KR20210089194A - Liquid crystal emulsion composition and method for preparing same - Google Patents

Abstract

(식중, n은 15∼50, m은 1∼16의 정수, R은 알킬기로 탄소수가 C12∼C24에 의해 선택된다.)　

(식중, n은 15∼50, R은 알킬기로 탄소수가 C12∼C24에 의해 선택된다.)
(B)폴리옥시에틸렌의 부가몰수가 15 이상 60 이하, 알킬기의 탄소수 C15∼C24의 폴리옥시에틸렌 지방산 유도체인 친수성 계면활성제(b1), 폴리옥시에틸렌의 부가몰수가 20 이상 100 이하인 폴리옥시에틸렌 경화 피마자유인 친수성 계면활성제(b2) 중 어느 하나, 또는 양쪽：1 wt% 이상 8 wt% 이하
(C)비친수성 계면활성제：2 wt% 이상 8 wt% 이하
(D)유분：5 wt% 이상 30 wt% 이하
(E)수용성 알코올：15 wt% 이상 80 wt% 이하
(F)트리메틸글리신：1 wt% 이상 8 wt% 이하
(G)물：8 wt% 이상 40 wt% 이하. An object of the present invention is to provide a liquid crystal emulsion composition having a viscous petrolatum phase and low stickiness after application.
In order to solve the above problems, the liquid crystal emulsion composition of the present invention is characterized in that it comprises the following (A) to (G) in the following ratio.
(A) Any one of a hydrophilic surfactant (a1) which is a polyoxyethylene/polyoxypropylene/alkyl ether represented by the following general formula (1), and a hydrophilic surfactant (a2) which is a polyoxyethylene alkyl ether represented by the following general formula (2) , or both: 1 wt% or more and 8 wt% or less

(Wherein, n is 15 to 50, m is an integer of 1 to 16, R is an alkyl group and the number of carbons is selected by C12 to C24.)

(Wherein, n is 15 to 50, R is an alkyl group and the number of carbons is selected by C12 to C24.)
(B) Hydrophilic surfactant (b1) which is a polyoxyethylene fatty acid derivative having an added mole number of polyoxyethylene of 15 or more and 60 or less, an alkyl group having C15 to C24 carbon atoms, Polyoxyethylene curing having an added mole number of polyoxyethylene of 20 or more and 100 or less Any one or both of the hydrophilic surfactant (b2) which is castor oil: 1 wt% or more and 8 wt% or less
(C) Non-hydrophilic surfactant: 2 wt% or more and 8 wt% or less
(D) Oil content: 5 wt% or more and 30 wt% or less
(E) Water-soluble alcohol: 15 wt% or more and 80 wt% or less
(F) Trimethylglycine: 1 wt% or more and 8 wt% or less
(G) Water: 8 wt% or more and 40 wt% or less.

Description

Liquid crystal emulsion composition and method for preparing same

The present invention relates to a liquid crystal emulsion composition.

It is known to use a liquid crystal phase for emulsification. Conventionally, in order to obtain a liquid crystal emulsion composition, since emulsification treatment by applying a strong shear force, such as a homomixer, a high pressure homogenizer, or a microfluidizer, has to be performed, manufacturing is complicated.

The inventors belonging to the present applicant have found that by using a hydrophilic surfactant of a specific molecular structure, mainly polyoxyethylene/polyoxypropylene/alkyl ether, the liquid crystal phase can be changed only by heating the mixture until it becomes uniform (isotropic) and then cooling it. A liquid crystal emulsion composition that is very easy to manufacture has been proposed (Patent Documents 1 and 2).

The liquid crystal emulsion composition described in Patent Documents 1 and 2 has a high viscosity and is excellent in stability in which the liquid crystal structure is not destroyed by dilution. In addition, this liquid crystal emulsion composition is creamy with a sense of transparency, and unlike a general emulsified cream, it has a feeling without "stickiness". However, in the liquid crystal emulsion compositions described in Patent Documents 1 and 2, since the above-described hydrophilic surfactant is solid at room temperature, when the composition contains a large amount of this hydrophilic surfactant, “stickiness (after application)”, which is an important item as a feeling of use, is "There was a problem that it fell.

Japanese Patent Laid-Open No. 2007-169213 Japanese Patent Laid-Open No. 2007-169214

An object of the present invention is to provide a liquid crystal emulsion composition having a viscous petrolatum phase and low stickiness after application.

