KR20220056452A - Deep eutectic solvent for extracting cosmetic ingredients and method for extracting cosmetic ingredients using the same - Google Patents

Abstract

The present invention relates to a eutectic solvent for extracting cosmetic raw materials, composed of a salt of choline represented by chemical formula 1 and a hydrogen bond donor. In the chemical formula 1, X is any one of chlorine (Cl), bromine (Br), or iodine (I). According to the present invention, the eutectic solvent has renewable biodegradability and environmentally friendly properties.

Description

Eutectic solvent for cosmetic raw material extraction and cosmetic raw material extraction method using the same { DEEP EUTECTIC SOLVENT FOR EXTRACTING COSMETIC INGREDIENTS AND METHOD FOR EXTRACTING COSMETIC INGREDIENTS USING THE SAME }

The present invention relates to a eutectic solvent for extracting cosmetic raw materials and a method for extracting cosmetic raw materials using the same, and more particularly, polyphenol or madecassoside (Polyphenol) from Centella asiatica using a deep eutectic solvent. Madecassoside), it relates to a eutectic solvent for extracting cosmetic raw materials that enables extraction of any one or more in an environmentally friendly manner, and to a cosmetic raw material extraction method using the same.

Recently, as interest in the environment increases, room temperature ionic liquids are receiving great attention industrially and academically.

Room temperature ionic liquid is a substance that exists as a salt in a liquid state and is composed of cations and anions.

Room temperature ionic liquid has a low vapor pressure and a high boiling point, so it is used for pretreatment of biological resources such as cellulose, and is being actively studied as an eco-friendly green solvent that replaces toxic volatile organic solvents.

However, room temperature ionic liquids do not have biodegradable properties and have a certain toxicity problem, and even when a very small amount of impurities are present, their physical properties change and high purity is required.

In addition, since many organic solvents and chemicals are used in the process of manufacturing high-purity room temperature ionic liquid, the high-purity room temperature ionic liquid manufacturing process is not environmentally friendly at all. there is.

In order to solve the problem of toxicity and pollution of such organic solvents and room temperature ionic liquids, it is non-toxic and recyclable, and hydrogen bonds between ionic substances at relatively low temperatures Deep eutectic solvents, which can be easily manufactured through

A deep eutectic solvent is characterized in that one or more solid compounds and other specific compounds can be mixed to form a liquid state. That is, while the eutectic solvent is generally liquid at room temperature, at least one solid compound constituting the deep eutectic solvent has a characteristic of having a solid state at room temperature.

The melting point is lowered by the formation of a deep eutectic solvent, which is due to intermolecular hydrogen bonding between one or more solid compounds and a specific compound. That is, as intermolecular hydrogen bonds are strongly formed between one or more solid compounds and a specific compound, the volume of space within the one or more solid compounds increases and mobility increases to lower the melting point, and a deep eutectic solvent Allow it to exist as a liquid at room temperature.

That is, a deep eutectic solvent is a solvent that exists as a liquid at room temperature through hydrogen bonding between two or more compounds having a high melting point, and is oxygen (O, Oxygen), nitrogen (N, Nitrogen) or fluorine (F, Fluorine) containing hydrogen bond donor (Hydrogen bond donor, HBD) and hydrogen (H, Hydrogen) such as amide, organic acid, alcohol or saccharide (Saccharide) ) is composed of a hydrogen bond acceptor (HBA).

A deep eutectic solvent is easier to manufacture compared to room temperature ionic liquid, has a lower production cost, and is a renewable, biodegradable solvent. have

-글루코시다아제 효소를 가하여 효소반응시키는 단계; 및 D) 상기 효소반응 완료 후 여과하는 단계를 포함하는 꽃 혼합추출물의 제조방법로 구성되며, 상기 테인(Betaine)과 사카로즈(Saccharose)로 이루어지는 천연 공융 용매를 사용하여 혼합추출물을 제조하는 경우 그 활성이 증대되어 우수한 피부보습, 항균, 진정, 재생 및 주름개선 효능을 나타내는 특징을 개시하고 있다.Patent Document 1 relates to a cosmetic composition containing a flower mixed extract extracted with a natural eutectic solvent, A) dried forsythia, rape flower, daffodil, dandelion flower, bristle flower, magnolia flower, peony, plum flower, camellia Flowers, Cerulata cherry blossoms and Purmeria rubra flowers were mixed in a weight ratio of 1:3:3:3:1:1:1:1:3:1:1, respectively, and mixed with water, anhydrous or Extracting with at least one extraction solvent selected from the group consisting of hydrous alcohol, ethyl acetate, acetone, glycerin, ethanol, propylene glycol and butylene glycol; B) re-extracting the extract prepared in the above step with a solvent mixed with a natural eutectic solvent consisting of betaine and saccharose and water in a weight ratio of 0.5 to 2:10, respectively; C) in the extract prepared in step B)

