KR20200083532A - 적어도 1종의 스플라이세오솜 조정제, 및 bcl2 억제제, bcl2/bclxl 억제제 및 bclxl 억제제로부터 선택된 적어도 1종의 억제제를 포함하는 조합물 및 사용 방법 - Google Patents

적어도 1종의 스플라이세오솜 조정제, 및 bcl2 억제제, bcl2/bclxl 억제제 및 bclxl 억제제로부터 선택된 적어도 1종의 억제제를 포함하는 조합물 및 사용 방법 Download PDF

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KR20200083532A
KR20200083532A KR1020207015324A KR20207015324A KR20200083532A KR 20200083532 A KR20200083532 A KR 20200083532A KR 1020207015324 A KR1020207015324 A KR 1020207015324A KR 20207015324 A KR20207015324 A KR 20207015324A KR 20200083532 A KR20200083532 A KR 20200083532A
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cancer
inhibitor
use according
spliceosome
pharmaceutically acceptable
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다니엘 에어드
로라 코르손
핑 주
마르쿠스 바르무트
실비아 부오나미치
피터 제라드 스미스
피터 페케스
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에자이 알앤드디 매니지먼트 가부시키가이샤
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/47—Quinolines; Isoquinolines
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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KR1020207015324A 2017-10-31 2018-10-30 적어도 1종의 스플라이세오솜 조정제, 및 bcl2 억제제, bcl2/bclxl 억제제 및 bclxl 억제제로부터 선택된 적어도 1종의 억제제를 포함하는 조합물 및 사용 방법 Pending KR20200083532A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762579666P 2017-10-31 2017-10-31
US62/579,666 2017-10-31
US201762580364P 2017-11-01 2017-11-01
US62/580,364 2017-11-01
PCT/US2018/058277 WO2019089641A1 (en) 2017-10-31 2018-10-30 Combination comprising at least one spliceosome modulator and at least one inhibitor chosen from bcl2 inhibitors, bcl2/bclxl inhibitors, and bclxl inhibitors and methods of use

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KR20200083532A true KR20200083532A (ko) 2020-07-08

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KR1020207015324A Pending KR20200083532A (ko) 2017-10-31 2018-10-30 적어도 1종의 스플라이세오솜 조정제, 및 bcl2 억제제, bcl2/bclxl 억제제 및 bclxl 억제제로부터 선택된 적어도 1종의 억제제를 포함하는 조합물 및 사용 방법

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US (1) US11524009B2 (https=)
EP (1) EP3703755B1 (https=)
JP (2) JP2021505526A (https=)
KR (1) KR20200083532A (https=)
CN (1) CN111727059A (https=)
AU (1) AU2018360559B2 (https=)
BR (1) BR112020008362A2 (https=)
CA (1) CA3079089A1 (https=)
IL (1) IL274150A (https=)
MX (1) MX2020004179A (https=)
SG (1) SG11202003197TA (https=)
WO (1) WO2019089641A1 (https=)

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US11203591B2 (en) 2018-10-31 2021-12-21 Gilead Sciences, Inc. Substituted 6-azabenzimidazole compounds
EP3972695A1 (en) 2019-05-23 2022-03-30 Gilead Sciences, Inc. Substituted exo-methylene-oxindoles which are hpk1/map4k1 inhibitors
EP4051286A1 (en) * 2019-10-29 2022-09-07 Institut National de la Santé et de la Recherche Médicale (INSERM) Methods and compositions for treating uveal melanoma
AU2021284401A1 (en) * 2020-06-05 2023-01-05 Eisai R&D Management Co., Ltd. Anti-BCMA antibody-drug conjugates and methods of use
ES2919898B8 (es) * 2021-01-27 2024-02-02 Fundacion Univ San Antonio Nuevo tratamiento del cáncer colorrectal
CN112691195B (zh) * 2021-02-02 2023-03-14 黑龙江省科学院高技术研究院 Prpf8表达抑制剂在制备治疗肺癌的药物中的应用

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JP4459051B2 (ja) 2002-07-31 2010-04-28 メルシャン株式会社 新規生理活性物質
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BR0316746A (pt) 2002-11-29 2005-10-18 Mercian Corp Método de produção do composto macrolida 11107d, linhagem streptomyces sp.ab-1704 (ferm bp-8551), linhagem mortierella sp. f1529 (ferm bp-8547) ou linhagem f-1530 (ferm bp-8548), e linhagem ab-1896 (ferm bp-8550)
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WO2019089641A1 (en) 2019-05-09
US20200352937A1 (en) 2020-11-12
IL274150A (en) 2020-06-30
US11524009B2 (en) 2022-12-13
EP3703755B1 (en) 2024-07-31
CN111727059A (zh) 2020-09-29
AU2018360559A1 (en) 2020-05-07
MX2020004179A (es) 2020-08-03
RU2020117201A (ru) 2021-12-01
JP2023109899A (ja) 2023-08-08
CA3079089A1 (en) 2019-05-09
RU2020117201A3 (https=) 2022-03-31
EP3703755A1 (en) 2020-09-09
JP2021505526A (ja) 2021-02-18
AU2018360559B2 (en) 2024-08-22
SG11202003197TA (en) 2020-05-28
BR112020008362A2 (pt) 2020-11-03

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