KR20200112598A - Composition For Preventing Of Hair Loss Or Promoting Hair Growth And Scalp and Hair Cosmetics Compring The Same - Google Patents

Abstract

Provided are a composition for preventing hair loss and promoting hair growth, including five kinds of peptides and polyols as active ingredients, and scalp and hair cosmetics comprising the same. The five kinds of peptides may be included in an amount of 0.0001 to 0.5 wt% based on total amount of the composition.

Description

Composition For Preventing Of Hair Loss Or Promoting Hair Growth And Scalp And Hair Cosmetics Compring The Same}

The present description relates to a peptide composition having a protein-like structure excellent in preventing hair loss and promoting hair growth by creating a healthy scalp environment as well as protecting hair, and a scalp and hair cosmetic composition using the same.

As the times change, hair plays an important part in the process of increasing interest in beauty day by day. Hair refers to a thin, keratinized structure produced on the surface of the skin.

In addition to cushioning against external shocks, hair protects the human body from external stimuli such as direct sunlight, cold, friction, and danger, and functions to discharge heavy metals such as arsenic, mercury, and zinc, which are harmful to the body. It is being emphasized.

However, as the number of patients complaining of hair loss due to various causes including a change in dietary life or an increase in internal and external stress is increasing, the development of treatments for this is rapidly emerging as a topic of interest.

Human hair is about 100,000 to 150,000, and each hair has a different growth cycle. The hair growth cycle consists of three stages, specifically the anagen stage, when the hair grows most actively, the catalyst stage when the hair begins to deteriorate, and the telogen stage when the hair growth stops or goes to rest. stage).

In general, alopecia refers to an abnormally large amount of hair dropping out due to the shortening of the hair ratio during the growth phase and the increase of the hair during the degenerative phase or the resting phase during this period.

Male hormones play a very important role in hair death and dropout. Among the factors expressed in hair follicles by male hormones, DKK-1 (Dickkopf-related protein 1) plays an important role in hair follicle growth inhibition and death. Is known.

Meanwhile, for periodic hair growth, regeneration of hair follicles and activation of stem cells must be performed, and this is known to be achieved by the production and activation of Wnt/β-catenin. In addition, since DKK-1 mentioned above is known as an antagonist of Wnt/β-catenin, it can be seen that the above signaling system is very important in regulating hair growth.

Hair and skin are composed of proteins called keratin and collagen, and specifically, hair is a keratin protein containing 14% to 18% cysteine among amino acids. These keratin proteins are a kind of very strong protein under mild conditions such as water or neutral solvents, but can be easily damaged by physical and chemical treatments on the hair such as combing, heat from a dryer, dyeing, and perm occurring in daily life. In addition, recently, the hair is damaged due to various physical, chemical, or environmental factors such as frequent perm and dyeing, and the protein inside the hair is eluted and becomes porous, resulting in rough hair and loss of shine, resulting in poor softness and suppleness. Increasingly, hair care becomes difficult, and the hair becomes thinner and loses elasticity, along with problems such as easily cut off or split ends, resulting in a loss of volume and loss of volume. And, these problems are not necessarily alopecia, but may also cause hair loss.

In recent years, due to the rapidly increasing number of alopecia patients, people's demand for substances capable of improving or preventing hair loss itself, not only in terms of beauty, has been increasing rapidly.

The formulations developed to date for the treatment or prevention of alopecia are formulations based on female hormones for promoting blood circulation, strengthening hair root function, moisturizing the scalp and suppressing male hormones, or formulations containing minoxidil and finasteride. And the like, but there are many restrictions on use due to side effects such as sexual dysfunction, birth defects, and systemic hair growth. Minoxidil was originally a high blood pressure treatment developed to lower blood pressure, but it is a drug that has become more popular now as a hair growth agent as it has hair growth as a side effect of use. However, the minoxidil formulation was found to be unsuitable for long-term use as it causes side effects such as dry scalp and scalp irritation such as erythema, allergic contact dermatitis, facial hirsutism and vasodilation, i.e., collapse due to antihypertensive action, hypotension, and tachycardia. . Like Propecia, a formulation containing phytasteride, which inhibits the production of dihydrotestosterone by inhibiting the action of 5-reductase, is also unsuitable for long-term use as it has various side effects related to sexual function.

Accordingly, research has been actively conducted to treat or prevent alopecia using natural substances.In Korean Patent Registration No. 10-0581316, Chungeulja, Gamsonghyang, Gamguk, Doin, Cornus, Tosaja, Omija, Baekchul, Pine needles and Angelicae It refers to a composition for preventing hair loss and promoting hair growth containing a mixed extract of several herbal medicinal herbs, and Korean Patent Registration No. 10-0609210 contains ethanol extracts of Angelica root and burdock root. It mentions a hair loss prevention shampoo composition that has an inhibitory effect of alpha reductase and an effect of preventing hair loss by improving blood flow by the inulin component of burdock root. However, in many of these cases, the mechanism of action of the clinically appearing hair loss prevention effect cannot be clearly identified, and the effects of scalp elasticity, hair loss prevention, and hair growth promotion are achieved by simultaneously using five peptides as in the present invention. As of yet, nothing is known about having everything.

Accordingly, the present inventors have tried to use a protein-like structure peptide as an active ingredient in an effective anti-vibration composition for promoting hair. As a result, when 5 specific peptides are used together with a polyol, scalp elasticity, hair loss prevention, and hair growth promotion effects are all achieved. By confirming that it can have, the present invention was completed.

One embodiment promotes hair growth by enhancing the activity of the hair follicle to give hair loss prevention effect, has excellent bio stability, gives scalp elasticity, strengthens the strength of the hair, increases the thickness, gives volume (improves root volume), roughness of the cuticle layer It is to provide a composition for preventing hair loss and promoting hair growth, which can impart scalp and hair strengthening effects such as improvement and reduction of breakage.

Another embodiment is to provide a scalp and hair cosmetic material using the composition.

According to one embodiment, there is provided a composition for preventing hair loss and promoting hair growth, comprising 5 kinds of peptides and polyols as active ingredients.

The five kinds of peptides may be included in an amount of 0.0001% to 0.5% by weight based on the total amount of the composition.

The five kinds of peptides include a first peptide composed of a complex of three amino acids and metal ions, a second peptide composed of two amino acids, an acetyl group at four ends, and a third peptide composed of four amino acids, the three A fourth peptide composed of amino acids and a palmitoyl group at the terminal may include a fifth peptide composed of five amino acids.

The first peptide may be included in the largest amount among the five kinds of peptides.

The first peptide is included in an amount greater than that of the second peptide, the second peptide is included in an amount greater than that of the third peptide, and the second peptide is included in an amount greater than that of the fourth peptide, and the second peptide The second peptide may be included in an amount higher than that of the fifth peptide.

The third peptide and the fourth peptide may be included in an amount higher than that of the fifth peptide.

The third peptide and the fourth peptide may be included in the same amount.

The first peptide may be included in an amount of 0.1% to 0.45% by weight based on the total amount of the composition.

The second peptide may be included in an amount of 0.005% to 0.05% by weight based on the total amount of the composition.

The third peptide and the fourth peptide may each independently be included in an amount of 0.001% to 0.01% by weight based on the total amount of the composition.

The fifth peptide may be included in an amount of 0.00001% to 0.001% by weight based on the total amount of the composition.

The first peptide may be copper tripeptide-1.

The second peptide may be carnosine.

The third peptide may be acetyltetrapeptide-3.

The fourth peptide may be tripeptide-1.

The fifth peptide may be palmitoylpentapeptide-4.

The polyol may include glycerin, hexanediol, or a combination thereof.

