JPWO2020138000A1 - Liquid crystal emulsified composition and its manufacturing method - Google Patents

Abstract

It is an object of the present invention to provide a liquid crystal emulsified composition which is viscous petrolatum-like and has little stickiness after application. As a solution, there is provided a liquid crystal emulsified composition containing the following (A) to (G) in the following proportions. (A) A hydrophilic surfactant (a1) which is a polyoxyethylene / polyoxypropylene / alkyl ether represented by the following general formula 1, and a hydrophilic surfactant which is a polyoxyethylene alkyl ether represented by the following general formula 2. Either or both of the activators (a2): 1 wt% or more and 8 wt% or less General formula 1: HO (C2H4O) n- (C3H6O) mR (in the formula, n is an integer of 15 to 50 and m is an integer of 1 to 16. R is an alkyl group and has a carbon number of C12 to C24.) General formula 2: HO (C2H4O) nR (in the formula, n is 15 to 50, R is an alkyl group and has a carbon number of C12 to C24.) (B) The number of added moles of polyoxyethylene is 15 or more and 60 or less, the number of added moles of the hydrophilic surfactant (b1), which is a polyoxyethylene fatty acid derivative having an alkyl group having C15 to C24, and the number of added moles of polyoxyethylene. Either or both of hydrophilic surfactants (b2) which are polyoxyethylene hydrogenated castor oils of 20 or more and 100 or less: 1 wt% or more and 8 wt% or less (C) Non-hydrophilic surfactants: 2 wt% or more and 8 wt% (D) Oil content: 5 wt% or more and 30 wt% or less (E) Water-soluble alcohol: 15 wt% or more and 80 wt% or less (F) Trimethylglycine: 1 wt% or more and 8 wt% or less (G) Water: 8 wt% or more and 40 wt% or less.

Description

The present invention relates to a liquid crystal emulsified composition.

It is known that the liquid crystal phase is used for emulsification. Conventionally, in order to obtain a liquid crystal emulsified composition, an emulsification treatment by applying a strong shearing force such as a homomixer, a high-pressure homogenizer, or a microfluidizer must be performed, and the production is complicated.
The inventors belonging to the present applicant have used a hydrophilic surfactant having a specific molecular structure mainly composed of polyoxyethylene, polyoxypropylene, and alkyl ether until the mixture becomes uniform (isotropic). We have proposed a liquid crystal emulsifying composition that becomes a liquid crystal phase only by heating and then cooling, which is very easy to produce (Patent Documents 1 and 2).

The liquid crystal emulsified composition described in Patent Documents 1 and 2 has a high viscosity and is excellent in stability so that the liquid crystal structure is not destroyed by dilution. Further, this liquid crystal emulsified composition is in the form of a transparent cream, and unlike a general emulsified cream, has a non-sticky feel. However, in the liquid crystal emulsified compositions described in Patent Documents 1 and 2, since the above-mentioned hydrophilic surfactant is solid at room temperature, it is important as a feeling of use when the composition contains a large amount of this hydrophilic surfactant. There was a problem that it was inferior to the item "stickiness (after application)".

JP-A-2007-169213 JP-A-2007-169214

An object of the present invention is to provide a liquid crystal emulsified composition which is viscous petrolatum and has less stickiness after application.

