KR20220057361A - Composition comprising titrated extract of Cetella asiatica for UV protection - Google Patents

Abstract

The present invention relates to an ultraviolet (UV)-blocking cosmetic composition including an organic UV-blocking agent having secured precipitation stability, higher alcohol, and a titrated extract of Centella asiatica (TECA). According to the present invention, the UV-blocking cosmetic composition including TECA, an organic UV-blocking agent, synthetic wax, an ethylene/propylene copolymer, and higher alcohol can include TECA, which is a poorly soluble component, without precipitation in the composition, thereby providing a cosmetic composition effective for blocking ultraviolet rays while increasing skin absorption of TECA ingredients inducing antioxidant effects and increase of collagen expression.

Description

Cosmetic composition comprising titrated extract of Cetella asiatica for UV protection

It relates to a UV-blocking cosmetic composition comprising an organic UV-blocking agent with secured precipitation stability, higher alcohol, and a quantitative extract of Centella asiatica.

Centella asiatica is also called centella, centella asiatica or tiger herb, and a titrated extract of Cetella asiatica (TECA) is used for various purposes in the field of medicine.

Centella asiatica extract contains asiaticoside, madecassic acid, and asiatic acid as main components, and exhibits therapeutic activity for skin wounds and chronic ulcers. The Centella asiatica extract is known to be effective in skin regeneration and moisturizing. In addition, in recent years, the demand for use as a material for functional cosmetics as well as pharmaceuticals is increasing.

However, since the main components of Centella asiatica extract are poorly soluble substances, they do not completely dissolve in any of the oil-soluble and water-soluble components, and are known as a component causing a precipitation problem in the formulation by starting with the initial particle formation and causing a precipitation problem in the formulation.

In order to solve this problem, an excessive amount of a thickener is used, the pH of the product is maintained below 5.0, or an excessive amount of ethanol is added.

Therefore, there is a need for development of a cosmetic composition for sunscreen that can be used in various formulations, particularly in the rapidly growing sunscreen market, and that stably maintains the solubility of TECA.

One aspect provides a cosmetic composition for sunscreen comprising a titrated extract of Cetella asiatica (TECA).

Another aspect provides a method for preparing the cosmetic composition.

One aspect provides a cosmetic composition for sunscreen comprising a titrated extract of Cetella asiatica (TECA), a polar oil, a synthetic wax, an ethylene/propylene copolymer, and a higher alcohol.

The titrated extract of Cetella asiatica (TECA) may include at least one selected from the group consisting of madecasic acid, asiaticoside and asiatic acid. The TECA may contain about 25 to 55% of madecassic acid, about 25 to 55% of asiaticoside, and about 5 to 35% of asiatic acid. The Centella asiatica extract may be obtained by diluting TECA with an appropriate solvent such as water or ethanol. The Centella asiatica extract may be commercially sold as a raw material for a pharmaceutical composition or a cosmetic composition. The Centella asiatica extract can be easily prepared by those skilled in the art according to the pharmaceutical standards of the Ministry of Food and Drug Safety and known extract preparation methods. The quantitative extract of Centella asiatica is known as a poorly soluble substance, but in one embodiment, the quantitative extract of Centella asiatica is dissolved in polar oil, which is an oily component with very high polarity, and is formulated by adding synthetic wax, ethylene/propylene copolymer and higher alcohol. Stabilization of the TECA-containing cosmetic composition was confirmed by lowering the fluidity resistance.

As used herein, the term “cosmetic composition” refers to an article used in the human body to clean and beautify the human body to add attractiveness, to brighten the appearance, or to maintain or promote health of skin and hair. The cosmetic composition may be for UV protection.

In the cosmetic composition, the higher alcohol may include at least one selected from the group consisting of cetyl alcohol, stearyl alcohol, behenyl alcohol, and batyl alcohol.

