KR20200069711A - Scalp essences for scalp care - Google Patents

Abstract

The present invention relates to a scalp essence for scalp care that improves tensile strength of hair to prevent hair loss, prevents hair loss by reducing scalp keratin and oil, and improves hair growth capacity by increasing the number of hairs. The present invention relates to a scalp essence for scalp care including, as an active ingredient, a mixture containing predetermined parts by weight of sodium heparin water with respect to 100 parts by weight of a natural extract complex composition.

Description

Scalp essences for scalp care}

The present invention relates to a scalp essence for scalp care that improves the tensile strength of hair to prevent hair loss, prevents hair loss by improving scalp keratin and oil, and improves hair growth by increasing the number of hairs.

In modern society, the living body is gradually damaged due to a lot of stress, and hair loss is a major social issue. Hair loss is caused by various factors such as sluggish hair growth and lack of growth factors that promote hair cell growth.

Hair loss refers to a state in which hair is loose or lost, and the number of human hairs is about 150,000 to 150,000, and it has a unique cycle of anagen, catagen, and telogen, and repeats growth and elimination. And, on average, about 100 hairs per day are naturally hair loss. Although the mechanism of hair loss has not been clearly identified, studies have been conducted so far that excessive sebum production due to abnormal endocrine system such as hormonal imbalance, circulatory system disorders such as autonomic nervous system and blood circulation disorder, nutritional deficiency of hair roots, allergies, bacterial infection, and heredity The cause is presumed to be caused by aging factors, mental stress, environmental factors such as air pollution or food, and aging. Alopecia has occurred only in the middle-aged and older, but recently it has also occurred frequently in young people in their 20s and 30s.

The most common type of male alopecia is male pattern baldness or alopecia, which occurs gradually over the years, most pronounced at the crown of the head and proceeds to the frontal region. In the case of female hair loss, the thickness of the hair becomes thinner, resulting in a more dispersed form and often appears after menopause.

Such hair loss deteriorates the quality of life due to mental stress and causes a lot of problems in interpersonal relationships and social life. In social life, the image emanating from appearance approaches very impressively, and the interest in hair loss causes and treatment is increasing day by day because the importance of the appearance becomes self-esteem or an invisible vitality of social life.

Many studies have been conducted to alleviate or treat alopecia, and research has been conducted in the cosmetics or pharmaceutical industry for a long time to develop new substances for stimulating hair growth or alleviating hair loss, and accordingly female hormonal drugs, blood flow Drug therapies using accelerators and hair transplantation methods have been developed. Currently, the most widely used drug for the treatment of hair loss is 2,4-diamino-6-piperidinopyrimidine-3-oxide (aka'Minoxidil'), which has been approved by the FDA. 4,139,619 and 4,596,812) and finasteride, which are specific inhibitors of type II 5α reductase.

Minoxidil formulation was a drug developed as a therapeutic agent for hypertension in a way that increases blood flow through the vasodilating effect.However, as it was found that this effect has a great effect on inducing hair growth by supplying nutrients to the hair roots, it has recently been widely used as a treatment for androgenetic alopecia. It is used, and it is known to be particularly effective in alleviating the symptoms of hair loss in the kiln area, and pharmaceuticals using it as an active ingredient are marketed under the trade name Rogaine (trade name of Pharmacia & Upjohn Company).

Rogaine is known to reduce hair loss and promote hair growth in men with androgenetic alopecia, but should be applied directly from the outside to the scalp area, regularly used over a long period of time, and used for hair loss outside the kiln area. Regarding this, there is a disadvantage that it does not have a very good effect. On the other hand, minoxidil does not cause new hair to appear, but rather plays a role in preventing the existing thinned hair from becoming thick or falling out, and according to clinical studies, it is known that it is effective for less than 30% of alopecia patients.

In addition, the composition for the treatment of hair loss containing minoxidil has a strong odor, and its viscosity is high, so users may have difficulty using it at work or at work due to the discomfort of the odor, and the stickiness from the high viscosity Rather, it is often caused by skin irritation due to the unsanitary problem of the scalp due to the unpleasant sensation and hardening of the hair discharge.

Medicines using finasteride as an active ingredient are marketed under the trade name Propecia (trade name of Merck & Co, Inc.), which is a pill for oral administration that inhibits the function of type II 5α reductase, causing testosterone to dihydrotestosterone. DHT) is known to inhibit hair loss. However, this also requires constant and regular administration, and for some patients, there is a problem that it exhibits side effects such as decreased libido and impotence.