The polyol may be a mixture of glycerin and 1,2-hexanediol in a weight ratio of 10:1.

The composition may further include purified water.

The composition, based on the total amount of the composition, 0.0001% to 0.5% by weight of the five peptides; 10% to 45% by weight of the polyol; And the remaining amount of purified water.

The composition may be characterized in that it promotes proliferation of dermal papilla cells or hair follicle cells in vitro.

Another embodiment provides a scalp and hair cosmetics comprising the composition.

The scalp and hair cosmetics may further include oils, surfactants, viscosity modifiers, pH modifiers, fragrances, or a combination thereof.

The surfactant may be an anionic surfactant.

The viscosity modifier may be a cationic polymer.

The pH adjusting agent may be isopropanolamine.

The scalp and hair cosmetics may be any one selected from the group consisting of shampoo, hair conditioner, hair tonic, hair gel, hair lotion, hair pack, hair spray, hair mousse, hair treatment, soap, ampoule, and hair dye.

The scalp and hair cosmetics may satisfy Equation 1 below.

[Equation 1]

(Water repellent after 6 weeks of using hair cosmetic / Water repellent after 3 weeks of using hair cosmetic) x 100 <80

According to one embodiment, the composition of the present invention includes 5 types of oligopeptides (those having 2 to 10 amino acids constituting the peptide) with a polyol in a specific combination, thereby having excellent hair and scalp penetration rate. , As a result, hair and scalp conditions can be improved to promote the proliferation of hair follicle cells, and ultimately, hair loss prevention and hair growth promoting effects can be given. Specifically, when the scalp and hair cosmetics containing the composition according to the embodiment are used, the number of removed hairs is significantly reduced compared to before use, as well as the effect of increasing the volume of the roots of new hairs, and reducing the roughness of the cuticle layer in the hair (hair Provides softness to the skin) and cleansing effect against fine dust, which is a recent issue (cleansing effect of fine dust adhering to hair and scalp) is also excellent. Even if the existing scalp and hair cosmetics are changed, no adverse skin reactions are observed (low irritation), so it can be widely and safely used by all age groups. Furthermore, it is possible to realize a desired feeling of use by simply adding a specific type of additive to the composition, so it can be applied to both types of scalp and hair.

1 is a photograph (Folliscope 5.0) evaluating the cleaning power of fine dust of a composition according to Preparation Example 1.
2 is a photograph (Folliscope 5.0) evaluating the cleaning power of fine dust of the composition according to Preparation Example 2.
3 is a scanning electron microscope (SEM) photograph showing the roughness of the cuticle layer of the composition according to Preparation Example 1.
4 is a photograph related to a method of measuring the effect of improving the root volume of newborn hair.
5 is a photograph showing the effect of improving the root volume of new hairs of the composition according to Preparation Example 2.

Hereinafter, embodiments of the present invention will be described in detail so that those of ordinary skill in the art may easily implement the present invention. However, the present invention may be implemented in various different forms, and is not limited to the embodiments described herein.

In the present specification, when a portion such as a layer, a film, a region, or a plate is said to be “on” another portion, this includes not only the case where the other portion is “directly above” but also the case where there is another portion in the middle. Conversely, when one part is "directly above" another part, it means that there is no other part in the middle.

Unless otherwise defined herein, "combination" means mixing or copolymerization. In addition, "copolymerization" means block copolymerization or random copolymerization, and "copolymer" means block copolymer or random copolymer.

Unless otherwise defined in the chemical formula in the present specification, when a chemical bond is not drawn at a position where a chemical bond is to be drawn, it means that a hydrogen atom is bonded at the position.

Unless otherwise defined in the specification, all terms, including technical or scientific terms, used herein have the same meaning as commonly understood by a person of ordinary skill in the art to which the present invention belongs. Terms such as those defined in commonly used dictionaries should be interpreted as having a meaning consistent with the meaning in the context of the related technology, and should not be interpreted as an ideal or excessively formal meaning unless explicitly defined in this application. Does not.

The numerical range includes the numerical values defined in the above range. All maximum numerical limits given throughout this specification include all lower numerical limits as if the lower numerical limits were expressly written. All minimum numerical limits given throughout this specification are inclusive of all higher numerical limits as if the higher numerical limits were expressly written. All numerical limits given throughout this specification will include all better numerical ranges within the wider numerical range, as if the narrower numerical limits were expressly written.

In the present specification, "prevention of hair loss" refers to preventing or weakening the phenomenon that hair is removed from the hair follicle or scalp.

In the present specification, "hair growth" means that the root volume of newborn hair is improved.

Hereinafter, a composition for preventing hair loss and promoting hair growth according to an embodiment will be described.

The composition for preventing hair loss and promoting hair growth according to an embodiment includes 5 types of peptides, specifically the 5 types of peptides and polyols as active ingredients.

Hair follicles are unique organs of mammalian skin, where the lower part of the primitive epidermis grows and extends into a deeper layer of skin. At the base of the hair follicle there is a plug of cells known as follicles or dermal papilla cells (Stenn and Paus, Physiol. Rev., 81: 449 (2002)), and the papilla is the normal circulation of hair follicles (Oliver, Embryol. Exp. Morph. 15 : 3311 (1966); Oliver, Embryol. Exp. Morph. 16: 231 (1966)) and essential for hair shaft growth. The hair shaft is a tread-shaped structure made of tightly adhered epithelial cells filled with keratin filaments and filament aggregation proteins.

Human hair periodically repeats the growth phase, degeneration phase, and resting phase, and the hair goes through the process of being removed and regenerated. The determination of the hair cycle is made through hormonal control or control of many growth factors. On the other hand, hair may undergo a regression period early due to severe stress or nutritional deficiencies, causing severe hair loss ( American Journal of Pathology , 162(3)(2003), (Arck, Petra Clara; Handjiski, Bori). ). In male pattern baldness, hair follicles on the front and top of the scalp are sensitive to androgens. So, in the case of male pattern baldness, it corresponds to the miniaturization of the hair follicle and the destruction of the hair follicle accordingly, which is caused by excessive secretion of the male hormone androgens. Due to the excessive secretion of androgens, 5-alpha reductase is activated and testosterone is transformed into dihydrotestosterone (DHT). The dihydrotestosterone produced in this way shortens the growth period of the hair and reduces the hair follicles, resulting in thick and strong hair. It causes hair loss by reducing the number.

In general, hair loss spreads with age. For example, different disease states such as scar alopecia, scarring conditions associated with burns or compression injuries can cause significant hair loss. To treat such a hair loss phenomenon, various substances have been used as pharmaceuticals so far, but the price is too high and various side effects are caused. In addition, these drugs require continuous use, and when the use is discontinued, hair loss is induced again, individual differences in efficacy are severe, and side effects are also different for each individual.

Other ingredients used as cosmetics have the advantage of being inexpensive, but since they are composed of plant-derived extract ingredients, their effectiveness is not so great. Therefore, there is a demand in the art for a new active ingredient that is effective and more economical in terms of cost.

The two available drugs known to date (minoxidil and finasteride) may delay further hair loss, but did not induce regeneration of new hair follicles. In addition, among the scalp and hair cosmetics, many products for preventing hair loss using plant extracts have been released.In particular, it contains extracts such as gosam, red pepper, sugar drug, sangbaekpi, upper leaf, ginseng, licorice, peony, reindeer, fennel, cornus milk, and garlic. Addition of one product, a composition containing xanthine and growth hormone, improves the inhibition of cell metabolism due to excess dihydrotestosterone, and promotes hair growth by promoting growth hormone, thereby preventing hair loss and regenerating hair to promote hair growth. To promote hair growth and hair growth, products containing minerals and vitamins, green tea, rosemary, mugwort and licorice extracts were developed to provide nutrition to the scalp and hair, and to prevent hair loss and promote hair growth. Effective product, vitamin B, vitamin C, vitamin D, vitamin E, nicotinic acid, pantothenic acid, biotin, folic acid, and other substances and plant extracts are mixed to inhibit 5-alpha reductase in the human body, thereby reducing the metabolism of male hormones. Male-type hair loss products were developed that prevent hydrotestosterone from being formed and help the metabolism of hair, but it was difficult to find a product that affects the formation of new hair.