In addition, the polar oil may include at least one selected from the group consisting of an organic sunscreen and a sunscreen booster component. Specifically, the organic sunscreen is, for example, bis-ethylhexyloxyphenol methoxyphenyltriazine, Butylmethoxydibenzoylmethane, diethylaminohydroxybenzoylhexylbenzoate, disodiumphenyldibenzimidazoletetrasulfonate, dromethrazole trisiloxane, menthylanthranilate, methylenebis-benzotriazolyltetramethylbutylphenol, Terephthalylidene dicamphor sulfonic acid, terephthalylidene dicamphor sulfonic acid, benzophenone-3, benzophenone-4, polysilicon-15, ethylhexyltriazone, isoamyl p-methoxycinnamate, phenylbenzimidazole sulfonate It may be at least one selected from the group consisting of phonic acid, trisbisphenyltriazine, ethylhexyl salicylate, homosalate, ethylhexylmethoxycinnamate, and octocrylene. In addition, the UV blocking booster may include at least one selected from the group consisting of butyloctyl salicylate and acrylate copolymer. The polar oil is an oily component with very high polarity and can be used to dissolve TECA, a poorly soluble substance. Specifically, the polar oil is an organic sunscreen selected from the group consisting of ethylhexyl salicylate, homosalate, ethylhexyl methoxycinnamate, and octocrylene; and at least one sunscreen booster component selected from the group consisting of butyloctyl salicylate, and an acrylate copolymer.

The quantitative extract of Centella asiatica is about 0.01 to 10% by weight, 0.1 to 7% by weight, 0.2 to 5% by weight, 0.5 to 5% by weight, 0.7 to 3% by weight, 0.8 to 2% by weight, 0.9 or It may be included in an amount of 1.5% by weight. When the content of the quantitative extract of Centella asiatica is lower than the above content, the antioxidant effect and collagen expression increase effect do not appear in the cosmetic composition.

The polar oil is about 1 to 30% by weight, for example, 0.1 to 25% by weight, 1 to 25% by weight, 1 to 23% by weight, 5 to 20% by weight, 7 to 17% by weight, based on the total weight of the composition, It may be included in an amount of 7 to 15% by weight, or 8 to 12% by weight. If the content of the organic sunscreen is lower than the content, the TECA component is not well dissolved, and if the content is higher than the content, it is not suitable for application to the skin, so spreadability may be reduced.

The higher alcohol may be present in an amount of about 1 to 20% by weight, such as 2 to 10% by weight, 1 to 15% by weight, 1 to 10% by weight, 1 to 7% by weight, or 2 to 5% by weight based on the total weight of the composition. may be included in an amount. If the content of the higher alcohol is out of the above content, the fluidity of the cosmetic composition is not lowered and solidification does not occur, so particle formation of the TECA component is not prevented and TECA may be precipitated.

In addition to the ingredients described above, the cosmetic composition contains preservatives, stabilizers, surfactants, thickeners, solubilizers, humectants, emollients, UV absorbers, preservatives, disinfectants, emulsifiers, antioxidants, pH adjusters, organic and inorganic pigments, fragrances, cooling sensation It may further include additives commonly used in the art, such as agents or limiting agents. The blending amount of the additional ingredients such as the preservative can be easily selected by those skilled in the art within the range that does not impair the purpose and effect of the present invention, and the blending amount is about 0.001 to 30% (w/w) based on the total weight of the composition. However, one of ordinary skill in the art may select any additional ingredients and/or amounts thereof such that the advantageous properties of the composition according to the present disclosure are not adversely or substantially not adversely affected by the expected addition.

The "wax" is a generic term for a wax containing a synthetic material among an oil component that is solid at room temperature, for example, an alcohol fatty acid ester that is not soluble in water, and the synthetic wax refers to a low molecular weight polymer mixture of ethylene in the wax. do.

The cosmetic composition may be SLM (Soiled Lipid Microparticle), and specifically, the present formulation may refer to a formulation in which the oily component in which TECA is dissolved is solidified without an emulsifier and evenly dispersed in a water-based state such as aloe gel.

The cosmetic composition may not include an inorganic sunscreen. This means that the inorganic sunscreen is not included at all, but is also included in an effective amount generally acceptable in the art, that is, in an amount that does not significantly affect the physical properties of the composition because it is not included as an active ingredient. should be interpreted as Specifically, when the cosmetic composition contains less than 0.5%, 0.1%, 0.05%, 0.01%, or 0.001% of the inorganic sunscreen based on the total weight of the composition, it may be considered that the cosmetic composition does not contain the inorganic sunscreen.

The cosmetic composition is a lotion (skin lotion), skin softener, skin toner, astringent, lotion, milk lotion, moisture lotion, nourishing lotion, massage cream, cream, sun cream, nourishing cream, moisture cream, hand cream, foundation, essence, nutrition Essence, pack, soap, cleansing foam, cleansing lotion, cleansing cream, body lotion, body cleanser, suspension, gel, powder, paste, pact, mask pack or sheet or a formulation containing an aerosol composition. The composition of such a formulation can be prepared according to a method conventional in the art.

