 為C端基團之修飾，其中該修飾為NH2 ； 其中X10 、X12 、X17 、X21 、X24 、X25 、X28 、X30 、X31 及X40 中之兩者且僅兩者為KZ1 或K(Z1 )R6 ； Z1 選自由R5 及-R4 R5 組成之群； R4 為連接子；且 R5 為脂肪酸；或 其醫藥學上可接受之鹽。
  2. 如請求項1之化合物或其醫藥學上可接受之鹽，其中 X30 選自由G、Orn、KZ1 及GR2 組成之群；及 R2 選自由X31 SSG (SEQ ID NO:5)、X31 SSG-R3 (SEQ ID NO:6)、X31 SSGX35 PPPX39 (SEQ ID NO:7)、X31 SSGX35 PPPX39 R3 (SEQ ID NO:8)、X31 SSGX35 PPPX39 X40 (SEQ ID NO:9)、X31 SSGX35 PPPX39 X40 R3 (SEQ ID NO:10)及c端基團之修飾組成之群，其中該修飾為NH2 。
  3. 如請求項1或2之化合物或其醫藥學上可接受之鹽，其中該Z1 為-R4 R5 。
  4. 如請求項1或2之化合物或其醫藥學上可接受之鹽，其中該R5 選自由以下組成之群：-CO-(CH2 )12 -CO2 H、CO-(CH2 )14 -CO2 H、-CO-(CH2 )10 -CO2 H、-(10-(4-羧基苯氧基)癸醯基)、-(4-(4-碘苯基)丁醯基)、-(4-(4-三級-丁基苯基)丁醯基)、-CO-(CH2 )14 -CH3 、-CO-(CH2 )12 -CH3 、-CO-(CH2 )10 -CH3 、-(7-(4-羧基苯氧基)庚醯基)、-(11-(4-羧基苯氧基)十一醯基)、-(12-(4-羧基苯氧基)十二醯基)及-(8-(4-羧基苯氧基)辛醯基)。
  5. 如請求項1或2之化合物或其醫藥學上可接受之鹽，其中該R5 選自由以下組成之群： -CO-(CH2 )12 -CO2 H、-CO-(CH2 )10 -CO2 H、-(10-(4-羧基苯氧基)癸醯基)、-(4-(4-碘苯基)丁醯基)、-(4-(4-三級-丁基苯基)丁醯基)、-CO-(CH2 )14 -CH3 、-CO-(CH2 )12 -CH3 、-CO-(CH2 )10 -CH3 、-(7-(4-羧基苯氧基)庚醯基)及-(8-(4-羧基苯氧基)辛醯基)。
  6. 如請求項1或2之化合物或其醫藥學上可接受之鹽，其中該R5 選自由以下組成之群： CO-(CH2 )14 -CO2 H、-(11-(4-羧基苯氧基)十一醯基)及-(12-(4-羧基苯氧基)十二醯基)。
  7. 如請求項1或2之化合物或其醫藥學上可接受之鹽，其中該R4 為-(εK)a1-(γ-Glu)a2-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)a3-(εK)b1-(γ-Glu)b2-； a1選自由0、1及2組成之群； a2選自由0、1及2組成之群； a3選自由0、1、2及3組成之群； b1為0或1；且 b2為0或1。
  8. 如請求項1或2之化合物或其醫藥學上可接受之鹽，其中該R4 選自由以下組成之群： -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)2 )-； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(εK)-； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(εK)-(γ-Glu)-； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(εK)-(γ-Glu)-； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-Trx-(γ-Glu)-； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -Trx-(γ-Glu)-； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-Aoc-； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-Aoc-(γ-Glu)-； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-Ahx-(γ-Glu)-； -PEG3-(γ-Glu)-； -PEG4-(γ-Glu)-； -PEG5-(γ-Glu)-； -PEG6-(γ-Glu)-； -Ahx-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-； -Aoc-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-； -(εK)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-； -(εK)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-； -(εK)-(γ-Glu)-； -(εK)-(γ-Glu)-(γ-Glu)-； -(γ-Glu)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -； -(εK)-(εK)-(γ-Glu)-； -(γ-Glu)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-； -(γ-Glu)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -；及 (2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-。
  9. 如請求項1或2之化合物或其醫藥學上可接受之鹽，其中該R4 選自由以下組成之群： -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(εK)-； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(εK)-(γ-Glu)-； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(εK)-(γ-Glu)-； -(εK)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-； -(εK)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-； -(εK)-(γ-Glu)-； -(εK)-(γ-Glu)-(γ-Glu)-； -(γ-Glu)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -； -(εK)-(εK)-(γ-Glu)-； -(γ-Glu)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-；及 -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(2-[2-(2-胺基-乙氧基-乙氧基]-乙醯基)-。