- Enzymatic reaction by adding a glucosidase enzyme; And D) is composed of a method for producing a mixed extract of flowers comprising the step of filtration after completion of the enzymatic reaction, when the mixed extract is prepared using a natural eutectic solvent consisting of the above-mentioned betaine and saccharose Disclosed are the characteristics of exhibiting excellent skin moisturizing, antibacterial, soothing, regenerating and anti-wrinkle effects due to increased activity.

However, in the case of the technique disclosed in Patent Document 1, an organic solvent, such as anhydrous or hydrous alcohol having 1 to 4 carbon atoms, ethyl acetate, acetone, glycerin, ethanol, propylene glycol and butylene glycol, etc. There is a problem that the solvent is toxic and causes environmental pollution and is not environmentally friendly.

Korean Patent Publication No. 10-1901451 (Registered on September 17, 2018)

In solving the above problems, an object of the present invention is to provide a eutectic solvent for extracting cosmetic raw materials that is easy to manufacture, has a low production cost, has renewable biodegradability, and is non-volatile and non-toxic and thus eco-friendly. is in providing.

In addition, it is an object of the present invention to provide a eutectic solvent for extracting cosmetic raw materials that enables extracting a large amount of cosmetic raw materials in an environmentally friendly manner compared to conventional solvents in extracting cosmetic raw materials from Centella asiatica.

In addition, it is an object of the present invention to provide a eutectic solvent for extracting cosmetic raw materials that ensures superior extraction performance than conventional solvents in extracting polyphenol or madecassoside from Centella asiatica. .

In addition, an object of the present invention is to present a new cosmetic raw material extraction methodology for extracting polyphenol or madecassoside from Centella asiatica by using the eutectic solvent for extracting cosmetic raw materials as described above, thereby improving process efficiency and An object of the present invention is to provide a cosmetic raw material extraction method that improves economic feasibility.

The eutectic solvent for extracting cosmetic raw materials according to an embodiment of the present invention comprises a salt of choline having the following Chemical Formula 1 and a hydrogen bond donor.

[Formula 1]

(In Formula 1, X is any one of fluorine (F), chlorine (Cl), bromine (Br), or iodine (I).)

In this case, the cosmetic raw material is preferably extracted from Centella asiatica.

In this case, the cosmetic raw material preferably includes at least one of polyphenol or Madecassoside extracted from Centella asiatica.

Meanwhile, the hydrogen bond donor is preferably at least one of glycerol, xylitol, and glucose.

In this case, the salt of choline and the hydrogen bond donor are preferably mixed in a molar ratio of 1:2 to 3:1 (salt of choline: hydrogen bond donor).

In this case, the hydrogen bond donor is glycerol, and the hydrogen bond donor composed of the salt of choline and glycerol is more preferably mixed in a molar ratio of 1:1.

In addition, the hydrogen bond donor is xylitol, and the hydrogen bond donor composed of the choline salt and xylitol is more preferably mixed in a molar ratio of 5:2.

In addition, the hydrogen bond donor is glucose, and the hydrogen bond donor composed of the choline salt and glucose is more preferably mixed in a molar ratio of 1:1.

On the other hand, the cosmetic raw material extraction method according to an embodiment of the present invention comprises the steps of preparing Centella asiatica and treating the Centella asiatica with a eutectic solvent for extracting cosmetic raw materials, and the cosmetic raw material The eutectic solvent for extraction is composed of a salt of choline having the following formula (1) and a hydrogen bond donor.

[Formula 1]

(In Formula 1, X is any one of fluorine (F), chlorine (Cl), bromine (Br), or iodine (I).)

In this case, the cosmetic raw material preferably includes at least one of polyphenol or Madecassoside extracted from Centella asiatica.

As described above, the eutectic solvent for extracting cosmetic raw materials according to the present invention is easy to manufacture, has a low production cost, has renewable biodegradability, and is non-volatile and non-toxic, thereby promoting the advantages of being environmentally friendly.

