KR20220129802A - herb extract improving kidney function and herb pill - Google Patents
herb extract improving kidney function and herb pill Download PDFInfo
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Abstract
Description
본 발명은 신장기능 개선용 한방 추출액 및 한방 환에 관한 것으로서, 보다 상세하게는 호지자, 산귀래, 위령선, 삼엽초, 쇠비듬, 황매목, 함초를 이용한 새로운 조성의 신장기능 개선용 한방 추출액 및 한방 환에 관한 것이다.The present invention relates to oriental herbal extracts and oriental medicine pills for improving renal function, and more particularly, herbal extracts and herbal medicines for improving renal function of a new composition using hojija, sanguirae, wiryungseon, samyeopcho, dandruff, hwangmaemok, green tea. It's about the ring.
신장은 체내 대사산물 및 노폐물을 걸러서 소변으로 배출하는 주 기능 이외에 체내 수분량과 전해질, 산성도 등을 좁은 범위 안에서 일정하게 유지하는 생체 항상성 유지 기능, 그리고 혈압 유지, 빈혈 교정 및 칼슘과 인 대사에 중요한 여러 가지 호르몬을 생산하고 활성화시키는 내분비 기능 등을 갖는 기관이다. In addition to the main function of filtering body metabolites and waste products and excreting them in urine, the kidney functions to maintain body homeostasis by maintaining a constant amount of water, electrolytes, and acidity within a narrow range, as well as various important functions for maintaining blood pressure, correcting anemia, and calcium and phosphorus metabolism. It is an organ with endocrine functions that produce and activate branch hormones.
한편, 현대의학의 발전에도 불구하고 많은 사람들이 신장질환을 앓고 있는데, 기존의 약물 치료의 경우에 약물에 의한 위장 손상 등의 문제점들이 지적되고 있다.On the other hand, despite the development of modern medicine, many people suffer from kidney disease. In the case of conventional drug treatment, problems such as gastrointestinal damage caused by drugs are pointed out.
본 발명은 상기와 같은 문제점에 착안하여 제안된 것으로서, 본 발명의 목적은 호지자, 산귀래, 위령선, 삼엽초, 쇠비듬, 황매목, 함초를 이용하여 신장기능의 개선효과를 얻을 수 있는 새로운 조성의 한방 추출액 및 한방 환을 제공하는 것이다.The present invention has been proposed in view of the above problems, and an object of the present invention is to obtain a new composition that can improve kidney function using hojija, sanguirae, wiryongseon, samyeopcho, dandruff, hwangmaemok, and green tea. to provide herbal extracts and herbal pills of
본 발명의 특징에 따르면, 호지자, 산귀래, 위령선, 삼엽초, 쇠비름, 황매목, 함초를 동일 중량으로 물에 넣고 가열하여 유효성분을 열수추출한 것으로 이루어진 것을 특징으로 하는 신장기능 개선용 한방 추출액이 제공된다.According to the characteristics of the present invention, an oriental herbal extract for improving kidney function, characterized in that it consists of hot water extraction of active ingredients by heating hojija, sanguirae, wiryongseon, samyeopcho, purslane, hwangmaemok, and green tea with the same weight in water. provided
본 발명의 또 다른 특징에 따르면, 호지자 분말, 산귀래 분말, 위령선 분말, 삼엽초 분말, 쇠비름 분말, 황매목 분말, 함초 분말이 동일 중량으로 혼합된 약재혼합분말을 제환하여 제조된 것을 특징으로 하는 신장기능 개선용 한방 환이 제공된다.According to another feature of the present invention, it is characterized in that it is manufactured by refilling a medicinal herb mixture powder in which Hojija powder, Sanguirae powder, Wiryungseon powder, Trifolium ginseng powder, purslane powder, Hwangmae-mok powder, and green tea powder are mixed in equal weights. An oriental medicine pill for improving kidney function is provided.
본 발명의 또 다른 특징에 따르면, 상기 한방 환은 상기 약재혼합분말을 호지자, 산귀래, 위령선, 삼엽초, 쇠비름, 황매목, 함초를 동일 중량으로 물에 넣고 가열하여 얻은 열수추출액으로 반죽하여 제환된다. According to another feature of the present invention, the oriental medicine pill is made by kneading the medicinal herb mixture powder with hot water extract obtained by heating hojija, sanguirae, wiryongseon, samyeopcho, purslane, hwangmaemok, and green tea in the same weight in water. .
