WO2013008595A1

WO2013008595A1 - Oil-in-water-type external preparation for skin

Info

Publication number: WO2013008595A1
Application number: PCT/JP2012/065811
Authority: WO
Inventors: 有宇子松浦; 大村　孝之; 光大平
Original assignee: 株式会社資生堂
Priority date: 2011-07-08
Filing date: 2012-06-21
Publication date: 2013-01-17
Also published as: JP2013018724A; CN103648470B; JP5132800B1; CN103648470A; TW201304808A

Abstract

Provided is an oil-in-water-type external preparation for the skin, which contains a high-molecular-weight polyethylene glycol, and has excellent rich texture, excellent long-term stability in a broad environmental temperature range from a lower temperature to a higher temperature and a good sensation upon application. The oil-in-water-type external preparation for the skin is characterized by comprising (a) a high-molecular-weight polyethylene glycol, (b) a higher alcohol, (c) sodium N-stearoyl-N-methyltaurine in an amount of less than 2.0 mass%, and (d) a nonionic surfactant. The high-molecular-weight polyethylene glycol is preferably polyethylene glycol 20000, and the nonionic surfactant (d) is preferably contained in an amount of 1.0 to 10.0 mass% relative to the total amount of the oil-in-water-type external preparation for the skin.

Description

Oil-in-water topical skin preparation

The present invention relates to an oil-in-water type skin external preparation, and more particularly, to an oil-in-water type skin external preparation having excellent aging stability at a wide range of environmental temperatures ranging from low to high while having an excellent richness.

Since the oil-in-water emulsion composition has a fresh and refreshing feeling of use, it is suitably applied to skin cosmetics such as skin care creams. However, in general, an emulsified composition is obtained by compulsorily dispersing an aqueous phase and an oil phase, which are not inherently mixed, with an emulsifier. Detachment).

For example, various electrolytes such as organic acid salts and inorganic acid salts are added for the purpose of imparting effects such as moisturizing, astringency, and keratolysis to the skin, and moisturizing effects are imparted to improve the elongation on the skin. However, it is known that these impair the stability over time of the oil-in-water emulsion composition.

Therefore, a method for stably blending these components into an oil-in-water external skin preparation has been studied. As a typical example, a water-soluble polymer such as xanthan gum is blended to give a structural viscosity to the aqueous phase. The method is known. However, in order to maintain stability under long-term storage, it is necessary to add a large amount of this polymer component, which causes slimming, spreading weight and stickiness during application, and the usability is significantly impaired. End up.

In view of such circumstances, long-chain acyl sulfonate anions are used in gel-like compositions having a viscosity of a predetermined value or more in order to improve stability over time without relying on water-soluble polymers such as xanthan gum. A method of blending an ionic surfactant with a higher alcohol (Patent Documents 1 and 2), a specific polyoxyethylene fatty acid sorbitan, an anionic surfactant and a nonionic surfactant having an IOB value of 1.6 or more, having a specific structure A method of blending higher alcohols in combination at a specific ratio (Patent Document 3) has been proposed.

On the other hand, when applying cosmetics to the skin, high molecular weight polyethylene glycol may be blended in order to give a rich feeling of use, that is, a so-called “richness”. High molecular weight polyethylene glycol is a polymer compound in which the total average number of added moles of ethylene oxide units in the molecule is 220 to 4500. Among them, polyethylene glycol 20000 (PEG 20000) is preferable because of its remarkable effect of richness. It is used for. However, when high molecular weight polyethylene glycol is added to the oil-in-water emulsion composition, the richness is improved, but the stability over time is impaired, and separation may occur. So far, no means for stabilizing an oil-in-water emulsion composition containing a high molecular weight polyethylene glycol has been proposed.

Japanese Patent Laid-Open No. 2005-132808 JP 2008-44866 A JP 2008-88129 A

That is, a new means for stably blending high molecular weight polyethylene glycol into an oil-in-water skin external preparation is still desired.
The present invention contains a high-molecular-weight polyethylene glycol that improves the richness of the product while affecting the stability of the preparation, has excellent temporal stability over a wide range of environmental temperatures, and has good usability. An object is to provide an oil-type external preparation for skin.