In addition, the eutectic solvent for extracting cosmetic raw materials according to the present invention makes it possible to extract a large amount of cosmetic raw materials in an environmentally friendly manner compared to conventional solvents in extracting cosmetic raw materials from Centella asiatica.

In addition, the eutectic solvent for extracting cosmetic raw materials according to the present invention secures better extraction performance than conventional solvents in extracting polyphenol or madecassoside from Centella asiatica.

In addition, the cosmetic raw material extraction method according to the present invention proposes a new cosmetic raw material extraction methodology for extracting polyphenol or madecassoside from Centella asiatica using the eutectic solvent for extracting cosmetic raw materials as described above. This improves process efficiency and economic feasibility.

1 is a liquid chromatography-series for Experimental Group 2 and Control 1, in order to compare the content of Madecassoside extracted from Centella asiatica with an organic solvent using a eutectic solvent for extracting cosmetic raw materials according to an embodiment of the present invention; This is a chromatogram obtained by separating and analyzing components using mass spectrometry (LC-MS/MS).
2 is a flowchart illustrating a cosmetic raw material extraction method according to an embodiment of the present invention.

In the present invention, the accompanying drawings may be shown in exaggerated expressions for the convenience of understanding the technology, and for differentiation and clarity from the prior art. In addition, the terms described below are terms defined in consideration of functions in the present invention, and may vary depending on the intention or custom of the user or operator, so definitions of these terms should be made based on the technical content throughout this specification. will be. On the other hand, experimental examples or embodiments are merely exemplary matters of the components presented in the claims of the present invention, do not limit the scope of the present invention, the scope of the rights is based on the technical idea throughout the specification of the present invention should be interpreted

In the present invention, the deep eutectic solvent refers to a eutectic mixture in which two types of components are mixed and has a lower melting point than each component, and is mainly present in a liquid state at 100° C. or less. The eutectic solvent has characteristics similar to that of a room temperature ionic liquid in physical and chemical properties such as viscosity, density, conductivity and solubility, and by changing the properties of the ammonium salt and the hydrogen bond donor to fine-tune the physical and chemical properties Customized eutectic solvents can be made for various purposes.

Accordingly, the inventors of the present invention use various hydrogen bond donors (HBD) and various hydrogen bond acceptors (HBA) to proceed with the cosmetic raw material extraction process, and select a suitable eutectic solvent for cosmetic raw material extraction did

Eutectic solvents suitable for extracting cosmetic raw materials should not have toxic or odor in the extracted extract.

[Experimental Example 1]

1 g of Centella asiatica is pulverized to 8 mm, a solvent having the composition of [Table 2] is prepared using the substances listed in [Table 1] below, and the extraction process is performed using each solvent It was judged whether there was a problem, and an eutectic solvent suitable for extracting cosmetic raw materials was selected.

division Molecular Weight Based on 0.01 mol Chloline Chloride 139.62 1.3962 Glycerol 92.094 0.92094 Xylitol 152.15 1.5215 Citric acid 192.1265 1.921265 D-(+)-Glucose 180.1572 1.801572 DL-Malic acid 134.09 1.3409 Betine 117.1489 1.171489 L-Proline 115.133 1.15133 Adonitol 152.1484 1.521484

division Chloline Chloride+Glycerol Chloline Chloride+Xylitol Chloline Chloride+D-(+)-Glucose L-Proline+D-(+)-Glucose Citric acid+ D-(+)-Glucose Citric acid + Adonitol Betine+DL-Malic acid Mole ratio 1:1 5:2 1:1 5:3 1:1 1:1 1:1 Amount of solvent (based on 0.01 mol) 2.31714 10.024 3.197772 11.131366 3.722837 3.442749 2.512389 Toxic and odor absence absence absence existence existence existence existence

A solvent having the composition of [Table 2] was prepared using the substances shown in [Table 1], and after performing the extraction process for Centella asiatica using each solvent, it was determined whether there were problems such as toxicity and odor in the extract, In the case of extracts extracted from Centella asiatica using a eutectic solvent containing a salt of choline, there is no toxicity or odor, so a process in which a eutectic solvent containing a salt of choline is used to extract cosmetic raw materials from Centella asiatica It was judged to be a suitable eutectic solvent for

[Experimental Example 2]

Experimental group 1 was a eutectic solvent in which choline chloride and glycerol were mixed in a molar ratio of 1:1, and a eutectic solvent in which choline chloride and xylitol were mixed in a molar ratio of 5:2. As Experimental Group 2, a eutectic solvent in which choline chloride and glucose (D-(+)-Glucose) were mixed in a molar ratio of 1:1 was named Experimental Group 3, and butylene glycol (Butylene) that was subjected to ultrasonic treatment in parallel Glycol) solvent was designated as Control 1, and hot water extraction was designated as Control 2.