Another aspect is (a) mixing the polar oil, higher alcohol and Centella asiatica extract and heating to 65 to 90 ℃, followed by stirring to obtain a mixture; and

(b) cooling the mixture obtained in (a) to 50 to 70° C., adding synthetic wax, and ethylene/propylene copolymer, and stirring. It provides a method for preparing a sunscreen cosmetic composition.

The stirring in step (a) may include stirring while heating to about 65 to 90° C. using a homogenizer and an agitator.

The cooling of step (b) may be performed using a cooling bath in which a temperature of 50° C. to 70° C. is maintained, and cooling may be performed until the mixture reaches a desired temperature regardless of time. The cooling may be combined with an appropriate level of agitation of 20 to 40 rpm.

The stirring of step (b) may be performed by using a mixer of 500 to 2000 rpm for the mixture of step (a), 1 minute to 30 minutes, 2 minutes to 20 minutes, or 3 minutes to 10 minutes, etc. This can be done until the mixture is sufficiently mixed. In addition, step (b) may specifically include mixing with a synthetic wax having a temperature range of 50 to 70° C., and a water base containing an ethylene/propylene copolymer.

According to a cosmetic composition for UV protection comprising Titrated Extract of Cetella asiatica (TECA), organic sunscreen, synthetic wax, ethylene/propylene copolymer and higher alcohol and a method for preparing the same, TECA, a sparingly soluble component, is used in the composition Since it can be included without precipitation, it is possible to provide a cosmetic composition that is effective in blocking UV rays while improving the skin absorption of the TECA component that induces an antioxidant effect and an increase in collagen expression.

1 is a view showing the results of confirming the formulation stability of the cosmetic composition of the composition of Example 1 prepared according to an aspect (the left side is a storage temperature of 4°C, the right side is a diagram showing the storage temperature of 25°C).
2 is a view showing the results of confirming the formulation stability (FIG. 2B) of the cosmetic composition of the composition of Example 1 (FIG. 2A) and the cosmetic composition of the composition of Comparative Example 1 prepared according to an aspect.

Hereinafter, the present invention will be described in more detail through Examples and Test Examples. However, these Examples and Test Examples are for illustrative purposes of the present invention, and the scope of the present invention is not limited to these Examples and Test Examples.

1. Preparation of compositions of Examples and Comparative Examples

Example 1, which is a UV protection cosmetic composition containing TECA, synthetic wax, ethylene/propylene copolymer and higher alcohol, in polar oil containing organic UV protection agent and UV protection booster component, which are oily components with very high polarity, is shown in Table 1. The composition was prepared. In addition, a composition of Comparative Example 1 prepared by further including an inorganic sunscreen agent in the organic sunscreen agent was prepared according to the composition shown in Table 1 below.

ingredient Example 1 (wt%) Comparative Example 1 (wt%)) Purified water 60.9 59.9 homosalate 3 3 Octocrylene 3 3 Ethylhexyl Salicylate 3 3 behenyl alcohol 3.5 3.5 glycerin 5 5 Biosaccharide Gum-1 One One Butylmethoxydibenzoylmethane 3 3 niacinamide 2 2 ethanol 5 5 pentylene glycol One One Asiaticoside 0.4 0.4 Madecasic Acid 0.4 0.4 synthetic wax 0.3625 0.3625 Asian Acid 0.2 0.2 caprylyl glycol 0.2 0.2 Carbomer 0.5 0.5 tromethamine 0.4 0.4 Ethylene/propylene copolymer 0.1375 0.1375 1,2-Hexanediol 2 2 Butylene Glycol 5 5 Inorganic sunscreen ingredients - One total 100 100

An organic sunscreen, higher alcohol and Centella asiatica extract were mixed and stirred at a temperature of 75-80°C using a homogenizer and agitator. Then, the composition of Example 1 was prepared by cooling the synthetic wax and the ethylene/propylene copolymer to 70° C. while stirring the stirred mixture, adding a water base at 70° C., and mixing the mixture to solidify at room temperature. A cosmetic composition was prepared in the same manner as in Comparative Example 1, except that the composition further included an inorganic sunscreen in addition to the organic sunscreen.