  10. 如請求項2之化合物或其醫藥學上可接受之鹽，其中該Z1 選自由以下組成之群： -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CO2 H； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基)； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(4-(4-碘苯基)丁醯基)； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(4-(4-三級-丁基苯基)丁醯基)； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )14 -CH3 ； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CH3 ； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 ； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(10-(4-羧基苯氧基)癸醯基)； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )12 -CO2 H； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基)； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )14 -CH3 ； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )10 -CH3 ； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-CO-(CH2 )12 -CO2 H； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-CO-(CH2 )14 -CH3 ； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(εK)-CO-(CH2 )12 -CO2 H； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(εK)-(γ-Glu)-CO-(CH2 )12 -CO2 H； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(εK)-(γ-Glu)-CO-(CH2 )12 -CO2 H； -(εK)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )12 -CO2 H； -(εK)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H； -(εK)-(γ-Glu)-CO-(CH2 )12 -CO2 H； -(εK)-(γ-Glu)-(γ-Glu)-CO-(CH2 )12 -CO2 H； -(γ-Glu)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H； -(εK)-(εK)-(γ-Glu)-CO-(CH2 )12 -CO2 H； -(γ-Glu)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-CO-(CH2 )12 -CO2 H； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-CO-(CH2 )12 -CO2 H； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(7-(4-羧基苯氧基)庚醯基)； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(8-(4-羧基苯氧基)辛醯基)； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(4-(4-三級-丁基苯基)丁醯基)； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(11-(4-羧基苯氧基)十一醯基)； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基)； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-CO-(CH2 )12 -CO2 H； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H； -PEG3-(γ-Glu)-CO-(CH2 )12 -CO2 H； -PEG4-(γ-Glu)-CO-(CH2 )12 -CO2 H； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-CO-(CH2 )10 -CH3 ； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(11-(4-羧基苯氧基)十一醯基； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )14 -CO2 H； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-Ahx-(γ-Glu)-CO-(CH2 )12 -CO2 H； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-Aoc-(γ-Glu)-CO-(CH2 )12 -CO2 H； -Ahx-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )12 -CO2 H； -Aoc-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )12 -CO2 H； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-Ahx-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基)； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-Aoc-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基)； -Ahx-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基)； -Aoc-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基)； -PEG4-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基)； -PEG3-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基)； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-Aoc-CO-(CH2 )12 -CO2 H； -PEG6-(γ-Glu)-CO-(CH2 )12 -CO2 H； -PEG5-(γ-Glu)-CO-(CH2 )12 -CO2 H； -PEG6-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基)； -PEG5-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基)； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -Trx-(γ-Glu)-CO-(CH2 )12 -CO2 H； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -Trx-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基)； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-Trx-(γ-Glu)-CO-(CH2 )12 -CO2 H； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-Trx-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基)； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)2 -CO-(CH2 )12 -CO2 H； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基2 -(γ-Glu)2 -(10-(4-羧基苯氧基)癸醯基)； -(γ-Glu)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H； -(γ-Glu)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基)； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )12 -CO2 H；及 -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基)。
