KR20220080874A - Oral composition - Google Patents

Abstract

The present invention provides a combination of Garcinia Cambogia extract, more preferably Garcinia Cambogia extract and Carbazochrome or a pharmaceutically acceptable salt thereof, as an active ingredient. Prevention, improvement or improvement of oral diseases or It relates to a composition for treatment, and more particularly, to a composition having a preventive, ameliorating, or therapeutic effect on shirin. The compositions of the present invention have few side effects and are safe to the human body and have excellent effects, and can be used as oral hygiene compositions, pharmaceutical compositions, quasi-drugs compositions, or food compositions.

Description

Oral composition {ORAL COMPOSITION}

The present invention relates to a composition for oral care for oral care, and to a composition that has few side effects and is safe to the human body and is effective in preventing, improving or treating gum disease or oral disease.

Oral disease is known as a major factor causing various clinical symptoms such as pain, masticatory dysfunction, destruction of periodontal tissue, bad breath and sore throat, and is a major factor in causing tooth loss. is currently doing.

On the other hand, a symptom called toothache or tooth hypersensitivity refers to a symptom of toothache when eating sour fruit or drinking cold beverages. When it regresses, the dentinal tubules that were protected by the gums are exposed. In order to improve these symptoms, toothpaste for the prevention of sore throat is being developed, and treatment is performed to fill the exposed dentinal tubules with resin, etc. at the dentist. However, in the case of a toothpaste that uses the conventional sealing effect of dentinal tubules, it contains a fine powder of the active ingredient to seal the dentinal tubules. These powders are usually diluted quickly in the process of brushing, and in the process of rinsing with water. There was a problem in that the customs were not sealed and exposed again because most of them were washed away.

Recently, development of oral products using plant extracts has been attempted, but there is still a problem that the effect is insignificant.

Therefore, there is a need to develop an oral product that is safe and has significantly superior efficacy for oral health using plant-derived natural materials such as plant extracts without any concerns about the above problems.

An object of the present invention is to provide a new active ingredient that is safe for the human body and for oral health, that is, a useful use of such an active ingredient, and an oral composition comprising an active ingredient having excellent efficacy as an active ingredient.

In addition, the present invention is to provide an oral care composition, a pharmaceutical composition, a quasi-drug composition, or a food composition using such a composition.

In order to solve the above problems, the present invention provides a composition for oral use containing a natural substance-derived, that is, Garcinia cambogia extract as an active ingredient. In addition, the present invention provides a composition for oral use comprising (a) Garcinia cambogia extract and (b) Carbazochrome or a pharmaceutically acceptable salt thereof as active ingredients.

More specifically, the present invention provides a combination of Garcinia cambogia extract, more preferably (a) Garcinia cambogia extract and (b) Carbazochrome or a pharmaceutically acceptable salt thereof for gum protection or oral cavity Provided is a use for preventing, ameliorating or treating a disease.

Researchers of the present invention conducted a study for the development of a composition for oral use that is harmless to the human body and can exhibit effects such as gum protection or treatment, prevention, and improvement of various oral diseases. As a result, it was confirmed that the composition containing the extract of Garcinia cambogia can have an effect of preventing, ameliorating, or treating symptoms of a particularly excellent sirin along with an excellent antibacterial effect, and thus the present invention has been completed. Furthermore, it was confirmed that the composition containing Garcinia cambogia extract and carbazochrome together can have an exceptionally excellent effect by synergistically increasing the prevention, improvement and treatment effects of gum protection and various oral diseases, and complete the present invention. became

As used herein, the term " Garcinia Cambogia " is a plant belonging to the family Clusiaceae of the order Malpighiales, which inhabits India or Indonesia. Currently, it is known as a diet supplement and the like in relation to its effect on weight loss.

In the present invention, the Garcinia cambogia extract can be extracted from various organs (eg, leaves, roots, stems, branches, fruits, fruit skins, seeds, etc.) of Garcinia cambogia.

As used herein, the term "extract" is an extract obtained by extraction of Garcinia cambogia, a diluted or concentrated liquid of the extract, a dried product obtained by drying the extract, a prepared or purified product of the extract, or a mixture thereof, etc., It refers to the extract of all formulations that can be formed using the extract itself and the extract.

In one aspect of the present invention, the type of extraction solvent used for extracting the Garcinia cambogia is not particularly limited, and any solvent known in the art may be used. Non-limiting examples of the extraction solvent include water, distilled water, C1 to C4 lower alcohol, acetone, ether, benzene, chloroform, ethyl acetate, methylene chloride, n-hexane, hydrochloric acid, acetic acid, formic acid, diethyl ether, cyclo and any one or two or more solvents selected from the group consisting of hexane, dipropylene glycol, hexanediol, and 1,3-butylene glycol.

Preferably, in another aspect of the present invention, the Garcinia cambogia extract is extracted with distilled water, a C1 to C4 lower alcohol, or a mixed solvent thereof.

In the present invention, the extraction method for extracting the Garcinia cambogia extract is not particularly limited, and may be extracted according to a method commonly used in the art. The extraction method may be hot water extraction, immersion extraction, reflux cooling extraction, or ultrasonic extraction method, and these may be performed alone or in combination of two or more methods. Preferably, it may be extracted by hot water extraction or immersion extraction method.

In one aspect of the present invention, the Garcinia cambogia extract is included in an amount of 0.0001 to 30% by weight based on the total weight of the composition, preferably 0.001 to 20% by weight based on the total weight of the composition.