Test Example 1. Confirmation of formulation stability of cosmetic composition containing TECA component

The formulation stability of the composition of Example 1 prepared in order to confirm that the TECA component, a component that does not completely dissolve in any of the oil-soluble and water-soluble components, and causes a precipitation problem in the formulation by starting with initial particle formation, can be dissolved in the composition An experiment was performed to confirm it, and the results of confirming the formulation thereof are shown in FIG. 1 .

As shown in FIG. 1 , the composition of Example 1 was prepared in an SLM formulation, and the TECA component in the trauma, mainly composed of transparent gel-like water-soluble components, was uniformly dissolved and dispersed, and it was confirmed that particles of the TECA component were not formed. Therefore, according to the composition of Example 1, it was confirmed that a cosmetic composition with high stability in which the TECA component does not precipitate can be prepared.

Test Example 2. Confirmation of long-term stability of cosmetic composition containing TECA component

An experiment was conducted to confirm formulation stability, ie, long-term stability, of the composition of Example 1 containing only the organic sunscreen agent without a thickener and surfactant, and the composition of Comparative Example 1 including the inorganic sunscreen agent. The results of visually confirming the formulation stability of the compositions of Example 1 and Comparative Example 1 are shown in FIGS. 2A and 2B.

In addition, an experiment was conducted to check whether the formulation stability appeared even after 1, 2, and 3 months after the prepared cosmetic composition was prepared according to the storage temperature. The method of confirming the stability of the formulation was confirmed through visual observation. Specifically, samples exposed to each temperature condition were collected and the presence or absence of precipitation was tested through particle observation and observation. In addition, the cycling experiment was performed under the conditions of 8 hours at 10°C, 8 hours at 25°C, and 8 hours at 45°C.

Example 1 The experimental results confirmed at 4 ℃ the formulation stability of the composition in Table 2, the experimental results confirmed at room temperature 25 ℃ in Table 3, the experimental results confirmed at 37 ℃ in Table 4, the experimental results confirmed in the cycling experiment Table 5 shows.

Comparative Example 1 The experimental results confirmed at 4 ℃ the formulation stability of the composition in Table 6, the experimental results confirmed at room temperature 25 ℃ in Table 7, the experimental results confirmed at 37 ℃ in Table 8, the experimental results confirmed in the cycling experiment Table 9 shows.

storage environment analysis method observation time immediately after manufacturing 1 month after manufacturing 2 months after manufacturing 3 months after manufacturing 4℃ formulation gel stability stability stability color White stability stability stability smell characteristic fragrance stability stability stability pH (25°C) 7.35 7.40 7.35 7.30 Viscosity (25℃) 19,000 19,050 18,850 18,800

storage environment analysis method observation time immediately after manufacturing 1 month after manufacturing 2 months after manufacturing 3 months after manufacturing room temperature formulation gel stability stability stability color White stability stability stability smell characteristic fragrance stability stability stability pH (25°C) 7.35 7.35 7.45 7.40 Viscosity (25℃) 19,000 19,100 19,000 18,800

storage environment analysis method observation time immediately after manufacturing 1 month after manufacturing 2 months after manufacturing 3 months after manufacturing 37℃ formulation gel stability stability stability color White stability stability stability smell characteristic fragrance stability stability stability pH (25°C) 7.35 7.35 7.30 7.15 Viscosity (25℃) 19,000 18,750 18,800 18,500

storage environment analysis method observation time immediately after manufacturing 1 month after manufacturing 2 months after manufacturing 3 months after manufacturing Cyling experiment formulation gel stability stability stability color White stability stability stability smell characteristic fragrance stability stability stability pH (25°C) 7.35 7.32 7.28 7.20 Viscosity (25℃) 19,000 18,900 18,850 18,750

storage environment analysis method observation time immediately after manufacturing 1 month after manufacturing 2 months after manufacturing 3 months after manufacturing 4℃ formulation creamy Instability Instability Instability color White Instability Instability Instability smell characteristic fragrance Instability Instability Instability pH (25°C) 7.50 7.65 7.65 7.70 Hardness (25℃) 10 11 11 11

storage environment analysis method observation time immediately after manufacturing 1 month after manufacturing 2 months after manufacturing 3 months after manufacturing room temperature formulation creamy Instability Instability Instability color White Instability Instability Instability smell characteristic fragrance Instability Instability Instability pH (25°C) 7.50 7.50 7.51 7.55 Hardness (25℃) 10 11 12 12

