KR20200061680A - Cosmetic composition containing natural substances for prevention and treatment of pimples - Google Patents

Abstract

The present invention relates to a cosmetic composition comprising a natural substance effective in pimples. Various medicinal stuffs have been developed and used in a treatment area of pimples, but have showed an insignificant healing effect and a frequent recurrence without any preventive concept. In addition, a cosmetic composition for taking care of acne-prone skin has not been studied yet in reality without any product with a healing concept. Accordingly, the present invention is to develop a cosmetic composition capable of preventing and healing pimples and to provide a cosmetic composition effective in preventing and healing pimples by applying natural substances such as Angelica dahurica root, Coptis chinensis, Scutellaria baicalensis, Licorice root or Arctium lappa.

Description

Cosmetics containing natural products that have an acne treatment effect{COSMETIC COMPOSITION CONTAINING NATURAL SUBSTANCES FOR PREVENTION AND TREATMENT OF PIMPLES}

The present invention relates to cosmetic products containing natural products that are effective for acne. More specifically, the present invention relates to cosmetics effective in the treatment and prevention of acne by containing at least one natural product selected from white paper, yellow lotus, licorice, golden and burdock.

Acne refers to chronic, refractory, and inflammatory skin diseases occurring in the hair follicles and sebaceous glands, and the causes of such acne are largely increased sebum secretion, narrowing of the hair follicles due to hyperkeratosis, and proliferation of acne bacteria. , It can be explained according to the degree of development of acne symptoms due to an inflammatory reaction, etc., and various mechanisms may work in combination.

In other words, estrogen, which is an increased sex hormone after puberty, can excessively increase the secretion of sebum and cause narrowing of hair follicles. In addition, since the lipid composition of sebum is different from the skin epidermis, it is well oxidized and used as an energy source for acne bacteria.

In addition, acne bacteria are anaerobic bacteria and do not multiply when the hair follicle is open. That is, as sebum increases and hyperkeratization of the hair follicle progresses, the entrance to the hair follicle becomes clogged, resulting in the occurrence of acne, which is an initial lesion of acne, and excessive proliferation of acne bacteria.

Increased acne bacteria metabolize the lipids of sebum to produce several fatty acids that become irritants, and acne bacteria are recognized as antigens, stimulating the immune response in the body, resulting in an inflammatory reaction. This causes papules and inflammatory acne lesions, and when deteriorated, follicle walls are destroyed and tissues develop into lesions such as cysts and pustules.

Various medicines have been developed and used in the area of acne treatment, but the selection of cosmetics for proper skin care has not been studied.

In the cosmetics area, it is mainly a soap, a medicinal soap, an abrasive cleanser, and the like. It is a concept that heals acne by removing hair follicle stenosis mainly through skin peeling. In addition, the peeling of the skin and the antiseptic effect of acne bacteria by the alcohol component of the astrigent also have a certain effect on acne. There are also cosmetics containing resorcinol, sulfur, salicylic acid, and benzoyl peroxide. However, these raw materials have skin irritation and thus have many side effects and limitations, such as restrictions on the concentration of use.

In addition, antibiotics such as erythromycine for the removal of acne bacteria, anti-inflamation raw materials for the treatment of inflammation, and hormone preparations for sebum control are used, but these are mainly raw materials for the pharmaceutical field.

The product so far has been developed with a focus on only one of the various mechanisms of acne described above, and its healing effect is minimal and recurrence is frequent, and there is no preventive concept. Also, there are no products with healing concepts in the cosmetics area.

Therefore, the inventors of the present inventors repeatedly studied politely in order to develop a cosmetic product that can be cured as well as preventing acne. The invention was completed.

That is, the object of the present invention is to provide a cosmetic that is effective in the prevention and treatment of acne containing white paper, yellow lotus, golden, licorice or burdock.

Cosmetics effective for acne according to the present invention for achieving the above object is characterized in that it contains at least one selected from the group consisting of white paper, hwangnyeon, golden, burdock and licorice among natural products.

The cosmetic product according to the present invention is prescribed so as not to cause irritation of skin or irritation by removing all lipids similar to the lipid component of sebum. In addition, in order to suppress excessive sebum, natural substances such as yellow sesame oil, burdock, golden extract, licorice with excellent antibacterial activity against acne bacteria, and white paper, which is an anti-inflammatory substance, can be mixed to respond to all mechanisms that cause acne. Consists of raw material composition.

As described above, it can be seen that the cosmetic product according to the present invention is effective in the treatment and prevention of acne by containing white paper, golden, yellow lotus, licorice or burdock.

Natural products used in the cosmetic for acne according to the present invention are as follows.

1) white paper

Scientific name: Angelica daurica

Plants: This is a perennial grass with a height of 1 to 15m. In summer, small white flowers gather at the ends of branches.

Fruits are small oval, and white paper is the name for the root. The roots are used in the fall by peeling the skin of the young plants that did not come out of the stalk and drying them in the sun.