In one embodiment of the present invention, the carbazochrome (Carbazochrome) or a pharmaceutically acceptable salt thereof is, for example, carbazochrome, carbazochrome sulfonate, carbazochrome sodium sulfonate, carbazochrome salicylate , carbarochrome sulfonic acid, etc., but is not limited thereto, and may preferably be carbazochrome.

In one aspect of the present invention, the garcinia cambogia extract is included in 0.0001 to 30% by weight based on the total weight of the composition, and carvazochrome or a pharmaceutically acceptable salt thereof is included in 0.0001 to 20% by weight relative to the total weight of the composition, preferably Preferably, the Garcinia cambogia extract is included in an amount of 0.001 to 20% by weight based on the total weight of the composition, and carbazochrome or a pharmaceutically acceptable salt thereof is included in an amount of 0.001 to 10% by weight relative to the total weight of the composition.

In the present invention, the oral composition may be used in the form of an oral hygiene composition, a pharmaceutical composition, a quasi-drug composition, or a food composition, but is not necessarily limited to these forms.

In the present invention, the composition according to the present invention may be for preventing, improving or treating gum protection or oral disease.

In the present invention, the oral disease may include various diseases in the oral cavity that may be caused by external physical stimuli as well as the influence of microorganisms in the oral cavity, for example, the dentin tubule is exposed due to tooth surface abrasion, etc. Hypersensitivity reactions may also include symptoms.

In the present invention, the oral disease is, for example, but not limited to, sore throat, bad breath, dental caries, periodontal disease, gingivitis, periodontitis, pulpitis, oral mucositis, stomatitis, oral mucosal ulceration, thrush, lichen planus , and other oral inflammatory lesions.

In the present invention, "prevention" means any action that suppresses or delays a desired symptom by administering the composition of the present invention.

In the present invention, "improvement" refers to any action in which the desired symptom is improved or advantageously changed by administering the composition of the present invention than before administration.

In the present invention, "treatment" means any action that improves or eliminates a desired disease or medical symptom by administering the composition of the present invention, and may be used as a concept including improvement.

As used herein, the term "mouth" is intended to mean the entire mouth cavity, including the lips, gums (gingiva), hard and soft palate, uvula, tonsils, teeth, medial cheeks, tongue and papilla. .

As used herein, the term “shirin-i” is not limited thereto, but refers to any phenomenon in which sharp, temporary, or continuous pain appears in response to external stimuli, regardless of dental caries or other pathological causes. The external stimulus usually means a temperature stimulus, and usually complains of a symptom to a cold temperature stimulus, but pain may also appear in a hot temperature stimulus. In addition to such temperature stimulation, pain may also appear due to stimulation such as dry teeth, contact with external substances, or osmotic pressure through sweet or sour food. It may appear on the entire tooth, or it may appear limited to a specific area such as the maxilla or mandible, or the right or left side, and may be accompanied by dentine hyperesthesia, caries, or pulp inflammation.

In another aspect of the present invention, the extract of Garcinia cambogia of the present invention is preferably included in a composition for preventing, ameliorating or treating syringi symptoms.

As used herein, the term "halitosis" may mean a symptom of an unpleasant odor from the mouth, but is not limited thereto, but is typically caused by volatile sulfur compounds generated when microorganisms in the oral cavity decompose proteins. It can cause an unpleasant odor from the mouth.

As used herein, the term “dental caries” refers to a condition in which tooth enamel is damaged by acid, which is generated when sugar, starch, etc., is decomposed by bacteria living in the mouth to cause tooth decay. The caries may be caused by a variety of causes, for example, may be cited as a cause of plaque (plaque), a bacterial film formed on the tooth surface.

As used herein, the term "periodontal disease" is an oral disease including gingivitis and periodontitis depending on the severity, and is also known as a trench mouth. Periodontal disease causes severe gingivitis, can cause bleeding and pus from the gums, is painful, and often causes premature loss of teeth. Symptoms of periodontal disease include sore gums, poor breathing, unpleasant bad breath, fever, bleeding gums under light pressure, thrush the size of a crater between the teeth and gums, swollen lymph nodes around the head, neck or jaw, and gray on the gums. Membrane, red gums, swollen gums, and pain when eating or swallowing.

As used herein, the term "gingivitis" is defined as inflammation of the gums and is a disorder characterized by periodontal disease, comprising gums, tissues, dental sacs, and structures that keep teeth in place. Characterized by the destruction of the ligaments that make up it. Gingivitis is one of the first stages of serious periodontal disease. Symptoms of gingivitis include swollen gums, sore mouth, bright red or purple appearance on the gums, shiny gums, gums that are painless except when touched, and bleeding gums.

As used herein, the term "periodontitis" (periodontitis or Pyorrhea alveolaris) is an inflammation of the periodontal tissue, including the tissues supporting the teeth in the oral cavity. The part included in the periodontal tissue is the periodontal ligament or PDL consisting of the gingiva (gum tissue), the alveolar bone which is the sockets to which the teeth are attached, the cementum or outer layer of the root, and the connective tissue fibers that connect the gums and the cementum to the alveolar bone. The symptoms are described as progressive loss of the bone around the teeth that loosens the teeth, or loss of teeth if left unattended. Periodontitis is considered an advanced form of gum disease because it already involves bone loss in that area.