In addition, based on natural plant extracts, composition usage or hair transplantation methods are used as a method for preventing hair loss and promoting hair growth. However, natural plant extracts do not have a positive effect on hair growth because the condition of hair or alopecia varies among individuals, and there is difficulty in long-term continuous use due to skin irritation or unpleasant smell, and hair transplantation method There are problems such as tally phenomenon after transplantation, the need for additional transplant surgery, and high cost.

1. Republic of Korea Patent Publication No. 10-2018-0019047. 2. Korean Patent Publication No. 10-2015-0059709.

In the present invention, to improve the tensile strength of the hair to prevent hair loss, and to provide a liquid scalp essence for scalp care to improve scalp keratin and oil, scalp care, hair protection and strength improvement and hair loss prevention and hair growth improvement The solution is to provide a scalp essence for scalp care that contains a complex composition of natural extracts and sodium heparin water, which are effective for the treatment.

However, the problem to be solved in the present invention is not limited to the above-mentioned problems, and other problems not mentioned can be clearly understood by those skilled in the art from the following description of the detailed description of the invention.

The scalp essence for scalp care of the present invention, which solves the above problems, is characterized in that it comprises a mixture containing parts by weight of sodium heparin water (Sodium Heparin Water) with respect to 100 parts by weight of the natural composition.

Here, the complex composition of the natural extract is a cornus extract; Goji berry extract; Mountain mulberry leaf extract; Rice bran extract; Omija extract; Jujube extract; Persimmon extract; Ginkgo leaf extract; Lobule extract; Tangerine peel extract; Deodeok extract; Big gourd root extract; Road extract; Sewage extract; Donggulle extract; Bean sprout extract; Spiny root extract; Licorice extract; Cheongho extract; Eoseongcho extract; Characterized in that it is a mixture of any one of thistle flower extract, thistle leaf extract or thistle stem extract, hostile kelp extract, pogongyoung extract,

The mixture is a portion of the arithmetic oil extract; Goji berry extract parts by weight; Mountain mulberry leaf extract parts by weight; Parts by weight of rice bran extract; Omija extract parts by weight; Jujube extract parts by weight; Persimmon extract parts by weight; Ginkgo leaf extract parts by weight; Cotyledon extract weight part; Tangerine peel extract parts by weight; Deodeok extract parts by weight; Parts of the big gourd root extract; Long diameter extract parts by weight; Sewage extract parts by weight; Donggulle extract parts by weight; Bean sprout extract parts by weight; Prickly root extract parts by weight; Licorice extract parts by weight; Cheongho extract parts by weight; Eoseongcho extract weight parts; Characterized in that it is made by mixing the weight part of thistle flower extract, the weight part of any one of thistle leaf extract or thistle stem extract, the weight part of the host tail kelp extract, and the weight part of the porosity extract.

Here, the sodium heparin water is characterized in that a mixture of sodium heparin, green tea extract, persimmon leaf extract, ginseng extract, black bean extract, western dandelion extract and purified water,

The sodium heparin water is characterized by being mixed to include sodium heparin weight%, green tea extract weight%, persimmon leaf extract weight%, ginseng extract weight%, black soybean extract weight%, western dandelion extract weight% and the balance of purified water. do.

Here, the mixture is mixed to include a weight part, a thickener weight part, a pH adjuster weight part, a preservative part weight part, a solubilizer part weight part, a moisturizer part weight part, a fragrance additive part part and purified water part part It is characterized by.

The scalp essence for scalp care provided by the present invention has the effect of preventing hair loss, protecting hair, and improving the strength and hair growth of hair by improving scalp keratin, improving scalp oil, and improving the tensile strength of hair. .

1 shows a selected test site of a scalp area including the hair of a test subject according to an embodiment of the present invention.
2 to 7 is a graph showing the evaluation results of the scalp improvement of the test subject according to an embodiment of the present invention.
Figure 8 shows a BASP (Basic and specific) classification for visual evaluation of hairline changes according to an embodiment of the present invention.
9 is a graph showing the results of measuring the change in the number of hair according to an embodiment of the present invention.

Hereinafter, the present invention will be described in more detail.

The present inventors of the present invention improve the tensile strength of the hair to prevent hair loss, improve the scalp keratin and oil, prevent hair loss, and provide the scalp essence for scalp care that improves hair growth by increasing the number of hairs. It was completed.

