KR20220078607A - 융합 단백질들을 이용한 tcr 재프로그래밍을 위한 조성물 및 방법들 - Google Patents

융합 단백질들을 이용한 tcr 재프로그래밍을 위한 조성물 및 방법들 Download PDF

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KR20220078607A
KR20220078607A KR1020227012166A KR20227012166A KR20220078607A KR 20220078607 A KR20220078607 A KR 20220078607A KR 1020227012166 A KR1020227012166 A KR 1020227012166A KR 20227012166 A KR20227012166 A KR 20227012166A KR 20220078607 A KR20220078607 A KR 20220078607A
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tcr
domain
nucleic acid
sequence
recombinant nucleic
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패트릭 배월
로버트 호프마이스터
다니엘 겟츠
다리오 구티에레즈
필리프 키에퍼-권
줄리 도나헤이
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티씨알2 테라퓨틱스 인크.
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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KR1020227012166A 2019-09-12 2020-09-11 융합 단백질들을 이용한 tcr 재프로그래밍을 위한 조성물 및 방법들 Withdrawn KR20220078607A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962899563P 2019-09-12 2019-09-12
US62/899,563 2019-09-12
US202062971682P 2020-02-07 2020-02-07
US62/971,682 2020-02-07
PCT/US2020/050503 WO2021050948A1 (en) 2019-09-12 2020-09-11 Compositions and methods for tcr reprogramming using fusion proteins

Publications (1)

Publication Number Publication Date
KR20220078607A true KR20220078607A (ko) 2022-06-10

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KR1020227012166A Withdrawn KR20220078607A (ko) 2019-09-12 2020-09-11 융합 단백질들을 이용한 tcr 재프로그래밍을 위한 조성물 및 방법들

Country Status (10)

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EP (1) EP4028033A4 (https=)
JP (1) JP2022548866A (https=)
KR (1) KR20220078607A (https=)
CN (1) CN114828862A (https=)
AU (1) AU2020344628A1 (https=)
BR (1) BR112022004458A2 (https=)
CA (1) CA3154287A1 (https=)
IL (1) IL291236A (https=)
MX (1) MX2022002984A (https=)
WO (1) WO2021050948A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20210104772A (ko) 2018-12-14 2021-08-25 블루버드 바이오, 인코포레이티드. 이량체화제로 조절된 면역수용체 복합체
AU2021347807A1 (en) * 2020-09-23 2023-05-04 Myeloid Therapeutics, Inc. Improved methods and compositions for expression of nucleic acids in cells
WO2023091420A2 (en) * 2021-11-16 2023-05-25 TCR2 Therapeutics Inc. Compositions and methods for t cell engineering
CN118871460A (zh) * 2022-01-07 2024-10-29 维硕公司 经工程化的PD-L1靶向γδT细胞受体
WO2024039576A2 (en) * 2022-08-19 2024-02-22 Memorial Sloan-Kettering Cancer Center T cell receptors targeting ras mutations and uses thereof
WO2025217063A1 (en) * 2024-04-08 2025-10-16 Baylor College Of Medicine Dual stimulatory receptors for immunotherapy

Family Cites Families (14)

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Publication number Priority date Publication date Assignee Title
IL86278A (en) * 1988-05-04 2003-06-24 Yeda Res & Dev Endowing cells with antibody specificity using chimeric t cell receptor
WO2011059836A2 (en) * 2009-10-29 2011-05-19 Trustees Of Dartmouth College T cell receptor-deficient t cell compositions
CN107858333B (zh) * 2011-10-28 2022-05-27 瑞泽恩制药公司 T细胞受体基因修饰小鼠
JP2017529841A (ja) * 2014-09-19 2017-10-12 リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． キメラ抗原受容体
MX2018004721A (es) * 2015-10-23 2018-07-06 Eureka Therapeutics Inc Construcciones quimericas anticuerpo/receptor de celulas t y usos de las mismas.
GB201604494D0 (en) * 2016-03-16 2016-04-27 Immatics Biotechnologies Gmbh Transfected T-Cells and T-Cell receptors for use in immunotherapy against cancers
WO2018067993A1 (en) * 2016-10-07 2018-04-12 TCR2 Therapeutics Inc. Compositions and methods for t-cell receptors reprogramming using fusion proteins
JP7291396B2 (ja) * 2016-11-22 2023-06-15 ティーシーアール２ セラピューティクス インク． 融合タンパク質を用いたｔｃｒの再プログラミングのための組成物及び方法
EP3548055A4 (en) * 2016-12-02 2020-08-19 University of Southern California SYNTHETIC IMMUNE RECEPTORS AND THEIR PROCESSES FOR USE
JP2020513754A (ja) * 2016-12-21 2020-05-21 ティーシーアール２ セラピューティクス インク． がん治療用に操作されたｔ細胞
WO2018232020A1 (en) * 2017-06-13 2018-12-20 TCR2 Therapeutics Inc. Compositions and methods for tcr reprogramming using fusion proteins
US11738047B2 (en) * 2017-12-12 2023-08-29 The Trustees Of The University Of Pennsylvania Genetically modified immune cells targeting NY-ESO-1 and methods of use thereof
WO2019133443A1 (en) * 2017-12-28 2019-07-04 Janux Therapeutics, Inc. Modified t cell receptors
MX2020009371A (es) * 2018-03-09 2021-01-08 Tcr2 Therapeutics Inc Composiciones y métodos para la reprogramación de tcr mediante el uso de proteínas de fusión.

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BR112022004458A2 (pt) 2022-05-31
CA3154287A1 (en) 2021-03-18
WO2021050948A1 (en) 2021-03-18
CN114828862A (zh) 2022-07-29
AU2020344628A1 (en) 2022-04-07
JP2022548866A (ja) 2022-11-22
MX2022002984A (es) 2022-06-16
IL291236A (en) 2022-05-01
EP4028033A1 (en) 2022-07-20
EP4028033A4 (en) 2023-10-04

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