Ingredients: The root (blank paper) contains about 03-09% of coumarin ingredients such as imperatorine, peloperin, and xanthroxine, and the essential oil content of more than 02%. In addition, it contains ingredients such as pelladrene, hydrocarotene, and oxypentadecilic acid.

Action: White paper has analgesic soothing effect. This is known to be due to the furokumarin component. In addition, the animal decoction was found to have anti-cancer activity in animal studies.

Application: Used in the treatment of sedatives, sedative medicine, pain medicine, blood medicine, cold, head pain, etc. It is also used for postpartum pain relief and is also used for rheumatoid and spinal nerve myositis.

2) Burdock

Scientific name: Arctium Lappa

Plant: This is a perennial plant with a height of 1 to 2m. The broad or long egg-shaped leaves are misaligned, and purple-red flowers gather at the ends of branches to bloom in the summer like round ears. Fruits are picked in the fall, dried in the sun, and shaken to collect. Roots are harvested in the fall, washed in water and dried before use.

Ingredients: Fruits are lignan glycosides, arcutin, oil 25-30%, phytosterin, vitamin B1, saponin, coumarin, lemon acid, malic acid, etc., roots are inulin 27-45%, protein 12%, essential oil 017%, It contains arctein, caffeic acid, tannins, and alkaloids.

Action: Fruits have diuretic, anti-inflammatory, and draining effects. In addition, the water extract of the fruit has an antibacterial action against filamentous fungi that cause skin diseases. Root has a diuretic action and a metabolism promoting action. In addition, the alkaloid component has anticancer activity.

Application: In the treatment of copper, the fruit is used for inflammatory drugs, fever-reducing drugs, colds, sore wounds, skin diseases, and malignant tumors.

Also, the root is used for gastritis, gastroduodenal ulcer, etc.

3) Hwangnyeon

Scientific name: Coptidis Rhizoma

Plant: Rootstock with almost no roots of Coptis japonica, containing more than 35% of berberine when quantifying dryness. Uneven cone, 2-4 cm, outer surface grayish brown, with stem and many roots underneath.

Ingredients: Berberine is the main ingredient and other palmatine is included. In addition, it contains about 3-7% of trace alkaloids.

Action: Water extract has anti-lipase action and anti-pepsine action, while methanol extract has anti-inflammatory action and prevents arteriosclerosis. In addition, 50% ethanol extract shows antibacterial activity against Staphylococcus aureus, antagonistic bacteria, and cholera bacteria, and 35% ethanol extract has a antispasmodic effect on the small intestine of the stomach.

Application: It is used as a raw material for gastrointestinal medicines and antidiarrheal drugs in oriental medicine

4) Licorice

Scientific name: Glycyrrhiza glabra

Plant: The main stem has a peculiar odor, a bud, a leaf, a peculiar smell, and a sweet taste. Use both peeled and peeled.

Ingredients: Triterpene glycoside, glabric acid, flavonones, isoflavones, etc. are contained.

Action: The main component of glycyrrhizin or genin activates estrogen action and has anti-inflammatory action, detoxification action, and anti-allergic action. In addition, the fraction containing a large amount of flavonoids has anti-ulcer and antispasmodic effects.

Application: In oriental medicine, it is widely used for cramps, muscle pains, etc., aiming at analgesic, detoxification, etc.

5) Golden

Scientific name: Scutellaria baicalensis

Plant: It means the root that peeled off the skin of the rotten grass. The rotten grass is yellowish brown with vertical wrinkles, and the quality is firm, but it has a soft, weak smell and bitter taste.

Ingredients: Flavonoids, baicalin, chrysin and other free amino acids are the main ingredients.

Action: It is prescribed for diseases involving anti-inflammatory, antipyretic, and abdominal pain.

The following tests were conducted to find out the efficacy of the above natural products for acne.

[Test Example 1: The effect of inhibiting the chemotaxis of acne bacteria by natural product samples]

1 Experiment method

end. Isolation of neutrophils leukocytes:

After separating the white blood cell layer and the red blood cell layer by Ficoll-paque methods, polymorphic nuclear leukocytes were separated with a 3% Dextran solution.

I. Chemical chemotaxis test and its inhibitory effect

1) Experiment Principle: Neutrophil leukocytes are moved by acne (P acnes) to cause inflammatory action. At this time, the movement of white blood cells is made by chemotaxis. When natural products, erythromycin and tretinoin are applied to acne bacteria, it suppresses chemotaxis and shows anti-inflammatory action.

2) Experimental method: A chemical experiment induced by a 1% P acnes solution was conducted using a natural product and a positive control material, erythromycin.

3) Evaluation method: Using the 48-well micro chemotaxis method, the number of neutrophil leukocytes migrated by the chemical chemotaxis of acne bacteria was observed in the field of view of 400 times under an optical microscope to determine whether or not to induce and inhibit the chemotaxis. Compare and judge.