As a result of intensive studies to solve the above problems, the present inventor, when producing an oil-in-water external skin preparation containing a high molecular weight polyethylene glycol, a higher alcohol, a nonionic surfactant, , N-stearoyl-N-methyltaurine sodium can be used to obtain an oil-in-water skin external preparation that has sufficient richness, is non-sticky, has a good feeling in use, and has good stability over time. As a result, the present invention has been completed.

Thus, the gist of the present invention is as follows.
(1) water containing (a) high molecular weight polyethylene glycol, (b) higher alcohol, (c) less than 2.0% by weight N-stearoyl-N-methyltaurine sodium, and (d) a nonionic surfactant. Oil-type skin external preparation.
(2) (a) The oil-in-water type skin external preparation of (1) whose high molecular weight polyethylene glycol is polyethylene glycol 20000.
(3) (d) Oil-in-water type skin (1) or (2) containing 1.0 to 10.0% by mass of nonionic surfactant based on the total amount of oil-in-water type external preparation for skin Topical agent.

The oil-in-water type skin external preparation of the present invention contains a higher alcohol, N-stearoyl-N-methyltaurine sodium, and a nonionic surfactant when producing an oil-in-water type skin external preparation containing high molecular weight polyethylene glycol. By blending, it has remarkably excellent temporal stability, and the generation of syneresis can be suppressed. Further, since it is not necessary to add a large amount of a water-soluble polymer such as xanthan gum, there is no deterioration in the feeling of use due to the occurrence of stickiness.
Furthermore, since a sufficient amount of high molecular weight polyethylene glycol can be blended stably, the body feels excellent and a rich feeling in use can be obtained.

For example, Patent Documents 1 and 2 describe that when N-acylmethyltaurine salt and a nonionic surfactant are used in combination, stability at high temperature is not sufficient (paragraph 0005). However, when high molecular weight polyethylene glycol is blended, in addition to higher alcohol, N-acylmethyltaurine salt, especially N-stearoyl-N-methyltaurine sodium and a nonionic surfactant should be used in combination. Thus, it was a surprising finding contrary to the teaching of the prior art that the stability over time can be improved without impairing the richness and the feeling of use.

The oil-in-water type skin external preparation of the present invention comprises (a) high molecular weight polyethylene glycol, (b) higher alcohol, (c) less than 2.0% by mass of N-stearoyl-N-methyltaurine sodium, and (d) non It contains an ionic surfactant. Hereinafter, the present invention will be described in detail.

<(A) High molecular weight polyethylene glycol>
The high molecular weight polyethylene glycol refers to a polyethylene glycol that is semi-solid at room temperature and has an average molecular weight of 10,000 to 25,000, more preferably 15,000 to 25,000. When the average molecular weight is less than 10,000, it is difficult to give a sufficient rich feeling to the oil-in-water skin external preparation, and when it exceeds 25,000, emulsification becomes difficult and the preparation tends to be unstable. The high molecular weight polyethylene glycol is not particularly limited as long as it is acceptable for cosmetics. For example, a product sold under the trade name “PEG-20000” by Sanyo Chemical Industries, Ltd. is preferably exemplified. .

The high molecular weight polyethylene glycol is 5.0% by mass or less, preferably 0.5 to 3.0% by mass, more preferably 1.0 to 3.0% by mass, based on the total amount of the oil-in-water type external skin preparation. It is blended with. When the blending amount is less than 0.5% by mass of the oil-in-water skin external preparation, it becomes difficult to give a sufficient rich feeling to the oil-in-water skin external preparation, and when it exceeds 5.0% by mass, the oil-in-water skin The tendency for the stability with time of external preparations to decrease becomes remarkable.

<(B) Higher alcohol>
The higher alcohol is not particularly limited as long as it can be used in the fields of cosmetics, pharmaceuticals, quasi drugs, and the like, and examples thereof include saturated linear monohydric alcohols and unsaturated monohydric alcohols. As saturated linear monohydric alcohols, dodecanol (= lauryl alcohol), tridecanol, tetradecanol (= myristyl alcohol), pentadecanol, hexadecanol (= cetyl alcohol), heptadecanol, octadecanol (= stearyl) Alcohol), nonadecanol, icosanol (= aralkyl alcohol), heicosanol, docosanol (= behenyl alcohol), tricosanol, tetracosanol (= carnervir alcohol), pentacosanol, hexacosanol (= seryl alcohol) and the like. Examples of unsaturated monohydric alcohols include elaidyl alcohol. In the present invention, a saturated linear monohydric alcohol is preferable from the viewpoint of stability and the like. These can use 1 type (s) or 2 or more types as needed.