Means for solving the problems of the present invention are as follows.

1. A liquid crystal emulsion composition comprising the following (A) to (G) in the following ratios.

(A) any one of a hydrophilic surfactant (a1) which is a polyoxyethylene/polyoxypropylene/alkyl ether represented by the following general formula (1), and a hydrophilic surfactant (a2) which is a polyoxyethylene alkyl ether represented by the following general formula (2) , or both: 1 wt% or more and 8 wt% or less

(Wherein, n is 15 to 50, m is an integer of 1 to 16, R is an alkyl group and the number of carbons is selected by C12 to C24.)

(Wherein, n is 15 to 50, R is an alkyl group and the number of carbons is selected by C12 to C24.)

(B) Hydrophilic surfactant (b1) which is a polyoxyethylene fatty acid derivative having an added mole number of polyoxyethylene of 15 or more and 60 or less, an alkyl group having C15 to C24 carbon atoms, Polyoxyethylene curing having an added mole number of polyoxyethylene of 20 or more and 100 or less Any one or both of the hydrophilic surfactant (b2) which is castor oil: 1 wt% or more and 8 wt% or less

(C) Non-hydrophilic surfactant: 2 wt% or more and 8 wt% or less

(D) Oil content: 5 wt% or more and 30 wt% or less

(E) Water-soluble alcohol: 15 wt% or more and 80 wt% or less

(F) Trimethylglycine: 1 wt% or more and 8 wt% or less

(G) Water: 8 wt% or more and 40 wt% or less

2. The liquid crystal emulsion composition according to 1., wherein the sum of (A), (B) and (C) is 5 wt% or more and 14 wt% or less.

3. Based on 100 parts by weight of the surfactant ((A), (B), and (C)) in total, (D) in 1. or 2. characterized in that it contains 100 parts by weight or more and 300 parts by weight or less A liquid crystal emulsion composition as described.

4. (F) The liquid crystal emulsion composition according to any one of 1. to 3., wherein the proportion of trimethylglycine is 1 wt% or more and 5 wt% or less.

5. A process of mixing the following (A) to (D) and heating to 60° C. or higher to make a uniform oily liquid;

A step of mixing the following (E) to (G) to make a uniform aqueous liquid, and the temperature of the aqueous liquid is within the range of ±10° C. with respect to the temperature of the oily liquid;

A step of mixing the oily liquid and the aqueous liquid to make a uniform liquid, followed by cooling

A method for producing a liquid crystal emulsion composition, characterized in that it has a.

(A) any one of a hydrophilic surfactant (a1) which is a polyoxyethylene/polyoxypropylene/alkyl ether represented by the following general formula (1), and a hydrophilic surfactant (a2) which is a polyoxyethylene alkyl ether represented by the following general formula (2) , or both: 1 wt% or more and 8 wt% or less

(Wherein, n is 15 to 50, m is an integer of 1 to 16, R is an alkyl group and the number of carbons is selected by C12 to C24.)

(Wherein, n is 15 to 50, R is an alkyl group and the number of carbons is selected by C12 to C24.)

(B) Hydrophilic surfactant (b1) which is a polyoxyethylene fatty acid derivative having an added mole number of polyoxyethylene of 15 or more and 60 or less, an alkyl group having C15 to C24 carbon atoms, Polyoxyethylene curing having an added mole number of polyoxyethylene of 20 or more and 100 or less Any one or both of the hydrophilic surfactant (b2) which is castor oil: 1 wt% or more and 8 wt% or less

(C) Non-hydrophilic surfactant: 2 wt% or more and 8 wt% or less

(D) Oil content: 5 wt% or more and 30 wt% or less

(E) Water-soluble alcohol: 15 wt% or more and 80 wt% or less

(F) Trimethylglycine: 1 wt% or more and 8 wt% or less

(G) Water: 8 wt% or more and 40 wt% or less

In addition, the compound represented by General formula 1 or 2 is manufactured by the method etc. described in document: Unexamined-Japanese-Patent No. 2011-32398. The number of moles of ethylene oxide or propylene oxide added to the alcohol molecule by this method is not constant, for example, in a2, if it is a compound represented by _{HO(C 2} H ₄ O) _{20 R, HO (C 2} H ₄ O) _It is obtained as a mixture of compounds distributed in a width of about 10 R to HO(C ₂ H ₄ O) _{30 R.}

n represents the average number of added moles thereof. In the case of a surfactant marketed as a cosmetic grade, the average value is not calculated by actually analyzing the distribution by gas chromatography, etc., but as a molar ratio of alcohol and ethylene oxide reacted during production. It is customary to set n. In addition, m represents the average number of added moles thereof. In the case of a surfactant marketed as a cosmetic grade, the average value is not calculated by actually analyzing the distribution by gas chromatography, etc., but rather of alcohol and propylene oxide reacted during production. It is customary to determine m as a molar ratio.