The means for solving the problem of the present invention is as follows.
1. 1. A liquid crystal emulsified composition comprising the following (A) to (G) in the following proportions.
(A) A hydrophilic surfactant (a1) which is a polyoxyethylene / polyoxypropylene / alkyl ether represented by the following general formula 1, and a hydrophilic interface which is a polyoxyethylene alkyl ether represented by the following general formula 2. Either or both of the activators (a2): 1 wt% or more and 8 wt% or less General formula 1: HO (C ₂ H ₄ O) n- (C ₃ H ₆ O) mR
(In the formula, n is an integer of 15 to 50, m is an integer of 1 to 16, R is an alkyl group, and the number of carbon atoms is selected by C12 to C24.)
General formula 2: HO (C ₂ H ₄ O) nR
(In the formula, n is selected according to 15 to 50, R is an alkyl group, and the number of carbon atoms is C12 to C24.)
(B) The number of added moles of polyoxyethylene is 15 or more and 60 or less, the number of added moles of the hydrophilic surfactant (b1), which is a polyoxyethylene fatty acid derivative of the alkyl group having C15 to C24, and the number of added moles of polyoxyethylene is 20. Either or both of the hydrophilic surfactants (b2), which are polyoxyethylene hydrogenated castor oils of 100 or more and 100 or less: 1 wt% or more and 8 wt% or less (C) Non-hydrophilic surfactants: 2 wt% or more and 8 wt% or less (D) Oil content: 5 wt% or more and 30 wt% or less (E) Water-soluble alcohol: 15 wt% or more and 80 wt% or less (F) Polyethylene glycol: 1 wt% or more and 8 wt% or less (G) Water: 8 wt% or more and 40 wt% or less 2. 1. The total of (A), (B) and (C) is 5 wt% or more and 14 wt% or less. The liquid crystal emulsified composition according to.
3. 3. 1. The surfactant ((A), (B), (C)) contains 100 parts by weight or more and 300 parts by weight or less of the oil (D) with respect to a total of 100 parts by weight. Or 2. The liquid crystal emulsified composition according to.
4. (F) The ratio of trimethylglycine is 1 wt% or more and 5 wt% or less. ~ 3. The liquid crystal emulsification composition according to any one of.
5. A step of mixing the following (A) to (D) and heating to 60 ° C. or higher to obtain a uniform oily liquid.
A step of mixing the following (E) to (G) to obtain a uniform aqueous liquid, and setting the temperature of the aqueous liquid within the range of ± 10 ° C. with respect to the temperature of the oily liquid.
A step of mixing the oily liquid material and the aqueous liquid material to obtain a uniform liquid material, and then cooling the liquid material.
A method for producing a liquid crystal emulsified composition.
(A) A hydrophilic surfactant (a1) which is a polyoxyethylene / polyoxypropylene / alkyl ether represented by the following general formula 1, and a hydrophilic interface which is a polyoxyethylene alkyl ether represented by the following general formula 2. Either or both of the activators (a2): 1 wt% or more and 8 wt% or less General formula 1: HO (C ₂ H ₄ O) n- (C ₃ H ₆ O) mR
(In the formula, n is an integer of 15 to 50, m is an integer of 1 to 16, R is an alkyl group, and the number of carbon atoms is selected by C12 to C24.)
General formula 2: HO (C ₂ H ₄ O) nR
(In the formula, n is selected according to 15 to 50, R is an alkyl group, and the number of carbon atoms is C12 to C24.)
(B) The number of added moles of polyoxyethylene is 15 or more and 60 or less, the number of added moles of the hydrophilic surfactant (b1), which is a polyoxyethylene fatty acid derivative of the alkyl group having C15 to C24, and the number of added moles of polyoxyethylene is 20. Either or both of the hydrophilic surfactants (b2), which are polyoxyethylene hydrogenated castor oils of 100 or more and 100 or less: 1 wt% or more and 8 wt% or less (C) Non-hydrophilic surfactants: 2 wt% or more and 8 wt% or less (D) Oil content: 5 wt% or more and 30 wt% or less (E) Water-soluble alcohol: 15 wt% or more and 80 wt% or less (F) Polyethylene glycol: 1 wt% or more and 8 wt% or less (G) Water: 8 wt% or more and 40 wt% or less

The compounds represented by the general formulas 1 and 2 are produced by the method described in Document: Japanese Patent Application Laid-Open No. 2011-323298. Molar number of addition of ethylene oxide or propylene oxide added to the alcohol molecule by this method is not constant, for example, a2 with _{HO (C 2 H 4 O)} 20 as long as it is a compound which is denoted as R HO _(C 2 _{H 4} O) It is obtained as a mixture of compounds distributed in a range of about ₁₀ R to HO (C ₂ H ₄ O) _{30 R.}
n indicates the average number of added moles, but with a surfactant commercially available as a cosmetic grade, the distribution is not actually analyzed by gas chromatography or the like to calculate the average value, but is manufactured. It is customary to determine n by the molar ratio of alcohol to ethylene oxide that is sometimes reacted. Further, m indicates the average number of moles added, but with a surfactant commercially available as a cosmetic grade, the distribution is not actually analyzed by gas chromatography or the like to calculate the average value. It is customary to determine m by the molar ratio of alcohol and propylene oxide to be reacted during production.