1 g of Centella asiatica was crushed to 8 mm, and cosmetic raw materials were extracted from Centella asiatica using the eutectic solvent and organic solvent of Experimental Group 1, Experimental Group 2, Experimental Group 3, Control 1 and Control 2 above.

Using UV/Vis Spectrometry for the extracted cosmetic raw materials, the absorbance of polyphenols was measured at the concentrations shown in [Table 3] below, and the results are shown in [Table 3], and the content of polyphenols is shown in [Table 4].

Sample name Measured concentration Absorbance [mg/L] [mg/mL] Experimental group 1 0.885 0.000885 0.078 Experimental group 2 1.346 0.001346 0.119 Experimental group 3 1.008 0.001008 0.089 Control 1 0.588 0.000588 0.052 Control 2 0.557 0.000557 0.049

* Measurement of the absorbance of polyphenols was performed by the Folin-Ciocalteu method (refer to the test method for health functional food standards and specifications) using UV/Vis Spectrometry.

Sample name Analysis items unit result Experimental group 1 total polyphenols mg/100g 42.75 Experimental group 2 total polyphenols mg/100g 50.90 Experimental group 3 total polyphenols mg/100g 50.03 Control 1 total polyphenols mg/100g 27.59 Control 2 total polyphenols mg/100g 27.19

* Analysis method: Specialized test method for health functional food standards and specifications * Analysis equipment: UV/Vis Spectrometry

* Limits of Quantitation: Analyzable Results

* Non-detection: Not detected (<Limit of quantitation)

According to [Table 4], a eutectic solvent in which choline chloride and glycerol are mixed in a molar ratio of 1:1 (experimental group 1), and choline chloride and xylitol in a molar ratio of 5:2 Cosmetic raw materials extracted using a eutectic solvent (experimental group 2) mixed with It was confirmed to have about 57.9%-87.2% higher polyphenol content than cosmetic raw materials extracted using butylene glycol organic solvent (control group 1) and hot water extraction (control group 2) in parallel with treatment. .

[Experimental Example 3]

Extracted using a eutectic solvent (experimental group 2) mixed with choline chloride and xylitol in a molar ratio of 5:2 and butylene glycol organic solvent (control group 1) in parallel with sonication For cosmetic raw materials, using liquid chromatography-series mass spectrometry (LC-MS/MS), the content of Madecassoside per sample was measured under the following analytical conditions and the concentration gradient in Table 5.

gradient Time(min) B% One 0 5 2 30 100 3 32 100

* LC-MS/MS analysis conditions

Instrument: Agilent Technologies 6410 Triple Quad (LC-MS/MS)

Column: Kromasil C18 (3.0mm×150mm, 3.0㎛)

Solvent: A; 0.1% Formic acid in Water, B; 0.1% Formic acid in Acetonitrile

Flow rate: 0.4mL/min

Injection vol.: 5 μl

1 is a liquid chromatography-series for Experimental Group 2 and Control 1, in order to compare the content of Madecassoside extracted from Centella asiatica with an organic solvent using a eutectic solvent for extracting cosmetic raw materials according to an embodiment of the present invention. This is a chromatogram obtained by separating and analyzing components using mass spectrometry (LC-MS/MS).

By analyzing the chromatogram of Figure 1, a eutectic solvent (experimental group 2) in which choline chloride and xylitol are mixed in a molar ratio of 5:2 (Experimental group 2) and butylene glycol organic solvent in parallel with ultrasonication [Table 6] shows the contents of madecassoside per sample for cosmetic raw materials extracted using (control group 1).

sample content per sample Area Madecassoside (μg/ml) Experimental group 2 4,255,389 19.29 Control 1 2,576,952 11.36

According to [Table 6], in cosmetic raw materials extracted using a eutectic solvent (experimental group 2) mixed with choline chloride and xylitol in a molar ratio of 5:2, 19.29㎍/㎖ of madecassoside ( Madecassoside) content, madecasso improved by about 69.8% compared to 11.36㎍/㎖ of Madecassoside content in cosmetic raw materials extracted using Butylene Glycol organic solvent (control 1) concurrently with sonication It was confirmed to have a side (Madecassoside) content.