Furthermore, existing wool hair care products are mainly used for the purpose of improving hair damage by women whose hair has been damaged (thinning, broken, bushy, roughened) due to frequent cosmetic procedures such as perm or dyeing. Currently, hair care products mainly care for the hair surface with cationic raw materials, oils and silicones, and improve hair conditioning, but their retention power is short and fundamental improvement is not possible, so in terms of continuing efficacy and giving actual efficacy to hair. It is a situation that needs improvement. In addition, current wool products are incomplete in terms of biosafety, and even if they have excellent biosafety, the wool effect is insignificant, so that other effects other than the cleaning effect of general hair cosmetic compositions are not exhibited.

The present inventors have undergone numerous trials and errors to discover a peptide having an effective function in improving scalp condition, preventing hair loss and promoting hair growth by enhancing the activity of hair roots while having biological safety. Accordingly, the effect of improving hair growth and scalp condition was investigated. That is, the combination of five peptides having a specific type and content ratio constituting the composition according to one embodiment promotes the growth of hair follicle cells to induce hair growth, and promotes the synthesis of collagen to prevent the growth of damaged scalp tissue. Because it promotes, it is very suitable for use as a composition for preventing hair loss and promoting hair growth.

The peptide (peptide) refers to a polymer composed of one or more amino acids linked by an amide bond (or a peptide bond). For the purposes of the present invention, the peptide may mean a peptide or fragment thereof that simultaneously improves hair loss, promotes hair growth, improves scalp and hair condition, and exhibits a mild effect.

The general rules for naming the peptides may be based on a three-letter or one-letter amino acid code unless otherwise defined in the present specification. For example, the central part of the amino acid structure is indicated by a 3-letter code (eg, Ala, Lys), and the D-stereotype (eg, D-Ala, D-Lys) is specifically specified by writing “D-” in front of the 3-letter code. If it is not described as, it can be assumed to be in L-stereoscopic form. The amino acid residues constituting the peptide may be natural or non-natural amino acid residues.

The composition according to an embodiment relates to a composition for preventing hair loss and promoting hair growth, and more particularly, by including 5 kinds of peptides and polyols as active ingredients, to restore damaged hair, elasticity, strength and softness of the hair Can promote In addition, by returning the period of hair growth damaged by improving the condition of the scalp, it helps to promote hair growth and increases the volume of the roots of the new hair, as well as prevents and prevents hair loss by preventing the generated hair from falling off easily from the scalp. It can give, and furthermore, it can help regenerate the damaged scalp. Furthermore, scalp and hair cosmetics (e.g., shampoo, etc.) comprising the composition according to an embodiment have excellent dust-proofing effect against fine dust, so it is easy to wash away fine dust adhering to the hair when you go out with just one hair washing after returning. I can do it. That is, the scalp and hair cosmetic comprising the composition according to an embodiment may be used not only as a cosmetic for improving the scalp and promoting hair growth, but also as a cosmetic for scalp and hair vibration.

For example, the five kinds of peptides may be included in an amount of 0.0001% to 0.5% by weight, such as 0.1% to 0.4% by weight, such as 0.2% to 0.3% by weight, based on the total amount of the composition. When the five kinds of peptides are included in the above content range, while having biostability, it may have a beneficial effect on hair generation and improvement of damaged scalp conditions. For example, when the five kinds of peptides are included in an amount of less than 0.0001% by weight, such as less than 0.1% by weight, such as less than 0.2% by weight, relative to the total amount of the composition, the content of the five kinds of peptides is too small to have the same effect as not including them. , When the five kinds of peptides are included in an amount of more than 0.5% by weight, such as more than 0.4% by weight, such as more than 0.3% by weight, relative to the total amount of the composition, biosafety may be degraded, and furthermore, the crude liquid of the composition may be difficult.

For example, the five kinds of peptides are a first peptide composed of a complex of three amino acids and metal ions, a second peptide composed of two amino acids, an acetyl group at four ends, and a third peptide composed of four amino acids, the A fourth peptide composed of three amino acids and a palmitoyl group at the terminal may be composed of a fifth peptide composed of five amino acids. Since all of the five peptides have 5 or less amino acids, they have a small molecular weight (size), which improves the permeability to the scalp and hair, and ultimately helps promote hair growth and scalp tissue growth.

The five kinds of peptides are preferably composed of the first peptide, the second peptide, the third peptide, the fourth peptide, and the fifth peptide, and when other kinds of peptides other than the five kinds are included, the hair growth promoting effect is It may be degraded and may be undesirable.

Meanwhile, the content ratio between the five kinds of peptides may also be important. For example, the first peptide may be included in the highest amount among the five kinds of peptides. The first peptide is a complex compound of three amino acids and metal ions, and when the metal ion is a copper ion, the first peptide has a 5-α-reductase inhibitory effect and can help hair growth, and collagen production and Due to the anti-inflammatory effect, it plays a big role in helping the regeneration of the wounded scalp, and it is more preferable in terms of promoting hair growth and improving scalp condition that the first peptide is contained in the largest amount among the five peptides. I can.

For example, the first peptide is included in a higher content than the second peptide, the second peptide is included in a higher content than the third peptide, and the second peptide is included in a higher content than the fourth peptide, The second peptide may be included in an amount higher than that of the fifth peptide. For example, the third peptide and the fourth peptide may be included in an amount higher than that of the fifth peptide. For example, the third peptide and the fourth peptide may be included in the same amount as each other. That is, the content ratio between the five peptides is'first peptide> second peptide> third peptide ≥ fourth peptide> fifth peptide' or'first peptide> second peptide> fourth peptide ≥ third peptide> It may be a fifth peptide', and this content ratio may be most preferable in terms of promoting hair growth and improving scalp condition.

For example, the first peptide may be Copper Tripeptide-1. The copper tripeptide-1 can play a role as a kind of regenerative peptide, can help promote hair growth and collagen synthesis, and above all, show excellent efficacy in wound healing, essential for improving damaged scalp tissue. It may be one of the constituent peptides that should be included as. In addition, it can play an antioxidant role, and it helps to generate extracellular matrix such as elastin, proteoglycan, glycosaminoglycan, etc., preventing the loss of moisture in the scalp skin and helping to maintain elasticity. give.

On the other hand, dihydrogestosterone, which is a substance converted from testosterone, is known to induce androgenic hair loss. The dihydrotestosterone binds to the androgen receptor present in the hair follicle cells and enters the dermal papilla cells, and in this process, it produces hair follicle cell-destroying substances including TGF-β, DKK-1, BMP, etc., causing hair loss.

In other words, it is possible to reduce the amount of dihydrotestosterone production, block the entry path to the hair follicle cells, or achieve the effect of improving hair loss or hair growth through the regeneration of the hair follicle cells, which can be used as the first peptide. Peptide-1 can inhibit the action of an enzyme called 5-α-reductase, as described above, and can significantly inhibit the production of dihydrotestosterone, which ultimately leads to excellent hair loss through the action of growing hair follicle cells. Improvement or hair growth effect can be achieved.

For example, the first peptide may be included in an amount of 0.1% to 0.45% by weight, such as 0.15% to 0.4% by weight, such as 0.2% to 0.3% by weight, based on the total amount of the composition.