  11. 如請求項10之化合物或其醫藥學上可接受之鹽，其中該Z1 選自由以下組成之群： -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CO2 H； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基)； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(4-(4-碘苯基)丁醯基)； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(4-(4-三級-丁基苯基)丁醯基)； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )14 -CH3 ； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CH3 ； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 ； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(10-(4-羧基苯氧基)癸醯基)； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )12 -CO2 H； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基)； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )14 -CH3 ； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )10 -CH3 ； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-CO-(CH2 )12 -CO2 H； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-CO-(CH2 )14 -CH3 ； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(εK)-CO-(CH2 )12 -CO2 H； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(εK)-(γ-Glu)-CO-(CH2 )12 -CO2 H； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(εK)-(γ-Glu)-CO-(CH2 )12 -CO2 H； -(εK)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )12 -CO2 H； -(εK)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H； -(εK)-(γ-Glu)-CO-(CH2 )12 -CO2 H； -(εK)-(γ-Glu)-(γ-Glu)-CO-(CH2 )12 -CO2 H； -(γ-Glu)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H； -(εK)-(εK)-(γ-Glu)-CO-(CH2 )12 -CO2 H； -(γ-Glu)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-CO-(CH2 )12 -CO2 H； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-CO-(CH2 )12 -CO2 H； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(7-(4-羧基苯氧基)庚醯基)； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(8-(4-羧基苯氧基)辛醯基)；及 -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(4-(4-三級-丁基苯基)丁醯基)。
  12. 如請求項10之化合物或其醫藥學上可接受之鹽，其中該Z1 選自由以下組成之群： -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(11-(4-羧基苯氧基)十一醯基)； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基)； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-CO-(CH2 )12 -CO2 H； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -CO-(CH2 )12 -CO2 H； -PEG3-(γ-Glu)-CO-(CH2 )12 -CO2 H； -PEG4-(γ-Glu)-CO-(CH2 )12 -CO2 H； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)3 -(γ-Glu)-CO-(CH2 )10 -CH3 ； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(11-(4-羧基苯氧基)十一醯基； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )14 -CO2 H； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-Ahx-(γ-Glu)-CO-(CH2 )12 -CO2 H； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-Aoc-(γ-Glu)-CO-(CH2 )12 -CO2 H； -Ahx-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )12 -CO2 H； -Aoc-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )12 -CO2 H； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-Ahx-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基)； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-Aoc-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基)； -Ahx-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基)； -Aoc-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基)； -PEG4-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基)； -PEG3-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基)； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-Aoc-CO-(CH2 )12 -CO2 H； -PEG6-(γ-Glu)-CO-(CH2 )12 -CO2 H； -PEG5-(γ-Glu)-CO-(CH2 )12 -CO2 H； -PEG6-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基)； -PEG5-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基)； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -Trx-(γ-Glu)-CO-(CH2 )12 -CO2 H； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -Trx-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基)； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-Trx-(γ-Glu)-CO-(CH2 )12 -CO2 H； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-Trx-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基)； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)2 -CO-(CH2 )12 -CO2 H； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基2 -(γ-Glu)2 -(10-(4-羧基苯氧基)癸醯基)； -(γ-Glu)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H； -(γ-Glu)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基)； -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-CO-(CH2 )12 -CO2 H；及 -(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)-(γ-Glu)-(10-(4-羧基苯氧基)癸醯基)。
  13. 如請求項1、2及10至12中任一項之化合物或其醫藥學上可接受之鹽，其中： X1 為Y； X6 為αMeF(2F)； X10 選自由4Pal、Y及KZ1 組成之群； X11 選自由S、αMeS及Aib組成之群； X12 為I； X13 為αMeL； X16 為Orn； X17 選自由I及KZ1 組成之群； X20 為Aib； X21 為E或KZ1 ； X22 選自由F及αMeF組成之群； X24 選自由D-Glu及KZ1 組成之群； X25 為αMeY； X28 選自由E及KZ1 組成之群； X30 選自由G及GR2 組成之群； R2 選自由X31 SSGX35 PPPX39 (SEQ ID NO:7)、X31 SSGX35 PPPX39 R3 (SEQ ID NO:8)及X31 SSGX35 PPPX39 X40 (SEQ ID NO:9)及c端基團之修飾組成之群，其中該修飾為NH2 ； 或其醫藥學上可接受之鹽。
  14. 如請求項1、2及10至12中任一項之化合物或其醫藥學上可接受之鹽，其中 X30 為GR2 ；及 R2 選自由X31 SSGX35 PPPX39 (SEQ ID NO:7)、X31 SSGX35 PPPX39 R3 (SEQ ID NO:8)及X31 SSGX35 PPPX39 X40 (SEQ ID NO:9)組成之群。
  15. 如請求項1、2及10至12中任一項之化合物或其醫藥學上可接受之鹽，其中X17 及X31 各自為KZ1 。
  16. 如請求項1、2及10至12中任一項之化合物或其醫藥學上可接受之鹽，其中X17 及X24 各自為KZ1 。
  17. 如請求項1、2及10至12中任一項之化合物或其醫藥學上可接受之鹽，其中X17 及X21 各自為KZ1 。
  18. 如請求項1、2及10至12中任一項之化合物或其醫藥學上可接受之鹽，其中X17 及X28 各自為KZ1 。
  19. 如請求項1、2及10至12中任一項之化合物或其醫藥學上可接受之鹽，其中X21 及X28 各自為KZ1 。
  20. 如請求項1、2及10至12中任一項之化合物或其醫藥學上可接受之鹽，其中X24 及X28 各自為KZ1 。
  21. 如請求項1、2及10至12中任一項之化合物或其醫藥學上可接受之鹽，其中X17 及X40 各自為KZ1 。
  22. 如請求項1、2及10至12中任一項之化合物或其醫藥學上可接受之鹽，其中X21 及X40 各自為KZ1 。
  23. 如請求項1之化合物或其醫藥學上可接受之鹽，其中該化合物選自由以下組成之群： Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )12 -CO2 H)SSGAPPPS-NH2 ； Y-Aib-EGT-aMeF(2F)-TSD-4Pal-SI-aMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))AQ-Aib-EFI-(D-Glu)-aMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(10-(4-羧基苯氧基)癸醯基))SSGAPPPS-NH2 ； Y-Aib-EGT-aMeF(2F)-TSD-4Pal-SI-aMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(4-(4-碘苯基)丁醯基))AQ-Aib-EFI-(D-Glu)-aMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(4-(4-碘苯基)丁醯基))SSGAPPPS-NH2 ； Y-Aib-EGT-aMeF(2F)-TSD-4Pal-SI-aMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(4-(4-三級-丁基苯基)丁醯基))AQ-Aib-EFI-(D-Glu)-aMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-(4-(4-三級-丁基苯基)丁醯基))SSGAPPPS-NH2 ；及 Y-Aib-EGT-αMeF(2F)-TSD-4Pal-SI-αMeL-LD-Orn-K((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )AQ-Aib-EFI-(D-Glu)-αMeY-LIEGGK((2-[2-(2-胺基-乙氧基)-乙氧基]-乙醯基)2 -(γ-Glu)-CO-(CH2 )10 -CH3 )SSGAPPPS-NH2 。
  24. 一種如請求項1至23中任一項之化合物或其醫藥學上可接受之鹽的用途，其用於製造用於治療選自由以下組成之群之病況的藥劑：2型糖尿病、肥胖症、NAFLD、非酒精性脂肝炎、血脂異常及代謝症候群。
  25. 一種如請求項1至23中任一項之化合物或其醫藥學上可接受之鹽的用途，其用於製造用於治療肥胖症之藥劑。
  26. 一種如請求項1至23中任一項之化合物或其醫藥學上可接受之鹽的用途，其用於製造用於治療2型糖尿病之藥劑。
  27. 一種醫藥組合物，其包含如請求項1至23中任一項之化合物或其醫藥學上可接受之鹽，及至少一種醫藥學上可接受之載劑、稀釋劑或賦形劑。
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