KR20210125048A - 인산화 타우 펩티드 백신의 안전한 투여 방법 - Google Patents

인산화 타우 펩티드 백신의 안전한 투여 방법 Download PDF

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KR20210125048A
KR20210125048A KR1020217028336A KR20217028336A KR20210125048A KR 20210125048 A KR20210125048 A KR 20210125048A KR 1020217028336 A KR1020217028336 A KR 1020217028336A KR 20217028336 A KR20217028336 A KR 20217028336A KR 20210125048 A KR20210125048 A KR 20210125048A
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seq
nmole
tau
per dose
liposome
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Korean (ko)
Inventor
안드레아 파이퍼
안드레아스 뮤스
마리아 필그렌 보쉬
마리야 부키체비치 베르힐레
니콜라스 피오트
사로즈 라지 지미레
엘리자베스 앤 람스부르그
도나타 드 마르코
샬럿 사다카
Original Assignee
에이씨 이뮨 에스.에이.
얀센 파마슈티칼즈, 인코포레이티드
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Publication of KR20210125048A publication Critical patent/KR20210125048A/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0007—Nervous system antigens; Prions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55516—Proteins; Peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6018—Lipids, e.g. in lipopeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
    • A61K2039/627—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier characterised by the linker

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
KR1020217028336A 2019-02-08 2020-02-07 인산화 타우 펩티드 백신의 안전한 투여 방법 Pending KR20210125048A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962802870P 2019-02-08 2019-02-08
US62/802,870 2019-02-08
PCT/US2020/017235 WO2020163730A2 (en) 2019-02-08 2020-02-07 Method of safe administration of phosphorylated tau peptide vaccine

Publications (1)

Publication Number Publication Date
KR20210125048A true KR20210125048A (ko) 2021-10-15

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KR1020217028336A Pending KR20210125048A (ko) 2019-02-08 2020-02-07 인산화 타우 펩티드 백신의 안전한 투여 방법

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Country Link
US (3) US11684576B2 (https=)
EP (1) EP3920966A2 (https=)
JP (2) JP7541527B2 (https=)
KR (1) KR20210125048A (https=)
CN (1) CN113710269A (https=)
AU (1) AU2020219804A1 (https=)
BR (1) BR112021014794A2 (https=)
CA (1) CA3129252A1 (https=)
EA (1) EA202192203A1 (https=)
IL (1) IL285163B2 (https=)
JO (1) JOP20210211A1 (https=)
MX (1) MX2021009508A (https=)
MY (1) MY206596A (https=)
PH (1) PH12021551876A1 (https=)
SG (1) SG11202108312PA (https=)
TW (1) TWI868106B (https=)
WO (1) WO2020163730A2 (https=)

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WO2021056064A1 (en) * 2019-09-23 2021-04-01 Macquarie University Treatment of tauopathies
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CA3228878A1 (en) * 2021-08-12 2023-02-16 Andrea Pfeifer Liposomes containing phosphorylated tau peptides for inducing sustained immune responses
US20250134991A1 (en) * 2021-08-20 2025-05-01 Thomas Jefferson University Monophosphoryl lipid adjuvant (mpla) compositions, vaccine compositions thereof, and methods of preparing and using the same

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WO2020163730A2 (en) 2020-08-13
US12324855B2 (en) 2025-06-10
US20230381108A1 (en) 2023-11-30
MY206596A (en) 2024-12-25
CN113710269A (zh) 2021-11-26
US20200253873A1 (en) 2020-08-13
BR112021014794A2 (pt) 2021-10-05
TWI868106B (zh) 2025-01-01
JP2022520060A (ja) 2022-03-28
PH12021551876A1 (en) 2022-05-23
US20250275920A1 (en) 2025-09-04
SG11202108312PA (en) 2021-08-30
EA202192203A1 (ru) 2021-10-20
IL285163B2 (en) 2025-05-01
AU2020219804A1 (en) 2021-08-19
MX2021009508A (es) 2021-09-08
JOP20210211A1 (ar) 2023-01-30
TW202045204A (zh) 2020-12-16
IL285163B1 (en) 2025-01-01
EP3920966A2 (en) 2021-12-15
IL285163A (en) 2021-09-30
JP2024178161A (ja) 2024-12-24
WO2020163730A3 (en) 2020-09-24
US11684576B2 (en) 2023-06-27
CA3129252A1 (en) 2020-08-13
JP7541527B2 (ja) 2024-08-28

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