The liquid crystal emulsified composition of the present invention has little stickiness after application and is excellent in usability. The liquid crystal emulsified composition of the present invention is in the form of viscous petrolatum and can be diluted into a creamy dosage form. Further, the liquid crystal emulsified composition of the present invention can maintain the liquid crystal structure even after dilution, and since emulsified particles are not generated due to destruction of the liquid crystal structure even after dilution, a gel-like dosage form having a lower viscosity is formed. Can be.

The liquid crystal emulsifying composition of the present invention has a lamellar structure (layered structure) in which an aqueous phase and an oil phase are alternately and regularly laminated, and has a structure similar to that of intercellular lipids, so that it is easily adapted to the skin. And it is easy to penetrate. Since the liquid crystal composition of the present invention can contain a hydrophilic active ingredient in the aqueous phase and a lipophilic active ingredient in the oil phase, it is possible to apply a mixture of these active ingredients to the skin. The active ingredient can be effectively penetrated into the stratum corneum. Further, the liquid crystal composition of the present invention is excellent in storage stability of the active ingredient because it is incorporated into an aqueous phase or an oil phase in which these active ingredients can be stably present.

The liquid crystal emulsifying composition of the present invention does not need to be emulsified by applying a strong shearing force, and is a liquid crystal emulsifying composition having a lamellar structure only by heating the mixture to form a uniform liquid and then cooling. Therefore, it can be manufactured very easily and at low cost.

The liquid crystal emulsified composition of the present invention is characterized by containing the following components (A) to (G) in a specific ratio. In the present specification, a surfactant having an HLB value of 10 or more is referred to as a "hydrophilic surfactant", and a surfactant having an HLB value of less than 10 is referred to as a "non-hydrophilic surfactant".

(A)
In the liquid crystal emulsifying composition of the present invention, a hydrophilic surfactant (a1) and a hydrophilic surfactant (a2) (hereinafter, a hydrophilic surfactant (a1) and a hydrophilic surfactant (a2) are combined. Either or both of (also referred to as hydrophilic surfactant A) is contained in an amount of 1 wt% or more and 8 wt% or less.
(A) is a main component that forms a stable liquid crystal phase with the following (C). Furthermore, a stable liquid crystal is formed by combining with (D) oil, but since the optimum surfactant differs depending on the type of (D) oil (particularly higher alcohol) to be combined, polyoxyethylene and polyoxypropylene It is necessary to appropriately combine the hydrophilic surfactant (a1) having both and the hydrophilic surfactant (a2) having polyoxyethylene.

The hydrophilic surfactant (a1) is a polyoxyethylene / polyoxypropylene / alkyl ether represented by the following general formula 1.
General formula 1: HO (C ₂ H ₄ O) n- (C ₃ H ₆ O) mR
(In the formula, n is an integer of 15 to 50, m is an integer of 1 to 16, R is an alkyl group, and the number of carbon atoms is selected by C12 to C24.)
Specific examples of the hydrophilic surfactant (a1) include "polyoxyethylene (20) / polyoxypropylene (4) cetyl ether (HLB16.5)" and "polyoxyethylene (20) / polyoxypropylene". (8) ・ Cetyl ether (HLB12.5) ”,“ Polyoxyethylene (20) ・ Polyoxypropylene (6) ・ Decyltetradecyl ether (HLB11.0) ”,“ Polyoxyethylene (30) ・ Polyoxypropylene (6) ・ Decyltetradecyl ether (HLB12.0) ”and the like.

The hydrophilic surfactant (a2) is a polyoxyethylene alkyl ether represented by the following general formula 2.
General formula 2: HO (C ₂ H ₄ O) nR
(In the formula, n is selected according to 15 to 50, R is an alkyl group, and the number of carbon atoms is C12 to C24.)
Specific examples of the hydrophilic surfactant (a2) include "polyoxyethylene (20) cetyl ether (HLB16.5)", "polyoxyethylene (20) decyltetradecyl ether (HLB11.0)", and the like. Examples thereof include "polyoxyethylene (30) behenyl ether (HLB18.0)".