For example, the second peptide may be carnosine. The carnosine has two amino acids bonded (beta Ala-His; beta AH) to have anti-glycosylation and antioxidant efficacy, and thus can serve as a kind of antioxidant peptide. Because it has anti-glycosylation effect, it can prevent damage to collagen and elastin caused by binding to sugar or oxidative stress, and it can help the cells of the scalp to function normally.

For example, the second peptide may be included in an amount of 0.005% to 0.05% by weight, such as 0.007% to 0.04% by weight, such as 0.01% to 0.03% by weight, based on the total amount of the composition.

For example, the third peptide may be Acetyl Tetrapeptide-3, which may serve as a volume peptide. The acetyltetrapeptide-3 is a combination of four amino acids (acetyl-KGHK), and, like the first peptide, has a 5-α-reductase inhibitory effect, so it can help hair growth, collagen production and laminin. It can help to form a healthy scalp condition from the inside by stimulating and strengthening the extracellular matrix.

For example, the fourth peptide may be Tripeptide-1, which may serve as a carrier peptide. The tripeptide-1 has the same sequence (GHK) as copper tripeptide-1, except that there is no copper ion (Cu ²⁺ ), compared to copper tripeptide-1 that can be used as the first peptide, and the copper The ion (Cu ²⁺ ) can play a role of stably delivering active ingredients such as copper ions so that a complex compound such as copper tripeptide-1 can be formed well. Furthermore, tripeptide-1 itself can help in the production of collagen, elastin and extracellular matrix, so it can help to form a scalp condition in which hair follicle cells can grow well.

For example, the third peptide and the fourth peptide may each independently be included in an amount of 0.001% to 0.01% by weight, such as 0.003% to 0.007% by weight, based on the total amount of the composition.

For example, the fifth peptide may be palmitoyl pentapeptide-4, which may serve as a line peptide. The palmitoylpentapeptide-4 has five amino acids bonded (KTTKS), which stimulates the production of collagen and elastin in the dermal layer, thereby alleviating the curvature of the skin and preventing wrinkles. The palmitoylpentapeptide-4 plays a role in increasing the synthesis of hyaluronic acid, through which it gives moisturizing power to the scalp to cool the scalp and improves the elasticity of the scalp, a scalp condition in which hair follicle cells can grow well. Can help to shape. However, the palmitoyl pentapeptide-4 exhibits an excellent effect on relieving skin flexion and wrinkle formation through collagen synthesis promotion, so if it is used in excess when preparing the composition according to one embodiment, a composition containing five peptides In order to cause a decrease in the stability of and the quality of the scalp and hair cosmetics including the same, it may be preferable to contain the smallest amount of the five kinds of peptides.

For example, the fifth peptide may be included in an amount of 0.00001% to 0.001% by weight, such as 0.00005% to 0.0003% by weight, such as 0.00007% to 0.0002% by weight, based on the total amount of the composition.

Since the composition according to one embodiment contains the five kinds of peptides of the above-described configuration as an active ingredient, it can promote the proliferation of dermal papilla cells or hair follicle cells in vitro, and therefore, the composition according to one embodiment prevents hair loss and prevents hair loss. It can exhibit excellent effects in promoting growth.

The "contained as an active ingredient" refers to hair loss improvement, hair growth promotion, fine dust cleaning or skin improvement effect, for example, inhibition of dihydrotestosterone related to hair growth efficacy, improvement of fundamental scalp elasticity, hair and scalp It may be meant to contain an effective amount of a degree capable of promoting collagen synthesis related to the anti-vibration effect and hair follicle strengthening.

On the other hand, the composition according to one embodiment includes a polyol. The polyol may include, for example, butylene glycol, propylene glycol, dipropylene glycol, sorbitol, glycerin, diglycerin, glycerin, isopentyldiol, propanediol, hexanediol, or a combination thereof. For example, the polyol may include glycerin, hexanediol, or a combination thereof. Specifically, the polyol is a mixture of glycerin and 1,2-hexanediol, and more specifically, the polyol is glycerin and 1,2-hexanediol. It may be desirable to be a mixture mixed in a weight ratio of :1. By using a mixture in which glycerin and 1,2-hexanediol are mixed in a weight ratio of 10:1 as the polyol, it is possible to increase the spreadability and water absorption of the composition according to the embodiment, which makes the composition for hair bundles. By helping to spread evenly, it can give a care effect to the hair strands. In addition, if the glycerin and 1,2-hexanediol are not mixed in a weight ratio of 10:1, the stability of the formulation may be deteriorated or adverse skin irritation may be caused, which is not preferable. In addition, the 1,2-hexanediol may also play a role as a preservative, and if the polyol does not contain 1,2-hexanediol, the composition may easily perish, which is not preferable.

For example, the composition may further include purified water, and in this case, the composition according to an embodiment may include 0.0001% to 0.5% by weight of the five peptides based on the total amount of the composition; 10% to 45% by weight of the polyol; And the remaining amount of the purified water (eg, 54.5% by weight to 79.5% by weight). When the 5 kinds of peptides, polyols, and purified water are included in the above content ranges, the hair growth promoting effect is not impaired, and at the same time, it exhibits excellent effects in relieving tangling and improving elasticity. In particular, the composition according to an embodiment may contain a considerably larger amount of polyol compared to the conventional hair cosmetic composition, which facilitates the crude liquid without inhibiting the hair growth promoting effect of the five kinds of peptides, and the hair cosmetic composition It is intended to be used easily.

Another embodiment provides a scalp and hair cosmetic comprising the above-described composition.

In addition to the composition, the scalp and hair cosmetics include oils, surfactants, viscosity modifiers, pH modifiers, fragrances, or combinations thereof, which are widely known and used by experts in the field as conventional optional ingredients for maintaining basic physical properties and quality in addition to the composition. It may be contained, and as a solvent, in addition to purified water, deionized water, ethanol, isopropyl alcohol, and the like may be further included.

More specifically, the scalp and hair cosmetics may further include a viscosity modifier (cationic polymer) and a surfactant (eg, anionic surfactant) along with the five kinds of peptides and polyols.

The cationic polymer may include natural cationic polymers such as cation guar such as guar hydroxypropyltrimonium chloride, hydroxypropyl guar hydroxypropyltrimonium chloride, and polyquaternium-10; And dimethyldiallylammonium chloride polymer, acrylamide-dimethyldiallylammonium chloride copolymer, PVP-dimethylaminoethyl methacrylate copolymer, acrylic acid-dimethyldiallylammonium chloride copolymer, acrylamide-dimethylamino ethylmethacrylate methyl Any one or more cationic polymers selected from the group consisting of synthetic cationic polymers such as chloride copolymer, trimethylaminoethyl methacrylate polymer, etc. may be used alone or in combination within the range not impairing the object of the present invention, but must be It is not limited thereto.

The surfactant may be an anionic surfactant, and as the anionic surfactant, sulfosuccinate-based, sodium cocoyl isethionate, sodium methylcocoyl taurate, sodium lauroyl sarcosinate, and sodium ra Any one or more selected from the group consisting of uril sulfoacetate and the like may be used. In this case, as the sulfosuccinate-based, disodium lauryl sulfosuccinate, disodium laureth sulfosuccinate, or the like may be used.

Depending on what kind of additives the scalp and hair cosmetics contain, the feeling of use of the finally produced cosmetic can be differently adjusted, and therefore, depending on the type of hair or scalp, for example, whether it is dry or oily, the user's desired feeling and desired effect Cosmetics having a can be provided.