The scalp essence for scalp care achieving the object of the present invention is characterized in that it contains a mixture containing parts by weight of sodium heparin water (Sodium Heparin Water) as an active ingredient, based on 100 parts by weight of the natural composition.

According to the present invention, the natural product extract complex composition is a cornus extract; Goji berry extract; Mountain mulberry leaf extract; Rice bran extract; Omija extract; Jujube extract; Persimmon extract; Ginkgo leaf extract; Lobule extract; Tangerine peel extract; Deodeok extract; Big gourd root extract; Road extract; Sewage extract; Donggulle extract; Bean sprout extract; Spiny root extract; Licorice extract; Cheongho extract; Eoseongcho extract; Use a mixture of thistle flower extract, thistle leaf extract, or thistle stem extract, a mixture of horsetail kelp extract and pogongyoung extract,

Preferably, the mixture comprises parts by weight of cornus officinalis extract; Goji berry extract parts by weight; Mountain mulberry leaf extract parts by weight; Parts by weight of rice bran extract; Omija extract parts by weight; Jujube extract parts by weight; Persimmon extract parts by weight; Ginkgo leaf extract parts by weight; Cotyledon extract weight part; Tangerine peel extract parts by weight; Deodeok extract parts by weight; Parts of the big gourd root extract; Long diameter extract parts by weight; Sewage extract parts by weight; Donggulle extract parts by weight; Bean sprout extract parts by weight; Prickly root extract parts by weight; Licorice extract parts by weight; Cheongho extract parts by weight; Eoseongcho extract weight parts; It is preferable to use a composite composition comprising a mixture of thistle flower extract part by weight, thistle leaf extract or thistle stem extract part by weight, host tail kelp extract part by weight, and porosity extract part by weight.

According to the present invention, the sodium heparin water is a mixture of sodium heparin, green tea extract, persimmon leaf extract, ginseng extract, black bean extract, western dandelion extract and purified water,

Preferably, the sodium heparin water is mixed to include sodium heparin weight%, green tea extract weight%, persimmon leaf extract weight%, ginseng extract weight%, black soybean extract weight%, western folk extract weight% and the balance of purified water. It is good to use.

At this time, the sodium heparin is a key material for improving the scalp, there may be a problem when the amount mixed with the sodium heparin water is less than weight%, and if it exceeds the weight%, there may be a problem.

According to the present invention, the disclosed scalp essence contains a mixture containing the natural extract extract composition and sodium heparin water as an active ingredient, such as a thickener, pH adjusting agent, preservative, solubilizer, moisturizer, etc. By mixing additives used in cosmetics in a certain weight ratio, it can be manufactured as a liquid or soft lotion type product.

At this time, preferably, 100 parts by weight of the natural extract complex composition, parts by weight of a mixture containing sodium heparin water (Sodium Heparin Water) parts by weight, weight parts by weight, pH control agent parts by weight, preservative parts by weight, solubilizer It may be mixed to include parts by weight, parts by weight of a moisturizer, parts by weight of a fragrance additive, and parts by weight of purified water.

The composition ratio of each of the above components is, for example, it can be easily understood by those skilled in the art that it is possible to manufacture and process the scalp essence by further adding other useful ingredients, such as vitamins, which have a beneficial effect on the scalp or hair during final production. It will be a part.

Various experiments have been conducted in order to verify the effectiveness of the scalp essence for scalp care provided by the present invention described above, and the experimental examples are as described below. However, the experimental examples described below are for explaining and understanding the present invention, and the present invention is not limited to the following experimental examples, and a person skilled in the art can deform any number within the scope described in the claims. .

[Experimental Example 1]

The sodium heparin water constituting the present invention was prepared, and the effect on improving scalp keratin, scalp oil and hair tensile strength was examined.

1. Experimental material: sodium heparin water preparation

Sodium heparin water was prepared by mixing sodium heparin weight%, green tea extract weight%, persimmon leaf extract weight%, ginseng extract weight%, black soybean extract weight%, western dandelion extract weight%, and the balance of purified water.

2. Experiment

2-1. Experiment period: 14 days

2-2. Subject: 23 adult women over 20 years of age who meet the criteria for selection and do not meet the exclusion criteria

2-3. Experiment method:

1) How to use the sample: twice a day for 14 days during the test period, spray the same amount of sodium heparin water evenly on the hair and scalp of the test site as shown in Fig. 1, and then absorb.