The blending amount of the higher alcohol is 10.0% by mass or less, preferably 1.0 to 7.0% by mass, more preferably 2.0 to 6.%, based on the total amount of the oil-in-water type external preparation for skin. 0% by mass. When it is less than 1.0% by mass, there is a tendency that sufficient stability over time cannot be obtained. When the amount exceeds 10.0% by mass, it tends to be heavy when applied to the skin or a sticky feeling tends to occur, which is not preferable.

<(C) Sodium N-stearoyl-N-methyltaurine>
The present invention is characterized in that N-stearoyl-N-methyltaurine sodium represented by the following formula (I) is particularly selected and blended among N-acylmethyltaurine salts in combination with other essential components. Have
R ₁ CO—N (CH ₃ ) — (CH ₂ ) ₂ SO ₃ Na (I)
In the formula (I), the acyl group part (R ₁ CO—) represents a stearoyl group which is a fatty acid residue having 18 carbon atoms.

N-stearoyl-N-methyltaurine sodium is a surfactant conventionally blended in cosmetics including those described in Patent Documents 1 to 3, for example, “NIKKOL SMT” from Nikko Chemicals Corporation. A product sold under the name is preferably exemplified.

N-stearoyl-N-methyltaurine sodium is less than 2.0% by mass, preferably 0.1 to 1.0% by mass, more preferably 0.1 to 0%, based on the total amount of the oil-in-water external skin preparation. 0.5% by mass. When the blending amount is less than 0.1% by mass with respect to the total amount of the oil-in-water skin external preparation, the stability over time of the oil-in-water skin external preparation may not be sufficiently ensured. On the other hand, when it is added in an amount of 2.0% by mass or more, the sticky feeling due to N-stearoyl-N-methyltaurine sodium itself becomes prominent, and the use feeling of the oil-in-water type skin external preparation tends to be lowered.

<(D) Nonionic surfactant>
The nonionic surfactant is usually used in cosmetics, and may be lipophilic or hydrophilic, and one or more kinds may be used as necessary.
The lipophilic nonionic surfactant is not particularly limited. For example, POE (3) oleyl ether, POE (3) lauryl ether, glyceryl monostearate, diglyceryl monostearate, decaglyceryl pentastearate, tristearin Acid hexaglyceryl, POE (2) nonylphenyl ether, glyceryl palmitate, glyceryl isostearate, propylene glycol stearate, PEG (5-7) hydrogenated castor oil, PEG (5-20) glyceryl triisostearate, PEG isostearate (3-8) Glyceryl, PEG tristearate (3-15) glyceryl, PEG trioleate (5-10) glyceryl, PEG triisostearate (10-40) hydrogenated castor oil, PEG isostearate (5-30 Hydrogenated castor oil, POE sorbitol monostearate, POE sorbitol isostearate, POE sorbitol oleate, and the like.

Further, the hydrophilic nonionic surfactant is not particularly limited. For example, POE (10 to 40) glyceryl monoisostearate, hexaglyceryl monolaurate, decaglyceryl monolaurate, decaglyceryl monomyristate, monostearic acid Decaglyceryl, decaglyceryl monooleate, POE (40-60) castor oil, POE (30-100) hydrogenated castor oil, PEG (40-60) glyceryl triisostearate, PEG (10-60) glyceryl isostearate, trio PEG (40-60) glyceryl isostearate PEG (40-60) hydrogenated castor oil, PEG-60 hydrogenated castor oil triisostearic acid, lauric acid PEG (40-60) hydrogenated castor oil, POE (7- 20) Cetyl ether, POE ( 0 to 50) oleyl ether, and the like.

The compounding amount of the nonionic surfactant is 10.0% by mass or less, preferably 1.0 to 7.0% by mass, more preferably 2.10% by mass with respect to the total amount of the oil-in-water external skin preparation. It is 0 to 6.0% by mass. If the amount is less than 1.0% by mass, sufficient stability over time cannot be obtained, and if it exceeds 10.0% by mass, the nonionic surfactant itself becomes sticky. It is not preferable.