The liquid crystal emulsion composition of the present invention has a small tackiness after application and excellent feeling of use. The liquid crystal emulsion composition of the present invention is in the form of viscous petrolatum, and may be diluted to obtain a creamy formulation. In addition, the liquid crystal emulsion composition of the present invention can maintain the liquid crystal structure even after dilution, and since the generation of emulsified particles due to the destruction of the liquid crystal structure does not occur even after dilution, it can be formulated as a gel with a lower viscosity.

The liquid crystal emulsion composition of the present invention has a lamellar structure (lamellar structure) in which an aqueous phase and an oil phase are alternately and regularly laminated, and has the same structure as the intercellular lipid, so it has high skin affinity and is easy to penetrate. Since the liquid crystal composition of the present invention may contain a hydrophilic active ingredient in the aqueous phase and a lipophilic active ingredient in the oil phase, the active ingredient can effectively penetrate into the stratum corneum by applying the blend of these active ingredients to the skin. In addition, since the liquid crystal composition of the present invention is absorbed in an aqueous phase or an oil phase in which each of these active ingredients may be stably present, the storage stability of the active ingredient is excellent.

The liquid crystal emulsion composition of the present invention does not need to be emulsified by applying a strong shearing force, and the liquid crystal emulsion composition having a lamellar structure can be obtained simply by heating the mixture to make a uniform liquid, and then cooling the mixture. , can be manufactured at low cost.

The liquid crystal emulsion composition of the present invention is characterized in that it contains the following components (A) to (G) in a specific ratio. In this specification, a surfactant having an HLB value of 10 or more is called a “hydrophilic surfactant”, and a surfactant having an HLB value of less than 10 is called a “non-hydrophilic surfactant”.

(A)

The liquid crystal emulsion composition of the present invention comprises any one of a hydrophilic surfactant (a1), a hydrophilic surfactant (a2) (hereinafter, the hydrophilic surfactant (a1) and the hydrophilic surfactant (a2) are combined, and is also referred to as a hydrophilic surfactant A), or 1 wt% or more and 8 wt% or less of both.

(A) is a main component which forms a stable liquid crystal phase with (C) below. In addition, a stable liquid crystal is formed by combining with the (D) oil component, but since the optimal surfactant differs depending on the type of the (D) oil component (especially higher alcohol) to be combined, both polyoxyethylene and polyoxypropylene are mixed with polyoxyethylene and polyoxypropylene. It is necessary to properly combine the hydrophilic surfactant (a1) with polyoxyethylene and the hydrophilic surfactant (a2) with polyoxyethylene.

The hydrophilic surfactant (a1) is a polyoxyethylene/polyoxypropylene/alkyl ether represented by the following general formula (1).

(Wherein, n is 15 to 50, m is an integer of 1 to 16, R is an alkyl group and the number of carbons is selected by C12 to C24.)

As a specific thing of a hydrophilic surfactant (a1), "polyoxyethylene (20), polyoxypropylene (4) cetyl ether (HLB 16.5)", "polyoxyethylene (20), polyoxypropylene (8), cetyl ether" (HLB 12.5)", "polyoxyethylene (20), polyoxypropylene (6), decyltetradecyl ether (HLB 11.0)", "polyoxyethylene (30), polyoxypropylene (6), decyltetradecyl ether" (HLB 12.0)" etc. are mentioned.

The hydrophilic surfactant (a2) is a polyoxyethylene alkyl ether represented by the following general formula (2).

(Wherein, n is 15 to 50, R is an alkyl group and the number of carbons is selected by C12 to C24.)

Specific examples of the hydrophilic surfactant (a2) include "polyoxyethylene (20) cetyl ether (HLB 16.5)", "polyoxyethylene (20) decyl tetradecyl ether (HLB 11.0)", and "polyoxyethylene (30)" behenyl ether (HLB 18.0)" etc. are mentioned.