As used herein, the term "pulpitis" is an inflammation occurring in the pulp inside the tooth where a number of nerves and blood vessels are distributed, and the pulp tissue is invaded by thermal stimulation, chemical stimulation, bacterial stimulation, etc. to cause necrosis. say to fall As inflammatory factors are released in response to noxious stimuli, blood vessels expand and blood flow increases, and when tissue edema occurs as a result, pulp, unlike general tissues, exists in a limited space surrounded by hard dentin. The end result will be different for other organizations.

As used herein, the term "oral mucositis" is a clinical condition in the oral cavity characterized by a painful symptom complex and the presence of reduced epithelial thickness, intense erythema and ulceration, associated with the possible development of infection and bleeding. and, in some cases, stomatitis and oral mucosal ulcers.

As used herein, the term "stomatitis" basically refers to inflammation of the oral cavity, but more specifically, stomatitis is the mucous lining of the oral cavity, which may include the gums, tongue, cheeks, lips, and the floor or ceiling of the mouth. It is an inflammation of the mucous lining. Stomatitis is classified according to how a person acquired the disease. Contact stomatitis is an inflammation of the oral mucosa caused by contact with an allergen or irritant. Aphthous stomatitis (also known as ulcerative stomatitis or aphthous ulcer) has an unknown etiology. Like contact stomatitis, ulcerative stomatitis affects the oral mucosa. Aphthous ulcers are a type of oral ulcers and are expressed as painful open sores in the mouth or upper throat (including the uvula) caused by mucosal destruction.

As used herein, the term “mouth mucosal ulcer” is also called stomatitis, but is not limited thereto, but is not limited thereto, due to infection by bacteria, viruses, fungi, etc. in the oral cavity (tongue, gums, lips, inside the cheeks) etc.) may include diseases that cause inflammation.

As used herein, the term "oral thrush" is a disease in which the fungus Candida albicans grows rapidly and uncontrolled in the mouth. Bacteria known as flora control the growth of Candida albicans in a healthy body. Thrush is a creamy white paste that covers the tongue and can quickly spread to the roof of the mouth, gums, back of the throat, tonsils and inside the cheeks.

As used herein, the term "lichen planus" (Lichen planus) is defined as an oral disease that often affects the inflamed mouth. Lichen planus is often recognized as a rash that irritates oral tissues. Lichen planus also occurs as a skin disease in the skin, and is often specifically referred to as lichen planus of the skin to differentiate it from oral lichen planus.

As used herein, the term "other oral inflammatory lesions" refers to other forms of oral inflammation (mucositis, caused by viral, bacterial, fungal or protozoan infection) or caused by immune system abnormalities (immune deficiency, autoimmunity, or allergy). including, but not limited to, caused mouth ulcers. Also included are oral submucosal fibrosis, a chronic debilitating disease of the oral cavity characterized by inflammation, and progressive fibrosis of the submucosal tissue. Also included are glossitis, inflammation or infection of the tongue.

The present invention provides an oral hygiene composition for protecting gums or preventing or improving oral diseases, comprising an extract of Garcinia cambogia as an active ingredient. In addition, the present invention provides an oral hygiene composition for protecting gums or preventing or improving oral diseases, comprising an extract of Garcinia cambogia and carbazochrome or a pharmaceutically acceptable salt thereof as active ingredients.

The oral care composition of the present invention includes all types and formulations that can be used for oral hygiene. Non-limiting examples of the oral care composition include toothpaste, mouthwash, oral spray, oral ointment, oral patch, gum, and the like.

When the oral care composition of the present invention is a toothpaste, in addition to including Garcinia cambogia extract as an active ingredient, an abrasive, binder, moisturizer, foaming agent, sweetener, whitening agent or flavoring agent may be additionally included. The abrasive includes aluminum hydroxide, silicic anhydride, aluminum silicate, dicalcium phosphate dihydrate and anhydride, tricalcium phosphate, calcium carbonate, calcium pyrophosphate, insoluble sodium metaphosphate, magnesium triphosphate, magnesium carbonate, calcium sulfate, Polymethyl methacrylate and the like may be used alone or in combination.

When the oral care composition is a paste-like composition, the binder is garrageenin, various cellulose derivatives for thickening, xanthan gum, gums such as tragacanth gum, polyvinyl alcohol, sodium polyacrylate, polyacrylic acid / An organic binder such as a synthetic polymer derivative such as a maleic acid copolymer or a carboxyvinyl polymer and an inorganic binder such as silica or laponite may be used alone or in combination.

In addition, the oral care composition may further include sorbitol, glycerin, ethylene glycol, propylene glycol, polyether glycol, polypropylene glycol, and the like as a moisturizing agent during the preparation thereof.

In addition, the oral care composition may further include a flavoring agent or a sweetener. The sweetener may be sucrose, lactose, maltose, sorbitol, xylitol, sodium cyclamate, glycerin, sodium saccharin, stevioside, aspartame, and the like, and the flavoring agent is peppermint, menthol, anethol, eugenol, It may be limonene, citronenol, alphaterpineol, salicylmethyl, cineol, linalol, ethylinarol, vanillin, thymol, spearmint oil, sesame oil, rosemary oil, cinnamon oil, etc., and the sweetener or flavoring agent is alone may be used as or in combination.

In addition, the oral care composition of the present invention may contain a surfactant used as a foaming component or an additional effective component alone or in combination. The surfactant used as the foaming component may be any one selected from the group consisting of anionic surfactants, nonionic surfactants and cationic surfactants.

