KR20210003590A - Natural cosmetics for preventing acne - Google Patents

Abstract

The present invention relates to cosmetics containing natural products which are effective against acne. In the treatment area of acne, various drugs have been developed and used, but a healing effect is insignificant with frequent recurrence and there is no preventive concept at all. In addition, the reality is that no study has been conducted to develop cosmetics for acne-prone skin care, and there is no product with a healing concept. Accordingly, the present invention is to develop cosmetics capable of preventing and healing acne, and to provide a cosmetic product which is effective in preventing and healing acne by applying Angelica dahurica, Coptis japonica, Scutellaria baicalensis, licorice or burdock among natural products.

Description

Cosmetics containing natural products for preventing acne{Natural cosmetics for preventing acne}

The present invention relates to cosmetics containing natural substances that are effective against acne. More specifically, it relates to a cosmetic that is effective in treating and preventing acne by containing at least one natural product selected from white paper, yellow lotus, licorice, gold and burdock.

Acne refers to a chronic, refractory, inflammatory skin disease that occurs in hair follicles and sebaceous glands. The causes of such acne are largely increased sebum secretion, stricture due to hyperkeratosis of hair follicles, and proliferation of acne bacteria. It can be explained according to the degree of development of acne symptoms such as, inflammatory reaction, etc. Also, various mechanisms can work in combination.

That is, estrogen, a sex hormone that is increased after puberty, can excessively increase the secretion of sebum and cause stricture of hair follicles. In addition, since the lipid composition of sebum is different from the skin epidermis, it is well oxidized and is also used as an energy source for acne bacteria, so the increase in sebum is thought to be the first factor that can cause acne.

In addition, acne bacteria are anaerobic bacteria that do not proliferate when the hair follicle is open. In other words, when sebum increases and hyperkeratinization of the hair follicle proceeds, the entrance to the hair follicle is blocked, so that comedones, which are the initial lesions of acne, are generated, and excessive proliferation of acne bacteria occurs.

Increased acne bacteria metabolize lipids in sebum to produce various fatty acids that serve as stimulants, and acne bacteria are recognized as antigens, stimulating the body's immune response, resulting in inflammatory reactions. This causes papules and inflammatory acne lesions, and when it worsens, the hair follicle wall is destroyed, and it develops into lesions such as cysts and pustules that damage tissue.

In the area of acne treatment, various medicines have been developed and used, but the selection of cosmetics for proper skin care has not been studied yet.

In the cosmetic field, it is a concept that heals acne by removing hair follicle stenosis through skin peeling, mainly with soap, medicinal soap, and an abrasive cleanser. In addition, the skin peeling and sterilizing effect of acne bacteria by the alcohol component of Astrigent are also effective against acne to some extent. There are also cosmetics containing resorcinol, sulfur, salicylic acid, and benzoyl peroxide. However, since these ingredients are irritating to the skin, there are many side effects and limitations, such as limiting the concentration used.

In addition, antibiotics such as erythromycine for removing acne bacteria, anti-inflamation raw materials for inflammation treatment, and hormone preparations for sebum control are used, but these are mainly raw materials in the pharmaceutical field.

Until now, products have been developed focusing on only one of the aforementioned various mechanisms of occurrence of acne, so the healing effect is insignificant, recurrence is frequent, and there is no preventive concept. In addition, there is no product with a healing concept in the cosmetic field.

Therefore, the inventors of the present inventors have conducted extensive research in order to develop cosmetics that can cure as well as preventing acne, and as a result of finding that among natural products, white paper, yellow lotus, gold, licorice, burdock, etc. are effective in the healing and prevention of acne. The invention was completed.

That is, an object of the present invention is to provide a cosmetic product effective in preventing and healing acne containing white paper, yellow lotus, gold, licorice or burdock.

As described above, it can be seen that the cosmetic according to the present invention is effective in treating and preventing acne by containing white paper, gold, yellow lotus, licorice, or burdock.