In (a1) and (a2), all of the carbon atoms of the alkyl group represented by R are C12 to C24. If it is less than 12, the solubility with respect to an oil phase becomes high, it becomes difficult to orientate at an interface, and it becomes difficult to form a stable liquid crystal structure. When it exceeds 24, it becomes larger than the alkyl chain of a higher alcohol normally used in cosmetics, and it becomes difficult to form a stable liquid crystal structure.

In (a1) and (a2), it is 15-50 with respect to the added mole number of polyoxyethylene. If it is less than 15, hydrophilicity is insufficient, and if it exceeds 50, hydrophilicity becomes too high and it becomes difficult to orientate at an interface, and it becomes difficult to form a stable liquid crystal structure.

In addition, in (a1), it is 1-16 about the added mole number of polyoxypropylene. When it exceeds 16, lipophilicity becomes too high and it becomes difficult to orientate at an interface, and it becomes difficult to form a stable liquid crystal structure.

The compounding quantity of (A) is 1 wt% or more and 8 wt% or less in total of (a1) and (a2). If it is less than 1 wt%, a stable liquid crystal structure is not sufficiently formed, and even if it exceeds 8 wt%, the formation of a stable liquid crystal structure is not further promoted, and the viscosity of the composition becomes excessively high and spread to the skin becomes very heavy, usability deteriorates.

(B)

The liquid crystal emulsion composition of the present invention contains any one of a hydrophilic surfactant (b1), a hydrophilic surfactant (b2) (hereinafter, the hydrophilic surfactant (b1) and the hydrophilic surfactant (b2) are combined, also referred to as hydrophilic surfactant B), or 1 wt% or more and 8 wt% or less of both.

(B) is a component that forms a stable liquid crystal in a system containing a highly polar oil component. Since the oily active ingredient blended into the cosmetic is easily soluble in the highly polar oil in many cases, polar oil is often blended for stable blending in the emulsifying formulation. On the other hand, since polar oil has high compatibility with surfactant, it may make it difficult to orientate surfactant to an interface. For this reason, it is necessary to mix|blend suitably (b1) and (b2) which are excellent in the emulsification ability of a polar oil as an ester type hydrophilic surfactant.

The hydrophilic surfactant (b1) is a polyoxyethylene fatty acid derivative having an added mole number of polyoxyethylene of 15 to 60 and an alkyl group having C15 to C24 carbon atoms.

When carbon number of an alkyl group is less than 15, the solubility with respect to an oil phase becomes high, and it becomes impossible to exhibit the emulsification ability with respect to polar oil. When it exceeds 24, the emulsification ability of the polar oil does not further improve, and there is a possibility that it may agglomerate and precipitate over time, which may adversely affect storage stability.

It is 15 or more and 60 or less about the added mole number of polyoxyethylene. When the added mole number of polyoxyethylene is less than 15 or more than 60, it will become difficult to form a liquid crystal especially in presence of polar oil.

Specific examples of the hydrophilic surfactant (b1) include "polyethylene glycol monostearate (55 EO) (HLB 18.0)", "polyoxyethylene (15) glyceryl stearate (HLB 13.5)", "monisostearic acid POE" (20) sorbitan (HLB 15.0)", "polyoxyethylene (40) stearic acid (HLB 16.0)", "polyoxyethylene (20) glyceryl isostearate (HLB 13.0)", etc. are mentioned.

Hydrophilic surfactant (b2) is polyoxyethylene hydrogenated castor oil whose added mole number of polyoxyethylene is 20 or more and 100 or less. When the added mole number of polyoxyethylene is less than 20 or exceeds 100, it will become difficult to form a liquid crystal especially in presence of polar oil.

Moreover, all polyoxyethylene hydrogenated castor oil which is a hydrophilic surfactant (b2) and an added mole number is 20 or more HLB 10 or more.

The blending amount of (B) is 1 wt% or more and 8 wt% or less in total of (b1) and (b2). If it is less than 1 wt%, the stabilizing effect of the highly polar oil is insufficient, and even if it exceeds 8 wt%, the stabilizing effect of the polar oil is not further improved, and the viscosity of the composition becomes excessively high and spreads to the skin is very heavy. usability deteriorates.