For example, in the case of users with dry hair or scalp, scalp and hair cosmetics containing the natural cationic polymer and anionic surfactant, such as sulfosuccinate surfactant, such as disodium laureth sulfosuccinate, are used. Using it can be advantageous in terms of improving the number of hair dropouts, improving the softness of the hair due to the reduction in the roughness of the cuticle layer, and improving the cleaning power of fine dust. In particular, when a sulfosuccinate-based surfactant is used as the anionic surfactant and a natural cationic polymer is used as the cationic polymer at the same time, it has excellent compatibility with the five kinds of peptides and polyols. Compared to the case of using additives (cationic surfactants, nonionic surfactants, amphoteric surfactants, synthetic cationic polymers, anionic polymers, etc.), the effect of providing softness to the hair by reducing the roughness of the cuticle layer is very good. And can provide a soft feeling of use. In addition, even if the natural cationic polymer and anionic surfactant are used at the same time, if the five kinds of peptides and polyols are not used together, the compatibility between the constituents is greatly reduced, and the above-described effects cannot be realized.

On the other hand, the scalp and hair cosmetics may further include a pH adjusting agent instead of the viscosity adjusting agent and surfactant.

The pH adjusting agent is acetic acid, lactic acid, adipic acid, aminoethyl propanediol, aminomethyl propanediol, aminomethyl propanol, aminopropanediol, ascorbic acid, azelaic acid, benzoic acid, butyl diethanolamine, butylethanolamine , Citric acid, dibutyl ethanolamine, diethanolamine, diisopropylamine, diisopropanolamine, dimethyl isopropanolamine, decylethanolamine, galacturonic acid, glycolic acid, isopropanolamine, isopropylamine , Malic acid, malonic acid, and methylethanolamine, and more specifically, isopropanolamine may be used. In general, when triisopropanolamine is used in cosmetics, it has excellent pH control, but has a side effect of severe skin irritation, which has always been a problem. According to one embodiment, triisopropanol is not used as a pH adjusting agent, so that low-irritant properties can be effectively implemented, and more specifically, by using isopropanolamine as a pH adjusting agent, the effect of increasing the volume of the roots of newborn hair can be excellently implemented.

For example, in the case of a user with oily type of hair or scalp, using a scalp and hair cosmetic comprising the pH adjusting agent may be advantageous in terms of improving the number of hair loss, increasing the volume of new hair roots, and improving fine dust cleaning power. In particular, when isopropanolamine is used as the pH adjusting agent, it has excellent compatibility with the 5 types of peptides and polyols, so that the effect of increasing the volume of the root of newborn hair can be greatly improved compared to the case of using other types of pH adjusting agents. , It can provide a heavy feel rather than soft. In addition, even if isopropanolamine is used as the pH adjusting agent, if the five kinds of peptides and polyols are not used together, compatibility between components is greatly reduced, and the above-described effect cannot be realized.

The scalp and hair cosmetics may be any one selected from the group consisting of shampoo, hair conditioner, hair tonic, hair gel, hair lotion, hair pack, hair spray, hair mousse, hair treatment, soap, ampoule, and hair dye. For example, the scalp and hair cosmetic may be a hair conditioner composition, such as a shampoo, treatment, rinse or essence. The ampoule may mean a small bottle or the like containing the composition according to an embodiment.

For example, the scalp and hair cosmetic may satisfy Equation 1 below.

[Equation 1]

(Water repellent after 6 weeks of using hair cosmetic / Water repellent after 3 weeks of using hair cosmetic) x 100 ≤ 80

That is, in the case of washing hair using the hair cosmetic according to an embodiment, the number of hair removal after 6 weeks than the number of hair removal after 3 weeks is 20% or more, such as 21% or more, such as 22% or more, such as 23% or more, such as 24 % Or more, such as 25% or more, such as 30% or more.

In the present specification, "cosmetics" may mean all substances that may have additional medical functions in addition to cosmetic functions as well as cosmetic functions.

The formulation of the hair cosmetic is not particularly limited, and may be appropriately selected depending on the purpose.

For example, the hair cosmetics are formulated as solutions, suspensions, emulsions, pastes, gels, creams, lotions, powders, soaps, surfactant-containing cleansing, oils, powder foundations, emulsion foundations, wax foundations and sprays. May be, but is not limited thereto. More specifically, cleaning agents such as shampoo and conditioner, hair tonic, hairdressing agents such as gel or mousse, hair nutrient lotion, hair essence, hair serum, hair treatment, hair conditioner, hair shampoo, hair lotion, wool or hair dye, etc. To be formulated as basic cosmetics such as oil-in-water (O/W) type, water-in-oil (W/O) type, multi-emulsion (W/O/W or O/W/O) type, solubilization type, etc. I can. In addition, the hair cosmetics may be appropriately selected and blended by those skilled in the art without difficulty according to the type or purpose of use of other external preparations, in addition to the above essential ingredients in each formulation. For example, it may further include a sunscreen agent, a hair conditioning agent, fragrance, and the like.

The hair cosmetic composition may contain a cosmetically acceptable medium or base. These are all formulations suitable for topical application, for example solutions, gels, solid or paste anhydrous products, emulsions obtained by dispersing the oil phase in an aqueous phase, suspensions, microemulsions, microcapsules, microgranules or ionic (liposomes) and/or It may be provided in the form of a nonionic vesicle dispersant, or in the form of a cream, skin, lotion, powder, ointment, spray or conceal stick. These hair cosmetics can be prepared according to conventional methods in the art.

When the formulation of the present invention is a solution or emulsion, a solvent, a solubilizing agent or an emulsifying agent is used as a carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1 ,3-butylene glycol, oil, glycerol, aliphatic esters, polyethylene glycol or fatty acid esters of sorbitan.

When the formulation of the present invention is a suspension, a liquid diluent such as water, ethanol or propylene glycol as a carrier component, a suspending agent such as ethoxylated isostearyl alcohol and polyoxyethylene sorbitan ester, microcrystalline cellulose, aluminum methhydride Lockside, bentonite, agar or tracant, and the like may be used.

When the formulation of the present invention is a paste, cream or gel, animal oil, vegetable oil, wax, paraffin, starch, tracanth, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc, or zinc oxide may be used as carrier components. I can.

When the formulation of the present invention is a powder or spray, lactose, talc, silica, aluminum hydroxide, calcium silicate, or polyamide powder may be used as a carrier component. In particular, in the case of a spray, additionally chlorofluorohydrocarbon, propane / May contain propellants such as butane or dimethyl ether.

In one embodiment of the present invention, a thickener may be additionally included in the hair cosmetic composition. The thickening agent included in the hair cosmetic composition of the present invention is methyl cellulose, carboxy methyl cellulose, carboxy methyl hydroxy guanine, hydroxy methyl cellulose, hydroxyethyl cellulose, carboxy vinyl polymer, polyquaternium, cetearyl alcohol, stearic acid, Carrageenan or the like may be used, preferably at least one of carboxy methyl cellulose, carboxy vinyl polymer, and polyquaternium may be used, and most preferably carboxy vinyl polymer may be used.

In one embodiment of the present invention, the hair cosmetics may contain various suitable bases and additives as needed, and the types and amounts of these ingredients can be easily selected by the inventor. It may contain acceptable additives as needed, and for example, it may further include components such as preservatives, colors, additives, etc. that are common in the art.

The preservative may specifically be phenoxyethanol, and the like, and the fragrance may be an artificial fragrance.

And, in one embodiment of the present invention, the hair cosmetic composition may include a composition selected from the group consisting of water-soluble vitamins, oil-soluble vitamins, polymer peptides, polymer polysaccharides, sphingo lipids, and seaweed extract. Other ingredients that may be added include fats and oils, moisturizers, emollients, surfactants, organic and inorganic pigments, organic powders, ultraviolet absorbers, preservatives, fungicides, antioxidants, plant extracts, pH adjusters, alcohols, pigments, fragrances, Blood circulation accelerators, cooling agents, limiting agents, purified water, and the like.