<Composition ingredients other than the above>
The oil-in-water type external preparation for skin according to the present invention is an oil-in-water emulsion composition, and it is essential to mix water and oil.

The oil content can be selected from those generally used in cosmetics as long as the stability is not impaired. Desirable oils include hydrocarbon oils, silicone oils, liquid oils, ester oils, and the like.

As the hydrocarbon oil, liquid paraffin, squalane, squalene, paraffin, isoparaffin, ceresin, petrolatum, hydrogenated polydecene and the like can be used.

Examples of the silicone oil include chain silicones such as dimethylpolysiloxane, methylphenylpolysiloxane, and methylhydrogenpolysiloxane; cyclic silicones such as octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, and dodecamethylcyclohexasiloxane; Examples thereof include silicone resin and silicone rubber forming a network structure.

Liquid oils include palm oil, palm kernel oil, flaxseed oil, camellia oil, macadamia nut oil, corn oil, mink oil, olive oil, avocado oil, sasanqua oil, castor oil, safflower oil, jojoba oil, sunflower oil, almond oil Rapeseed oil, sesame oil, soybean oil, peanut oil, triglycerin, glyceryl trioctanoate, glycerin triisopalmitate and the like.

Ester oils include cetyl octanoate, hexyl laurate, isopropyl myristate, octyl palmitate, isocetyl stearate, isopropyl isostearate, octyl isopalmitate, isodecyl oleate, cetyl ethylhexanoate, and glyceryl tri-2-ethylhexanoate. And pentaerythritol tetra-2-ethylhexanoate, 2-ethylhexyl succinate, diethyl sebacate and the like.

Moreover, in the oil-in-water type external preparation for skin according to the present invention, in addition to the above-mentioned essential components, the general components used in the external composition for skin such as cosmetics do not substantially impair the effects of the present invention. Can be blended within a qualitative or quantitative range. Examples of the general components include surfactants other than those described above, thickeners, moisturizers, powders, alcohols, water-soluble polymers, oil-soluble polymers, film-forming agents, resins, ultraviolet absorbers, antiseptics Agent, antibacterial agent, fragrance, salt, antioxidant, pH adjusting agent, chelating agent, refreshing agent, anti-inflammatory agent, skin beautifying agent (whitening agent, cell activator, skin roughness improving agent, blood circulation promoter, skin astringent agent And antiseborrheic agents), vitamins, amino acids, nucleic acids, hormones, inclusion compounds, and the like.

The oil-in-water type external preparation for skin according to the present invention is not particularly limited, but the oil phase component content is preferably about 20% by mass or less. Here, the oil phase component means a component that is mixed as an oil phase and dispersed and emulsified in the water phase when producing an oil-in-water type external skin preparation. Specifically, the oil component In addition, oil-soluble preservatives, oil-soluble ultraviolet absorbers, oil-soluble drugs, oil-based antioxidants, oil-based fragrances and the like are included. When the amount of the oil phase component is more than 20% by mass, it becomes oily in terms of the feeling of use, and stickiness occurs, which is not preferable.

<Method for producing oil-in-water type skin external preparation>
The oil-in-water type external preparation for skin according to the present invention can be produced by a commonly used method for producing an emulsified composition. Specifically, the aqueous phase component and the oil phase component can be separately mixed at the same temperature, and the oil phase can be dispersed and emulsified in the aqueous phase while stirring, and then appropriately cooled.

<Prescription form of oil-in-water type skin external preparation>
The oil-in-water type external preparation for skin according to the present invention can be used for all possible skin cosmetics such as moisturizing creams, skin care cosmetics such as essences, and body care cosmetics such as sunscreens and body creams.

Hereinafter, the present invention will be described in more detail based on examples, but the present invention is not limited to the following examples. In addition, all compounding quantities are represented by the mass% with respect to the total weight of an oil-in-water type skin external preparation.

Prior to the examples, the evaluation methods employed in each example will be described.