According to the results of the above experimental examples, the eutectic solvent containing a salt of choline and a hydrogen bond donor has advantages of no toxicity and odor compared to other eutectic solvents, and choline chloride and a hydrogen bond donor The cosmetic raw materials extracted using Experimental Group 1, Experimental Group 2, and Experimental Group 3 including the containing organic solvent and hot water have about 57.9%-87.2% higher polyphenol content than the cosmetic raw materials extracted using Control 1 and Control 2 using organic solvent and hot water. , The cosmetic raw material extracted using Experimental Group 2, which was a mixture of Chloline Chloride and Xylitol, was madecassoside rather than the cosmetic raw material extracted using Control 1 of Butylene Glycol in parallel with ultrasonic treatment. (Madecassoside) content was found to be about 69.8% higher.

The eutectic solvent for extracting cosmetic raw materials according to an embodiment of the present invention comprises a salt of choline having the following Chemical Formula 1 and a hydrogen bond donor.

[Formula 1]

(In Formula 1, X is any one of fluorine (F), chlorine (Cl), bromine (Br), or iodine (I).)

That is, the eutectic solvent for extracting cosmetic raw materials according to an embodiment of the present invention uses a salt of choline as an ammonium salt. The salt of choline may be a salt in which choline having [Formula 1] and a halogen X atom, which is a group 17 element on the periodic table, are combined, preferably, the X atom is fluorine (F). It may be any one of chlorine (Cl), bromine (Br), or iodine (I). Even more preferably, the X atom may be chlorine (Cl).

Meanwhile, the hydrogen bond donor is preferably at least one of glycerol, xylitol, and glucose.

Meanwhile, the cosmetic raw material is preferably extracted from Centella asiatica. Cosmetic raw materials extracted from Centella asiatica promote collagen synthesis through anti-inflammatory action and have excellent skin regeneration effects.

In this case, the cosmetic raw material preferably includes at least one of polyphenol or Madecassoside extracted from Centella asiatica. Polyphenols contained in cosmetic ingredients have an antioxidant effect, which prevents skin aging, and reduces inflammation to soothe the skin. Madecassoside contained in cosmetic raw materials has an effect of increasing skin elasticity by promoting collagen synthesis through anti-inflammatory action, and has an effect of calming the skin by reducing inflammation.

In the eutectic solvent for extracting cosmetic raw materials according to an embodiment of the present invention, the salt of choline and the hydrogen bond donor may be mixed in a molar ratio of preferably 1:2 to 3:1 (salt of choline: hydrogen bond donor). When the ratio is out of the above ratio, an appropriate hydrogen bond is not formed between the salt of choline and the hydrogen bond donor, so the melting point of the eutectic solvent for extracting cosmetic raw materials according to an embodiment of the present invention rises and can be converted into a solid phase, There may be a problem of losing the unique properties of the eutectic solvent for extracting cosmetic raw materials.

More preferably, choline chloride (Chloline Chloride) and glycerol (Glycerol) according to an embodiment of the present invention may be mixed in a molar ratio of 1:1, and choline chloride (Chloline Chloride) and xylitol (Xylitol) are 5:2 may be mixed in a molar ratio of , and choline chloride (Chloline Chloride) and glucose (D-(+)-Glucose) may be mixed in a molar ratio of 1:1. When the composition and ratio are out of the above, it was experimentally confirmed that the polyphenol content and Madecassoside content of the cosmetic raw material extracted using the eutectic solvent decreased.

2 is a flowchart illustrating a cosmetic raw material extraction method according to an embodiment of the present invention.

2, the cosmetic raw material extraction method according to an embodiment of the present invention includes the steps of preparing Centella asiatica (S100) and treating the Centella asiatica with a eutectic solvent for extracting cosmetic raw materials (S200). ), and the eutectic solvent for extracting cosmetic raw materials is characterized in that it includes a salt of choline having the following formula (1) and a hydrogen bond donor.

[Formula 1]

(In Formula 1, X is any one of fluorine (F), chlorine (Cl), bromine (Br), or iodine (I).)