2 Experiment result

Table 1 shows the results of testing the chemotaxis and its inhibitory effect caused by 1% acne solution.

As shown in Table 1, it can be seen that applying baekji, licorice, hwangnyeon, and burdock has a relatively small number of neutrophil leukocytes migrated, and thus has an effect of suppressing acne bacteria.

[Test Example 2: Confirmation of antibacterial activity against acne (P acnes)]

The antibacterial activity test for acne (P acnes) was carried out by the liquid medium dilution method.

After diluting each sample from 0 to 1000 ppm in 100 ml intervals in 2 ml of liquid BHI medium, 20 μl of 106/ml of the fungus was inoculated and cultured for 48 hours. The minimum concentration at which growth was inhibited based on turbidity was defined as the minimum growth inhibition concentration (MIC).

P acnes ATCC 6919 and ATCC 11827 were used as strains. Table 2 shows the results.

As shown in Table 2, it can be seen that gold, yellow lotus, and licorice are particularly excellent in antibacterial activity against acne bacteria.

[Test Example 3 Lipogenesis inhibition test]

As a method of evaluating the degree of lipid synthesis inhibition by quantifying the degree of uptake of carbon elements necessary for lipid synthesis, to evaluate the degree of lipid synthesis inhibition in the sebaceous gland, biopsy the hamster ear tissue with many sebaceous glands to label C14 The culture medium was cultured for 6 hours, and the degree of inhibition was evaluated by comparing and quantifying the control group and the sample group using a radioactivity meter. As the sample group, 001% of the sample solution was used for the right ear tissue of the hamster, and 001% of physiological saline was used for the medium of the left ear of the hamster as a control group. Table 3 shows the results. In Table 3, the inhibition rate was calculated by Equation 1 below, and the value is an average value of 4 hamsters.

As shown in Table 3, it can be seen that hwangnyeon, white paper, burdock, and licorice have an inhibitory effect on lipid synthesis. In other words, by suppressing lipid synthesis, sebum can be reduced to suppress acne.

[Test Example 4: primary stimulation test of human skin]

From the results of Test Examples 1-3, it can be seen that white paper, hwangnyeon, golden, burdock, and licorice have an acne treatment and prevention effect, and to find out whether the natural products are harmful to the human body when applied to cosmetics. Human skin stimulation test was performed.

The primary stimulation test for human skin was the human patch test. That is, it was conducted according to the CTFA guidelines (The Cosmetic, Toiletry and Fragrance Association Inc Washington, DC, 20036, 1991) for 30 healthy women aged 20-30. 20 μl of the test substance (10% in patch base) prepared in a pin chamber was added dropwise, washed with 70% ethanol, dried, and placed on the back of the test site and fixed with micropore tape. . The patch is applied for 24 hours, and after removing the patch, the test site is marked with a marking pen, and after 30 minutes and 24 hours, the skin reaction of each test site is observed, and the International Contact Dermatitis Research Group ; ICDRG). Table 4 shows the results.

In Table 4, the average reactivity was calculated according to the following Equation 2, ± 1 point, + 2 points, ++ 3 points, +++ 4 points. Judgment criteria were based on grade I (less stimulation range) less than 1, grade II (light stimulation range) less than 3, grade III (middle stimulation range) less than 5, and grade IV (strong stimulation range) 5 or higher. .

As shown in Table 4, the acne base showed a stimulus value in a safe range, but the stimulus was rather high. All raw materials showed a grade II or higher stimulus in the test prescription. However, Hwangnyeon showed the same stimulation and relatively high stimulation despite experiments at low concentrations due to the pigmentation problem. In the case of prescriptions combining various raw materials, they were all in the level of safety level II (less than 3 stimulus values).

[Example 1-25]

After preparing cosmetics containing natural substances with the composition of Tables 5 and 6, the sebum amount was changed, the effectiveness was evaluated, and the side effects were evaluated for each of the manufactured cosmetics, and the results are shown in Table 7.

Estimation of sebum change: Sebum was used to compare the results of sample treatment before and one month after treatment to evaluate sebum change through a reduced ratio.

Effectiveness evaluation: The effectiveness of the sample was evaluated by counting the number of pimples in a certain area and area of the subject's face before the sample treatment, and counting the number of pimples again a month after the treatment. For example, 50% effectiveness means that 50% of the total subjects have reduced acne counts by 20% or more.

Side effect evaluation: The presence or absence of side effects, such as irritation through the questionnaire of the subject, and the evaluation of the skin condition of the subject by two dermatologists, the evaluator, were evaluated to determine the presence or absence of side effects.

The'○' mark in Table 6 below indicates that the natural product marked'○' was additionally used in the composition of Table 5. In addition, the content of natural products used in each example is 02% white paper, 003% hwangnyeon, 02% licorice, 02% golden, and 02% burdock.

Claims (1)

Cosmetics characterized by containing at least one natural product selected from the group consisting of yellow lotus, burdock, golden, licorice and white paper.