KR20220020332A - 항-cd19 항체 약물 접합체 및 pi3k 억제제 또는 2차 제제를 포함하는 조합 요법 - Google Patents

항-cd19 항체 약물 접합체 및 pi3k 억제제 또는 2차 제제를 포함하는 조합 요법 Download PDF

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Publication number
KR20220020332A
KR20220020332A KR1020227000169A KR20227000169A KR20220020332A KR 20220020332 A KR20220020332 A KR 20220020332A KR 1020227000169 A KR1020227000169 A KR 1020227000169A KR 20227000169 A KR20227000169 A KR 20227000169A KR 20220020332 A KR20220020332 A KR 20220020332A
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South Korea
Prior art keywords
treatment
subject
adc
agent
pi3k inhibitor
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Pending
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KR1020227000169A
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English (en)
Korean (ko)
Inventor
프란체스카 자마치
프란체스코 베르토니
Original Assignee
에이디씨 테라퓨틱스 에스에이
메드임뮨 리미티드
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Priority claimed from GBGB1908234.6A external-priority patent/GB201908234D0/en
Priority claimed from GBGB1908233.8A external-priority patent/GB201908233D0/en
Application filed by 에이디씨 테라퓨틱스 에스에이, 메드임뮨 리미티드 filed Critical 에이디씨 테라퓨틱스 에스에이
Publication of KR20220020332A publication Critical patent/KR20220020332A/ko
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    • A—HUMAN NECESSITIES
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
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    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/68035—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a pyrrolobenzodiazepine
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
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    • A—HUMAN NECESSITIES
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    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
KR1020227000169A 2019-06-10 2020-06-08 항-cd19 항체 약물 접합체 및 pi3k 억제제 또는 2차 제제를 포함하는 조합 요법 Pending KR20220020332A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB1908234.6A GB201908234D0 (en) 2019-06-10 2019-06-10 Combination therapy
GBGB1908233.8A GB201908233D0 (en) 2019-06-10 2019-06-10 Combination therapy
GB1908233.8 2019-06-10
GB1908234.6 2019-06-10
PCT/EP2020/065880 WO2020249528A1 (en) 2019-06-10 2020-06-08 Combination therapy comprising an anti-cd19 antibody drug conjugate and a pi3k inhibitor or a secondary agent

Publications (1)

Publication Number Publication Date
KR20220020332A true KR20220020332A (ko) 2022-02-18

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KR1020227000169A Pending KR20220020332A (ko) 2019-06-10 2020-06-08 항-cd19 항체 약물 접합체 및 pi3k 억제제 또는 2차 제제를 포함하는 조합 요법

Country Status (11)

Country Link
US (1) US20220305132A1 (https=)
EP (1) EP3980079A1 (https=)
JP (1) JP7740994B2 (https=)
KR (1) KR20220020332A (https=)
CN (1) CN114302745A (https=)
AU (1) AU2020292965A1 (https=)
CA (1) CA3142645A1 (https=)
IL (1) IL288716B2 (https=)
MX (1) MX2021015403A (https=)
SG (1) SG11202113092WA (https=)
WO (1) WO2020249528A1 (https=)

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EP4565217A1 (en) * 2022-08-04 2025-06-11 Institut National de la Santé et de la Recherche Médicale Methods for the treatment of lymphoproliferative disorders
JP2025531798A (ja) * 2022-09-09 2025-09-25 上海▲瑛▼黎薬業有限公司 含窒素複素環化合物、その医薬組成物および使用
US12609718B2 (en) 2023-06-14 2026-04-21 Hewlett Packard Enterprise Development Lp WiFi-7 optimized split band architecture and method of operation

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BRPI0713119A2 (pt) * 2006-06-30 2012-04-17 Schering Corp piperidinas substituìdas que aumentam a atividade de p53 e os usos destas
RU2015141713A (ru) * 2010-03-25 2018-12-28 Эббви Инк. Средства, индуцирующие апоптоз, для лечения рака, иммунных и аутоиммунных заболеваний
EP2550975A1 (en) * 2011-07-29 2013-01-30 Sanofi Combination therapy for the treatment of CD19+ B-cell malignancies symptoms comprising an anti-CD19 maytansinoid immunoconjugate and rituximab
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HRP20182129T1 (hr) * 2012-10-12 2019-02-08 Adc Therapeutics Sa Konjugati protutijelo - pirolobenzodiazepin
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JP2025507736A (ja) * 2022-02-28 2025-03-21 アーデーセー セラピューティクス ソシエテ アノニム 投薬レジメン

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AU2020292965A1 (en) 2022-01-27
JP2022535609A (ja) 2022-08-09
IL288716A (en) 2022-02-01
EP3980079A1 (en) 2022-04-13
WO2020249528A1 (en) 2020-12-17
SG11202113092WA (en) 2021-12-30
JP7740994B2 (ja) 2025-09-17
CN114302745A (zh) 2022-04-08
MX2021015403A (es) 2022-01-24
CA3142645A1 (en) 2020-12-17
IL288716B2 (en) 2026-04-01
US20220305132A1 (en) 2022-09-29
IL288716B1 (en) 2025-12-01

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