The cosmetic raw material preferably includes any one or more of polyphenol or Madecassoside extracted from Centella asiatica.

The step of preparing the Centella asiatica (S100) may be a step of washing Centella asiatica and pulverizing it to an appropriate size. In this case, Centella asiatica is preferably ground to a size of 5mm-15mm.

In the step (S200) of treating Centella asiatica with a eutectic solvent for extracting cosmetic raw materials, the eutectic solvent breaks and swells intermolecular bonds existing in the crushed Centella asiatica, and the eutectic solvent and Centella asiatica By forming a hydrogen bond between cosmetic raw materials, it may be a step of extracting any one or more of polyphenols or madecassoside, which are cosmetic raw materials.

As described above, the eutectic solvent for extracting cosmetic raw materials according to the present invention is easy to manufacture, has a low production cost, has renewable biodegradability, is non-volatile and non-toxic, and thus promotes the advantages of being environmentally friendly, and Centella In extracting cosmetic raw materials from asiatica, it is possible to extract a large amount of cosmetic raw materials in an environment-friendly way compared to conventional solvents, and in extracting polyphenol or madecassoside from Centella asiatica It ensures better extraction performance than conventional solvents.

In addition, the cosmetic raw material extraction method according to the present invention proposes a new cosmetic raw material extraction methodology for extracting polyphenol or madecassoside from Centella asiatica using the eutectic solvent for extracting cosmetic raw materials as described above. This improves process efficiency and economic feasibility.

As described above, the present invention has been described with reference to various experimental examples and examples, but these are merely exemplary, and various modifications and equivalent other embodiments are possible based on common knowledge in the field to which the subject technology belongs. should understand Therefore, the true technical protection scope of the present invention depends on the claims to be described below, and should be determined based on the specific content of the above-described invention.

The present invention relates to a eutectic solvent for extracting cosmetic raw materials and a cosmetic raw material extraction method using the same, and can be used in industrial fields related to cosmetic manufacturing.

Claims (10)

A eutectic solvent for extracting cosmetic raw materials comprising a salt of choline having the following formula (1) and a hydrogen bond donor.
[Formula 1]

(In Formula 1, X is any one of fluorine (F), chlorine (Cl), bromine (Br), or iodine (I).)
According to claim 1, wherein the cosmetic raw material,
A eutectic solvent for extracting cosmetic raw materials, characterized in that it is extracted from Centella asiatica.
According to claim 2, wherein the cosmetic raw material,
The eutectic solvent for extracting cosmetic raw materials, characterized in that it contains any one or more of polyphenol or madecassoside extracted from the centella asiatica.
According to claim 1, wherein the hydrogen bond donor,
A eutectic solvent for extracting cosmetic raw materials, characterized in that at least one of glycerol, xylitol, and glucose.
According to claim 4, wherein the salt of choline and the hydrogen bond donor,
A eutectic solvent for extracting cosmetic raw materials, characterized in that it is mixed in a molar ratio of 1:2 to 3:1.
5. The method of claim 4,
The hydrogen bond donor is
It is glycerol (Glycerol),
The hydrogen bond donor of the salt of choline and glycerol,
A eutectic solvent for extracting cosmetic raw materials, characterized in that it is mixed in a molar ratio of 1:1.
5. The method of claim 4,
The hydrogen bond donor is
Xylitol, and
The hydrogen bond donor of the salt of choline and xylitol is,
A eutectic solvent for extracting cosmetic raw materials, characterized in that it is mixed in a molar ratio of 5:2.
5. The method of claim 4,
The hydrogen bond donor is
is glucose,
The hydrogen bond donor composed of the salt of choline and glucose is,
A eutectic solvent for extracting cosmetic raw materials, characterized in that it is mixed in a molar ratio of 1:1.
Preparing Centella asiatica; and
Including; treating the centella asiatica with a eutectic solvent for extracting cosmetic raw materials;
The eutectic solvent for extracting cosmetic raw materials, a cosmetic raw material extraction method comprising a salt of choline having the following formula (1) and a hydrogen bond donor.
[Formula 1]

(In Formula 1, X is any one of fluorine (F), chlorine (Cl), bromine (Br), or iodine (I).)
10. The method of claim 9, wherein the cosmetic raw material,
The cosmetic raw material extraction method, characterized in that it comprises any one or more of polyphenol or madecassoside extracted from the centella asiatica.

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