The liquid crystal composition of the present invention is characterized in that it contains the following (C) non-hydrophilic surfactant, (D) oil, and (E) water-soluble polyhydric alcohol in a specific ratio. The liquid crystal composition of the present invention is excellent in stability of the lamellar structure of the liquid crystal because a strong layered structure of the aqueous phase/surfactant/oil phase is formed by including these in a specific ratio.

(C)

(C) is a component which forms a stable liquid-crystal structure in the vicinity of an oil-water interface with (A). Because it is non-hydrophilic, it becomes possible to form a stable liquid crystal structure by aligning it with hydrophilic (A) in a balanced manner. As for the blending amount, an appropriate blending amount of 2 wt% or more and 8 wt% or less is selected according to the type of coexisting oil (D). If it is less than 2 wt%, it is an insufficient amount to form a stable liquid crystal structure, and if it exceeds 8 wt%, the lipophilicity of the entire surfactant increases, making it difficult to form a liquid crystal.

Specific examples of the non-hydrophilic surfactant include "polyoxyethylene (5) glycerin monostearate (HLB 9.5)", "glycerin monostearate (HLB 3.0)", and "self-emulsifying glycerin monostearate (HLB 8.0)" and the like.

(D)

As the oil component, solid oil, semi-solid oil, and liquid oil may all be used, but liquid crystal formation is often difficult with only liquid oil, so it is preferable to mix and use the three types as appropriate. In addition, the solid oil and liquid oil are solid and liquid oil at room temperature (25°C), respectively, and the semi-solid oil has a melting point at a temperature exceeding room temperature (25°C) and does not completely solidify at room temperature, so it is a liquid oil. , which is distinct from solid oil.

(1) Examples of the solid oil include cholesteryl stearate, diglyceryl stearate, glyceryl tristearate, chimil stearate, beeswax, straight chain higher alcohol, batyl alcohol, hydroxystearic acid, behenic acid, and the like. .

(2) Examples of the semi-solid oil include petrolatum, stearic acid hydrogenated castor oil, hydrogenated jojoba oil, tri(caprylic acid/capric acid) glycerin, and the like.

The solid oil and the semi-solid oil are preferable in terms of being suitable for imparting a feeling of use required as a cosmetic cream of the composition, that is, a concentration or a sense of adhesion. Moreover, especially a linear higher alcohol among a solid oil is preferable at the point which forms a stable liquid crystal with hydrophilic surfactant A. Examples of the straight-chain higher alcohol that forms a stable liquid crystal include capryl alcohol, lauryl alcohol, myristyl alcohol, cetyl alcohol (cetanol), cetostearyl alcohol, stearyl alcohol, and behenyl alcohol.

(3) As liquid oil, squalane, silicone oil, liquid paraffin, isopropyl myristic acid, jojoba oil, olive oil, macadamia nut oil, synthetic isoparaffin, diisopropyl adipate, glyceryl tri-2-ethylhexanoate , octyldodecyl myristate, isostearyl alcohol, and di(phytosteryl/octyldodecyl) lauroylglutamic acid.

It is preferable to select the liquid oil in consideration of the feeling of use required as a cosmetic cream of the composition and the solubility of the active ingredient to be blended. That is, it is preferable to make up the liquid oil mainly using silicone oil or the like when a feeling of use with light spread and low stickiness is required, and synthetic isoparaffin when a high emollient feeling is required. In addition, when mixing a component with poor solubility, such as a ceramide, in order to improve solubility and suppress precipitation etc. with time, it is preferable to mix|blend a liquid oil component with high polarity.

However, if an oil component is composed of only high polarity oil, the surfactant may be difficult to align at the interface and thus may not form a liquid crystal structure. Therefore, it is preferable to appropriately combine oil with low polarity, specifically, IOB ( It is preferable to combine the thing whose inorganic value/organic value, Inorganic Organic Balance) is 0.1 or less.

As described above, in order to form a stable liquid crystal, to have an excellent feeling of use as a cosmetic such as a cream, and to keep the active ingredient stable, it is preferable to mix and use a solid oil, a semi-solid oil, and a liquid oil in an appropriate combination. Do. Moreover, it is preferable to properly combine the high polarity oil component and the low polarity oil component.

The compounding quantity of (D) is 5 wt% or more and 30 wt% or less. If it is less than 5 wt%, it is difficult to adjust the appropriate viscosity, and when applied to the skin, a sufficient emollient effect cannot be exhibited, and if it exceeds 30 wt%, it is often an oil-in-water type emulsified particle.