이상과 같은 구성의 본 발명은 호지자, 산귀래, 위령선, 삼엽초, 쇠비듬, 황매목, 함초를 물로 다려서 이들 약재들의 유효성분들을 추출한 것으로서, 신장기능 개선에 좋은 효과를 가진다.The present invention of the configuration as described above extracts the active ingredients of these medicinal substances by ironing hojija, sanguirae, wiryongseon, samyeopcho, dandruff, hwangmaemok, and green tea with water, and has a good effect on improving renal function.
또한, 본 발명은 상기 재료들을 분말화하여 환으로 만들 수도 있는데, 환으로 만들면 휴대 및 복용이 용이한 장점을 가진다. In addition, the present invention can be made into a pill by pulverizing the above materials, and when made into a pill, it has the advantage of being easy to carry and take.
이하에서는 본 발명을 각 실시예에 따라 좀 더 구체적으로 설명한다.Hereinafter, the present invention will be described in more detail according to each embodiment.
본 발명의 제1실시예에 따른 제조과정을 살펴보면 다음과 같다.The manufacturing process according to the first embodiment of the present invention will be described as follows.
1) 호지자, 산귀래, 위령선, 삼엽초, 쇠비듬, 황매목, 함초를 준비한다. 1) Prepare hojija, sanguirae, wiryyeongseon, samyeopcho, dandruff, hwangmaemok, and green tea.
준비한 약재들은 깨끗하게 세척하고 적당한 크기로 절단한다. Prepared medicinal materials are cleaned and cut into appropriate sizes.
상기 각각의 약재들에 대해 살펴보면 다음과 같다. Looking at each of the above medicines are as follows.
- 호지자(胡枝子)는 콩과에 속하는 다년생 낙엽관목인 싸리나무(Lespedeza bicolor)의 줄기와 잎이다. 맛은 달고 성질은 평(平)한데, 윤폐(潤肺), 청열(淸熱), 이수(利水), 임통(淋通)의 효능이 있으며, 백일해(百日咳), 비출혈(鼻出血), 임병(淋病)을 치료하는 효과가 있는 것으로 알려져 있다. - Hojija (胡枝子) is the stem and leaves of Lespedeza bicolor, a perennial deciduous shrub belonging to the legume family. The taste is sweet and the nature is flat, and it has the effects of circulation and fever, irritability, and pain. It is known to be effective in treating morbidity (淋病).
- 산귀래(山歸來)는 한방에서는 토복령(土茯岺)이라 하는데, 백합과에 속하는 덩굴성 관목으로 청미래덩굴 또는 망개나무의 뿌리이다. 산귀래는 해열, 해독, 이뇨 등의 증상완화, 체력증강 및 피부염, 신장염, 방광염, 항균작용, 관절염, 유방암 등에 효과가 있는 것으로 알려져 있다. - Sanguirae (山歸來) is called Tobokryeong (土茯岺) in oriental medicine. It is a creeping shrub belonging to the family Liliaceae, and is the root of the blueberry vine. Sanguirae is known to be effective in relieving symptoms such as fever, detoxification, and diuresis, enhancing physical strength, dermatitis, nephritis, cystitis, antibacterial action, arthritis, and breast cancer.
- 위령선(Clematis manshurica)은 미나리아제비과(Ranumculaceae)에 속하는 으아리 및 동속식물의 뿌리를 칭하는 것으로, 그 성분으로는 아네모닌(anemonin), 아네모놀(anemonol), 스테롤(sterol), 사포닌(saponin) 등의 성분을 함유한 것으로 알려져 있으며, 해열 및 진통작용 등의 약리작용이 있다고 알려져 있다.- Clematis manshurica is the name of the root of the plant belonging to the family Ranumculaceae, and its components include anemonin, anemonol, sterol, and saponin. It is known to contain ingredients such as, and is known to have pharmacological effects such as antipyretic and analgesic effects.
- 삼엽초(三葉草)는 콩과에 딸린 여러해살이 풀로서, 야관문(夜關門)이라고도 불리운다. 삼엽초는 기침, 천식, 양기부족 등의 치료에 효과가 있는 것으로 알려져 있다. - Samyeopcho (三葉草) is a perennial herb belonging to the legume family, also called Yagwanmun (夜關門). Trifolium herb is known to be effective in the treatment of cough, asthma, and lack of yang.