When the oral care composition of the present invention is a toothpaste, it may be prepared by a conventional toothpaste manufacturing method except for including Garcinia cambogia extract as an active ingredient. It can be prepared by mixing Garcinia cambogia extract with a solution and formulating it as a toothbrushing solution, and can prevent or treat oral diseases by washing the oral cavity 2 to 10 times a day.

In addition, when the oral care composition of the present invention is a toothpaste cream, it may further include a liquid including water and a moisturizing agent, a gelling agent or a water-insoluble brightener, a sweetener, a flavoring agent, and the like.

In addition, when the oral care composition of the present invention is a mouthwash (cleansing agent), it may further include a toothpaste carrier, more specifically, a non-toxic alcohol.

With respect to the oral care composition of the present invention, the following pharmaceutical composition, quasi-drug composition and food composition may be applied mutatis mutandis.

In addition, the present invention provides a pharmaceutical composition for the prevention, improvement or treatment of gum protection or oral disease comprising an extract of Garcinia cambogia as an active ingredient. In addition, the present invention provides a pharmaceutical composition for preventing, improving or treating gum protection or oral disease, comprising an extract of Garcinia cambogia and carbazochrome or a pharmaceutically acceptable salt thereof as active ingredients.

In one aspect of the present invention, the garcinia cambogia extract is included in the pharmaceutical composition of the present invention in an amount of 0.0001 to 30% by weight based on the total weight of the composition, preferably 0.001 to 20% by weight based on the total weight of the composition.

In another aspect of the present invention, the garcinia cambogia extract is included in 0.0001 to 30% by weight based on the total weight of the composition in the pharmaceutical composition of the present invention, and carbazochrome or a pharmaceutically acceptable salt thereof is 0.0001 to 20 based on the total weight of the composition. % by weight, preferably the Garcinia cambogia extract is included in 0.001 to 20% by weight relative to the total weight of the composition, and carbazochrome or a pharmaceutically acceptable salt thereof is included in 0.001 to 10% by weight relative to the total weight of the composition.

In one aspect of the present invention, the pharmaceutical composition according to the present invention is a sore throat, bad breath, dental caries, periodontal disease, gingivitis, periodontitis, pulpitis, oral mucositis, stomatitis, mucosal ulceration in the oral cavity, thrush, lichen planus and other oral inflammations. It can exert a preventive, ameliorating or therapeutic effect on any one or more diseases selected from the group consisting of lesions.

The pharmaceutical composition according to the present invention may be prepared according to a method conventionally prepared in the industry for preparing the same.

In the present invention, the pharmaceutical composition according to the present invention may include the Garcinia cambogia extract alone as an active ingredient, and additional ingredients, that is, pharmaceutically acceptable carriers, excipients, It may further include a diluent or an auxiliary ingredient.

In the present invention, the pharmaceutical composition according to the present invention may be used as a single preparation, or may be prepared and used as a combined preparation by additionally including a drug known to have an effect of preventing, improving, or treating gum protection or oral disease.

In addition to the active ingredients, the pharmaceutical composition includes nutrients, vitamins, electrolytes, flavoring agents, colorants, enhancers, pectic acid and its salts, alginic acid and its salts, organic acids, protective colloidal thickeners, pH adjusters, stabilizers, preservatives, glycerin , alcohol, a carbonation agent used in carbonated beverages, and the like may be additionally contained. In addition, the carrier, excipient or diluent may be lactose, dextrose, sucrose, sorbitol, mannitol, xylitol, erythritol, maltitol, starch, achicia gum, alginate, gelatin, calcium phosphate, calcium silicate, cellulose, methyl cellulose, microcrystalline From the group consisting of cellulose, polyvinyl pyrrolidone, water, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate and mineral oil, dextrin, calcium carbonate, propylene glycol, liquid paraffin, physiological saline It may be one or more selected, but the present invention is not limited thereto, and all conventional carriers, excipients or diluents may be used.

The pharmaceutically acceptable carrier, excipient or diluent is not limited as long as it does not impair the effects of the present invention, and includes, for example, a filler, an extender, a binder, a wetting agent, a disintegrant, a surfactant, a lubricant, a sweetener, a fragrance, an anti-aggregant, Flavors, emulsifiers, preservatives, etc. may be included, and both oral and parenteral can be used.

In the present invention, solid preparations for oral administration include tablets, pills, powders, granules, capsules, etc., and these solid preparations include at least one excipient in the Garcinia cambogia extract, for example, starch, calcium carbonate (calcium carbonate), sucrose or lactose, gelatin, etc. are mixed and prepared. In addition to simple excipients, lubricants such as magnesium stearate and talc are also used. Liquid formulations for oral use include suspensions, internal solutions, emulsions, and syrups. In addition to commonly used simple diluents such as water and liquid paraffin, various excipients such as wetting agents, sweeteners, fragrances, and preservatives may be included. have.

In the present invention, the form for parenteral administration may include toothpaste, mouthwash, topical administration agent (cream, ointment, dressing solution, spray, other coating agents, etc.). An example of the formulation of the topical administration agent may be one in which a pharmaceutical composition including an active ingredient, Garcinia cambogia extract, is impregnated into a carrier such as gauze made of natural or synthetic fibers.