In (a1) and (a2), the number of carbon atoms of the alkyl group represented by R is C12 to C24. If it is less than 12, the solubility in the oil phase is increased, and it is difficult to be oriented at the interface and it is difficult to form a stable liquid crystal structure. If it exceeds 24, it becomes larger than the alkyl chain of a higher alcohol usually used in cosmetics, and it becomes difficult to form a stable liquid crystal structure.
In (a1) and (a2), the number of moles of polyoxyethylene added is 15 to 50. If it is less than 15, the hydrophilicity is insufficient, and if it exceeds 50, the hydrophilicity becomes too high and it is difficult to be oriented at the interface and it is difficult to form a stable liquid crystal structure.
Further, in (a1), the number of moles of polyoxypropylene added is 1 to 16. If it exceeds 16, the lipophilicity becomes too high and it becomes difficult to orient the interface, and it becomes difficult to form a stable liquid crystal structure.

The blending amount of (A) is 1 wt% or more and 8 wt% or less in total of (a1) and (a2). If it is less than 1 wt%, a stable liquid crystal structure is not sufficiently formed, and if it exceeds 8 wt%, the formation of a stable liquid crystal structure is not further promoted, and the viscosity of the composition becomes too high to spread on the skin. Becomes very heavy and the usability deteriorates.

(B)
The liquid crystal emulsifying composition of the present invention comprises a hydrophilic surfactant (b1), a hydrophilic surfactant (b2) (hereinafter, a hydrophilic surfactant (b1), and a hydrophilic surfactant (b2)). Either or both of (also referred to as hydrophilic surfactant B) is contained in an amount of 1 wt% or more and 8 wt% or less.
(B) is a component that forms a stable liquid crystal display in a system containing highly polar oil. Since the oily active ingredient contained in cosmetics is often easily dissolved in highly polar oils, polar oils are often added for stable formulation in emulsified preparations. On the other hand, polar oil has high compatibility with the surfactant, so that it may be difficult to orient the surfactant at the interface. Therefore, it is necessary to appropriately combine (b1) and (b2), which are ester-based hydrophilic surfactants and have excellent emulsifying ability of polar oils.

The hydrophilic surfactant (b1) is a polyoxyethylene fatty acid derivative having an addition molar number of 15 or more and 60 or less and an alkyl group having C15 to C24 carbon atoms.
If the number of carbon atoms of the alkyl group is less than 15, the solubility in the oil phase is increased, and the emulsifying ability for polar oil cannot be exhibited. If it exceeds 24, the emulsifying ability of the polar oil will not be further improved, and it may aggregate and precipitate over time, which may adversely affect the storage stability.
The number of moles of polyoxyethylene added is 15 or more and 60 or less. When the number of moles of polyoxyethylene added is less than 15 or more than 60, it becomes difficult to form a liquid crystal display particularly in the presence of polar oil.
Specific examples of the hydrophilic surfactant (b1) include "polyethylene glycol monostearate (55E.0.) (HLB18.0)" and "polyoxyethylene (15) glyceryl stearate (HLB13.5)". , "POE (20) sorbitan monoisostearate (HLB15.0)", "polyoxyethylene (40) stearic acid (HLB16.0)", "polyoxyethylene (20) glyceryl isostearate (HLB13.0)", etc. Can be mentioned.

The hydrophilic surfactant (b2) is a polyoxyethylene hydrogenated castor oil having a polyoxyethylene addition molar number of 20 or more and 100 or less. When the number of moles of polyoxyethylene added is less than 20 or more than 100, it becomes difficult to form a liquid crystal display particularly in the presence of polar oil.
The polyoxyethylene hydrogenated castor oil having an addition molar number of 20 or more, which is a hydrophilic surfactant (b2), has an HLB of 10 or more.

The blending amount of (B) is 1 wt% or more and 8 wt% or less in total of (b1) and (b2). If it is less than 1 wt%, the stabilizing effect of highly polar oil is insufficient, and if it exceeds 8 wt%, the stabilizing effect of polar oil is not further improved, and the viscosity of the composition becomes too high for the skin. The spread becomes very heavy and the usability deteriorates.

The liquid crystal composition of the present invention is characterized by containing the following (C) non-hydrophilic surfactant, (D) oil, and (E) water-soluble polyhydric alcohol in a specific ratio. The liquid crystal composition of the present invention is excellent in the stability of the lamellar structure of the liquid crystal because a strong layered structure of the aqueous phase / surfactant / oil phase is formed by containing these in a specific ratio.