- 쇠비름은 우리나라 전국 각지의 산기슭 밭이나 길가 빈터 등에 흔히 자라는 한해살이 풀로서, 오행초(五行草), 장명채(長命采), 마치채(馬齒菜) 등으로 불리기도 한다. 한방에서는 쇠비름을 해독, 창종, 편도선염, 이뇨 등의 약재로 사용하는데, 항산화 효과나 항암(dopamine의 역할), 심장병 (K+ 이온의 작용), 항염증(오메가-3-지방산의 역할), 당뇨(오메가-3-지방산에 의한 혈당조절) 등에도 효과가 좋은 것으로 알려져 있다.- Purslane is an annual grass that is commonly grown in fields at the foot of mountains or on roadside glades in Korea. In oriental medicine, purslane is used as medicine for detoxification, ulcer, tonsillitis, and diuresis. It is also known to be effective in blood sugar control by omega-3-fatty acids).
- 황매목(생강나무; Lindera obtusiloba Blume)은 녹나무과 식물인 생강나무 Benzoin obtusilobum O. Kuntz.의 가지를 말린 것이다. 황매목은 주요 유효성분으로 게라닐 아세테이트, 린더릭산, tsudzuic acid, L-펠란드린 등을 함유하며 이들 성분이 간 보호,와 항당뇨 그리고 항산화활성을 갖는 것으로 알려져 있다. - Hwangbaek (Ginger; Lindera obtusiloba Blume) is the dried branch of Benzoin obtusilobum O. Kuntz., a plant belonging to the camphor family. Hwangmae-mok contains geranyl acetate, linderic acid, tsudzuic acid, and L-pelandrin as main active ingredients, and these ingredients are known to have liver protection, antidiabetic and antioxidant activity.
- 함초(Salicornia spp.)는 명아주 과의 한해살이 풀로 국내 자생하는 대표적인 식용 및 약용 염생식물이다. 함초는 오랫동안 민간약으로 시력저하, 소화불량, 위장병, 간염, 신장병 등에 사용되어 왔고, 항산화, 항당뇨, 항암, 항고혈압, 항고지혈증, 피부미백 효과가 있는 것으로 알려져 있다. - Green tea (Salicornia spp.) is a representative edible and medicinal halophyte that grows wild in Korea. Green tea has long been used as a folk medicine for vision loss, indigestion, gastrointestinal disease, hepatitis, kidney disease, etc.
2) 상기 약재들의 유효성분을 열수추출한다.2) Extract the active ingredients of the above medicines with hot water.
전기 약탕기에 상기 약재들을 동일 중량으로 넣고, 약재들 중량의 10~12배 정도의 물을 붓고 약재들의 유효성분들을 열수추출한다. 약재들의 유효성분들이 충분히 용출되도록 100~120℃, 1.5~2기압으로 하여 4~8시간 정도 가열처리한다.Put the medicines in the same weight in the electric medicine pot, pour water 10 to 12 times the weight of the medicines, and extract the active ingredients of the medicines with hot water. Heat treatment for 4 to 8 hours at 100~120℃ and 1.5~2 atm so that the active ingredients of the drugs are sufficiently eluted.
3) 상기 과정에서 달인 것에서 액상분만 여과하여 분리수득하여 한방 추출액을 수득한다. 3) In the above process, only the liquid from the decoction is filtered to obtain a separation to obtain an oriental medicine extract.
이와 같이 수득된 한방 추출액은 크레아티닌농도, 혈중 요소질소 농도, 부종지수를 저하시키는 등 신장기능개선 효과를 가진다. 이러한 본 발명은 100∼130ml 정도씩 하루에 3번, 최소 30일 정도 복용하면 유효한 효과를 얻을 수 있으며, 장기 복용하면 그 효과가 향상된다. 특히, 본 발명은 약용식물을 이용한 것이므로 장기간 복용하여도 위장장애가 발생될 우려가 없다. The herbal extract thus obtained has the effect of improving renal function, such as lowering creatinine concentration, blood urea nitrogen concentration, and edema index. The present invention can obtain an effective effect when taken about 100-130ml 3 times a day for at least 30 days, and the effect is improved when taken for a long time. In particular, since the present invention uses medicinal plants, there is no risk of gastrointestinal disorders even when taken for a long period of time.
실험예 1Experimental Example 1
전기 약탕기에 호지자, 산귀래, 위령선, 삼엽초, 쇠비듬, 황매목, 함초를 각각 200g 씩을 넣고, 물 1400L를 추가하여 100~110℃, 1.5~2기압으로 하여 5시간 가열한 다음, 여과하여 액상분만 분리하여 한방 추출액을 수득하였다.Put 200g each of hojija, sanguirae, wiryongseon, samyeopcho, dandruff, hwangmaemok, and green tea in an electric pot, add 1400L of water, heat at 100~110℃ and 1.5~2 atm for 5 hours, then filter and filter. The liquid fraction was separated to obtain an herbal extract.