(E)

Examples of the water-soluble alcohol (E) used in the present invention include glycerin, diglycerin, polyglycerin, propylene glycol, 1,3-propanediol, tripropylene glycol, dipropylene glycol, butylene glycol, 1,3-butylene glycol, 1,4-butylene glycol, triethylene glycol, polyethylene glycol, sorbitol, xylitol, glucose, maltitol, etc. are mentioned.

The compounding quantity of (E) is 15 wt% or more and 80 wt% or less. If it is less than 15 wt%, it often becomes an ordinary oil-in-water type emulsified particle, and if it exceeds 80 wt%, the surfactant becomes difficult to align at the interface, and liquid crystal is not formed.

(F)

The liquid crystal emulsion composition of the present invention is characterized in that it contains 1 wt% or more and 8 wt% or less of trimethylglycine. Although trimethylglycine has conventionally been widely used as a moisturizing agent, the stickiness of the liquid crystal emulsion composition can be reduced by including trimethylglycine at a specific magnification. When the blending amount of trimethylglycine is less than 1 wt%, the effect of improving stickiness is insufficient. Even if the compounding quantity of trimethylglycine exceeds 8 wt%, the improvement of the stickiness reduction effect is not recognized, and production|generation of a liquid crystal may be inhibited. The blending amount of trimethylglycine is preferably 1 wt% or more and 7 wt% or less, more preferably 1 wt% or more and 6 wt% or less, and still more preferably 1 wt% or more and 5 wt% or less.

The liquid crystal emulsion composition of this invention WHEREIN: It is preferable that the total amount of surfactant (A), (B), and (C) is 5 wt% or more and 14 wt% or less, since it is easy to form a liquid crystal phase. Moreover, it is preferable that (D) oil content is 100 weight part or more and 300 weight part or less with respect to 100 weight part in total of surfactant ((A), (B), (C)). When the amount of this oil content is less than 100 parts by weight, a liquid crystal phase is easily formed, but the obtained composition becomes extremely viscous and difficult to apply to the skin in some cases. Conversely, when this amount of oil content is more than 300 weight part, it may become difficult to form a liquid crystal phase.

「Manufacturing method」

The method for preparing the liquid crystal emulsion composition of the present invention is not particularly limited, but it is preferably prepared by heat treatment. Specifically,

A step of mixing the above (A) to (D) and heating to 60° C. or higher to obtain a uniform oily liquid;

A step of mixing the above (E) to (G) to make a uniform aqueous liquid, and the temperature of the aqueous liquid is within the range of ±10° C. with respect to the temperature of the oily liquid;

A step of mixing the oily liquid and the aqueous liquid prepared above to make a uniform liquid, followed by cooling

A liquid crystal emulsion composition can be manufactured by this.

It is possible to prepare a liquid crystal emulsion composition even if the components (A) to (G) are mixed at once, heated to make a uniform liquid, and then cooled, but when all are mixed at once, it is difficult to visually confirm whether any undissolved residue is generated. . By separately mixing and heating the components forming the oil phase and the aqueous phase of the liquid crystal phase, it can be easily confirmed whether the compounds forming each phase are dissolved to form a uniform liquid.

Although the liquid-crystal emulsion composition of this invention can maintain a liquid-crystal phase even if it dilutes 2 times with water in some cases, presence of the oily liquid substance more than a certain level is required for formation of the liquid-crystal phase in the said manufacturing method. For this reason, in the said method, even if an aqueous liquid is prepared using the amount of water equivalent to 2-fold dilution, a liquid crystal phase may not be formed.

In addition, in the present invention, the formation of the liquid crystal phase can be judged by observation with a polarizing microscope, and in the state where the sample is present in the entire field of view, the state in which the liquid crystal phase is observed in 40% or more of the field of view is said to have been formed. do.

Example

The method of the present invention will be described in detail below by way of examples. In addition, this invention is not limited to this.

The surfactants ((A), (B), (C)) and (D) oil are mixed according to the formulations shown in Tables 1 to 3 (numeric values are % by weight), and dissolved uniformly by heating at 70 to 75°C. and it was set as an oily liquid. (E) water-soluble alcohol, (F) trimethylglycine, and (G) water were mixed, heated to 70-75°C to uniformly dissolve to obtain an aqueous liquid product. Both were mixed and cooled to 40° C. or less.