Cosmetics effective against acne according to the present invention for achieving the above object is characterized in that it contains at least one selected from the group consisting of white paper, yellow lotus, gold, burdock and licorice among natural substances.

The cosmetic product according to the present invention is prescribed so as not to cause skin irritation or to cause inflammation by removing all lipids that may be similar to the lipid component of sebum. In addition, in order to suppress excessive sebum, natural substances such as sebum control substances such as yellow lotus, burdock, gold extract, licorice with excellent antibacterial activity against acne bacteria, and white paper which are anti-inflammatory substances are mixed to respond to all mechanisms of action that cause acne. It consists of raw material composition.

Natural products used in cosmetics for acne according to the present invention are as follows.

1) blank paper

Scientific name: Angelica daurica

Plant: It is a perennial plant with a height of 1-15m. In summer, small white flowers gather at the long end. The fruit is a small oval and white paper is a name for the root. Roots are used by digging the roots of young plants that do not have a flower stalk in the fall, peeling the outer shell, and drying in the sun.

Ingredients: The root (white paper) contains about 03-09% of coumarin components such as imperatorin, felopterin, and xantroxine, and the essential oil content is more than 02%. It also contains components such as peladrene, hydrocarotene, and oxypentadezilic acid.

Action: White paper has pain relief and sedation. It is known to be due to the purocoumarin component. In addition, it was found to have anticancer activity in animal experiments.

Application: It is used for sedation, pain-stopping medication, blood-stopping medication, colds, and head pain in motion therapy. It is also used as a pain medication after childbirth and is also used for rheumatism and spinal nerve myositis.

2) burdock

Scientific name: Arctium Lappa

Plant: It is a perennial plant with a height of 1-2m. Broad or long egg-shaped leaves attach alternately, and purple red flowers gather at the ends of branches and bloom in summer like the ear of the back. Fruits are harvested in autumn, dried in the sun, and shaken. The roots are harvested in the fall, washed with water and dried before use.

Ingredients: Fruits contain lignan glycosides arcutiin, oil 25-30%, phytosterine, vitamin B1, saponin, coumarin, lemon acid, malic acid, etc., in the roots inulin 27-45%, protein 12%, essential oil 017%, It contains arctein, caffeic acid, tannins and alkaloids.

Action: The fruit has a diuretic action, anti-inflammatory action, and drainage action. In addition, the water extract of the fruit has an antibacterial action against filamentous bacteria that cause skin diseases. The root has a diuretic effect and a metabolism promoting effect. In addition, the alkaloid component has anticancer activity.

Application: In the treatment of copper, fruit is used for inflammatory drugs, fever-lowering drugs, colds, festering wounds, skin diseases, and malignant tumors. Also, the root is used for gastritis and gastric duodenal ulcer.

3) yellow lotus

Scientific name: Coptidis Rhizoma

Plants: Rhizome of Coptis japonica, which has almost removed the roots, contains more than 35% of berberine when measured.

It is uneven conical, 2-4cm, the outer surface is grayish brown, and the stem and the bottom of many roots can be seen.

Ingredients: Berberine is the main ingredient, and in addition, it contains palmatin. It also contains 3 to 7% of alkaloids in trace amounts.

Action: Water extract has anti-inflammatory properties and prevents arteriosclerosis. Water extract has anti-inflammatory properties and prevents arteriosclerosis, while water extract promotes lipase and lowers pepsine. In addition, 50% ethanol extract has antimicrobial activity against Staphylococcus aureus, red and cholera bacteria, and 35% ethanol extract has antispasmodic action on the extracted small intestine.

Application: In oriental medicine, it is used as a raw material for gastrointestinal medicine and adipose medicine.

4) licorice

Scientific name: Glycyrrhiza glabra

Plants: The main stem is attached to the stem, shoots, and leaves, has a peculiar smell, and tastes sweet. Use both skinned and peeled ones.

Ingredients: Triterpene glycoside, glabric acid, flavonones, isoflavones, and other substances are contained, and glycosides are in the main body and non-glycosides are mainly contained in the skin.