수득한 한방 조성물을 신장염진단을 받은 남녀환자 50명에서 1달 동안 110ml씩 3번 복용하게 한 다음, 신장 기능 측정지표인 크레아티닌 농도, 혈중 요소질소 및 부종 지수를 측정하였다.The obtained oriental herbal composition was administered to 50 male and female patients diagnosed with nephritis three times for one month at 110 ml each, and then, the renal function measurement index, creatinine concentration, blood urea nitrogen, and edema index were measured.
- 크레아티닌 농도- Creatinine concentration
: 체험 임상자들의 크레아티닌 농도는 본 발명의 섭취 전에는 1.43mg/dl이였으나, 본 발명 섭취 후에는 1.30mg/dl로 감소되었다. 혈중 크레아티닌 농도의 정상범위는 0.5~1.4mg/dl이다. : The creatinine concentration of experienced clinicians was 1.43 mg/dl before ingestion of the present invention, but decreased to 1.30 mg/dl after ingestion of the present invention. The normal range for serum creatinine concentration is 0.5 to 1.4 mg/dl.
- 혈중 요소질소 농도- Blood urea nitrogen concentration
: 체험 임상자들의 혈중 요소질소 농도는 본 발명 섭취 전에는 23.21mg/dl이였으나, 본 발명 섭취 후에는 19.40mg/dl이였다. 혈중 요소질소의 정상범위는 6~20mg/dL이다. : The blood urea nitrogen concentration of experienced clinicians was 23.21 mg/dl before intake of the present invention, but was 19.40 mg/dl after intake of the present invention. The normal range of blood urea nitrogen is 6-20 mg/dL.
- 부종지수 - Edema index
: 체험 임상자들의 부종 지수를 생체 전기 임피던스 분석법으로 측정한 결과, 본 발명 섭취 전에는 전신 수분비율이 0.40mg/dl이였으나, 섭취 후에는 0.376mg/dl로 전신 수분비율이 떨어져 부종지수가 감소됨을 확인할 수 있었다. : As a result of measuring the edema index of experienced clinicians by bioelectrical impedance analysis, the systemic water ratio was 0.40 mg/dl before ingestion of the present invention, but after ingestion, the whole body water ratio dropped to 0.376 mg/dl, indicating that the edema index was reduced. could check
이하에서는 본 발명의 다른 실시예를 설명하되 전술한 실시예와 동일한 구성 및 효과에 대해서는 설명을 생략한다.Hereinafter, other embodiments of the present invention will be described, but descriptions of the same configurations and effects as those of the above-described embodiments will be omitted.
본 발명의 제2실시예에서는 상기 약재들을 사용하여 한방 환을 만드는데, 그 제조과정을 살펴보면 다음과 같다. In the second embodiment of the present invention, herbal pills are made using the above medicinal materials, and the manufacturing process thereof is as follows.
1) 비수리, 산귀래, 위령선, 삼엽초, 쇠비듬, 황매목, 함초를 준비하고, 깨끗하게 세척한 다음, 물기를 제거한다.1) Prepare bisuri, sanguirae, wiryongseon, samyeopcho, dandruff, hwangmae-mok, and green tea, wash thoroughly, and remove moisture.
2) 세척한 약재들을 동일한 중량으로 계량하여 분쇄기로 분쇄하여 약재혼합분말을 만든다. 2) Measure the washed medicines in the same weight and grind them with a grinder to make a medicine mixture powder.
3) 상기 과정에서 만든 약재혼합분말을 반죽하여 제환한다.3) Knead the medicine mixture powder made in the above process and make a pill.
약재혼합분말을 물이나 꿀로 반죽하여 제환기로 제환하는데, 바람직하게는 전술한 실시예에서 설명한 것과 같은 한방 추출액을 이용하여 약재혼합분말을 반죽한다. The herbal medicine powder is kneaded with water or honey and then circulated with a ventilator. Preferably, the medicinal medicine mixture powder is kneaded using the same oriental herbal extract as described in the above-described embodiment.
이와 같이 한방 추출액을 이용하여 제환을 하면 제조된 한방 환에 상기 약재들의 유효성분 함량이 증가되어 한층 더 유효한 신장기능 개선효과를 기대할 수 있을 것이다.In this way, when the pill is made using the herbal extract, the content of the active ingredient of the above medicines is increased in the manufactured oriental pill, so that a more effective improvement in renal function can be expected.