(C)
(C) is a component that forms a stable liquid crystal structure in the vicinity of the oil-water interface together with (A). Since it is non-hydrophilic, it is possible to form a stable liquid crystal structure by orienting it in a well-balanced manner with the hydrophilic (A). As for the blending amount, an appropriate blending amount of 2 wt% or more and 8 wt% or less is selected depending on the type of coexisting (D) oil. If it is less than 2 wt%, it is insufficient to form a stable liquid crystal structure, and if it exceeds 8 wt%, the lipophilicity of the entire surfactant is increased and it becomes difficult to form a liquid crystal.
Specific examples of the non-hydrophilic surfactant include "polyoxyethylene monostearate (5) glycerin (HLB9.5)", "glycerin monostearate (HLB3.0)", and "self-emulsifying glycerin monostearate". (HLB8.0) ”and the like.

(D)
As the oil content, any of solid oil content, semi-solid oil content, and liquid oil content can be used, but there are many cases where it is difficult to form a liquid crystal only with the liquid oil content, and it is preferable to use a combination of three types appropriately. The solid oil content and the liquid oil content are solid and liquid oil components at room temperature (25 ° C.), respectively, and the semi-solid oil content has a melting point at a temperature exceeding room temperature (25 ° C.) and is completely solidified at room temperature. It is an oil that is distinguished from liquid oil and solid oil.

(1) Examples of the solid oil content include cholesteryl stearate, diglyceryl stearate, glyceryl tristearate, chimil stearate, beeswax, linear higher alcohol, batyl alcohol, hydroxystearic acid, behenic acid and the like.
(2) Examples of the semi-solid oil include petrolatum, stearic acid-hardened castor oil, hydrogenated jojoba oil, and tri (caprylic acid / capric acid) glycerin.
The solid oil content and the semi-solid oil content are preferable because they are suitable for imparting a feeling of use required as a cosmetic cream of the composition, that is, a richness and a feeling of adhesion. Of the solid oils, the linear higher alcohol is particularly preferable because it forms a stable liquid crystal with the hydrophilic surfactant A. Examples of the linear higher alcohol that forms a stable liquid crystal include capryl alcohol, lauryl alcohol, myristyl alcohol, cetyl alcohol (cetyl alcohol), cetostearyl alcohol, stearyl alcohol, and behenyl alcohol.

(3) Liquid oils include squalane, silicone oil, liquid paraffin, isopropyl myristate, jojoba oil, olive oil, macadamia nut oil, synthetic isoparaffin, diisoprovyl adipate, glyceryl tri2-ethylhexanoate, octidodecyl myristate, and isostearyl. Examples thereof include di (phytosteryl / octyldodecyl) lauroyl glutamate such as alcohol.
The liquid oil content is preferably selected in consideration of the feeling of use required for the cosmetic cream of the composition and the solubility of the active ingredient to be blended. That is, it is preferable to form a liquid oil mainly containing silicone oil or the like when a feeling of use with light spread and less stickiness is required, and synthetic isoparaffin or the like when a high emollient feeling is required. Further, when a component having poor solubility such as ceramide is blended, it is preferable to blend a highly polar liquid oil component in order to improve the solubility and suppress precipitation with time.

However, if the oil is composed only of the oil having a high polarity, it may be difficult for the surfactant to be oriented at the interface and it may be difficult to form a liquid crystal structure. Therefore, it is preferable to appropriately combine the oil having a low polarity. , IOB (Inorganic / Organic Value, Organic Polar Interface) of 0.1 or less is preferably combined.
As described above, solid oil, semi-solid oil, and liquid oil are appropriately used in order to form a stable liquid crystal display, have an excellent feeling of use as a cosmetic such as cream, and maintain the active ingredient stably. It is preferable to use them in combination. Further, it is preferable to appropriately combine the oil having a high polarity and the oil having a low polarity.
The blending amount of (D) is 5 wt% or more and 30 wt% or less. If it is less than 5 wt%, it is difficult to adjust the viscosity to an appropriate level, and when it is applied to the skin, a sufficient emollient effect cannot be exhibited. If it exceeds 30 wt%, it often becomes normal oil-in-water emulsified particles.

(E)
Examples of the water-soluble alcohol (E) used in the present invention include glycerin, diglycerin, polyglycerin, propylene glycol, 1,3-propanediol, tripropylene glycol, dipropylene glycol, butylene glycol, 1,3-butylene glycol, 1 , 4-butylene glycol, triethylene glycol, polyethylene glycol, sorbitol, xylitol, glucose, martitol and the like.
The blending amount of (E) is 15 wt% or more and 80 wt% or less. If it is less than 15 wt%, it often becomes normal oil-in-water emulsified particles, and if it exceeds 80 wt%, it becomes difficult for the surfactant to be oriented at the interface and a liquid crystal is not formed.