The obtained liquid crystal emulsion composition itself can be used as a skin care cream, but it is heavy to spread to the skin in the form of petroleum jelly. For this reason, in order to make application to the skin practically easy, it is preferable to dilute and adjust the viscosity and usability to an appropriate level. Accordingly, the obtained composition and the product diluted twice with purified water were evaluated in the following manner for liquid crystal phase formation and usability (stickiness).

"Formation of liquid crystal phase"

A small amount (about 0.01 to 0.02 grams) of the obtained composition is poured on a slide glass, a cover glass is placed, and shear is applied by lightly moving the cover glass, followed by observation with a polarizing microscope (100 to 200 times), and evaluation based on the following criteria (○, △, ×).

○: Liquid crystal is formed in 80% or more of the field of view

(triangle|delta): liquid crystal is formed in 40% or more and less than 80% of a field of view

x: formation of a liquid crystal is less than 40% of a visual field

「Usability (sticky)」

A semantic differential method used for sensory evaluation of cosmetics (a method devised by Mr. Osgood in 1952, Reference: Cosmetics War 11, Section 9) was evaluated by 10 expert panelists for the texture after 10 minutes of applying the obtained composition to the cheek area. Author: Ikeyama Yutaka Co., Ltd. Information Agency, published in 2006).

In other words, for the question of "I'm concerned about stickiness", "I'm concerned" = 1 point, "I'm a little concerned" = 2 points, "I can't say either way" = 3 points, "I'm not very concerned" A rating was given on a five-point scale of "I don't care" = 4 points and "I don't care" = 5 points, and evaluation was made based on the following criteria (○, △, ×).

○: A panel with an average score of 10 or more of 4.0 and a score of 1 or 2

2 or less

△: The average score of 10 people is 3.0 or more but less than 4.0;

or 3 or more panelists with an average GPA of 4.0 or higher and a score of 1 or 2

×: The average GPA of 10 people is less than 3.0

In Comparative Examples 1 and 3 containing no trimethylglycine, liquid crystal emulsion compositions were obtained, but had stickiness. On the other hand, in Comparative Examples 2 and 4 in which 10 wt% of trimethylglycine was blended, stickiness was improved, but a liquid crystal phase was difficult to form. In addition, (C) Comparative Example 5 in which the blending amount of the non-hydrophilic surfactant was small as 1 wt%, (C) the blending amount of the non-hydrophilic surfactant was small as 1 wt% and (B) the blending amount of the hydrophilic surfactant was large as 14 wt% In Comparative Example 6, it became difficult to form a liquid crystal phase.

On the other hand, in Examples 1 to 10 containing 1 to 8 wt% of (F) trimethylglycine, the stickiness was improved. In Examples 1-4, 8-10, even if it diluted, the characteristic before dilution, ie, formation of a liquid crystal, and no stickiness were maintained. On the other hand, in Examples 5-7, when there was much compounding quantity of trimethylglycine, the tendency for a liquid crystal to be destroyed with dilution was confirmed.

The formulation example of the liquid crystal emulsion composition of this invention is given below. In addition, the application example of the liquid crystal emulsion composition of this invention is not limited by the following formulation example.

Prescription example 1　moisturizing cream

After heating to obtain uniform oil-based liquids and aqueous liquids from the formulations shown in Table 4, these were mixed and further cooled to obtain a liquid-crystal emulsion composition. With respect to 50 parts by weight of this liquid crystal emulsion composition, 50 parts by weight of the mixture of the following composition was stirred and mixed at room temperature until uniform, to obtain a moisturizing cream.

Purified water 80.80　 wt%

Glycerin 10.00

1,3-propanediol 6.00

Dipropylene glycol 2.00

citric acid 0.02

Sodium citrate 0.18

Phenoxyethanol 1.00

Prescription Example 2　Moisturizing Essence

After heating to obtain uniform oily liquid and aqueous liquid from the formulations shown in Table 5, these were mixed and further cooled to obtain a liquid crystal emulsion composition. With respect to 25 parts by weight of this liquid crystal emulsion composition, 75 parts by weight of the mixture of the following composition was stirred and mixed at room temperature until uniform, to obtain a moisturizing serum.