실험예 2Experimental Example 2
호지자, 산귀래, 위령선, 삼엽초, 쇠비듬, 황매목, 함초를 각각 200g을 분쇄기에 넣고 분쇄하여 약재혼합분말을 만들었다. 전술한 실험예 1과 같은 방법으로 만든 한방 추출액으로 상기 약재혼합분말을 반죽하고, 제환기로 제환하여 한방 환을 만든다. 200g each of hojija, sanguirae, wiryongseon, samyeopcho, dandruff, hwangmaemok, and green tea was put in a grinder and pulverized to make a medicinal herb mixture powder. The herbal medicine mixture powder was kneaded with the herbal extract prepared in the same manner as in Experimental Example 1 above, and the mixture was recirculated with a ventilation machine to make an oriental medicine pill.
이와 같이 만든 한방 환을 신부전증 진단을 받은 남녀환자 30명에서 1달 동안 한번에 10알 씩 하루에 3번 복용하게 한 다음, 신장 기능 측정지표인 크레아티닌 농도, 혈중 요소질소 및 부종 지수를 측정하였다.Thirty male and female patients diagnosed with renal insufficiency were given 10 pills 3 times a day for 1 month, and then, the creatinine concentration, blood urea nitrogen and edema index, which are indicators of renal function, were measured.
- 크레아티닌 농도- Creatinine concentration
: 체험 임상자들의 크레아티닌 농도는 본 발명 섭취 전에는 2.43mg/dl이였으나, 본 발명 섭취 후에는 1.50mg/dl로 감소되었다. : The creatinine concentration of experienced clinicians was 2.43 mg/dl before intake of the present invention, but decreased to 1.50 mg/dl after intake of the present invention.
- 혈중 요소질소 농도- Blood urea nitrogen concentration
: 체험 임상자들의 혈중 요소질소 농도는 본 발명 섭취 전에는 52.32mg/dl이였으나, 본 발명 섭취 후에는 45.20mg/dl이였다. : The blood urea nitrogen concentration of experienced clinicians was 52.32 mg/dl before intake of the present invention, but was 45.20 mg/dl after intake of the present invention.
- 부종지수 - Edema index
: 체험 임상자들의 부종 지수를 생체 전기 임피던스 분석법으로 측정한 결과, 본 발명 섭취 전에는 전신 수분비율이 0.54mg/dl이였으나, 본 발명 섭취 후에는 0.43mg/dl이였다. : As a result of measuring the edema index of experienced clinicians by bioelectrical impedance analysis, the body water ratio was 0.54 mg/dl before intake of the present invention, but was 0.43 mg/dl after intake of the present invention.
Claims (3)
An oriental herbal extract for improving kidney function, characterized in that it consists of hot water extraction of active ingredients by heating hojija, sanguirae, wiryongseon, samyeopcho, purslane, hwangmae-mok, and green tea in the same weight in water.
An oriental medicine pill for improving renal function, characterized in that it is prepared by mixing medicinal herbs powder mixed with hojija powder, sanguirae powder, wiryungseon powder, trilobite powder, purslane powder, hwangmaemok powder, and green tea powder in the same weight.
상기 한방 환은 상기 약재혼합분말을 동일 중량의 호지자, 산귀래, 위령선, 삼엽초, 쇠비름, 황매목, 함초를 물에 넣고 가열하여 유효성분을 열수추출한 한방 추출액으로 반죽하여 제환된 것을 특징으로 하는 신장기능 개선용 한방 환.3. The method of claim 2,
The oriental medicine pill is made by kneading the herbal medicine mixture powder with the same weight of hojija, sanguirae, wiryongseon, samyeopcho, purslane, hwangmaemok, and green tea in water and heating it to knead the active ingredient with hot water extract. Oriental medicine pills for functional improvement.
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| KR101106042B1 (en) | 2009-04-20 | 2012-01-18 | 김세희 | Composition containing sulfur for improvement of kidney function |
| KR101735057B1 (en) | 2015-06-23 | 2017-05-12 | 경상대학교산학협력단 | Composition for preventing or treating liver and kidney disorder comprising osmotin protein or osmotin peptide as effective component |
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| KR101106042B1 (en) | 2009-04-20 | 2012-01-18 | 김세희 | Composition containing sulfur for improvement of kidney function |
| KR101735057B1 (en) | 2015-06-23 | 2017-05-12 | 경상대학교산학협력단 | Composition for preventing or treating liver and kidney disorder comprising osmotin protein or osmotin peptide as effective component |
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