(F)
The liquid crystal emulsified composition of the present invention is characterized by containing trimethylglycine in an amount of 1 wt% or more and 8 wt% or less. Trimethylglycine has been widely used as a moisturizer, but by containing trimethylglycine in a specific ratio, the stickiness of the liquid crystal emulsified composition can be reduced. If the amount of trimethylglycine blended is less than 1 wt%, the effect of improving stickiness is insufficient. Even if the blending amount of trimethylglycine exceeds 8 wt%, the effect of reducing stickiness is not improved, and the formation of liquid crystal display may be inhibited. The blending amount of trimethylglycine is preferably 1 wt% or more and 7 wt% or less, more preferably 1 wt% or more and 6 wt% or less, and further preferably 1 wt% or more and 5 wt% or less.

In the liquid crystal emulsifying composition of the present invention, the total amount of the surfactants (A), (B) and (C) is preferably 5 wt% or more and 14 wt% or less because it is easy to form a liquid crystal phase. Further, it is preferable that the oil content of (D) is 100 parts by weight or more and 300 parts by weight or less with respect to 100 parts by weight of the total of the surfactants ((A), (B) and (C)). When the amount of oil is less than 100 parts by weight, a liquid crystal phase is easily formed, but the obtained composition becomes extremely viscous and may not be applied to the skin. On the contrary, when the amount of oil is more than 300 parts by weight, it may be difficult to form a liquid crystal phase.

"Production method"
The method for producing the liquid crystal emulsified composition of the present invention is not particularly limited, but it is preferably produced by heat treatment. In particular,
A step of mixing the above (A) to (D) and heating to 60 ° C. or higher to obtain a uniform oily liquid.
A step of mixing the above (E) to (G) to obtain a uniform aqueous liquid, and setting the temperature of the aqueous liquid within the range of ± 10 ° C. with respect to the temperature of the oily liquid.
A step of mixing the oily liquid material and the aqueous liquid material prepared above to obtain a uniform liquid material, and then cooling the liquid material.
Therefore, a liquid crystal emulsified composition can be produced.

A liquid crystal emulsified composition can be produced by mixing the components (A) to (G) at once to obtain a uniform liquid and then cooling, but if all of the components are mixed at once, the undissolved residue remains. It is difficult to visually confirm whether or not there is a problem. By separately mixing and heating the components forming the oil phase and the aqueous phase of the liquid crystal phase, it can be easily confirmed whether the compounds forming each phase are dissolved to form a uniform liquid substance.

The liquid crystal emulsified composition of the present invention may be able to maintain the liquid crystal phase even when diluted 2-fold with water, but the presence of an oily liquid substance to some extent or more is present in the formation of the liquid crystal phase in the above production method. is necessary. Therefore, in the above method, even if an aqueous liquid substance is prepared using an amount of water corresponding to 2-fold dilution, a liquid crystal phase may not be formed.
In the present invention, the formation of the liquid crystal phase can be determined by observing with a polarizing microscope, and when the sample is present in the entire field of view, the liquid crystal phase is observed in 40% or more of the field of view. Suppose a phase is formed.

Hereinafter, the method of the present invention will be described in more detail with reference to Examples. The present invention is not limited to this.
Surfactants ((A), (B), (C)) and oil (D) are mixed according to the formulations shown in Tables 1 to 3 (numerical values are% by weight), and heated to 70 to 75 ° C. to be uniform. It was dissolved in and made into an oily liquid. (E) Water-soluble alcohol, (F) trimethylglycine and (G) water were mixed and heated to 70 to 75 ° C. to uniformly dissolve them into an aqueous liquid substance. Both were mixed and cooled to 40 ° C. or lower.
The obtained liquid crystal emulsified composition can be used as a skin care cream as it is, but it is petrolatum-like and spreads heavily on the skin. Therefore, it is desirable to dilute it to adjust it to an appropriate viscosity and usability so that it can be practically applied to the skin. Therefore, the obtained composition and the one diluted 2-fold with purified water were evaluated for liquid crystal phase formation and usability (stickiness) by the following method.