Action: The main ingredient, glycyrrhizin or genin, activates estrogen and has anti-inflammatory, detoxifying, and anti-allergic effects. In addition, the fraction containing a large amount of flavonoids has anti-ulcer and antispasmodic effects.

Application: In oriental medicine, it is widely used for cramps and muscle pains for the purpose of pain relief and detoxification.

5) golden

Scientific name: Scutellaria baicalensis

Plant: refers to the roots of the rotted grass peeled off, and the rotted grass is yellowish brown with vertical wrinkles, the quality is hard, but soft and has a weak smell, and the taste is slightly bitter.

Ingredients: Flavonoids, baicalin, chrysin and other free amino acids are the main components.

Action: It is prescribed for diseases accompanying anti-inflammatory, fever and abdominal pain.

In order to find out the efficacy of the natural product for acne, the following test was performed.

[Test Example 1: Anti-chemotactic effect of acne bacteria by natural product sample]

1 Experiment method

end. Separation of leukocytes from neutrophils: After separating the leukocyte layer and the red blood cell layer by the Ficoll-paque method, polymorphic nuclear leukocytes were separated with a 3% dextran solution.

I. Chemotactic test and its inhibitory effect

1) Experimental principle: neutrophil leukocytes are moved by P acnes to induce inflammatory action. At this time, the movement of leukocytes is made by chemotaxis. When natural products, erythromycin and tretinoin are applied to acne bacteria, they exhibit anti-inflammatory action by inhibiting chemotaxis.

2) Experimental method: The chemotaxis induced by 1% P acnes solution was tested for inhibition using natural products and erythromycin, a positive control material.

3) Evaluation method: Using the 48-well micro chemotaxis method, the number of neutrophil leukocytes moved by the chemotaxis of acne bacteria was observed in the field of view of 400 times the optical microscope to determine whether chemotaxis was induced and the inhibitory effect. Compared and judged.

2 Experiment results

The chemotactic test induced with 1% P acnes solution and the results of the test for its inhibitory effect are shown in Table 1.

As shown in Table 1, it can be seen that the application of white paper, licorice, yellow lotus, and burdock had the effect of suppressing the white paper, licorice, yellow lotus, and burdock acne bacteria as the number of neutrophil leukocytes moved was relatively small.

[Test Example 2: Confirmation of antibacterial activity against acne bacteria (P acnes)]

The antibacterial activity test against P acnes was performed by diluting the liquid medium.

Each sample was diluted in 2 ml of liquid BHI medium at 100 ppm intervals from 0 to 1000 ppm, and then 20 μ1 of 10 6 /ml of bacterial solution was inoculated and cultured for 48 hours. The minimum concentration at which growth was inhibited based on turbidity was defined as the lowest growth inhibition concentration (MIC).

P acnes ATCC 6919 and ATCC 11827 were used as strains. The results are shown in Table 2.

As shown in Table 2, it can be seen that gold, yellow lotus, and licorice are particularly excellent in antibacterial activity against acne bacteria.

[Test Example 3 Lipogenesis Inhibition Test]

This is a method of assessing the degree of inhibition of lipid synthesis by quantifying the degree of uptake of carbon elements necessary for lipid synthesis.In order to evaluate the degree of inhibition of lipid synthesis in the sebaceous glands, a hamster ear tissue with many sebaceous glands was biopsied. Incubated in the labeled medium for 6 hours, and the degree of inhibition was evaluated by comparing and quantifying the control group and the sample group with a radioactivity meter. As a sample group, 001% of the sample solution was added to the medium using the hamster's right ear tissue, and 001% of physiological saline was added to the medium using the left ear tissue of the hamster as a control group. The results are shown in Table 3. In Table 3, the inhibition rate was calculated by Equation 1 below, and the value is an average value performed on four hamsters.

Equation 1

As shown in Table 3, it can be seen that yellow lotus, white paper, burdock, and licorice have an inhibitory effect on lipid synthesis. In other words, by inhibiting lipid synthesis, sebum is reduced and the occurrence of acne can be suppressed.

