KR20210040408A - 조작된 글리코실트랜스퍼라제 및 스테비올 글리코시드 글루코실화 방법 - Google Patents
조작된 글리코실트랜스퍼라제 및 스테비올 글리코시드 글루코실화 방법 Download PDFInfo
- Publication number
- KR20210040408A KR20210040408A KR1020217006167A KR20217006167A KR20210040408A KR 20210040408 A KR20210040408 A KR 20210040408A KR 1020217006167 A KR1020217006167 A KR 1020217006167A KR 20217006167 A KR20217006167 A KR 20217006167A KR 20210040408 A KR20210040408 A KR 20210040408A
- Authority
- KR
- South Korea
- Prior art keywords
- engineered
- glycosyltransferase
- seq
- positions
- numbered
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/256—Polyterpene radicals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
- C12N9/1062—Sucrose synthase (2.4.1.13)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y204/00—Glycosyltransferases (2.4)
- C12Y204/01—Hexosyltransferases (2.4.1)
- C12Y204/01013—Sucrose synthase (2.4.1.13)
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862712199P | 2018-07-30 | 2018-07-30 | |
US62/712,199 | 2018-07-30 | ||
US201862712327P | 2018-07-31 | 2018-07-31 | |
US62/712,327 | 2018-07-31 | ||
PCT/US2019/042151 WO2020028039A1 (fr) | 2018-07-30 | 2019-07-17 | Glycosyltransférases modifiées et procédés de glucosylation de glycosides de stéviol |
Publications (1)
Publication Number | Publication Date |
---|---|
KR20210040408A true KR20210040408A (ko) | 2021-04-13 |
Family
ID=69178045
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020217006167A KR20210040408A (ko) | 2018-07-30 | 2019-07-17 | 조작된 글리코실트랜스퍼라제 및 스테비올 글리코시드 글루코실화 방법 |
Country Status (13)
Country | Link |
---|---|
US (2) | US11760981B2 (fr) |
EP (1) | EP3830106A4 (fr) |
JP (3) | JP2021532757A (fr) |
KR (1) | KR20210040408A (fr) |
CN (1) | CN112805295A (fr) |
AU (1) | AU2019314181A1 (fr) |
BR (1) | BR112021001661A8 (fr) |
CA (1) | CA3108268A1 (fr) |
IL (1) | IL280302A (fr) |
MX (1) | MX2021001260A (fr) |
SG (1) | SG11202100470WA (fr) |
TW (1) | TW202019951A (fr) |
WO (1) | WO2020028039A1 (fr) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR102331018B1 (ko) | 2016-08-12 | 2021-11-26 | 아미리스 인코퍼레이티드 | 레바우디오시드의 고효율 생산을 위한 udp 의존성 글리코실트랜스퍼라제 |
CN111621482B (zh) * | 2020-06-30 | 2022-04-29 | 浙江工业大学 | 一种草铵膦脱氢酶突变体、基因工程菌及一锅法多酶同步定向进化方法 |
WO2022002918A1 (fr) | 2020-07-03 | 2022-01-06 | C-Lecta Gmbh | Processus de glycosylation acellulaire monotope |
CN112760302B (zh) * | 2020-12-23 | 2022-08-26 | 中化健康产业发展有限公司 | 一种能够催化莱鲍迪苷A生成莱鲍迪苷D的糖基转移酶StUGT |
CN115418358B (zh) * | 2021-06-01 | 2024-01-30 | 弈柯莱生物科技(集团)股份有限公司 | 一种糖基转移酶及其应用 |
WO2022253282A1 (fr) * | 2021-06-01 | 2022-12-08 | 弈柯莱生物科技(上海)股份有限公司 | Glycosyltransférase et son application |
CN115449514B (zh) * | 2021-06-08 | 2023-09-29 | 弈柯莱生物科技(上海)股份有限公司 | 一种β-1,2-糖基转移酶及其应用 |
CN113462670B (zh) * | 2021-08-23 | 2023-03-24 | 兴化格林生物制品有限公司 | 一种糖基转移酶突变体及其催化合成莱鲍迪苷m的方法 |
CN115725528B (zh) * | 2021-08-30 | 2024-01-12 | 弈柯莱生物科技(集团)股份有限公司 | 一种糖基转移酶及其应用 |
CN116555210A (zh) * | 2022-01-30 | 2023-08-08 | 弈柯莱生物科技(上海)股份有限公司 | 糖基转移酶及其在制备莱鲍迪苷e中的应用 |
WO2023226978A1 (fr) * | 2022-05-23 | 2023-11-30 | 苏州引航生物科技有限公司 | Saccharose synthase d'origine microbienne et son utilisation |
WO2024050533A2 (fr) * | 2022-09-02 | 2024-03-07 | Arzeda Corp. | Compositions et procédés de production de rébaudioside m |
WO2024121721A1 (fr) | 2022-12-05 | 2024-06-13 | Tate & Lyle Solutions Usa Llc | Procédés d'obtention de glycosides de stéviol |
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2019
- 2019-07-17 US US16/514,578 patent/US11760981B2/en active Active
- 2019-07-17 SG SG11202100470WA patent/SG11202100470WA/en unknown
- 2019-07-17 BR BR112021001661A patent/BR112021001661A8/pt unknown
- 2019-07-17 CN CN201980064505.5A patent/CN112805295A/zh active Pending
- 2019-07-17 WO PCT/US2019/042151 patent/WO2020028039A1/fr active Application Filing
- 2019-07-17 KR KR1020217006167A patent/KR20210040408A/ko unknown
- 2019-07-17 CA CA3108268A patent/CA3108268A1/fr active Pending
- 2019-07-17 EP EP19843463.1A patent/EP3830106A4/fr active Pending
- 2019-07-17 JP JP2021504769A patent/JP2021532757A/ja not_active Revoked
- 2019-07-17 AU AU2019314181A patent/AU2019314181A1/en active Pending
- 2019-07-17 MX MX2021001260A patent/MX2021001260A/es unknown
- 2019-07-18 TW TW108125485A patent/TW202019951A/zh unknown
-
2021
- 2021-01-20 IL IL280302A patent/IL280302A/en unknown
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2022
- 2022-07-15 JP JP2022113739A patent/JP2022132485A/ja active Pending
- 2022-07-15 JP JP2022113740A patent/JP2023039908A/ja active Pending
-
2023
- 2023-08-02 US US18/364,419 patent/US20240010999A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2021532757A (ja) | 2021-12-02 |
CA3108268A1 (fr) | 2020-02-06 |
IL280302A (en) | 2021-03-01 |
AU2019314181A1 (en) | 2021-02-04 |
US11760981B2 (en) | 2023-09-19 |
TW202019951A (zh) | 2020-06-01 |
MX2021001260A (es) | 2021-04-12 |
US20200032227A1 (en) | 2020-01-30 |
BR112021001661A2 (pt) | 2021-05-04 |
EP3830106A4 (fr) | 2022-07-06 |
BR112021001661A8 (pt) | 2022-08-09 |
US20240010999A1 (en) | 2024-01-11 |
WO2020028039A1 (fr) | 2020-02-06 |
EP3830106A1 (fr) | 2021-06-09 |
JP2023039908A (ja) | 2023-03-22 |
SG11202100470WA (en) | 2021-02-25 |
JP2022132485A (ja) | 2022-09-08 |
CN112805295A (zh) | 2021-05-14 |
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