"Formation of liquid crystal phase"
A small amount (about 0.01 to 0.02 g) of the obtained composition is hung on a slide glass, a cover glass is placed on the slide glass, the cover glass is lightly moved to apply shear, and then the composition is observed with a polarizing microscope (100). ~ 200 times), and evaluated (○, △, ×) based on the following criteria.
◯: Liquid crystal is formed in 80% or more of the visual field Δ: Liquid crystal is formed in 40% or more and less than 80% of the visual field ×: Liquid crystal is formed in less than 40% of the visual field

"Usability (stickiness)"
A semantic differential method (method devised by Mr. Osgood in 1952, a reference: Cosmetics Encyclopedia 11: 9 Author: Yutaka Ikeyama Information Organization Co., Ltd., published in 2006).
That is, in response to the question "Do you care about stickiness?", "Worry" = 1 point, "Slightly worrisome" = 2 points, "I can't say either" = 3 points, "I don't care much" Scores were given on a scale of 4 points, and "don't care" = 5 points, and evaluated (○, △, ×) based on the following criteria.
◯: The average score of 10 people is 4.0 points or more, and the panel with 1 or 2 points is 2 people or less. Δ: The average score of 10 people is 3.0 points or more and less than 4.0.
Or, if the average score is 4.0 points or more and the panel with 1 or 2 points is 3,
Name or more ×: Average score of 10 people is less than 3.0 points

In Comparative Examples 1 and 3 containing no trimethylglycine, a liquid crystal emulsified composition was obtained, but it was sticky. On the other hand, in Comparative Examples 2 and 4 in which 10 wt% of trimethylglycine was blended, the stickiness was improved, but the liquid crystal phase was less likely to be formed. Further, Comparative Example 5 in which (C) the blending amount of the non-hydrophilic surfactant is as small as 1 wt%, (C) the blending amount of the non-hydrophilic surfactant is as small as 1 wt%, and (B) blending of the hydrophilic surfactant. In Comparative Example 6 in which the amount was as large as 14 wt%, the liquid crystal phase was less likely to be formed.
On the other hand, in Examples 1 to 10 in which 1 to 8 wt% of (F) trimethylglycine was blended, the stickiness was improved. In Examples 1 to 4 and 8 to 10, even when diluted, the characteristics before dilution, that is, the formation of liquid crystal display and non-stickiness were maintained. On the other hand, in Examples 5 to 7, when the amount of trimethylglycine blended was large, the liquid crystal tended to be destroyed with dilution.

Examples of formulations of the liquid crystal emulsified composition of the present invention are listed below. The application examples of the liquid crystal emulsified composition of the present invention are not limited to the following formulation examples.

Prescription example 1 Moisturizing cream

From the formulations shown in Table 4 above, a uniform oily liquid and aqueous liquid were obtained by heating, and then these were mixed and further cooled to obtain a liquid crystal emulsified composition. A moisturizing cream was obtained by stirring and mixing 50 parts by weight of the mixture having the following composition with respect to 50 parts by weight of the liquid crystal emulsified composition until it became uniform at room temperature.
Purified water 80.80 wt%
Glycerin 10.00
1,3-Propanediol 6.00
Dipropylene glycol 2.00
Citric acid 0.02
Sodium citrate 0.18
Phenoxyethanol 1.00

Prescription example 2 Moisturizing serum

From the formulations shown in Table 5 above, a uniform oily liquid and aqueous liquid were obtained by heating, and then these were mixed and further cooled to obtain a liquid crystal emulsified composition. A moisturizing beauty essence was obtained by stirring and mixing 75 parts by weight of the mixture having the following composition with respect to 25 parts by weight of the liquid crystal emulsified composition until it became uniform at room temperature.
Purified water 79.20 wt%
Glycerin 10.00
1,3-Butanediol 8.00
Trehalose 2.00
Citric acid 0.02
Sodium citrate 0.18
Phenoxyethanol 0.60

The liquid crystal emulsified composition of the present invention is not limited to the above-mentioned Examples and Formulation Examples, but is within the scope of the present invention and based on the technical idea of the present invention. And various modifications, modifications and improvements to (including the elements described in the drawings). Further, within the scope of the claims of the present invention, various combinations, substitutions or selections of each disclosed element are possible.