[Usability evaluation (bright feeling)]
The sensory evaluation when 0.5 g of the oil-in-water type skin external preparation of each Example and Comparative Example was taken on the palm and spread on the face was performed based on the following criteria.
○: Feels very rich △: Feels rich but feels unsatisfactory ×: Cannot feel rich and lightly begins to stretch

[Stability evaluation over time]
Samples obtained in Examples and Comparative Examples were stored at 0 ° C., room temperature (25 ° C.), and 37 ° C. for 2 weeks, and examined visually for syneresis, based on the following evaluation criteria. And evaluated.
(Evaluation)
○: All samples tested show no detachment Δ: Some samples tested show detachment ×: All samples tested show detachment

(Examples 1 and 2 and Comparative Examples 1 to 7)
An oil-in-water type skin external preparation having the composition shown in Table 1 below was prepared, and this was used as a sample to evaluate usability and stability over time according to the above evaluation criteria. The results are also shown in Table 1.
(Manufacturing method)
The oil phase part ((7) to (18)) and the water phase part ((1) to (6) and (19) to (21)) are completely dissolved at 70 ° C., respectively. The resulting mixture was stirred and emulsified at 70 ° C., and then the emulsion particle size was adjusted at 65 ° C. using a homomixer, and cooled to room temperature to obtain a cream.

As is clear from the results shown in Table 1, an oil-in-water skin external preparation containing all of high molecular weight polyethylene glycol, higher alcohol, N-stearoyl-N-methyltaurine sodium, and a nonionic surfactant (Example 1) Showed excellent results in both the richness and the stability over time at a wide range of environmental temperatures ranging from low to high. This result was the same even when no xanthan gum as a thickening stabilizer was blended at all (Example 2).
On the other hand, when N-stearoyl-N-methyltaurine sodium is not included compared to Example 1 (Comparative Example 1), the nonionic surfactant is changed instead of not containing N-stearoyl-N-methyltaurine sodium. In the case of Comparative Example 2 to 4 and the case of containing N-stearoyl-N-methyltaurine sodium but not containing the nonionic surfactant (Comparative Example 5) It was confirmed that the stability was poor.
Moreover, a sufficient rich feeling cannot be obtained unless polyethylene glycol 20000 is blended in an oil-in-water type skin external preparation (Comparative Example 6), and blending of xanthan gum, which is a thickening stabilizer even if blended with polyethylene glycol 20000 When the amount was too large, stickiness became remarkable, and it was confirmed again that the usability was impaired (Comparative Example 7).

(Example 3 and Comparative Examples 8 to 10)
An oil-in-water type external preparation for skin having the composition shown in Table 2 below was prepared in the same manner as described above, and this was used as a sample to evaluate usability and stability over time according to the above evaluation criteria. The results are also shown in Table 2.

As is apparent from the results shown in Table 2, instead of N-stearoyl-N-methyltaurine sodium, palmitoylmethyl taurine sodium having a similar structure to this (Comparative Example 8), cocoyl methyl taurine sodium (Comparative Example 9) It was confirmed that sufficient stability over time could not be obtained even when the same amount of sodium taurate methyl taurate (Comparative Example 10) was blended.

(Examples 4 to 5 and Comparative Example 11)
An oil-in-water type skin external preparation having the composition shown in Table 3 below was prepared by the same method as described above, and using this as a sample, usability and stability over time were evaluated according to the above evaluation criteria. The results are also shown in Table 3.

As is apparent from the results shown in Table 3, if the amount of sodium N-stearoyl-N-methyltaurine is too large, stickiness of N-stearoyl-N-methyltaurine sodium may occur and the usability may be impaired. confirmed.

(Example 6: Skin care cream)
Compounding ingredients Mass%
(1) Ion exchange water Residual (2) Glycerin 6.0
(3) Dipropylene glycol 5.0
(4) 1,3-butylene glycol 8.0
(5) Polyethylene glycol 20000 2.0
(6) Xanthan gum 0.01
(7) PEG-60 glyceryl isostearate 2.0
(8) Lipophilic glyceryl monostearate 2.0
(9) N-stearoyl-N-methyltaurine sodium 0.3
(10) Stearyl alcohol 1.5
(11) Behenyl alcohol 2.2
(12) Vaseline 1.0
(13) Hardened oil (hydrogenated palm oil, palm kernel oil) 2.5
(14) Cetyl ethylhexanoate 3.0
(15) Hydrogenated polybutene 3.0
(16) Phenoxyethanol appropriate amount (17) citric acid appropriate amount (18) sodium citrate appropriate amount (19) edetic acid · 2Na appropriate amount

Production method:
The oil phase part ((7) to (16)) and the water phase part ((1) to (6) and (17) to (19)) are completely dissolved at 70 ° C., respectively. The resulting mixture was stirred and emulsified at 70 ° C., and then the emulsion particle size was adjusted at 65 ° C. using a homomixer, and cooled to room temperature to obtain a cream.
When this cream was evaluated by the same method as described above, it was confirmed that there was a sufficient richness when applied to the skin and that the stability over time was also excellent.

