KR20200130362A - 항암제로서의 시클릭 디뉴클레오티드 - Google Patents

항암제로서의 시클릭 디뉴클레오티드 Download PDF

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Publication number
KR20200130362A
KR20200130362A KR1020207028422A KR20207028422A KR20200130362A KR 20200130362 A KR20200130362 A KR 20200130362A KR 1020207028422 A KR1020207028422 A KR 1020207028422A KR 20207028422 A KR20207028422 A KR 20207028422A KR 20200130362 A KR20200130362 A KR 20200130362A
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South Korea
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independently
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halogen
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Korean (ko)
Inventor
브라이언 이. 핑크
제밍 루안
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브리스톨-마이어스 스큅 컴퍼니
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Priority to KR1020257026155A priority Critical patent/KR20250125433A/ko
Publication of KR20200130362A publication Critical patent/KR20200130362A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/213—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids containing cyclic phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020207028422A 2018-03-08 2019-03-07 항암제로서의 시클릭 디뉴클레오티드 Ceased KR20200130362A (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020257026155A KR20250125433A (ko) 2018-03-08 2019-03-07 항암제로서의 시클릭 디뉴클레오티드

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862640325P 2018-03-08 2018-03-08
US62/640,325 2018-03-08
PCT/US2019/021145 WO2019173587A1 (en) 2018-03-08 2019-03-07 Cyclic dinucleotides as anticancer agents

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020257026155A Division KR20250125433A (ko) 2018-03-08 2019-03-07 항암제로서의 시클릭 디뉴클레오티드

Publications (1)

Publication Number Publication Date
KR20200130362A true KR20200130362A (ko) 2020-11-18

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Family Applications (2)

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KR1020207028422A Ceased KR20200130362A (ko) 2018-03-08 2019-03-07 항암제로서의 시클릭 디뉴클레오티드
KR1020257026155A Pending KR20250125433A (ko) 2018-03-08 2019-03-07 항암제로서의 시클릭 디뉴클레오티드

Family Applications After (1)

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KR1020257026155A Pending KR20250125433A (ko) 2018-03-08 2019-03-07 항암제로서의 시클릭 디뉴클레오티드

Country Status (7)

Country Link
US (1) US11945834B2 (https=)
EP (1) EP3762397B1 (https=)
JP (1) JP7250808B2 (https=)
KR (2) KR20200130362A (https=)
CN (1) CN111801341B (https=)
ES (1) ES2980374T3 (https=)
WO (1) WO2019173587A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11660311B2 (en) 2017-10-10 2023-05-30 Bristol-Myers Squibb Company Cyclic dinucleotides as anticancer agents
WO2021206158A1 (ja) 2020-04-10 2021-10-14 小野薬品工業株式会社 がん治療方法

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CA2634198C (en) 2005-12-20 2014-06-03 Incyte Corporation N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase
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ES2776406T3 (es) 2007-07-12 2020-07-30 Gitr Inc Terapias de combinación que emplean moléculas de enlazamiento a GITR
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Also Published As

Publication number Publication date
US11945834B2 (en) 2024-04-02
US20210002323A1 (en) 2021-01-07
JP2021515016A (ja) 2021-06-17
CN111801341B (zh) 2023-10-24
CN111801341A (zh) 2020-10-20
EP3762397B1 (en) 2024-05-01
ES2980374T3 (es) 2024-10-01
WO2019173587A1 (en) 2019-09-12
EP3762397A1 (en) 2021-01-13
KR20250125433A (ko) 2025-08-21
JP7250808B2 (ja) 2023-04-03

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