In addition, the blending components that may be added are not limited thereto, and any of the above components can be blended within a range that does not impair the object and effect of the present invention.

The five peptides are excellent in preventing hair loss and promoting hair growth due to improvement of the scalp condition by promoting the proliferation of hair follicle cells, and can be used not only for hair cosmetic compositions but also for pharmaceutical compositions or skin external preparations. have.

The pharmaceutical composition may form a pharmaceutically acceptable acid addition salt according to a method conventional in the art. The free acid may be an organic acid or an inorganic acid, for example, the inorganic acid may be hydrochloric acid, bromic acid, sulfuric acid, or phosphoric acid, and the organic acid may be citric acid, acetic acid, lactic acid, tartaric acid, maleic acid, fumaric acid. (Fumaric acid), formic acid, propionic acid, oxalic acid, trifluoroacetic acid, benzoic acid, gluconic acid, methanesulfonic acid, glycolic acid, succinic acid, 4-toluenesulfonic acid, benzenesulfonic acid, salicylic acid, It may be nicotinic acid, isonicotinic acid, picolinic acid, glutamic acid, or aspartic acid, but is not limited thereto.

The pharmaceutical composition may further include carriers, excipients, and diluents that are commonly used.

The pharmaceutical composition may be administered in the form of oral delivery or parenteral delivery. The peptide may be administered systemically or locally, and the administration may include oral administration and parenteral administration. In this case, it may be formulated with an appropriate amount of a pharmaceutically acceptable vehicle or carrier to provide an appropriate dosage form.

In addition, the composition including the five kinds of peptides may further include a carrier, an excipient, and a diluent used in the manufacture of a pharmaceutical composition.

The carrier, excipient and diluent include lactose, dextrose, sucrose, sorbitol, mannitol, xylitol, erythritol, maltitol, starch, gum acacia, alginate, gelatin, calcium phosphate, calcium silicate, cellulose, methyl cellulose, microcrystalline Cellulose, polyvinyl pyrrolidone, water, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate, or mineral oil may be mentioned, but the present invention is not limited thereto.

In addition, the composition containing the five kinds of peptides can be formulated and used in the form of oral dosage forms such as powders, granules, tablets, capsules, suspensions, emulsions, syrups, and aerosols, external preparations, suppositories, and sterile injectable solutions.

The solid preparations for oral administration include tablets, pills, powders, granules, capsules, etc., and the solid preparations contain at least one excipient, such as starch, calcium carbonate, sucrose, lactose, in the peptide and its fractions, Alternatively, it can be prepared by mixing gelatin or the like. In addition to the above excipients, lubricants such as magnesium stearate and talc may be used.

As the liquid preparation for oral administration, a suspension, a liquid solution, an emulsion, a syrup, etc. may be used, and various excipients, such as a wetting agent, a sweetening agent, a fragrance, a preservative, etc., may be used in addition to water and liquid paraffin which are simple diluents. have.

The formulation for parenteral administration may be a sterile aqueous solution, a non-aqueous solvent, a suspension, an emulsion, a lyophilized formulation, or a suppository. As the non-aqueous solvent and suspending agent, propylene glycol, polyethylene glycol, vegetable oil such as olive oil, and injectable ester such as ethyl oleate may be used. As a base for the suppository, witepsol, macrogol, tween 61, cacao butter, laurin paper, and glycerogelatin may be used.

The pharmaceutical composition may be administered as an individual therapeutic agent or administered in combination with other therapeutic agents, may be administered sequentially or simultaneously with a conventional therapeutic agent, and may be administered single or multiple. It is preferable to administer an amount capable of obtaining the maximum effect in a minimum amount without side effects in consideration of all the above factors, and this can be easily determined by a person skilled in the art.

Meanwhile, the external preparation for skin may be formulated by a conventional method. Remington's Pharmaceutical Science, Mack Publishing Company, Easton PA for the formulation of external preparations for skin may be referred to.

Specifically, the external preparation for skin may be formulated as an ointment, patch, gel (gel), cream, or spray, but is not limited thereto.

The external preparation for skin may be appropriately blended with other ingredients within a range that does not impair the object according to the present invention depending on the type or purpose of use, in addition to the essential ingredients in each formulation.

The external preparation for skin may include a generally acceptable carrier, and for example, oil, water, surfactant, moisturizing agent, lower alcohol, thickener, chelating agent, pigment, preservative, fragrance, etc. may be appropriately blended, but are limited thereto. no.

The acceptable carrier may vary depending on the formulation. For example, when formulated as an ointment, cream or gel (gel), animal oil, vegetable oil, wax, paraffin, starch, tracant, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc, zinc oxide or Mixtures of these can be used

When the external preparation for skin is formulated as a powder or spray, lactose, talc, silica, aluminum hydroxide, calcium silicate, polyamide powder, or mixtures thereof may be used as a carrier component, and chlorofluorohydrogen It may further comprise a propellant such as carbon, propane, butane or dimethyl ether.

When the skin external preparation is formulated as a solution or emulsion, a solvent, a solubilizing agent, or an emulsifying agent may be used as a carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl benzoate, propylene glycol, 1,3-Butylglycol oil may be used, and in particular cottonseed oil, peanut oil, corn germ oil, olive oil, castor oil and sesame oil, glycerol aliphatic ester, polyethylene glycol or fatty acid ester of sorbitan may be used.

When the external preparation for skin is formulated as a suspension, as a carrier component, a liquid diluent such as water, ethanol or propylene glycol, an ethoxylated isostearyl alcohol, a suspending agent such as polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, Microcrystalline cellulose, aluminum metahydroxide, bentonite, agar or tracant, and the like can be used.

The external preparations for skin are fatty substances, organic solvents, solubilizers, thickeners, gelling agents, emollients, antioxidants, suspending agents, stabilizers, foaming agents, and fragrances commonly used in the industry depending on the quality or function of the final product. , Surfactants, water, ionic or nonionic emulsifiers, fillers, sequestering agents, chelating agents, preservatives, blocking agents, wetting agents, essential oils, dyes, pigments, hydrophilic or lipophilic activators, commonly used in cosmetics It may additionally contain adjuvants commonly used in the field of cosmetology or dermatology, such as any other ingredients.

However, the adjuvant and the mixing ratio thereof may be appropriately selected so as not to affect the desirable properties of the composition according to the present invention.

The embodiments of the present invention described above will be described in more detail through the following examples. However, the following examples are for illustrative purposes only and do not limit the scope of the present invention.

Preparation and evaluation of hair cosmetic composition

(Production example)

Preparation Example 1, Preparation Example 2, and Comparative Preparation Example 1 to Comparative Preparation Example 7 were prepared in the composition and content shown in Table 1 below. The raw materials were sequentially dispersed and added and stirred until a homogeneous phase was obtained after each raw material was added. The composition of Preparation Example 1, Preparation Example 2, and Comparative Preparation Examples 1 to 7 was evaluated for the number of hair loss, fine dust cleaning power, new hair root volume, cuticle layer roughness and hypoallergenicity, and the results are shown in Table 2 below. It is shown in Table 5.