[Test Example 4: Human skin primary stimulation test]

From the results of Test Example 1-3, it can be seen that white paper, yellow lotus, gold, burdock, and licorice are effective in treating and preventing acne, and to determine whether the natural products are harmful to the human body when applied to cosmetics. Human skin irritation test was conducted.

The primary stimulation test for human skin was a human patch test. That is, 30 healthy women aged 20 to 30 years old were conducted according to CTFA guidelines (The Cosmetic, Toiletry and Fragrance Association Inc Washington, DC, 20036, 1991). After dropping 20 µl of the prepared test substance (10% in patch base) in the Finn Chamber, it was washed with 70% ethanol, dried, and then placed on the back, which was the test site, and fixed with micropore tape. . The patch is applied for 24 hours, and after removing the patch, the test site is marked with a marking pen, and after 30 minutes and 24 hours, the skin reaction of each test site is observed, and the International Contact Dermatitis Research Group ; ICDRG). The results are shown in Table 4.

In Table 4, the average reactivity was calculated according to Equation 2 below, where ± was 1 point, + was 2 points, ++ was 3 points, and +++ was 4 points. Criteria for the judgment were grade Ⅰ (non-irritating range) of less than 1, grade Ⅱ (mild stimulation range) of less than 3, grade Ⅲ (medium stimulation range) of less than 5, and grade iv (strong stimulation range) of 5 or more. .

Equation 2

As shown in Table 4, Acne Base showed a stimulus value within a safe range, but the stimulus was rather high. All ingredients exhibited grade II or higher irritation in the test formulation. However, because of the pigmentation problem, Coptis was found to exhibit the same stimulus and relatively high stimulus even though the experiment was conducted at a low concentration. In the case of prescriptions combining various ingredients, all were at the level of the safety range, Grade II (irritation level less than 3).

[Example 1-25]

After manufacturing cosmetics containing natural products in the composition of Tables 5 and 6 below, sebum amount change, efficacy evaluation, and side effect evaluation were performed for each of the manufactured cosmetics, and the results are shown in Table 7.

Evaluation of sebum volume change: Using a sebumeter, the results were compared before the sample treatment and one month after treatment, and the change in sebum volume was evaluated through the reduced ratio.

Efficacy evaluation: Before the sample treatment, the number of acne in a certain area and area of the subject's face was counted, and the number of acne was counted again after one month of treatment. For example, 50% of effectiveness means that 50% of all subjects had a decrease in the number of acne by 20% or more.

Side effect evaluation: The presence or absence of side effects such as irritation through a questionnaire survey of the subject and the evaluation of the subject's skin condition by two dermatologists who were evaluators directly evaluated the presence or absence of side effects.

In Table 6 below, "0" indicates that the natural product marked "0" in the composition of Table 5 was additionally used. In addition, the content of natural substances used in each example is 02% by weight of white paper, 003% by weight of Coptisium, 02% by weight of licorice, 02% by weight of gold and 02% by weight of burdock. The content of each of these natural products may be formulated differently depending on the type of use, so it is not particularly limited, but in general, it may be formulated in an amount of 0001-10% by weight in cosmetics.

As shown in Table 7 above, the case of Example 11 was the most ideal, and in the case of the Example not including the white paper, the effectiveness was around 20%, whereas the Example containing the white paper showed the effectiveness of 40-50%. It can be seen that the ingredients are effective for acne and synergistically with other natural products. In the case of side effects, mild erythema and itching were observed during the first week after use in all examples, but the degree was weak and not a level to be determined as irritation.

Claims (3)

Cosmetics effective for acne, characterized in that it contains at least one natural product selected from the group consisting of burdock, reduced and white paper among natural products. The cosmetic product effective for acne according to claim 1, wherein the natural product has an effect of inhibiting acne bacteria or inhibiting lipid synthesis. The cosmetic effective for acne according to claim 1 or 2, wherein the natural product is contained in an amount of 0001-10% by weight.

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