The numerical range described in this document should be construed as any numerical value or range contained within the range specifically described in this document, even if otherwise stated.

Claims (5)

A liquid crystal emulsified composition comprising the following (A) to (G) in the following proportions:
(A) A hydrophilic surfactant (a1) which is a polyoxyethylene / polyoxypropylene / alkyl ether represented by the following general formula 1, and a hydrophilic interface which is a polyoxyethylene alkyl ether represented by the following general formula 2. Either or both of the activators (a2): 1 wt% or more and 8 wt% or less General formula 1: HO (C ₂ H ₄ O) n- (C ₃ H ₆ O) mR
(In the formula, n is an integer of 15 to 50, m is an integer of 1 to 16, R is an alkyl group, and the number of carbon atoms is selected by C12 to C24.)
General formula 2: HO (C ₂ H ₄ O) nR
(In the formula, n is selected according to 15 to 50, R is an alkyl group, and the number of carbon atoms is C12 to C24.)
(B) The number of added moles of polyoxyethylene is 15 or more and 60 or less, the number of added moles of the hydrophilic surfactant (b1), which is a polyoxyethylene fatty acid derivative of the alkyl group having C15 to C24, and the number of added moles of polyoxyethylene is 20. Either or both of the hydrophilic surfactants (b2), which are polyoxyethylene hydrogenated castor oils of 100 or more and 100 or less: 1 wt% or more and 8 wt% or less (C) Non-hydrophilic surfactants: 2 wt% or more and 8 wt% or less (D) Oil content: 5 wt% or more and 30 wt% or less (E) Water-soluble alcohol: 15 wt% or more and 80 wt% or less (F) Polyethylene glycine: 1 wt% or more and 8 wt% or less (G) Water: 8 wt% or more and 40 wt% or less. The liquid crystal emulsified composition according to claim 1, wherein the total of (A), (B), and (C) is 5 wt% or more and 14 wt% or less. According to claim 1 or 2, the surfactant ((A), (B), (C)) contains 100 parts by weight or more and 300 parts by weight or less of the oil (D) with respect to a total of 100 parts by weight. The liquid crystal emulsified composition according to the above. (F) The liquid crystal emulsified composition according to any one of claims 1 to 3, wherein the proportion of trimethylglycine is 1 wt% or more and 5 wt% or less. A step of mixing the following (A) to (D) and heating to 60 ° C. or higher to obtain a uniform oily liquid.
A step of mixing the following (E) to (G) to obtain a uniform aqueous liquid, and setting the temperature of the aqueous liquid within the range of ± 10 ° C. with respect to the temperature of the oily liquid.
A step of mixing the oily liquid material and the aqueous liquid material to obtain a uniform liquid material, and then cooling the liquid material.
A method for producing a liquid crystal emulsified composition, which comprises:
(A) A hydrophilic surfactant (a1) which is a polyoxyethylene / polyoxypropylene / alkyl ether represented by the following general formula 1, and a hydrophilic interface which is a polyoxyethylene alkyl ether represented by the following general formula 2. Either or both of the activators (a2): 1 wt% or more and 8 wt% or less General formula 1: HO (C ₂ H ₄ O) n- (C ₃ H ₆ O) mR
(In the formula, n is an integer of 15 to 50, m is an integer of 1 to 16, R is an alkyl group, and the number of carbon atoms is selected by C12 to C24.)
General formula 2: HO (C ₂ H ₄ O) nR
(In the formula, n is selected according to 15 to 50, R is an alkyl group, and the number of carbon atoms is C12 to C24.)
(B) The number of added moles of polyoxyethylene is 15 or more and 60 or less, the number of added moles of the hydrophilic surfactant (b1), which is a polyoxyethylene fatty acid derivative of the alkyl group having C15 to C24, and the number of added moles of polyoxyethylene is 20. Either or both of the hydrophilic surfactants (b2), which are polyoxyethylene hydrogenated castor oils of 100 or more and 100 or less: 1 wt% or more and 8 wt% or less (C) Non-hydrophilic surfactants: 2 wt% or more and 8 wt% or less (D) Oil content: 5 wt% or more and 30 wt% or less (E) Water-soluble alcohol: 15 wt% or more and 80 wt% or less (F) Trimethylglycine: 1 wt% or more and 8 wt% or less (G) Water: 8 wt% or more and 40 wt% or less.