In the case of a cream or ointment, it may be suitable for direct application to or around the area of gingivitis, periodontitis, or caries. In the case of the spray, it may be prepared by a conventional spray preparation method, except that it contains Garcinia cambogia extract as an active ingredient, and it is filled and packaged in a compression container or other spray container and sprayed frequently to the area of oral disease to treat oral diseases. can be prevented or treated. In the case of the dressing solution, it may be prepared by a conventional dressing solution manufacturing method except for including Garcinia cambogia extract as an active ingredient, and it is used for dressings in oral disease sites or other bacterial infection sites for oral infections. can be prevented or treated.

In addition, the dosage form of the pharmaceutical composition of the present invention may be in a preferred form depending on the method of use, and in particular, by adopting a method known in the art to provide rapid, sustained or delayed release of the active ingredient after administration to a mammal. can be formulated. Examples of specific formulations include warning agents, granules, lotions, liniments, limonades, powders, syrups, liquids, aerosols, extracts, elixirs, ointments, fluid extracts, emulsions, suspensions, pills, pills, tablets, capsules, creams, pills, soft or hard gelatin capsules, and the like, but are not limited to these formulations.

In the present invention, the pharmaceutical composition may be administered in a pharmaceutically effective amount. The "pharmaceutically effective amount" means an amount sufficient to prevent oral disease or treat a related disease according to the present invention with a reasonable benefit or risk ratio applicable to medical treatment. Effective dose levels depend on factors including subject type and severity, age, sex, drug activity, sensitivity to drug, time of administration, route and excretion rate, duration of treatment, concomitant drugs, and other factors well known in the medical arts. can be determined accordingly. As an example, the administration may be administered once a day, or divided into several administrations. The above dosage does not limit the scope of the present invention in any way.

In addition, the pharmaceutical composition of the present invention may further include a compound or plant extract having a known oral disease inhibiting activity in addition to the Garcinia cambogia extract, and the content may be differently determined according to the manufacturing method and purpose of use.

With respect to the pharmaceutical composition of the present invention, the oral care composition, the following quasi-drug composition and the following food composition may be applied mutatis mutandis.

In addition, the present invention provides a quasi-drug composition for preventing or improving gum protection or oral disease, comprising the extract of Garcinia cambogia as an active ingredient. In addition, the present invention provides a quasi-drug composition for protecting gums or preventing or improving oral diseases, comprising an extract of Garcinia cambogia and carbazochrome or a pharmaceutically acceptable salt thereof as active ingredients.

The quasi-drug composition according to the present invention may further include, if necessary, a carrier, excipient or diluent commonly used in a quasi-drug composition in addition to the above active ingredient within the range that does not impair the purpose of the present invention. The carrier, excipient or diluent is not limited as long as it does not impair the effects of the present invention, for example, a filler, an extender, a binder, a wetting agent, a disintegrant, a surfactant, a preservative, a flavoring agent, a dispersing agent, a viscosity adjusting agent, a pH adjusting agent, a lubricant, sweetening agents, preservatives, and the like.

With respect to the quasi-drug composition of the present invention, the contents of the oral care composition, the pharmaceutical composition, and the following food composition may be applied mutatis mutandis.

In another aspect of the present invention, the present invention provides a product that is an oral care product, pharmaceutical product, quasi-drug or food product comprising the composition according to the present invention.

In addition, the present invention provides a food composition for the prevention or improvement of gum protection or oral disease comprising Garcinia cambogia extract as an active ingredient. In addition, the present invention provides a food composition for preventing or improving gum protection or oral disease, comprising an extract of Garcinia cambogia and carbazochrome or a pharmaceutically acceptable salt thereof as active ingredients.

In one aspect of the present invention, the Garcinia cambogia extract in the food composition of the present invention is included in an amount of 0.0001 to 30% by weight, preferably 0.001 to 20% by weight, based on the total weight of the composition.

In another aspect of the present invention, the garcinia cambogia extract is included in 0.0001 to 30% by weight based on the total weight of the composition in the food composition of the present invention, and carvazochrome or a pharmaceutically acceptable salt thereof is 0.0001 to 20 based on the total weight of the composition. % by weight, preferably the Garcinia cambogia extract is included in 0.001 to 20% by weight relative to the total weight of the composition, and carbazochrome or a pharmaceutically acceptable salt thereof is included in 0.001 to 10% by weight relative to the total weight of the composition.

In one aspect of the present invention, the food composition according to the present invention is a sore throat, bad breath, dental caries, periodontal disease, gingivitis, periodontitis, pulpitis, oral mucositis, stomatitis, mucosal ulceration in the oral cavity, thrush, lichen planus and other oral inflammations. It can exert a preventive or ameliorating effect on any one or more diseases selected from the group consisting of lesions.

In one aspect of the present invention, the food composition according to the present invention is a sore throat, bad breath, dental caries, periodontal disease, gingivitis, periodontitis, pulpitis, oral mucositis, stomatitis, mucosal ulceration in the oral cavity, thrush, lichen planus and other oral inflammations. It can exert a preventive or ameliorating effect on any one or more diseases selected from the group consisting of lesions. Preferably, Shirin can exert an effect in preventing or ameliorating symptoms.

In the present invention, the food composition of the present invention may further include suitable carriers, excipients and diluents commonly used in the preparation thereof.

As used herein, the term "food" refers to a natural product or processed product containing one or more nutrients, and preferably means a state that can be eaten directly through a certain processing process, usually As a phosphorus meaning, it includes all of food, food additives, functional foods, beverages, beverage additives, functional beverages, and the like.