(Unit: wt%) Manufacturing Example 1 Manufacturing Example 2 Comparative Production Example 1 Comparative Production Example 2 Comparative Production Example 3 Comparative Production Example 4 Comparative Production Example 5 Comparative Production Example 6 Comparative Production Example 7 Purified water To 100 To 100 To 100 To 100 To 100 To 100 To 100 To 100 To 100 glycerin 30 30 30 30 30 30 30 30 30 1,2-hexanediol 3 3 3 3 3 3 3 3 3 First peptide 0.2 0.2 - 0.2 0.2 0.2 0.2 - - Second peptide 0.01 0.01 0.01 - 0.01 0.01 0.01 0.01 0.01 Third peptide 0.005 0.005 0.005 0.005 - 0.005 0.005 0.005 0.005 Fourth peptide 0.005 0.005 0.005 0.005 0.005 - 0.005 0.005 0.005 Fifth peptide 0.0001 0.0001 0.0001 0.0001 0.0001 0.0001 - 0.0001 0.0001 Disodium laureth sulfosuccinate 11 - - - - - - 11 - Polyquaternium-10 0.25 - - - - - - 0.25 - Isopropanolamine - 2 - - - - - - 2

First Peptide: Copper Tripeptide-1

Second Peptide: Carnosine

Third peptide: Acetyl Tetrapeptide-3

Fourth peptide: Tripeptide-1

Fifth peptide: Palmitoyl Pentapeptide-4

(Evaluation 1: number of hair loss)

In order to evaluate the effect of improving the number of hair loss of the compositions prepared according to Preparation Example 1, Preparation Example 2, and Comparative Preparation Examples 1 to 7, the following clinical experiments were conducted on adult males and females.

A total of 161 healthy adults aged 18 to 65 years old, with no infectious skin disease or chronic physical disease, with 80 hair loss or more per day, divided into 7 groups of 23 people, and shampoos prepared with the compositions of the above Preparation Examples and Comparative Preparation Examples were used. After sufficiently moistening the hair and scalp with warm water once a day, apply an appropriate amount evenly to the hair and scalp, massage, rinse thoroughly with water, and use for a total of 6 weeks. Immediately before using shampoo, 3 weeks after using shampoo, use shampoo Divided into 6 weeks after, the number of hairs removed during shaving was counted and measured, and the results are shown in Table 2 (Mean±SD) below. It means that as the number of hairs dropped off during hair removal decreases, it is more effective in improving the number of removed hairs.

(Unit: number) Just before using shampoo 3 weeks after shampoo use 6 weeks after shampoo use Manufacturing Example 1 36.095±36.348 18.952±14.002 13.524±14.573 Manufacturing Example 2 39.043±29.438 20.565±12.745 13.652±10.066 Comparative Production Example 1 36.547±34.142 34.079±25.394 30.845±24.510 Comparative Production Example 2 36.261±31.808 35.347±22.381 31.839±20.168 Comparative Production Example 3 37.912±35.877 34.316±22.041 33.063±18.477 Comparative Production Example 4 39.214±31.856 35.913±25.305 33.367±19.823 Comparative Production Example 5 38.712±29.236 35.360±25.018 30.495±18.623 Comparative Production Example 6 38.263±27.141 34.853±26.711 31.231±20.804 Comparative Production Example 7 37.225±24.302 33.801±25.144 32.637±20.410

From Table 2, it can be seen that the shampoo prepared with the composition according to Preparation Example 1 and Preparation Example 2 has a very excellent effect of improving the number of hair loss than the shampoo prepared with the composition according to Comparative Preparation Example 1 to Comparative Preparation Example 7.

(Evaluation 2: Fine dust cleaning power)

In order to evaluate the fine dust cleaning effect of the compositions prepared according to Preparation Example 1, Preparation Example 2 and Comparative Preparation Examples 1 to 7, a clinical experiment was conducted in the same manner as in Evaluation 1, and the results are shown in Table 3 below. It is shown in Figures 1 and 2.

The fine dust cleaning power was measured by applying a fine dust mimic (Carbon powder; Merk, USA) to the scalp and hair of the test subject. Using Folliscope 5.0 (Lead M, Korea), the scalp and hair were measured before using the shampoo, after applying the microdust mimic, and immediately after use, and the extracted images were image analysis program Image-pro ^® plus (Media Cybernetics, USA) After designating the area of only the microscopic dust mimic using, the color intensity difference was analyzed.

When a lot of fine dust mimics are erased, the color becomes brighter and the intensity increases. The cleaning effect is corrected by subtracting each intensity value from the maximum value of 255 in the color range (0-255), and the larger the cleaning effect, the lower the result.

(Mean±SD) 255-Intensity Just before using shampoo After applying fine dust mimic Immediately after using shampoo Manufacturing Example 1 91.424±14.603 140.013±11.096 95.982±14.430 Manufacturing Example 2 101.524±11.418 133.803±9.574 110.248±11.161 Comparative Production Example 1 97.510±15.011 140.841±10.321 134.544±9.639 Comparative Production Example 2 96.209±13.879 141.003±8.637 135.349±8.910 Comparative Production Example 3 97.141±14.914 140.633±9.478 135.865±9.102 Comparative Production Example 4 98.948±15.396 141.745±10.953 136.659±10.211 Comparative Production Example 5 97.177±14.781 140.352±10.316 135.885±8.637 Comparative Production Example 6 97.231±14.522 141.019±10.358 136.327±7.443 Comparative Production Example 7 99.256±12.617 142.341±10.984 136.869±8.360

From Table 3, FIGS. 1 and 2, the shampoo prepared with the composition according to Preparation Example 1 and Preparation Example 2 has very excellent fine dust cleaning power than the shampoo prepared with the composition according to Comparative Preparation Examples 1 to 7 I can confirm.

(Evaluation 3: stimulation test)

In order to evaluate the skin irritation of the compositions prepared according to Preparation Example 1, Preparation Example 2 and Comparative Preparation Examples 1 to 7, a clinical experiment was conducted in the same manner as in Evaluation 1, and the results are shown in Table 4 below. Done.

The evaluation of skin irritation was conducted in such a way that the researcher visually checked whether erythema, swelling, and scales were produced, and whether the experimenter had irritation for each item of itching, stinging, burning, stiffness and tingling.

Researcher evaluation results Survey result of experimenter Erythema edema Scale creation itch sting Burning sensation Stiffness Tingling Manufacturing Example 1 Ⅹ Ⅹ Ⅹ Ⅹ Ⅹ Ⅹ Ⅹ Ⅹ Manufacturing Example 2 Ⅹ Ⅹ Ⅹ Ⅹ Ⅹ Ⅹ Ⅹ Ⅹ Comparative Production Example 1 ○ Ⅹ Ⅹ Ⅹ Ⅹ Ⅹ Ⅹ Ⅹ Comparative Production Example 2 Ⅹ Ⅹ Ⅹ ○ Ⅹ Ⅹ Ⅹ Ⅹ Comparative Production Example 3 Ⅹ Ⅹ Ⅹ ○ Ⅹ Ⅹ Ⅹ Ⅹ Comparative Production Example 4 Ⅹ Ⅹ Ⅹ Ⅹ ○ ○ Ⅹ Ⅹ Comparative Production Example 5 Ⅹ Ⅹ Ⅹ ○ Ⅹ Ⅹ Ⅹ Ⅹ Comparative Production Example 6 Ⅹ Ⅹ Ⅹ Ⅹ Ⅹ Ⅹ Ⅹ ○ Comparative Production Example 7 Ⅹ Ⅹ Ⅹ Ⅹ Ⅹ Ⅹ ○ Ⅹ

(○: corresponding stimulus observed / ⅹ: corresponding stimulus not observed)

From Table 4, it can be seen that the shampoo prepared with the composition according to Preparation Example 1 and Preparation Example 2 had less skin irritation than the shampoo prepared with the composition according to Comparative Preparation Example 1 to Comparative Preparation Example 7.