2) Evaluation method:

end. Instrument Measurement:

-Keratin sticker and image analysis program improve scalp keratin

evaluation

-Evaluation of oil scalp improvement using Sebumeter

-Evaluation of improvement of tensile strength of hair by tensile strength tester

I. Skin adverse reaction evaluation

All. Survey

2-4. Experiment result

1) Evaluation result of scalp keratin improvement by Keratin sticker and image analysis program

-As a result of evaluating whether or not the scalp keratin was improved before and after using the test substance, as shown in FIGS. 2 and 3, the scalp keratinity was reduced by 60.54% after 2 weeks of use compared to the test substance before, indicating that the scalp keratin was improved. (P<.001)

2) Evaluation result of scalp oil improvement using Sebumeter

-As a result of evaluation of scalp oil improvement before and after the use of the test substance, as shown in FIGS. 4 and 5, the amount of sebum was reduced by 46.66% after 14 days of use compared to the test substance use, indicating that the scalp oil was improved.(p< .001)

3) Evaluation result of hair tensile strength improvement using tensile strength tester

-As a result of evaluation of the improvement of the tensile strength of the hair before and after the use of the test substance, as shown in FIGS. 6 and 7, the hair tensile strength was increased by 11.59% after 2 weeks of use compared to the test substance use ws, indicating that the hair tensile strength was improved.( p<.05)

4) Skin adverse reaction evaluation results

-Evaluation of skin adverse reactions by the person in charge of the experiment: No adverse reactions to allergic contact dermatitis or irritant contact dermatitis were observed after using the test substance in the test subject.

-Skin adverse reactions due to the subject's questionnaire: Apart from the evaluation of adverse reactions by the test subject, the skin reactions reported by the subject as a result of the questionnaire are shown in Table 1 below. As can be seen from Table 1 below, no special skin adverse reaction was observed. Table 1 shows the skin reactions reported by the subjects.

Adverse reactions 2 weeks after use Adverse reactions 2 weeks after use 1.Erythema (redness) 0 5. Ache (pain) 0 2. Edema (swelling) 0 6. Burning sensation 0 3. Insul (Keratin) 0 7. Stiffness 0 4. Itching 0 8. tingling 0

0: None, 1: Weak, 2: Medium, 3: Severe

As a result of looking at the results of Table 1, no adverse skin reactions were observed from the subjects during the experiment.

As a result of the above experiment, it is judged that the sodium heparin water constituting the present invention helps to improve scalp keratin, scalp oil, and hair tensile strength.

[Experimental Example 2]

1. Experimental substance

1-1. Natural extract extract composition: parts by weight of Cornus officinalis extract; Goji berry extract parts by weight; Mountain mulberry leaf extract parts by weight; Parts by weight of rice bran extract; Omija extract parts by weight; Jujube extract parts by weight; Persimmon extract parts by weight; Ginkgo leaf extract parts by weight; Cotyledon extract weight part; Tangerine peel extract parts by weight; Deodeok extract parts by weight; Parts of the big gourd root extract; Long diameter extract parts by weight; Sewage extract parts by weight; Donggulle extract parts by weight; Bean sprout extract parts by weight; Prickly root extract parts by weight; Licorice extract parts by weight; Cheongho extract parts by weight; Eoseongcho extract weight parts; Prepare a complex composition by mixing to include the weight part of thistle flower extract, the weight part of thistle leaf extract or the thistle stem extract, the weight part of the host tail kelp extract, and the weight part of the porosity extract.

1-2. The sodium heparin water prepared in Experimental Example 1 was used.

1-3. Other substances: (thickener), (pH regulator), (preservative), (solubilizer), (moisturizer), (flavor additive) are prepared.

1-4. Scalp Essence Preparation: Prepare a mixture of the composite composition and sodium heparin water in a weight ratio of 100 parts by weight of sodium heparin water parts by weight,

The scalp essence is prepared by processing the mixture to include parts by weight, parts by weight of a thickener, parts by weight of a pH adjusting agent, parts by weight of a preservative, parts by weight of a solubilizer, parts by weight of a moisturizer, parts by weight of a fragrance additive, and parts by weight of purified water Ready.