As used herein, the term "functional food" refers to a food group or food composition with added value added to the food to act and express the function of the food for a specific purpose using physical, biochemical, and bioengineering methods, etc. Control, disease prevention and recovery means a food designed and processed to sufficiently express the body control function with respect to the living body, preferably, the functional food of the present invention has a body control function related to gum protection or prevention or improvement of oral disease It refers to food that can be sufficiently expressed in the living body. The functional food may include a food supplementary additive that is pharmaceutically acceptable, and may further include an appropriate carrier, excipient and diluent commonly used in the manufacture of functional food.

As used herein, the term "drink" refers to a generic term for drinking to quench thirst or enjoy taste, and is intended to include functional beverages. The beverage is not particularly limited in other ingredients other than including the active ingredient as an essential ingredient in the indicated ratio, and may contain various flavoring agents or natural carbohydrates as additional ingredients like a conventional beverage.

In addition to the above, the composition of the present invention includes various nutrients, vitamins, minerals (electrolytes), flavoring agents such as synthetic and natural flavoring agents, coloring agents and enhancers (cheese, chocolate, etc.), pectic acid and salts thereof, alginic acid and salts thereof , organic acids, protective colloidal thickeners, pH adjusters, stabilizers, preservatives, glycerin, alcohols, carbonation agents used in carbonated beverages, and the like. These components may be used independently or in combination.

As used herein, the term "functional beverage" refers to a beverage group or beverage composition that has added added value to act and express the function of the beverage for a specific purpose using physical, biochemical, biological engineering methods, etc. It refers to beverages designed and processed to sufficiently express body control functions related to rhythm control, disease prevention and recovery, etc.

The functional beverage is not particularly limited in other ingredients except for containing the Garcinia cambogia extract of the present invention as an essential ingredient in the indicated ratio, and may contain various flavoring agents or natural carbohydrates as additional ingredients like a conventional beverage. .

With respect to the food composition of the present invention, the contents of the oral care composition, pharmaceutical composition and quasi-drug composition may be applied mutatis mutandis.

All ingredients described in the present invention, preferably, relevant laws and regulations, such as Korea, China, the United States, Europe, Japan, etc. (for example, the Food Standards Code (Korea), Food Additives Code (Korea), Health Functional Foods Code (Korea) Korea) and sanitary standards (China)), etc., do not exceed the maximum use value. That is, preferably, the composition according to the present invention contains the components according to the present invention within the content limit allowed by the relevant laws and regulations of each country.

The composition comprising the Garcinia cambogia extract of the present invention as an active ingredient has an effect of protecting gums or preventing, improving or treating oral diseases. In addition, the composition of the present invention uses a plant-derived natural material, has few side effects, and exhibits excellent effects while being safe for the human body. In particular, the composition exhibits an excellent effect in preventing, ameliorating or treating symptoms of shirin.

In addition, the composition comprising the extract of Garcinia cambogia of the present invention and carbazochrome or a pharmaceutically acceptable salt thereof as an active ingredient provides an effect of protecting gums or preventing, improving or treating oral diseases. By using a combination of these active ingredients, the above-described effects are synergistically increased, and thus, more excellent effects are obtained.

1 is an experimental result confirming the inhibitory effect on IL-6 of the composition of the present invention.
2 is an experimental result confirming the inhibitory effect on PGE2 of the composition of the present invention.
3 is an experimental result confirming the inhibitory effect of the composition of the present invention on MMP1 and MMP3.

Hereinafter, examples and the like will be described in detail to help the understanding of the present invention. However, the embodiments according to the present invention may be modified in various other forms, and the scope of the present invention should not be construed as being limited to the following examples. The embodiments of the present invention are provided to more completely explain the present invention to those of ordinary skill in the art.

manufacturing example. Preparation of Garcinia Cambogia Extract

Garcinia cambogia extract of the present invention was prepared in the following way. Garcinia cambogia extract was purchased and used from Jooyoung NS.

Experimental Example 1. Inflammatory reaction experiment

( Experimental method )

THP-1 (human monocytic cells) was spread in RPMI1640 medium supplemented with 10% FBS and PMA (ug/ml) at 2×10 ⁵ cells/well in one well of a 24-well plate, 37°C Incubated for 24 hours in 5% CO ₂ was differentiated into macrophages (macrophage).

Garcinia cambogia extract and/or carbazochrome was pre-treated for 1 hour, and then E. coli LPS (1ug/ml) was treated for 24 hours.

ELISA was performed by dilution of the supernatant.

(result)

IL-6 shown in FIG. 1 is a cytokine involved in the initial inflammatory response, and plays various roles in regulating immune responses, such as leukocyte transport and activation, differentiation and activation of T cells and B cells. As shown in FIG. 1 , it was confirmed that the Garcinia cambogia extract could relieve inflammation such as gingivitis or periodontitis by inhibiting cytokines involved in inflammation and pain response. In particular, when Garcinia cambogia extract and carbazochrome were used together, the effect of alleviating inflammation such as gingivitis and periodontitis by inhibiting cytokines involved in inflammation and pain response was more excellent.

PGE2 shown in FIG. 2 is prostaglandin E2 (PGE2), a pain and inflammation marker. As shown in FIG. 2 , it was confirmed that the Garcinia cambogia extract could relieve inflammation such as gingivitis or periodontitis by inhibiting cytokines involved in inflammation and pain response. In particular, when Garcinia cambogia extract and carbazochrome were used together, the effect of alleviating inflammation such as gingivitis and periodontitis by inhibiting cytokines involved in inflammation and pain response was more excellent.