(Evaluation 4: roughness of cuticle layer)

In order to evaluate the effect of alleviating the roughness of the cuticle layer of the compositions prepared according to Preparation Examples 1, 2 and Comparative Preparation Examples 1 to 7, a clinical experiment was conducted in the same manner as in Evaluation 1, and the results are shown in Table 5 And shown in FIG. 3.

To measure the cuticle, the hair damaged by hot air balloons, dyeing and perm collected from the experimenter was photographed with a scanning electron microscope (SEM) before and after shampoo use, and then the Skin Visiometer ^® SV700 (Courage+Khazaka electronic GmbH, Germany) equipment was used. The roughness (R3) of the hair cuticle was evaluated using. The lower the R3 value, the more healthy hair is improved.

(Mean±SD) Just before using shampoo 3 weeks after shampoo use 6 weeks after shampoo use Manufacturing Example 1 0.323±0.102 0.277±0.089 0.227±0.039 Manufacturing Example 2 0.335±0.110 0.310±0.097 0.302±0.084 Comparative Production Example 1 0.334±0.140 0.314±0.121 0.302±0.098 Comparative Production Example 2 0.331±0.089 0.311±0.099 0.301±0.083 Comparative Production Example 3 0.332±0.103 0.312±0.097 0.303±0.105 Comparative Production Example 4 0.333±0.088 0.323±0.102 0.317±0.094 Comparative Production Example 5 0.332±0.101 0.313±0.081 0.305±0.116 Comparative Production Example 6 0.331±0.111 0.310±0.093 0.299±0.062 Comparative Production Example 7 0.331±0.093 0.312±0.175 0.306±0.073

From Table 5 and Figure 3, the shampoo prepared with the composition according to Preparation Example 1 significantly reduced the roughness of the cuticle layer than the shampoo prepared with the composition according to Preparation Example 2 and Comparative Preparation Examples 1 to 7 I can confirm.

(Evaluation 5: Root Volume of Newborn Hair)

In order to evaluate the effect of the root volume of newborn hairs of the compositions prepared according to Preparation Examples 1, 2 and Comparative Preparation Examples 1 to 7, a clinical experiment was conducted in the same manner as in Evaluation 1, and the results are shown in Table 6 below. (Mean±SD), shown in FIGS. 4 and 5.

For the measurement of the new hair root volume, the same forehead area was photographed with a DSLR (Canon EOS 800D, Japan) before and after using the test product, and the photographed image was analyzed with Image-pro ^® plus. The analysis was performed in the following order, and it means that the larger the angle, the more effective the root volume of the new hairs of the bangs is improved.

① At the end of the forehead, draw a line horizontally with the eyebrows.

② At the beginning of the part, draw a vertical line from the line of ①.

③ Draw parallel vertical lines at regular intervals based on the line in ②.

④ Draw a horizontal line parallel to ① between ③ and ②, and then calculate the angle to the root of the hair.

(Unit: angle (°)) Just before using shampoo Immediately after using shampoo Manufacturing Example 1 19.531±4.331 20.141±2.538 Manufacturing Example 2 19.094±4.465 23.590±3.441 Comparative Production Example 1 19.309±4.441 20.038±2.389 Comparative Production Example 2 19.553±3.684 20.531±2.221 Comparative Production Example 3 19.312±4.101 20.389±2.163 Comparative Production Example 4 19.411±3.967 20.037±2.313 Comparative Production Example 5 19.238±3.898 20.142±3.034 Comparative Production Example 6 19.337±3.449 20.397±3.238 Comparative Production Example 7 19.307±4.030 20.187±2.520

From Table 6, FIGS. 4 and 5, the shampoo prepared with the composition according to Preparation Example 2 is more helpful in improving the root volume of newborn hair than the shampoo prepared with the composition according to Preparation Example 1 and Comparative Preparation Examples 1 to 7 You can check the zoom.

Although the preferred embodiments of the present invention have been described in detail above, the scope of the present invention is not limited thereto, and various modifications and improvements by those skilled in the art using the basic concept of the present invention defined in the following claims are also present. It belongs to the scope of the invention.

Claims (28)

A composition for preventing hair loss and promoting hair growth, comprising 5 kinds of peptides and polyols as active ingredients. In claim 1,
The composition of the five kinds of peptides contained in 0.0001% to 0.5% by weight based on the total amount of the composition. In claim 1,
The 5 kinds of peptides are
A first peptide consisting of a complex compound of three amino acids and metal ions,
A second peptide consisting of two amino acids,
A third peptide comprising an acetyl group at 4 ends and consisting of 4 amino acids,
A fourth peptide consisting of the three amino acids, and
The fifth peptide comprising a palmitoyl group at the terminal and consisting of 5 amino acids
Composition comprising a. In paragraph 3,
The first peptide is a composition containing the highest amount of the five kinds of peptides. In paragraph 3,
The first peptide is included in an amount higher than that of the second peptide,
The second peptide is included in an amount higher than that of the third peptide,
The second peptide is included in an amount higher than that of the fourth peptide,
The composition of the second peptide is contained in an amount higher than that of the fifth peptide. In clause 5,
The third peptide and the fourth peptide are contained in an amount higher than that of the fifth peptide. In paragraph 3,
The third peptide and the fourth peptide are included in the same amount as each other. In paragraph 3,
The first peptide is a composition containing 0.1% to 0.45% by weight based on the total amount of the composition. In paragraph 3,
The second peptide is a composition containing 0.005% by weight to 0.05% by weight based on the total amount of the composition. In paragraph 3,
The third peptide and the fourth peptide are each independently contained in an amount of 0.001% to 0.01% by weight based on the total amount of the composition. In paragraph 3,
The fifth peptide is a composition containing 0.00001% to 0.001% by weight based on the total amount of the composition. In paragraph 3,
The composition of the first peptide is copper tripeptide-1. In paragraph 3,
The composition of the second peptide is carnosine. In paragraph 3,
The third peptide is an acetyltetrapeptide-3 composition. In paragraph 3,
The composition of the fourth peptide is tripeptide-1. In paragraph 3,
The fifth peptide is a palmitoyl pentapeptide-4 composition. In claim 1,
The polyol is a composition comprising glycerin, hexanediol, or a combination thereof. In claim 1,
The polyol is a mixture of glycerin and 1,2-hexanediol in a weight ratio of 10:1. In claim 1,
The composition further comprises purified water. In paragraph 19,
The composition, based on the total amount of the composition
0.0001% to 0.5% by weight of the five kinds of peptides;
10% to 45% by weight of the polyol; And
The remaining amount of purified water
Composition comprising a. In claim 1,
The composition is a composition, characterized in that promoting the proliferation of dermal papilla cells or hair follicle cells in vitro. A scalp and hair cosmetic comprising the composition of any one of claims 1 to 21. In claim 22,
The scalp and hair cosmetics are scalp and hair cosmetics further comprising an oil, a surfactant, a viscosity modifier, a pH modifier, a fragrance, or a combination thereof. In clause 23,
The surfactant is an anionic surfactant, scalp and hair cosmetics. In clause 23,
The viscosity modifier is a cationic polymer scalp and hair cosmetic. In clause 23,
The pH adjusting agent isopropanolamine scalp and hair cosmetics. In claim 22,
The scalp and hair cosmetics are any one selected from the group consisting of shampoo, hair rinse, hair tonic, hair gel, hair lotion, hair pack, hair spray, hair mousse, hair treatment, soap, ampoule, and hair dye. In claim 22,
The scalp and hair cosmetic is a hair cosmetic that satisfies the following Equation 1.
[Equation 1]
(Water repellent after 6 weeks of using hair cosmetic / Water repellent after 3 weeks of using hair cosmetic) x 100 <80

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