(Example 7: Cream containing agar microcapsules)
Compounding ingredients Mass%
(1) Ion exchange water Residual (2) Glycerin 6.0
(3) Dipropylene glycol 5.0
(4) 1,3-butylene glycol 8.0
(5) Polyethylene glycol 20000 2.0
(6) Xanthan gum 0.01
(7) Agar 0.05
(8) PEG-60 glyceryl isostearate 2.0
(9) Lipophilic glyceryl monostearate 2.0
(10) Polyoxyethylene / methylpolysiloxane copolymer 0.02
(11) N-stearoyl-N-methyltaurine sodium 0.3
(12) Stearyl alcohol 1.5
(13) Behenyl alcohol 2.2
(14) Vaseline 1.0
(15) Hardened oil (hydrogenated palm oil, palm kernel oil) 2.5
(16) Cetyl ethylhexanoate 3.0
(17) Hydrogenated polybutene 3.0
(18) Methylpolysiloxane 1.0
(19) Royal jelly extract 0.01
(20) Phenoxyethanol appropriate amount (21) citric acid appropriate amount (22) sodium citrate appropriate amount (23) edetic acid · 2Na appropriate amount

Production method:
The oil phase part ((8) to (20)) and the water phase part ((1) to (6) and (21) to (23)) are completely dissolved at 70 ° C., respectively. And agitated and emulsified at 70 ° C., separately prepared agar microcapsule parts (7) were added and emulsified at 70 ° C., and then the emulsion particle size was adjusted using a homomixer at 65 ° C. Adjustments were made and cooled to room temperature to obtain a cream.
When this cream was evaluated by the same method as described above, it was confirmed that there was a sufficient richness when applied to the skin and that the stability over time was also excellent.

(Example 8: Skin care cream without thickener)
Compounding ingredients Mass%
(1) Ion exchange water Residual (2) Glycerin 6.0
(3) Dipropylene glycol 5.0
(4) 1,3-butylene glycol 8.0
(5) Polyethylene glycol 20000 2.0
(6) PEG-60 glyceryl isostearate 2.0
(7) Lipophilic glyceryl monostearate 2.0
(8) N-stearoyl-N-methyltaurine sodium 0.3
(9) Stearyl alcohol 1.5
(10) Behenyl alcohol 2.2
(11) Vaseline 1.0
(12) Hardened oil (hydrogenated palm oil, palm kernel oil) 2.5
(13) Cetyl ethylhexanoate 3.0
(14) Hydrogenated polybutene 3.0
(15) Phenoxyethanol appropriate amount (16) citric acid appropriate amount (17) sodium citrate appropriate amount (18) edetic acid · 2Na appropriate amount

Production method:
The oil phase part ((6) to (15)) and the water phase part ((1) to (5) and (16) to (18)) are completely dissolved at 70 ° C., respectively. The resulting mixture was stirred and emulsified at 70 ° C., and then the emulsion particle size was adjusted at 65 ° C. using a homomixer, and cooled to room temperature to obtain a cream.
When this cream was evaluated by the same method as described above, it was confirmed that there was a sufficient richness when applied to the skin and that the stability over time was also excellent.

Claims

Oil-in-water skin comprising (a) high molecular weight polyethylene glycol, (b) higher alcohol, (c) less than 2.0% by weight N-stearoyl-N-methyltaurine sodium, and (d) a nonionic surfactant Topical agent.
(A) The oil-in-water type skin external preparation of Claim 1 whose high molecular weight polyethyleneglycol is polyethyleneglycol 20000.
3. The oil-in-water skin external preparation according to claim 1 or 2, wherein the nonionic surfactant is contained in an amount of 1.0 to 10.0% by mass based on the total amount of the oil-in-water skin external preparation. .