storage environment analysis method observation time immediately after manufacturing 1 month after manufacturing 2 months after manufacturing 3 months after manufacturing 37℃ formulation creamy Instability Instability Instability color White Instability Instability Instability smell characteristic fragrance Instability Instability Instability pH (25°C) 7.50 7.49 7.48 7.40 Hardness (25℃) 10 12 14 15

storage environment analysis method observation time immediately after manufacturing 1 month after manufacturing 2 months after manufacturing 3 months after manufacturing Cycling test formulation creamy Instability Instability Instability color White Instability Instability Instability smell characteristic fragrance Instability Instability Instability pH (25°C) 7.50 7.35 7.20 7.20 Hardness (25℃) 10 12 15 16

As confirmed in FIG. 2A, it was confirmed that the composition of Example 1 exhibited a stable formulation. In addition, as confirmed in Tables 2 to 5, it was confirmed that the formulation and color that could be visually confirmed up to 3 months after being prepared in all of the storage temperature 4 ℃, room temperature, 37 ℃ and cycling experiments were stable without change. It was confirmed that the odor also did not change after 3 months, and although there was a slight change in pH, it was confirmed that all of them maintained a neutral pH of 7. It was confirmed that the cosmetic composition of Example 1 including the TECA component prepared through this had excellent long-term stability of the composition itself regardless of the storage temperature.

On the other hand, as confirmed in FIG. 2B , in the composition of Comparative Example 1, the formulation of the cosmetic composition was creamy and appeared white, confirming that the cosmetic composition was not commercially available. In addition, it was confirmed that immediately after preparation, the oil base and the water base were separated, so that the stability of the formulation was low immediately after preparation. In addition, as confirmed in Tables 6 to 9, as a result of the stability observation, precipitation of TECA component was found at 4°C, room temperature, 37°C, and cycling tests after one month had elapsed. Dissolution of TECA component in the cosmetic composition does not appear, confirming that it cannot be done.

Claims (8)

A cosmetic composition for UV protection comprising Titrated Extract of Cetella asiatica (TECA), polar oil, synthetic wax, ethylene/propylene copolymer, and higher alcohol. The cosmetic composition of claim 1, wherein the quantitative extract of Centella asiatica comprises at least one selected from the group consisting of madecasic acid, asiaticoside and asiatic acid. The cosmetic composition according to claim 1, wherein the higher alcohol comprises at least one selected from the group consisting of cetyl alcohol, stearyl alcohol, behenyl alcohol, and batyl alcohol. The method according to claim 1, wherein the polar oil is
Bis-ethylhexyloxyphenol methoxyphenyltriazine, butylmethoxydibenzoylmethane, diethylaminohydroxybenzoylhexylbenzoate, disodiumphenyldibenzimidazoletetrasulfonate, dromethrizoletrisiloxane, menthylanthranilate, Methylenebis-benzotriazolyltetramethylbutylphenol, terephthalylidene dicamphor sulfonic acid, terephthalylidene dicamphor sulfonic acid, benzophenone-3, benzophenone-4, polysilicon-15, ethylhexyltriazone, isoamyl At least one selected from the group consisting of p-methoxycinnamate, phenylbenzimidazole sulfonic acid, trisbisphenyltriazine, ethylhexylsalicylate, homosalate, ethylhexylmethoxycinnamate, and octocrylene organic sunscreen; and
Butyloctyl salicylate, and at least one UV blocking booster component selected from the group consisting of acrylate copolymers;
A cosmetic composition comprising at least one selected from the group consisting of. The method according to claim 1, based on the total weight of the composition
The quantitative extract of Centella asiatica is 0.01 to 10% by weight,
1 to 30% by weight of the polar oil, and
The higher alcohol is a cosmetic composition comprising 1 to 20% by weight. The cosmetic composition of claim 1, wherein the cosmetic composition is a SLM (Soild Lipid Microparticle) formulation. The cosmetic composition according to claim 1, wherein the composition does not contain an inorganic sunscreen. (a) mixing polar oil, higher alcohol and Centella asiatica extract and heating to 65 to 90° C., followed by stirring to obtain a mixture; and
(b) cooling the mixture obtained in (a) to 50 to 70° C., adding synthetic wax, and ethylene/propylene copolymer, and stirring.

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