2. Experiment

2-1. Experiment period: 12 weeks

2-2. Experimental standard:

1) Guidelines for human application and efficacy test of cosmetics in the Ministry of Food and Drug Safety 9 Guide -0333-01)

2) Guidelines for human application test of cosmetics to help relieve symptoms of hair loss at the Food and Drug Administration (Guideline 0760-01)

3) Provision of own test method

2-3. Experiment site: scalp, hair

2-4. Subject: 13 adults who are 40 years of age or older who meet the criteria for selecting subjects and do not meet the exclusion criteria

2-5. Experiment method:

1) Use of test substance: 12 to 12 times per test period, 2 to 3 times/day for scalp and hair (0, 6, 12 weeks measurement)

2) Evaluation: Hair count measurement (Folliscope2.8, LeadM Co.), Global evaluation of hairline change (Global Hair Divice, Canfield Scientific, Inc.) (BASP classification in FIG. 8, visual evaluation of relief of alopecia symptoms), subjective subject Survey evaluation

3) Before and after product use (0 weeks), after product use, at 6 and 12 weeks of measurement, comparative evaluation was conducted before and after product use.

2-6. Results of experiment effectiveness

1) As a result of analyzing the number of hairs (number/cm 2 ), as shown in FIG. 9, it was statistically significantly increased at 6 weeks and 12 weeks after product use compared to before (0 week) product use. (6 weeks: p <0.01, 12 weeks; p <0.001)

2) As a result of visual evaluation according to the BASP classification after photographing the change in hairline, there was no significant difference in the 6th and 12th weeks after using the product compared to before (0 weeks). As a result of visually evaluating the relief of hair loss symptoms on a 7-point scale, there was no significant difference in the 6th and 12th weeks after the product was used compared to before (0 weeks).

3) As a result of the subject's questionnaire evaluation, it showed a high positive response rate in parietal hair improvement and overall hair improvement items at week 12 after product use compared to before product use (0 week).

As described above, the scalp essence provided according to the present invention not only improves the scalp keratin, improves scalp oil, and improves the tensile strength of the hair, but also prevents hair loss, protects the hair, improves the strength of the hair, and improves hair growth It was found to have the effect of improving the. In particular, it was found that it does not show any special skin adverse reactions on the scalp, and thus can provide a product with excellent stability.

Claims (6)

A scalp essence for scalp care that contains a mixture containing parts by weight of sodium heparin water as an active ingredient, with respect to 100 parts by weight of a natural extract complex composition. According to claim 1,
The natural product extract composite composition is a Cornus officinalis extract; Goji berry extract; Mountain mulberry leaf extract; Rice bran extract; Omija extract; Jujube extract; Persimmon extract; Ginkgo leaf extract; Lobule extract; Tangerine peel extract; Deodeok extract; Big gourd root extract; Road extract; Sewage extract; Donggulle extract; Bean sprout extract; Spiny root extract; Licorice extract; Cheongho extract; Eoseongcho extract; A scalp essence for scalp care, characterized in that it is a composite composition of thistle flower extract, thistle leaf extract, or any one of thistle stem extract, horsetail kelp extract, and pogongyoung extract. According to claim 2,
The composite composition is a portion of the Cornus officinalis extract; Goji berry extract parts by weight; Mountain mulberry leaf extract parts by weight; Parts by weight of rice bran extract; Omija extract parts by weight; Jujube extract parts by weight; Persimmon extract parts by weight; Ginkgo leaf extract parts by weight; Cotyledon extract weight part; Tangerine peel extract parts by weight; Deodeok extract parts by weight; Parts of the big gourd root extract; Long diameter extract parts by weight; Sewage extract parts by weight; Donggulle extract parts by weight; Bean sprout extract parts by weight; Prickly root extract parts by weight; Licorice extract parts by weight; Cheongho extract parts by weight; Eoseongcho extract weight parts; A scalp essence for scalp care, characterized in that it is made by mixing the weight part of thistle flower extract, the weight part of thistle leaf extract or the thistle stem extract, the weight part of the host stem kelp extract, and the weight part of the porosity extract. According to claim 1,
The sodium heparin water is a scalp essence for scalp care, characterized by mixing sodium heparin, green tea extract, persimmon leaf extract, ginseng extract, black bean extract, western dandelion extract and purified water. The method of claim 4,
The sodium heparin water is characterized by being mixed to include sodium heparin weight%, green tea extract weight%, persimmon leaf extract weight%, ginseng extract weight%, black soybean extract weight%, western dandelion extract weight% and the balance of purified water. Scalp essence for scalp care. According to claim 1,
For the scalp care that is mixed to include the mixture parts by weight, thickener parts by weight, pH adjusting agent parts by weight, preservative parts by weight, solubilizer parts by weight, moisturizer parts by weight, flavor additives parts by weight and purified water parts by weight Scalp essence.

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