That is, it was confirmed that the mixture of garcinia cambogia extract, garcinia cambogia extract, and carbazochrome suppressed the inflammatory reaction, thereby relieving the inflammation of gingivitis and periodontitis.

Experimental Example 2. MMP1, 3 inhibitory effect test

( Experimental method )

HGF-1 (human gingival fibroblast) was spread at 2×10 ⁵ cells/well in one well of a 6-well plate in DMEM medium supplemented with 10% FBS, at 37° C. with 5% CO ₂ 24 time incubation.

Garcinia cambogia extract and/or carbazochrome was pre-treated for 1 hour, and then E. coli LPS (1ug/ml) was treated for 24 hours.

Cell lysis, RNA prep., cDNA synthesis, and real-time PCR were performed to examine the expression of MMP1 and 3.

(result)

The MMPs shown in FIG. 3 (more specifically, MMP1 and MMP3) are enzymes capable of decomposing gum tissue including collagen with matrix metalloproteinases. As shown in Figure 3, it was confirmed that the Garcinia cambogia extract can alleviate the degradation of the gum tissue by suppressing the expression of MMPs by LPS. In particular, when Garcinia cambogia extract and carbazochrome were used together, the effect of suppressing the expression of MMPs by LPS to alleviate the decomposition of the gum tissue was more excellent.

sample (μg/ml) MMP1 MMP3 Expression (%) Standard Deviation Expression (%) Standard Deviation unprocessed 5 0.1 7 0.3 LPS 1 μg/ml - 100 2.2 100 4.7 Garcinia Cambogia Extract 10 84 3.6 77 2.9 Garcinia Cambogia Extract 20 67 2.8 52 3.6 Carvazochrome 10 89 3.7 80 1.5 Garcinia Cambogia Extract 5 + Carbazochrome 5 35 2.3 39 2.9 Garcinia Cambogia Extract 10 + Carbazochrome 10 21 2.4 25 3.4

Experimental Example 3. Gingivitis formation inhibitory effect test

( Experimental method )

A control group and an experimental group toothpaste containing garcinia cambogia extract and/or carbazochrome were prepared and clinical trials were conducted on patients with gingivitis.

Control: Common toothpaste using sodium carboxymethyl cellulose, sodium lauryl sulfate, glycerin, colloidal silicon dioxide, silica, sodium cocoyl ethionate, dodicin and a sweetener, fragrance, colorant, etc.

Experimental group 1: Control + Garcinia cambogia extract 0.01 wt %

Experimental group 2: Control + Carbazochrome 0.01 wt %

Experimental group 3: Control + Garcinia cambogia extract 0.005 wt % + Carbazochrome 0.005 wt %

Experimental subjects : For patients with gingivitis with even teeth and no missing teeth, precise oral examinations were conducted for 30 patients according to sex at 10-year intervals from 30 to 50 years of age by age, and 40 subjects were selected and then 10 subjects each. was divided.

Frequency of use: Use 3 times a day, 2 hours after meals and before going to bed.

Gingivitis index measurement : The initial gingivitis index was scored by scouring the teeth, and each toothpaste composition was used. After 1 week, 1 month, and 3 months, oral examination was conducted to examine the gingivitis index. A periodontal probe was inserted into the gingival sulcus, and the probe was combusted around each tooth without applying any force, and the bleeding state was measured after 30 seconds.

Table 2 below shows the gingivitis index criteria.

score Contents 0 points bleeding-free 1 point normal bleeding condition 2 points glandular bleeding condition 3 points Interdental area triangular bleeding condition 4 points total gingival bleeding

( Experimental results )

After 1 week, the level of inflammation in the control group was 1.52, and the inflammation worsened even after 3 months.

Experimental groups 1, 2, and 3 all had low levels of inflammation, and in particular, the garcinia cambogia extract and carbazochrome combination experimental group (experimental group 3) had the lowest level of inflammation even though it contained less each component than experimental groups 1 and 2.

The experimental results are shown in Table 3 (unit: points) below.

hour control Experimental group 1 Experimental group 2 Experimental group 3 0 weeks 1.04±0.04 1.05±0.02 1.04±0.03 1.06±0.02 1 week 1.52±0.01 1.11±0.03 1.12±0.02 1.07±0.05 1 month 2.50±0.03 1.17±0.07 1.19±0.05 1.10±0.02 3 months 2.83±0.09 1.18±0.08 1.21±0.02 1.13±0.01

Experimental Example 4. Shirini inhibitory effect test

( Experimental method )

Clinical trials were conducted by preparing toothpaste for the control group and the experimental group containing Garcinia cambogia extract and/or carbazochrome.

Control: Common toothpaste using sodium carboxymethyl cellulose, sodium lauryl sulfate, glycerin, colloidal silicon dioxide, silica, sodium cocoyl ethionate, dodicin and a sweetener, fragrance, colorant, etc.

Experimental group 1: Control + Garcinia cambogia extract 0.01 wt %

Experimental group 2: Control + Carbazochrome 0.01 wt %

Experimental group 3: Control + Garcinia cambogia extract 0.005 wt % + Carbazochrome 0.005 wt %

Experimental subjects : 40 volunteers who agreed to participate in this experiment for people with dentin hypersensitivity teeth, and a total of 80 teeth. The 40 volunteers were 20 males and 20 males aged 20 to 50 years of age.