Purified water 79.20　 wt%

Glycerin 10.00

1,3-butanediol 8.00

Trehalose 2.00

citric acid 0.02

Sodium citrate 0.18

Phenoxyethanol 0.60

The liquid crystal emulsion composition of the present invention is not limited to the above examples and formulation examples, but within the scope of the present invention and based on the technical idea of the present invention, each disclosure element (including elements described in the claims, specifications and drawings) ) may include various modifications, changes, and improvements. In addition, within the scope of the claims of the present invention, various combinations, substitutions or selections of each disclosed element are possible.

With respect to the numerical range described herein, even if there is no separate description, any numerical value or range included within the range should be construed as specifically described herein.

Claims (5)

A liquid crystal emulsion composition comprising the following (A) to (G) in the following ratio:
(A) Any one of a hydrophilic surfactant (a1) which is a polyoxyethylene/polyoxypropylene/alkyl ether represented by the following general formula (1), and a hydrophilic surfactant (a2) which is a polyoxyethylene alkyl ether represented by the following general formula (2) , or both: 1 wt% or more and 8 wt% or less

(Wherein, n is 15 to 50, m is an integer of 1 to 16, R is an alkyl group and the number of carbons is selected by C12 to C24.)

(Wherein, n is 15 to 50, R is an alkyl group and the number of carbons is selected by C12 to C24.)
(B) Hydrophilic surfactant (b1) which is a polyoxyethylene fatty acid derivative having an added mole number of polyoxyethylene of 15 or more and 60 or less, an alkyl group having C15 to C24 carbon atoms, Polyoxyethylene curing having an added mole number of polyoxyethylene of 20 or more and 100 or less Any one or both of the hydrophilic surfactant (b2) which is castor oil: 1 wt% or more and 8 wt% or less
(C) Non-hydrophilic surfactant: 2 wt% or more and 8 wt% or less
(D) Oil content: 5 wt% or more and 30 wt% or less
(E) Water-soluble alcohol: 15 wt% or more and 80 wt% or less
(F) Trimethylglycine: 1 wt% or more and 8 wt% or less
(G) Water: 8 wt% or more and 40 wt% or less. According to claim 1,
A liquid crystal emulsion composition characterized in that the sum of (A), (B) and (C) is 5 wt% or more and 14 wt% or less. 3. The method of claim 1 or 2,
A liquid crystal emulsion composition comprising 100 parts by weight or more and 300 parts by weight or less of the (D) oil component based on 100 parts by weight of the surfactant ((A), (B), and (C)) in total. 4. The method according to any one of claims 1 to 3,
(F) A liquid crystal emulsion composition characterized in that the proportion of trimethylglycine is 1 wt% or more and 5 wt% or less. A step of mixing the following (A) to (D) and heating to 60° C. or higher to make a uniform oily liquid;
A step of mixing the following (E) to (G) to make a uniform aqueous liquid, and the temperature of the aqueous liquid is within the range of ±10 ° C. with respect to the temperature of the oily liquid;
A step of mixing the oily liquid and the aqueous liquid to make a uniform liquid, followed by cooling
A method for producing a liquid crystal emulsion composition comprising:
(A) Any one of a hydrophilic surfactant (a1) which is a polyoxyethylene/polyoxypropylene/alkyl ether represented by the following general formula (1), and a hydrophilic surfactant (a2) which is a polyoxyethylene alkyl ether represented by the following general formula (2) , or both: 1 wt% or more and 8 wt% or less

(Wherein, n is 15 to 50, m is an integer of 1 to 16, R is an alkyl group and the number of carbons is selected by C12 to C24.)

(Wherein, n is 15 to 50, R is an alkyl group and the number of carbons is selected by C12 to C24.)
(B) Hydrophilic surfactant (b1) which is a polyoxyethylene fatty acid derivative having an added mole number of polyoxyethylene of 15 or more and 60 or less, an alkyl group having C15 to C24 carbon atoms, Polyoxyethylene curing having an added mole number of polyoxyethylene of 20 or more and 100 or less Any one or both of the hydrophilic surfactant (b2) which is castor oil: 1 wt% or more and 8 wt% or less
(C) Non-hydrophilic surfactant: 2 wt% or more and 8 wt% or less
(D) Oil content: 5 wt% or more and 30 wt% or less
(E) Water-soluble alcohol: 15 wt% or more and 80 wt% or less
(F) Trimethylglycine: 1 wt% or more and 8 wt% or less
(G) Water: 8 wt% or more and 40 wt% or less.