Frequency of use : 2 hours after meals, 3 times a day, 2 weeks before going to bed.

의 차가운 물을 스포이트로 떨어뜨려 평점을 매겼다. 2주 후 다시 약 5

의 차가운 물을 스포이트로 떨어뜨려 평점을 매겼다. Measurement : After applying a temperature stimulus, the patient's response was measured. Before conducting the test, each volunteer's hypersensitive teeth were checked in advance, and about 5

of cold water was dropped with a dropper and graded. About 5 again after 2 weeks

of cold water was dropped with a dropper and graded.

For statistical processing, the stimulus scores before and 2 weeks after the experiment were tested using the paired student-t test.

Table 4 below shows the reaction rating criteria.

score Contents 0 points no discomfort. 1 point Slightly uncomfortable or sore 2 points very uncomfortable or sore 3 points sick.

(Experiment result)

Experimental groups 1, 2, and 3 all had an inhibitory effect on sirin, and in particular, the experimental group combining Garcinia cambogia extract and carbazochrome (experimental group 3) had a superior inhibitory effect on sirin even though it contained less each component than in experimental groups 1 and 2.

The experimental results regarding the degree of sirin inhibition are shown in Table 4 (unit: points) below.

hour control Experimental group 1 Experimental group 2 Experimental group 3 0 weeks 2.13±0.09 2.14±0.07 2.13±0.11 2.14±0.10 2 weeks 2.14±0.10 1.73±0.12 1.76±0.09 1.62±0.11 P-value p>0.05 *p<0.05 *p<0.05 *p<0.05

Experimental Example 5. Halitosis inhibitory effect test

( Experimental method )

Clinical trials were conducted by preparing toothpaste for the control group and the experimental group containing Garcinia cambogia extract and/or carbazochrome.

Control: Common toothpaste using sodium carboxymethyl cellulose, sodium lauryl sulfate, glycerin, colloidal silicon dioxide, silica, sodium cocoyl ethionate, dodicin and a sweetener, fragrance, colorant, etc.

Experimental group 1: Control + Garcinia cambogia extract 0.01 wt %

Experimental group 2: Control + Carbazochrome 0.01 wt %

Experimental group 3: Control + Garcinia cambogia extract 0.005 wt % + Carbazochrome 0.005 wt %

Experimental subjects : 50 men and women without dental caries were selected, and a cross-over test was performed on the subject beverage.

Halitosis inducer : Commercially available garlic powder was dispersed in water, allowed to stand for 24 hours, and then diluted. Halimeter readings were over 700 ppb.

Measurement : Gargle was gargled with 15ml of garlic powder diluted solution for 30 seconds, and the degree of bad breath was measured with a Hallimeter after 1 minute, and brushed teeth for 30 seconds to 1 minute using the toothpaste of the control group and the experimental group. After 1 minute, 5 minutes, and 30 minutes after brushing teeth, the degree of bad breath was measured with a Hallimeter.

( Experimental results )

As of 30 minutes of experiment, the effect of inhibiting bad breath in the experimental group was better than that of the control group, and in particular, the experimental group of the combination of Garcinia cambogia extract and carbazochrome (Experimental Group 3) had better halitosis inhibitory effect than Experimental Groups 1 and 2, even though they contained less each component. Table 6 below shows the rate of inhibition of bad breath.

hour control Experimental group 1 Experimental group 2 Experimental group 3 1 minute 57.6% 95.2% 82.7% 98.3% 5 minutes 46.9% 92.6% 78.1% 95.2% 30 minutes 39.2% 89.4% 70.3% 93.7%

Claims (9)

Garcinia Cambogia ( Garcinia Cambogia ) Oral hygiene composition for preventing or improving gum protection or oral disease, comprising an extract as an active ingredient. A pharmaceutical composition for preventing, improving or treating gum protection or oral disease, comprising Garcinia cambogia extract as an active ingredient. A quasi-drug composition for preventing or improving gum protection or oral disease, comprising Garcinia cambogia extract as an active ingredient. The method according to any one of claims 1 to 3, wherein the oral disease is a sore throat, halitosis, dental caries, periodontal disease, gingivitis, periodontitis, pulpitis, oral mucositis, stomatitis, mucosal ulceration in the oral cavity, thrush, lichen planus and Any one or more diseases selected from the group consisting of other oral inflammatory lesions, the composition. 5. The composition of claim 4, wherein the oral disease is syringi. Garcinia Cambogia Extract; and
An oral care composition for preventing or improving gum protection or oral disease, comprising carbazochrome or a pharmaceutically acceptable salt thereof as an active ingredient. Garcinia cambogia extract and carbazochrome or a pharmaceutical composition for preventing, improving or treating gum protection or oral disease, comprising as an active ingredient a pharmaceutically acceptable salt thereof. A quasi-drug composition for preventing or improving gum protection or oral disease, comprising an extract of Garcinia cambogia and carbazochrome or a pharmaceutically acceptable salt thereof as active ingredients. 9. The method according to any one of claims 6 to 8, wherein the oral disease is a sore throat, halitosis, dental caries, periodontal disease, gingivitis, periodontitis, pulpitis, oral mucositis, stomatitis, mucosal ulceration in the oral cavity, thrush, lichen planus and Any one or more diseases selected from the group consisting of other oral inflammatory lesions, the composition.

Images